17526-1-AP

antibody from Proteintech Group

Targeting: ACADL ACAD4, LCAD

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

17526-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#17526-1-AP, RRID:AB_2219661

Product name

ACADL-Specific antibody

Antibody type

Polyclonal

Description

KD/KO validated ACADL-Specific antibody (Cat. #17526-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Artemether regulates liver glycogen and lipid utilization through mitochondrial pyruvate oxidation in db/db mice.

Weng W, Shen L, Yu X, Yuan R, Shao M, Han P, Sun H
American journal of translational research 2024;16(1):27-38

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Aldehyde dehydrogenase 2 serves as a key cardiometabolic adaptation regulator in response to plateau hypoxia in mice.

Gao R, Yang K, Le S, Chen H, Sun X, Dong Z, Gao P, Wang X, Shi J, Qu Y, Wei X, Hu K, Wang J, Jin L, Li Y, Ge J, Sun A
Translational research : the journal of laboratory and clinical medicine 2024 May;267:25-38

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Induction of Fatty Acid Oxidation Underlies DNA Damage-Induced Cell Death and Ameliorates Obesity-Driven Chemoresistance.

Hwang S, Yang S, Park K, Kim B, Kim M, Shin S, Yoo A, Ahn J, Jang J, Yim YS, Seong RH, Jeong SM
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(10):e2304702

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miR-1268a Regulates Fatty Acid Metabolism by Targeting CD36 in Angiotensin II-induced Heart Failure.

Xu G, Xu Y, Zhang Y, Kao G, Li J
Cell biochemistry and biophysics 2024 Jun;82(2):1193-1201

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The characterization of protein lactylation in relation to cardiac metabolic reprogramming in neonatal mouse hearts.

Zhang T, Zhu Y, Wang X, Chong D, Wang H, Bu D, Zhao M, Fang L, Li C
Journal of genetics and genomics = Yi chuan xue bao 2024 Jul;51(7):735-748

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Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation.

Mao Y, Zhang J, Zhou Q, He X, Zheng Z, Wei Y, Zhou K, Lin Y, Yu H, Zhang H, Zhou Y, Lin P, Wu B, Yuan Y, Zhao J, Xu W, Zhao S
Cell research 2024 Jan;34(1):13-30

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Comparison of the stage-dependent mitochondrial changes in response to pressure overload between the diseased right and left ventricle in the rat.

Li L, Niemann B, Knapp F, Werner S, Mühlfeld C, Schneider JP, Jurida LM, Molenda N, Schmitz ML, Yin X, Mayr M, Schulz R, Kracht M, Rohrbach S
Basic research in cardiology 2024 Aug;119(4):587-611

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Shen-Shuai-II-Recipe inhibits tubular inflammation by PPARα-mediated fatty acid oxidation to attenuate fibroblast activation in fibrotic kidneys.

Wang M, Wang L, Zhou L, Xu Y, Wang C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155450

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Moderate replacement of fish oil with palmitic acid-stimulated mitochondrial fusion promotes β-oxidation by Mfn2 interacting with Cpt1α via its GTPase-domain.

Song YF, Wang LJ, Luo Z, Hogstrand C, Lai XH, Zheng FF
The Journal of nutritional biochemistry 2024 Apr;126:109559

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Bulk and single-cell transcriptome profiling reveal extracellular matrix mechanical regulation of lipid metabolism reprograming through YAP/TEAD4/ACADL axis in hepatocellular carcinoma.

Cai J, Chen T, Jiang Z, Yan J, Ye Z, Ruan Y, Tao L, Shen Z, Liang X, Wang Y, Xu J, Cai X
International journal of biological sciences 2023;19(7):2114-2131

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Metabolic characteristics of voriconazole - Induced liver injury in rats.

Du Q, Teng M, Yang L, Meng C, Qiu Y, Wang C, Chen J, Wang T, Chen S, Luo Y, Sun J, Dong Y
Chemico-biological interactions 2023 Sep 25;383:110693

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NQO1/CPT1A promotes the progression of pancreatic adenocarcinoma via fatty acid oxidation.

Xu R, Liu Y, Ma L, Sun Y, Liu H, Yang Y, Jin T, Yang D
Acta biochimica et biophysica Sinica 2023 May 29;55(5):758-768

---

ACADL suppresses PD-L1 expression to prevent cancer immune evasion by targeting Hippo/YAP signaling in lung adenocarcinoma.

Li L, Wang LL, Wang TL, Zheng FM
Medical oncology (Northwood, London, England) 2023 Mar 17;40(4):118

---

Suppression of fatty acid oxidation supports pancreatic cancer growth and survival under hypoxic conditions through autophagy induction.

Kim B, Gwak J, Kim M, Yang S, Hwang S, Shin S, Kim JH, Son J, Jeong SM
Cancer gene therapy 2023 Jun;30(6):878-889

---

Klf4-Sirt3/Pparα-Lcad pathway contributes to high phosphate-induced lipid degradation.

Yu A, Xu Y, Hogstrand C, Zhao T, Tan XY, Wei X, Song YF, Luo Z
Cell communication and signaling : CCS 2023 Jan 9;21(1):5

---

Maturation of lipid metabolism in the fetal and newborn sheep heart.

Drake RR, Louey S, Thornburg KL
American journal of physiology. Regulatory, integrative and comparative physiology 2023 Dec 1;325(6):R809-R819

---

Novel treatment and insight for irradiation-induced injuries: Dibucaine ameliorates irradiation-induced testicular injury by inhibiting fatty acid oxidation in primary Leydig cells.

Ran L, Chen Q, Lu X, Gao Z, Cui F, Liu X, Xue B
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114903

---

G-protein coupled receptor 19 (GPR19) knockout mice display sex-dependent metabolic dysfunction.

Mushala BAS, Xie B, Sipula IJ, Stoner MW, Thapa D, Manning JR, Bugga P, Vandevender AM, Jurczak MJ, Scott I
Scientific reports 2023 Apr 15;13(1):6134

---

ACADL Functions as a Tumor Suppressor in Hepatocellular Carcinoma Metastasis by Inhibiting Matrix Metalloproteinase 14.

Guo D, Zhang X, Cui H, Yu D, Zhang H, Shi X, Pang C, Li J, Guo W, Zhang S
Frontiers in oncology 2022;12:821484

---

ZLN005 Alleviates In Vivo and In Vitro Renal Fibrosis via PGC-1α-Mediated Mitochondrial Homeostasis.

Zhu P, Ma H, Cui S, Zhou X, Xu W, Yu J, Li J
Pharmaceuticals (Basel, Switzerland) 2022 Mar 31;15(4)

---

Nicotinamide Mononucleotide Administration Restores Redox Homeostasis via the Sirt3-Nrf2 Axis and Protects Aged Mice from Oxidative Stress-Induced Liver Injury.

Luo C, Ding W, Yang C, Zhang W, Liu X, Deng H
Journal of proteome research 2022 Jul 1;21(7):1759-1770

---

Intrauterine growth restriction elevates circulating acylcarnitines and suppresses fatty acid metabolism genes in the fetal sheep heart.

Drake RR, Louey S, Thornburg KL
The Journal of physiology 2022 Feb;600(3):655-670

---

Cysteine-Rich LIM-Only Protein 4 (CRP4) Promotes Atherogenesis in the ApoE(-/-) Mouse Model.

Längst N, Adler J, Kuret A, Peter A, Ruth P, Boldt K, Lukowski R
Cells 2022 Apr 17;11(8)

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The Protective Effect of 1,25(OH)(2)D(3) on Myocardial Function is Mediated via Sirtuin 3-Regulated Fatty Acid Metabolism.

Yang J, Zhang Y, Pan Y, Sun C, Liu Z, Liu N, Fu Y, Li X, Li Y, Kong J
Frontiers in cell and developmental biology 2021;9:627135

---

Fatty Acids Inhibit LAMP2-Mediated Autophagy Flux via Activating ER Stress Pathway in Alcohol-Related Liver Disease.

Guo W, Zhong W, Hao L, Dong H, Sun X, Yue R, Li T, Zhou Z
Cellular and molecular gastroenterology and hepatology 2021;12(5):1599-1615

---

Multi-Omics Analysis of Fatty Acid Metabolism in Thyroid Carcinoma.

Lu J, Zhang Y, Sun M, Ding C, Zhang L, Kong Y, Cai M, Miccoli P, Ma C, Yue X
Frontiers in oncology 2021;11:737127

---

Simultaneously targeting SOAT1 and CPT1A ameliorates hepatocellular carcinoma by disrupting lipid homeostasis.

Ren M, Xu H, Xia H, Tang Q, Bi F
Cell death discovery 2021 May 29;7(1):125

---

NAD(+) Repletion Reverses Heart Failure With Preserved Ejection Fraction.

Tong D, Schiattarella GG, Jiang N, Altamirano F, Szweda PA, Elnwasany A, Lee DI, Yoo H, Kass DA, Szweda LI, Lavandero S, Verdin E, Gillette TG, Hill JA
Circulation research 2021 May 28;128(11):1629-1641

---

The role of SAMM50 in non-alcoholic fatty liver disease: from genetics to mechanisms.

Li Z, Shen W, Wu G, Qin C, Zhang Y, Wang Y, Song G, Xiao C, Zhang X, Deng G, Wang R, Wang X
FEBS open bio 2021 Jul;11(7):1893-1906

---

Nanoparticle-Mediated Lipid Metabolic Reprogramming of T Cells in Tumor Microenvironments for Immunometabolic Therapy.

Kim D, Wu Y, Li Q, Oh YK
Nano-micro letters 2021 Jan 4;13(1):31

---

The Mitochondrial Antioxidant Sirtuin3 Cooperates with Lipid Metabolism to Safeguard Neurogenesis in Aging and Depression.

Santos SS, Moreira JB, Costa M, Rodrigues RS, Sebastião AM, Xapelli S, Solá S
Cells 2021 Dec 29;11(1)

---

Reprogramming of Lipid Metabolism as a New Driving Force Behind Tauroursodeoxycholic Acid-Induced Neural Stem Cell Proliferation.

Fernandes MB, Costa M, Ribeiro MF, Siquenique S, Sá Santos S, Martins J, Coelho AV, Silva MFB, Rodrigues CMP, Solá S
Frontiers in cell and developmental biology 2020;8:335

---

Immunoprecipitation of Acetyl-lysine And Western Blotting of Long-chain acyl-CoA Dehydrogenases and Beta-hydroxyacyl-CoA Dehydrogenase in Palmitic Acid Treated Human Renal Tubular Epithelial Cells.

Lv T, Zhu S, Ma Y, Feng H, Wan Q
Bio-protocol 2020 Sep 20;10(18):e3765

---

Slc22a5 haploinsufficiency does not aggravate the phenotype of the long-chain acyl-CoA dehydrogenase KO mouse.

Ranea-Robles P, Yu C, van Vlies N, Vaz FM, Houten SM
Journal of inherited metabolic disease 2020 May;43(3):486-495

---

Functional changes of the liver in the absence of growth hormone (GH) action - Proteomic and metabolomic insights from a GH receptor deficient pig model.

Riedel EO, Hinrichs A, Kemter E, Dahlhoff M, Backman M, Rathkolb B, Prehn C, Adamski J, Renner S, Blutke A, de Angelis MH, Bidlingmaier M, Schopohl J, Arnold GJ, Fröhlich T, Wolf E
Molecular metabolism 2020 Jun;36:100978

---

Increased fatty acid oxidation enzyme activity in the hearts of mice fed a high fat diet does not correlate with improved cardiac contractile function.

Thapa D, Manning JR, Mushala BAS, Stoner MW, Zhang M, Scott I
Current research in physiology 2020 Dec;3:44-49

---

GCN5L1 controls renal lipotoxicity through regulating acetylation of fatty acid oxidation enzymes.

Lv T, Hu Y, Ma Y, Zhen J, Xin W, Wan Q
Journal of physiology and biochemistry 2019 Nov;75(4):597-606

---

Berberine alleviates nonalcoholic fatty liver induced by a high-fat diet in mice by activating SIRT3.

Xu X, Zhu XP, Bai JY, Xia P, Li Y, Lu Y, Li XY, Gao X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jun;33(6):7289-7300

---

The protein acetylase GCN5L1 modulates hepatic fatty acid oxidation activity via acetylation of the mitochondrial β-oxidation enzyme HADHA.

Thapa D, Wu K, Stoner MW, Xie B, Zhang M, Manning JR, Lu Z, Li JH, Chen Y, Gucek M, Playford MP, Mehta NN, Harmon D, O'Doherty RM, Jurczak MJ, Sack MN, Scott I
The Journal of biological chemistry 2018 Nov 16;293(46):17676-17684

---

Adipose-specific lipin1 overexpression in mice protects against alcohol-induced liver injury.

Zhang W, Zhong W, Sun Q, Sun X, Zhou Z
Scientific reports 2018 Jan 11;8(1):408

---

Exogenous H(2)S switches cardiac energy substrate metabolism by regulating SIRT3 expression in db/db mice.

Sun Y, Tian Z, Liu N, Zhang L, Gao Z, Sun X, Yu M, Wu J, Yang F, Zhao Y, Ren H, Chen H, Zhao D, Wang Y, Dong S, Xu C, Lu F, Zhang W
Journal of molecular medicine (Berlin, Germany) 2018 Apr;96(3-4):281-299

---

Pivotal Role of O-GlcNAc Modification in Cold-Induced Thermogenesis by Brown Adipose Tissue Through Mitochondrial Biogenesis.

Ohashi N, Morino K, Ida S, Sekine O, Lemecha M, Kume S, Park SY, Choi CS, Ugi S, Maegawa H
Diabetes 2017 Sep;66(9):2351-2362

---

Targeted Metabolomics Reveals Abnormal Hepatic Energy Metabolism by Depletion of β-Carotene Oxygenase 2 in Mice.

Wu L, Guo X, Lyu Y, Clarke SL, Lucas EA, Smith BJ, Hildebrand D, Wang W, Medeiros DM, Shen X, Lin D
Scientific reports 2017 Nov 7;7(1):14624

---

Identification of SPOP related metabolic pathways in prostate cancer.

Yan M, Qi H, Li J, Ye G, Shao Y, Li T, Liu J, Piao HL, Xu G
Oncotarget 2017 Nov 28;8(61):103032-103046

---

Hepatic overproduction of 13-HODE due to ALOX15 upregulation contributes to alcohol-induced liver injury in mice.

Zhang W, Zhong W, Sun Q, Sun X, Zhou Z
Scientific reports 2017 Aug 21;7(1):8976

---

Acetylation of mitochondrial proteins by GCN5L1 promotes enhanced fatty acid oxidation in the heart.

Thapa D, Zhang M, Manning JR, Guimarães DA, Stoner MW, O'Doherty RM, Shiva S, Scott I
American journal of physiology. Heart and circulatory physiology 2017 Aug 1;313(2):H265-H274

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HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression.

Huang D, Li T, Li X, Zhang L, Sun L, He X, Zhong X, Jia D, Song L, Semenza GL, Gao P, Zhang H
Cell reports 2014 Sep 25;8(6):1930-1942

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Enzogenol improves diabetes-related metabolic change in C57BL/KsJ-db/db mice, a model of type 2 diabetes mellitus.

Bang CY, Choung SY
The Journal of pharmacy and pharmacology 2014 Jun;66(6):875-85

---

Diet-sensitive sources of reactive oxygen species in liver mitochondria: role of very long chain acyl-CoA dehydrogenases.

Cardoso AR, Kakimoto PA, Kowaltowski AJ
PloS one 2013;8(10):e77088

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

mouse kidney tissue were subjected to SDS PAGE followed by western blot with 17526-1-AP(ACADL-Specific antibody) at dilution of 1:300

Sample type

tissue

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The ACADL-Specific antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human ACADL-Specific. This antibody recognizes human,mouse,rat antigen. The ACADL-Specific antibody has been validated for the following applications: ELISA, WB, IHC analysis.

Appendix

17526-1-AP.pdf

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