55210-1-AP

antibody from Proteintech Group

Targeting: ACADM ACAD1, MCAD, MCADH

Provider product page for 55210-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [44]
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Validations
Western blot [1]

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Product number: 55210-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#55210-1-AP, RRID:AB_10837361
Product name: ACADM antibody
Antibody type: Polyclonal
Description: KD/KO validated ACADM antibody (Cat. #55210-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ACADM protein structure - 55210-1-AP shown in red.

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Artemether regulates liver glycogen and lipid utilization through mitochondrial pyruvate oxidation in db/db mice.

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American journal of translational research 2024;16(1):27-38

Gestational supplementation of Bifidobacterium, Lactobacillus, and Streptococcus thermophilus attenuates hepatic steatosis in offspring mice through promoting fatty acid β-oxidation.

Chen H, Wu Q, Chen X, Yu X, Zhao H, Huang Q, Huang Y, Wang J, Huang X, Wei J, Wu F, Xiao X, Wang L
Journal of food science 2024 May;89(5):3064-3077

Aldehyde dehydrogenase 2 serves as a key cardiometabolic adaptation regulator in response to plateau hypoxia in mice.

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Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation.

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Cell research 2024 Jan;34(1):13-30

Acyl-CoA dehydrogenase substrate promiscuity: Challenges and opportunities for development of substrate reduction therapy in disorders of valine and isoleucine metabolism.

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Metabolic characteristics of voriconazole - Induced liver injury in rats.

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NQO1/CPT1A promotes the progression of pancreatic adenocarcinoma via fatty acid oxidation.

Xu R, Liu Y, Ma L, Sun Y, Liu H, Yang Y, Jin T, Yang D
Acta biochimica et biophysica Sinica 2023 May 29;55(5):758-768

Dedifferentiated fat cells administration ameliorates abnormal expressions of fatty acids metabolism-related protein expressions and intestinal tissue damage in experimental necrotizing enterocolitis.

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Ginsenoside Rb1 promotes the activation of PPARα pathway via inhibiting FADD to ameliorate heart failure.

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European journal of pharmacology 2023 May 15;947:175676

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Heliyon 2023 Jul;9(7):e17891

LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease.

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EMBO molecular medicine 2023 Feb 8;15(2):e16581

A HIF-1α inhibitor combined with palmitic acid and L-carnitine treatment can prevent the fat metabolic reprogramming under hypoxia and induce apoptosis in hepatocellular carcinoma cells.

Matsufuji S, Kitajima Y, Higure K, Kimura N, Maeda S, Yamada K, Ito K, Tanaka T, Kai K, Noshiro H
Cancer & metabolism 2023 Dec 8;11(1):25

Miya Improves Osteoarthritis Characteristics via the Gut-Muscle-Joint Axis According to Multi-Omics Analyses.

Xu T, Yang D, Liu K, Gao Q, Liu Z, Li G
Frontiers in pharmacology 2022;13:816891

Fenofibrate suppresses corneal neovascularization by regulating lipid metabolism through PPARα signaling pathway.

Zhou T, Yan K, Zhang Y, Zhu L, Liao Y, Zheng X, Chen Y, Li X, Liu Z, Zhang Z
Frontiers in pharmacology 2022;13:1000254

Limonin stabilises sirtuin 6 (SIRT6) by activating ubiquitin specific peptidase 10 (USP10) in cardiac hypertrophy.

Liu LB, Huang SH, Qiu HL, Cen XF, Guo YY, Li D, Ma YL, Xu M, Tang QZ
British journal of pharmacology 2022 Sep;179(18):4516-4533

ZLN005 Alleviates In Vivo and In Vitro Renal Fibrosis via PGC-1α-Mediated Mitochondrial Homeostasis.

Zhu P, Ma H, Cui S, Zhou X, Xu W, Yu J, Li J
Pharmaceuticals (Basel, Switzerland) 2022 Mar 31;15(4)

Hif-2α regulates lipid metabolism in alcoholic fatty liver disease through mitophagy.

Wu MF, Zhang GD, Liu TT, Shen JH, Cheng JL, Shen J, Yang TY, Huang C, Zhang L
Cell & bioscience 2022 Dec 7;12(1):198

Ameliorative Effect of Ethanolic Echinacea purpurea against Hyperthyroidism-Induced Oxidative Stress via AMRK and PPAR Signal Pathway Using Transcriptomics and Network Pharmacology Analysis.

Zhu Y, Zhang J, Wang C, Zheng T, Di S, Wang Y, Fei W, Liang W, Wang L
International journal of molecular sciences 2022 Dec 22;24(1)

Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction.

Rome FI, Hughey CC
Molecular metabolism 2022 Apr;58:101452

Peroxisomal L-bifunctional protein (EHHADH) deficiency causes male-specific kidney hypertrophy and proximal tubular injury in mice.

Ranea-Robles P, Portman K, Bender A, Lee K, He JC, Mulholland DJ, Argmann C, Houten SM
Kidney360 2021 Sep;2(9):1441-1454

The peroxisomal transporter ABCD3 plays a major role in hepatic dicarboxylic fatty acid metabolism and lipid homeostasis.

Ranea-Robles P, Chen H, Stauffer B, Yu C, Bhattacharya D, Friedman SL, Puchowicz M, Houten SM
Journal of inherited metabolic disease 2021 Nov;44(6):1419-1433

Simultaneously targeting SOAT1 and CPT1A ameliorates hepatocellular carcinoma by disrupting lipid homeostasis.

Ren M, Xu H, Xia H, Tang Q, Bi F
Cell death discovery 2021 May 29;7(1):125

NAD(+) Repletion Reverses Heart Failure With Preserved Ejection Fraction.

Tong D, Schiattarella GG, Jiang N, Altamirano F, Szweda PA, Elnwasany A, Lee DI, Yoo H, Kass DA, Szweda LI, Lavandero S, Verdin E, Gillette TG, Hill JA
Circulation research 2021 May 28;128(11):1629-1641

Nanoparticle-Mediated Lipid Metabolic Reprogramming of T Cells in Tumor Microenvironments for Immunometabolic Therapy.

Kim D, Wu Y, Li Q, Oh YK
Nano-micro letters 2021 Jan 4;13(1):31

Acetyl-CoA production by specific metabolites promotes cardiac repair after myocardial infarction via histone acetylation.

Lei I, Tian S, Gao W, Liu L, Guo Y, Tang P, Chen E, Wang Z
eLife 2021 Dec 23;10

High-Dose Dexamethasone Manipulates the Tumor Microenvironment and Internal Metabolic Pathways in Anti-Tumor Progression.

Xu L, Xia H, Ni D, Hu Y, Liu J, Qin Y, Zhou Q, Yi Q, Xie Y
International journal of molecular sciences 2020 Mar 7;21(5)

Severe hypoglycemia exacerbates myocardial dysfunction and metabolic remodeling in diabetic mice.

Huang L, Zhou Y, Chen Z, Zhang M, Zhan Z, Wang L, Liu L
Molecular and cellular endocrinology 2020 Mar 1;503:110692

Impact of discontinuation of fish oil after pioglitazone-fish oil combination therapy in diabetic KK mice.

Iizuka Y, Chiba K, Kim H, Hirako S, Wada M, Matsumoto A
The Journal of nutritional biochemistry 2020 Feb;76:108265

BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma.

Li JT, Yin M, Wang D, Wang J, Lei MZ, Zhang Y, Liu Y, Zhang L, Zou SW, Hu LP, Zhang ZG, Wang YP, Wen WY, Lu HJ, Chen ZJ, Su D, Lei QY
Nature cell biology 2020 Feb;22(2):167-174

Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1.

Zhang Y, Li C, Hu C, Wu Q, Cai Y, Xing S, Lu H, Wang L, Huang D, Sun L, Li T, He X, Zhong X, Wang J, Gao P, Smith ZJ, Jia W, Zhang H
EMBO reports 2019 Oct 4;20(10):e48115

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Cell death & disease 2019 Oct 3;10(10):742

New Self-assembled Supramolecular Bowls as Potent Anticancer Agents for Human Hepatocellular Carcinoma.

Song HS, Song YH, Singh N, Kim H, Jeon H, Kim I, Kang SC, Chi KW
Scientific reports 2019 Jan 18;9(1):242

Correction: Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.

Dong D, Qi Y, Xu L, Yin L, Xu Y, Han X, Zhao Y, Peng J
Food & function 2019 Aug 1;10(8):5240-5241

Inhibition of soluble epoxide hydrolase ameliorates hyperhomocysteinemia-induced hepatic steatosis by enhancing β-oxidation of fatty acid in mice.

Yao L, Cao B, Cheng Q, Cai W, Ye C, Liang J, Liu W, Tan L, Yan M, Li B, He J, Hwang SH, Zhang X, Wang C, Ai D, Hammock BD, Zhu Y
American journal of physiology. Gastrointestinal and liver physiology 2019 Apr 1;316(4):G527-G538

Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha.

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Molecular metabolism 2018 Jan;7:80-89

PIK3R3 regulates PPARα expression to stimulate fatty acid β-oxidation and decrease hepatosteatosis.

Yang X, Fu Y, Hu F, Luo X, Hu J, Wang G
Experimental & molecular medicine 2018 Jan 19;50(1):e431

Isoquercitrin Attenuated Cardiac Dysfunction Via AMPKα-Dependent Pathways in LPS-Treated Mice.

Huang SH, Xu M, Wu HM, Wan CX, Wang HB, Wu QQ, Liao HH, Deng W, Tang QZ
Molecular nutrition & food research 2018 Dec;62(24):e1800955

HDAC4 mediates IFN-γ induced disruption of energy expenditure-related gene expression by repressing SIRT1 transcription in skeletal muscle cells.

Fang M, Fan Z, Tian W, Zhao Y, Li P, Xu H, Zhou B, Zhang L, Wu X, Xu Y
Biochimica et biophysica acta 2016 Feb;1859(2):294-305

Potent effects of dioscin against obesity in mice.

Liu M, Xu L, Yin L, Qi Y, Xu Y, Han X, Zhao Y, Sun H, Yao J, Lin Y, Liu K, Peng J
Scientific reports 2015 Jan 22;5:7973

High metastaticgastric and breast cancer cells consume oleic acid in an AMPK dependent manner.

Li S, Zhou T, Li C, Dai Z, Che D, Yao Y, Li L, Ma J, Yang X, Gao G
PloS one 2014;9(5):e97330

HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression.

Huang D, Li T, Li X, Zhang L, Sun L, He X, Zhong X, Jia D, Song L, Semenza GL, Gao P, Zhang H
Cell reports 2014 Sep 25;8(6):1930-1942

Protective effects of dioscin against alcohol-induced liver injury.

Xu T, Zheng L, Xu L, Yin L, Qi Y, Xu Y, Han X, Peng J
Archives of toxicology 2014 Mar;88(3):739-53

Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.

Dong D, Qi Y, Xu L, Yin L, Xu Y, Han X, Zhao Y, Peng J
Food & function 2014 Dec;5(12):3065-3075

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The ACADM antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human ACADM. This antibody recognizes human,mouse,rat antigen. The ACADM antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 55210-1-AP.pdf

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