Antibody data
- Antibody Data
- Antigen structure
- References [159]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 15184-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15184-1-AP, RRID:AB_2084676
- Product name
- CPT1A antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CPT1A antibody (Cat. #15184-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Constituents of Morus alba var. multicaulis leaf improve lipid metabolism by activating the AMPK signaling pathway in HepG2 cells.
Targeting Cpt1a-Bcl-2 interaction modulates apoptosis resistance and fibrotic remodeling.
Succinylation Regulators Promote Clear Cell Renal Cell Carcinoma by Immune Regulation and RNA N6-Methyladenosine Methylation.
Dendrobium officinale Regulates Fatty Acid Metabolism to Ameliorate Liver Lipid Accumulation in NAFLD Mice.
ZLN005 protects against ischemia-reperfusion-induced kidney injury by mitigating oxidative stress through the restoration of mitochondrial fatty acid oxidation.
Endoplasmic Reticulum Stress Disturbs Lipid Homeostasis and Augments Inflammation in the Intestine and Isolated Intestinal Cells of Large Yellow Croaker (Larimichthys crocea).
Mitofusin 2 Deficiency Causes Pro-Inflammatory Effects in Human Primary Macrophages.
Lysosome-Dependent LXR and PPARδ Activation Upon Efferocytosis in Human Macrophages.
Effects of High Levels of Dietary Linseed Oil on the Growth Performance, Antioxidant Capacity, Hepatic Lipid Metabolism, and Expression of Inflammatory Genes in Large Yellow Croaker (Larimichthys crocea).
Daily Dose of Bovine Lactoferrin Prevents Ethanol-Induced Liver Injury and Death in Male Mice by Regulating Hepatic Alcohol Metabolism and Modulating Gut Microbiota.
Pterostilbene attenuates RIPK3-dependent hepatocyte necroptosis in alcoholic liver disease via SIRT2-mediated NFATc4 deacetylation.
CPT1A and fatty acid β-oxidation are essential for tumor cell growth and survival in hormone receptor-positive breast cancer.
Live Combined B. subtilis and E. faecium Alleviate Liver Inflammation, Improve Intestinal Barrier Function, and Modulate Gut Microbiota in Mice with Non-Alcoholic Fatty Liver Disease.
Exposure to ethephon compromises endometrial decidualization in mice during early pregnancy via GPR120.
Dihydroartemisinin regulates lipid droplet metabolism in hepatic stellate cells by inhibiting lncRNA-H19-induced AMPK signal.
Bioactive flavonoids and stilbenes from the leaf of Morus alba var. multicaulis.
Exercise promotes angiogenesis by enhancing endothelial cell fatty acid utilization via liver-derived extracellular vesicle miR-122-5p.
Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2.
Isoliquiritigenin-mediated miR-23a-3p inhibition activates PGC-1α to alleviate alcoholic liver injury.
The modified mitochondrial outer membrane carrier MTCH2 links mitochondrial fusion to lipogenesis.
High-fat diet-induced obesity primes fatty acid β-oxidation impairment and consequent ovarian dysfunction during early pregnancy.
Danthron ameliorates obesity and MAFLD through activating the interplay between PPARα/RXRα heterodimer and adiponectin receptor 2.
Simultaneously targeting SOAT1 and CPT1A ameliorates hepatocellular carcinoma by disrupting lipid homeostasis.
Apple polyphenol extract alleviates lipid accumulation in free-fatty-acid-exposed HepG2 cells via activating autophagy mediated by SIRT1/AMPK signaling.
Glioma cells survival depends both on fatty acid oxidation and on functional carnitine transport by SLC22A5.
FGF1ΔHBS prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK/Nur77 suppression.
Effect of selenium-enriched kiwifruit on body fat reduction and liver protection in hyperlipidaemic mice.
Icaritin ameliorates hepatic steatosis via promoting fatty acid β-oxidation and insulin sensitivity.
Marein ameliorates Ang II/hypoxia-induced abnormal glucolipid metabolism by modulating the HIF-1α/PPARα/γ pathway in H9c2 cells.
Deficiency of Mitochondrial Glycerol 3-Phosphate Dehydrogenase Exacerbates Podocyte Injury and the Progression of Diabetic Kidney Disease.
Chronic angiotensin receptor activation promotes hepatic triacylglycerol accumulation during an acute glucose challenge in obese-insulin-resistant OLETF rats.
Carbohydrate response element-binding protein regulates lipid metabolism via mTOR complex1 in diabetic nephropathy.
Skip participates in formation and lipid metabolism of beige adipose and might mediate the effects of SIRT1 activator BTM-0512 on beige remodeling.
Proteomic Analysis Reveals the Effect of Trichostatin A and Bone Marrow-Derived Dendritic Cells on the Fatty Acid Metabolism of NIH3T3 Cells under Oxygen-Glucose Deprivation Conditions.
Cordycepin attenuates high-fat diet-induced non-alcoholic fatty liver disease via down-regulation of lipid metabolism and inflammatory responses.
Roles of acyl-CoA synthetase long-chain family member 5 and colony stimulating factor 2 in inhibition of palmitic or stearic acids in lung cancer cell proliferation and metabolism.
HRD1 inhibits fatty acid oxidation and tumorigenesis by ubiquitinating CPT2 in triple-negative breast cancer.
Gentisic acid prevents diet-induced obesity in mice by accelerating the thermogenesis of brown adipose tissue.
18β-glycyrrhetinic acid improves high-intensity exercise performance by promoting glucose-dependent energy production and inhibiting oxidative stress in mice.
NMR-based untargeted metabolomics approach to investigate the systemic lipid metabolism regulation of norisoboldine in collagen-induced arthritis rats.
GEO data mining and TCGA analysis reveal altered branched chain amino acid metabolism in pancreatic cancer patients.
Echinacoside improves diabetic liver injury by regulating the AMPK/SIRT1 signaling pathway in db/db mice.
The Role of GPR109a Signaling in Niacin Induced Effects on Fed and Fasted Hepatic Metabolism.
Tributyrin Inhibits Ethanol-Induced Epigenetic Repression of CPT-1A and Attenuates Hepatic Steatosis and Injury.
Mogroside V Protects against Hepatic Steatosis in Mice on a High-Fat Diet and LO2 Cells Treated with Free Fatty Acids via AMPK Activation.
Mild Hypothermia Attenuates Hepatic Ischemia-Reperfusion Injury through Regulating the JAK2/STAT3-CPT1a-Dependent Fatty Acid β-Oxidation.
TET1 promotes fatty acid oxidation and inhibits NAFLD progression by hydroxymethylation of PPARα promoter.
Effects of canagliflozin on growth and metabolic reprograming in hepatocellular carcinoma cells: Multi-omics analysis of metabolomics and absolute quantification proteomics (iMPAQT).
UCHL1 regulates oxidative activity in skeletal muscle.
Fenofibrate-induced mitochondrial dysfunction and metabolic reprogramming reversal: the anti-tumor effects in gastric carcinoma cells mediated by the PPAR pathway.
High-Intensity Interval Training Restores Glycolipid Metabolism and Mitochondrial Function in Skeletal Muscle of Mice With Type 2 Diabetes.
Critical biomarkers for myocardial damage by fine particulate matter: Focused on PPARα-regulated energy metabolism.
Sirtuin 3-mediated deacetylation of acyl-CoA synthetase family member 3 by protocatechuic acid attenuates non-alcoholic fatty liver disease.
SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Body-Induced mTORC1 Inhibition.
Uncovering the mechanism of Astragali Radix against nephrotic syndrome by intergrating lipidomics and network pharmacology.
Peroxisomal proliferator-activated receptor α-b deficiency induces the reprogramming of nutrient metabolism in zebrafish.
Protective effect of Yi-Qi-Huo-Xue Decoction against ischemic heart disease by regulating cardiac lipid metabolism.
A substrate-trapping strategy to find E3 ubiquitin ligase substrates identifies Parkin and TRIM28 targets.
A novel bile acid analog, A17, ameliorated non-alcoholic steatohepatitis in high-fat diet-fed hamsters.
Effect and mechanism of ginsenoside Rg1-regulating hepatic steatosis in HepG2 cells induced by free fatty acid.
Melanoma Persister Cells Are Tolerant to BRAF/MEK Inhibitors via ACOX1-Mediated Fatty Acid Oxidation.
CPT1A Over-Expression Increases Reactive Oxygen Species in the Mitochondria and Promotes Antioxidant Defenses in Prostate Cancer.
RIPK3 Orchestrates Fatty Acid Metabolism in Tumor-Associated Macrophages and Hepatocarcinogenesis.
Sirt3 modulates fatty acid oxidation and attenuates cisplatin-induced AKI in mice.
Modulation of SIRT1-mediated signaling cascades in the liver contributes to the amelioration of nonalcoholic steatohepatitis in high fat fed middle-aged LDL receptor knockout mice by dihydromyricetin.
Yin Zhi Huang, a traditional Chinese herbal formula, ameliorates diet-induced obesity and hepatic steatosis by activating the AMPK/SREBP-1 and the AMPK/ACC/CPT1A pathways.
Low Expression of Sirtuin 1 in the Dairy Cows with Mild Fatty Liver Alters Hepatic Lipid Metabolism.
Prohibitin 2 deficiency impairs cardiac fatty acid oxidation and causes heart failure.
Severe hypoglycemia exacerbates myocardial dysfunction and metabolic remodeling in diabetic mice.
Hepatic HuR modulates lipid homeostasis in response to high-fat diet.
Identification of FABP5 as an immunometabolic marker in human hepatocellular carcinoma.
Spexin protects cardiomyocytes from hypoxia-induced metabolic and mitochondrial dysfunction.
Flavonoids extracted from mulberry (Morus alba L.) leaf improve skeletal muscle mitochondrial function by activating AMPK in type 2 diabetes.
Hepatic Synaptotagmin 1 is involved in the remodelling of liver plasma- membrane lipid composition and gene expression in male Apoe-deficient mice consuming a Western diet.
Dynamic Cardiolipin Synthesis Is Required for CD8+ T Cell Immunity.
Hypertensive Rats Treated Chronically With Nω-Nitro-L-Arginine Methyl Ester (L-NAME) Induced Disorder of Hepatic Fatty Acid Metabolism and Intestinal Pathophysiology.
UPLC-QTOF/MS-based metabolomics analysis of plasma reveals an effect of Xue-Fu-Zhu-Yu capsules on blood-stasis syndrome in CHD rats.
Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1.
The contrary intracellular and extracellular functions of PEDF in HCC development.
Apple Polyphenol Extract Alleviates High-Fat-Diet-Induced Hepatic Steatosis in Male C57BL/6 Mice by Targeting LKB1/AMPK Pathway.
Loss of ubiquitin-conjugating enzyme E2 (Ubc9) in macrophages exacerbates multiple low-dose streptozotocin-induced diabetes by attenuating M2 macrophage polarization.
Role of ketone signaling in the hepatic response to fasting.
Integrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 Mutation.
MSC-regulated lncRNA MACC1-AS1 promotes stemness and chemoresistance through fatty acid oxidation in gastric cancer.
Impairment of Fatty Acid Oxidation in Alveolar Epithelial Cells Mediates Acute Lung Injury.
Coenzyme Q10 attenuates high-fat diet-induced non-alcoholic fatty liver disease through activation of the AMPK pathway.
Fe3O4@OA@Poloxamer nanoparticles lower triglyceride in hepatocytes through liposuction effect and nano-enzyme effect.
Adropin reduces blood glucose levels in mice by limiting hepatic glucose production.
CD36 plays a negative role in the regulation of lipophagy in hepatocytes through an AMPK-dependent pathway.
Inhibition of soluble epoxide hydrolase ameliorates hyperhomocysteinemia-induced hepatic steatosis by enhancing β-oxidation of fatty acid in mice.
A novel approach to target hypoxic cancer cells via combining β-oxidation inhibitor etomoxir with radiation.
GLP-1 receptor agonist ameliorates obesity-induced chronic kidney injury via restoring renal metabolism homeostasis.
Combinatorial treatment of Rhizoma Paridis saponins and sorafenib overcomes the intolerance of sorafenib.
YAP1 enhances NF-κB-dependent and independent effects on clock-mediated unfolded protein responses and autophagy in sarcoma.
Rosiglitazone ameliorates palmitic acid-induced cytotoxicity in TM4 Sertoli cells.
The protein acetylase GCN5L1 modulates hepatic fatty acid oxidation activity via acetylation of the mitochondrial β-oxidation enzyme HADHA.
IL-25 stimulates M2 macrophage polarization and thereby promotes mitochondrial respiratory capacity and lipolysis in adipose tissues against obesity.
Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.
Fibroblast growth factor 21 increases hepatic oxidative capacity but not physical activity or energy expenditure in hepatic peroxisome proliferator-activated receptor γ coactivator-1α-deficient mice.
Scutellaria baicalensis regulates FFA metabolism to ameliorate NAFLD through the AMPK-mediated SREBP signaling pathway.
Disrupting SOD1 activity inhibits cell growth and enhances lipid accumulation in nasopharyngeal carcinoma.
Chronic low-dose exposure of nonylphenol alters energy homeostasis in the reproductive system of female rats.
N-3 polyunsaturated fatty acids ameliorate hepatic steatosis via the PPAR-α/CPT-1α pathway in a mouse model of parenteral nutrition.
Polyacetylene glycoside attenuates ischemic kidney injury by co-inhibiting inflammation, mitochondria dysfunction and lipotoxicity.
Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity.
PIK3R3 regulates PPARα expression to stimulate fatty acid β-oxidation and decrease hepatosteatosis.
Adipose-specific lipin1 overexpression in mice protects against alcohol-induced liver injury.
Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis.
Paeoniflorin Ameliorates Fructose-Induced Insulin Resistance and Hepatic Steatosis by Activating LKB1/AMPK and AKT Pathways.
Mitochondria-targeted ubiquinone (MitoQ) enhances acetaldehyde clearance by reversing alcohol-induced posttranslational modification of aldehyde dehydrogenase 2: A molecular mechanism of protection against alcoholic liver disease.
Fish oil feeding reverses hepatomegaly and disrupted hepatic function due to the lack of FXR signaling.
A signature of enhanced lipid metabolism, lipid peroxidation and aldehyde stress in therapy-induced senescence.
Kupffer cells activation promoted binge drinking-induced fatty liver by activating lipolysis in white adipose tissues.
Attenuation of hepatic steatosis by purple sweet potato colour is associated with blocking Src/ERK/C/EBPβ signalling in high-fat-diet-treated mice.
Mitochondrial Priming by CD28.
p38α MAPK antagonizing JNK to control the hepatic fat accumulation in pediatric patients onset intestinal failure.
Targeted Metabolomics Reveals Abnormal Hepatic Energy Metabolism by Depletion of β-Carotene Oxygenase 2 in Mice.
Xyloketal B Attenuates Fatty Acid-Induced Lipid Accumulation via the SREBP-1c Pathway in NAFLD Models.
Aerobic capacity mediates susceptibility for the transition from steatosis to steatohepatitis.
Pharmacological inhibition of NOX4 ameliorates alcohol-induced liver injury in mice through improving oxidative stress and mitochondrial function.
Calycosin attenuates triglyceride accumulation and hepatic fibrosis in murine model of non-alcoholic steatohepatitis via activating farnesoid X receptor.
RNA Binding Protein Ybx2 Regulates RNA Stability During Cold-Induced Brown Fat Activation.
Lipid catabolism inhibition sensitizes prostate cancer cells to antiandrogen blockade.
Hepatic overproduction of 13-HODE due to ALOX15 upregulation contributes to alcohol-induced liver injury in mice.
Medium-chain fatty acid reduces lipid accumulation by regulating expression of lipid-sensing genes in human liver cells with steatosis.
Dysregulation of hepatic cAMP levels via altered Pde4b expression plays a critical role in alcohol-induced steatosis.
Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer.
High-fat diet enhances stemness and tumorigenicity of intestinal progenitors.
TXNIP regulates myocardial fatty acid oxidation via miR-33a signaling.
Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice.
HDAC4 mediates IFN-γ induced disruption of energy expenditure-related gene expression by repressing SIRT1 transcription in skeletal muscle cells.
Foxp3 and Toll-like receptor signaling balance T(reg) cell anabolic metabolism for suppression.
A Novel Function of Hepatic FOG2 in Insulin Sensitivity and Lipid Metabolism Through PPARα.
Acetyl-coenzyme A carboxylase alpha promotion of glucose-mediated fatty acid synthesis enhances survival of hepatocellular carcinoma in mice and patients.
Diet rich in Docosahexaenoic Acid/Eicosapentaenoic Acid robustly ameliorates hepatic steatosis and insulin resistance in seipin deficient lipodystrophy mice.
Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease.
AMP-Activated Protein Kinase Interacts with the Peroxisome Proliferator-Activated Receptor Delta to Induce Genes Affecting Fatty Acid Oxidation in Human Macrophages.
Niche-dependent regulations of metabolic balance in high-fat diet-induced diabetic mice by mesenchymal stromal cells.
Proteomics-based metabolic modeling reveals that fatty acid oxidation (FAO) controls endothelial cell (EC) permeability.
Astrocyte Elevated Gene-1 (AEG-1) Regulates Lipid Homeostasis.
High metastaticgastric and breast cancer cells consume oleic acid in an AMPK dependent manner.
Fatty acid oxidation is dispensable for human macrophage IL-4-induced polarization.
HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression.
A compound heterozygous mutation in GPD1 causes hepatomegaly, steatohepatitis, and hypertriglyceridemia.
Inhibition of macrophage fatty acid β-oxidation exacerbates palmitate-induced inflammatory and endoplasmic reticulum stress responses.
Identification of 5' AMP-activated kinase as a target of reactive aldehydes during chronic ingestion of high concentrations of ethanol.
SIRT1 activation by methylene blue, a repurposed drug, leads to AMPK-mediated inhibition of steatosis and steatohepatitis.
KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance.
Chinese medicine formula lingguizhugan decoction improves Beta-oxidation and metabolism of Fatty Acid in high-fat-diet-induced rat model of Fatty liver disease.
Binge ethanol-induced HDAC3 down-regulates Cpt1α expression leading to hepatic steatosis and injury.
Anti-miR-33 therapy does not alter the progression of atherosclerosis in low-density lipoprotein receptor-deficient mice.
An iTRAQ proteomic study reveals an association between diet-induced enhanced fatty acid metabolism and the development of glucose intolerance in prediabetic mice.
Role of sirtuin 1 in the regulation of hepatic gene expression by thyroid hormone.
SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.
An active metabolite of oltipraz (M2) increases mitochondrial fuel oxidation and inhibits lipogenesis in the liver by dually activating AMPK.
Binge alcohol-induced microvesicular liver steatosis and injury are associated with down-regulation of hepatic Hdac 1, 7, 9, 10, 11 and up-regulation of Hdac 3.
Genomic alterations with impact on survival in esophageal squamous cell carcinoma identified by array comparative genomic hybridization.
Establishing a relationship between prolactin and altered fatty acid β-oxidation via carnitine palmitoyl transferase 1 in breast cancer cells.
Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation.
Huang P, Hao M, Gao Q, Ruan J, Yang S, Liu M, Chen Q, Zhang Y, Wang T
Journal of natural medicines 2022 Jan;76(1):200-209
Journal of natural medicines 2022 Jan;76(1):200-209
Targeting Cpt1a-Bcl-2 interaction modulates apoptosis resistance and fibrotic remodeling.
Gu L, Surolia R, Larson-Casey JL, He C, Davis D, Kang J, Antony VB, Carter AB
Cell death and differentiation 2022 Jan;29(1):118-132
Cell death and differentiation 2022 Jan;29(1):118-132
Succinylation Regulators Promote Clear Cell Renal Cell Carcinoma by Immune Regulation and RNA N6-Methyladenosine Methylation.
Lu W, Che X, Qu X, Zheng C, Yang X, Bao B, Li Z, Wang D, Jin Y, Wang Y, Xiao J, Qi J, Liu Y
Frontiers in cell and developmental biology 2021;9:622198
Frontiers in cell and developmental biology 2021;9:622198
Dendrobium officinale Regulates Fatty Acid Metabolism to Ameliorate Liver Lipid Accumulation in NAFLD Mice.
Lei SS, Zhang NY, Zhou FC, He X, Wang HY, Li LZ, Zheng X, Dong YJ, Luo R, Li B, Jin HY, Yu QX, Lv GY, Chen SH
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6689727
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6689727
ZLN005 protects against ischemia-reperfusion-induced kidney injury by mitigating oxidative stress through the restoration of mitochondrial fatty acid oxidation.
Wang Z, Fu Z, Wang C, Xu J, Ma H, Jiang M, Xu T, Feng X, Zhang W
American journal of translational research 2021;13(9):10014-10037
American journal of translational research 2021;13(9):10014-10037
Endoplasmic Reticulum Stress Disturbs Lipid Homeostasis and Augments Inflammation in the Intestine and Isolated Intestinal Cells of Large Yellow Croaker (Larimichthys crocea).
Fang W, Chen Q, Li J, Liu Y, Zhao Z, Shen Y, Mai K, Ai Q
Frontiers in immunology 2021;12:738143
Frontiers in immunology 2021;12:738143
Mitofusin 2 Deficiency Causes Pro-Inflammatory Effects in Human Primary Macrophages.
Khodzhaeva V, Schreiber Y, Geisslinger G, Brandes RP, Brüne B, Namgaladze D
Frontiers in immunology 2021;12:723683
Frontiers in immunology 2021;12:723683
Lysosome-Dependent LXR and PPARδ Activation Upon Efferocytosis in Human Macrophages.
Mota AC, Dominguez M, Weigert A, Snodgrass RG, Namgaladze D, Brüne B
Frontiers in immunology 2021;12:637778
Frontiers in immunology 2021;12:637778
Effects of High Levels of Dietary Linseed Oil on the Growth Performance, Antioxidant Capacity, Hepatic Lipid Metabolism, and Expression of Inflammatory Genes in Large Yellow Croaker (Larimichthys crocea).
Li X, Chen Q, Li Q, Li J, Cui K, Zhang Y, Kong A, Zhang Y, Wan M, Mai K, Ai Q
Frontiers in physiology 2021;12:631850
Frontiers in physiology 2021;12:631850
Daily Dose of Bovine Lactoferrin Prevents Ethanol-Induced Liver Injury and Death in Male Mice by Regulating Hepatic Alcohol Metabolism and Modulating Gut Microbiota.
Li D, He Q, Yang H, Du Y, Yu K, Yang J, Tong X, Guo Y, Xu J, Qin L
Molecular nutrition & food research 2021 Sep;65(18):e2100253
Molecular nutrition & food research 2021 Sep;65(18):e2100253
Pterostilbene attenuates RIPK3-dependent hepatocyte necroptosis in alcoholic liver disease via SIRT2-mediated NFATc4 deacetylation.
Shao Y, Wang X, Zhou Y, Jiang Y, Wu R, Lu C
Toxicology 2021 Sep;461:152923
Toxicology 2021 Sep;461:152923
CPT1A and fatty acid β-oxidation are essential for tumor cell growth and survival in hormone receptor-positive breast cancer.
Jariwala N, Mehta GA, Bhatt V, Hussein S, Parker KA, Yunus N, Parker JS, Guo JY, Gatza ML
NAR cancer 2021 Sep;3(3):zcab035
NAR cancer 2021 Sep;3(3):zcab035
Live Combined B. subtilis and E. faecium Alleviate Liver Inflammation, Improve Intestinal Barrier Function, and Modulate Gut Microbiota in Mice with Non-Alcoholic Fatty Liver Disease.
Jiang J, Xiong J, Ni J, Chen C, Wang K
Medical science monitor : international medical journal of experimental and clinical research 2021 Sep 5;27:e931143
Medical science monitor : international medical journal of experimental and clinical research 2021 Sep 5;27:e931143
Exposure to ethephon compromises endometrial decidualization in mice during early pregnancy via GPR120.
Huang C, Wang D, Li N, Yang C, Chen X, Liu X, He J, Ding Y, Tong C, Peng C, Li F, Wang Y, Gao R
Ecotoxicology and environmental safety 2021 Sep 1;220:112361
Ecotoxicology and environmental safety 2021 Sep 1;220:112361
Dihydroartemisinin regulates lipid droplet metabolism in hepatic stellate cells by inhibiting lncRNA-H19-induced AMPK signal.
Xia S, Wang Z, Chen L, Zhou Y, Li Y, Wang S, Chen A, Xu X, Shao J, Zhang Z, Tan S, Zhang F, Zheng S
Biochemical pharmacology 2021 Oct;192:114730
Biochemical pharmacology 2021 Oct;192:114730
Bioactive flavonoids and stilbenes from the leaf of Morus alba var. multicaulis.
Hao M, Huang P, Ruan J, Sun F, Han L, Liu M, Zhang Y, Wang T
Fitoterapia 2021 Oct;154:105018
Fitoterapia 2021 Oct;154:105018
Exercise promotes angiogenesis by enhancing endothelial cell fatty acid utilization via liver-derived extracellular vesicle miR-122-5p.
Lou J, Wu J, Feng M, Dang X, Wu G, Yang H, Wang Y, Li J, Zhao Y, Shi C, Liu J, Zhao L, Zhang X, Gao F
Journal of sport and health science 2021 Oct 1;
Journal of sport and health science 2021 Oct 1;
Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2.
Chella Krishnan K, Vergnes L, Acín-Pérez R, Stiles L, Shum M, Ma L, Mouisel E, Pan C, Moore TM, Péterfy M, Romanoski CE, Reue K, Björkegren JLM, Laakso M, Liesa M, Lusis AJ
Nature metabolism 2021 Nov;3(11):1552-1568
Nature metabolism 2021 Nov;3(11):1552-1568
Isoliquiritigenin-mediated miR-23a-3p inhibition activates PGC-1α to alleviate alcoholic liver injury.
Wang L, Kong L, Xu S, Wang X, Huang K, Wang S, Wu J, Wang C, Sun H, Liu K, Meng Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Nov 5;:153845
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Nov 5;:153845
The modified mitochondrial outer membrane carrier MTCH2 links mitochondrial fusion to lipogenesis.
Labbé K, Mookerjee S, Le Vasseur M, Gibbs E, Lerner C, Nunnari J
The Journal of cell biology 2021 Nov 1;220(11)
The Journal of cell biology 2021 Nov 1;220(11)
High-fat diet-induced obesity primes fatty acid β-oxidation impairment and consequent ovarian dysfunction during early pregnancy.
Li Q, Guo S, Yang C, Liu X, Chen X, He J, Tong C, Ding Y, Peng C, Geng Y, Mu X, Liu T, Li F, Wang Y, Gao R
Annals of translational medicine 2021 May;9(10):887
Annals of translational medicine 2021 May;9(10):887
Danthron ameliorates obesity and MAFLD through activating the interplay between PPARα/RXRα heterodimer and adiponectin receptor 2.
Ma C, Wang Z, Xia R, Wei L, Zhang C, Zhang J, Zhao L, Wu H, Kang L, Yang S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 May;137:111344
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 May;137:111344
Simultaneously targeting SOAT1 and CPT1A ameliorates hepatocellular carcinoma by disrupting lipid homeostasis.
Ren M, Xu H, Xia H, Tang Q, Bi F
Cell death discovery 2021 May 29;7(1):125
Cell death discovery 2021 May 29;7(1):125
Apple polyphenol extract alleviates lipid accumulation in free-fatty-acid-exposed HepG2 cells via activating autophagy mediated by SIRT1/AMPK signaling.
Li D, Cui Y, Wang X, Liu F, Li X
Phytotherapy research : PTR 2021 Mar;35(3):1416-1431
Phytotherapy research : PTR 2021 Mar;35(3):1416-1431
Glioma cells survival depends both on fatty acid oxidation and on functional carnitine transport by SLC22A5.
Juraszek B, Czarnecka-Herok J, Nałęcz KA
Journal of neurochemistry 2021 Mar;156(5):642-657
Journal of neurochemistry 2021 Mar;156(5):642-657
FGF1ΔHBS prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK/Nur77 suppression.
Wang D, Yin Y, Wang S, Zhao T, Gong F, Zhao Y, Wang B, Huang Y, Cheng Z, Zhu G, Wang Z, Wang Y, Ren J, Liang G, Li X, Huang Z
Signal transduction and targeted therapy 2021 Mar 24;6(1):133
Signal transduction and targeted therapy 2021 Mar 24;6(1):133
Effect of selenium-enriched kiwifruit on body fat reduction and liver protection in hyperlipidaemic mice.
Zhang X, Xia H, Wang J, Leng R, Zhou X, Gao Q, He K, Liu D, Huang B
Food & function 2021 Mar 15;12(5):2044-2057
Food & function 2021 Mar 15;12(5):2044-2057
Icaritin ameliorates hepatic steatosis via promoting fatty acid β-oxidation and insulin sensitivity.
Xiong Y, Chen Y, Huang X, Yang Z, Zhang J, Yu X, Fang J, Tao J, You K, Cheng Z, Tan S, Xu Y, Yuan F, Liu Y, Zhuang Y, Yang F, Li Y
Life sciences 2021 Mar 1;268:119000
Life sciences 2021 Mar 1;268:119000
Marein ameliorates Ang II/hypoxia-induced abnormal glucolipid metabolism by modulating the HIF-1α/PPARα/γ pathway in H9c2 cells.
Niu G, Zhou M, Wang F, Yang J, Huang J, Zhu Z
Drug development research 2021 Jun;82(4):523-532
Drug development research 2021 Jun;82(4):523-532
Deficiency of Mitochondrial Glycerol 3-Phosphate Dehydrogenase Exacerbates Podocyte Injury and the Progression of Diabetic Kidney Disease.
Qu H, Gong X, Liu X, Zhang R, Wang Y, Huang B, Zhang L, Zheng H, Zheng Y
Diabetes 2021 Jun;70(6):1372-1387
Diabetes 2021 Jun;70(6):1372-1387
Chronic angiotensin receptor activation promotes hepatic triacylglycerol accumulation during an acute glucose challenge in obese-insulin-resistant OLETF rats.
Godoy-Lugo JA, Thorwald MA, Hui DY, Nishiyama A, Nakano D, Soñanez-Organis JG, Ortiz RM
Endocrine 2021 Jul 29;
Endocrine 2021 Jul 29;
Carbohydrate response element-binding protein regulates lipid metabolism via mTOR complex1 in diabetic nephropathy.
Chen N, Mu L, Yang Z, Du C, Wu M, Song S, Yuan C, Shi Y
Journal of cellular physiology 2021 Jan;236(1):625-640
Journal of cellular physiology 2021 Jan;236(1):625-640
Skip participates in formation and lipid metabolism of beige adipose and might mediate the effects of SIRT1 activator BTM-0512 on beige remodeling.
Liao ZM, Li AN, Cai Y, Chen JJ, Xu Y, Sui LH, Wang JL, Jin P, Wang KS, Yang ZC
Biochemical and biophysical research communications 2021 Jan 22;537:109-117
Biochemical and biophysical research communications 2021 Jan 22;537:109-117
Proteomic Analysis Reveals the Effect of Trichostatin A and Bone Marrow-Derived Dendritic Cells on the Fatty Acid Metabolism of NIH3T3 Cells under Oxygen-Glucose Deprivation Conditions.
Wang X, Song T, Sun Y, Men L, Gu Y, Zhang S, Chen X
Journal of proteome research 2021 Jan 1;20(1):960-971
Journal of proteome research 2021 Jan 1;20(1):960-971
Cordycepin attenuates high-fat diet-induced non-alcoholic fatty liver disease via down-regulation of lipid metabolism and inflammatory responses.
Gong X, Li T, Wan R, Sha L
International immunopharmacology 2021 Feb;91:107173
International immunopharmacology 2021 Feb;91:107173
Roles of acyl-CoA synthetase long-chain family member 5 and colony stimulating factor 2 in inhibition of palmitic or stearic acids in lung cancer cell proliferation and metabolism.
Zhang L, Lv J, Chen C, Wang X
Cell biology and toxicology 2021 Feb;37(1):15-34
Cell biology and toxicology 2021 Feb;37(1):15-34
HRD1 inhibits fatty acid oxidation and tumorigenesis by ubiquitinating CPT2 in triple-negative breast cancer.
Guo X, Wang A, Wang W, Wang Y, Chen H, Liu X, Xia T, Zhang A, Chen D, Qi H, Ling T, Piao HL, Wang HJ
Molecular oncology 2021 Feb;15(2):642-656
Molecular oncology 2021 Feb;15(2):642-656
Gentisic acid prevents diet-induced obesity in mice by accelerating the thermogenesis of brown adipose tissue.
Han X, Guo J, Gao Y, Zhan J, You Y, Huang W
Food & function 2021 Feb 15;12(3):1262-1270
Food & function 2021 Feb 15;12(3):1262-1270
18β-glycyrrhetinic acid improves high-intensity exercise performance by promoting glucose-dependent energy production and inhibiting oxidative stress in mice.
Ma X, Chen H, Cao L, Zhao S, Zhao C, Yin S, Hu H
Phytotherapy research : PTR 2021 Dec;35(12):6932-6943
Phytotherapy research : PTR 2021 Dec;35(12):6932-6943
NMR-based untargeted metabolomics approach to investigate the systemic lipid metabolism regulation of norisoboldine in collagen-induced arthritis rats.
Fang Y, Duan C, Zhang J, Dai Y, Xia Y
European journal of pharmacology 2021 Dec 5;912:174608
European journal of pharmacology 2021 Dec 5;912:174608
GEO data mining and TCGA analysis reveal altered branched chain amino acid metabolism in pancreatic cancer patients.
Li JY, Sun F, Yang CL, Zhou HF, Gao M, Zhang Q, Chen H, Zhou P, Xiao J, Fan H
Aging 2021 Apr 21;13(8):11907-11918
Aging 2021 Apr 21;13(8):11907-11918
Echinacoside improves diabetic liver injury by regulating the AMPK/SIRT1 signaling pathway in db/db mice.
Yang L, Zhang X, Liao M, Hao Y
Life sciences 2021 Apr 15;271:119237
Life sciences 2021 Apr 15;271:119237
The Role of GPR109a Signaling in Niacin Induced Effects on Fed and Fasted Hepatic Metabolism.
Geisler CE, Miller KE, Ghimire S, Renquist BJ
International journal of molecular sciences 2021 Apr 13;22(8)
International journal of molecular sciences 2021 Apr 13;22(8)
Tributyrin Inhibits Ethanol-Induced Epigenetic Repression of CPT-1A and Attenuates Hepatic Steatosis and Injury.
Donde H, Ghare S, Joshi-Barve S, Zhang J, Vadhanam MV, Gobejishvili L, Lorkiewicz P, Srivastava S, McClain CJ, Barve S
Cellular and molecular gastroenterology and hepatology 2020;9(4):569-585
Cellular and molecular gastroenterology and hepatology 2020;9(4):569-585
Mogroside V Protects against Hepatic Steatosis in Mice on a High-Fat Diet and LO2 Cells Treated with Free Fatty Acids via AMPK Activation.
Li L, Zheng W, Wang C, Qi J, Li H
Evidence-based complementary and alternative medicine : eCAM 2020;2020:7826874
Evidence-based complementary and alternative medicine : eCAM 2020;2020:7826874
Mild Hypothermia Attenuates Hepatic Ischemia-Reperfusion Injury through Regulating the JAK2/STAT3-CPT1a-Dependent Fatty Acid β-Oxidation.
Wang W, Hu X, Xia Z, Liu Z, Zhong Z, Lu Z, Liu A, Ye S, Cao Q, Wang Y, Zhu F, Ye Q
Oxidative medicine and cellular longevity 2020;2020:5849794
Oxidative medicine and cellular longevity 2020;2020:5849794
TET1 promotes fatty acid oxidation and inhibits NAFLD progression by hydroxymethylation of PPARα promoter.
Wang J, Zhang Y, Zhuo Q, Tseng Y, Wang J, Ma Y, Zhang J, Liu J
Nutrition & metabolism 2020;17:46
Nutrition & metabolism 2020;17:46
Effects of canagliflozin on growth and metabolic reprograming in hepatocellular carcinoma cells: Multi-omics analysis of metabolomics and absolute quantification proteomics (iMPAQT).
Nakano D, Kawaguchi T, Iwamoto H, Hayakawa M, Koga H, Torimura T
PloS one 2020;15(4):e0232283
PloS one 2020;15(4):e0232283
UCHL1 regulates oxidative activity in skeletal muscle.
Gao H, Antony R, Srinivasan R, Wu P, Wang X, Li Y
PloS one 2020;15(11):e0241716
PloS one 2020;15(11):e0241716
Fenofibrate-induced mitochondrial dysfunction and metabolic reprogramming reversal: the anti-tumor effects in gastric carcinoma cells mediated by the PPAR pathway.
Chen L, Peng J, Wang Y, Jiang H, Wang W, Dai J, Tang M, Wei Y, Kuang H, Xu G, Xu H, Zhou F
American journal of translational research 2020;12(2):428-446
American journal of translational research 2020;12(2):428-446
High-Intensity Interval Training Restores Glycolipid Metabolism and Mitochondrial Function in Skeletal Muscle of Mice With Type 2 Diabetes.
Zheng L, Rao Z, Guo Y, Chen P, Xiao W
Frontiers in endocrinology 2020;11:561
Frontiers in endocrinology 2020;11:561
Critical biomarkers for myocardial damage by fine particulate matter: Focused on PPARα-regulated energy metabolism.
Zhang Z, Su H, Ahmed RZ, Zheng Y, Jin X
Environmental pollution (Barking, Essex : 1987) 2020 Sep;264:114659
Environmental pollution (Barking, Essex : 1987) 2020 Sep;264:114659
Sirtuin 3-mediated deacetylation of acyl-CoA synthetase family member 3 by protocatechuic acid attenuates non-alcoholic fatty liver disease.
Sun R, Kang X, Zhao Y, Wang Z, Wang R, Fu R, Li Y, Hu Y, Wang Z, Shan W, Zhou J, Tian X, Yao J
British journal of pharmacology 2020 Sep;177(18):4166-4180
British journal of pharmacology 2020 Sep;177(18):4166-4180
SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Body-Induced mTORC1 Inhibition.
Tomita I, Kume S, Sugahara S, Osawa N, Yamahara K, Yasuda-Yamahara M, Takeda N, Chin-Kanasaki M, Kaneko T, Mayoux E, Mark M, Yanagita M, Ogita H, Araki SI, Maegawa H
Cell metabolism 2020 Sep 1;32(3):404-419.e6
Cell metabolism 2020 Sep 1;32(3):404-419.e6
Uncovering the mechanism of Astragali Radix against nephrotic syndrome by intergrating lipidomics and network pharmacology.
Li AP, Yang L, Cui T, Zhang LC, Liu YT, Yan Y, Li K, Qin XM
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Oct;77:153274
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Oct;77:153274
Peroxisomal proliferator-activated receptor α-b deficiency induces the reprogramming of nutrient metabolism in zebrafish.
Li LY, Lv HB, Jiang ZY, Qiao F, Chen LQ, Zhang ML, Du ZY
The Journal of physiology 2020 Oct;598(20):4537-4553
The Journal of physiology 2020 Oct;598(20):4537-4553
Protective effect of Yi-Qi-Huo-Xue Decoction against ischemic heart disease by regulating cardiac lipid metabolism.
Li FH, Huang XL, Wang H, Guo SW, Li P
Chinese journal of natural medicines 2020 Oct;18(10):779-792
Chinese journal of natural medicines 2020 Oct;18(10):779-792
A substrate-trapping strategy to find E3 ubiquitin ligase substrates identifies Parkin and TRIM28 targets.
Watanabe M, Saeki Y, Takahashi H, Ohtake F, Yoshida Y, Kasuga Y, Kondo T, Yaguchi H, Suzuki M, Ishida H, Tanaka K, Hatakeyama S
Communications biology 2020 Oct 20;3(1):592
Communications biology 2020 Oct 20;3(1):592
A novel bile acid analog, A17, ameliorated non-alcoholic steatohepatitis in high-fat diet-fed hamsters.
Wang Y, Zhu Y, Niu J, Deng Q, Guo S, Jiang H, Peng Z, Xue Y, Peng H, Xuan L, Pan G
Toxicology and applied pharmacology 2020 Oct 1;404:115169
Toxicology and applied pharmacology 2020 Oct 1;404:115169
Effect and mechanism of ginsenoside Rg1-regulating hepatic steatosis in HepG2 cells induced by free fatty acid.
Gao Y, Zhang S, Li J, Zhao J, Xiao Q, Zhu Y, Zhang J, Huang W
Bioscience, biotechnology, and biochemistry 2020 Nov;84(11):2228-2240
Bioscience, biotechnology, and biochemistry 2020 Nov;84(11):2228-2240
Melanoma Persister Cells Are Tolerant to BRAF/MEK Inhibitors via ACOX1-Mediated Fatty Acid Oxidation.
Shen S, Faouzi S, Souquere S, Roy S, Routier E, Libenciuc C, André F, Pierron G, Scoazec JY, Robert C
Cell reports 2020 Nov 24;33(8):108421
Cell reports 2020 Nov 24;33(8):108421
CPT1A Over-Expression Increases Reactive Oxygen Species in the Mitochondria and Promotes Antioxidant Defenses in Prostate Cancer.
Joshi M, Kim J, D'Alessandro A, Monk E, Bruce K, Elajaili H, Nozik-Grayck E, Goodspeed A, Costello JC, Schlaepfer IR
Cancers 2020 Nov 18;12(11)
Cancers 2020 Nov 18;12(11)
RIPK3 Orchestrates Fatty Acid Metabolism in Tumor-Associated Macrophages and Hepatocarcinogenesis.
Wu L, Zhang X, Zheng L, Zhao H, Yan G, Zhang Q, Zhou Y, Lei J, Zhang J, Wang J, Xin R, Jiang L, Peng J, Chen Q, Lam SM, Shui G, Miao H, Li Y
Cancer immunology research 2020 May;8(5):710-721
Cancer immunology research 2020 May;8(5):710-721
Sirt3 modulates fatty acid oxidation and attenuates cisplatin-induced AKI in mice.
Li M, Li CM, Ye ZC, Huang J, Li Y, Lai W, Peng H, Lou TQ
Journal of cellular and molecular medicine 2020 May;24(9):5109-5121
Journal of cellular and molecular medicine 2020 May;24(9):5109-5121
Modulation of SIRT1-mediated signaling cascades in the liver contributes to the amelioration of nonalcoholic steatohepatitis in high fat fed middle-aged LDL receptor knockout mice by dihydromyricetin.
Zeng Y, Hua YQ, Wang W, Zhang H, Xu XL
Biochemical pharmacology 2020 May;175:113927
Biochemical pharmacology 2020 May;175:113927
Yin Zhi Huang, a traditional Chinese herbal formula, ameliorates diet-induced obesity and hepatic steatosis by activating the AMPK/SREBP-1 and the AMPK/ACC/CPT1A pathways.
Yao Q, Li S, Cheng X, Zou Y, Shen Y, Zhang S
Annals of translational medicine 2020 Mar;8(5):231
Annals of translational medicine 2020 Mar;8(5):231
Low Expression of Sirtuin 1 in the Dairy Cows with Mild Fatty Liver Alters Hepatic Lipid Metabolism.
Li Y, Zou S, Ding H, Hao N, Huang Y, Tang J, Cheng J, Feng S, Li J, Wang X, Wu J
Animals : an open access journal from MDPI 2020 Mar 27;10(4)
Animals : an open access journal from MDPI 2020 Mar 27;10(4)
Prohibitin 2 deficiency impairs cardiac fatty acid oxidation and causes heart failure.
Wu D, Jian C, Peng Q, Hou T, Wu K, Shang B, Zhao M, Wang Y, Zheng W, Ma Q, Li CY, Cheng H, Wang X, Zhao L
Cell death & disease 2020 Mar 12;11(3):181
Cell death & disease 2020 Mar 12;11(3):181
Severe hypoglycemia exacerbates myocardial dysfunction and metabolic remodeling in diabetic mice.
Huang L, Zhou Y, Chen Z, Zhang M, Zhan Z, Wang L, Liu L
Molecular and cellular endocrinology 2020 Mar 1;503:110692
Molecular and cellular endocrinology 2020 Mar 1;503:110692
Hepatic HuR modulates lipid homeostasis in response to high-fat diet.
Zhang Z, Zong C, Jiang M, Hu H, Cheng X, Ni J, Yi X, Jiang B, Tian F, Chang MW, Su W, Zhu L, Li J, Xiang X, Miao C, Gorospe M, de Cabo R, Dou Y, Ju Z, Yang J, Jiang C, Yang Z, Wang W
Nature communications 2020 Jun 16;11(1):3067
Nature communications 2020 Jun 16;11(1):3067
Identification of FABP5 as an immunometabolic marker in human hepatocellular carcinoma.
Liu F, Liu W, Zhou S, Yang C, Tian M, Jia G, Wang H, Zhu B, Feng M, Lu Y, Qiao T, Wang X, Cao W, Wang X, Shi Y, Wu D
Journal for immunotherapy of cancer 2020 Jul;8(2)
Journal for immunotherapy of cancer 2020 Jul;8(2)
Spexin protects cardiomyocytes from hypoxia-induced metabolic and mitochondrial dysfunction.
Liu Y, Sun L, Zheng L, Su M, Liu H, Wei Y, Li D, Wang Y, Dai C, Gong Y, Zhao C, Li Y
Naunyn-Schmiedeberg's archives of pharmacology 2020 Jan;393(1):25-33
Naunyn-Schmiedeberg's archives of pharmacology 2020 Jan;393(1):25-33
Flavonoids extracted from mulberry (Morus alba L.) leaf improve skeletal muscle mitochondrial function by activating AMPK in type 2 diabetes.
Meng Q, Qi X, Fu Y, Chen Q, Cheng P, Yu X, Sun X, Wu J, Li W, Zhang Q, Li Y, Wang A, Bian H
Journal of ethnopharmacology 2020 Feb 10;248:112326
Journal of ethnopharmacology 2020 Feb 10;248:112326
Hepatic Synaptotagmin 1 is involved in the remodelling of liver plasma- membrane lipid composition and gene expression in male Apoe-deficient mice consuming a Western diet.
Sancho-Knapik S, Pastor O, Barranquero C, Herrera Marcos LV, Guillén N, Arnal C, Gascón S, Navarro MA, Rodríguez-Yoldi MJ, Busto R, Lasunción MA, Osada J
Biochimica et biophysica acta. Molecular and cell biology of lipids 2020 Dec;1865(12):158790
Biochimica et biophysica acta. Molecular and cell biology of lipids 2020 Dec;1865(12):158790
Dynamic Cardiolipin Synthesis Is Required for CD8+ T Cell Immunity.
Corrado M, Edwards-Hicks J, Villa M, Flachsmann LJ, Sanin DE, Jacobs M, Baixauli F, Stanczak M, Anderson E, Azuma M, Quintana A, Curtis JD, Clapes T, Grzes KM, Kabat AM, Kyle R, Patterson AE, Geltink RK, Amulic B, Steward CG, Strathdee D, Trompouki E, O'Sullivan D, Pearce EJ, Pearce EL
Cell metabolism 2020 Dec 1;32(6):981-995.e7
Cell metabolism 2020 Dec 1;32(6):981-995.e7
Hypertensive Rats Treated Chronically With Nω-Nitro-L-Arginine Methyl Ester (L-NAME) Induced Disorder of Hepatic Fatty Acid Metabolism and Intestinal Pathophysiology.
Li B, He X, Lei SS, Zhou FC, Zhang NY, Chen YH, Wang YZ, Su J, Yu JJ, Li LZ, Zheng X, Luo R, Kołodyńska D, Xiong S, Lv GY, Chen SH
Frontiers in pharmacology 2019;10:1677
Frontiers in pharmacology 2019;10:1677
UPLC-QTOF/MS-based metabolomics analysis of plasma reveals an effect of Xue-Fu-Zhu-Yu capsules on blood-stasis syndrome in CHD rats.
Zhao Y, Nie S, Yi M, Wu N, Wang W, Zhang Z, Yao Y, Wang D
Journal of ethnopharmacology 2019 Sep 15;241:111908
Journal of ethnopharmacology 2019 Sep 15;241:111908
Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1.
Zhang Y, Li C, Hu C, Wu Q, Cai Y, Xing S, Lu H, Wang L, Huang, Sun L, Li T, He X, Zhong X, Wang J, Gao P, Smith ZJ, Jia W, Zhang H
EMBO reports 2019 Oct 4;20(10):e48115
EMBO reports 2019 Oct 4;20(10):e48115
The contrary intracellular and extracellular functions of PEDF in HCC development.
Li C, Huang Z, Zhu L, Yu X, Gao T, Feng J, Hong H, Yin H, Zhou T, Qi W, Yang Z, Liu C, Yang X, Gao G
Cell death & disease 2019 Oct 3;10(10):742
Cell death & disease 2019 Oct 3;10(10):742
Apple Polyphenol Extract Alleviates High-Fat-Diet-Induced Hepatic Steatosis in Male C57BL/6 Mice by Targeting LKB1/AMPK Pathway.
Li D, Liu F, Wang X, Li X
Journal of agricultural and food chemistry 2019 Nov 6;67(44):12208-12218
Journal of agricultural and food chemistry 2019 Nov 6;67(44):12208-12218
Loss of ubiquitin-conjugating enzyme E2 (Ubc9) in macrophages exacerbates multiple low-dose streptozotocin-induced diabetes by attenuating M2 macrophage polarization.
Wang F, Sun F, Luo J, Yue T, Chen L, Zhou H, Zhang J, Yang C, Luo X, Zhou Q, Zhu H, Li J, Yang P, Xiong F, Yu Q, Zhang H, Zhang W, Xu A, Zhou Z, Lu Q, Eizirik DL, Zhang S, Wang CY
Cell death & disease 2019 Nov 26;10(12):892
Cell death & disease 2019 Nov 26;10(12):892
Role of ketone signaling in the hepatic response to fasting.
Geisler CE, Ghimire S, Bogan RL, Renquist BJ
American journal of physiology. Gastrointestinal and liver physiology 2019 May 1;316(5):G623-G631
American journal of physiology. Gastrointestinal and liver physiology 2019 May 1;316(5):G623-G631
Integrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 Mutation.
Zhou L, Wang Z, Hu C, Zhang C, Kovatcheva-Datchary P, Yu D, Liu S, Ren F, Wang X, Li Y, Hou X, Piao H, Lu X, Zhang Y, Xu G
Journal of proteome research 2019 Mar 1;18(3):960-969
Journal of proteome research 2019 Mar 1;18(3):960-969
MSC-regulated lncRNA MACC1-AS1 promotes stemness and chemoresistance through fatty acid oxidation in gastric cancer.
He W, Liang B, Wang C, Li S, Zhao Y, Huang Q, Liu Z, Yao Z, Wu Q, Liao W, Zhang S, Liu Y, Xiang Y, Liu J, Shi M
Oncogene 2019 Jun;38(23):4637-4654
Oncogene 2019 Jun;38(23):4637-4654
Impairment of Fatty Acid Oxidation in Alveolar Epithelial Cells Mediates Acute Lung Injury.
Cui H, Xie N, Banerjee S, Ge J, Guo S, Liu G
American journal of respiratory cell and molecular biology 2019 Feb;60(2):167-178
American journal of respiratory cell and molecular biology 2019 Feb;60(2):167-178
Coenzyme Q10 attenuates high-fat diet-induced non-alcoholic fatty liver disease through activation of the AMPK pathway.
Chen K, Chen X, Xue H, Zhang P, Fang W, Chen X, Ling W
Food & function 2019 Feb 20;10(2):814-823
Food & function 2019 Feb 20;10(2):814-823
Fe3O4@OA@Poloxamer nanoparticles lower triglyceride in hepatocytes through liposuction effect and nano-enzyme effect.
Sun Y, Shi F, Niu Y, Zhang Y, Xiong F
Colloids and surfaces. B, Biointerfaces 2019 Dec 1;184:110528
Colloids and surfaces. B, Biointerfaces 2019 Dec 1;184:110528
Adropin reduces blood glucose levels in mice by limiting hepatic glucose production.
Thapa D, Xie B, Manning JR, Zhang M, Stoner MW, Huckestein BR, Edmunds LR, Zhang X, Dedousis NL, O'Doherty RM, Jurczak MJ, Scott I
Physiological reports 2019 Apr;7(8):e14043
Physiological reports 2019 Apr;7(8):e14043
CD36 plays a negative role in the regulation of lipophagy in hepatocytes through an AMPK-dependent pathway.
Li Y, Yang P, Zhao L, Chen Y, Zhang X, Zeng S, Wei L, Varghese Z, Moorhead JF, Chen Y, Ruan XZ
Journal of lipid research 2019 Apr;60(4):844-855
Journal of lipid research 2019 Apr;60(4):844-855
Inhibition of soluble epoxide hydrolase ameliorates hyperhomocysteinemia-induced hepatic steatosis by enhancing β-oxidation of fatty acid in mice.
Yao L, Cao B, Cheng Q, Cai W, Ye C, Liang J, Liu W, Tan L, Yan M, Li B, He J, Hwang SH, Zhang X, Wang C, Ai D, Hammock BD, Zhu Y
American journal of physiology. Gastrointestinal and liver physiology 2019 Apr 1;316(4):G527-G538
American journal of physiology. Gastrointestinal and liver physiology 2019 Apr 1;316(4):G527-G538
A novel approach to target hypoxic cancer cells via combining β-oxidation inhibitor etomoxir with radiation.
Dheeraj A, Agarwal C, Schlaepfer IR, Raben D, Singh R, Agarwal R, Deep G
Hypoxia (Auckland, N.Z.) 2018;6:23-33
Hypoxia (Auckland, N.Z.) 2018;6:23-33
GLP-1 receptor agonist ameliorates obesity-induced chronic kidney injury via restoring renal metabolism homeostasis.
Wang C, Li L, Liu S, Liao G, Li L, Chen Y, Cheng J, Lu Y, Liu J
PloS one 2018;13(3):e0193473
PloS one 2018;13(3):e0193473
Combinatorial treatment of Rhizoma Paridis saponins and sorafenib overcomes the intolerance of sorafenib.
Yao J, Man S, Dong H, Yang L, Ma L, Gao W
The Journal of steroid biochemistry and molecular biology 2018 Oct;183:159-166
The Journal of steroid biochemistry and molecular biology 2018 Oct;183:159-166
YAP1 enhances NF-κB-dependent and independent effects on clock-mediated unfolded protein responses and autophagy in sarcoma.
Rivera-Reyes A, Ye S, E Marino G, Egolf S, E Ciotti G, Chor S, Liu Y, Posimo JM, Park PMC, Pak K, Babichev Y, Sostre-Colón J, Tameire F, Leli NM, Koumenis C, C Brady D, Mancuso A, Weber K, Gladdy R, Qi J, Eisinger-Mathason TSK
Cell death & disease 2018 Oct 31;9(11):1108
Cell death & disease 2018 Oct 31;9(11):1108
Rosiglitazone ameliorates palmitic acid-induced cytotoxicity in TM4 Sertoli cells.
Ge X, Pan P, Jing J, Hu X, Chen L, Qiu X, Ma R, Jueraitetibaike K, Huang X, Yao B
Reproductive biology and endocrinology : RB&E 2018 Oct 17;16(1):98
Reproductive biology and endocrinology : RB&E 2018 Oct 17;16(1):98
The protein acetylase GCN5L1 modulates hepatic fatty acid oxidation activity via acetylation of the mitochondrial β-oxidation enzyme HADHA.
Thapa D, Wu K, Stoner MW, Xie B, Zhang M, Manning JR, Lu Z, Li JH, Chen Y, Gucek M, Playford MP, Mehta NN, Harmon D, O'Doherty RM, Jurczak MJ, Sack MN, Scott I
The Journal of biological chemistry 2018 Nov 16;293(46):17676-17684
The Journal of biological chemistry 2018 Nov 16;293(46):17676-17684
IL-25 stimulates M2 macrophage polarization and thereby promotes mitochondrial respiratory capacity and lipolysis in adipose tissues against obesity.
Feng J, Li L, Ou Z, Li Q, Gong B, Zhao Z, Qi W, Zhou T, Zhong J, Cai W, Yang X, Zhao A, Gao G, Yang Z
Cellular & molecular immunology 2018 May;15(5):493-505
Cellular & molecular immunology 2018 May;15(5):493-505
Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.
Qiao Y, Xu L, Tao X, Yin L, Qi Y, Xu Y, Han X, Tang Z, Ma X, Liu K, Peng J
Toxicology letters 2018 Mar 1;284:37-45
Toxicology letters 2018 Mar 1;284:37-45
Fibroblast growth factor 21 increases hepatic oxidative capacity but not physical activity or energy expenditure in hepatic peroxisome proliferator-activated receptor γ coactivator-1α-deficient mice.
Fletcher JA, Linden MA, Sheldon RD, Meers GM, Morris EM, Butterfield A, Perfield JW 2nd, Rector RS, Thyfault JP
Experimental physiology 2018 Mar 1;103(3):408-418
Experimental physiology 2018 Mar 1;103(3):408-418
Scutellaria baicalensis regulates FFA metabolism to ameliorate NAFLD through the AMPK-mediated SREBP signaling pathway.
Chen Q, Liu M, Yu H, Li J, Wang S, Zhang Y, Qiu F, Wang T
Journal of natural medicines 2018 Jun;72(3):655-666
Journal of natural medicines 2018 Jun;72(3):655-666
Disrupting SOD1 activity inhibits cell growth and enhances lipid accumulation in nasopharyngeal carcinoma.
Li S, Fu L, Tian T, Deng L, Li H, Xia W, Gong Q
Cell communication and signaling : CCS 2018 Jun 11;16(1):28
Cell communication and signaling : CCS 2018 Jun 11;16(1):28
Chronic low-dose exposure of nonylphenol alters energy homeostasis in the reproductive system of female rats.
Di QN, Cao WX, Xu R, Lu L, Xu Q, Wang XB
Toxicology and applied pharmacology 2018 Jun 1;348:67-75
Toxicology and applied pharmacology 2018 Jun 1;348:67-75
N-3 polyunsaturated fatty acids ameliorate hepatic steatosis via the PPAR-α/CPT-1α pathway in a mouse model of parenteral nutrition.
Tian F, Wang J, Sun H, Yang J, Wang P, Wan S, Gao X, Zhang L, Li J, Wang X
Biochemical and biophysical research communications 2018 Jul 2;501(4):974-981
Biochemical and biophysical research communications 2018 Jul 2;501(4):974-981
Polyacetylene glycoside attenuates ischemic kidney injury by co-inhibiting inflammation, mitochondria dysfunction and lipotoxicity.
Zhou Y, Du D, Liu S, Zhao M, Yuan Y, Li L, Chen Y, Lu Y, Cheng J, Liu J
Life sciences 2018 Jul 1;204:55-64
Life sciences 2018 Jul 1;204:55-64
Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity.
Cheng L, Ge M, Lan Z, Ma Z, Chi W, Kuang W, Sun K, Zhao X, Liu Y, Feng Y, Huang Y, Luo M, Li L, Zhang B, Hu X, Xu L, Liu X, Huo Y, Deng H, Yang J, Xi Q, Zhang Y, Siegenthaler JA, Chen L
Archives of toxicology 2018 Jan;92(1):469-485
Archives of toxicology 2018 Jan;92(1):469-485
PIK3R3 regulates PPARα expression to stimulate fatty acid β-oxidation and decrease hepatosteatosis.
Yang X, Fu Y, Hu F, Luo X, Hu J, Wang G
Experimental & molecular medicine 2018 Jan 19;50(1):e431
Experimental & molecular medicine 2018 Jan 19;50(1):e431
Adipose-specific lipin1 overexpression in mice protects against alcohol-induced liver injury.
Zhang W, Zhong W, Sun Q, Sun X, Zhou Z
Scientific reports 2018 Jan 11;8(1):408
Scientific reports 2018 Jan 11;8(1):408
Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis.
Kalucka J, Bierhansl L, Conchinha NV, Missiaen R, Elia I, Brüning U, Scheinok S, Treps L, Cantelmo AR, Dubois C, de Zeeuw P, Goveia J, Zecchin A, Taverna F, Morales-Rodriguez F, Brajic A, Conradi LC, Schoors S, Harjes U, Vriens K, Pilz GA, Chen R, Cubbon R, Thienpont B, Cruys B, Wong BW, Ghesquière B, Dewerchin M, De Bock K, Sagaert X, Jessberger S, Jones EAV, Gallez B, Lambrechts D, Mazzone M, Eelen G, Li X, Fendt SM, Carmeliet P
Cell metabolism 2018 Dec 4;28(6):881-894.e13
Cell metabolism 2018 Dec 4;28(6):881-894.e13
Paeoniflorin Ameliorates Fructose-Induced Insulin Resistance and Hepatic Steatosis by Activating LKB1/AMPK and AKT Pathways.
Li YC, Qiao JY, Wang BY, Bai M, Shen JD, Cheng YX
Nutrients 2018 Aug 5;10(8)
Nutrients 2018 Aug 5;10(8)
Mitochondria-targeted ubiquinone (MitoQ) enhances acetaldehyde clearance by reversing alcohol-induced posttranslational modification of aldehyde dehydrogenase 2: A molecular mechanism of protection against alcoholic liver disease.
Hao L, Sun Q, Zhong W, Zhang W, Sun X, Zhou Z
Redox biology 2018 Apr;14:626-636
Redox biology 2018 Apr;14:626-636
Fish oil feeding reverses hepatomegaly and disrupted hepatic function due to the lack of FXR signaling.
Miyata M, Shinno K, Kinoshita T, Kinoshita Y, Sugiura Y
The Journal of toxicological sciences 2017;42(6):671-681
The Journal of toxicological sciences 2017;42(6):671-681
A signature of enhanced lipid metabolism, lipid peroxidation and aldehyde stress in therapy-induced senescence.
Flor AC, Wolfgeher D, Wu D, Kron SJ
Cell death discovery 2017;3:17075
Cell death discovery 2017;3:17075
Kupffer cells activation promoted binge drinking-induced fatty liver by activating lipolysis in white adipose tissues.
Zhao YY, Yang R, Xiao M, Guan MJ, Zhao N, Zeng T
Toxicology 2017 Sep 1;390:53-60
Toxicology 2017 Sep 1;390:53-60
Attenuation of hepatic steatosis by purple sweet potato colour is associated with blocking Src/ERK/C/EBPβ signalling in high-fat-diet-treated mice.
Wang X, Zhang ZF, Zheng GH, Wang AM, Sun CH, Qin SP, Zhuang J, Lu J, Ma DF, Zheng YL
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2017 Oct;42(10):1082-1091
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2017 Oct;42(10):1082-1091
Mitochondrial Priming by CD28.
Klein Geltink RI, O'Sullivan D, Corrado M, Bremser A, Buck MD, Buescher JM, Firat E, Zhu X, Niedermann G, Caputa G, Kelly B, Warthorst U, Rensing-Ehl A, Kyle RL, Vandersarren L, Curtis JD, Patterson AE, Lawless S, Grzes K, Qiu J, Sanin DE, Kretz O, Huber TB, Janssens S, Lambrecht BN, Rambold AS, Pearce EJ, Pearce EL
Cell 2017 Oct 5;171(2):385-397.e11
Cell 2017 Oct 5;171(2):385-397.e11
p38α MAPK antagonizing JNK to control the hepatic fat accumulation in pediatric patients onset intestinal failure.
Xiao Y, Wang J, Yan W, Zhou K, Cao Y, Cai W
Cell death & disease 2017 Oct 12;8(10):e3110
Cell death & disease 2017 Oct 12;8(10):e3110
Targeted Metabolomics Reveals Abnormal Hepatic Energy Metabolism by Depletion of β-Carotene Oxygenase 2 in Mice.
Wu L, Guo X, Lyu Y, Clarke SL, Lucas EA, Smith BJ, Hildebrand D, Wang W, Medeiros DM, Shen X, Lin D
Scientific reports 2017 Nov 7;7(1):14624
Scientific reports 2017 Nov 7;7(1):14624
Xyloketal B Attenuates Fatty Acid-Induced Lipid Accumulation via the SREBP-1c Pathway in NAFLD Models.
Zhang Y, Meng T, Zuo L, Bei Y, Zhang Q, Su Z, Huang Y, Pang J, Xiang Q, Yang H
Marine drugs 2017 Jun 3;15(6)
Marine drugs 2017 Jun 3;15(6)
Aerobic capacity mediates susceptibility for the transition from steatosis to steatohepatitis.
Morris EM, McCoin CS, Allen JA, Gastecki ML, Koch LG, Britton SL, Fletcher JA, Fu X, Ding WX, Burgess SC, Rector RS, Thyfault JP
The Journal of physiology 2017 Jul 15;595(14):4909-4926
The Journal of physiology 2017 Jul 15;595(14):4909-4926
Pharmacological inhibition of NOX4 ameliorates alcohol-induced liver injury in mice through improving oxidative stress and mitochondrial function.
Sun Q, Zhang W, Zhong W, Sun X, Zhou Z
Biochimica et biophysica acta. General subjects 2017 Jan;1861(1 Pt A):2912-2921
Biochimica et biophysica acta. General subjects 2017 Jan;1861(1 Pt A):2912-2921
Calycosin attenuates triglyceride accumulation and hepatic fibrosis in murine model of non-alcoholic steatohepatitis via activating farnesoid X receptor.
Duan X, Meng Q, Wang C, Liu Z, Liu Q, Sun H, Sun P, Yang X, Huo X, Peng J, Liu K
Phytomedicine : international journal of phytotherapy and phytopharmacology 2017 Feb 15;25:83-92
Phytomedicine : international journal of phytotherapy and phytopharmacology 2017 Feb 15;25:83-92
RNA Binding Protein Ybx2 Regulates RNA Stability During Cold-Induced Brown Fat Activation.
Xu D, Xu S, Kyaw AMM, Lim YC, Chia SY, Chee Siang DT, Alvarez-Dominguez JR, Chen P, Leow MK, Sun L
Diabetes 2017 Dec;66(12):2987-3000
Diabetes 2017 Dec;66(12):2987-3000
Lipid catabolism inhibition sensitizes prostate cancer cells to antiandrogen blockade.
Flaig TW, Salzmann-Sullivan M, Su LJ, Zhang Z, Joshi M, Gijón MA, Kim J, Arcaroli JJ, Van Bokhoven A, Lucia MS, La Rosa FG, Schlaepfer IR
Oncotarget 2017 Aug 22;8(34):56051-56065
Oncotarget 2017 Aug 22;8(34):56051-56065
Hepatic overproduction of 13-HODE due to ALOX15 upregulation contributes to alcohol-induced liver injury in mice.
Zhang W, Zhong W, Sun Q, Sun X, Zhou Z
Scientific reports 2017 Aug 21;7(1):8976
Scientific reports 2017 Aug 21;7(1):8976
Medium-chain fatty acid reduces lipid accumulation by regulating expression of lipid-sensing genes in human liver cells with steatosis.
Wang B, Fu J, Li L, Gong D, Wen X, Yu P, Zeng Z
International journal of food sciences and nutrition 2016;67(3):288-97
International journal of food sciences and nutrition 2016;67(3):288-97
Dysregulation of hepatic cAMP levels via altered Pde4b expression plays a critical role in alcohol-induced steatosis.
Avila DV, Barker DF, Zhang J, McClain CJ, Barve S, Gobejishvili L
The Journal of pathology 2016 Sep;240(1):96-107
The Journal of pathology 2016 Sep;240(1):96-107
Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer.
Qian J, Chen Y, Meng T, Ma L, Meng L, Wang X, Yu T, Zask A, Shen J, Yu K
Oncotarget 2016 Oct 11;7(41):67071-67086
Oncotarget 2016 Oct 11;7(41):67071-67086
High-fat diet enhances stemness and tumorigenicity of intestinal progenitors.
Beyaz S, Mana MD, Roper J, Kedrin D, Saadatpour A, Hong SJ, Bauer-Rowe KE, Xifaras ME, Akkad A, Arias E, Pinello L, Katz Y, Shinagare S, Abu-Remaileh M, Mihaylova MM, Lamming DW, Dogum R, Guo G, Bell GW, Selig M, Nielsen GP, Gupta N, Ferrone CR, Deshpande V, Yuan GC, Orkin SH, Sabatini DM, Yilmaz ÖH
Nature 2016 Mar 3;531(7592):53-8
Nature 2016 Mar 3;531(7592):53-8
TXNIP regulates myocardial fatty acid oxidation via miR-33a signaling.
Chen J, Young ME, Chatham JC, Crossman DK, Dell'Italia LJ, Shalev A
American journal of physiology. Heart and circulatory physiology 2016 Jul 1;311(1):H64-75
American journal of physiology. Heart and circulatory physiology 2016 Jul 1;311(1):H64-75
Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice.
Niewiadomski J, Zhou JQ, Roman HB, Liu X, Hirschberger LL, Locasale JW, Stipanuk MH
Annals of the New York Academy of Sciences 2016 Jan;1363:99-115
Annals of the New York Academy of Sciences 2016 Jan;1363:99-115
HDAC4 mediates IFN-γ induced disruption of energy expenditure-related gene expression by repressing SIRT1 transcription in skeletal muscle cells.
Fang M, Fan Z, Tian W, Zhao Y, Li P, Xu H, Zhou B, Zhang L, Wu X, Xu Y
Biochimica et biophysica acta 2016 Feb;1859(2):294-305
Biochimica et biophysica acta 2016 Feb;1859(2):294-305
Foxp3 and Toll-like receptor signaling balance T(reg) cell anabolic metabolism for suppression.
Gerriets VA, Kishton RJ, Johnson MO, Cohen S, Siska PJ, Nichols AG, Warmoes MO, de Cubas AA, MacIver NJ, Locasale JW, Turka LA, Wells AD, Rathmell JC
Nature immunology 2016 Dec;17(12):1459-1466
Nature immunology 2016 Dec;17(12):1459-1466
A Novel Function of Hepatic FOG2 in Insulin Sensitivity and Lipid Metabolism Through PPARα.
Guo Y, Yu J, Deng J, Liu B, Xiao Y, Li K, Xiao F, Yuan F, Liu Y, Chen S, Guo F
Diabetes 2016 Aug;65(8):2151-63
Diabetes 2016 Aug;65(8):2151-63
Acetyl-coenzyme A carboxylase alpha promotion of glucose-mediated fatty acid synthesis enhances survival of hepatocellular carcinoma in mice and patients.
Wang MD, Wu H, Fu GB, Zhang HL, Zhou X, Tang L, Dong LW, Qin CJ, Huang S, Zhao LH, Zeng M, Wu MC, Yan HX, Wang HY
Hepatology (Baltimore, Md.) 2016 Apr;63(4):1272-86
Hepatology (Baltimore, Md.) 2016 Apr;63(4):1272-86
Diet rich in Docosahexaenoic Acid/Eicosapentaenoic Acid robustly ameliorates hepatic steatosis and insulin resistance in seipin deficient lipodystrophy mice.
Xu P, Wang H, Kayoumu A, Wang M, Huang W, Liu G
Nutrition & metabolism 2015;12:58
Nutrition & metabolism 2015;12:58
Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease.
Yan HM, Xia MF, Wang Y, Chang XX, Yao XZ, Rao SX, Zeng MS, Tu YF, Feng R, Jia WP, Liu J, Deng W, Jiang JD, Gao X
PloS one 2015;10(8):e0134172
PloS one 2015;10(8):e0134172
AMP-Activated Protein Kinase Interacts with the Peroxisome Proliferator-Activated Receptor Delta to Induce Genes Affecting Fatty Acid Oxidation in Human Macrophages.
Kemmerer M, Finkernagel F, Cavalcante MF, Abdalla DS, Müller R, Brüne B, Namgaladze D
PloS one 2015;10(6):e0130893
PloS one 2015;10(6):e0130893
Niche-dependent regulations of metabolic balance in high-fat diet-induced diabetic mice by mesenchymal stromal cells.
Ji AT, Chang YC, Fu YJ, Lee OK, Ho JH
Diabetes 2015 Mar;64(3):926-36
Diabetes 2015 Mar;64(3):926-36
Proteomics-based metabolic modeling reveals that fatty acid oxidation (FAO) controls endothelial cell (EC) permeability.
Patella F, Schug ZT, Persi E, Neilson LJ, Erami Z, Avanzato D, Maione F, Hernandez-Fernaud JR, Mackay G, Zheng L, Reid S, Frezza C, Giraudo E, Fiorio Pla A, Anderson K, Ruppin E, Gottlieb E, Zanivan S
Molecular & cellular proteomics : MCP 2015 Mar;14(3):621-34
Molecular & cellular proteomics : MCP 2015 Mar;14(3):621-34
Astrocyte Elevated Gene-1 (AEG-1) Regulates Lipid Homeostasis.
Robertson CL, Srivastava J, Siddiq A, Gredler R, Emdad L, Rajasekaran D, Akiel M, Shen XN, Corwin F, Sundaresan G, Zweit J, Croniger C, Gao X, Ghosh S, Hylemon PB, Subler MA, Windle JJ, Fisher PB, Sarkar D
The Journal of biological chemistry 2015 Jul 17;290(29):18227-18236
The Journal of biological chemistry 2015 Jul 17;290(29):18227-18236
High metastaticgastric and breast cancer cells consume oleic acid in an AMPK dependent manner.
Li S, Zhou T, Li C, Dai Z, Che D, Yao Y, Li L, Ma J, Yang X, Gao G
PloS one 2014;9(5):e97330
PloS one 2014;9(5):e97330
Fatty acid oxidation is dispensable for human macrophage IL-4-induced polarization.
Namgaladze D, Brüne B
Biochimica et biophysica acta 2014 Sep;1841(9):1329-35
Biochimica et biophysica acta 2014 Sep;1841(9):1329-35
HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression.
Huang, Li T, Li X, Zhang L, Sun L, He X, Zhong X, Jia D, Song L, Semenza GL, Gao P, Zhang H
Cell reports 2014 Sep 25;8(6):1930-1942
Cell reports 2014 Sep 25;8(6):1930-1942
A compound heterozygous mutation in GPD1 causes hepatomegaly, steatohepatitis, and hypertriglyceridemia.
Joshi M, Eagan J, Desai NK, Newton SA, Towne MC, Marinakis NS, Esteves KM, De Ferranti S, Bennett MJ, McIntyre A, Beggs AH, Berry GT, Agrawal PB
European journal of human genetics : EJHG 2014 Oct;22(10):1229-32
European journal of human genetics : EJHG 2014 Oct;22(10):1229-32
Inhibition of macrophage fatty acid β-oxidation exacerbates palmitate-induced inflammatory and endoplasmic reticulum stress responses.
Namgaladze D, Lips S, Leiker TJ, Murphy RC, Ekroos K, Ferreiros N, Geisslinger G, Brüne B
Diabetologia 2014 May;57(5):1067-77
Diabetologia 2014 May;57(5):1067-77
Identification of 5' AMP-activated kinase as a target of reactive aldehydes during chronic ingestion of high concentrations of ethanol.
Shearn CT, Backos DS, Orlicky DJ, Smathers-McCullough RL, Petersen DR
The Journal of biological chemistry 2014 May 30;289(22):15449-62
The Journal of biological chemistry 2014 May 30;289(22):15449-62
SIRT1 activation by methylene blue, a repurposed drug, leads to AMPK-mediated inhibition of steatosis and steatohepatitis.
Shin SY, Kim TH, Wu H, Choi YH, Kim SG
European journal of pharmacology 2014 Mar 15;727:115-24
European journal of pharmacology 2014 Mar 15;727:115-24
KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance.
Jung DY, Chalasani U, Pan N, Friedline RH, Prosdocimo DA, Nam M, Azuma Y, Maganti R, Yu K, Velagapudi A, O'Sullivan-Murphy B, Sartoretto JL, Jain MK, Cooper MP, Urano F, Kim JK, Gray S
PloS one 2013;8(10):e77851
PloS one 2013;8(10):e77851
Chinese medicine formula lingguizhugan decoction improves Beta-oxidation and metabolism of Fatty Acid in high-fat-diet-induced rat model of Fatty liver disease.
Liu T, Yang LL, Zou L, Li DF, Wen HZ, Zheng PY, Xing LJ, Song HY, Tang XD, Ji G
Evidence-based complementary and alternative medicine : eCAM 2013;2013:429738
Evidence-based complementary and alternative medicine : eCAM 2013;2013:429738
Binge ethanol-induced HDAC3 down-regulates Cpt1α expression leading to hepatic steatosis and injury.
Kirpich I, Zhang J, Gobejishvili L, Kharebava G, Barker D, Ghare S, Joshi-Barve S, McClain CJ, Barve S
Alcoholism, clinical and experimental research 2013 Nov;37(11):1920-9
Alcoholism, clinical and experimental research 2013 Nov;37(11):1920-9
Anti-miR-33 therapy does not alter the progression of atherosclerosis in low-density lipoprotein receptor-deficient mice.
Marquart TJ, Wu J, Lusis AJ, Baldán Á
Arteriosclerosis, thrombosis, and vascular biology 2013 Mar;33(3):455-8
Arteriosclerosis, thrombosis, and vascular biology 2013 Mar;33(3):455-8
An iTRAQ proteomic study reveals an association between diet-induced enhanced fatty acid metabolism and the development of glucose intolerance in prediabetic mice.
Ho JH, Lee OK, Fu YJ, Shih HT, Tseng CY, Chung CC, Han CL, Chen YJ
Journal of proteome research 2013 Mar 1;12(3):1120-33
Journal of proteome research 2013 Mar 1;12(3):1120-33
Role of sirtuin 1 in the regulation of hepatic gene expression by thyroid hormone.
Thakran S, Sharma P, Attia RR, Hori RT, Deng X, Elam MB, Park EA
The Journal of biological chemistry 2013 Jan 11;288(2):807-18
The Journal of biological chemistry 2013 Jan 11;288(2):807-18
SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.
Zanivan S, Maione F, Hein MY, Hernández-Fernaud JR, Ostasiewicz P, Giraudo E, Mann M
Molecular & cellular proteomics : MCP 2013 Dec;12(12):3599-611
Molecular & cellular proteomics : MCP 2013 Dec;12(12):3599-611
An active metabolite of oltipraz (M2) increases mitochondrial fuel oxidation and inhibits lipogenesis in the liver by dually activating AMPK.
Kim TH, Eom JS, Lee CG, Yang YM, Lee YS, Kim SG
British journal of pharmacology 2013 Apr;168(7):1647-61
British journal of pharmacology 2013 Apr;168(7):1647-61
Binge alcohol-induced microvesicular liver steatosis and injury are associated with down-regulation of hepatic Hdac 1, 7, 9, 10, 11 and up-regulation of Hdac 3.
Kirpich I, Ghare S, Zhang J, Gobejishvili L, Kharebava G, Barve SJ, Barker D, Moghe A, McClain CJ, Barve S
Alcoholism, clinical and experimental research 2012 Sep;36(9):1578-86
Alcoholism, clinical and experimental research 2012 Sep;36(9):1578-86
Genomic alterations with impact on survival in esophageal squamous cell carcinoma identified by array comparative genomic hybridization.
Shi ZZ, Liang JW, Zhan T, Wang BS, Lin DC, Liu SG, Hao JJ, Yang H, Zhang Y, Zhan QM, Zhang KT, Wang MR
Genes, chromosomes & cancer 2011 Jul;50(7):518-26
Genes, chromosomes & cancer 2011 Jul;50(7):518-26
Establishing a relationship between prolactin and altered fatty acid β-oxidation via carnitine palmitoyl transferase 1 in breast cancer cells.
Linher-Melville K, Zantinge S, Sanli T, Gerstein H, Tsakiridis T, Singh G
BMC cancer 2011 Feb 4;11:56
BMC cancer 2011 Feb 4;11:56
Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation.
Gerin I, Clerbaux LA, Haumont O, Lanthier N, Das AK, Burant CF, Leclercq IA, MacDougald OA, Bommer GT
The Journal of biological chemistry 2010 Oct 29;285(44):33652-61
The Journal of biological chemistry 2010 Oct 29;285(44):33652-61
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 15184-1-AP(CPT1A antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using CPT1A antibody 15184-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-CPT1A (IP:15184-1-AP, 3ug; Detection:15184-1-AP 1:300) with HepG2 cells lysate 2000ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 15184-1-AP(CPT1A antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 15184-1-AP(CPT1A antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue