18374-1-AP

antibody from Proteintech Group

Targeting: ANGPTL4 ARP4, FIAF, HFARP, NL2, PGAR, pp1158

Provider product page for 18374-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [59]
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Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 18374-1-AP - Provider product page
Provider: Proteintech Group
Product name: ANGPTL4 antibody
Antibody type: Polyclonal
Description: ANGPTL4 antibody (Cat. #18374-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ANGPTL4 protein structure - 18374-1-AP shown in red.

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Txnrd2 loss in skeletal muscle causes muscle atrophy and drives leanness and obesity resistance.

Kiermayer C, Erdelen R, Schriever SC, Böhm R, Prehn C, Artati A, Kleinert M, Miller M, Dyar KA, Schmid RM, Pfluger PT, Adamski J, Brielmeier M
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Comprehensive analysis and validation of angiogenesis in vascular dementia from the perspective of diagnosis, prevention, and treatment.

Xu L, Wang Y, Xie D
Frontiers in genetics 2025;16:1646991

Cancer-associated fibroblasts regulate mitochondrial metabolism and inhibit chemosensitivity via ANGPTL4-IQGAP1 axis in prostate cancer.

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DDIT4 knockdown suppresses venous malformation progression by inhibiting NF-κB signaling as a potential therapeutic target.

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Environmental aminomethylphosphonic acid (AMPA) exposure increased the risk of spontaneous abortion through lactate-induced JunB lactylation in trophoblast.

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Unraveling cellular dynamic changes in tumor evolution induced by long-term low dose-rate radiation.

Li W, Pei W, Wang Y, Nie J, Hu G, Zhang Y, Cao Z, Chen Z, Miao K, Chen Y, Shi L, Dai Y, Liu N, Pei H, Ye C, Ali YF, Hu W, Yan W, Zhou G
British journal of cancer 2025 Nov;133(9):1278-1296

Lineage plasticity and signal dysregulation define the cellular trajectory of osteoarthritis progression.

Chen G, Tai K, Dai G
Clinical and experimental medicine 2025 Nov 25;26(1):41

Gestational exposure to PM(2.5) impaired cardiac development through ANGPTL4-mediated mitochondrial metabolic dysfunction.

Lv J, Ding R, Liang C, Tian L, Liu Z, Liu S, Xiong Z, Liu R, Sun Z, Yin C, Duan J
Journal of advanced research 2025 Nov 15;

Insight into perfluorooctanoic acid-induced impairment of mouse embryo implantation via single-cell RNA-seq.

Sheng X, Yang Y, Tian J, Zhang Z, Ding L, Zhao J
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Atf3 + senescent chondrocytes mediate meniscus degeneration in aging.

Wang JY, Liu YH, Wang X, Ma M, Pan ZY, Fan AY, Lu LY, Liu Z, Tao K, Yin F
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Effect of ranibizumab on diabetic retinopathy via the vascular endothelial growth factor/STAT3/glial fibrillary acidic protein pathway.

Lin YT, Tan J, Tao YL, Hu WW, Wang YC, Huang J, Zhou Q, Xiao A
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Identifying novel drug targets for calcific aortic valve disease through Mendelian randomization.

Xu D, Lu J, Yang Y, Hu W, Chen J, Xue J, Yang S, Cao N, Hu H, Qian N, Zhou D, Dai H, Wang J, Liu X
Atherosclerosis 2025 Mar;402:119110

ANGPTL4 induces Kupffer cell M2 polarization to mitigate acute rejection in liver transplantation.

Huang W, Jiang L, Jiang Y, Li S, Liu W, Zong K, Peng D, Wu Z, Huang Z
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Senolytic procyanidin C1 alleviates renal fibrosis by promoting apoptosis of senescent renal tubular epithelial cells.

Gan Y, Wang K, Chen X, Li Y, He Y, Zhou Y, Zhang B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jan 31;39(2):e70362

Targeting OxLDL-mediated CD36 + CAF reprogramming potentiates PD-1 immunotherapy in osteosarcoma.

Zeng A, Chen H, Luo T, Chen W, Song Y, Xu Y, Chen Z, Tang Q, Zhu X, Deng C, Xu H, Wang A, Wu H, Song G, Lu J, Wang J
Molecular cancer 2025 Dec 18;25(1):14

Machine learning-based identification of kbhb-affected tumor cell subsets as prognostic and therapeutic targets in breast cancer.

Yuan Q, Sha Y, Ye R, Yu H, Ni L, Han J, Deng L
Journal of translational medicine 2025 Dec 11;24(1):71

Solanum lyratum-Derived Solalyraine A1 Suppresses Non-Small Cell Lung Cancer Through Regulation of Exosome Secretion and Related Protein Biomarkers.

Jiang P, Liu L, Chen L, Han B, Du X
Pharmaceuticals (Basel, Switzerland) 2025 Aug 27;18(9)

Topical hADSCs-HA Gel Promotes Skin Regeneration and Angiogenesis in Pressure Ulcers by Paracrine Activating PPARβ/δ Pathway.

Jin C, Zhao R, Hu W, Wu X, Zhou L, Shan L, Wu H
Drug design, development and therapy 2024;18:4799-4824

The tourniquet's effects on skeletal muscle during total knee arthroplasty.

Johnsen M, Mousavizadeh R, Scott A, Havik S, Husby VS, Winther SB, Husby OS, Lian Ø
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ANGPTL4 promotes choroidal neovascularization and subretinal fibrosis through the endothelial‒mesenchymal transition.

Chen J, Yang Y, Su S, Zhang S, Huang J, Chen H, Yang X, Sang A
International ophthalmology 2024 Nov 26;44(1):441

Screening and validation of key genes associated with osteoarthritis.

He M, Yu Q, Xiao H, Dong H, Li D, Gu W
BMC musculoskeletal disorders 2024 Nov 25;25(1):954

Knockdown of ANGPTL4 inhibits adipogenesis of preadipocyte via autophagy.

Ling M, Qian H, Guo H
In vitro cellular & developmental biology. Animal 2024 Mar;60(3):258-265

Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota.

Li H, Zhang L, Li J, Wu Q, Qian L, He J, Ni Y, Kovatcheva-Datchary P, Yuan R, Liu S, Shen L, Zhang M, Sheng B, Li P, Kang K, Wu L, Fang Q, Long X, Wang X, Li Y, Ye Y, Ye J, Bao Y, Zhao Y, Xu G, Liu X, Panagiotou G, Xu A, Jia W
Nature metabolism 2024 Mar;6(3):578-597

Renal lipid accumulation and aging linked to tubular cells injury via ANGPTL4.

Wang X, Chang HC, Gu X, Han W, Mao S, Lu L, Jiang S, Ding H, Han S, Qu X, Bao Z
Mechanisms of ageing and development 2024 Jun;219:111932

Angiopoietin-like 4 is upregulated by amphiregulin and activates cell proliferation and migration through p38 kinase in head and neck squamous cell carcinoma.

Kumar A, Asiedu E, Hefni E, Armstrong C, Menon D, Ma T, Sands L, Mbadugha E, Sodhi A, Schneider A, Montaner S
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2024 Jul;53(6):366-375

The ANGPTL4-HIF-1α loop: a critical regulator of renal interstitial fibrosis.

Li Y, Chen S, Yang Q, Liu X, Zhou W, Kang T, Wu W, Ou S
Journal of translational medicine 2024 Jul 11;22(1):649

Egr-1 is a key regulator of the blood-brain barrier damage induced by meningitic Escherichia coli.

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Wu J, Zhang Y, You G, Guo W, Wang Y, Li J, Tan R, Fu X, Tang Y, Zan J, Su J
Aging 2024 Feb 9;16(3):2887-2907

ANGPTL4-mediated microglial lipid droplet accumulation: Bridging Alzheimer's disease and obesity.

Li N, Wang X, Lin R, Yang F, Chang HC, Gu X, Shu J, Liu G, Yu Y, Wei W, Bao Z
Neurobiology of disease 2024 Dec;203:106741

Bone-protective effects of neutralizing angiopoietin-like protein 4 monoclonal antibody in rheumatoid arthritis.

Ke L, He Q, Qu J, Wang X, Li K, Gong X, Li L, Xu J, Yu Q, Yu H, Lin X, Li J, Tan NS, Sun W, Li L, Zhang P, Cheng W
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Dec 4;32(12):4497-4513

ANGPTL4 mediated mesothelial-mesenchymal transition in pulmonary fibrosis: a potential therapeutic target.

Xia Y, Zhou F, Hui H, Dai L, Ouyang S
Journal of translational medicine 2024 Dec 20;22(1):1114

Single-cell multi-omics analysis reveals candidate therapeutic drugs and key transcription factor specifically for the mesenchymal subtype of glioblastoma.

Yang Y, Liu Z, Wei Y, He S, Gu A, Li Z, Li J, Xu Z, Cen B
Cell & bioscience 2024 Dec 20;14(1):151

Protective Effects of Dioscin and Diosgenin on Plateau Hyperuricemia by Attenuating Renal Inflammation via EPHX2.

Dang W, Li F, Gao R, Zhang C, Cheng H, Wu Z, Yang T, Pan J, Tang X, Gao Y
International journal of molecular sciences 2024 Dec 13;25(24)

Shen X, Xie J, Liu S, Cai Y, Yuan S, Uehara Y, Zhu D, Zheng M
Journal of thoracic disease 2024 Aug 31;16(8):5361-5378

Angiopoietin-like 4 Is a Critical Regulator of Fibroblasts during Pulmonary Fibrosis Development.

Saito S, Kitabatake M, Ouji-Sageshima N, Ogawa T, Oda A, Nishimura T, Nishioka T, Fushimi S, Hara A, Shichino S, Kumamoto M, Hontsu S, Kawaguchi T, Ueha S, Sawabata N, Muro S, Matsushima K, Ito T
American journal of respiratory cell and molecular biology 2023 Sep;69(3):328-339

High glucose-induced IL-7/IL-7R upregulation of dermal fibroblasts inhibits angiogenesis in a paracrine way in delayed diabetic wound healing.

Gao R, Zhou P, Li Y, Li Q
Journal of cell communication and signaling 2023 Sep;17(3):1023-1038

Adipocytes promote pancreatic cancer migration and invasion through fatty acid metabolic reprogramming.

Cai Z, Li Y, Ma M, Wang L, Wang H, Liu M, Jiang C
Oncology reports 2023 Jul;50(1)

N-acetylglucosamine-bearing polymers mimicking O-GlcNAc-modified proteins elicit anti-fibrotic activities in myofibroblasts and activated stellate cells.

Ise H, Araki Y, Song I, Akatsuka G
Glycobiology 2023 Jan 8;33(1):17-37

Angiopoietin-like 4 induces head and neck squamous cell carcinoma cell migration through the NRP1/ABL1/PXN pathway.

Hefni E, Menon D, Ma T, Asiedu EB, Sultan A, Meiller T, Schneider A, Sodhi A, Montaner S
Cellular signalling 2023 Aug;108:110697

ANGPTL4 regulates the osteogenic differentiation of periodontal ligament stem cells.

Xu L, Wang C, Li Y, Wang Y, Fu B, Yang G
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Angiopoietin-like 4 promotes glucose metabolism by regulating glucose transporter expression in colorectal cancer.

Mizuno S, Seishima R, Yamasaki J, Hattori K, Ogiri M, Matsui S, Shigeta K, Okabayashi K, Nagano O, Li L, Kitagawa Y
Journal of cancer research and clinical oncology 2022 Jun;148(6):1351-1361

ManNAc protects against podocyte pyroptosis via inhibiting mitochondrial damage and ROS/NLRP3 signaling pathway in diabetic kidney injury model.

Gao Y, Ma Y, Xie D, Jiang H
International immunopharmacology 2022 Jun;107:108711

Integrative Proteomic and Phosphoproteomic Analyses of Hypoxia-Treated Pulmonary Artery Smooth Muscle Cells.

Luo A, Hao R, Zhou X, Jia Y, Tang H
Proteomes 2022 Jun 28;10(3)

Allobaculum Involves in the Modulation of Intestinal ANGPTLT4 Expression in Mice Treated by High-Fat Diet.

Zheng Z, Lyu W, Ren Y, Li X, Zhao S, Yang H, Xiao Y
Frontiers in nutrition 2021;8:690138

Expression of ANGPTL4 in Nucleus Pulposus Tissues Is Associated with Intervertebral Disc Degeneration.

Liu FJ, Xie LY, Li HZ, Cao SN, Chen YZ, Bin-Shi, Wang DD
Disease markers 2021;2021:3532716

Baicalein Enhances the Effect of Acarbose on the Improvement of Nonalcoholic Fatty Liver Disease Associated with Prediabetes via the Inhibition of De Novo Lipogenesis.

Xing Y, Ren X, Li X, Sui L, Shi X, Sun Y, Quan C, Xiu Z, Dong Y
Journal of agricultural and food chemistry 2021 Sep 1;69(34):9822-9836

Banxia Baizhu Tianma decoction attenuates obesity-related hypertension.

Jiang YH, Zhang P, Tao Y, Liu Y, Cao G, Zhou L, Yang CH
Journal of ethnopharmacology 2021 Feb 10;266:113453

Decreased ANGPTL4 impairs endometrial angiogenesis during peri-implantation period in patients with recurrent implantation failure.

Li M, Hu J, Yao L, Gao M
Journal of cellular and molecular medicine 2020 Sep;24(18):10730-10743

Angiopoietin-Like Protein 4 (ANGPTL4) Induces Retinal Pigment Epithelial Barrier Breakdown by Activating Signal Transducer and Activator of Transcription 3 (STAT3): Evidence from ARPE-19 Cells Under Hypoxic Condition and Diabetic Rats.

Yang X, Cao J, Du Y, Gong Q, Cheng Y, Su G
Medical science monitor : international medical journal of experimental and clinical research 2019 Sep 8;25:6742-6754

LncRNA HAND2-AS1 promotes liver cancer stem cell self-renewal via BMP signaling.

Wang Y, Zhu P, Luo J, Wang J, Liu Z, Wu W, Du Y, Ye B, Wang D, He L, Ren W, Wang J, Sun X, Chen R, Tian Y, Fan Z
The EMBO journal 2019 Sep 2;38(17):e101110

Angiopoietin-like 4 binds neuropilins and cooperates with VEGF to induce diabetic macular edema.

Sodhi A, Ma T, Menon D, Deshpande M, Jee K, Dinabandhu A, Vancel J, Lu D, Montaner S
The Journal of clinical investigation 2019 Nov 1;129(11):4593-4608

Retrodifferentiation of Human Tumor Hepatocytes to Stem Cells Leads to Metabolic Reprogramming and Chemoresistance.

Fekir K, Dubois-Pot-Schneider H, Désert R, Daniel Y, Glaise D, Rauch C, Morel F, Fromenty B, Musso O, Cabillic F, Corlu A
Cancer research 2019 Apr 15;79(8):1869-1883

The long non-coding RNA PVT1 represses ANGPTL4 transcription through binding with EZH2 in trophoblast cell.

Xu Y, Lian Y, Zhang Y, Huang S, Zuo Q, Yang N, Chen Y, Wu D, Sun L
Journal of cellular and molecular medicine 2018 Feb;22(2):1272-1282

ANGPTL4 promotes the progression of cutaneous melanoma to brain metastasis.

Izraely S, Ben-Menachem S, Sagi-Assif O, Meshel T, Marzese DM, Ohe S, Zubrilov I, Pasmanik-Chor M, Hoon DSB, Witz IP
Oncotarget 2017 Sep 29;8(44):75778-75796

Hypoxia-induced angiopoietin-like protein 4 as a clinical biomarker and treatment target for human prostate cancer.

Hata S, Nomura T, Iwasaki K, Sato R, Yamasaki M, Sato F, Mimata H
Oncology reports 2017 Jul;38(1):120-128

ANGPTL4-αvβ3 interaction counteracts hypoxia-induced vascular permeability by modulating Src signalling downstream of vascular endothelial growth factor receptor 2.

Gomez Perdiguero E, Liabotis-Fontugne A, Durand M, Faye C, Ricard-Blum S, Simonutti M, Augustin S, Robb BM, Paques M, Valenzuela DM, Murphy AJ, Yancopoulos GD, Thurston G, Galaup A, Monnot C, Germain S
The Journal of pathology 2016 Dec;240(4):461-471

An integrated genomic approach identifies persistent tumor suppressive effects of transforming growth factor-β in human breast cancer.

Sato M, Kadota M, Tang B, Yang HH, Yang YA, Shan M, Weng J, Welsh MA, Flanders KC, Nagano Y, Michalowski AM, Clifford RJ, Lee MP, Wakefield LM
Breast cancer research : BCR 2014 Jun 2;16(3):R57

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HEK-293 cells were subjected to SDS PAGE followed by western blot with 18374-1-AP(ANGPTL4 antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The ANGPTL4 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human ANGPTL4. This antibody recognizes human, mouse antigen. The ANGPTL4 antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Appendix: 18374-1-AP.pdf

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