Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Blocking/Neutralizing [1]
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Validation data
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- Product number
- MAB8041 - Provider product page
- Provider
- R&D Systems
- Product name
- Human IGFBP-4 Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from ascites. Detects human IGFBP-4 in ELISAs and Western blots.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
AAA62670
- Isotype
- IgG
- Antibody clone number
- 82314
- Vial size
- 500 ug
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Steroids and protein markers in the follicular fluid as indicators of oocyte quality in patients with and without endometriosis.
Steroids and protein markers in the follicular fluid as indicators of oocyte quality in patients with and without endometriosis.
Wunder DM, Mueller MD, Birkhäuser MH, Bersinger NA
Journal of assisted reproduction and genetics 2005 Jun;22(6):257-64
Journal of assisted reproduction and genetics 2005 Jun;22(6):257-64
Steroids and protein markers in the follicular fluid as indicators of oocyte quality in patients with and without endometriosis.
Wunder DM, Mueller MD, Birkhäuser MH, Bersinger NA
Journal of assisted reproduction and genetics 2005 Jun;22(6):257-64
Journal of assisted reproduction and genetics 2005 Jun;22(6):257-64
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Supportive validation
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- R&D Systems (provider)
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- Experimental details
- IGFBP-4 Inhibition of IGF-II-dependent Cell Proliferation and Neutralization by Human IGFBP-4 Antibody. Recombinant Human IGFBP-4 (Catalog # 804-GB) inhibits Recombinant Human IGF-II (Catalog # 292-G2) induced proliferation in the MCF-7 human breast cancer cell line in a dose-dependent manner (orange line). Inhibition of Recombinant Human IGF-II (14 ng/mL) activity elicited by Recombinant Human IGFBP-4 (0.3 µg/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-Human IGFBP-4 Monoclonal Antibody (Catalog # MAB8041). The ND50 is typically 20-80 µg/mL.