Antibody data
- Antibody Data
- Antigen structure
- References [23]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 14994-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14994-1-AP, RRID:AB_2142013
- Product name
- METTL1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated METTL1 antibody (Cat. #14994-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Metabolic reprogramming driven by METTL1-mediated tRNA m7G modification promotes acquired anlotinib resistance in oral squamous cell carcinoma.
WDR4 promotes HCC pathogenesis through N(7)-methylguanosine by regulating and interacting with METTL1.
M(7)G modification of FTH1 and pri-miR-26a regulates ferroptosis and chemotherapy resistance in osteosarcoma.
METTL1 mediated tRNA m(7)G modification promotes leukaemogenesis of AML via tRNA regulated translational control.
RNA-related DNA damage and repair: The role of N7-methylguanosine in the cell nucleus exposed to UV light.
Mettl1-mediated internal m(7)G methylation of Sptbn2 mRNA elicits neurogenesis and anti-alzheimer's disease.
METTL1/WDR4-mediated tRNA m(7)G modification and mRNA translation control promote oncogenesis and doxorubicin resistance.
QKI shuttles internal m(7)G-modified transcripts into stress granules and modulates mRNA metabolism.
Structural basis of regulated m(7)G tRNA modification by METTL1-WDR4.
A Comprehensive Analysis of METTL1 to Immunity and Stemness in Pan-Cancer.
METTL1 promotes neuroblastoma development through m(7)G tRNA modification and selective oncogenic gene translation.
METTL1 drives tumor progression of bladder cancer via degrading ATF3 mRNA in an m(7)G-modified miR-760-dependent manner.
Aberrant translation regulated by METTL1/WDR4-mediated tRNA N7-methylguanosine modification drives head and neck squamous cell carcinoma progression.
N(7)-methylguanosine tRNA modification promotes esophageal squamous cell carcinoma tumorigenesis via the RPTOR/ULK1/autophagy axis.
SMYD3 associates with the NuRD (MTA1/2) complex to regulate transcription and promote proliferation and invasiveness in hepatocellular carcinoma cells.
Prognostic role of METTL1 in glioma.
METTL1/WDR4-mediated m(7)G tRNA modifications and m(7)G codon usage promote mRNA translation and lung cancer progression.
N(7)-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression.
METTL1-mediated m(7)G modification of Arg-TCT tRNA drives oncogenic transformation.
Methyltransferase-like 1 regulates lung adenocarcinoma A549 cell proliferation and autophagy via the AKT/mTORC1 signaling pathway.
Dynamic methylome of internal mRNA N(7)-methylguanosine and its regulatory role in translation.
Mettl1/Wdr4-Mediated m(7)G tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation.
tRNA modifying enzymes, NSUN2 and METTL1, determine sensitivity to 5-fluorouracil in HeLa cells.
Chen J, Zhou Q, Li S, Ling R, Zhao Y, Chen D, Wang A, Cao Y
Translational research : the journal of laboratory and clinical medicine 2024 Jun;268:28-39
Translational research : the journal of laboratory and clinical medicine 2024 Jun;268:28-39
WDR4 promotes HCC pathogenesis through N(7)-methylguanosine by regulating and interacting with METTL1.
Dong R, Wang C, Tang B, Cheng Y, Peng X, Yang X, Ni B, Li J
Cellular signalling 2024 Jun;118:111145
Cellular signalling 2024 Jun;118:111145
M(7)G modification of FTH1 and pri-miR-26a regulates ferroptosis and chemotherapy resistance in osteosarcoma.
He M, Wang Y, Xie J, Pu J, Shen Z, Wang A, Li T, Wang T, Li G, Liu Y, Mei Z, Ren Z, Wang W, Liu X, Hong J, Liu Q, Lei H, He X, Du W, Yuan Y, Yang L
Oncogene 2024 Jan;43(5):341-353
Oncogene 2024 Jan;43(5):341-353
METTL1 mediated tRNA m(7)G modification promotes leukaemogenesis of AML via tRNA regulated translational control.
Zhao P, Xia L, Chen D, Xu W, Guo H, Xu Y, Yan B, Wu X, Li Y, Zhang Y, Zhang X
Experimental hematology & oncology 2024 Jan 24;13(1):8
Experimental hematology & oncology 2024 Jan 24;13(1):8
RNA-related DNA damage and repair: The role of N7-methylguanosine in the cell nucleus exposed to UV light.
Stixová L, Tichý V, Bártová E
Heliyon 2024 Feb 29;10(4):e25599
Heliyon 2024 Feb 29;10(4):e25599
Mettl1-mediated internal m(7)G methylation of Sptbn2 mRNA elicits neurogenesis and anti-alzheimer's disease.
Li Q, Liu H, Li L, Guo H, Xie Z, Kong X, Xu J, Zhang J, Chen Y, Zhang Z, Liu J, Xuan A
Cell & bioscience 2023 Oct 1;13(1):183
Cell & bioscience 2023 Oct 1;13(1):183
METTL1/WDR4-mediated tRNA m(7)G modification and mRNA translation control promote oncogenesis and doxorubicin resistance.
Wang Z, Yu P, Zou Y, Ma J, Han H, Wei W, Yang C, Zheng S, Guo S, Wang J, Liu L, Lin S
Oncogene 2023 Jun;42(23):1900-1912
Oncogene 2023 Jun;42(23):1900-1912
QKI shuttles internal m(7)G-modified transcripts into stress granules and modulates mRNA metabolism.
Zhao Z, Qing Y, Dong L, Han L, Wu D, Li Y, Li W, Xue J, Zhou K, Sun M, Tan B, Chen Z, Shen C, Gao L, Small A, Wang K, Leung K, Zhang Z, Qin X, Deng X, Xia Q, Su R, Chen J
Cell 2023 Jul 20;186(15):3208-3226.e27
Cell 2023 Jul 20;186(15):3208-3226.e27
Structural basis of regulated m(7)G tRNA modification by METTL1-WDR4.
Li J, Wang L, Hahn Q, Nowak RP, Viennet T, Orellana EA, Roy Burman SS, Yue H, Hunkeler M, Fontana P, Wu H, Arthanari H, Fischer ES, Gregory RI
Nature 2023 Jan;613(7943):391-397
Nature 2023 Jan;613(7943):391-397
A Comprehensive Analysis of METTL1 to Immunity and Stemness in Pan-Cancer.
Gao Z, Xu J, Zhang Z, Fan Y, Xue H, Guo X, Deng L, Wang S, Zhao R, Zhang P, Li G
Frontiers in immunology 2022;13:795240
Frontiers in immunology 2022;13:795240
METTL1 promotes neuroblastoma development through m(7)G tRNA modification and selective oncogenic gene translation.
Huang Y, Ma J, Yang C, Wei P, Yang M, Han H, Chen HD, Yue T, Xiao S, Chen X, Li Z, Tang Y, Luo J, Lin S, Huang L
Biomarker research 2022 Sep 7;10(1):68
Biomarker research 2022 Sep 7;10(1):68
METTL1 drives tumor progression of bladder cancer via degrading ATF3 mRNA in an m(7)G-modified miR-760-dependent manner.
Xie H, Wang M, Yu H, Wang H, Ding L, Wang R, Luo W, Lu Z, Zheng Q, Ren L, Zhou Z, Su W, Xia L, Li G
Cell death discovery 2022 Nov 17;8(1):458
Cell death discovery 2022 Nov 17;8(1):458
Aberrant translation regulated by METTL1/WDR4-mediated tRNA N7-methylguanosine modification drives head and neck squamous cell carcinoma progression.
Chen J, Li K, Chen J, Wang X, Ling R, Cheng M, Chen Z, Chen F, He Q, Li S, Zhang C, Jiang Y, Chen Q, Wang A, Chen D
Cancer communications (London, England) 2022 Mar;42(3):223-244
Cancer communications (London, England) 2022 Mar;42(3):223-244
N(7)-methylguanosine tRNA modification promotes esophageal squamous cell carcinoma tumorigenesis via the RPTOR/ULK1/autophagy axis.
Han H, Yang C, Ma J, Zhang S, Zheng S, Ling R, Sun K, Guo S, Huang B, Liang Y, Wang L, Chen S, Wang Z, Wei W, Huang Y, Peng H, Jiang YZ, Choe J, Lin S
Nature communications 2022 Mar 18;13(1):1478
Nature communications 2022 Mar 18;13(1):1478
SMYD3 associates with the NuRD (MTA1/2) complex to regulate transcription and promote proliferation and invasiveness in hepatocellular carcinoma cells.
Yang Y, Qiu R, Zhao S, Shen L, Tang B, Weng Q, Xu Z, Zheng L, Chen W, Shu G, Wang Y, Zhao Z, Chen M, Ji J
BMC biology 2022 Dec 27;20(1):294
BMC biology 2022 Dec 27;20(1):294
Prognostic role of METTL1 in glioma.
Li L, Yang Y, Wang Z, Xu C, Huang J, Li G
Cancer cell international 2021 Nov 27;21(1):633
Cancer cell international 2021 Nov 27;21(1):633
METTL1/WDR4-mediated m(7)G tRNA modifications and m(7)G codon usage promote mRNA translation and lung cancer progression.
Ma J, Han H, Huang Y, Yang C, Zheng S, Cai T, Bi J, Huang X, Liu R, Huang L, Luo Y, Li W, Lin S
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Dec 1;29(12):3422-3435
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Dec 1;29(12):3422-3435
N(7)-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression.
Dai Z, Liu H, Liao J, Huang C, Ren X, Zhu W, Zhu S, Peng B, Li S, Lai J, Liang L, Xu L, Peng S, Lin S, Kuang M
Molecular cell 2021 Aug 19;81(16):3339-3355.e8
Molecular cell 2021 Aug 19;81(16):3339-3355.e8
METTL1-mediated m(7)G modification of Arg-TCT tRNA drives oncogenic transformation.
Orellana EA, Liu Q, Yankova E, Pirouz M, De Braekeleer E, Zhang W, Lim J, Aspris D, Sendinc E, Garyfallos DA, Gu M, Ali R, Gutierrez A, Mikutis S, Bernardes GJL, Fischer ES, Bradley A, Vassiliou GS, Slack FJ, Tzelepis K, Gregory RI
Molecular cell 2021 Aug 19;81(16):3323-3338.e14
Molecular cell 2021 Aug 19;81(16):3323-3338.e14
Methyltransferase-like 1 regulates lung adenocarcinoma A549 cell proliferation and autophagy via the AKT/mTORC1 signaling pathway.
Wang C, Wang W, Han X, Du L, Li A, Huang G
Oncology letters 2021 Apr;21(4):330
Oncology letters 2021 Apr;21(4):330
Dynamic methylome of internal mRNA N(7)-methylguanosine and its regulatory role in translation.
Malbec L, Zhang T, Chen YS, Zhang Y, Sun BF, Shi BY, Zhao YL, Yang Y, Yang YG
Cell research 2019 Nov;29(11):927-941
Cell research 2019 Nov;29(11):927-941
Mettl1/Wdr4-Mediated m(7)G tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation.
Lin S, Liu Q, Lelyveld VS, Choe J, Szostak JW, Gregory RI
Molecular cell 2018 Jul 19;71(2):244-255.e5
Molecular cell 2018 Jul 19;71(2):244-255.e5
tRNA modifying enzymes, NSUN2 and METTL1, determine sensitivity to 5-fluorouracil in HeLa cells.
Okamoto M, Fujiwara M, Hori M, Okada K, Yazama F, Konishi H, Xiao Y, Qi G, Shimamoto F, Ota T, Temme A, Tatsuka M
PLoS genetics 2014 Sep;10(9):e1004639
PLoS genetics 2014 Sep;10(9):e1004639
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A2780 cells were subjected to SDS PAGE followed by western blot with 14994-1-AP(METTL1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human gliomas using 14994-1-AP(METTL1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The METTL1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human METTL1. This antibody recognizes human, mouse, rat antigen. The METTL1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.