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Learn14506-1-AP
antibody from Proteintech Group
Targeting: NR1D1
ear-1, hRev, Rev-ErbAalpha, REVERBA, REVERBalpha, THRA1, THRAL
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [27]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
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- Product number
- 14506-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14506-1-AP, RRID:AB_11182604
- Product name
- NR1D1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated NR1D1 antibody (Cat. #14506-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Long non-coding RNA LncCplx2 regulates glucose homeostasis and pancreatic β cell function.
Deciphering the diurnal rhythm regulating mechanism of flavin-containing monooxygenase 3 in mouse liver.
REV-ERBα negatively regulates NLRP6 transcription and reduces the severity of Salmonella infection in mice.
Mitophagy Regulates the Circadian Rhythms by Degrading NR1D1 in Simulated Microgravity and Isolation Environments.
Melatonin alleviates depression-like behaviors and cognitive dysfunction in mice by regulating the circadian rhythm of AQP4 polarization.
LncRNA Nron deficiency protects mice from diet-induced adiposity and hepatic steatosis.
Regulation of BCRP expression and sulfasalazine pharmacokinetics by the nuclear receptor REV-ERBα.
m(6)A methylation-induced NR1D1 ablation disrupts the HSC circadian clock and promotes hepatic fibrosis.
Alleviation of Limosilactobacillus reuteri in polycystic ovary syndrome protects against circadian dysrhythmia-induced dyslipidemia via capric acid and GALR1 signaling.
Jujuboside A ameliorates cognitive deficiency in delirium through promoting hippocampal E4BP4 in mice.
NR1D1 deficiency in the tumor microenvironment promotes lung tumor development by activating the NLRP3 inflammasome.
Molecular components of the circadian clock regulate HIV-1 replication.
Fluoxetine Decreases Phagocytic Function via REV-ERBα in Microglia.
BMAL1 regulates Propionibacterium acnes-induced skin inflammation via REV-ERBα in mice.
PPAR-γ integrates obesity and adipocyte clock through epigenetic regulation of Bmal1.
The actin cytoskeleton-MRTF/SRF cascade transduces cellular physical niche cues to entrain the circadian clock.
The nuclear receptor REV-ERBα regulates CYP2E1 expression and acetaminophen hepatotoxicity.
The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson's disease via the microglial NLRP3 inflammasome.
Dark-light cycle disrupts bone metabolism and suppresses joint deterioration in osteoarthritic rats.
Dietary Conjugated Linoleic Acid Modulates the Hepatic Circadian Clock Program via PPARα/REV-ERBα-Mediated Chromatin Modification in Mice.
Rev-erbα exacerbates hepatic steatosis in alcoholic liver diseases through regulating autophagy.
Dysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models.
The tight junction protein TJP1 regulates the feeding-modulated hepatic circadian clock.
The Nuclear Receptor and Clock Repressor Rev-erbα Suppresses Myogenesis.
NR1D1 enhances oxidative DNA damage by inhibiting PARP1 activity.
NR1D1 Recruitment to Sites of DNA Damage Inhibits Repair and Is Associated with Chemosensitivity of Breast Cancer.
Deletion of exons 3 and 4 in the mouse Nr1d1 gene worsens high-fat diet-induced hepatic steatosis.
Wang L, Hu L, Wang X, Geng Z, Wan M, Hao J, Liu H, Fan Y, Xu T, Li Z
Molecular metabolism 2024 Feb;80:101878
Molecular metabolism 2024 Feb;80:101878
Deciphering the diurnal rhythm regulating mechanism of flavin-containing monooxygenase 3 in mouse liver.
Huang M, Duan S, Zhang Q, Guo L, Qin Z, Yang J
The international journal of biochemistry & cell biology 2024 Apr;169:106538
The international journal of biochemistry & cell biology 2024 Apr;169:106538
REV-ERBα negatively regulates NLRP6 transcription and reduces the severity of Salmonella infection in mice.
Sun L, Huang K, Deng Q, Zhu Y, Cao Y, Dong K, Yang S, Li Y, Wu S, Huang R
Heliyon 2024 Apr 30;10(8):e28432
Heliyon 2024 Apr 30;10(8):e28432
Mitophagy Regulates the Circadian Rhythms by Degrading NR1D1 in Simulated Microgravity and Isolation Environments.
Zhou S, Li X, Liang F, Ji G, Lv K, Yuan Y, Zhao Y, Yan N, Zhang C, Cai S, Zhang S, Liu X, Song B, Qu L
International journal of molecular sciences 2024 Apr 29;25(9)
International journal of molecular sciences 2024 Apr 29;25(9)
Melatonin alleviates depression-like behaviors and cognitive dysfunction in mice by regulating the circadian rhythm of AQP4 polarization.
Yao D, Li R, Hao J, Huang H, Wang X, Ran L, Fang Y, He Y, Wang W, Liu X, Wang M
Translational psychiatry 2023 Oct 6;13(1):310
Translational psychiatry 2023 Oct 6;13(1):310
LncRNA Nron deficiency protects mice from diet-induced adiposity and hepatic steatosis.
Liu B, Zhong Y, Huang D, Yang L, Wang P, Yang L, Zhang F, Li X, Liang M, Huang K, Du M
Metabolism: clinical and experimental 2023 Nov;148:155609
Metabolism: clinical and experimental 2023 Nov;148:155609
Regulation of BCRP expression and sulfasalazine pharmacokinetics by the nuclear receptor REV-ERBα.
Wu C, Xiao Y, Wu C, Xie D, Luo M, Yao D, Chen M, Lu D
Xenobiotica; the fate of foreign compounds in biological systems 2023 Mar;53(3):215-222
Xenobiotica; the fate of foreign compounds in biological systems 2023 Mar;53(3):215-222
m(6)A methylation-induced NR1D1 ablation disrupts the HSC circadian clock and promotes hepatic fibrosis.
Chen L, Xia S, Wang F, Zhou Y, Wang S, Yang T, Li Y, Xu M, Zhou Y, Kong D, Zhang Z, Shao J, Xu X, Zhang F, Zheng S
Pharmacological research 2023 Mar;189:106704
Pharmacological research 2023 Mar;189:106704
Alleviation of Limosilactobacillus reuteri in polycystic ovary syndrome protects against circadian dysrhythmia-induced dyslipidemia via capric acid and GALR1 signaling.
Li S, Zhai J, Chu W, Geng X, Wang D, Jiao L, Lu G, Chan WY, Sun K, Sun Y, Chen ZJ, Du Y
NPJ biofilms and microbiomes 2023 Jul 8;9(1):47
NPJ biofilms and microbiomes 2023 Jul 8;9(1):47
Jujuboside A ameliorates cognitive deficiency in delirium through promoting hippocampal E4BP4 in mice.
Du J, Zhang F, Chen M, Xiao Y, Zhang L, Dong L, Dong D, Wu B
The Journal of pharmacy and pharmacology 2023 Jul 5;75(7):886-897
The Journal of pharmacy and pharmacology 2023 Jul 5;75(7):886-897
NR1D1 deficiency in the tumor microenvironment promotes lung tumor development by activating the NLRP3 inflammasome.
Kim SM, Jeon Y, Jang JY, Lee H
Cell death discovery 2023 Jul 31;9(1):278
Cell death discovery 2023 Jul 31;9(1):278
Molecular components of the circadian clock regulate HIV-1 replication.
Borrmann H, Ulkar G, Kliszczak AE, Ismed D, Schilling M, Magri A, Harris JM, Balfe P, Vasudevan S, Borrow P, Zhuang X, McKeating JA
iScience 2023 Jul 21;26(7):107007
iScience 2023 Jul 21;26(7):107007
Fluoxetine Decreases Phagocytic Function via REV-ERBα in Microglia.
Jang DY, Yang B, You MJ, Rim C, Kim HJ, Sung S, Kwon MS
Neurochemical research 2023 Jan;48(1):196-209
Neurochemical research 2023 Jan;48(1):196-209
BMAL1 regulates Propionibacterium acnes-induced skin inflammation via REV-ERBα in mice.
Li F, Lin L, He Y, Sun G, Dong D, Wu B
International journal of biological sciences 2022;18(6):2597-2608
International journal of biological sciences 2022;18(6):2597-2608
PPAR-γ integrates obesity and adipocyte clock through epigenetic regulation of Bmal1.
Wang S, Lin Y, Gao L, Yang Z, Lin J, Ren S, Li F, Chen J, Wang Z, Dong Z, Sun P, Wu B
Theranostics 2022;12(4):1589-1606
Theranostics 2022;12(4):1589-1606
The actin cytoskeleton-MRTF/SRF cascade transduces cellular physical niche cues to entrain the circadian clock.
Xiong X, Li W, Nam J, Qu M, Kay SA, Ma K
Journal of cell science 2022 Oct 1;135(19)
Journal of cell science 2022 Oct 1;135(19)
The nuclear receptor REV-ERBα regulates CYP2E1 expression and acetaminophen hepatotoxicity.
Zhang L, Zhang F, Xiao Y, Du J, Zhang X, Chen M, Wu B
Xenobiotica; the fate of foreign compounds in biological systems 2022 Jun;52(6):633-643
Xenobiotica; the fate of foreign compounds in biological systems 2022 Jun;52(6):633-643
The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson's disease via the microglial NLRP3 inflammasome.
Kou L, Chi X, Sun Y, Han C, Wan F, Hu J, Yin S, Wu J, Li Y, Zhou Q, Zou W, Xiong N, Huang J, Xia Y, Wang T
Journal of neuroinflammation 2022 Jun 6;19(1):133
Journal of neuroinflammation 2022 Jun 6;19(1):133
Dark-light cycle disrupts bone metabolism and suppresses joint deterioration in osteoarthritic rats.
Song X, Zhao M, Tang J, Ma T, Bai H, Wang X, Liu L, Li T, Xu X, Sheng X, Zhao B, Wang Y, Wang T, Guo Y, Zhang X, Gao L
Arthritis research & therapy 2022 Jun 28;24(1):158
Arthritis research & therapy 2022 Jun 28;24(1):158
Dietary Conjugated Linoleic Acid Modulates the Hepatic Circadian Clock Program via PPARα/REV-ERBα-Mediated Chromatin Modification in Mice.
Liu HY, Gu H, Li Y, Hu P, Yang Y, Li K, Li H, Zhang K, Zhou B, Wu H, Bao W, Cai D
Frontiers in nutrition 2021;8:711398
Frontiers in nutrition 2021;8:711398
Rev-erbα exacerbates hepatic steatosis in alcoholic liver diseases through regulating autophagy.
Liu Q, Xu L, Wu M, Zhou Y, Yang J, Huang C, Xu T, Li J, Zhang L
Cell & bioscience 2021 Jul 10;11(1):129
Cell & bioscience 2021 Jul 10;11(1):129
Dysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models.
Zhang T, Yu F, Xu H, Chen M, Chen X, Guo L, Zhou C, Xu Y, Wang F, Yu J, Wu B
Nature communications 2021 Feb 22;12(1):1216
Nature communications 2021 Feb 22;12(1):1216
The tight junction protein TJP1 regulates the feeding-modulated hepatic circadian clock.
Liu Y, Zhang Y, Li T, Han J, Wang Y
Nature communications 2020 Jan 30;11(1):589
Nature communications 2020 Jan 30;11(1):589
The Nuclear Receptor and Clock Repressor Rev-erbα Suppresses Myogenesis.
Chatterjee S, Yin H, Li W, Lee J, Yechoor VK, Ma K
Scientific reports 2019 Mar 14;9(1):4585
Scientific reports 2019 Mar 14;9(1):4585
NR1D1 enhances oxidative DNA damage by inhibiting PARP1 activity.
Ka NL, Na TY, Lee MO
Molecular and cellular endocrinology 2017 Oct 15;454:87-92
Molecular and cellular endocrinology 2017 Oct 15;454:87-92
NR1D1 Recruitment to Sites of DNA Damage Inhibits Repair and Is Associated with Chemosensitivity of Breast Cancer.
Ka NL, Na TY, Na H, Lee MH, Park HS, Hwang S, Kim IY, Seong JK, Lee MO
Cancer research 2017 May 1;77(9):2453-2463
Cancer research 2017 May 1;77(9):2453-2463
Deletion of exons 3 and 4 in the mouse Nr1d1 gene worsens high-fat diet-induced hepatic steatosis.
Na H, Lee H, Lee MH, Lim HJ, Kim HJ, Jeon Y, Kang HL, Lee MO
Life sciences 2016 Dec 1;166:13-19
Life sciences 2016 Dec 1;166:13-19
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 14506-1-AP( NR1D1 Antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The NR1D1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human NR1D1. This antibody recognizes human, mouse antigen. The NR1D1 antibody has been validated for the following applications: ELISA, WB, IP analysis.
