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Western blot
Other assayAntibody data
- Antibody Data
- Antigen structure
- References [6]
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- Validations
- Other assay [1]
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- Product number
- MA5-14314 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Cdc6 Monoclonal Antibody (DCS-180)
- Antibody type
- Monoclonal
- Antigen
- Recombinant full-length protein
- Description
- MA5-14314 targets CDC6 in IP and WB applications and shows reactivity with Human samples. The MA5-14314 immunogen is recombinant human CDC6 protein.
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- DCS-180
- Vial size
- 500 µL
- Concentration
- 0.2 mg/mL
- Storage
- 4° C
Submitted references The abundance of Rad51 protein in mouse embryonic stem cells is regulated at multiple levels.
Cdc6 protein activates p27KIP1-bound Cdk2 protein only after the bound p27 protein undergoes C-terminal phosphorylation.
Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1.
First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery.
RNA-dependent recruitment of the origin recognition complex.
Cell cycle regulation of the human Six1 homeoprotein is mediated by APC(Cdh1).
Tichy ED, Pillai R, Deng L, Tischfield JA, Hexley P, Babcock GF, Stambrook PJ
Stem cell research 2012 Sep;9(2):124-34
Stem cell research 2012 Sep;9(2):124-34
Cdc6 protein activates p27KIP1-bound Cdk2 protein only after the bound p27 protein undergoes C-terminal phosphorylation.
Uranbileg B, Yamamoto H, Park JH, Mohanty AR, Arakawa-Takeuchi S, Jinno S, Okayama H
The Journal of biological chemistry 2012 Feb 24;287(9):6275-83
The Journal of biological chemistry 2012 Feb 24;287(9):6275-83
Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1.
Tran K, Kamil JP, Coen DM, Spector DH
Journal of virology 2010 Oct;84(20):10832-43
Journal of virology 2010 Oct;84(20):10832-43
First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery.
Menichincheri M, Bargiotti A, Berthelsen J, Bertrand JA, Bossi R, Ciavolella A, Cirla A, Cristiani C, Croci V, D'Alessio R, Fasolini M, Fiorentini F, Forte B, Isacchi A, Martina K, Molinari A, Montagnoli A, Orsini P, Orzi F, Pesenti E, Pezzetta D, Pillan A, Poggesi I, Roletto F, Scolaro A, Tatò M, Tibolla M, Valsasina B, Varasi M, Volpi D, Santocanale C, Vanotti E
Journal of medicinal chemistry 2009 Jan 22;52(2):293-307
Journal of medicinal chemistry 2009 Jan 22;52(2):293-307
RNA-dependent recruitment of the origin recognition complex.
Norseen J, Thomae A, Sridharan V, Aiyar A, Schepers A, Lieberman PM
The EMBO journal 2008 Nov 19;27(22):3024-35
The EMBO journal 2008 Nov 19;27(22):3024-35
Cell cycle regulation of the human Six1 homeoprotein is mediated by APC(Cdh1).
Christensen KL, Brennan JD, Aldridge CS, Ford HL
Oncogene 2007 May 17;26(23):3406-14
Oncogene 2007 May 17;26(23):3406-14
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunoprecipitation of CDC6 using CDC6 Monoclonal Antibody (Product # MA5-14314) on Native Human Raji Cells.
