Antibody data
- Antibody Data
- Antigen structure
- References [17]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 11640-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11640-1-AP, RRID:AB_2078519
- Product name
- CDC6 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CDC6 antibody (Cat. #11640-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Identification of PRDX5 as A Target for The Treatment of Castration-Resistant Prostate Cancer.
Identification and verification of hub genes associated with the progression of non-small cell lung cancer by integrated analysis.
Heat Stress Modulates a Placental Immune Response Associated With Alterations in the Development of the Fetal Intestine and Its Innate Immune System in Late Pregnant Mouse.
N-glycosylation of GDF15 abolishes its inhibitory effect on EGFR in AR inhibitor-resistant prostate cancer cells.
Norcantharidin Induces Immunogenic Cell Death of Bladder Cancer Cells through Promoting Autophagy in Acidic Culture.
Interactome analysis of gene expression profiles identifies CDC6 as a potential therapeutic target modified by miR-215-5p in hepatocellular carcinoma.
Circular RNA circNELL2 Acts as the Sponge of miR-127-5p to Promote Esophageal Squamous Cell Carcinoma Progression.
A novel LncRNA transcript, RBAT1, accelerates tumorigenesis through interacting with HNRNPL and cis-activating E2F3.
β-Elemene enhances radiosensitivity in non-small-cell lung cancer by inhibiting epithelial-mesenchymal transition and cancer stem cell traits via Prx-1/NF-kB/iNOS signaling pathway.
Phenotypic transition of tumor cells between epithelial- and mesenchymal-like state during adaptation to acidosis.
The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis.
PRMT5 competitively binds to CDK4 to promote G1-S transition upon glucose induction in hepatocellular carcinoma.
YB-1 promotes transcription of cyclin D1 in human non-small-cell lung cancers.
Histone deacetylase 2 (HDAC2) regulates chromosome segregation and kinetochore function via H4K16 deacetylation during oocyte maturation in mouse.
N-myc downstream regulated gene1/Cap43 overexpression suppresses tumor growth by hepatic cancer cells through cell cycle arrest at the G0/G1 phase.
Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase.
Y-box binding protein-1 (YB-1) promotes cell cycle progression through CDC6-dependent pathway in human cancer cells.
Wang R, Mi Y, Ni J, Wang Y, Ding L, Ran X, Sun Q, Tan SY, Koeffler HP, Feng N, Chen YQ
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(9):e2304939
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(9):e2304939
Identification and verification of hub genes associated with the progression of non-small cell lung cancer by integrated analysis.
Mengyan X, Kun D, Xinming J, Yutian W, Yongqian S
Frontiers in pharmacology 2022;13:997842
Frontiers in pharmacology 2022;13:997842
Heat Stress Modulates a Placental Immune Response Associated With Alterations in the Development of the Fetal Intestine and Its Innate Immune System in Late Pregnant Mouse.
Guo H, Liu R, He J, Yao W, Zheng W
Frontiers in physiology 2022;13:841149
Frontiers in physiology 2022;13:841149
N-glycosylation of GDF15 abolishes its inhibitory effect on EGFR in AR inhibitor-resistant prostate cancer cells.
Wang R, Wen P, Yang G, Feng Y, Mi Y, Wang X, Zhu S, Chen YQ
Cell death & disease 2022 Jul 19;13(7):626
Cell death & disease 2022 Jul 19;13(7):626
Norcantharidin Induces Immunogenic Cell Death of Bladder Cancer Cells through Promoting Autophagy in Acidic Culture.
Xu L, Su B, Mo L, Zhao C, Zhao Z, Li H, Hu Z, Li J
International journal of molecular sciences 2022 Apr 1;23(7)
International journal of molecular sciences 2022 Apr 1;23(7)
Interactome analysis of gene expression profiles identifies CDC6 as a potential therapeutic target modified by miR-215-5p in hepatocellular carcinoma.
Xu H, Huang J, Hua S, Liang L, He X, Zhan M, Lu L, Chu J
International journal of medical sciences 2020;17(18):2926-2940
International journal of medical sciences 2020;17(18):2926-2940
Circular RNA circNELL2 Acts as the Sponge of miR-127-5p to Promote Esophageal Squamous Cell Carcinoma Progression.
Xiong G, Diao D, Lu D, Liu X, Liu Z, Mai S, Feng S, Dong X, Cai K
OncoTargets and therapy 2020;13:9245-9255
OncoTargets and therapy 2020;13:9245-9255
A novel LncRNA transcript, RBAT1, accelerates tumorigenesis through interacting with HNRNPL and cis-activating E2F3.
He X, Chai P, Li F, Zhang L, Zhou C, Yuan X, Li Y, Yang J, Luo Y, Ge S, Zhang H, Jia R, Fan X
Molecular cancer 2020 Jul 15;19(1):115
Molecular cancer 2020 Jul 15;19(1):115
β-Elemene enhances radiosensitivity in non-small-cell lung cancer by inhibiting epithelial-mesenchymal transition and cancer stem cell traits via Prx-1/NF-kB/iNOS signaling pathway.
Zou K, Li Z, Zhang Y, Mu L, Chen M, Wang R, Deng W, Zou L, Liu J
Aging 2020 Dec 9;13(2):2575-2592
Aging 2020 Dec 9;13(2):2575-2592
Phenotypic transition of tumor cells between epithelial- and mesenchymal-like state during adaptation to acidosis.
Zhang Y, Xu L, Wang P, Jian H, Shi X, Jia M, Mo L, Hu Z, Li H, Li J
Cell cycle (Georgetown, Tex.) 2019 Aug;18(16):1938-1947
Cell cycle (Georgetown, Tex.) 2019 Aug;18(16):1938-1947
The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis.
Fan L, Cao X, Yan H, Wang Q, Tian X, Zhang L, He X, Borjihan G, Morigen
Oncotarget 2017 Jul 18;8(29):47250-47268
Oncotarget 2017 Jul 18;8(29):47250-47268
PRMT5 competitively binds to CDK4 to promote G1-S transition upon glucose induction in hepatocellular carcinoma.
Yang H, Zhao X, Zhao L, Liu L, Li J, Jia W, Liu J, Huang G
Oncotarget 2016 Nov 1;7(44):72131-72147
Oncotarget 2016 Nov 1;7(44):72131-72147
YB-1 promotes transcription of cyclin D1 in human non-small-cell lung cancers.
Harada M, Kotake Y, Ohhata T, Kitagawa K, Niida H, Matsuura S, Funai K, Sugimura H, Suda T, Kitagawa M
Genes to cells : devoted to molecular & cellular mechanisms 2014 Jun;19(6):504-16
Genes to cells : devoted to molecular & cellular mechanisms 2014 Jun;19(6):504-16
Histone deacetylase 2 (HDAC2) regulates chromosome segregation and kinetochore function via H4K16 deacetylation during oocyte maturation in mouse.
Ma P, Schultz RM
PLoS genetics 2013;9(3):e1003377
PLoS genetics 2013;9(3):e1003377
N-myc downstream regulated gene1/Cap43 overexpression suppresses tumor growth by hepatic cancer cells through cell cycle arrest at the G0/G1 phase.
Akiba J, Murakami Y, Noda M, Watari K, Ogasawara S, Yoshida T, Kawahara A, Sanada S, Yasumoto M, Yamaguchi R, Kage M, Kuwano M, Ono M, Yano H
Cancer letters 2011 Nov 1;310(1):25-34
Cancer letters 2011 Nov 1;310(1):25-34
Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase.
Yim H, Erikson RL
Proceedings of the National Academy of Sciences of the United States of America 2010 Nov 16;107(46):19742-7
Proceedings of the National Academy of Sciences of the United States of America 2010 Nov 16;107(46):19742-7
Y-box binding protein-1 (YB-1) promotes cell cycle progression through CDC6-dependent pathway in human cancer cells.
Basaki Y, Taguchi K, Izumi H, Murakami Y, Kubo T, Hosoi F, Watari K, Nakano K, Kawaguchi H, Ohno S, Kohno K, Ono M, Kuwano M
European journal of cancer (Oxford, England : 1990) 2010 Mar;46(5):954-65
European journal of cancer (Oxford, England : 1990) 2010 Mar;46(5):954-65
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 11640-1-AP(CDC6 antibody) at dilution of 1:400
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using CDC6 antibody 11640-1-AP at 1:50 and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 11640-1-AP(CDC6 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue