BS8541

antibody from Bioworld Technology, Inc
Targeting: PPP1R8 ard-1, ARD1, NIPP-1, NIPP1, PRO2047
Provider product page for BS8541
Western blot
Immunohistochemistry

Antibody data

Product number
BS8541 - Provider product page
Provider
Bioworld Technology, Inc
Product name
NIPP1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Nuclear inhibitor of protein phosphatase 1; NIPP-1; Protein phosphatase 1 regulatory inhibitor subunit 8; Activator of RNA decay; ARD-1; PPP1R8; ARD1
Description
NIPP1 (nuclear inhibitor of protein phosphatase 1) is a putative transcription regulator that may be involved in pre-mRNA splicing and cell proliferation. NIPP1 contains a nuclear signaling region named FHA (fork-head associated) domain. The FHA domain has been associated with protein kinases and transcription factors. The NIPP1 locus encodes for three different isoforms termed Ï«, ÉÇ and ÎÛ due to alternative splicing events. The isoforms exhibit RNA binding activity and also act as phophatase inhibitors. The ÎÛ isoform is believed to be a magnesium dependent endoribonuclease that is responsible for cleaving RNA strands. It is mainly found in B cells and T lymphocytes. The Ï« and ÉÇ isoforms are localized in the brain and kidney. Inactivation of NIPP1 is accomplished by the phosphorylation of Ser 199 or Ser 204. NIPP1 interacts with proteins CDc5L, SAP 155, MELK and EED.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PPP1R8 protein structure - BS8541 shown in red.