10694-1-AP

antibody from Proteintech Group

Targeting: PLIN3 M6PRBP1, PP17, TIP47

Provider product page for 10694-1-AP

Western blot

ELISA

Immunocytochemistry

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Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [51]
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Validations
Western blot [1]
Immunoprecipitation [1]

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Product number: 10694-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10694-1-AP, RRID:AB_2297252
Product name: TIP47 antibody
Antibody type: Polyclonal
Description: TIP47 antibody (Cat. #10694-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PLIN3 protein structure - 10694-1-AP shown in red.

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Unraveling the potential mechanisms of Xiaochaihu decoction alleviates metabolic associated fatty liver disease (MAFLD) by integrated transcriptomics, metabolomics, and network pharmacology.

Zhong Y, Zhu XM, Li JC, Sheng LS, Qi JY, Shen XH, Du H, Huang NN, Sun R
Chinese medicine 2026 Jan 20;21(1):41

PLIN3-triggered lipophagic flux releases FFAs to facilitate CSFV propagation.

Li B, Zou L, Sun C, Jiang J, Li S, Wang J, He Y, Qin Y, Zeng S, Song Y, Zeng W, Yi L, Fan S, Chen J, Wu K
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STBD1 mediates the crosstalk between glycogen and lipid droplets in clear cell renal cell carcinoma.

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Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex.

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NR4A1-mediated regulation of lipid droplets in progesterone synthesis in goat luteal cells†.

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Alarmin-loaded extracellular lipid droplets induce airway neutrophil infiltration during type 2 inflammation.

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The Role of Neutral Sphingomyelinase-2 (NSM2) in the Control of Neutral Lipid Storage in T Cells.

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Rab2A-mediated Golgi-lipid droplet interactions support very-low-density lipoprotein secretion in hepatocytes.

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Apigenin Reduces Lipid Droplet Accumulation in Hepatocytes by Enhancing Chaperone-Mediated Autophagy via AMPK.

Lu J, Zhou H, Hu J, Zhang R, Meng Z, Guan S
Journal of agricultural and food chemistry 2024 Dec 18;72(50):27965-27977

Tumor-derived Prevotella intermedia aggravates gastric cancer by enhancing Perilipin 3 expression.

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Molecular cell 2024 Apr 18;84(8):1556-1569.e10

Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regulation.

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Developmental cell 2023 Sep 25;58(18):1782-1800.e10

The endo-lysosomal regulatory protein BLOC1S1 modulates hepatic lysosomal content and lysosomal lipolysis.

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Biochemical and biophysical research communications 2023 Jan 29;642:1-10

PNPLA2 mobilizes retinyl esters from retinosomes and promotes the generation of 11-cis-retinal in the visual cycle.

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Cell reports 2023 Feb 28;42(2):112091

Perilipin 2 Protects against Lipotoxicity-Induced Islet Fibrosis by Inducing Islet Stellate Cell Activation Phenotype Changes.

Zhou Y, Wang Y, Ni C, Wang H, Zhou J, Wan B, Li H, Li F, Huang R, Xu W, Shan T, Cai T, Kong X, Liu B, Liu X, Sun Z, Ma J
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Retrograde transport of CDMPR depends on several machineries as analyzed by sulfatable nanobodies.

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Knockdown of hepatocyte Perilipin-3 mitigates hepatic steatosis and steatohepatitis caused by hepatocyte CGI-58 deletion in mice.

Bao X, Ma X, Huang R, Chen J, Xin H, Zhou M, Li L, Tong S, Zhang Q, Shui G, Deng F, Yu L, Li MD, Zhang Z
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ACSS3 represses prostate cancer progression through downregulating lipid droplet-associated protein PLIN3.

Zhou L, Song Z, Hu J, Liu L, Hou Y, Zhang X, Yang X, Chen K
Theranostics 2021;11(2):841-860

Deficiency of intestinal Bmal1 prevents obesity induced by high-fat feeding.

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The autophagy protein ATG9A enables lipid mobilization from lipid droplets.

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Aryl hydrocarbon receptor promotes lipid droplet biogenesis and metabolic shift in respiratory Club cells.

Wang HC, Liu KY, Wang LT, Hsu SH, Wang SC, Huang SK
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Simultaneously targeting SOAT1 and CPT1A ameliorates hepatocellular carcinoma by disrupting lipid homeostasis.

Ren M, Xu H, Xia H, Tang Q, Bi F
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Integrated Action of Autophagy and Adipose Tissue Triglyceride Lipase Ameliorates Diet-Induced Hepatic Steatosis in Liver-Specific PLIN2 Knockout Mice.

Griffin JD, Bejarano E, Wang XD, Greenberg AS
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Feedback activation of GATA1/miR-885-5p/PLIN3 pathway decreases sunitinib sensitivity in clear cell renal cell carcinoma.

Yao D, Xia S, Jin C, Zhao W, Lan W, Liu Z, Xiu Y
Cell cycle (Georgetown, Tex.) 2020 Sep;19(17):2195-2206

KRAS Controls Pancreatic Cancer Cell Lipid Metabolism and Invasive Potential through the Lipase HSL.

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HILPDA Uncouples Lipid Droplet Accumulation in Adipose Tissue Macrophages from Inflammation and Metabolic Dysregulation.

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Multiplex fatty acid imaging inside cells by Raman microscopy.

Uematsu M, Kita Y, Shimizu T, Shindou H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Aug;34(8):10357-10372

Targeting PLIN2/PLIN5-PPARγ: Sulforaphane Disturbs the Maturation of Lipid Droplets.

Tian S, Lei P, Teng C, Sun Y, Song X, Li B, Shan Y
Molecular nutrition & food research 2019 Oct;63(20):e1900183

Delayed recruiting of TPD52 to lipid droplets - evidence for a "second wave" of lipid droplet-associated proteins that respond to altered lipid storage induced by Brefeldin A treatment.

Chen Y, Frost S, Khushi M, Cantrill LC, Yu H, Arthur JW, Bright RK, Groblewski GE, Byrne JA
Scientific reports 2019 Jul 5;9(1):9790

Seipin Facilitates Triglyceride Flow to Lipid Droplet and Counteracts Droplet Ripening via Endoplasmic Reticulum Contact.

Salo VT, Li S, Vihinen H, Hölttä-Vuori M, Szkalisity A, Horvath P, Belevich I, Peränen J, Thiele C, Somerharju P, Zhao H, Santinho A, Thiam AR, Jokitalo E, Ikonen E
Developmental cell 2019 Aug 19;50(4):478-493.e9

Syntaxin 17 promotes lipid droplet formation by regulating the distribution of acyl-CoA synthetase 3.

Kimura H, Arasaki K, Ohsaki Y, Fujimoto T, Ohtomo T, Yamada J, Tagaya M
Journal of lipid research 2018 May;59(5):805-819

Lysosomal dysfunction and early glial activation are involved in the pathogenesis of spinocerebellar ataxia type 21 caused by mutant transmembrane protein 240.

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Neurobiology of disease 2018 Dec;120:34-50

AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity.

Luo H, Jiang M, Lian G, Liu Q, Shi M, Li TY, Song L, Ye J, He Y, Yao L, Zhang C, Lin ZZ, Zhang CS, Zhao TJ, Jia WP, Li P, Lin SY, Lin SC
Cell metabolism 2018 Apr 3;27(4):843-853.e6

The lipid droplet-associated protein perilipin 3 facilitates hepatitis C virus-driven hepatic steatosis.

Ferguson D, Zhang J, Davis MA, Helsley RN, Vedin LL, Lee RG, Crooke RM, Graham MJ, Allende DS, Parini P, Brown JM
Journal of lipid research 2017 Feb;58(2):420-432

COPI-TRAPPII activates Rab18 and regulates its lipid droplet association.

Li C, Luo X, Zhao S, Siu GK, Liang Y, Chan HC, Satoh A, Yu SS
The EMBO journal 2017 Feb 15;36(4):441-457

CIDEC/FSP27 is regulated by peroxisome proliferator-activated receptor alpha and plays a critical role in fasting- and diet-induced hepatosteatosis.

Langhi C, Baldán Á
Hepatology (Baltimore, Md.) 2015 Apr;61(4):1227-38

HCV core residues critical for infectivity are also involved in core-NS5A complex formation.

Gawlik K, Baugh J, Chatterji U, Lim PJ, Bobardt MD, Gallay PA
PloS one 2014;9(2):e88866

Perilipin-5 is regulated by statins and controls triglyceride contents in the hepatocyte.

Langhi C, Marquart TJ, Allen RM, Baldán A
Journal of hepatology 2014 Aug;61(2):358-65

IRG and GBP host resistance factors target aberrant, "non-self" vacuoles characterized by the missing of "self" IRGM proteins.

Haldar AK, Saka HA, Piro AS, Dunn JD, Henry SC, Taylor GA, Frickel EM, Valdivia RH, Coers J
PLoS pathogens 2013;9(6):e1003414

A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover.

Eastman SW, Yassaee M, Bieniasz PD
The Journal of cell biology 2009 Mar 23;184(6):881-94

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 10694-1-AP(M6PRBP1 antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: IP Result of anti-M6PRBP1 (IP:10694-1-AP, 3ug; Detection:10694-1-AP 1:1000) with HeLa cells lysate 1000ug.
Sample type: cell line