14506-1-AP

antibody from Proteintech Group

Targeting: NR1D1 ear-1, hRev, Rev-ErbAalpha, REVERBA, REVERBalpha, THRA1, THRAL

Provider product page for 14506-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [43]
Comments [0]
Validations
Western blot [1]
Immunoprecipitation [1]

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Product number: 14506-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14506-1-AP, RRID:AB_11182604
Product name: NR1D1 antibody
Antibody type: Polyclonal
Description: KD/KO validated NR1D1 antibody (Cat. #14506-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IP, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

NR1D1 protein structure - 14506-1-AP shown in red.

Submitted references Downregulation of RORα by alcohol promotes TGFβ and α-SMA expression in mouse lung fibroblasts.

Fan X, Tao H, Kang BY, Diaz N, Baba K, Tosini G, Guo J, Yeligar SM, Sueblinvong V
Frontiers in medicine 2026;13:1719787

Targeting Wnt/β-catenin and circadian regulator restores PRC2/EZH2-controlled chromatin bivalency and suppresses cell state diversity.

Yang Y, Zhang X, Venkadakrishnan VB, Zou H, Zheng X, Guo S, Chen CZ, Borowsky AD, Corey E, Evans RM, Gao AC, Dall'Era MA, Zoubeidi A, Lara PN, Kung HJ, Chen X, Beltran H, Chen HW
The Journal of clinical investigation 2026 May 1;136(9)

Integrative study reveals NR1D1 mediates Hedyotis diffusa's antifibrosis via hypoxia inducible factor-1/ammonia axis.

Xia SW, Liu H, Yang KY, Gao YJ, Zhang MR, Zhou JW, Kong DS, Wu HY, Zhang F, Chen L
World journal of gastroenterology 2026 Mar 14;32(10):115334

Macrophage-specific UBA1 knockout attenuates sepsis-induced liver dysfunction by regulating inflammatory responses via the BMAL1/CLOCK-REV-ERBα axis.

Jin LY, Cui C, Lv SY, Li HH
International immunopharmacology 2026 Jan 1;168(Pt 1):115799

Time-Restricted Feeding Affects Energy Metabolism in Lactating Striped Hamsters (Cricetulus barabensis, Cricetidae, Rodentia).

Li W, Dong X, He J, Jin X, Yin B, Bo T, Wen J
Biology 2025 Sep 12;14(9)

Nuclear receptor Nr1d1 links sleep deprivation to intestinal homeostasis via microbiota-derived taurine.

Wang Z, Zhou L, Zheng Y, Zhong X, Huang R, Sun W, Wang S, Li W
Journal of translational medicine 2025 Oct 15;23(1):1106

A novel nuclear receptor NR1D1 suppresses HSD17B12 transcription to regulate granulosa cell apoptosis and autophagy via the AMPK pathway in sheep.

Cai Y, Xu H, Deng K, Yang H, Zhao B, Zhang C, Li S, Wei Z, Wang Z, Wang F, Zhang Y
International journal of biological macromolecules 2025 May;306(Pt 1):141271

Dihydroartemisinin requires NR1D1 mediated Rab7 ubiquitination to regulate hepatic stellate cells lipophagy in liver fibrosis.

Bao Z, Xu M, Kan Y, Guo X, Li M, Wang J, Zhou Y, Zhang Z, Shao J, Zhang F, Chen L, Zheng S, Xuan J
International journal of biological macromolecules 2025 May;305(Pt 1):141055

The integration of scRNA-seq with microarray and in-vivo experiments facilitates a comprehensive elucidation of the molecular mechanisms underlying endothelial cell involvement in myocardial infarction.

Mao L, Zhang Q, Wu Q, Zhang Y, Jiang J, Li Z, Chen L, Wang R, Zeng Q, Ren Y, Liu P, Liu M, Luo G
Biochemical and biophysical research communications 2025 Jun 20;766:151820

SR9009 attenuates TGF-β1-induced renal fibrotic responses by inhibiting the NOX4/p38 signaling pathway in NRK-49F cells.

Takaguri A, Shinohe S, Noro R, Sakuraba M, Satoh C, Ohashi R, Satoh K
European journal of pharmacology 2025 Jan 15;987:177162

Intestinal clock shapes sleep-wake cycle via sustaining glutamine homeostasis.

Guo L, Xiao Y, Li Z, Huang Y, Cen H, Wu Z, Wang H, Liu X, Yang Z, Zhao C, Hao T, Chen H, Jin M, Lu D, Chen M, Wu B
Cell metabolism 2025 Dec 2;37(12):2423-2437.e6

Molecular circadian clock disruption in the leukocytes of individuals with type 2 diabetes and overweight, and its relationship with leukocyte-endothelial interactions.

Luna-Marco C, Devos D, Cacace J, Fernandez-Reyes M, Díaz-Pozo P, Salazar JD, Solá E, Morillas C, Rocha M, Víctor VM, Rovira-Llopis S
Diabetologia 2024 Oct;67(10):2316-2328

Secretome from estrogen-responding human placenta-derived mesenchymal stem cells rescues ovarian function and circadian rhythm in mice with cyclophosphamide-induced primary ovarian insufficiency.

Le DC, Ngo MT, Kuo YC, Chen SH, Lin CY, Ling TY, Pham QTT, Au HK, Myung J, Huang YH
Journal of biomedical science 2024 Oct 11;31(1):95

Sulforaphane Improves Liver Metabolism and Gut Microbiota in Circadian Rhythm Disorder Mice Models Fed With High-Fat Diets.

He C, Chen M, Jiang X, Ren J, Ganapathiraju SV, Lei P, Yang H, Pannu PR, Zhao Y, Zhang X
Molecular nutrition & food research 2024 Nov;68(21):e2400535

Long non-coding RNA LncCplx2 regulates glucose homeostasis and pancreatic β cell function.

Wang L, Hu L, Wang X, Geng Z, Wan M, Hao J, Liu H, Fan Y, Xu T, Li Z
Molecular metabolism 2024 Feb;80:101878

Parenteral nutrition results in peripheral ileal to hepatic circadian discordance in mice.

Shearn CT, Anderson AL, Devereaux MW, Sokol RJ
American journal of physiology. Gastrointestinal and liver physiology 2024 Dec 1;327(6):G754-G764

Deciphering the diurnal rhythm regulating mechanism of flavin-containing monooxygenase 3 in mouse liver.

Huang M, Duan S, Zhang Q, Guo L, Qin Z, Yang J
The international journal of biochemistry & cell biology 2024 Apr;169:106538

REV-ERBα negatively regulates NLRP6 transcription and reduces the severity of Salmonella infection in mice.

Sun L, Huang K, Deng Q, Zhu Y, Cao Y, Dong K, Yang S, Li Y, Wu S, Huang R
Heliyon 2024 Apr 30;10(8):e28432

Mitophagy Regulates the Circadian Rhythms by Degrading NR1D1 in Simulated Microgravity and Isolation Environments.

Zhou S, Li X, Liang F, Ji G, Lv K, Yuan Y, Zhao Y, Yan N, Zhang C, Cai S, Zhang S, Liu X, Song B, Qu L
International journal of molecular sciences 2024 Apr 29;25(9)

Expression of circadian regulatory genes is dysregulated by increased cytokine production in mice subjected to concomitant intestinal injury and parenteral nutrition.

Shearn CT, Anderson AL, Devereaux MW, El Kasmi KC, Orlicky DJ, Sokol RJ
PloS one 2023;18(8):e0290385

Melatonin alleviates depression-like behaviors and cognitive dysfunction in mice by regulating the circadian rhythm of AQP4 polarization.

Yao D, Li R, Hao J, Huang H, Wang X, Ran L, Fang Y, He Y, Wang W, Liu X, Wang M
Translational psychiatry 2023 Oct 6;13(1):310

LncRNA Nron deficiency protects mice from diet-induced adiposity and hepatic steatosis.

Liu B, Zhong Y, Huang D, Yang L, Wang P, Yang L, Zhang F, Li X, Liang M, Huang K, Du M
Metabolism: clinical and experimental 2023 Nov;148:155609

Regulation of BCRP expression and sulfasalazine pharmacokinetics by the nuclear receptor REV-ERBα.

Wu C, Xiao Y, Wu C, Xie D, Luo M, Yao D, Chen M, Lu D
Xenobiotica; the fate of foreign compounds in biological systems 2023 Mar;53(3):215-222

m(6)A methylation-induced NR1D1 ablation disrupts the HSC circadian clock and promotes hepatic fibrosis.

Chen L, Xia S, Wang F, Zhou Y, Wang S, Yang T, Li Y, Xu M, Zhou Y, Kong D, Zhang Z, Shao J, Xu X, Zhang F, Zheng S
Pharmacological research 2023 Mar;189:106704

Alleviation of Limosilactobacillus reuteri in polycystic ovary syndrome protects against circadian dysrhythmia-induced dyslipidemia via capric acid and GALR1 signaling.

Li S, Zhai J, Chu W, Geng X, Wang D, Jiao L, Lu G, Chan WY, Sun K, Sun Y, Chen ZJ, Du Y
NPJ biofilms and microbiomes 2023 Jul 8;9(1):47

Jujuboside A ameliorates cognitive deficiency in delirium through promoting hippocampal E4BP4 in mice.

Du J, Zhang F, Chen M, Xiao Y, Zhang L, Dong L, Dong D, Wu B
The Journal of pharmacy and pharmacology 2023 Jul 5;75(7):886-897

NR1D1 deficiency in the tumor microenvironment promotes lung tumor development by activating the NLRP3 inflammasome.

Kim SM, Jeon Y, Jang JY, Lee H
Cell death discovery 2023 Jul 31;9(1):278

Molecular components of the circadian clock regulate HIV-1 replication.

Borrmann H, Ulkar G, Kliszczak AE, Ismed D, Schilling M, Magri A, Harris JM, Balfe P, Vasudevan S, Borrow P, Zhuang X, McKeating JA
iScience 2023 Jul 21;26(7):107007

Fluoxetine Decreases Phagocytic Function via REV-ERBα in Microglia.

Jang DY, Yang B, You MJ, Rim C, Kim HJ, Sung S, Kwon MS
Neurochemical research 2023 Jan;48(1):196-209

BMAL1 regulates Propionibacterium acnes-induced skin inflammation via REV-ERBα in mice.

Li F, Lin L, He Y, Sun G, Dong D, Wu B
International journal of biological sciences 2022;18(6):2597-2608

PPAR-γ integrates obesity and adipocyte clock through epigenetic regulation of Bmal1.

Wang S, Lin Y, Gao L, Yang Z, Lin J, Ren S, Li F, Chen J, Wang Z, Dong Z, Sun P, Wu B
Theranostics 2022;12(4):1589-1606

The actin cytoskeleton-MRTF/SRF cascade transduces cellular physical niche cues to entrain the circadian clock.

Xiong X, Li W, Nam J, Qu M, Kay SA, Ma K
Journal of cell science 2022 Oct 1;135(19)

The nuclear receptor REV-ERBα regulates CYP2E1 expression and acetaminophen hepatotoxicity.

Zhang L, Zhang F, Xiao Y, Du J, Zhang X, Chen M, Wu B
Xenobiotica; the fate of foreign compounds in biological systems 2022 Jun;52(6):633-643

The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson's disease via the microglial NLRP3 inflammasome.

Kou L, Chi X, Sun Y, Han C, Wan F, Hu J, Yin S, Wu J, Li Y, Zhou Q, Zou W, Xiong N, Huang J, Xia Y, Wang T
Journal of neuroinflammation 2022 Jun 6;19(1):133

Dark-light cycle disrupts bone metabolism and suppresses joint deterioration in osteoarthritic rats.

Song X, Zhao M, Tang J, Ma T, Bai H, Wang X, Liu L, Li T, Xu X, Sheng X, Zhao B, Wang Y, Wang T, Guo Y, Zhang X, Gao L
Arthritis research & therapy 2022 Jun 28;24(1):158

Dietary Conjugated Linoleic Acid Modulates the Hepatic Circadian Clock Program via PPARα/REV-ERBα-Mediated Chromatin Modification in Mice.

Liu HY, Gu H, Li Y, Hu P, Yang Y, Li K, Li H, Zhang K, Zhou B, Wu H, Bao W, Cai D
Frontiers in nutrition 2021;8:711398

Rev-erbα exacerbates hepatic steatosis in alcoholic liver diseases through regulating autophagy.

Liu Q, Xu L, Wu M, Zhou Y, Yang J, Huang C, Xu T, Li J, Zhang L
Cell & bioscience 2021 Jul 10;11(1):129

Dysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models.

Zhang T, Yu F, Xu H, Chen M, Chen X, Guo L, Zhou C, Xu Y, Wang F, Yu J, Wu B
Nature communications 2021 Feb 22;12(1):1216

The tight junction protein TJP1 regulates the feeding-modulated hepatic circadian clock.

Liu Y, Zhang Y, Li T, Han J, Wang Y
Nature communications 2020 Jan 30;11(1):589

The Nuclear Receptor and Clock Repressor Rev-erbα Suppresses Myogenesis.

Chatterjee S, Yin H, Li W, Lee J, Yechoor VK, Ma K
Scientific reports 2019 Mar 14;9(1):4585

NR1D1 enhances oxidative DNA damage by inhibiting PARP1 activity.

Ka NL, Na TY, Lee MO
Molecular and cellular endocrinology 2017 Oct 15;454:87-92

NR1D1 Recruitment to Sites of DNA Damage Inhibits Repair and Is Associated with Chemosensitivity of Breast Cancer.

Ka NL, Na TY, Na H, Lee MH, Park HS, Hwang S, Kim IY, Seong JK, Lee MO
Cancer research 2017 May 1;77(9):2453-2463

Deletion of exons 3 and 4 in the mouse Nr1d1 gene worsens high-fat diet-induced hepatic steatosis.

Na H, Lee H, Lee MH, Lim HJ, Kim HJ, Jeon Y, Kang HL, Lee MO
Life sciences 2016 Dec 1;166:13-19

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 14506-1-AP( NR1D1 Antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The NR1D1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human NR1D1. This antibody recognizes human, mouse antigen. The NR1D1 antibody has been validated for the following applications: ELISA, WB, IP analysis.
Appendix: 14506-1-AP.pdf

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