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- Product number
- 10624-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10624-2-AP, RRID:AB_2100801
- Product name
- FASN antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated FASN antibody (Cat. #10624-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references NUDT7 Modulates the UBA52-SREBF1 Signaling Axis to Promote PRRSV Replication via Lipid Synthesis.
Gut-Derived Hippuric Acid Alleviates Hepatic Lipid Metabolism via UGDH/FOXK1/CD36 Axis in Obese Mice.
Qingyi Decoction Alleviates Alcoholic Pancreatitis by Improving Glycerolipid Homeostasis via the AMPK/SREBP-1c/PPARα Pathway.
The D826V point mutation in IREB2 induces lipogenesis in adipose tissues.
Integrating network toxicology and experimental validation to elucidate the molecular mechanism basis of chondrotoxicity of Benzo[a]pyrene in osteoarthritis.
Hepatic IFRD1 suppresses metabolic dysfunction-associated fatty liver disease via GLUD1/α-KG axis.
N-acetylglucosamine ameliorates the transition from acute kidney injury to chronic kidney disease by reducing the accumulation of lipid droplets.
STING-mediated metabolic reprogramming drives lipid peroxidation during Staphylococcus aureus infection.
Iron overload reprogramming lipid metabolism through the IRP1-SCAP axis in fibroblast-like synoviocytes aggravates bone destruction in rheumatoid arthritis.
Nobiletin and polydatin synergistically alleviate triple-negative breast cancer liver metastasis via suppressing ECM1a-mediated fatty acid biosynthesis.
NPM3 functions as a lactyltransferase to promote necroptosis in male diabetic cardiomyopathy mice models via FASN transcription modulation.
Integrated Multiomic Analysis Provides New Insights into the Adipogenic Differentiation of Porcine Adipocytes and Reveals the Regulatory Role of ACACA in Adipogenesis.
Fermented Black Soybean and Dehulled Adlay Improve Metabolic Syndrome via AMPK-SIRT1 Activation and Gut Microbiota Modulation.
Ski2-like helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responses.
FASN inactivation-induced progranulin (GRN) expression promotes lysosome-dependent cell death to suppress leukemogenesis.
METTL3 stabilizes FASN mRNA by mediating m(6)A modification to promote malignant progression of diffuse large B-cell lymphoma.
The Porcine Colitis Model Recapitulates the Visceral Adipose Metabolic Reprogramming of Human Ulcerative Colitis.
cGAS-STING signaling pathway promotes ischemic kidney injury by regulating HK3-mediated lipid accumulation.
Caveolin-1 deficiency exacerbates liver fibrosis by driving lipid metabolic reprogramming in hepatic stellate cells via DRP1-mediated mitochondrial fission.
Monascus pilosus SWM-008-Fermented Red Mold Rice and Its Monascinol Ameliorate Non-Alcoholic Fatty Liver Disease via Activation of the AMPK-ATGL Pathway and Enrichment of Butyrate-Producing Bacteria.
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy.
Gastric bypass surgery improves lipid metabolism and mitochondrial function through the glutamate receptor Grin3a-mediated CaMKKβ/AMPK pathway in a rat model of type 2 diabetes.
The role of FOXO1/PPARγ in atrazine-induced hepatic lipid metabolism disorders.
Narirutin Reprograms Fatty Acid Metabolism and Inhibits Tumorigenesis via Downregulating ADORA3 Expression in Colorectal Cancer.
Targeting aldose reductase in pulmonary fibrosis: Blocking de novo fatty acid synthesis halts pro-fibrotic M2 polarization.
Brusatol ameliorates psoriatic dyslipidemia by targeting IL-1β to restore AMPK-mediated lipid homeostasis.
From rosemary and coffee to bioactive nanovesicles: exploring new frontiers in food functional ingredients.
The UFL1-AKT positive feedback loop promotes breast cancer progression by enhancing lipid synthesis.
Combination of GLP-1 receptor agonist and Akkermansia muciniphila Akk11 reduces adiposity and ameliorates MASLD in T2D mice.
KCNK3 coordinates adipocyte lipid storage and thermogenic shifts via AMPK, modulating a ferroptosis-permissive state.
Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development.
Lysine malonylation regulates human sperm motility.
Characterization of gRNA-dependent and gRNA-independent off-target binding sites of PspCas13b and RfxCas13d in mammalian cells.
c-Myc/GRPEL1 maintains fatty acid synthesis via FASN to support PDAC cell proliferation.
Combinatorial treatment with donafenib and quercetin suppresses lipid metabolism in HepG2 cells by targeting the CREB1/DRP1/SREBP1 axis.
Paeoniflorin Alleviates Metabolic Dysfunction-Associated Steatotic Liver Disease by Inhibiting Hepatic Lipogenesis and Inflammation.
Macrophage-derived IL-6 reprograms lipid metabolism to promote colorectal cancer development through USP14-mediated FASN deubiquitination.
FOXN3 integrates the KU70/KU80/SREBP-1 complex to regulate lipid metabolism in non-alcoholic fatty liver disease.
Erianin inhibits 3T3-L1 adipocyte differentiation through downregulation of CCAAT-enhancer binding protein-α and peroxisome proliferator-activated receptor-γ, lipogenic genes and impairment of mitochondrial respiration.
Diosgenin alleviates hepatic fibrosis via PI3K/Akt/mTOR mediated fatty acid metabolic reprogramming and NF-κB activation.
SREBP1-activated lipid metabolism drives ferroptosis and progression of clear cell renal cell carcinoma.
CLCC1 governs ER bilayer equilibration to maintain lipid homeostasis.
Small extracellular vesicles derived from lipotoxic hepatocytes transport FASN to promote hepatic stellate cell activation.
Dapagliflozin induces renal lipidomic remodeling and systemic metabolic improvement.
Network toxicology and machine learning revealed the association between non-alcoholic fatty liver disease induced by polystyrene nanoplastics.
PPARG Activation of Fatty Acid Metabolism Drives Resistance to Anti-HER2 Therapies in HER2-Positive Breast Cancer.
Rabdosia rubescens Inhibits CYP7A1 Expression and Induces Autophagy to Reduce Alcohol-Induced Liver Damage in Mice.
METTL3/miR-192-5p/SCD1 Axis Regulates Lipid Metabolism to Affect T Cell Differentiation in Asthma.
Rapamycin and Chloroquine Modulate Insulin Resistance and Hepatic Steatosis in a High-Fat/High-Cholesterol Diet-Induced Metabolic Dysfunction-Associated Steatotic Liver Disease Mouse Model.
Integrated Single-Cell and Transcriptome Analysis with Experimental Validation Reveals PANoptosis-Related Gene Signatures in the Immune Microenvironment of Autoimmune Thyroiditis.
Xingxiao Pill Suppressed the Progression of Non-Small Cell Lung Cancer by Targeting SREBP1/FASN-Induced Fatty Acid Biosynthesis via PI3K/AKT/mTOR Signaling Pathway.
FASN promotes the stemness of cancer stem cells and protects colorectal cancer cells from ferroptosis by inhibiting the activation of SREBP2.
Gallic acid mitigates high-fat and high-carbohydrate diet-induced steatohepatitis by modulating the IRF6/PPARγ signaling pathway.
Reversed role of CD36 deficiency in high-fat diet or methionine/choline-deficient diet-induced hepatic steatosis and steatohepatitis.
FOXK2 regulates fatty acid metabolism and promotes cervical cancer progression by activating the mTOR/DRP1 signaling axis.
Matrix stiffness boosts PDAC chemoresistance via SCD1-dependent lipid metabolic reprogramming.
Jianpi Yangzheng Xiaozheng granule induced ferroptosis to suppress gastric cancer progression through reprogramming lipid metabolism via SCD1/Wnt/β-catenin axis.
Knockdown of ACC1 promotes migration and invasion of U251 glioma cells by epigenetically suppressing SDH.
Lipin1-dependent transcriptional inactivation of SREBPs contributes to selinexor sensitivity in multiple myeloma.
CHAF1A Promotes Preadipocyte Differentiation and Contributes to Macrosomia in Gestational Diabetes Mellitus.
Mechanisms of metabolic-associated fatty liver disease induced by 48-week PCB138 exposure and theabrownin intervention.
Proinflammatory polarization of adipose tissue macrophages in cows with subclinical ketosis constitutes a critical driver of adipose tissue remodeling and inflammation.
Klebsiella pneumoniae Induces Ferroptosis and Lactation Dysfunction in Bovine Mastitis via NCOA4-Mediated Ferritinophagy.
Breviscapine regulates lipid metabolism of microglia via the ADORA1/PPARα/ACOX1 pathway to promote spinal cord injury recovery.
Chronic Waterborne Exposure to Polystyrene Microplastics Induces Kupffer Cell Polarization Imbalance and Hepatic Lipid Accumulation.
Triclocarban Disrupts Hepatic Lipid Homeostasis and Promotes Endoplasmic Reticulum Stress in Mice: A Multiomics Investigation.
Peroxisomal metabolism of branched fatty acids regulates energy homeostasis.
TRIM34 inhibits triple-negative breast cancer progression by attenuating fatty acid synthesis via facilitating FASN ubiquitination.
Androgen regulates seasonal changes in triglyceride synthesis through the AR-SREBP1-FASN axis in the scented glands of muskrats (Ondatra zibethicus).
High-Calorie Diet During Pregnancy Leads to Muscular Fibrosis and Neuromuscular Damage in Offspring Mice.
Mechanism by which CAP regulates the "cold-heat" balance in osteosarcoma model mice: an integrative study of metabolomics, transcriptomics, and network pharmacology.
FASN inhibits ferroptosis in breast cancer via USP5 palmitoylation-dependent regulation of GPX4 deubiquitination.
Maternal exposure to high level of ursodeoxycholic acid during pregnancy promotes hepatic lipid deposition in the offspring by reducing the methylation level of Fasn gene.
Fatty acid metabolism-related signature suggests an oncogenic role of FASN in cervical cancer.
Stabilization of FASN by USP5-mediated deubiquitination promotes hepatocellular carcinoma progression.
Divergent Regulation of Mammary Lipogenesis by trans-10, cis-12 and cis-9, trans-11 CLA Isomers Is Determined by Receptor-Specific Signaling.
Unveiling plumbagin as a novel metabolic modulator to suppress ACC1-mediated de novo lipogenesis in non-small cell lung cancer.
The cyclic peptide mallotumide A inhibits colon and breast cancer cell growth and motility by targeting cellular respiration and lipogenesis.
ARMC10 Drives Glioblastoma Progression Through Activating Notch Pathway.
FTO aggravates podocyte injury and diabetic nephropathy progression via m6A-dependent stabilization of ACC1 mRNA and promoting fatty acid metabolism.
Steam explosion modified pea peptides alleviates hepatosteatosis by regulating lipid metabolism pathways and promoting autophagy.
Insight into perfluorooctanoic acid-induced impairment of mouse embryo implantation via single-cell RNA-seq.
Baicalin mitigates alcoholic-associated liver disease via SOCS1-driven reprogramming of macrophages.
Integrated prognostic assessment of apoptosis and chemotherapy related gene in bladder cancer: a prognostic signature.
Dietary coconut oil lowered circulating fetuin-A levels and hepatic expression of fetuin-A in KK/TaJcl mice.
Inhibition of STRA6 suppresses NSCLC growth via blocking STAT3/SREBP-1c axis-mediated lipogenesis.
The effects of citalopram and sertraline on adipogenesis and lipogenesis in 3T3-L1 cells.
FASN promotes lipid metabolism and progression in colorectal cancer via the SP1/PLA2G4B axis.
TSPAN31 Activates Fatty Acid Metabolism and PI3K/AKT Pathway to Promote Tumor Progression in Breast Cancer.
Exogenous hydrogen sulfide improves non-alcoholic fatty liver disease by inhibiting endoplasmic reticulum stress/NLRP3 inflammasome pathway.
CD36 molecule and AMP-activated protein kinase signaling drive docosahexaenoic acid-induced lipid remodeling in goat mammary epithelial cells.
Rotenone adaptation promotes migration and invasion of p53-wild-type colon cancer through lipid metabolism.
Ginsenoside Rk1 Ameliorates Non-Alcoholic Fatty Liver Disease by Targeting CD36 to Modulate the AMPK Signaling Pathway.
Hawthorn total flavonoids ameliorate hyperlipidemia through AMPK/SREBP1-c and PPARα/PGC-1α/CPT-1A pathway activation and gut microbiota modulation.
Dual-omics analysis of transcriptome and translatome unveils lycopene-induced triglyceride accumulation mechanisms in muscle cells.
Antrodia cinnamomea Extract Attenuates Obesity by Targeting Adipogenic Pathways and Gut Dysbiosis in High-Fat Diet-Fed Mice.
Metal-organic framework nanomaterials alter cellular metabolism in bladder cancer.
Senkyunolide I suppresses hepatic stellate cell activation and liver fibrosis by reprogramming VDR-dependent fatty acid metabolism.
Thermo-responsive nano-hydrogel-based delivery of Saikosaponin a to enhance anti-PD-1 therapy in osteosarcoma.
Integratomic investigation to assess the liver lipidomic and antiinflammatory activity of lupin protein hydrolysate.
The Ski2 helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responses.
The N-terminal domain of gasdermin D induces liver fibrosis by reprogrammed lipid metabolism.
Hsp90α promotes lipogenesis by stabilizing FASN and promoting FASN transcription via LXRα in hepatocellular carcinoma.
Foxk2 Enhances Adipogenic Differentiation by Relying on the Transcriptional Activation of Peroxisome Proliferator-Activated Receptor Gamma.
Abnormal ac4C modification in metabolic dysfunction associated steatotic liver cells.
Diosgenin attenuates nonalcoholic fatty liver disease through mTOR-mediated inhibition of lipid accumulation and inflammation.
Fatty Acid Esterification of Octacosanol Attenuates Triglyceride and Cholesterol Synthesis in Mice.
Integrated network pharmacology, metabolomics and molecular docking analysis to reveal the mechanisms of quercetin in the treatment of hyperlipidemia.
Lactamase β reprograms lipid metabolism to inhibit the progression of endometrial cancer through attenuating MDM2-mediated p53 ubiquitination and degradation.
Small molecule-driven LKB1 deacetylation is responsible for the inhibition of hepatic lipid response in NAFLD.
Melittin suppresses ovarian cancer growth by regulating SREBP1-mediated lipid metabolism.
Natural molecule isoliquiritigenin mitigates MASH and liver fibrosis in mice by promoting autophagy through the PI3K/Akt signaling pathway.
Mechanism of O-GlcNAcylation regulating liver lipid synthesis in mice through FASN.
Liver ALKBH5 regulates glucose and lipid homeostasis independently through GCGR and mTORC1 signaling.
Lipogenic enzyme FASN promotes mutant p53 accumulation and gain-of-function through palmitoylation.
Isoliquiritigenin Ameliorates High-Fat Diet-Induced Obesity in Mice by Activating Brown Adipose Tissue.
Vitisin A Outperforms Cyanidin-3-O-Glucoside in Triglyceride Reduction by Modulating Hepatic Lipogenesis and Fatty Acid β-Oxidation.
Ferulic acid from Angelica sinensis (Oliv.) Diels ameliorates lipid metabolism in alcoholic liver disease via AMPK/ACC and PI3K/AKT pathways.
miRNA-novel-216 regulated fatty acid composition and progesterone synthesis in goat granulosa cells by targeting the TPD52.
IMUP promotes fatty acid metabolism and lung cancer progression by regulating TGF-β/SMAD3 signaling pathway.
TsR-0072 inhibits colorectal cancer progression through modulating lipid and vitamin D(3) metabolic reprogramming and inactivating the Wnt/β-catenin signalling pathway.
FASN regulates CSE-induced apoptosis, oxidative stress and mitochondrial damage in type 2 alveolar epithelial cells by regulating NRF2 expression and nuclear translocation.
Tryptophan derivatives as non-invasive diagnostic indicators for obesity-related MASLD in children and adolescents.
Gut-liver axis mechanisms of Hippophae rhamnoides L. in non-alcoholic fatty liver disease prevention.
Discovery of highly potent marine-derived compound Penicolinate H reveals SREBP-1 mediated lipogenesis as a druggable vulnerability in gastric cancer.
Fatty acid synthase may facilitate the trafficking of bovine alpha herpesvirus 1 out of the Golgi apparatus, potentially promoting viral infection.
Integrated analysis of lactylation modification and proteomics revealed potential epigenetic regulation in intramuscular fat deposition of Xidu black pigs.
Early life exposure to environmental levels of PCB138 induces lipid metabolism disorders through activating aryl hydrocarbon receptor in female mice.
EGCG and Taurine Synergistically Ameliorate Lipid Metabolism Disorder by Modulating Gut Microbiota and PPARα/FAS Signaling Pathway.
CircZFR/YTHDF3 axis drives lymph node metastasis in cervical cancer via FASN translation.
VDR Decrease Enhances the Efficacy of 1,25-Dihydroxyvitamin D3 Inhibiting Gefitinib Resistance by Regulating EGFR/FASN Loop in NSCLC Cells.
MOSPD1 facilitates fatty acid metabolism and gastric cancer progression by promoting the MAPK pathway.
IRX5 Promoted SREBP1-Mediated de Novo Fatty Acid Synthesis via HMGN4 in Hepatocellular Carcinoma.
Accumulation of Damaging Lipids in the Arf1-Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia.
LIMA1 O-GlcNAcylation Promotes Hepatic Lipid Deposition through Inducing β-catenin-Regulated FASn Expression in Metabolic Dysfunction-Associated Steatotic Liver Disease.
High expression of myeloperoxidase may be related to the occurrence of urethral fistula in hypospadias patients after tubularized-incised plate urethroplasty repair.
IGF2BP3/ESM1/KLF10/BECN1 positive feedback loop: a novel therapeutic target in ovarian cancer via lipid metabolism reprogramming.
Darolutamide-mediated phospholipid remodeling induces ferroptosis through the SREBP1-FASN axis in prostate cancer.
Protective effects of small RNAs encapsulated in Artemisia Capillaris-derived exosomes against non-alcoholic fatty liver disease.
Development and validation of a glycolysis-associated gene signature for predicting the prognosis, immune landscape, and drug sensitivity in bladder cancer.
Traditional Chinese Medicine formula Dai-Zong-Fang alleviating hepatic steatosis in db/db mice via gut microbiota modulation.
Integrative proteogenomic profiling of high-risk prostate cancer samples from Chinese patients indicates metabolic vulnerabilities and diagnostic biomarkers.
The developmental pattern related to fatty acid uptake and oxidation in the yolk sac membrane and jejunum during embryogenesis in Muscovy duck.
Effects of Mao tea from Nankun Mountain on nonalcoholic fatty liver disease in mice.
Clinopodium gracile Alleviates Metabolic Dysfunction-Associated Steatotic Liver Disease by Upregulating Peroxisome Proliferator-Activated Receptor α and Inhibiting Mitochondrial Oxidative Damage.
Two novel compounds inhibit Flavivirus infection in vitro and in vivo by targeting lipid metabolism.
Novel Dual PPAR δ/γ Partial Agonist Induces Hepatic Lipid Accumulation through Direct Binding and Inhibition of AKT1 Phosphorylation, Mediating CD36 Upregulation.
Compound heterozygous RYR1-RM mouse model reveals disease pathomechanisms and muscle adaptations to promote postnatal survival.
Exploring the Effects of Whole Food-Based Dragon Fruit on Metabolic Disorders in High-Fat Diet-Induced Mice.
A Mix of Probiotic Strains Prevents Hepatic Steatosis, and Improves Oxidative Stress Status and Gut Microbiota Composition in Obese Mice.
Metformin suppresses metabolic dysfunction-associated fatty liver disease by ferroptosis and apoptosis via activation of oxidative stress.
Transcriptional Regulation of De Novo Lipogenesis by SIX1 in Liver Cancer Cells.
NAT10 promotes liver lipogenesis in mouse through N4-acetylcytidine modification of Srebf1 and Scap mRNA.
Probiotic-fermented tomato with hepatic lipid metabolism modulation effects: analysis of physicochemical properties, bioactivities, and potential bioactive compounds.
Effect of LncRNA LOC106505926 on myogenesis and Lipogenesis of porcine primary cells.
Ficolin 3 promotes ferroptosis in HCC by downregulating IR/SREBP axis-mediated MUFA synthesis.
DPP3 promotes breast cancer tumorigenesis by stabilizing FASN and promoting lipid synthesis.
SIRT2-mediated deacetylation of ACLY promotes the progression of oesophageal squamous cell carcinoma.
GSTM3 enhances radiosensitivity of nasopharyngeal carcinoma by promoting radiation-induced ferroptosis through USP14/FASN axis and GPX4.
Transcriptional and metabolic effects of aspartate-glutamate carrier isoform 1 (AGC1) downregulation in mouse oligodendrocyte precursor cells (OPCs).
Lipid droplet accumulation in Wdr45-deficient cells caused by impairment of chaperone-mediated autophagic degradation of Fasn.
Integrating transcriptomics and network pharmacology to reveal the mechanisms of total Rhizoma Coptidis alkaloids against nonalcoholic steatohepatitis.
Mechanistic of AMPK/ACC2 regulating myoblast differentiation by fatty acid oxidation of goat.
Effects of endurance training under calorie restriction on energy substrate metabolism in mouse skeletal muscle and liver.
ROS Induced by Aphrocallistes vastus Lectin Enhance Oncolytic Vaccinia Virus Replication and Induce Apoptosis in Hepatocellular Carcinoma Cells.
Bruceine A alleviates alcoholic liver disease by inhibiting AIM2 inflammasome activation via activating FXR.
Lactobacillus rhamnosus 069 and Lactobacillus brevis 031: Unraveling Strain-Specific Pathways for Modulating Lipid Metabolism and Attenuating High-Fat-Diet-Induced Obesity in Mice.
Insulin receptor isoform B is required for efficient proinsulin processing in pancreatic β cells.
The effect and mechanism of combined exposure of MC-LR and NaNO(2) on liver lipid metabolism.
Time-restricted feeding ameliorates non-alcoholic fatty liver disease through modulating hepatic nicotinamide metabolism via gut microbiota remodeling.
PITPNC1 Suppress CD8(+) T cell immune function and promote radioresistance in rectal cancer by modulating FASN/CD155.
Prepared Radix Polygoni Multiflori and emodin alleviate lipid droplet accumulation in nonalcoholic fatty liver disease through MAPK signaling pathway inhibition.
LncRNA Gm28382 promotes lipogenesis by interacting with miR-326-3p to regulate ChREBP signaling pathway in NAFLD.
TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis.
A nanoemulsion targeting adipose hypertrophy and hyperplasia shows anti-obesity efficiency in female mice.
Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease.
Metabolic reprogramming based on RNA sequencing of gemcitabine-resistant cells reveals the FASN gene as a therapeutic for bladder cancer.
Acetyl-CoA synthetase 2 promotes diabetic renal tubular injury in mice by rewiring fatty acid metabolism through SIRT1/ChREBP pathway.
Hypoxia induced cell dormancy of salivary adenoid cystic carcinoma through miR-922/DEC2 axis.
Farnesoid X receptor overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in nonalcoholic fatty liver disease.
FXR overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in alcoholic liver disease.
Ginsenoside Rg5 inhibits lipid accumulation and hepatocyte apoptosis via the Notch1 signaling pathway in NASH mice.
Metastatic effects of perfluorooctanoic acid (PFOA) on Drosophila melanogaster with metabolic reprogramming and dysrhythmia in a multigenerational exposure scenario.
Topical rhubarb charcoal-crosslinked chitosan/silk fibroin sponge scaffold for the repair of diabetic ulcers improves hepatic lipid deposition in db/db mice via the AMPK signalling pathway.
SHMT2 reduces fatty liver but is necessary for liver inflammation and fibrosis in mice.
Geniposide alleviates heart failure with preserved ejection fraction in mice by regulating cardiac oxidative stress via MMP2/SIRT1/GSK3β pathway.
Spatial multi-omics characterizes GPR35-relevant lipid metabolism signatures across liver zonation in MASLD.
Pharmacological inhibition of SREBP1 suppresses pancreatic cancer growth via inducing GPX4-mediated ferroptosis.
FASN contributes to ADM resistance of diffuse large B-cell lymphoma by inhibiting ferroptosis via nf-κB/STAT3/GPX4 axis.
Lipid droplet formation induced by icaritin derivative IC2 promotes a combination strategy for cancer therapy.
Neutrophil extracellular traps in rheumatoid arthritis: Activating fibroblast-like synoviocytes via ATP citrate lyase.
ZDHHC20 mediated S-palmitoylation of fatty acid synthase (FASN) promotes hepatocarcinogenesis.
Hepatoprotective effect of dietary pterostilbene against high-fat-diet-induced lipid accumulation exacerbated by chronic jet lag via SIRT1 and SIRT3 activation.
C9orf72 controls hepatic lipid metabolism by regulating SREBP1 transport.
miR-218-5p promotes hepatic lipogenesis through targeting Elovl5 in non-alcoholic fatty liver disease.
CD9 Counteracts Liver Steatosis and Mediates GCGR Agonist Hepatic Effects.
Berberine alleviates high-energy and low-protein diet-induced fatty liver hemorrhagic syndrome in laying hens: insights from microbiome and metabolomics.
Regulatory effect of β-glucan secreted by Rhizobium pusense on triglyceride metabolism and their relationships with the modulation of intestinal microbiota in mice fed a high-fat diet.
circNDUFA13 stimulates adipogenesis of bone marrow-derived mesenchymal stem cells via interaction with STAT3.
Lipid synthesis, triggered by PPARγ T166 dephosphorylation, sustains reparative function of macrophages during tissue repair.
Modulatory Effects of Lactobacillus paracasei-Fermented Turmeric on Metabolic Dysregulation and Gut Microbiota in High-Fat Diet-Induced Obesity in Mice.
Voluntary Wheel Running Reduces Cardiometabolic Risks in Female Offspring Exposed to Lifelong High-Fat, High-Sucrose Diet.
Rutin ameliorated lipid metabolism dysfunction of diabetic NAFLD via AMPK/SREBP1 pathway.
Sodium butyrate alleviates free fatty acid-induced steatosis in primary chicken hepatocytes via the AMPK/PPARα pathway.
PPARγ alleviates preeclampsia development by regulating lipid metabolism and ferroptosis.
Hepatocyte-Specific PEX16 Abrogation in Mice Leads to Hepatocyte Proliferation, Alteration of Hepatic Lipid Metabolism, and Resistance to High-Fat Diet (HFD)-Induced Hepatic Steatosis and Obesity.
Herpetrione, a New Type of PPARα Ligand as a Therapeutic Strategy Against Nonalcoholic Steatohepatitis.
Differences in histomorphology and expression of key lipid regulated genes of four adipose tissues from Tibetan pigs.
Sphingomyelin synthase-related protein SMSr is a phosphatidylethanolamine phospholipase C that promotes nonalcoholic fatty liver disease.
miR-32-5p induces hepatic steatosis and hyperlipidemia by triggering de novo lipogenesis.
Metabolic characteristics of voriconazole - Induced liver injury in rats.
BCKDHA contributes to melanoma progression by promoting the expressions of lipogenic enzymes FASN and ACLY.
Long-term and liver-selected ginsenoside C-K nanoparticles retard NAFLD progression by restoring lipid homeostasis.
Cullin-associated and neddylation-dissociated 1 regulate reprogramming of lipid metabolism through SKP1-Cullin-1-F-box(FBXO11) -mediated heterogeneous nuclear ribonucleoprotein A2/B1 ubiquitination and promote hepatocellular carcinoma.
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
Sex differences in FASN protein concentrations in urinary exosomes related to serum triglycerides levels in healthy adults.
E3 ubiquitin ligase Siah1 aggravates NAFLD through Scp2 ubiquitination.
High dietary fructose promotes hepatocellular carcinoma progression by enhancing O-GlcNAcylation via microbiota-derived acetate.
A bacteria-derived tetramerized protein ameliorates nonalcoholic steatohepatitis in mice via binding and relocating acetyl-coA carboxylase.
Resensitizing Paclitaxel-Resistant Ovarian Cancer via Targeting Lipid Metabolism Key Enzymes CPT1A, SCD and FASN.
MiR-337-3p improves metabolic-associated fatty liver disease through regulation of glycolipid metabolism.
TRPV4 enhances the synthesis of fatty acids to drive the progression of ovarian cancer through the calcium-mTORC1/SREBP1 signaling pathway.
Inhibiting Phosphatidylcholine Remodeling in Adipose Tissue Increases Insulin Sensitivity.
Enhancement of PPARα-Inhibited Leucine Metabolism-Stimulated β-Casein Synthesis and Fatty Acid Synthesis in Primary Bovine Mammary Epithelial Cells.
TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN.
Dedifferentiated fat cells administration ameliorates abnormal expressions of fatty acids metabolism-related protein expressions and intestinal tissue damage in experimental necrotizing enterocolitis.
Insoluble Dietary Fiber from Soybean Residue (Okara) Exerts Anti-Obesity Effects by Promoting Hepatic Mitochondrial Fatty Acid Oxidation.
Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR-7/m-TOR/SREBP1 pathway on prostate cancer.
Developmental changes in lipid and fatty acid metabolism and the inhibition by in ovo feeding oleic acid in Muscovy duck embryogenesis.
Gamma-Muricholic Acid Inhibits Nonalcoholic Steatohepatitis: Abolishment of Steatosis-Dependent Peroxidative Impairment by FXR/SHP/LXRα/FASN Signaling.
Docosahexaenoic Acid Alters Lipid Metabolism Processes via H3K9ac Epigenetic Modification in Dairy Goat.
Differential Inhibition of Anaplerotic Pyruvate Carboxylation and Glutaminolysis-Fueled Anabolism Underlies Distinct Toxicity of Selenium Agents in Human Lung Cancer.
Long noncoding RNAs with peptide-encoding potential identified in esophageal squamous cell carcinoma: KDM4A-AS1-encoded peptide weakens cancer cell viability and migratory capacity.
Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1/2-PPARγ-Cd36 pathway.
Imbalance in ALR ubiquitination accelerates the progression of nonalcoholic steatohepatitis to hepatocellular carcinoma.
TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability.
Enhanced De Novo Lipid Synthesis Mediated by FASN Induces Chemoresistance in Colorectal Cancer.
LncRNA-TBP mediates TATA-binding protein recruitment to regulate myogenesis and induce slow-twitch myofibers.
CircRNA MBOAT2 promotes intrahepatic cholangiocarcinoma progression and lipid metabolism reprogramming by stabilizing PTBP1 to facilitate FASN mRNA cytoplasmic export.
Protein kinase C epsilon promotes de novo lipogenesis and tumor growth in prostate cancer cells by regulating the phosphorylation and nuclear translocation of pyruvate kinase isoform M2.
Knockout of ICAT in Adipose Tissue Alleviates Fibro-inflammation in Obese Mice.
Docosahexaenoic acid reverses PD-L1-mediated immune suppression by accelerating its ubiquitin-proteasome degradation.
L-Theanine regulates lipid metabolism by modulating gut microbiota and bile acid metabolism.
Vitamin D Receptor Activation Attenuates Olanzapine-Induced Dyslipidemia in Mice Through Alleviating Hepatic Endoplasmic Reticulum Stress.
Foxk1 stimulates adipogenic differentiation via a peroxisome proliferator-activated receptor gamma 2-dependent mechanism.
Expression profile of FASN gene and association of its polymorphisms with intramuscular fat content in Hu sheep.
F6P/G6P-mediated ChREBP activation promotes the insulin resistance-driven hepatic lipid deposition in zebrafish.
Lonicerae flos polysaccharides improve nonalcoholic fatty liver disease by activating the adenosine 5'-monophosphate-activated protein kinase pathway and reshaping gut microbiota.
Senescence-associated 13-HODE production promotes age-related liver steatosis by directly inhibiting catalase activity.
LncHLEF promotes hepatic lipid synthesis through miR-2188-3p/GATA6 axis and encoding peptides and enhances intramuscular fat deposition via exosome.
Therapeutic protein PAK restrains the progression of triple negative breast cancer through degrading SREBP-1 mRNA.
α-Lactalbumin Peptide Asp-Gln-Trp Ameliorates Hepatic Steatosis and Oxidative Stress in Free Fatty Acids-Treated HepG2 Cells and High-Fat Diet-Induced NAFLD Mice by Activating the PPARα Pathway.
Decreased Imiquimod-Induced Psoriasis-Like Skin Inflammation in a Novel Mvd(F250S/+) Knock-In Mouse Model.
Integrated multi-omics analyses reveal Jorunnamycin A as a novel suppressor for muscle-invasive bladder cancer by targeting FASN and TOP1.
Cordycepin reprogramming lipid metabolism to block metastasis and EMT via ERO1A/mTOR/SREBP1 axis in cholangiocarcinoma.
Epiberberine regulates lipid synthesis through SHP (NR0B2) to improve non-alcoholic steatohepatitis.
Protopanaxadiol ameliorates NAFLD by regulating hepatocyte lipid metabolism through AMPK/SIRT1 signaling pathway.
Tandem mass tag-based quantitative proteomics analysis reveals the effects of the α-lactalbumin peptides GINY and DQW on lipid deposition and oxidative stress in HepG2 cells.
A UPLC-Q-TOF/MS and network pharmacology method to explore the mechanism of Anhua fuzhuan tea intervention in nonalcoholic fatty liver disease.
DAXX drives de novo lipogenesis and contributes to tumorigenesis.
MiR-328-5p inhibits the adipogenic differentiation of hMSCs by targeting fatty acid synthase.
Profile analysis and functional modeling identify circular RNAs in nonalcoholic fatty liver disease as regulators of hepatic lipid metabolism.
D-Mannose Regulates Hepatocyte Lipid Metabolism via PI3K/Akt/mTOR Signaling Pathway and Ameliorates Hepatic Steatosis in Alcoholic Liver Disease.
Effects of Poria cocos extract on metabolic dysfunction-associated fatty liver disease via the FXR/PPARα-SREBPs pathway.
PRMT5 confers lipid metabolism reprogramming, tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours.
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.
A therapeutic DC vaccine with maintained immunological activity exhibits robust anti-tumor efficacy.
Metabolic Syndrome Ameliorated by 4-Methylesculetin by Reducing Hepatic Lipid Accumulation.
Super-enhancer-associated INSM2 regulates lipid metabolism by modulating mTOR signaling pathway in neuroblastoma.
The role of hepatic Surf4 in lipoprotein metabolism and the development of atherosclerosis in apoE(-/-) mice.
Cerulenin suppresses ErbB2-overexpressing breast cancer by targeting ErbB2/PKM2 pathway.
Derepression of the USP22-FASN axis by p53 loss under oxidative stress drives lipogenesis and tumorigenesis.
circPRKAA1 activates a Ku80/Ku70/SREBP-1 axis driving de novo fatty acid synthesis in cancer cells.
Obesity promotes lipid accumulation in lymph node metastasis of gastric cancer: a retrospective case‒control study.
FASN promotes lymph node metastasis in cervical cancer via cholesterol reprogramming and lymphangiogenesis.
Dietary L-arginine supplementation of tilapia (Oreochromis niloticus) alters the microbial population and activates intestinal fatty acid oxidation.
Effects of maternal feed intake restriction on the blood parameters, fatty acid profile and lipogenetic genes expression of perirenal fat in offspring kids.
Psoralen Suppresses Lipid Deposition by Alleviating Insulin Resistance and Promoting Autophagy in Oleate-Induced L02 Cells.
Novel phosphanegold(I) thiolate complexes suppress de novo lipid synthesis in human lung cancer.
CRISPR/Cas9-Induced Knockout of miR-24 Reduces Cholesterol and Monounsaturated Fatty Acid Content in Primary Goat Mammary Epithelial Cells.
Quantitative proteomic analysis of Bi Zhong Xiao decoction against collagen-induced arthritis rats in the early and late stages.
Scutellarin ameliorates hepatic lipid accumulation by enhancing autophagy and suppressing IRE1α/XBP1 pathway.
MicroRNA-377-3p inhibits hepatocellular carcinoma growth and metastasis through negative regulation of CPT1C-mediated fatty acid oxidation.
Ginsenoside CK ameliorates hepatic lipid accumulation via activating the LKB1/AMPK pathway in vitro and in vivo.
Protein C receptor maintains cancer stem cell properties via activating lipid synthesis in nasopharyngeal carcinoma.
TiO(2) nanosheets promote the transformation of vascular smooth muscle cells into foam cells in vitro and in vivo through the up-regulation of nuclear factor kappa B subunit 2.
Polyphyllin I improves myocardial damage in coronary artery disease via modulating lipid metabolism and myocardial apoptosis.
Di-2-ethylhexyl phthalate-induced miR-155-5p promoted lipid metabolism via inhibiting cAMP/PKA signaling pathway in human trophoblastic HTR-8/Svneo cells.
Loss of Mature Lamin A/C Triggers a Shift in Intracellular Metabolic Homeostasis via AMPKα Activation.
Microalgae oil from Schizochytrium sp. alleviates obesity and modulates gut microbiota in high-fat diet-fed mice.
Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion.
MiR-103-3p promotes hepatic steatosis to aggravate nonalcoholic fatty liver disease by targeting of ACOX1.
Salvia-Nelumbinis naturalis improves lipid metabolism of NAFLD by regulating the SIRT1/AMPK signaling pathway.
Functionalized gadofullerene ameliorates impaired glycolipid metabolism in type 2 diabetic mice.
Long noncoding RNA ZFP36L2-AS functions as a metabolic modulator to regulate muscle development.
RNF8 up-regulates AR/ARV7 action to contribute to advanced prostate cancer progression.
LYAR Promotes Colorectal Cancer Progression by Upregulating FSCN1 Expression and Fatty Acid Metabolism.
The Mutual Inhibition of FoxO1 and SREBP-1c Regulated the Progression of Hepatoblastoma by Regulating Fatty Acid Metabolism.
PRPF6 promotes androgen receptor/androgen receptor-variant 7 actions in castration-resistant prostate cancer cells.
SOAT1 Promotes Gastric Cancer Lymph Node Metastasis Through Lipid Synthesis.
High-Salt Attenuates the Efficacy of Dapagliflozin in Tubular Protection by Impairing Fatty Acid Metabolism in Diabetic Kidney Disease.
Pterostilbene attenuates RIPK3-dependent hepatocyte necroptosis in alcoholic liver disease via SIRT2-mediated NFATc4 deacetylation.
Deficiency of intestinal Bmal1 prevents obesity induced by high-fat feeding.
Novel SREBP1 inhibitor cinobufotalin suppresses proliferation of hepatocellular carcinoma by targeting lipogenesis.
Comprehensive multi-omics approaches reveal the hepatotoxic mechanism of perfluorohexanoic acid (PFHxA) in mice.
Exercise improves lipid metabolism disorders induced by high-fat diet in a SESN2/JNK-independent manner.
Changes of lipid profiles in human umbilical vein endothelial cells exposed to zirconia nanoparticles with or without the presence of free fatty acids.
Lipid metabolism regulator human hydroxysteroid dehydrogenase-like 2 (HSDL2) modulates cervical cancer cell proliferation and metastasis.
Apple polyphenol extract alleviates lipid accumulation in free-fatty-acid-exposed HepG2 cells via activating autophagy mediated by SIRT1/AMPK signaling.
Inhibition of lipogenesis and induction of apoptosis by valproic acid in prostate cancer cells via the C/EBPα/SREBP-1 pathway.
Gu-Ben-Fang-Xiao decoction modulates lipid metabolism by activating the AMPK pathway in asthma remission.
BMP4-mediated browning of perivascular adipose tissue governs an anti-inflammatory program and prevents atherosclerosis.
Comparison of multi-walled carbon nanotubes and halloysite nanotubes on lipid profiles in human umbilical vein endothelial cells.
Disrupted glucose homeostasis and skeletal-muscle-specific glucose uptake in an exocyst knockout mouse model.
Transcriptomic analysis suggested the involvement of impaired lipid droplet biogenesis in graphene oxide-induced cytotoxicity in human umbilical vein endothelial cells.
Dexmedetomidine ameliorates high-fat diet-induced nonalcoholic fatty liver disease by targeting SCD1 in obesity mice.
A small molecule targeting ALOX12-ACC1 ameliorates nonalcoholic steatohepatitis in mice and macaques.
TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis.
Betaine prevented high-fat diet-induced NAFLD by regulating the FGF10/AMPK signaling pathway in ApoE(-/-) mice.
Four sesquiterpene glycosides from loquat (Eriobotrya japonica) leaf ameliorates palmitic acid-induced insulin resistance and lipid accumulation in HepG2 Cells via AMPK signaling pathway.
Mogroside V Protects against Hepatic Steatosis in Mice on a High-Fat Diet and LO2 Cells Treated with Free Fatty Acids via AMPK Activation.
LncRNA DNAJC3-AS1 Regulates Fatty Acid Synthase via the EGFR Pathway to Promote the Progression of Colorectal Cancer.
L-Theanine affects intestinal mucosal immunity by regulating short-chain fatty acid metabolism under dietary fiber feeding.
Disruption of Plin5 degradation by CMA causes lipid homeostasis imbalance in NAFLD.
Fatty acid synthase contributes to epithelial-mesenchymal transition and invasion of salivary adenoid cystic carcinoma through PRRX1/Wnt/β-catenin pathway.
Effect and mechanism of ginsenoside Rg1-regulating hepatic steatosis in HepG2 cells induced by free fatty acid.
Modulation of SIRT1-mediated signaling cascades in the liver contributes to the amelioration of nonalcoholic steatohepatitis in high fat fed middle-aged LDL receptor knockout mice by dihydromyricetin.
Dlgap1 negatively regulates browning of white fat cells through effects on cell proliferation and apoptosis.
The lncRNA Gm15622 stimulates SREBP-1c expression and hepatic lipid accumulation by sponging the miR-742-3p in mice.
Association between different levels of lipid metabolism‑related enzymes and fatty acid synthase in Wilms' tumor.
Effects of di (2-ethylhexyl) phthalate and high-fat diet on lipid metabolism in rats by JAK2/STAT5.
Dihydroartemisinin inhibits endothelial cell tube formation by suppression of the STAT3 signaling pathway.
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
Responses of intestinal morphology and function in offspring to heat stress in primiparous sows during late gestation.
Identification of aberrantly methylated differentially expressed genes in prostate carcinoma using integrated bioinformatics.
Adenovirus-mediated expression of SIK1 improves hepatic glucose and lipid metabolism in type 2 diabetes mellitus rats.
Downregulation of PDK4 Increases Lipogenesis and Associates with Poor Prognosis in Hepatocellular Carcinoma.
A Novel Regulatory Circuit "C/EBPα/miR-20a-5p/TOB2" Regulates Adipogenesis and Lipogenesis.
Emodin Induced SREBP1-Dependent and SREBP1-Independent Apoptosis in Hepatocellular Carcinoma Cells.
Sorafenib kills liver cancer cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids via the ATP-AMPK-mTOR-SREBP1 signaling pathway.
Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1.
The metabolic regulator small heterodimer partner contributes to the glucose and lipid homeostasis abnormalities induced by hepatitis C virus infection.
Hepatitis C virus nonstructural protein 5A perturbs lipid metabolism by modulating AMPK/SREBP-1c signaling.
Mono-2-ethylhexyl phthalate (MEHP) promoted lipid accumulation via JAK2/STAT5 and aggravated oxidative stress in BRL-3A cells.
Inhibition of fatty acid synthesis arrests colorectal neoplasm growth and metastasis: Anti-cancer therapeutical effects of natural cyclopeptide RA-XII.
Di (2-ethylhexyl) phthalate Disorders Lipid Metabolism via TYK2/STAT1 and Autophagy in Rats.
Mono-2-ethylhexyl phthalate induces the expression of genes involved in fatty acid synthesis in HepG2 cells.
Effect of selenium nanoparticles against abnormal fatty acid metabolism induced by hexavalent chromium in chicken's liver.
Lingguizhugan decoction attenuates diet-induced obesity and hepatosteatosis via gut microbiota.
Multi-walled carbon nanotubes promoted lipid accumulation in human aortic smooth muscle cells.
Cancer‑associated adipocytes exhibit distinct phenotypes and facilitate tumor progression in pancreatic cancer.
Porphyromonas gingivalis Promotes 4-Nitroquinoline-1-Oxide-Induced Oral Carcinogenesis With an Alteration of Fatty Acid Metabolism.
Brg1 regulates pro-lipogenic transcription by modulating SREBP activity in hepatocytes.
RNA-binding proteins and heat-shock protein 90 are constituents of the cytoplasmic capping enzyme interactome.
Inhibition of androgen receptor transactivation function by adenovirus type 12 E1A undermines prostate cancer cell survival.
Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues.
Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice.
Effect of Dibutyltin Dilaurate on Triglyceride Metabolism through the Inhibition of the mTOR Pathway in Human HL7702 Liver Cells.
Adipose-specific lipin1 overexpression in mice protects against alcohol-induced liver injury.
Effects of calycosin against high-fat diet-induced nonalcoholic fatty liver disease in mice.
GLP-1/GLP-1R Signaling in Regulation of Adipocyte Differentiation and Lipogenesis.
Lack of β, β-carotene-9', 10'-oxygenase 2 leads to hepatic mitochondrial dysfunction and cellular oxidative stress in mice.
Embelin attenuates adipogenesis and lipogenesis through activating canonical Wnt signaling and inhibits high-fat diet-induced obesity.
Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission.
Mitochondrial toxicity of perfluorooctane sulfonate in mouse embryonic stem cell-derived cardiomyocytes.
Alisol B 23-acetate protects against non-alcoholic steatohepatitis in mice via farnesoid X receptor activation.
Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin.
B7-H3 regulates lipid metabolism of lung cancer through SREBP1-mediated expression of FASN.
Calycosin attenuates triglyceride accumulation and hepatic fibrosis in murine model of non-alcoholic steatohepatitis via activating farnesoid X receptor.
Formaldehyde alters triglyceride synthesis and very low-density lipoprotein secretion in a time-dependent manner.
Impact of FHIT loss on the translation of cancer-associated mRNAs.
Neurosecretory protein GL stimulates food intake, de novo lipogenesis, and onset of obesity.
The Effect of Growth Hormone on Lipid Accumulation or Maturation in Adipocytes.
Jatrorrhizine hydrochloride attenuates hyperlipidemia in a high-fat diet-induced obesity mouse model.
Fatty acid synthase regulates invasion and metastasis of colorectal cancer via Wnt signaling pathway.
miR-22 inhibits tumor growth and metastasis by targeting ATP citrate lyase: evidence in osteosarcoma, prostate cancer, cervical cancer and lung cancer.
Gestational dietary betaine supplementation suppresses hepatic expression of lipogenic genes in neonatal piglets through epigenetic and glucocorticoid receptor-dependent mechanisms.
Acetyl-coenzyme A carboxylase alpha promotion of glucose-mediated fatty acid synthesis enhances survival of hepatocellular carcinoma in mice and patients.
TSH/TSHR Signaling Suppresses Fatty Acid Synthase (FASN) Expression in Adipocytes.
Long noncoding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR-9-mediated RXRA signaling pathway.
Yan Y, Li C, Zhang J, Li R, Yin B, Zhang S, Zhang Y, Zhang X, Han J, Huang J
International journal of biological sciences 2026;22(3):1590-1610
International journal of biological sciences 2026;22(3):1590-1610
Gut-Derived Hippuric Acid Alleviates Hepatic Lipid Metabolism via UGDH/FOXK1/CD36 Axis in Obese Mice.
Chen S, Xue J, Shao Y, Liu H, Zhou F, Gu X, Zhou G, Xu T, Wang D, Tang L
Drug design, development and therapy 2026;20:595588
Drug design, development and therapy 2026;20:595588
Qingyi Decoction Alleviates Alcoholic Pancreatitis by Improving Glycerolipid Homeostasis via the AMPK/SREBP-1c/PPARα Pathway.
Zhang J, Qi Y, Jiang Y, Wei T, Ma S, Fu K, Shen J, Chen C, Li X, Wang G, Leng A, Shang D, Qu J
Journal of inflammation research 2026;19:537259
Journal of inflammation research 2026;19:537259
The D826V point mutation in IREB2 induces lipogenesis in adipose tissues.
Lv Y, Wu C, Xiao J, Yang W, Wang C, Wang J, Huang J, Guo Z, Liao S
Frontiers in cell and developmental biology 2026;14:1724485
Frontiers in cell and developmental biology 2026;14:1724485
Integrating network toxicology and experimental validation to elucidate the molecular mechanism basis of chondrotoxicity of Benzo[a]pyrene in osteoarthritis.
Pan J, Zhang Z, Ma Y, Gao Y, Wang Z, Ma J, Wang X
Ecotoxicology and environmental safety 2026 May;316:120177
Ecotoxicology and environmental safety 2026 May;316:120177
Hepatic IFRD1 suppresses metabolic dysfunction-associated fatty liver disease via GLUD1/α-KG axis.
Geng M, Meng F, Li H, Sun L, Sun X, Ding Y, Shi R, Wang Z, Huang Y, Wang J, Liu Y, Wang J, Little PJ, Xu S, Liu L, Weng J, Luo S
Science bulletin 2026 May 15;71(9):2283-2299
Science bulletin 2026 May 15;71(9):2283-2299
N-acetylglucosamine ameliorates the transition from acute kidney injury to chronic kidney disease by reducing the accumulation of lipid droplets.
Tang Z, Ou Z, Wan H, Tao M, Li X, Huang Y, Tan Q, Peng Q, Dong L, Zhao J
International immunopharmacology 2026 May 15;177:116463
International immunopharmacology 2026 May 15;177:116463
STING-mediated metabolic reprogramming drives lipid peroxidation during Staphylococcus aureus infection.
Yu R, Sun N, Fu S, Fang Y, Feng S, Qiu Y, Wang H, Xu Y, Miao J
International immunopharmacology 2026 May 1;176:116497
International immunopharmacology 2026 May 1;176:116497
Iron overload reprogramming lipid metabolism through the IRP1-SCAP axis in fibroblast-like synoviocytes aggravates bone destruction in rheumatoid arthritis.
Liu Y, Fang L, Wang M, Zhong S, Xiong Y, Hou Y, Ren J, Li Y, Zhu W, Meng X, Lu C, Pan Y
Experimental & molecular medicine 2026 May 1;
Experimental & molecular medicine 2026 May 1;
Nobiletin and polydatin synergistically alleviate triple-negative breast cancer liver metastasis via suppressing ECM1a-mediated fatty acid biosynthesis.
Wang J, Liu WW, Huang QL, Ning HJ, Wang JY, Han XH
Acta pharmacologica Sinica 2026 Mar;47(3):735-749
Acta pharmacologica Sinica 2026 Mar;47(3):735-749
NPM3 functions as a lactyltransferase to promote necroptosis in male diabetic cardiomyopathy mice models via FASN transcription modulation.
Xu H, Jiang X, Wang F, Meng F, Liu Y, Huang J, Li J, Zhu M
Nature communications 2026 Mar 9;17(1)
Nature communications 2026 Mar 9;17(1)
Integrated Multiomic Analysis Provides New Insights into the Adipogenic Differentiation of Porcine Adipocytes and Reveals the Regulatory Role of ACACA in Adipogenesis.
Shen J, Li S, Fu K, Zhang W, Zhu C, Wang R, Sun H, Wen B, Li M, Zhang L, Liu X, Wen Y, Liao C, Qin B, Du H, Bai Y, Hu J, Ding K, Wang L
Journal of agricultural and food chemistry 2026 Mar 4;74(8):7262-7281
Journal of agricultural and food chemistry 2026 Mar 4;74(8):7262-7281
Fermented Black Soybean and Dehulled Adlay Improve Metabolic Syndrome via AMPK-SIRT1 Activation and Gut Microbiota Modulation.
Kuo YR, Zheng YW, Ho PY, Lo YC, Tsai PJ, Pan MH
Journal of agricultural and food chemistry 2026 Mar 4;74(8):6864-6877
Journal of agricultural and food chemistry 2026 Mar 4;74(8):6864-6877
Ski2-like helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responses.
Cui S, Batenburg NL, Coulombe Y, Arumugam A, Walker JR, Sheida SV, Bielinsky AK, Wahl MC, Masson JY, Zhu XD
Cell reports 2026 Mar 24;45(3):117051
Cell reports 2026 Mar 24;45(3):117051
FASN inactivation-induced progranulin (GRN) expression promotes lysosome-dependent cell death to suppress leukemogenesis.
Su M, Li Q, Lv Z, Xie X, Lu Y, He Y, Liu H, Cao H, Ouyang J, Zhang Q, Ma X, Yang Y, Zou A, Liu K, Xu S, Li J, Chen L, Lu X, Yang J, Wu C, Liu L, Zhang L, Sheng Y, Huang Y, Mei Y
Cell reports 2026 Mar 24;45(3):117042
Cell reports 2026 Mar 24;45(3):117042
METTL3 stabilizes FASN mRNA by mediating m(6)A modification to promote malignant progression of diffuse large B-cell lymphoma.
Song X, Zhong Y, Yu N, Zou W, Li W, Lv Q, Luo Q, Zhong X
Cell & bioscience 2026 Mar 18;16(1)
Cell & bioscience 2026 Mar 18;16(1)
The Porcine Colitis Model Recapitulates the Visceral Adipose Metabolic Reprogramming of Human Ulcerative Colitis.
Peng Y, Lv Q, Han X, Zhao C, Luo H, Tang J, Jiang Y, Wu T, Yang S, Wang Y, Tao C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Mar 15;40(5):e71612
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Mar 15;40(5):e71612
cGAS-STING signaling pathway promotes ischemic kidney injury by regulating HK3-mediated lipid accumulation.
Wang D, Zhou Z, Zhao Z, Liu M, Li Y, Mu L, Zhou H, Li X, Zhang F, Tian S, Zhou X, Shi Y
Free radical biology & medicine 2026 Jun;249:246-259
Free radical biology & medicine 2026 Jun;249:246-259
Caveolin-1 deficiency exacerbates liver fibrosis by driving lipid metabolic reprogramming in hepatic stellate cells via DRP1-mediated mitochondrial fission.
Wang Y, Wang X, Lin J, Zhang W, Sun Y, Geng Q, Chen S, Zhang C, Jin L, Hu C
Free radical biology & medicine 2026 Jul;250:203-215
Free radical biology & medicine 2026 Jul;250:203-215
Monascus pilosus SWM-008-Fermented Red Mold Rice and Its Monascinol Ameliorate Non-Alcoholic Fatty Liver Disease via Activation of the AMPK-ATGL Pathway and Enrichment of Butyrate-Producing Bacteria.
Hsieh CP, Hsu YW, Pan TM, Lee CL
Molecular nutrition & food research 2026 Jan;70(1):e70342
Molecular nutrition & food research 2026 Jan;70(1):e70342
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy.
Zhang Y, Shen X, Shen Y, Wang C, Yu C, Han J, Cao S, Qian L, Ma M, Huang S, Wen W, Yin M, Lei QY
Nature 2026 Jan;649(8098):1022-1031
Nature 2026 Jan;649(8098):1022-1031
Gastric bypass surgery improves lipid metabolism and mitochondrial function through the glutamate receptor Grin3a-mediated CaMKKβ/AMPK pathway in a rat model of type 2 diabetes.
Zhang L, Wang J, Tan B, Wang X, Luan Z
Diabetic medicine : a journal of the British Diabetic Association 2026 Jan;43(1):e70170
Diabetic medicine : a journal of the British Diabetic Association 2026 Jan;43(1):e70170
The role of FOXO1/PPARγ in atrazine-induced hepatic lipid metabolism disorders.
Yingchao H, Haoyan M, Zengchen W, Haotang Z, Tong L, Ying Q, Xiaotong W, Yuezhu Z
Toxicology letters 2026 Jan;415:111797
Toxicology letters 2026 Jan;415:111797
Narirutin Reprograms Fatty Acid Metabolism and Inhibits Tumorigenesis via Downregulating ADORA3 Expression in Colorectal Cancer.
Wang H, Jiang R, Liu C, Chen F
Journal of gastroenterology and hepatology 2026 Jan;41(1):202-214
Journal of gastroenterology and hepatology 2026 Jan;41(1):202-214
Targeting aldose reductase in pulmonary fibrosis: Blocking de novo fatty acid synthesis halts pro-fibrotic M2 polarization.
Li J, Zhang Q, Zhao P, Mei X, Shi Y, Shao W, Yu X
International journal of biological macromolecules 2026 Jan;337(Pt 2):149590
International journal of biological macromolecules 2026 Jan;337(Pt 2):149590
Brusatol ameliorates psoriatic dyslipidemia by targeting IL-1β to restore AMPK-mediated lipid homeostasis.
Jiang Y, Zhang S, Guan H, Lv K, Yu J, Li S, Jia R, Zhang X, Ma S, Qu J, Lin J
Chinese medicine 2026 Jan 8;21(1):18
Chinese medicine 2026 Jan 8;21(1):18
From rosemary and coffee to bioactive nanovesicles: exploring new frontiers in food functional ingredients.
d'Adduzio L, Aiello G, Musazzi U, Bollati C, Frigerio G, Fanzaga M, Musco MS, Lammi C
NPJ science of food 2026 Jan 28;10(1)
NPJ science of food 2026 Jan 28;10(1)
The UFL1-AKT positive feedback loop promotes breast cancer progression by enhancing lipid synthesis.
Meng F, Du Y, Liang J, Li H, Wang J, Tang K, Kong R, Sun H, Yin T, Qin J, Yang X, Shan C, Liu M, Yang G, Zhang J, Wang Y, Zhou J, Chen Y
Nature communications 2026 Jan 20;17(1):614
Nature communications 2026 Jan 20;17(1):614
Combination of GLP-1 receptor agonist and Akkermansia muciniphila Akk11 reduces adiposity and ameliorates MASLD in T2D mice.
Gao K, Yin Z, Zhang C, Dong Z, Wang R, Chen Q, Liu X, Jiang C, Wang Y, Guo B, Zhou Z, Jia Z, Sun H, Feng Y
Cell & bioscience 2026 Jan 12;16(1):18
Cell & bioscience 2026 Jan 12;16(1):18
KCNK3 coordinates adipocyte lipid storage and thermogenic shifts via AMPK, modulating a ferroptosis-permissive state.
Zhang L, Hou N, Wang X, Quan L, Yu Z, Du X, Wu S
Cellular signalling 2026 Feb;138:112214
Cellular signalling 2026 Feb;138:112214
Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development.
Tong J, Wang D, Song H, Sun T, Zhao Y, Gu W, Lin L, Zhao Y, Liang Y, Jin X, Fu R, Ju M, Gao J, Ma J, Gao C, Zhang A, Xiao Z, Jiang E, Yang R, Ma S, Zhang L, Shi L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(7):e05249
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(7):e05249
Lysine malonylation regulates human sperm motility.
Cheng Y, Tian Y, Chen H, Peng S, Chen Y, Peng Z, Luo T
Communications biology 2026 Feb 9;9(1):178
Communications biology 2026 Feb 9;9(1):178
Characterization of gRNA-dependent and gRNA-independent off-target binding sites of PspCas13b and RfxCas13d in mammalian cells.
Feng H, Li Z, Zhang H, Zheng Y, Xu B, Zhang Y, Zou L, Wu L
Nucleic acids research 2026 Feb 5;54(4)
Nucleic acids research 2026 Feb 5;54(4)
c-Myc/GRPEL1 maintains fatty acid synthesis via FASN to support PDAC cell proliferation.
Wang J, Zhang L, Chen K, Wei F, Li W, Cui C, Chen F, Wei B, Huang T, Fang H, Cui W
Cell death & disease 2026 Feb 5;17(1):205
Cell death & disease 2026 Feb 5;17(1):205
Combinatorial treatment with donafenib and quercetin suppresses lipid metabolism in HepG2 cells by targeting the CREB1/DRP1/SREBP1 axis.
Xiang L, Shi J, Huang X, Zhou S
Translational cancer research 2026 Feb 28;15(2):97
Translational cancer research 2026 Feb 28;15(2):97
Paeoniflorin Alleviates Metabolic Dysfunction-Associated Steatotic Liver Disease by Inhibiting Hepatic Lipogenesis and Inflammation.
Wei SZ, Dong Y, Zhou HY, Yang J, Lu JF, Zhao YL, Zhao Y, Lu JF
Inflammation 2026 Feb 26;49(1)
Inflammation 2026 Feb 26;49(1)
Macrophage-derived IL-6 reprograms lipid metabolism to promote colorectal cancer development through USP14-mediated FASN deubiquitination.
Yunxin L, Xirui X, Xinyi Z, Chenjing W, Ting Z, Kanghui F, Haixia Y, Zude C, Wan H, Yubing Z, Xianjun F
Journal of translational medicine 2026 Feb 26;24(1)
Journal of translational medicine 2026 Feb 26;24(1)
FOXN3 integrates the KU70/KU80/SREBP-1 complex to regulate lipid metabolism in non-alcoholic fatty liver disease.
Du J, Jin L, Wang S, Hu X, Yu J, Yu J, Huo Q, Wu N, Liu X, Yang Y, Zhang Y, Huang S, Zhou J, Zheng SG, Zheng C, Zhu X
Nucleic acids research 2026 Feb 24;54(5)
Nucleic acids research 2026 Feb 24;54(5)
Erianin inhibits 3T3-L1 adipocyte differentiation through downregulation of CCAAT-enhancer binding protein-α and peroxisome proliferator-activated receptor-γ, lipogenic genes and impairment of mitochondrial respiration.
Yimpreeda H, Laowittawat C, Siritutsoontorn S, Rojvirat P, Kumphune S, Jitrapakdee S
Adipocyte 2026 Dec;15(1):2601405
Adipocyte 2026 Dec;15(1):2601405
Diosgenin alleviates hepatic fibrosis via PI3K/Akt/mTOR mediated fatty acid metabolic reprogramming and NF-κB activation.
Shi Y, Zhang Y, Liu D, Xiang S, Liang S, Lin W, Li S, Zhai X, Cheng B
Journal of ethnopharmacology 2026 Aug 10;367:121747
Journal of ethnopharmacology 2026 Aug 10;367:121747
SREBP1-activated lipid metabolism drives ferroptosis and progression of clear cell renal cell carcinoma.
Wang B, Fu J, Qian J, Wei Y, Bao M, Miao H, Zhao X, Shao K, Song Y, Tan R, Li J, Shao P
Science China. Life sciences 2026 Apr;69(4):1220-1237
Science China. Life sciences 2026 Apr;69(4):1220-1237
CLCC1 governs ER bilayer equilibration to maintain lipid homeostasis.
Wu L, Wang J, Wang Y, Yang J, Yao Y, Wang Y, Huang D, Hu Y, Xu X, Wang R, Du W, Shi Y, Li Q, Liu L, Zhu Y, Li S, Chen FJ, Zhang X, Wang X, Guo Q, Xu L, Li P, Chen XW
Nature 2026 Apr;652(8109):471-480
Nature 2026 Apr;652(8109):471-480
Small extracellular vesicles derived from lipotoxic hepatocytes transport FASN to promote hepatic stellate cell activation.
Shi Y, Yi L, Chen Y, Yang F, Qian H, Abouelnazar FA, Yan Y, Wang Y
Hepatology international 2026 Apr;20(2):451-463
Hepatology international 2026 Apr;20(2):451-463
Dapagliflozin induces renal lipidomic remodeling and systemic metabolic improvement.
Li A, Ye Y, Tang J, Hu J, Shi M, Wu Y, Ji C, Zhang H
Biology direct 2026 Apr 17;21(1)
Biology direct 2026 Apr 17;21(1)
Network toxicology and machine learning revealed the association between non-alcoholic fatty liver disease induced by polystyrene nanoplastics.
Zhang Y, Shi Y, Yang H, Li H, Li C, Liu M, Zhong Y, Huang C, Zhu L, Xu Y, Pan W
Ecotoxicology and environmental safety 2026 Apr 1;314:120058
Ecotoxicology and environmental safety 2026 Apr 1;314:120058
PPARG Activation of Fatty Acid Metabolism Drives Resistance to Anti-HER2 Therapies in HER2-Positive Breast Cancer.
Xiong M, Liu D, Wang X, Ren H, Chi W, Xiu B, Zhang Q, Zhang J, Zhang L, Wang Z, Chen M, Xue J, Chi Y, Wu J
International journal of biological sciences 2025;21(6):2396-2414
International journal of biological sciences 2025;21(6):2396-2414
Rabdosia rubescens Inhibits CYP7A1 Expression and Induces Autophagy to Reduce Alcohol-Induced Liver Damage in Mice.
Zou X, Chen W, Shao Y, Shi T, Ke Y
Canadian journal of gastroenterology & hepatology 2025;2025:9507266
Canadian journal of gastroenterology & hepatology 2025;2025:9507266
METTL3/miR-192-5p/SCD1 Axis Regulates Lipid Metabolism to Affect T Cell Differentiation in Asthma.
Chen Z, Yan D, Guo S, Song Y, Zhang X, Gu W, Dong H, Huang L
Mediators of inflammation 2025;2025:4955849
Mediators of inflammation 2025;2025:4955849
Rapamycin and Chloroquine Modulate Insulin Resistance and Hepatic Steatosis in a High-Fat/High-Cholesterol Diet-Induced Metabolic Dysfunction-Associated Steatotic Liver Disease Mouse Model.
Liu Q, Du Q, Yuan X, Zhang T, Li J, Xu J, Xie R
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:4059-4072
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:4059-4072
Integrated Single-Cell and Transcriptome Analysis with Experimental Validation Reveals PANoptosis-Related Gene Signatures in the Immune Microenvironment of Autoimmune Thyroiditis.
Zhao Z, Liu Z, Wang Q, Gao H, Song N, Yang X
Journal of inflammation research 2025;18:12123-12143
Journal of inflammation research 2025;18:12123-12143
Xingxiao Pill Suppressed the Progression of Non-Small Cell Lung Cancer by Targeting SREBP1/FASN-Induced Fatty Acid Biosynthesis via PI3K/AKT/mTOR Signaling Pathway.
Zhou X, Hu X, Zhang Z, Lin S, Lin X, Zhou T, Bai Y, Hu K
Cancer management and research 2025;17:1487-1501
Cancer management and research 2025;17:1487-1501
FASN promotes the stemness of cancer stem cells and protects colorectal cancer cells from ferroptosis by inhibiting the activation of SREBP2.
Wang M, Ge F, Wu C, Su B, Dong X, Xu S, Shi H
Frontiers in immunology 2025;16:1611375
Frontiers in immunology 2025;16:1611375
Gallic acid mitigates high-fat and high-carbohydrate diet-induced steatohepatitis by modulating the IRF6/PPARγ signaling pathway.
Qiu J, Fu L, Xue Y, Yang Y, Qiao F, Zhu W, Gao Y, Fang M, Liu Y, Gao Z, Guan Y, Gao Y, Zhang X, Shang Z
Frontiers in pharmacology 2025;16:1563561
Frontiers in pharmacology 2025;16:1563561
Reversed role of CD36 deficiency in high-fat diet or methionine/choline-deficient diet-induced hepatic steatosis and steatohepatitis.
Zhu W, Ma J, Zhang T, Zhu M, Duan Y, Yang X, Chen Y
Frontiers in pharmacology 2025;16:1522177
Frontiers in pharmacology 2025;16:1522177
FOXK2 regulates fatty acid metabolism and promotes cervical cancer progression by activating the mTOR/DRP1 signaling axis.
Liao D, Zeng S, Li C, Yao Y, Guo M, Cui Y, Huang H
Frontiers in cell and developmental biology 2025;13:1615454
Frontiers in cell and developmental biology 2025;13:1615454
Matrix stiffness boosts PDAC chemoresistance via SCD1-dependent lipid metabolic reprogramming.
Zhang X, Zhu B, Yan J, Chen X, Wu D, Wang Z, Guan X, Huang Y, Zhao Y, Yang Y, Guo Y
Regenerative biomaterials 2025;12:rbaf056
Regenerative biomaterials 2025;12:rbaf056
Jianpi Yangzheng Xiaozheng granule induced ferroptosis to suppress gastric cancer progression through reprogramming lipid metabolism via SCD1/Wnt/β-catenin axis.
Wang X, Li J, Qin R, Yin Y, Li J, Lin S, Zou X
Frontiers in molecular biosciences 2025;12:1523494
Frontiers in molecular biosciences 2025;12:1523494
Knockdown of ACC1 promotes migration and invasion of U251 glioma cells by epigenetically suppressing SDH.
Wei X, Wang Y, Zhao W, Yang W, Tang J, Zhao B, Liu Y
International journal of oncology 2025 Sep;67(3)
International journal of oncology 2025 Sep;67(3)
Lipin1-dependent transcriptional inactivation of SREBPs contributes to selinexor sensitivity in multiple myeloma.
Wang JY, Chen MP, Jiang JX, Wan YK, Li X, Zhang YW, Fang Y, Huang HH, Qin ZY, Hou J
Acta pharmacologica Sinica 2025 Sep;46(9):2496-2508
Acta pharmacologica Sinica 2025 Sep;46(9):2496-2508
CHAF1A Promotes Preadipocyte Differentiation and Contributes to Macrosomia in Gestational Diabetes Mellitus.
Xia D, Xu X, Zhang Y, Zhang C, Wang H
Reproductive sciences (Thousand Oaks, Calif.) 2025 Sep;32(9):3086-3102
Reproductive sciences (Thousand Oaks, Calif.) 2025 Sep;32(9):3086-3102
Mechanisms of metabolic-associated fatty liver disease induced by 48-week PCB138 exposure and theabrownin intervention.
Han J, Liu C, Chen Z, Ruan F, Xue F, Ye L, Yu Y, Zuo Z, He C
Environment international 2025 Sep;203:109780
Environment international 2025 Sep;203:109780
Proinflammatory polarization of adipose tissue macrophages in cows with subclinical ketosis constitutes a critical driver of adipose tissue remodeling and inflammation.
Zhao B, Li M, Zhang H, Chang R, Wang J, Zhao W, Yang Y, Usman M, Loor JJ, Xu C
Journal of animal science and biotechnology 2025 Sep 29;16(1):130
Journal of animal science and biotechnology 2025 Sep 29;16(1):130
Klebsiella pneumoniae Induces Ferroptosis and Lactation Dysfunction in Bovine Mastitis via NCOA4-Mediated Ferritinophagy.
Mao P, Wang Z, Duan J, Dong P, Yuan C, Liu K, Guo L, Cui L, Dong J, Meng X, Zhu G, Li J, Wang H
Journal of agricultural and food chemistry 2025 Sep 24;73(38):24326-24342
Journal of agricultural and food chemistry 2025 Sep 24;73(38):24326-24342
Breviscapine regulates lipid metabolism of microglia via the ADORA1/PPARα/ACOX1 pathway to promote spinal cord injury recovery.
Shi F, Wang S, Wu C, Wen H, Zhou W
International immunopharmacology 2025 Sep 23;162:115145
International immunopharmacology 2025 Sep 23;162:115145
Chronic Waterborne Exposure to Polystyrene Microplastics Induces Kupffer Cell Polarization Imbalance and Hepatic Lipid Accumulation.
Li T, Yao Z, Huang Y, Li R, Zhang L, Chen R, Gu W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Sep 15;39(17):e70980
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Sep 15;39(17):e70980
Triclocarban Disrupts Hepatic Lipid Homeostasis and Promotes Endoplasmic Reticulum Stress in Mice: A Multiomics Investigation.
Song Q, Zhang R, Liu X, Ji X, Han A, He F, Ding R, Zhang H
Chemical research in toxicology 2025 Sep 15;38(9):1564-1575
Chemical research in toxicology 2025 Sep 15;38(9):1564-1575
Peroxisomal metabolism of branched fatty acids regulates energy homeostasis.
Liu X, He A, Lu D, Hu D, Tan M, Abere A, Goodarzi P, Ahmad B, Kleiboeker B, Finck BN, Zayed M, Funai K, Brestoff JR, Javaheri A, Weisensee P, Mittendorfer B, Hsu FF, Van Veldhoven PP, Razani B, Semenkovich CF, Lodhi IJ
Nature 2025 Oct;646(8087):1223-1231
Nature 2025 Oct;646(8087):1223-1231
TRIM34 inhibits triple-negative breast cancer progression by attenuating fatty acid synthesis via facilitating FASN ubiquitination.
Li Y, Shan J, Liu S, Shen Y, Niu L, Mao Q, Chen X
Biochimica et biophysica acta. Molecular basis of disease 2025 Oct;1871(7):167958
Biochimica et biophysica acta. Molecular basis of disease 2025 Oct;1871(7):167958
Androgen regulates seasonal changes in triglyceride synthesis through the AR-SREBP1-FASN axis in the scented glands of muskrats (Ondatra zibethicus).
Shi X, Gao Q, Lu W, Xie Y, Zhang H, Zhang D, Liu Y, Weng Q
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Oct;1870(7):159675
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Oct;1870(7):159675
High-Calorie Diet During Pregnancy Leads to Muscular Fibrosis and Neuromuscular Damage in Offspring Mice.
Son JS, Chae SA, Chun YH, Wang H, Jiang Z, Du M
Journal of cachexia, sarcopenia and muscle 2025 Oct;16(5):e70027
Journal of cachexia, sarcopenia and muscle 2025 Oct;16(5):e70027
Mechanism by which CAP regulates the "cold-heat" balance in osteosarcoma model mice: an integrative study of metabolomics, transcriptomics, and network pharmacology.
Wang Z, Zhang S, Li S, Zhao G, Zhang Y, Zhang X, Sun M, Lu Y, Song E, Quan C, Lv C, Wang Y
Journal of translational medicine 2025 Oct 27;23(1):1177
Journal of translational medicine 2025 Oct 27;23(1):1177
FASN inhibits ferroptosis in breast cancer via USP5 palmitoylation-dependent regulation of GPX4 deubiquitination.
Qian Z, Jiang Y, Cai Y, Gao E, Wang C, Dong J, Wang F, Liu L, Wu D, Zhang F, Wang Y, Ning X, Li Q, You Y, Gu Y, Mei J, Zhao X, Zhang Y
Journal of experimental & clinical cancer research : CR 2025 Oct 14;44(1):289
Journal of experimental & clinical cancer research : CR 2025 Oct 14;44(1):289
Maternal exposure to high level of ursodeoxycholic acid during pregnancy promotes hepatic lipid deposition in the offspring by reducing the methylation level of Fasn gene.
Hu D, Wu X, Hou M, Song P, Chen Q, Ni Y
Biochemical pharmacology 2025 Nov;241:117156
Biochemical pharmacology 2025 Nov;241:117156
Fatty acid metabolism-related signature suggests an oncogenic role of FASN in cervical cancer.
Yang Q, Zhang J, Shang X, Sun B, Wang T, Wu Y, Zhu C, Xiang W, Wang H
Translational cancer research 2025 Nov 30;14(11):8032-8054
Translational cancer research 2025 Nov 30;14(11):8032-8054
Stabilization of FASN by USP5-mediated deubiquitination promotes hepatocellular carcinoma progression.
Fang Q, Luo C, Lu Y, Chen X, Zhan P, Yao Q, Wu H, Wang F, Yin Z, Xie C
Oncogenesis 2025 Nov 28;14(1):46
Oncogenesis 2025 Nov 28;14(1):46
Divergent Regulation of Mammary Lipogenesis by trans-10, cis-12 and cis-9, trans-11 CLA Isomers Is Determined by Receptor-Specific Signaling.
Cheng S, Zhao A, Lin X, Wang Z
Animals : an open access journal from MDPI 2025 Nov 26;15(23)
Animals : an open access journal from MDPI 2025 Nov 26;15(23)
Unveiling plumbagin as a novel metabolic modulator to suppress ACC1-mediated de novo lipogenesis in non-small cell lung cancer.
Deng ZH, He LJ, Wei S, Li CS, Chen Y, Ai XY, Chaotham C, Jiranusornkul S, Zhang PC, Luo Z, Xing SP, Yang J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157438
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157438
The cyclic peptide mallotumide A inhibits colon and breast cancer cell growth and motility by targeting cellular respiration and lipogenesis.
Laowittawat C, Sawektreeratana N, Katewongsa K, Payomhom P, Hongthong S, Reutrakul V, Kuhakarn C, Jitrapakdee S
Scientific reports 2025 Nov 19;15(1):40774
Scientific reports 2025 Nov 19;15(1):40774
ARMC10 Drives Glioblastoma Progression Through Activating Notch Pathway.
Feng B, Gao T, Chen L, Xing Y
Molecular carcinogenesis 2025 May;64(5):883-896
Molecular carcinogenesis 2025 May;64(5):883-896
FTO aggravates podocyte injury and diabetic nephropathy progression via m6A-dependent stabilization of ACC1 mRNA and promoting fatty acid metabolism.
Chang K, Hong F, Liu H, Fang Y, Wang H, Song N, Ning Y, Lu Z, Jin S, Dai Y, Ding X
Biochemical pharmacology 2025 May;235:116819
Biochemical pharmacology 2025 May;235:116819
Steam explosion modified pea peptides alleviates hepatosteatosis by regulating lipid metabolism pathways and promoting autophagy.
Zhang J, Song L, Li T, Zhu L, Wang T, Zhao P, Ma Y, Zhao J, Huang X
Food research international (Ottawa, Ont.) 2025 May;208:116182
Food research international (Ottawa, Ont.) 2025 May;208:116182
Insight into perfluorooctanoic acid-induced impairment of mouse embryo implantation via single-cell RNA-seq.
Sheng X, Yang Y, Tian J, Zhang Z, Ding L, Zhao J
Journal of hazardous materials 2025 May 5;488:137375
Journal of hazardous materials 2025 May 5;488:137375
Baicalin mitigates alcoholic-associated liver disease via SOCS1-driven reprogramming of macrophages.
Huang S, Wang Y, Wen J, Ji W, Zeng Q, Deng K, Li M, Kuang S, Zhang W, Chan M, Zhou C, Lv Z, Huang S
Chinese medicine 2025 May 13;20(1):63
Chinese medicine 2025 May 13;20(1):63
Integrated prognostic assessment of apoptosis and chemotherapy related gene in bladder cancer: a prognostic signature.
Zhao K, Xu G, Jin J, Peng C, Chen J, Li Y, Wang W, Pan S
Discover oncology 2025 May 10;16(1):718
Discover oncology 2025 May 10;16(1):718
Dietary coconut oil lowered circulating fetuin-A levels and hepatic expression of fetuin-A in KK/TaJcl mice.
Iizuka Y, Kitagawa C, Tamura T, Ueshiba H, Hirako S, Osaka T, Kim H, Yanagisawa N
Journal of clinical biochemistry and nutrition 2025 Mar;76(2):131-138
Journal of clinical biochemistry and nutrition 2025 Mar;76(2):131-138
Inhibition of STRA6 suppresses NSCLC growth via blocking STAT3/SREBP-1c axis-mediated lipogenesis.
Zhou Y, Zhou R, Wang N, Zhao T, Qiu P, Gao C, Chang M, Lin N, Zhang X, Li JZ, Wang Q
Molecular and cellular biochemistry 2025 Mar;480(3):1715-1730
Molecular and cellular biochemistry 2025 Mar;480(3):1715-1730
The effects of citalopram and sertraline on adipogenesis and lipogenesis in 3T3-L1 cells.
Bozdag D, Entezari B, Gurer-Orhan H
Toxicology letters 2025 Mar;405:67-75
Toxicology letters 2025 Mar;405:67-75
FASN promotes lipid metabolism and progression in colorectal cancer via the SP1/PLA2G4B axis.
Liu X, Lu J, Ni X, He Y, Wang J, Deng Z, Zhang G, Shi T, Chen W
Cell death discovery 2025 Mar 28;11(1):122
Cell death discovery 2025 Mar 28;11(1):122
TSPAN31 Activates Fatty Acid Metabolism and PI3K/AKT Pathway to Promote Tumor Progression in Breast Cancer.
Luo W, Sun Y, Cao L
Molecular carcinogenesis 2025 Jun;64(6):1078-1089
Molecular carcinogenesis 2025 Jun;64(6):1078-1089
Exogenous hydrogen sulfide improves non-alcoholic fatty liver disease by inhibiting endoplasmic reticulum stress/NLRP3 inflammasome pathway.
Fu X, Zhang Q, Chen Y, Li Y, Wang H
Molecular and cellular biochemistry 2025 Jun;480(6):3813-3839
Molecular and cellular biochemistry 2025 Jun;480(6):3813-3839
CD36 molecule and AMP-activated protein kinase signaling drive docosahexaenoic acid-induced lipid remodeling in goat mammary epithelial cells.
Wu J, Luo J, He Q, Zhang F, Shi C, Zhao J, Li C, Deng W
International journal of biological macromolecules 2025 Jun;311(Pt 4):144076
International journal of biological macromolecules 2025 Jun;311(Pt 4):144076
Rotenone adaptation promotes migration and invasion of p53-wild-type colon cancer through lipid metabolism.
Shi Y, Cao Z, Ge L, Lei L, Tao D, Zhong J, Xu D, Geng T, Li X, Li Z, Xing S, Wu X, Wang Z, Li L
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2025 Jun;27(6):2557-2567
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2025 Jun;27(6):2557-2567
Ginsenoside Rk1 Ameliorates Non-Alcoholic Fatty Liver Disease by Targeting CD36 to Modulate the AMPK Signaling Pathway.
Wu Y, Duan Z, Qu L, Liu Y, Ma X, Fan D
Food research international (Ottawa, Ont.) 2025 Jun;211:116426
Food research international (Ottawa, Ont.) 2025 Jun;211:116426
Hawthorn total flavonoids ameliorate hyperlipidemia through AMPK/SREBP1-c and PPARα/PGC-1α/CPT-1A pathway activation and gut microbiota modulation.
Zheng L, Lu Z, Ma Y, Cui P, Zhang X, Gan J, Li G
Journal of the science of food and agriculture 2025 Jun;105(8):4326-4337
Journal of the science of food and agriculture 2025 Jun;105(8):4326-4337
Dual-omics analysis of transcriptome and translatome unveils lycopene-induced triglyceride accumulation mechanisms in muscle cells.
Liu S, Luo Z, Huang T, Liu S, Li Y, Zhou L
Biochemical and biophysical research communications 2025 Jun 8;765:151878
Biochemical and biophysical research communications 2025 Jun 8;765:151878
Antrodia cinnamomea Extract Attenuates Obesity by Targeting Adipogenic Pathways and Gut Dysbiosis in High-Fat Diet-Fed Mice.
Lin KT, Lee SY, Ya-Jy L, Wu PJ, Chang TC, Chang WL, Yen IC
International journal of molecular sciences 2025 Jun 18;26(12)
International journal of molecular sciences 2025 Jun 18;26(12)
Metal-organic framework nanomaterials alter cellular metabolism in bladder cancer.
Wang N, Song W, Ji J, Guo W, Du Q
Ecotoxicology and environmental safety 2025 Jun 15;298:118292
Ecotoxicology and environmental safety 2025 Jun 15;298:118292
Senkyunolide I suppresses hepatic stellate cell activation and liver fibrosis by reprogramming VDR-dependent fatty acid metabolism.
Zhu M, Ren L, Xiao W, Wang L, Hu Z, Wang N
Chinese medicine 2025 Jun 13;20(1):85
Chinese medicine 2025 Jun 13;20(1):85
Thermo-responsive nano-hydrogel-based delivery of Saikosaponin a to enhance anti-PD-1 therapy in osteosarcoma.
Chen YQ, Yang D, Li K, Liu JS, Feng HJ, Zhou JW
Nanomedicine (London, England) 2025 Jul;20(14):1677-1691
Nanomedicine (London, England) 2025 Jul;20(14):1677-1691
Integratomic investigation to assess the liver lipidomic and antiinflammatory activity of lupin protein hydrolysate.
Casati S, Dei Cas M, d'Adduzio L, Cruz-Chamorro I, Santos-Sánchez G, Bollati C, Fanzaga M, Pedroche J, Millán-Linares MDC, Roda G, Carrillo-Vico A, Lammi C
NPJ science of food 2025 Jul 28;9(1):154
NPJ science of food 2025 Jul 28;9(1):154
The Ski2 helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responses.
Cui S, Batenburg NL, Coulombe Y, Arumugam A, Walker JR, Sheida SV, Bielinsky AK, Wahl MC, Masson JY, Zhu XD
bioRxiv : the preprint server for biology 2025 Jul 26;
bioRxiv : the preprint server for biology 2025 Jul 26;
The N-terminal domain of gasdermin D induces liver fibrosis by reprogrammed lipid metabolism.
Wang X, Ning C, Cheng X, Wu Z, Wu D, Ding X, Ju C, Zhou Z, Wan L, Zhao W, Shi P
Animal models and experimental medicine 2025 Jan;8(1):114-125
Animal models and experimental medicine 2025 Jan;8(1):114-125
Hsp90α promotes lipogenesis by stabilizing FASN and promoting FASN transcription via LXRα in hepatocellular carcinoma.
Deng Z, Liu L, Xie G, Zheng Z, Li J, Tan W, Deng Y, Zhang J, Liang M, Wu Y, Zhou Z, Li Y, Chen Y, Huang Y, Su H, Wu G, Shi X, Cen S, Liao Y, Liu Y, Zou F, Chen X
Journal of lipid research 2025 Jan;66(1):100721
Journal of lipid research 2025 Jan;66(1):100721
Foxk2 Enhances Adipogenic Differentiation by Relying on the Transcriptional Activation of Peroxisome Proliferator-Activated Receptor Gamma.
Zhang S, You Y, Li R, Li M, Li Y, Yuan H, Zhou J, Zhen R, Liu Y, Wang B, Zhu E
Journal of cellular and molecular medicine 2025 Jan;29(1):e70332
Journal of cellular and molecular medicine 2025 Jan;29(1):e70332
Abnormal ac4C modification in metabolic dysfunction associated steatotic liver cells.
Zhang X, Zheng Y, Yang J, Yang Y, He Q, Xu M, Long F, Yang Y
Scientific reports 2025 Jan 6;15(1):1013
Scientific reports 2025 Jan 6;15(1):1013
Diosgenin attenuates nonalcoholic fatty liver disease through mTOR-mediated inhibition of lipid accumulation and inflammation.
Yin G, Liang H, Cheng Y, Chen S, Zhang X, Meng D, Yu W, Liu H, Song C, Zhang F
Chemico-biological interactions 2025 Jan 5;405:111306
Chemico-biological interactions 2025 Jan 5;405:111306
Fatty Acid Esterification of Octacosanol Attenuates Triglyceride and Cholesterol Synthesis in Mice.
Kamchonemenukool S, Koh YC, Ho PY, Pan MH, Weerawatanakorn M
Journal of agricultural and food chemistry 2025 Jan 29;73(4):2430-2442
Journal of agricultural and food chemistry 2025 Jan 29;73(4):2430-2442
Integrated network pharmacology, metabolomics and molecular docking analysis to reveal the mechanisms of quercetin in the treatment of hyperlipidemia.
Chen T, Wang T, Shi Y, Deng J, Yan X, Zhang C, Yin X, Liu W
Journal of pharmaceutical and biomedical analysis 2025 Jan 1;252:116507
Journal of pharmaceutical and biomedical analysis 2025 Jan 1;252:116507
Lactamase β reprograms lipid metabolism to inhibit the progression of endometrial cancer through attenuating MDM2-mediated p53 ubiquitination and degradation.
Zhou T, Li X, Zhao F, Zhou J, Sun B
Archives of biochemistry and biophysics 2025 Feb;764:110287
Archives of biochemistry and biophysics 2025 Feb;764:110287
Small molecule-driven LKB1 deacetylation is responsible for the inhibition of hepatic lipid response in NAFLD.
Qin W, Ding Y, Zhang W, Sun L, Weng J, Zheng X, Luo S
Journal of lipid research 2025 Feb;66(2):100740
Journal of lipid research 2025 Feb;66(2):100740
Melittin suppresses ovarian cancer growth by regulating SREBP1-mediated lipid metabolism.
Wu R, Li N, Huang W, Yang Y, Zang R, Song H, Shi J, Zhu S, Liu Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Feb;137:156367
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Feb;137:156367
Natural molecule isoliquiritigenin mitigates MASH and liver fibrosis in mice by promoting autophagy through the PI3K/Akt signaling pathway.
Liu R, Zhang Y, Liu M, Shang Z, Song S, Zhang Y, Zhou Y, Tu C
The Journal of nutritional biochemistry 2025 Feb;136:109808
The Journal of nutritional biochemistry 2025 Feb;136:109808
Mechanism of O-GlcNAcylation regulating liver lipid synthesis in mice through FASN.
Li X, Zhang Z, Zhang M, Cao Y, Zhou W, Kou L, Guo W, Zhang B, Li S, Xu B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Feb 28;39(4):e70359
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Feb 28;39(4):e70359
Liver ALKBH5 regulates glucose and lipid homeostasis independently through GCGR and mTORC1 signaling.
Ding K, Zhang Z, Han Z, Shi L, Li X, Liu Y, Li Z, Zhao C, Cui Y, Zhou L, Xu B, Zhou W, Zhao Y, Wang Z, Huang H, Xie L, Chen XW, Chen Z
Science (New York, N.Y.) 2025 Feb 28;387(6737):eadp4120
Science (New York, N.Y.) 2025 Feb 28;387(6737):eadp4120
Lipogenic enzyme FASN promotes mutant p53 accumulation and gain-of-function through palmitoylation.
Liu J, Shen Y, Liu J, Xu D, Chang CY, Wang J, Zhou J, Haffty BG, Zhang L, Bargonetti J, De S, Hu W, Feng Z
Nature communications 2025 Feb 19;16(1):1762
Nature communications 2025 Feb 19;16(1):1762
Isoliquiritigenin Ameliorates High-Fat Diet-Induced Obesity in Mice by Activating Brown Adipose Tissue.
Zhao L, Li M, Zhu Q, Fang X, Yang H, Zhao Y
International journal of molecular sciences 2025 Feb 14;26(4)
International journal of molecular sciences 2025 Feb 14;26(4)
Vitisin A Outperforms Cyanidin-3-O-Glucoside in Triglyceride Reduction by Modulating Hepatic Lipogenesis and Fatty Acid β-Oxidation.
Li Y, Li X, Liu J, Jayavanth P, Bai W, Jiao R
International journal of molecular sciences 2025 Feb 11;26(4)
International journal of molecular sciences 2025 Feb 11;26(4)
Ferulic acid from Angelica sinensis (Oliv.) Diels ameliorates lipid metabolism in alcoholic liver disease via AMPK/ACC and PI3K/AKT pathways.
Lu J, Wang C
Journal of ethnopharmacology 2025 Feb 10;338(Pt 3):119118
Journal of ethnopharmacology 2025 Feb 10;338(Pt 3):119118
miRNA-novel-216 regulated fatty acid composition and progesterone synthesis in goat granulosa cells by targeting the TPD52.
Jia Y, Xu Q, Wang P, Liu Z, Zhang R, Liu K, Ling Y, Liu Y, Chu M
Reproduction (Cambridge, England) 2025 Feb 1;169(2)
Reproduction (Cambridge, England) 2025 Feb 1;169(2)
IMUP promotes fatty acid metabolism and lung cancer progression by regulating TGF-β/SMAD3 signaling pathway.
Wu S, Liu F, Yao X, Lei Y, Wang W
Tissue & cell 2025 Dec;97:103061
Tissue & cell 2025 Dec;97:103061
TsR-0072 inhibits colorectal cancer progression through modulating lipid and vitamin D(3) metabolic reprogramming and inactivating the Wnt/β-catenin signalling pathway.
Qi Q, Chen B, Wu J, Xu J, Bao H, Jin K, Chen L, Zhu G, Wang F
Annals of medicine 2025 Dec;57(1):2531253
Annals of medicine 2025 Dec;57(1):2531253
FASN regulates CSE-induced apoptosis, oxidative stress and mitochondrial damage in type 2 alveolar epithelial cells by regulating NRF2 expression and nuclear translocation.
Yang K, Zhu G, Peng T, Cheng Y, Guo X
Redox report : communications in free radical research 2025 Dec;30(1):2550412
Redox report : communications in free radical research 2025 Dec;30(1):2550412
Tryptophan derivatives as non-invasive diagnostic indicators for obesity-related MASLD in children and adolescents.
Zhan S, Wang X, Wang C, Zhu B, Gao J, Peng Z, Wang R, Yang Y, Zhang L, Wang T, Wu J, Wu W, Huang K, Dong G, Ren Q, Wang S, Wang S, Zhou X, Xu L, Fu J, Guo X
Diabetes, obesity & metabolism 2025 Dec;27(12):7544-7560
Diabetes, obesity & metabolism 2025 Dec;27(12):7544-7560
Gut-liver axis mechanisms of Hippophae rhamnoides L. in non-alcoholic fatty liver disease prevention.
Ma J, Li Y, Yang Y, Zhao L, Jiang Y, Wong TW, Zhang D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Dec;149:157517
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Dec;149:157517
Discovery of highly potent marine-derived compound Penicolinate H reveals SREBP-1 mediated lipogenesis as a druggable vulnerability in gastric cancer.
Chen J, Cui H, Wang X, Zeng Y, Pan D, Chen J, Zhang Z, An Y, Gu Z, Cai G, Wang H, Yu M, Yang B, Zhou S, Tan J, Liu L, Wang J, Li J, Han F
Journal of translational medicine 2025 Dec 9;23(1):1390
Journal of translational medicine 2025 Dec 9;23(1):1390
Fatty acid synthase may facilitate the trafficking of bovine alpha herpesvirus 1 out of the Golgi apparatus, potentially promoting viral infection.
Ma X, Gu W, Li X, Ding X, Zhu L
Microbiology spectrum 2025 Dec 2;13(12):e0138825
Microbiology spectrum 2025 Dec 2;13(12):e0138825
Integrated analysis of lactylation modification and proteomics revealed potential epigenetic regulation in intramuscular fat deposition of Xidu black pigs.
Chen T, Zhou J, Li M, Li Z, Feng Y, Qiao M, Xu Z, Chen D, Sun H, Peng X, Wu J, Mei S
BMC genomics 2025 Dec 18;27(1):86
BMC genomics 2025 Dec 18;27(1):86
Early life exposure to environmental levels of PCB138 induces lipid metabolism disorders through activating aryl hydrocarbon receptor in female mice.
Zhu S, He R, Ruan J, Chen P, Zhang Y, Yang C, Wang W, He C, Zuo Z
Environmental research 2025 Dec 15;287:123038
Environmental research 2025 Dec 15;287:123038
EGCG and Taurine Synergistically Ameliorate Lipid Metabolism Disorder by Modulating Gut Microbiota and PPARα/FAS Signaling Pathway.
Xiao Y, Yang M, Cai M, Zhang H, Hu K, Duan Y
Nutrients 2025 Aug 9;17(16)
Nutrients 2025 Aug 9;17(16)
CircZFR/YTHDF3 axis drives lymph node metastasis in cervical cancer via FASN translation.
Zhou M, Gao Y, Zhang Y, He L, Gao B, Zhang Y, Claret FX, Calin GA, Wang D
Molecular cancer 2025 Aug 21;24(1):218
Molecular cancer 2025 Aug 21;24(1):218
VDR Decrease Enhances the Efficacy of 1,25-Dihydroxyvitamin D3 Inhibiting Gefitinib Resistance by Regulating EGFR/FASN Loop in NSCLC Cells.
Yang J, Fang M, Hou M, Duan Y, Wang J, Hu K, Liu S, Liu X, Peng X, Ding X, Jia Z
Pharmaceuticals (Basel, Switzerland) 2025 Aug 21;18(8)
Pharmaceuticals (Basel, Switzerland) 2025 Aug 21;18(8)
MOSPD1 facilitates fatty acid metabolism and gastric cancer progression by promoting the MAPK pathway.
Wang C, Qiu Y, Zheng X, Chen S, He C
Tissue & cell 2025 Apr;93:102752
Tissue & cell 2025 Apr;93:102752
IRX5 Promoted SREBP1-Mediated de Novo Fatty Acid Synthesis via HMGN4 in Hepatocellular Carcinoma.
Zhu L, Xu Y, Huang C, Li C, Zhang Y, Li X, Pan W, Zeng Z
Journal of cellular and molecular medicine 2025 Apr;29(7):e70441
Journal of cellular and molecular medicine 2025 Apr;29(7):e70441
Accumulation of Damaging Lipids in the Arf1-Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia.
Li X, Jin S, Wang D, Wu Y, Tang X, Liu Y, Yao T, Han S, Sun L, Wang Y, Hou SX
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(16):e2414260
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(16):e2414260
LIMA1 O-GlcNAcylation Promotes Hepatic Lipid Deposition through Inducing β-catenin-Regulated FASn Expression in Metabolic Dysfunction-Associated Steatotic Liver Disease.
Yang F, Chen Y, Zheng G, Gu K, Fan L, Li T, Zhu L, Yan Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2415941
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2415941
High expression of myeloperoxidase may be related to the occurrence of urethral fistula in hypospadias patients after tubularized-incised plate urethroplasty repair.
Wang X, Qu Y, Zhu G, Liu W
Translational pediatrics 2025 Apr 30;14(4):571-581
Translational pediatrics 2025 Apr 30;14(4):571-581
IGF2BP3/ESM1/KLF10/BECN1 positive feedback loop: a novel therapeutic target in ovarian cancer via lipid metabolism reprogramming.
Gao A, Zou J, Zeng T, Qin M, Tang X, Yi T, Song G, Zhong J, Zeng Y, Zhou W, Gao Q, Zhang Q, Zhang J, Li Y
Cell death & disease 2025 Apr 17;16(1):308
Cell death & disease 2025 Apr 17;16(1):308
Darolutamide-mediated phospholipid remodeling induces ferroptosis through the SREBP1-FASN axis in prostate cancer.
Li B, Cheng B, Huang H, Huang S, Yu S, Li Z, Peng S, Du T, Xie R, Huang H
International journal of biological sciences 2024;20(12):4635-4653
International journal of biological sciences 2024;20(12):4635-4653
Protective effects of small RNAs encapsulated in Artemisia Capillaris-derived exosomes against non-alcoholic fatty liver disease.
Xu M, Ma L, Liang H, Tang W, Gu S
Frontiers in pharmacology 2024;15:1476820
Frontiers in pharmacology 2024;15:1476820
Development and validation of a glycolysis-associated gene signature for predicting the prognosis, immune landscape, and drug sensitivity in bladder cancer.
Shen C, Suo Y, Guo J, Su W, Zhang Z, Yang S, Wu Z, Fan Z, Zhou X, Hu H
Frontiers in immunology 2024;15:1430583
Frontiers in immunology 2024;15:1430583
Traditional Chinese Medicine formula Dai-Zong-Fang alleviating hepatic steatosis in db/db mice via gut microbiota modulation.
Zhang LW, Zhu LL, Zhu XY, Fu SQ, Liu XM
Frontiers in pharmacology 2024;15:1337057
Frontiers in pharmacology 2024;15:1337057
Integrative proteogenomic profiling of high-risk prostate cancer samples from Chinese patients indicates metabolic vulnerabilities and diagnostic biomarkers.
Dong B, Xu JY, Huang Y, Guo J, Dong Q, Wang Y, Li N, Liu Q, Zhang M, Pan Q, Wang H, Jiang J, Chen B, Shen D, Ma Y, Zhai L, Zhang J, Li J, Xue W, Tan M, Qin J
Nature cancer 2024 Sep;5(9):1427-1447
Nature cancer 2024 Sep;5(9):1427-1447
The developmental pattern related to fatty acid uptake and oxidation in the yolk sac membrane and jejunum during embryogenesis in Muscovy duck.
Li H, Zhang X, Wang X, Wu Q, Zheng W, Liu C, Wei S, Zuo X, Xiao W, Ye H, Wang W, Yang L, Zhu Y
Poultry science 2024 Sep;103(9):103929
Poultry science 2024 Sep;103(9):103929
Effects of Mao tea from Nankun Mountain on nonalcoholic fatty liver disease in mice.
Zhang W, Feng L, Li P, Wang A, Dai C, Qi Y, Lu J, Xu X
Food & function 2024 Sep 30;15(19):9863-9879
Food & function 2024 Sep 30;15(19):9863-9879
Clinopodium gracile Alleviates Metabolic Dysfunction-Associated Steatotic Liver Disease by Upregulating Peroxisome Proliferator-Activated Receptor α and Inhibiting Mitochondrial Oxidative Damage.
Ren M, Ren J, Zheng J, Sha X, Lin Y, Wu F
Antioxidants (Basel, Switzerland) 2024 Sep 20;13(9)
Antioxidants (Basel, Switzerland) 2024 Sep 20;13(9)
Two novel compounds inhibit Flavivirus infection in vitro and in vivo by targeting lipid metabolism.
Zhou J-f, Zhang M-r, Wang Q, Li M-z, Bai J-s, Dai Q, Zhang Y-h, Yan M-x, Li X-h, Chen J, Liu Y-y, Liu C-c, Ye J, Zhou B
Journal of virology 2024 Sep 17;98(9):e0063524
Journal of virology 2024 Sep 17;98(9):e0063524
Novel Dual PPAR δ/γ Partial Agonist Induces Hepatic Lipid Accumulation through Direct Binding and Inhibition of AKT1 Phosphorylation, Mediating CD36 Upregulation.
Cai X, Zhang Q, Wang J, Miao Y, Sun Y, Xia Z, Zhang L, Yu Q, Jiang Z
Chemical research in toxicology 2024 Sep 16;37(9):1574-1587
Chemical research in toxicology 2024 Sep 16;37(9):1574-1587
Compound heterozygous RYR1-RM mouse model reveals disease pathomechanisms and muscle adaptations to promote postnatal survival.
Liang C, Malik S, He M, Groom L, Ture SK, O'Connor TN, Morrell CN, Dirksen RT
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Oct;38(20):e70120
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Oct;38(20):e70120
Exploring the Effects of Whole Food-Based Dragon Fruit on Metabolic Disorders in High-Fat Diet-Induced Mice.
Ho PY, Lin PX, Koh YC, Lin WS, Tang KL, Chen YH, Weerawatanakorn M, Pan MH
Molecular nutrition & food research 2024 Nov;68(21):e2400604
Molecular nutrition & food research 2024 Nov;68(21):e2400604
A Mix of Probiotic Strains Prevents Hepatic Steatosis, and Improves Oxidative Stress Status and Gut Microbiota Composition in Obese Mice.
Guo C, He S, Le Barz M, Binda S, Wang H
Molecular nutrition & food research 2024 Nov;68(21):e2300672
Molecular nutrition & food research 2024 Nov;68(21):e2300672
Metformin suppresses metabolic dysfunction-associated fatty liver disease by ferroptosis and apoptosis via activation of oxidative stress.
Li Z, Cui C, Xu L, Ding M, Wang Y
Free radical research 2024 Nov;58(11):686-701
Free radical research 2024 Nov;58(11):686-701
Transcriptional Regulation of De Novo Lipogenesis by SIX1 in Liver Cancer Cells.
Li L, Zhang X, Xu G, Xue R, Li S, Wu S, Yang Y, Lin Y, Lin J, Liu G, Gao S, Zhang Y, Ye Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(41):e2404229
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(41):e2404229
NAT10 promotes liver lipogenesis in mouse through N4-acetylcytidine modification of Srebf1 and Scap mRNA.
Wang Z, Wan X, Khan MA, Peng L, Sun X, Yi X, Chen K
Lipids in health and disease 2024 Nov 11;23(1):368
Lipids in health and disease 2024 Nov 11;23(1):368
Probiotic-fermented tomato with hepatic lipid metabolism modulation effects: analysis of physicochemical properties, bioactivities, and potential bioactive compounds.
Wei B, Zheng W, Peng Z, Xiao M, Huang T, Xie M, Xiong T
Food & function 2024 May 7;15(9):4874-4886
Food & function 2024 May 7;15(9):4874-4886
Effect of LncRNA LOC106505926 on myogenesis and Lipogenesis of porcine primary cells.
Shi M, Yang S, Zhao X, Sun D, Li Y, Yang J, Li M, Cai C, Guo X, Li B, Lu C, Cao G
BMC genomics 2024 May 30;25(1):530
BMC genomics 2024 May 30;25(1):530
Ficolin 3 promotes ferroptosis in HCC by downregulating IR/SREBP axis-mediated MUFA synthesis.
Yuan Y, Xu J, Jiang Q, Yang C, Wang N, Liu X, Piao HL, Lu S, Zhang X, Han L, Liu Z, Cai J, Liu F, Chen S, Liu J
Journal of experimental & clinical cancer research : CR 2024 May 3;43(1):133
Journal of experimental & clinical cancer research : CR 2024 May 3;43(1):133
DPP3 promotes breast cancer tumorigenesis by stabilizing FASN and promoting lipid synthesis.
Fu X, Li X, Wang W, Li J
Acta biochimica et biophysica Sinica 2024 May 25;56(5):805-818
Acta biochimica et biophysica Sinica 2024 May 25;56(5):805-818
SIRT2-mediated deacetylation of ACLY promotes the progression of oesophageal squamous cell carcinoma.
Zhang X, Xu Y, Li S, Qin Y, Zhu G, Zhang Q, Zhang Y, Guan F, Fan T, Liu H
Journal of cellular and molecular medicine 2024 Mar;28(6):e18129
Journal of cellular and molecular medicine 2024 Mar;28(6):e18129
GSTM3 enhances radiosensitivity of nasopharyngeal carcinoma by promoting radiation-induced ferroptosis through USP14/FASN axis and GPX4.
Chen Y, Feng Y, Lin Y, Zhou X, Wang L, Zhou Y, Lin K, Cai L
British journal of cancer 2024 Mar;130(5):755-768
British journal of cancer 2024 Mar;130(5):755-768
Transcriptional and metabolic effects of aspartate-glutamate carrier isoform 1 (AGC1) downregulation in mouse oligodendrocyte precursor cells (OPCs).
Balboni N, Babini G, Poeta E, Protti M, Mercolini L, Magnifico MC, Barile SN, Massenzio F, Pignataro A, Giorgi FM, Lasorsa FM, Monti B
Cellular & molecular biology letters 2024 Mar 29;29(1):44
Cellular & molecular biology letters 2024 Mar 29;29(1):44
Lipid droplet accumulation in Wdr45-deficient cells caused by impairment of chaperone-mediated autophagic degradation of Fasn.
Xiong Q, Sun H, Wang Y, Xu Q, Zhang Y, Xu M, Zhao Z, Li P, Wu C
Lipids in health and disease 2024 Mar 28;23(1):91
Lipids in health and disease 2024 Mar 28;23(1):91
Integrating transcriptomics and network pharmacology to reveal the mechanisms of total Rhizoma Coptidis alkaloids against nonalcoholic steatohepatitis.
Li J, Ma Z, Yang Z, Yang M, Li C, Li M, Li X, Chen X, Ma H, Chen W, Ye X, Li X
Journal of ethnopharmacology 2024 Mar 25;322:117600
Journal of ethnopharmacology 2024 Mar 25;322:117600
Mechanistic of AMPK/ACC2 regulating myoblast differentiation by fatty acid oxidation of goat.
Kang Z, Zhang Z, Li J, Deng K, Wang F, Fan Y
International journal of biological macromolecules 2024 Jun;270(Pt 2):132243
International journal of biological macromolecules 2024 Jun;270(Pt 2):132243
Effects of endurance training under calorie restriction on energy substrate metabolism in mouse skeletal muscle and liver.
Takahashi K, Kitaoka Y, Hatta H
The journal of physiological sciences : JPS 2024 Jun 7;74(1):32
The journal of physiological sciences : JPS 2024 Jun 7;74(1):32
ROS Induced by Aphrocallistes vastus Lectin Enhance Oncolytic Vaccinia Virus Replication and Induce Apoptosis in Hepatocellular Carcinoma Cells.
Zhang Y, Zhu Y, Jiang G, Chen K, Zhang G, Chen K, Ye T, Zhou Y, Li G
Marine drugs 2024 Jun 30;22(7)
Marine drugs 2024 Jun 30;22(7)
Bruceine A alleviates alcoholic liver disease by inhibiting AIM2 inflammasome activation via activating FXR.
Li L, Xu S, Wang W, Li X, Wang H, Yang Q, Wang C, Gu J, Luo H, Meng Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155693
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155693
Lactobacillus rhamnosus 069 and Lactobacillus brevis 031: Unraveling Strain-Specific Pathways for Modulating Lipid Metabolism and Attenuating High-Fat-Diet-Induced Obesity in Mice.
Ho PY, Chou YC, Koh YC, Lin WS, Chen WJ, Tseng AL, Gung CL, Wei YS, Pan MH
ACS omega 2024 Jul 2;9(26):28520-28533
ACS omega 2024 Jul 2;9(26):28520-28533
Insulin receptor isoform B is required for efficient proinsulin processing in pancreatic β cells.
Jiang M, Wang N, Zhang Y, Zhang J, Li Y, Yan X, Zhang H, Li C, Guan Y, Liang B, Zhang W, Wu Y
iScience 2024 Jul 19;27(7):110017
iScience 2024 Jul 19;27(7):110017
The effect and mechanism of combined exposure of MC-LR and NaNO(2) on liver lipid metabolism.
Yang J, Zhang Z, Du X, Wang Y, Meng R, Ge K, Wu C, Liang X, Zhang H, Guo H
Environmental research 2024 Jul 1;252(Pt 4):119113
Environmental research 2024 Jul 1;252(Pt 4):119113
Time-restricted feeding ameliorates non-alcoholic fatty liver disease through modulating hepatic nicotinamide metabolism via gut microbiota remodeling.
Feng R, Yang W, Feng W, Huang X, Cen M, Peng G, Wu W, Wang Z, Jing Y, Long T, Liu Y, Li Z, Chang G, Huang K
Gut microbes 2024 Jan-Dec;16(1):2390164
Gut microbes 2024 Jan-Dec;16(1):2390164
PITPNC1 Suppress CD8(+) T cell immune function and promote radioresistance in rectal cancer by modulating FASN/CD155.
Liang J, Liao L, Xie L, Tang W, Yu X, Lu Y, Chen H, Xu J, Sun L, Wu H, Cui C, Tan Y
Journal of translational medicine 2024 Jan 30;22(1):117
Journal of translational medicine 2024 Jan 30;22(1):117
Prepared Radix Polygoni Multiflori and emodin alleviate lipid droplet accumulation in nonalcoholic fatty liver disease through MAPK signaling pathway inhibition.
Huang C, Zhang Y, Xu Y, Wei S, Yang T, Wang S, Li C, Lin H, Li X, Zhao S, Zhu L, Pan W
Aging 2024 Jan 26;16(3):2362-2384
Aging 2024 Jan 26;16(3):2362-2384
LncRNA Gm28382 promotes lipogenesis by interacting with miR-326-3p to regulate ChREBP signaling pathway in NAFLD.
Yang S, Zhang Y, Zhang Y, Yin L, Han X, Zhao X, Wang N, Xu L
International immunopharmacology 2024 Jan 25;127:111444
International immunopharmacology 2024 Jan 25;127:111444
TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis.
Hao XL, Lv YF, Li DF, Bai FH, Gong J, Pan GQ, Su LX, Wang YL, Fu WL, Liu B, Huang L, Yan D, Tan QL, Liu JY, Guo QN
Journal of translational medicine 2024 Jan 2;22(1):6
Journal of translational medicine 2024 Jan 2;22(1):6
A nanoemulsion targeting adipose hypertrophy and hyperplasia shows anti-obesity efficiency in female mice.
Lu Y, Luo Z, Zhou H, Shi Y, Zhu Y, Guo X, Huang J, Zhang J, Liu X, Wang S, Shan X, Yin H, Du Y, Li Q, You J, Luo L
Nature communications 2024 Jan 2;15(1):72
Nature communications 2024 Jan 2;15(1):72
Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease.
Dong J, Chen L, Ye F, Tang J, Liu B, Lin J, Zhou PH, Lu B, Wu M, Lu JH, He JJ, Engelender S, Meng Q, Song Z, He H
Nature communications 2024 Jan 2;15(1):168
Nature communications 2024 Jan 2;15(1):168
Metabolic reprogramming based on RNA sequencing of gemcitabine-resistant cells reveals the FASN gene as a therapeutic for bladder cancer.
Zhou L, Du K, Dai Y, Zeng Y, Luo Y, Ren M, Pan W, Liu Y, Zhang L, Zhu R, Feng D, Tian F, Gu C
Journal of translational medicine 2024 Jan 13;22(1):55
Journal of translational medicine 2024 Jan 13;22(1):55
Acetyl-CoA synthetase 2 promotes diabetic renal tubular injury in mice by rewiring fatty acid metabolism through SIRT1/ChREBP pathway.
Lu J, Li XQ, Chen PP, Zhang JX, Li L, Wang GH, Liu XQ, Jiang CM, Ma KL
Acta pharmacologica Sinica 2024 Feb;45(2):366-377
Acta pharmacologica Sinica 2024 Feb;45(2):366-377
Hypoxia induced cell dormancy of salivary adenoid cystic carcinoma through miR-922/DEC2 axis.
Dai L, Xian H, Wang H, Li M, Zhang M, Liang XH, Tang YL
Translational oncology 2024 Feb;40:101868
Translational oncology 2024 Feb;40:101868
Farnesoid X receptor overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in nonalcoholic fatty liver disease.
Xu S, Kong L, Li L, Wang C, Gu J, Luo H, Meng Q
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166930
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166930
FXR overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in alcoholic liver disease.
Li L, Kong L, Xu S, Wang C, Gu J, Luo H, Meng Q
Hepatology international 2024 Feb;18(1):188-205
Hepatology international 2024 Feb;18(1):188-205
Ginsenoside Rg5 inhibits lipid accumulation and hepatocyte apoptosis via the Notch1 signaling pathway in NASH mice.
Li N, Zhu C, Fu R, Ma X, Duan Z, Fan D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155287
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155287
Metastatic effects of perfluorooctanoic acid (PFOA) on Drosophila melanogaster with metabolic reprogramming and dysrhythmia in a multigenerational exposure scenario.
Fangninou FF, Yu Z, Li W, Xue L, Yin D
The Science of the total environment 2024 Feb 20;912:169305
The Science of the total environment 2024 Feb 20;912:169305
Topical rhubarb charcoal-crosslinked chitosan/silk fibroin sponge scaffold for the repair of diabetic ulcers improves hepatic lipid deposition in db/db mice via the AMPK signalling pathway.
Tan Q, He Q, Peng Z, Zeng X, Liu Y, Li D, Wang S, Wang J
Lipids in health and disease 2024 Feb 20;23(1):52
Lipids in health and disease 2024 Feb 20;23(1):52
SHMT2 reduces fatty liver but is necessary for liver inflammation and fibrosis in mice.
Chen G, Zhou G, Zhai L, Bao X, Tiwari N, Li J, Mottillo E, Wang J
Communications biology 2024 Feb 12;7(1):173
Communications biology 2024 Feb 12;7(1):173
Geniposide alleviates heart failure with preserved ejection fraction in mice by regulating cardiac oxidative stress via MMP2/SIRT1/GSK3β pathway.
Han YL, Yan TT, Li HX, Chen SS, Zhang ZZ, Wang MY, Chen MJ, Chen YL, Yang XX, Wei LL, Duan YJ, Zhang S
Acta pharmacologica Sinica 2024 Dec;45(12):2567-2578
Acta pharmacologica Sinica 2024 Dec;45(12):2567-2578
Spatial multi-omics characterizes GPR35-relevant lipid metabolism signatures across liver zonation in MASLD.
Otkur W, Zhang Y, Li Y, Bao W, Feng T, Wu B, Ma Y, Shi J, Wang L, Pei S, Wang W, Wang J, Zhao Y, Liu Y, Li X, Xia T, Wang F, Chen D, Liang X, Piao HL
Life metabolism 2024 Dec;3(6):loae021
Life metabolism 2024 Dec;3(6):loae021
Pharmacological inhibition of SREBP1 suppresses pancreatic cancer growth via inducing GPX4-mediated ferroptosis.
Cao R, Feng Z, Mo J, Wu J, Li J, Li W, Wang Z, Ma Q, Wu Z, Zhou C
Cellular signalling 2024 Dec;124:111381
Cellular signalling 2024 Dec;124:111381
FASN contributes to ADM resistance of diffuse large B-cell lymphoma by inhibiting ferroptosis via nf-κB/STAT3/GPX4 axis.
Zhong X, Zhang W, Zhang W, Yu N, Li W, Song X
Cancer biology & therapy 2024 Dec 31;25(1):2403197
Cancer biology & therapy 2024 Dec 31;25(1):2403197
Lipid droplet formation induced by icaritin derivative IC2 promotes a combination strategy for cancer therapy.
Wu G, Ying L, Zhang Q, Xiong H, Wang J, Chen S, Yang C, Jin Y, Lai Z, Feng N, Ge Y
Chinese medicine 2024 Dec 26;19(1):178
Chinese medicine 2024 Dec 26;19(1):178
Neutrophil extracellular traps in rheumatoid arthritis: Activating fibroblast-like synoviocytes via ATP citrate lyase.
Li J, Wang X, Tan M, Zheng J, Mao J, Hao J, Shen H
International immunopharmacology 2024 Dec 25;143(Pt 3):113518
International immunopharmacology 2024 Dec 25;143(Pt 3):113518
ZDHHC20 mediated S-palmitoylation of fatty acid synthase (FASN) promotes hepatocarcinogenesis.
Mo Y, Han Y, Chen Y, Fu C, Li Q, Liu Z, Xiao M, Xu B
Molecular cancer 2024 Dec 19;23(1):274
Molecular cancer 2024 Dec 19;23(1):274
Hepatoprotective effect of dietary pterostilbene against high-fat-diet-induced lipid accumulation exacerbated by chronic jet lag via SIRT1 and SIRT3 activation.
Koh YC, Yao CH, Lee PS, Nagabhushanam K, Ho CT, Pan MH
Phytotherapy research : PTR 2024 Aug;38(8):4099-4113
Phytotherapy research : PTR 2024 Aug;38(8):4099-4113
C9orf72 controls hepatic lipid metabolism by regulating SREBP1 transport.
Wu Y, Zheng W, Xu G, Zhu L, Li Z, Chen J, Wang L, Chen S
Cell death and differentiation 2024 Aug;31(8):1070-1084
Cell death and differentiation 2024 Aug;31(8):1070-1084
miR-218-5p promotes hepatic lipogenesis through targeting Elovl5 in non-alcoholic fatty liver disease.
Wu G, Zhang Y, Liang B, Yin L, Gao M, Zhang H, Xu Y, Han X, Qi Y, Liu F, Xu L
Biochemical pharmacology 2024 Aug;226:116411
Biochemical pharmacology 2024 Aug;226:116411
CD9 Counteracts Liver Steatosis and Mediates GCGR Agonist Hepatic Effects.
Zheng Y, Wang Y, Xiong X, Zhang L, Zhu J, Huang B, Liu X, Liu J, Zhu Z, Yang G, Qu H, Zheng H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(29):e2400819
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(29):e2400819
Berberine alleviates high-energy and low-protein diet-induced fatty liver hemorrhagic syndrome in laying hens: insights from microbiome and metabolomics.
Cheng X, Hu Y, Kuang J, Guo X, Cao H, Wu H, Hu G, Zhuang Y
Poultry science 2024 Aug;103(8):103968
Poultry science 2024 Aug;103(8):103968
Regulatory effect of β-glucan secreted by Rhizobium pusense on triglyceride metabolism and their relationships with the modulation of intestinal microbiota in mice fed a high-fat diet.
Zhang B, Zhao W, Song D, Lyu X
Food & function 2024 Aug 27;15(17):8759-8774
Food & function 2024 Aug 27;15(17):8759-8774
circNDUFA13 stimulates adipogenesis of bone marrow-derived mesenchymal stem cells via interaction with STAT3.
Huang L, He S, Wang T, Long K, Ma B, Wu P, Gong Y, Zhong D, Yang Q, Wu J, Li X
Scientific reports 2024 Aug 26;14(1):19787
Scientific reports 2024 Aug 26;14(1):19787
Lipid synthesis, triggered by PPARγ T166 dephosphorylation, sustains reparative function of macrophages during tissue repair.
Zuo S, Wang Y, Bao H, Zhang Z, Yang N, Jia M, Zhang Q, Jian A, Ji R, Zhang L, Lu Y, Huang Y, Shen P
Nature communications 2024 Aug 23;15(1):7269
Nature communications 2024 Aug 23;15(1):7269
Modulatory Effects of Lactobacillus paracasei-Fermented Turmeric on Metabolic Dysregulation and Gut Microbiota in High-Fat Diet-Induced Obesity in Mice.
Lin WS, Hwang SE, Koh YC, Ho PY, Pan MH
Journal of agricultural and food chemistry 2024 Aug 14;72(32):17924-17937
Journal of agricultural and food chemistry 2024 Aug 14;72(32):17924-17937
Voluntary Wheel Running Reduces Cardiometabolic Risks in Female Offspring Exposed to Lifelong High-Fat, High-Sucrose Diet.
Gonzalez K, Merlin AC, Roye E, Ju B, Lee Y, Chicco AJ, Chung E
Medicine and science in sports and exercise 2024 Aug 1;56(8):1378-1389
Medicine and science in sports and exercise 2024 Aug 1;56(8):1378-1389
Rutin ameliorated lipid metabolism dysfunction of diabetic NAFLD via AMPK/SREBP1 pathway.
Liu Y, Sun Z, Dong R, Liu P, Zhang X, Li Y, Lai X, Cheong HF, Wu Y, Wang Y, Zhou H, Gui D, Xu Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155437
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155437
Sodium butyrate alleviates free fatty acid-induced steatosis in primary chicken hepatocytes via the AMPK/PPARα pathway.
Ding J, Liu J, Chen J, Cheng X, Cao H, Guo X, Hu G, Zhuang Y
Poultry science 2024 Apr;103(4):103482
Poultry science 2024 Apr;103(4):103482
PPARγ alleviates preeclampsia development by regulating lipid metabolism and ferroptosis.
Lai W, Yu L, Deng Y
Communications biology 2024 Apr 9;7(1):429
Communications biology 2024 Apr 9;7(1):429
Hepatocyte-Specific PEX16 Abrogation in Mice Leads to Hepatocyte Proliferation, Alteration of Hepatic Lipid Metabolism, and Resistance to High-Fat Diet (HFD)-Induced Hepatic Steatosis and Obesity.
Chen X, Wang L, Denning KL, Mazur A, Xu Y, Wang K, Lawrence LM, Wang X, Lu Y
Biomedicines 2024 Apr 30;12(5)
Biomedicines 2024 Apr 30;12(5)
Herpetrione, a New Type of PPARα Ligand as a Therapeutic Strategy Against Nonalcoholic Steatohepatitis.
Linghu L, Zong W, Liao Y, Chen Q, Meng F, Wang G, Liao Z, Lan X, Chen M
Research (Washington, D.C.) 2023;6:0276
Research (Washington, D.C.) 2023;6:0276
Differences in histomorphology and expression of key lipid regulated genes of four adipose tissues from Tibetan pigs.
Lin C, Dong Z, Song J, Wang S, Yang Y, Li H, Feng Z, Pei Y
PeerJ 2023;11:e14556
PeerJ 2023;11:e14556
Sphingomyelin synthase-related protein SMSr is a phosphatidylethanolamine phospholipase C that promotes nonalcoholic fatty liver disease.
Chiang YP, Li Z, He M, Jones Q, Pan M, Han X, Jiang XC
The Journal of biological chemistry 2023 Sep;299(9):105162
The Journal of biological chemistry 2023 Sep;299(9):105162
miR-32-5p induces hepatic steatosis and hyperlipidemia by triggering de novo lipogenesis.
Wang YD, Wu LL, Mai YN, Wang K, Tang Y, Wang QY, Li JY, Jiang LY, Liao ZZ, Hu C, Wang YY, Liu JJ, Liu JH, Xiao XH
Metabolism: clinical and experimental 2023 Sep;146:155660
Metabolism: clinical and experimental 2023 Sep;146:155660
Metabolic characteristics of voriconazole - Induced liver injury in rats.
Du Q, Teng M, Yang L, Meng C, Qiu Y, Wang C, Chen J, Wang T, Chen S, Luo Y, Sun J, Dong Y
Chemico-biological interactions 2023 Sep 25;383:110693
Chemico-biological interactions 2023 Sep 25;383:110693
BCKDHA contributes to melanoma progression by promoting the expressions of lipogenic enzymes FASN and ACLY.
Tian Y, Ma J, Wang M, Yi X, Guo S, Wang H, Zhang H, Wang H, Yang Y, Zhang B, Du J, Shi Q, Gao T, Li C, Guo W
Experimental dermatology 2023 Oct;32(10):1633-1643
Experimental dermatology 2023 Oct;32(10):1633-1643
Long-term and liver-selected ginsenoside C-K nanoparticles retard NAFLD progression by restoring lipid homeostasis.
Yue C, Li D, Fan S, Tao F, Yu Y, Lu W, Chen Q, Yuan A, Wu J, Zhao G, Dong H, Hu Y
Biomaterials 2023 Oct;301:122291
Biomaterials 2023 Oct;301:122291
Cullin-associated and neddylation-dissociated 1 regulate reprogramming of lipid metabolism through SKP1-Cullin-1-F-box(FBXO11) -mediated heterogeneous nuclear ribonucleoprotein A2/B1 ubiquitination and promote hepatocellular carcinoma.
Zhang H, Xia P, Yang Z, Liu J, Zhu Y, Huang Z, Zhang Z, Yuan Y
Clinical and translational medicine 2023 Oct;13(10):e1443
Clinical and translational medicine 2023 Oct;13(10):e1443
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
Song K, Sun H, Tu B, Zhou Y, Lin LC, Liu ZY, Li R, Yang JJ, Zhang Y, Zhao JY, Tao H
iScience 2023 Oct 20;26(10):107931
iScience 2023 Oct 20;26(10):107931
Sex differences in FASN protein concentrations in urinary exosomes related to serum triglycerides levels in healthy adults.
Li T, Meng W, Liu TC, Wang YZ, Zhang M
Lipids in health and disease 2023 Oct 19;22(1):176
Lipids in health and disease 2023 Oct 19;22(1):176
E3 ubiquitin ligase Siah1 aggravates NAFLD through Scp2 ubiquitination.
Zhu Z, Hu X, Liu K, Li J, Fan K, Wang H, Wang L, He L, Ma Y, Guan R, Wang Z
International immunopharmacology 2023 Nov;124(Pt A):110897
International immunopharmacology 2023 Nov;124(Pt A):110897
High dietary fructose promotes hepatocellular carcinoma progression by enhancing O-GlcNAcylation via microbiota-derived acetate.
Zhou P, Chang WY, Gong DA, Xia J, Chen W, Huang LY, Liu R, Liu Y, Chen C, Wang K, Tang N, Huang AL
Cell metabolism 2023 Nov 7;35(11):1961-1975.e6
Cell metabolism 2023 Nov 7;35(11):1961-1975.e6
A bacteria-derived tetramerized protein ameliorates nonalcoholic steatohepatitis in mice via binding and relocating acetyl-coA carboxylase.
Lin Y, Yang M, Huang L, Yang F, Fan J, Qiang Y, Chang Y, Zhou W, Yan L, Xiong J, Ping J, Chen S, Men D, Li F
Cell reports 2023 Nov 28;42(11):113453
Cell reports 2023 Nov 28;42(11):113453
Resensitizing Paclitaxel-Resistant Ovarian Cancer via Targeting Lipid Metabolism Key Enzymes CPT1A, SCD and FASN.
Ma Q, Liu Z, Wang T, Zhao P, Liu M, Wang Y, Zhao W, Yuan Y, Li S
International journal of molecular sciences 2023 Nov 19;24(22)
International journal of molecular sciences 2023 Nov 19;24(22)
MiR-337-3p improves metabolic-associated fatty liver disease through regulation of glycolipid metabolism.
Xu X, Yu C, He H, Pan X, Hou A, Feng J, Tan R, Gong L, Chen J, Ren J
iScience 2023 Nov 17;26(11):108352
iScience 2023 Nov 17;26(11):108352
TRPV4 enhances the synthesis of fatty acids to drive the progression of ovarian cancer through the calcium-mTORC1/SREBP1 signaling pathway.
Lin L, Li X, Wu AJ, Xiu JB, Gan YZ, Yang XM, Ai ZH
iScience 2023 Nov 17;26(11):108226
iScience 2023 Nov 17;26(11):108226
Inhibiting Phosphatidylcholine Remodeling in Adipose Tissue Increases Insulin Sensitivity.
He M, Li Z, Tung VSK, Pan M, Han X, Evgrafov O, Jiang XC
Diabetes 2023 Nov 1;72(11):1547-1559
Diabetes 2023 Nov 1;72(11):1547-1559
Enhancement of PPARα-Inhibited Leucine Metabolism-Stimulated β-Casein Synthesis and Fatty Acid Synthesis in Primary Bovine Mammary Epithelial Cells.
Huang J, Li J, Ning Y, Ren Y, Shao Y, Zhang H, Zong X, Shi H
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16184-16193
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16184-16193
TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN.
Zhang K, Yang C, Zhou X, Liang J, Guo J, Li M, Zhang Y, Shao S, Sun P, Li K, Huang J, Chen F, Liang X, Su D
Cellular and molecular life sciences : CMLS 2023 May 30;80(6):168
Cellular and molecular life sciences : CMLS 2023 May 30;80(6):168
Dedifferentiated fat cells administration ameliorates abnormal expressions of fatty acids metabolism-related protein expressions and intestinal tissue damage in experimental necrotizing enterocolitis.
Mimatsu H, Onoda A, Kazama T, Nishijima K, Shimoyama Y, Go S, Ueda K, Takahashi Y, Matsumoto T, Hayakawa M, Sato Y
Scientific reports 2023 May 22;13(1):8266
Scientific reports 2023 May 22;13(1):8266
Insoluble Dietary Fiber from Soybean Residue (Okara) Exerts Anti-Obesity Effects by Promoting Hepatic Mitochondrial Fatty Acid Oxidation.
Zhang J, Wang S, Wang J, Liu W, Gong H, Zhang Z, Lyu B, Yu H
Foods (Basel, Switzerland) 2023 May 22;12(10)
Foods (Basel, Switzerland) 2023 May 22;12(10)
Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR-7/m-TOR/SREBP1 pathway on prostate cancer.
Xu W, Ding J, Li B, Sun T, You X, He Q, Sheng W
BioFactors (Oxford, England) 2023 Mar;49(2):438-456
BioFactors (Oxford, England) 2023 Mar;49(2):438-456
Developmental changes in lipid and fatty acid metabolism and the inhibition by in ovo feeding oleic acid in Muscovy duck embryogenesis.
Zhang X, Wu Q, Zheng W, Liu C, Huang L, Zuo X, Xiao W, Han X, Ye H, Wang W, Yang L, Zhu Y
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2023 Mar;12:321-333
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2023 Mar;12:321-333
Gamma-Muricholic Acid Inhibits Nonalcoholic Steatohepatitis: Abolishment of Steatosis-Dependent Peroxidative Impairment by FXR/SHP/LXRα/FASN Signaling.
Xie Y, Shen F, He Y, Guo C, Yang R, Cao H, Pan Q, Fan J
Nutrients 2023 Mar 2;15(5)
Nutrients 2023 Mar 2;15(5)
Docosahexaenoic Acid Alters Lipid Metabolism Processes via H3K9ac Epigenetic Modification in Dairy Goat.
Wu J, Luo J, He Q, Xia Y, Tian H, Zhu L, Li C, Loor JJ
Journal of agricultural and food chemistry 2023 Jun 7;71(22):8527-8539
Journal of agricultural and food chemistry 2023 Jun 7;71(22):8527-8539
Differential Inhibition of Anaplerotic Pyruvate Carboxylation and Glutaminolysis-Fueled Anabolism Underlies Distinct Toxicity of Selenium Agents in Human Lung Cancer.
Fan TW, Winnike J, Al-Attar A, Belshoff AC, Lorkiewicz PK, Tan JL, Wu M, Higashi RM, Lane AN
Metabolites 2023 Jun 21;13(7)
Metabolites 2023 Jun 21;13(7)
Long noncoding RNAs with peptide-encoding potential identified in esophageal squamous cell carcinoma: KDM4A-AS1-encoded peptide weakens cancer cell viability and migratory capacity.
Zhou B, Wu Y, Cheng P, Wu C
Molecular oncology 2023 Jul;17(7):1419-1436
Molecular oncology 2023 Jul;17(7):1419-1436
Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1/2-PPARγ-Cd36 pathway.
Li L, Sun H, Chen J, Ding C, Yang X, Han H, Sun Q
Cell reports 2023 Jul 25;42(7):112697
Cell reports 2023 Jul 25;42(7):112697
Imbalance in ALR ubiquitination accelerates the progression of nonalcoholic steatohepatitis to hepatocellular carcinoma.
Zheng M, Ai Z, Guo Y, Chen Y, Xie P, An W
Oncogene 2023 Jan;42(4):308-321
Oncogene 2023 Jan;42(4):308-321
TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability.
Chen X, Yong H, Chen M, Deng C, Wang P, Chu S, Li M, Hou P, Zheng J, Li Z, Bai J
Journal of experimental & clinical cancer research : CR 2023 Jan 25;42(1):34
Journal of experimental & clinical cancer research : CR 2023 Jan 25;42(1):34
Enhanced De Novo Lipid Synthesis Mediated by FASN Induces Chemoresistance in Colorectal Cancer.
Han L, Dai W, Luo W, Ye L, Fang H, Mo S, Li Q, Xu Y, Wang R, Cai G
Cancers 2023 Jan 17;15(3)
Cancers 2023 Jan 17;15(3)
LncRNA-TBP mediates TATA-binding protein recruitment to regulate myogenesis and induce slow-twitch myofibers.
Ma M, Cai B, Zhou Z, Kong S, Zhang J, Xu H, Zhang X, Nie Q
Cell communication and signaling : CCS 2023 Jan 12;21(1):7
Cell communication and signaling : CCS 2023 Jan 12;21(1):7
CircRNA MBOAT2 promotes intrahepatic cholangiocarcinoma progression and lipid metabolism reprogramming by stabilizing PTBP1 to facilitate FASN mRNA cytoplasmic export.
Yu X, Tong H, Chen J, Tang C, Wang S, Si Y, Wang S, Tang Z
Cell death & disease 2023 Jan 12;14(1):20
Cell death & disease 2023 Jan 12;14(1):20
Protein kinase C epsilon promotes de novo lipogenesis and tumor growth in prostate cancer cells by regulating the phosphorylation and nuclear translocation of pyruvate kinase isoform M2.
Lai X, Liang Y, Jin J, Zhang H, Wu Z, Li G, Wang J, Zhang Z, Chen H, Zeng F, Deng F
Experimental cell research 2023 Jan 1;422(1):113427
Experimental cell research 2023 Jan 1;422(1):113427
Knockout of ICAT in Adipose Tissue Alleviates Fibro-inflammation in Obese Mice.
Song Z, Liu N, He Y, Chen J, Li J, Wang F, Wu Z
Inflammation 2023 Feb;46(1):404-417
Inflammation 2023 Feb;46(1):404-417
Docosahexaenoic acid reverses PD-L1-mediated immune suppression by accelerating its ubiquitin-proteasome degradation.
Zhang H, Chen H, Yin S, Fan L, Jin C, Zhao C, Hu H
The Journal of nutritional biochemistry 2023 Feb;112:109186
The Journal of nutritional biochemistry 2023 Feb;112:109186
L-Theanine regulates lipid metabolism by modulating gut microbiota and bile acid metabolism.
Xu W, Kong Y, Zhang T, Gong Z, Xiao W
Journal of the science of food and agriculture 2023 Feb;103(3):1283-1293
Journal of the science of food and agriculture 2023 Feb;103(3):1283-1293
Vitamin D Receptor Activation Attenuates Olanzapine-Induced Dyslipidemia in Mice Through Alleviating Hepatic Endoplasmic Reticulum Stress.
Dang R, Wang J, Tang M, Han W, Jiang P
Advanced biology 2023 Dec;7(12):e2300228
Advanced biology 2023 Dec;7(12):e2300228
Foxk1 stimulates adipogenic differentiation via a peroxisome proliferator-activated receptor gamma 2-dependent mechanism.
Zhang S, You Y, Li Y, Yuan H, Zhou J, Tian L, Liu Y, Wang B, Zhu E
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23266
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23266
Expression profile of FASN gene and association of its polymorphisms with intramuscular fat content in Hu sheep.
Liu C, Liu X, Yuan Z, Zhang X, Li F, Yue X
Animal biotechnology 2023 Dec;34(9):4347-4356
Animal biotechnology 2023 Dec;34(9):4347-4356
F6P/G6P-mediated ChREBP activation promotes the insulin resistance-driven hepatic lipid deposition in zebrafish.
Gong Y, Lu Q, Xi L, Liu Y, Yang B, Su J, Liu H, Jin J, Zhang Z, Yang Y, Zhu X, Xie S, Han D
The Journal of nutritional biochemistry 2023 Dec;122:109452
The Journal of nutritional biochemistry 2023 Dec;122:109452
Lonicerae flos polysaccharides improve nonalcoholic fatty liver disease by activating the adenosine 5'-monophosphate-activated protein kinase pathway and reshaping gut microbiota.
Han C, Li Z, Liu R, Zhao Z, Wang Y, Zuo X, Zhang Y, Geng Z, Huang H, Pan X, Li W
Journal of the science of food and agriculture 2023 Dec;103(15):7721-7738
Journal of the science of food and agriculture 2023 Dec;103(15):7721-7738
Senescence-associated 13-HODE production promotes age-related liver steatosis by directly inhibiting catalase activity.
Duan J, Dong W, Wang G, Xiu W, Pu G, Xu J, Ye C, Zhang X, Zhu Y, Wang C
Nature communications 2023 Dec 9;14(1):8151
Nature communications 2023 Dec 9;14(1):8151
LncHLEF promotes hepatic lipid synthesis through miR-2188-3p/GATA6 axis and encoding peptides and enhances intramuscular fat deposition via exosome.
Guo Y, Tian W, Wang D, Yang L, Wang Z, Wu X, Zhi Y, Zhang K, Wang Y, Li Z, Jiang R, Sun G, Li G, Tian Y, Wang H, Kang X, Liu X, Li H
International journal of biological macromolecules 2023 Dec 31;253(Pt 5):127061
International journal of biological macromolecules 2023 Dec 31;253(Pt 5):127061
Therapeutic protein PAK restrains the progression of triple negative breast cancer through degrading SREBP-1 mRNA.
Hu P, Zhou P, Sun T, Liu D, Yin J, Liu L
Breast cancer research : BCR 2023 Dec 11;25(1):151
Breast cancer research : BCR 2023 Dec 11;25(1):151
α-Lactalbumin Peptide Asp-Gln-Trp Ameliorates Hepatic Steatosis and Oxidative Stress in Free Fatty Acids-Treated HepG2 Cells and High-Fat Diet-Induced NAFLD Mice by Activating the PPARα Pathway.
Chen H, Ma Y, Qi X, Tian J, Ma Y, Niu T
Molecular nutrition & food research 2023 Aug;67(16):e2200499
Molecular nutrition & food research 2023 Aug;67(16):e2200499
Decreased Imiquimod-Induced Psoriasis-Like Skin Inflammation in a Novel Mvd(F250S/+) Knock-In Mouse Model.
La Y, Wong W, Peng K, Tian Z, Pan J, Sun R, Luan J, Yan K, Zhang Q, Zhang Z
Inflammation 2023 Aug;46(4):1575-1586
Inflammation 2023 Aug;46(4):1575-1586
Integrated multi-omics analyses reveal Jorunnamycin A as a novel suppressor for muscle-invasive bladder cancer by targeting FASN and TOP1.
Chen R, Hao X, Chen J, Zhang C, Fan H, Lian F, Chen X, Wang C, Xia Y
Journal of translational medicine 2023 Aug 16;21(1):549
Journal of translational medicine 2023 Aug 16;21(1):549
Cordycepin reprogramming lipid metabolism to block metastasis and EMT via ERO1A/mTOR/SREBP1 axis in cholangiocarcinoma.
Zhou X, Li Y, Yang C, Chen D, Wang T, Liu T, Yan W, Su Z, Peng B, Ren X
Life sciences 2023 Aug 15;327:121698
Life sciences 2023 Aug 15;327:121698
Epiberberine regulates lipid synthesis through SHP (NR0B2) to improve non-alcoholic steatohepatitis.
Zhou LM, Fan JH, Xu MM, Xiong MY, Wang QJ, Chai X, Li XD, Li XG, Ye XL
Biochimica et biophysica acta. Molecular basis of disease 2023 Apr;1869(4):166639
Biochimica et biophysica acta. Molecular basis of disease 2023 Apr;1869(4):166639
Protopanaxadiol ameliorates NAFLD by regulating hepatocyte lipid metabolism through AMPK/SIRT1 signaling pathway.
Li Y, Liu Y, Chen Z, Tang K, Yang L, Jiang Y, Wang J, Huang P, Wang J, Zheng P, Song H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Apr;160:114319
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Apr;160:114319
Tandem mass tag-based quantitative proteomics analysis reveals the effects of the α-lactalbumin peptides GINY and DQW on lipid deposition and oxidative stress in HepG2 cells.
Chen H, Qi X, Guan K, Wang R, Li Q, Ma Y
Journal of dairy science 2023 Apr;106(4):2271-2288
Journal of dairy science 2023 Apr;106(4):2271-2288
A UPLC-Q-TOF/MS and network pharmacology method to explore the mechanism of Anhua fuzhuan tea intervention in nonalcoholic fatty liver disease.
Tian FM, Yi J, Tang Y, Chen BW, Long HP, Liu YF, Ou-Yang Y, Zhang WJ, Tang RM, Liu BY
Food & function 2023 Apr 24;14(8):3686-3700
Food & function 2023 Apr 24;14(8):3686-3700
DAXX drives de novo lipogenesis and contributes to tumorigenesis.
Mahmud I, Tian G, Wang J, Hutchinson TE, Kim BJ, Awasthee N, Hale S, Meng C, Moore A, Zhao L, Lewis JE, Waddell A, Wu S, Steger JM, Lydon ML, Chait A, Zhao LY, Ding H, Li JL, Purayil HT, Huo Z, Daaka Y, Garrett TJ, Liao D
Nature communications 2023 Apr 12;14(1):1927
Nature communications 2023 Apr 12;14(1):1927
MiR-328-5p inhibits the adipogenic differentiation of hMSCs by targeting fatty acid synthase.
Li X, He S, Wu P, Zhou Y, Long K, Wang T
Folia histochemica et cytobiologica 2022;60(4):292-300
Folia histochemica et cytobiologica 2022;60(4):292-300
Profile analysis and functional modeling identify circular RNAs in nonalcoholic fatty liver disease as regulators of hepatic lipid metabolism.
Xie Y, Cao Y, Guo CJ, Guo XY, He YF, Xu QY, Shen F, Pan Q
Frontiers in genetics 2022;13:884037
Frontiers in genetics 2022;13:884037
D-Mannose Regulates Hepatocyte Lipid Metabolism via PI3K/Akt/mTOR Signaling Pathway and Ameliorates Hepatic Steatosis in Alcoholic Liver Disease.
Hu M, Chen Y, Deng F, Chang B, Luo J, Dong L, Lu X, Zhang Y, Chen Z, Zhou J
Frontiers in immunology 2022;13:877650
Frontiers in immunology 2022;13:877650
Effects of Poria cocos extract on metabolic dysfunction-associated fatty liver disease via the FXR/PPARα-SREBPs pathway.
He J, Yang Y, Zhang F, Li Y, Li X, Pu X, He X, Zhang M, Yang X, Yu Q, Qi Y, Li X, Yu J
Frontiers in pharmacology 2022;13:1007274
Frontiers in pharmacology 2022;13:1007274
PRMT5 confers lipid metabolism reprogramming, tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours.
Yuan HF, Zhao M, Zhao LN, Yun HL, Yang G, Geng Y, Wang YF, Zheng W, Yuan Y, Song TQ, Niu JQ, Zhang XD
Acta pharmacologica Sinica 2022 Sep;43(9):2373-2385
Acta pharmacologica Sinica 2022 Sep;43(9):2373-2385
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.
Dai W, Xiang W, Han L, Yuan Z, Wang R, Ma Y, Yang Y, Cai S, Xu Y, Mo S, Li Q, Cai G
Cancer communications (London, England) 2022 Sep;42(9):848-867
Cancer communications (London, England) 2022 Sep;42(9):848-867
A therapeutic DC vaccine with maintained immunological activity exhibits robust anti-tumor efficacy.
Lu Y, Shi Y, Liu Y, Luo Z, Zhang J, Jiang M, Li X, Liu X, Guo X, Qin B, Yin H, Du Y, Qiu Y, Lou Y, Guan G, Luo L, You J
Journal of controlled release : official journal of the Controlled Release Society 2022 Sep;349:254-268
Journal of controlled release : official journal of the Controlled Release Society 2022 Sep;349:254-268
Metabolic Syndrome Ameliorated by 4-Methylesculetin by Reducing Hepatic Lipid Accumulation.
Li L, Zhu G, Fu G, Zha W, Li H
International journal of molecular sciences 2022 Sep 9;23(18)
International journal of molecular sciences 2022 Sep 9;23(18)
Super-enhancer-associated INSM2 regulates lipid metabolism by modulating mTOR signaling pathway in neuroblastoma.
Cao H, Zhuo R, Zhang Z, Wang J, Tao Y, Yang R, Guo X, Chen Y, Jia S, Yao Y, Yang P, Yu J, Jiao W, Li X, Fang F, Xie Y, Li G, Wu D, Wang H, Feng C, Xu Y, Li Z, Pan J, Wang J
Cell & bioscience 2022 Sep 16;12(1):158
Cell & bioscience 2022 Sep 16;12(1):158
The role of hepatic Surf4 in lipoprotein metabolism and the development of atherosclerosis in apoE(-/-) mice.
Shen Y, Gu HM, Zhai L, Wang B, Qin S, Zhang DW
Biochimica et biophysica acta. Molecular and cell biology of lipids 2022 Oct;1867(10):159196
Biochimica et biophysica acta. Molecular and cell biology of lipids 2022 Oct;1867(10):159196
Cerulenin suppresses ErbB2-overexpressing breast cancer by targeting ErbB2/PKM2 pathway.
Lv S, Zhang Y, Song J, Chen J, Huang B, Luo Y, Zhao Y
Medical oncology (Northwood, London, England) 2022 Oct 29;40(1):5
Medical oncology (Northwood, London, England) 2022 Oct 29;40(1):5
Derepression of the USP22-FASN axis by p53 loss under oxidative stress drives lipogenesis and tumorigenesis.
Han Z, Liu M, Xie Y, Zeng K, Zhan Z, Chen Y, Wang L, Chen X, Luo Y, Zeng Y, Zhan H, Lin Y, Zhang K, Zhu X, Liu S, Luo X, Zhou A
Cell death discovery 2022 Nov 4;8(1):445
Cell death discovery 2022 Nov 4;8(1):445
circPRKAA1 activates a Ku80/Ku70/SREBP-1 axis driving de novo fatty acid synthesis in cancer cells.
Li Q, Yao H, Wang Y, Wu Y, Thorne RF, Zhu Y, Wu M, Liu L
Cell reports 2022 Nov 22;41(8):111707
Cell reports 2022 Nov 22;41(8):111707
Obesity promotes lipid accumulation in lymph node metastasis of gastric cancer: a retrospective case‒control study.
Xiao J, Shen K, Liu K, Wang Y, Fan H, Cheng Q, Zhou X, Hu L, Wang G, Xu Z, Yang L
Lipids in health and disease 2022 Nov 17;21(1):123
Lipids in health and disease 2022 Nov 17;21(1):123
FASN promotes lymph node metastasis in cervical cancer via cholesterol reprogramming and lymphangiogenesis.
Du Q, Liu P, Zhang C, Liu T, Wang W, Shang C, Wu J, Liao Y, Chen Y, Huang J, Tan H, Zhao Y, Xia M, Liu J, Yao S
Cell death & disease 2022 May 21;13(5):488
Cell death & disease 2022 May 21;13(5):488
Dietary L-arginine supplementation of tilapia (Oreochromis niloticus) alters the microbial population and activates intestinal fatty acid oxidation.
Li S, Wang C, Wu Z
Amino acids 2022 Mar;54(3):339-351
Amino acids 2022 Mar;54(3):339-351
Effects of maternal feed intake restriction on the blood parameters, fatty acid profile and lipogenetic genes expression of perirenal fat in offspring kids.
Chen W, Yang H, Yan Q, Zhou X, Tan Z, Wang Z
Animal reproduction science 2022 Mar;238:106955
Animal reproduction science 2022 Mar;238:106955
Psoralen Suppresses Lipid Deposition by Alleviating Insulin Resistance and Promoting Autophagy in Oleate-Induced L02 Cells.
Wang Y, Wang Y, Li F, Zou J, Li X, Xu M, Yu D, Ma Y, Huang W, Sun X, Zhang Y
Cells 2022 Mar 22;11(7)
Cells 2022 Mar 22;11(7)
Novel phosphanegold(I) thiolate complexes suppress de novo lipid synthesis in human lung cancer.
Luo M, Ma X, Jiang W, Zhang J, Liu W, Wei S, Liu H
European journal of medicinal chemistry 2022 Mar 15;232:114168
European journal of medicinal chemistry 2022 Mar 15;232:114168
CRISPR/Cas9-Induced Knockout of miR-24 Reduces Cholesterol and Monounsaturated Fatty Acid Content in Primary Goat Mammary Epithelial Cells.
Huang L, Luo J, Gao W, Song N, Tian H, Zhu L, Jiang Q, Loor JJ
Foods (Basel, Switzerland) 2022 Jul 7;11(14)
Foods (Basel, Switzerland) 2022 Jul 7;11(14)
Quantitative proteomic analysis of Bi Zhong Xiao decoction against collagen-induced arthritis rats in the early and late stages.
He C, Wang Y, Wen Y, Li T, Hu E, Zeng S, Xiong X
BMC complementary medicine and therapies 2022 Jul 13;22(1):186
BMC complementary medicine and therapies 2022 Jul 13;22(1):186
Scutellarin ameliorates hepatic lipid accumulation by enhancing autophagy and suppressing IRE1α/XBP1 pathway.
Zhang X, Huo Z, Luan H, Huang Y, Shen Y, Sheng L, Liang J, Wu F
Phytotherapy research : PTR 2022 Jan;36(1):433-447
Phytotherapy research : PTR 2022 Jan;36(1):433-447
MicroRNA-377-3p inhibits hepatocellular carcinoma growth and metastasis through negative regulation of CPT1C-mediated fatty acid oxidation.
Zhang T, Zhang Y, Liu J, Ma Y, Ye Q, Yan X, Ding L
Cancer & metabolism 2022 Jan 20;10(1):2
Cancer & metabolism 2022 Jan 20;10(1):2
Ginsenoside CK ameliorates hepatic lipid accumulation via activating the LKB1/AMPK pathway in vitro and in vivo.
Zhang J, Ma X, Fan D
Food & function 2022 Feb 7;13(3):1153-1167
Food & function 2022 Feb 7;13(3):1153-1167
Protein C receptor maintains cancer stem cell properties via activating lipid synthesis in nasopharyngeal carcinoma.
Zhang P, He Q, Wang Y, Zhou G, Chen Y, Tang L, Zhang Y, Hong X, Mao Y, He Q, Yang X, Liu N, Ma J
Signal transduction and targeted therapy 2022 Feb 16;7(1):46
Signal transduction and targeted therapy 2022 Feb 16;7(1):46
TiO(2) nanosheets promote the transformation of vascular smooth muscle cells into foam cells in vitro and in vivo through the up-regulation of nuclear factor kappa B subunit 2.
Li S, Yan D, Huang C, Yang F, Cao Y
Journal of hazardous materials 2022 Feb 15;424(Pt D):127704
Journal of hazardous materials 2022 Feb 15;424(Pt D):127704
Polyphyllin I improves myocardial damage in coronary artery disease via modulating lipid metabolism and myocardial apoptosis.
Yang Z, Yang X, An M
Journal of biochemical and molecular toxicology 2022 Dec;36(12):e23219
Journal of biochemical and molecular toxicology 2022 Dec;36(12):e23219
Di-2-ethylhexyl phthalate-induced miR-155-5p promoted lipid metabolism via inhibiting cAMP/PKA signaling pathway in human trophoblastic HTR-8/Svneo cells.
Gu X, Liu H, Luo W, Wang X, Wang H, Li L
Reproductive toxicology (Elmsford, N.Y.) 2022 Dec;114:22-31
Reproductive toxicology (Elmsford, N.Y.) 2022 Dec;114:22-31
Loss of Mature Lamin A/C Triggers a Shift in Intracellular Metabolic Homeostasis via AMPKα Activation.
Zhou Y, Yang JJ, Cheng Y, Feng GX, Yang RH, Yuan Y, Wang LY, Wang M, Kong L
Cells 2022 Dec 9;11(24)
Cells 2022 Dec 9;11(24)
Microalgae oil from Schizochytrium sp. alleviates obesity and modulates gut microbiota in high-fat diet-fed mice.
Ran L, Yu J, Ma R, Yao Q, Wang M, Bi Y, Yu Z, Wu Y
Food & function 2022 Dec 13;13(24):12799-12813
Food & function 2022 Dec 13;13(24):12799-12813
Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion.
Wang JQ, Li LL, Hu A, Deng G, Wei J, Li YF, Liu YB, Lu XY, Qiu ZP, Shi XJ, Zhao X, Luo J, Song BL
Nature 2022 Aug;608(7922):413-420
Nature 2022 Aug;608(7922):413-420
MiR-103-3p promotes hepatic steatosis to aggravate nonalcoholic fatty liver disease by targeting of ACOX1.
Ding J, Xia C, Cen P, Li S, Yu L, Zhu J, Jin J
Molecular biology reports 2022 Aug;49(8):7297-7305
Molecular biology reports 2022 Aug;49(8):7297-7305
Salvia-Nelumbinis naturalis improves lipid metabolism of NAFLD by regulating the SIRT1/AMPK signaling pathway.
Liu Y, Li Y, Wang J, Yang L, Yu X, Huang P, Song H, Zheng P
BMC complementary medicine and therapies 2022 Aug 9;22(1):213
BMC complementary medicine and therapies 2022 Aug 9;22(1):213
Functionalized gadofullerene ameliorates impaired glycolipid metabolism in type 2 diabetic mice.
Wu J, Chen Y, Li X, Ran L, Liu X, Wang X, Zhen M, Shao S, Zeng L, Wang C, Liang B, Zhao J, Wu Y
Journal of genetics and genomics = Yi chuan xue bao 2022 Apr;49(4):364-376
Journal of genetics and genomics = Yi chuan xue bao 2022 Apr;49(4):364-376
Long noncoding RNA ZFP36L2-AS functions as a metabolic modulator to regulate muscle development.
Cai B, Ma M, Zhang J, Kong S, Zhou Z, Li Z, Abdalla BA, Xu H, Zhang X, Lawal RA, Nie Q
Cell death & disease 2022 Apr 21;13(4):389
Cell death & disease 2022 Apr 21;13(4):389
RNF8 up-regulates AR/ARV7 action to contribute to advanced prostate cancer progression.
Zhou T, Wang S, Song X, Liu W, Dong F, Huo Y, Zou R, Wang C, Zhang S, Liu W, Sun G, Lin L, Zeng K, Dong X, Guo Q, Yi F, Wang Z, Li X, Jiang B, Cao L, Zhao Y
Cell death & disease 2022 Apr 15;13(4):352
Cell death & disease 2022 Apr 15;13(4):352
LYAR Promotes Colorectal Cancer Progression by Upregulating FSCN1 Expression and Fatty Acid Metabolism.
Wu Y, Zhou Y, Gao H, Wang Y, Cheng Q, Jian S, Ding Q, Gu W, Yao Y, Ma J, Wu W, Li Y, Tong X, Song X, Ma S
Oxidative medicine and cellular longevity 2021;2021:9979707
Oxidative medicine and cellular longevity 2021;2021:9979707
The Mutual Inhibition of FoxO1 and SREBP-1c Regulated the Progression of Hepatoblastoma by Regulating Fatty Acid Metabolism.
Hu Y, Zai H, Jiang W, Ou Z, Yao Y, Zhu Q
Mediators of inflammation 2021;2021:5754592
Mediators of inflammation 2021;2021:5754592
PRPF6 promotes androgen receptor/androgen receptor-variant 7 actions in castration-resistant prostate cancer cells.
Liu W, Wang C, Wang S, Zeng K, Wei S, Sun N, Sun G, Wang M, Zou R, Liu W, Lin L, Song H, Jin Z, Zhao Y
International journal of biological sciences 2021;17(1):188-203
International journal of biological sciences 2021;17(1):188-203
SOAT1 Promotes Gastric Cancer Lymph Node Metastasis Through Lipid Synthesis.
Zhu T, Wang Z, Zou T, Xu L, Zhang S, Chen Y, Chen C, Zhang W, Wang S, Ding Q, Xu G
Frontiers in pharmacology 2021;12:769647
Frontiers in pharmacology 2021;12:769647
High-Salt Attenuates the Efficacy of Dapagliflozin in Tubular Protection by Impairing Fatty Acid Metabolism in Diabetic Kidney Disease.
Zou M, Chen Y, Zheng Z, Sheng S, Jia Y, Wang X, Ren S, Yang Y, Li X, Dong W, Guan M, Zhang Q, Xue Y
Frontiers in pharmacology 2021;12:741087
Frontiers in pharmacology 2021;12:741087
Pterostilbene attenuates RIPK3-dependent hepatocyte necroptosis in alcoholic liver disease via SIRT2-mediated NFATc4 deacetylation.
Shao Y, Wang X, Zhou Y, Jiang Y, Wu R, Lu C
Toxicology 2021 Sep;461:152923
Toxicology 2021 Sep;461:152923
Deficiency of intestinal Bmal1 prevents obesity induced by high-fat feeding.
Yu F, Wang Z, Zhang T, Chen X, Xu H, Wang F, Guo L, Chen M, Liu K, Wu B
Nature communications 2021 Sep 7;12(1):5323
Nature communications 2021 Sep 7;12(1):5323
Novel SREBP1 inhibitor cinobufotalin suppresses proliferation of hepatocellular carcinoma by targeting lipogenesis.
Meng H, Shen M, Li J, Zhang R, Li X, Zhao L, Huang G, Liu J
European journal of pharmacology 2021 Sep 5;906:174280
European journal of pharmacology 2021 Sep 5;906:174280
Comprehensive multi-omics approaches reveal the hepatotoxic mechanism of perfluorohexanoic acid (PFHxA) in mice.
Jiang L, Hong Y, Xie G, Zhang J, Zhang H, Cai Z
The Science of the total environment 2021 Oct 10;790:148160
The Science of the total environment 2021 Oct 10;790:148160
Exercise improves lipid metabolism disorders induced by high-fat diet in a SESN2/JNK-independent manner.
Wang T, Hu W, Niu Y, Liu S, Fu L
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2021 Nov;46(11):1322-1330
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2021 Nov;46(11):1322-1330
Changes of lipid profiles in human umbilical vein endothelial cells exposed to zirconia nanoparticles with or without the presence of free fatty acids.
Cheng X, Guo H, Xian Y, Xie X
Journal of applied toxicology : JAT 2021 May;41(5):765-774
Journal of applied toxicology : JAT 2021 May;41(5):765-774
Lipid metabolism regulator human hydroxysteroid dehydrogenase-like 2 (HSDL2) modulates cervical cancer cell proliferation and metastasis.
Yang Y, Han A, Wang X, Yin X, Cui M, Lin Z
Journal of cellular and molecular medicine 2021 May;25(10):4846-4859
Journal of cellular and molecular medicine 2021 May;25(10):4846-4859
Apple polyphenol extract alleviates lipid accumulation in free-fatty-acid-exposed HepG2 cells via activating autophagy mediated by SIRT1/AMPK signaling.
Li D, Cui Y, Wang X, Liu F, Li X
Phytotherapy research : PTR 2021 Mar;35(3):1416-1431
Phytotherapy research : PTR 2021 Mar;35(3):1416-1431
Inhibition of lipogenesis and induction of apoptosis by valproic acid in prostate cancer cells via the C/EBPα/SREBP-1 pathway.
Pang B, Zhang J, Zhang X, Yuan J, Shi Y, Qiao L
Acta biochimica et biophysica Sinica 2021 Mar 2;53(3):354-364
Acta biochimica et biophysica Sinica 2021 Mar 2;53(3):354-364
Gu-Ben-Fang-Xiao decoction modulates lipid metabolism by activating the AMPK pathway in asthma remission.
You YN, Xing QQ, Zhao X, Ji JJ, Yan H, Zhou T, Dong YM, Ren LS, Hou ST, Ding YY
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111403
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111403
BMP4-mediated browning of perivascular adipose tissue governs an anti-inflammatory program and prevents atherosclerosis.
Mu W, Qian S, Song Y, Yang L, Song S, Yang Q, Liu H, Liu Y, Pan D, Tang Y, Tang QQ
Redox biology 2021 Jul;43:101979
Redox biology 2021 Jul;43:101979
Comparison of multi-walled carbon nanotubes and halloysite nanotubes on lipid profiles in human umbilical vein endothelial cells.
Liu Y, Hu Q, Huang C, Cao Y
NanoImpact 2021 Jul;23:100333
NanoImpact 2021 Jul;23:100333
Disrupted glucose homeostasis and skeletal-muscle-specific glucose uptake in an exocyst knockout mouse model.
Fujimoto BA, Young M, Nakamura N, Ha H, Carter L, Pitts MW, Torres D, Noh HL, Suk S, Kim JK, Polgar N
The Journal of biological chemistry 2021 Jan-Jun;296:100482
The Journal of biological chemistry 2021 Jan-Jun;296:100482
Transcriptomic analysis suggested the involvement of impaired lipid droplet biogenesis in graphene oxide-induced cytotoxicity in human umbilical vein endothelial cells.
Luo Y, Wang X, Cao Y
Chemico-biological interactions 2021 Jan 5;333:109325
Chemico-biological interactions 2021 Jan 5;333:109325
Dexmedetomidine ameliorates high-fat diet-induced nonalcoholic fatty liver disease by targeting SCD1 in obesity mice.
Tao L, Guo X, Xu M, Wang Y, Xie W, Chen H, Ma M, Li X
Pharmacology research & perspectives 2021 Feb;9(1):e00700
Pharmacology research & perspectives 2021 Feb;9(1):e00700
A small molecule targeting ALOX12-ACC1 ameliorates nonalcoholic steatohepatitis in mice and macaques.
Zhang XJ, Ji YX, Cheng X, Cheng Y, Yang H, Wang J, Zhao LP, Huang YP, Sun D, Xiang H, Shen LJ, Li PL, Ma JP, Tian RF, Yang J, Yao X, Xu H, Liao R, Xiao L, Zhang P, Zhang X, Zhao GN, Wang X, Hu ML, Tian S, Wan J, Cai J, Ma X, Xu Q, Wang Y, Touyz RM, Liu PP, Loomba R, She ZG, Li H
Science translational medicine 2021 Dec 15;13(624):eabg8116
Science translational medicine 2021 Dec 15;13(624):eabg8116
TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis.
Huang D, Xu B, Liu L, Wu L, Zhu Y, Ghanbarpour A, Wang Y, Chen FJ, Lyu J, Hu Y, Kang Y, Zhou W, Wang X, Ding W, Li X, Jiang Z, Chen J, Zhang X, Zhou H, Li JZ, Guo C, Zheng W, Zhang X, Li P, Melia T, Reinisch K, Chen XW
Cell metabolism 2021 Aug 3;33(8):1655-1670.e8
Cell metabolism 2021 Aug 3;33(8):1655-1670.e8
Betaine prevented high-fat diet-induced NAFLD by regulating the FGF10/AMPK signaling pathway in ApoE(-/-) mice.
Chen W, Zhang X, Xu M, Jiang L, Zhou M, Liu W, Chen Z, Wang Y, Zou Q, Wang L
European journal of nutrition 2021 Apr;60(3):1655-1668
European journal of nutrition 2021 Apr;60(3):1655-1668
Four sesquiterpene glycosides from loquat (Eriobotrya japonica) leaf ameliorates palmitic acid-induced insulin resistance and lipid accumulation in HepG2 Cells via AMPK signaling pathway.
Li J, Ding X, Jian T, Lü H, Zhao L, Li J, Liu Y, Ren B, Chen J
PeerJ 2020;8:e10413
PeerJ 2020;8:e10413
Mogroside V Protects against Hepatic Steatosis in Mice on a High-Fat Diet and LO2 Cells Treated with Free Fatty Acids via AMPK Activation.
Li L, Zheng W, Wang C, Qi J, Li H
Evidence-based complementary and alternative medicine : eCAM 2020;2020:7826874
Evidence-based complementary and alternative medicine : eCAM 2020;2020:7826874
LncRNA DNAJC3-AS1 Regulates Fatty Acid Synthase via the EGFR Pathway to Promote the Progression of Colorectal Cancer.
Tang Y, Tang R, Tang M, Huang P, Liao Z, Zhou J, Zhou L, Su M, Chen P, Jiang J, Hu Y, Zhou Y, Liao Q, Zeng Z, Xiong W, Chen J, Nie S
Frontiers in oncology 2020;10:604534
Frontiers in oncology 2020;10:604534
L-Theanine affects intestinal mucosal immunity by regulating short-chain fatty acid metabolism under dietary fiber feeding.
Xu W, Lin L, Liu A, Zhang T, Zhang S, Li Y, Chen J, Gong Z, Liu Z, Xiao W
Food & function 2020 Sep 23;11(9):8369-8379
Food & function 2020 Sep 23;11(9):8369-8379
Disruption of Plin5 degradation by CMA causes lipid homeostasis imbalance in NAFLD.
Ma SY, Sun KS, Zhang M, Zhou X, Zheng XH, Tian SY, Liu YS, Chen L, Gao X, Ye J, Zhou XM, Wang JB, Han Y
Liver international : official journal of the International Association for the Study of the Liver 2020 Oct;40(10):2427-2438
Liver international : official journal of the International Association for the Study of the Liver 2020 Oct;40(10):2427-2438
Fatty acid synthase contributes to epithelial-mesenchymal transition and invasion of salivary adenoid cystic carcinoma through PRRX1/Wnt/β-catenin pathway.
Zhang WL, Wang SS, Jiang YP, Liu Y, Yu XH, Wu JB, Wang K, Pang X, Liao P, Liang XH, Tang YL
Journal of cellular and molecular medicine 2020 Oct;24(19):11465-11476
Journal of cellular and molecular medicine 2020 Oct;24(19):11465-11476
Effect and mechanism of ginsenoside Rg1-regulating hepatic steatosis in HepG2 cells induced by free fatty acid.
Gao Y, Zhang S, Li J, Zhao J, Xiao Q, Zhu Y, Zhang J, Huang W
Bioscience, biotechnology, and biochemistry 2020 Nov;84(11):2228-2240
Bioscience, biotechnology, and biochemistry 2020 Nov;84(11):2228-2240
Modulation of SIRT1-mediated signaling cascades in the liver contributes to the amelioration of nonalcoholic steatohepatitis in high fat fed middle-aged LDL receptor knockout mice by dihydromyricetin.
Zeng Y, Hua YQ, Wang W, Zhang H, Xu XL
Biochemical pharmacology 2020 May;175:113927
Biochemical pharmacology 2020 May;175:113927
Dlgap1 negatively regulates browning of white fat cells through effects on cell proliferation and apoptosis.
Zhang J, Yang J, Yang N, Ma J, Lu D, Dong Y, Liang H, Liu D, Cang M
Lipids in health and disease 2020 Mar 13;19(1):39
Lipids in health and disease 2020 Mar 13;19(1):39
The lncRNA Gm15622 stimulates SREBP-1c expression and hepatic lipid accumulation by sponging the miR-742-3p in mice.
Ma M, Duan R, Shen L, Liu M, Ji Y, Zhou H, Li C, Liang T, Li X, Guo L
Journal of lipid research 2020 Jul;61(7):1052-1064
Journal of lipid research 2020 Jul;61(7):1052-1064
Association between different levels of lipid metabolism‑related enzymes and fatty acid synthase in Wilms' tumor.
Wang X, Du G, Wu Y, Zhang Y, Guo F, Liu W, Wu R
International journal of oncology 2020 Feb;56(2):568-580
International journal of oncology 2020 Feb;56(2):568-580
Effects of di (2-ethylhexyl) phthalate and high-fat diet on lipid metabolism in rats by JAK2/STAT5.
Zhang Y, Zhou L, Zhang Z, Xu Q, Han X, Zhao Y, Song X, Zhao T, Ye L
Environmental science and pollution research international 2020 Feb;27(4):3837-3848
Environmental science and pollution research international 2020 Feb;27(4):3837-3848
Dihydroartemisinin inhibits endothelial cell tube formation by suppression of the STAT3 signaling pathway.
Gao P, Wang LL, Liu J, Dong F, Song W, Liao L, Wang B, Zhang W, Zhou X, Xie Q, Sun R, Liu J
Life sciences 2020 Feb 1;242:117221
Life sciences 2020 Feb 1;242:117221
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
Fu Y, Sun Y, Wang M, Hou Y, Huang W, Zhou D, Wang Z, Yang S, Tang W, Zhen J, Li Y, Wang X, Liu M, Zhang Y, Wang B, Liu G, Yu X, Sun J, Zhang C, Yi F
Cell metabolism 2020 Dec 1;32(6):1052-1062.e8
Cell metabolism 2020 Dec 1;32(6):1052-1062.e8
Responses of intestinal morphology and function in offspring to heat stress in primiparous sows during late gestation.
Guo H, He J, Yang X, Zheng W, Yao W
Journal of thermal biology 2020 Apr;89:102539
Journal of thermal biology 2020 Apr;89:102539
Identification of aberrantly methylated differentially expressed genes in prostate carcinoma using integrated bioinformatics.
Wu K, Yin X, Jin Y, Liu F, Gao J
Cancer cell international 2019;19:51
Cancer cell international 2019;19:51
Adenovirus-mediated expression of SIK1 improves hepatic glucose and lipid metabolism in type 2 diabetes mellitus rats.
Song D, Yin L, Wang C, Wen X
PloS one 2019;14(6):e0210930
PloS one 2019;14(6):e0210930
Downregulation of PDK4 Increases Lipogenesis and Associates with Poor Prognosis in Hepatocellular Carcinoma.
Yang C, Wang S, Ruan H, Li B, Cheng Z, He J, Zuo Q, Yu C, Wang H, Lv Y, Gu D, Jin G, Yao M, Qin W, Jin H
Journal of Cancer 2019;10(4):918-926
Journal of Cancer 2019;10(4):918-926
A Novel Regulatory Circuit "C/EBPα/miR-20a-5p/TOB2" Regulates Adipogenesis and Lipogenesis.
Zhou J, Yang J, Wang X, Li M, Li F, Zhu E, Li X, Li X, Wang B
Frontiers in endocrinology 2019;10:894
Frontiers in endocrinology 2019;10:894
Emodin Induced SREBP1-Dependent and SREBP1-Independent Apoptosis in Hepatocellular Carcinoma Cells.
Yang N, Li C, Li H, Liu M, Cai X, Cao F, Feng Y, Li M, Wang X
Frontiers in pharmacology 2019;10:709
Frontiers in pharmacology 2019;10:709
Sorafenib kills liver cancer cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids via the ATP-AMPK-mTOR-SREBP1 signaling pathway.
Liu G, Kuang S, Cao R, Wang J, Peng Q, Sun C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Sep;33(9):10089-10103
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Sep;33(9):10089-10103
Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1.
Zhang Y, Li C, Hu C, Wu Q, Cai Y, Xing S, Lu H, Wang L, Huang D, Sun L, Li T, He X, Zhong X, Wang J, Gao P, Smith ZJ, Jia W, Zhang H
EMBO reports 2019 Oct 4;20(10):e48115
EMBO reports 2019 Oct 4;20(10):e48115
The metabolic regulator small heterodimer partner contributes to the glucose and lipid homeostasis abnormalities induced by hepatitis C virus infection.
Chen J, Zhou Y, Zhuang Y, Qin T, Guo M, Jiang J, Niu J, Li JZ, Chen X, Wang Q
Metabolism: clinical and experimental 2019 Nov;100:153954
Metabolism: clinical and experimental 2019 Nov;100:153954
Hepatitis C virus nonstructural protein 5A perturbs lipid metabolism by modulating AMPK/SREBP-1c signaling.
Meng Z, Liu Q, Sun F, Qiao L
Lipids in health and disease 2019 Nov 4;18(1):191
Lipids in health and disease 2019 Nov 4;18(1):191
Mono-2-ethylhexyl phthalate (MEHP) promoted lipid accumulation via JAK2/STAT5 and aggravated oxidative stress in BRL-3A cells.
Zhang Y, Wang S, Zhao T, Yang L, Guo S, Shi Y, Zhang X, Zhou L, Ye L
Ecotoxicology and environmental safety 2019 Nov 30;184:109611
Ecotoxicology and environmental safety 2019 Nov 30;184:109611
Inhibition of fatty acid synthesis arrests colorectal neoplasm growth and metastasis: Anti-cancer therapeutical effects of natural cyclopeptide RA-XII.
Wang Y, Guo D, He J, Song L, Chen H, Zhang Z, Tan N
Biochemical and biophysical research communications 2019 May 14;512(4):819-824
Biochemical and biophysical research communications 2019 May 14;512(4):819-824
Di (2-ethylhexyl) phthalate Disorders Lipid Metabolism via TYK2/STAT1 and Autophagy in Rats.
Zhang YZ, Zhang ZM, Zhou LT, Zhu J, Zhang XH, Qi W, Ding S, Xu Q, Han X, Zhao YM, Song XY, Zhao TY, Ye L
Biomedical and environmental sciences : BES 2019 Jun;32(6):406-418
Biomedical and environmental sciences : BES 2019 Jun;32(6):406-418
Mono-2-ethylhexyl phthalate induces the expression of genes involved in fatty acid synthesis in HepG2 cells.
Bai J, He Z, Li Y, Jiang X, Yu H, Tan Q
Environmental toxicology and pharmacology 2019 Jul;69:104-111
Environmental toxicology and pharmacology 2019 Jul;69:104-111
Effect of selenium nanoparticles against abnormal fatty acid metabolism induced by hexavalent chromium in chicken's liver.
Luo M, Huang S, Zhang J, Zhang L, Mehmood K, Jiang J, Zhang N, Zhou D
Environmental science and pollution research international 2019 Jul;26(21):21828-21834
Environmental science and pollution research international 2019 Jul;26(21):21828-21834
Lingguizhugan decoction attenuates diet-induced obesity and hepatosteatosis via gut microbiota.
Liu MT, Huang YJ, Zhang TY, Tan LB, Lu XF, Qin J
World journal of gastroenterology 2019 Jul 21;25(27):3590-3606
World journal of gastroenterology 2019 Jul 21;25(27):3590-3606
Multi-walled carbon nanotubes promoted lipid accumulation in human aortic smooth muscle cells.
Yang H, Li J, Yang C, Liu H, Cao Y
Toxicology and applied pharmacology 2019 Jul 1;374:11-19
Toxicology and applied pharmacology 2019 Jul 1;374:11-19
Cancer‑associated adipocytes exhibit distinct phenotypes and facilitate tumor progression in pancreatic cancer.
Cai Z, Liang Y, Xing C, Wang H, Hu P, Li J, Huang H, Wang W, Jiang C
Oncology reports 2019 Dec;42(6):2537-2549
Oncology reports 2019 Dec;42(6):2537-2549
Porphyromonas gingivalis Promotes 4-Nitroquinoline-1-Oxide-Induced Oral Carcinogenesis With an Alteration of Fatty Acid Metabolism.
Wu JS, Zheng M, Zhang M, Pang X, Li L, Wang SS, Yang X, Wu JB, Tang YJ, Tang YL, Liang XH
Frontiers in microbiology 2018;9:2081
Frontiers in microbiology 2018;9:2081
Brg1 regulates pro-lipogenic transcription by modulating SREBP activity in hepatocytes.
Li N, Li M, Hong W, Shao J, Xu H, Shimano H, Lu J, Xu Y
Biochimica et biophysica acta. Molecular basis of disease 2018 Sep;1864(9 Pt B):2881-2889
Biochimica et biophysica acta. Molecular basis of disease 2018 Sep;1864(9 Pt B):2881-2889
RNA-binding proteins and heat-shock protein 90 are constituents of the cytoplasmic capping enzyme interactome.
Trotman JB, Agana BA, Giltmier AJ, Wysocki VH, Schoenberg DR
The Journal of biological chemistry 2018 Oct 26;293(43):16596-16607
The Journal of biological chemistry 2018 Oct 26;293(43):16596-16607
Inhibition of androgen receptor transactivation function by adenovirus type 12 E1A undermines prostate cancer cell survival.
Li D, Tian G, Wang J, Zhao LY, Co O, Underill ZC, Mymryk JS, Claessens F, Dehm SM, Daaka Y, Liao D
The Prostate 2018 Nov;78(15):1140-1156
The Prostate 2018 Nov;78(15):1140-1156
Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues.
Wallace M, Green CR, Roberts LS, Lee YM, McCarville JL, Sanchez-Gurmaches J, Meurs N, Gengatharan JM, Hover JD, Phillips SA, Ciaraldi TP, Guertin DA, Cabrales P, Ayres JS, Nomura DK, Loomba R, Metallo CM
Nature chemical biology 2018 Nov;14(11):1021-1031
Nature chemical biology 2018 Nov;14(11):1021-1031
Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice.
Chen S, Li X, Liu L, Liu C, Han X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Mar;32(3):1139-1153
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Mar;32(3):1139-1153
Effect of Dibutyltin Dilaurate on Triglyceride Metabolism through the Inhibition of the mTOR Pathway in Human HL7702 Liver Cells.
Qiao X, Li Y, Mai J, Ji X, Li Q
Molecules (Basel, Switzerland) 2018 Jul 6;23(7)
Molecules (Basel, Switzerland) 2018 Jul 6;23(7)
Adipose-specific lipin1 overexpression in mice protects against alcohol-induced liver injury.
Zhang W, Zhong W, Sun Q, Sun X, Zhou Z
Scientific reports 2018 Jan 11;8(1):408
Scientific reports 2018 Jan 11;8(1):408
Effects of calycosin against high-fat diet-induced nonalcoholic fatty liver disease in mice.
Duan X, Meng Q, Wang C, Liu Z, Sun H, Huo X, Sun P, Ma X, Peng J, Liu K
Journal of gastroenterology and hepatology 2018 Feb;33(2):533-542
Journal of gastroenterology and hepatology 2018 Feb;33(2):533-542
GLP-1/GLP-1R Signaling in Regulation of Adipocyte Differentiation and Lipogenesis.
Chen J, Zhao H, Ma X, Zhang Y, Lu S, Wang Y, Zong C, Qin D, Wang Y, Yingfeng Yang Y, Wang X, Liu Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;42(3):1165-1176
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;42(3):1165-1176
Lack of β, β-carotene-9', 10'-oxygenase 2 leads to hepatic mitochondrial dysfunction and cellular oxidative stress in mice.
Wu L, Guo X, Hartson SD, Davis MA, He H, Medeiros DM, Wang W, Clarke SL, Lucas EA, Smith BJ, von Lintig J, Lin D
Molecular nutrition & food research 2017 May;61(5)
Molecular nutrition & food research 2017 May;61(5)
Embelin attenuates adipogenesis and lipogenesis through activating canonical Wnt signaling and inhibits high-fat diet-induced obesity.
Gao Y, Li J, Xu X, Wang S, Yang Y, Zhou J, Zhang L, Zheng F, Li X, Wang B
International journal of obesity (2005) 2017 May;41(5):729-738
International journal of obesity (2005) 2017 May;41(5):729-738
Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission.
Wang L, Zhang T, Wang L, Cai Y, Zhong X, He X, Hu L, Tian S, Wu M, Hui L, Zhang H, Gao P
The EMBO journal 2017 May 15;36(10):1330-1347
The EMBO journal 2017 May 15;36(10):1330-1347
Mitochondrial toxicity of perfluorooctane sulfonate in mouse embryonic stem cell-derived cardiomyocytes.
Tang LL, Wang JD, Xu TT, Zhao Z, Zheng JJ, Ge RS, Zhu DY
Toxicology 2017 May 1;382:108-116
Toxicology 2017 May 1;382:108-116
Alisol B 23-acetate protects against non-alcoholic steatohepatitis in mice via farnesoid X receptor activation.
Meng Q, Duan XP, Wang CY, Liu ZH, Sun PY, Huo XK, Sun HJ, Peng JY, Liu KX
Acta pharmacologica Sinica 2017 Jan;38(1):69-79
Acta pharmacologica Sinica 2017 Jan;38(1):69-79
Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin.
Xue C, Wang C, Sun Y, Meng Q, Liu Z, Huo X, Sun P, Sun H, Ma X, Ma X, Peng J, Liu K
Oncotarget 2017 Jan 31;8(5):8622-8632
Oncotarget 2017 Jan 31;8(5):8622-8632
B7-H3 regulates lipid metabolism of lung cancer through SREBP1-mediated expression of FASN.
Luo D, Xiao H, Dong J, Li Y, Feng G, Cui M, Fan S
Biochemical and biophysical research communications 2017 Jan 22;482(4):1246-1251
Biochemical and biophysical research communications 2017 Jan 22;482(4):1246-1251
Calycosin attenuates triglyceride accumulation and hepatic fibrosis in murine model of non-alcoholic steatohepatitis via activating farnesoid X receptor.
Duan X, Meng Q, Wang C, Liu Z, Liu Q, Sun H, Sun P, Yang X, Huo X, Peng J, Liu K
Phytomedicine : international journal of phytotherapy and phytopharmacology 2017 Feb 15;25:83-92
Phytomedicine : international journal of phytotherapy and phytopharmacology 2017 Feb 15;25:83-92
Formaldehyde alters triglyceride synthesis and very low-density lipoprotein secretion in a time-dependent manner.
Bai J, Wang P, Liu Y, Zhang Y, Li Y, He Z, Hou L, Liang R
Environmental toxicology and pharmacology 2017 Dec;56:15-20
Environmental toxicology and pharmacology 2017 Dec;56:15-20
Impact of FHIT loss on the translation of cancer-associated mRNAs.
Kiss DL, Baez W, Huebner K, Bundschuh R, Schoenberg DR
Molecular cancer 2017 Dec 28;16(1):179
Molecular cancer 2017 Dec 28;16(1):179
Neurosecretory protein GL stimulates food intake, de novo lipogenesis, and onset of obesity.
Iwakoshi-Ukena E, Shikano K, Kondo K, Taniuchi S, Furumitsu M, Ochi Y, Sasaki T, Okamoto S, Bentley GE, Kriegsfeld LJ, Minokoshi Y, Ukena K
eLife 2017 Aug 11;6
eLife 2017 Aug 11;6
The Effect of Growth Hormone on Lipid Accumulation or Maturation in Adipocytes.
Zhang Y, Yu H, Gao P, Chen J, Yu C, Zong C, Lu S, Li X, Ma X, Liu Y, Wang X
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016;39(6):2135-2148
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016;39(6):2135-2148
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Molecular medicine reports 2016 Oct;14(4):3277-84
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Cancer medicine 2016 Jul;5(7):1599-606
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miR-22 inhibits tumor growth and metastasis by targeting ATP citrate lyase: evidence in osteosarcoma, prostate cancer, cervical cancer and lung cancer.
Xin M, Qiao Z, Li J, Liu J, Song S, Zhao X, Miao P, Tang T, Wang L, Liu W, Yang X, Dai K, Huang G
Oncotarget 2016 Jul 12;7(28):44252-44265
Oncotarget 2016 Jul 12;7(28):44252-44265
Gestational dietary betaine supplementation suppresses hepatic expression of lipogenic genes in neonatal piglets through epigenetic and glucocorticoid receptor-dependent mechanisms.
Cai D, Wang J, Jia Y, Liu H, Yuan M, Dong H, Zhao R
Biochimica et biophysica acta 2016 Jan;1861(1):41-50
Biochimica et biophysica acta 2016 Jan;1861(1):41-50
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Wang MD, Wu H, Fu GB, Zhang HL, Zhou X, Tang L, Dong LW, Qin CJ, Huang S, Zhao LH, Zeng M, Wu MC, Yan HX, Wang HY
Hepatology (Baltimore, Md.) 2016 Apr;63(4):1272-86
Hepatology (Baltimore, Md.) 2016 Apr;63(4):1272-86
TSH/TSHR Signaling Suppresses Fatty Acid Synthase (FASN) Expression in Adipocytes.
Chen J, Ren J, Jing Q, Lu S, Zhang Y, Liu Y, Yu C, Gao P, Zong C, Li X, Wang X
Journal of cellular physiology 2015 Sep;230(9):2233-9
Journal of cellular physiology 2015 Sep;230(9):2233-9
Long noncoding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR-9-mediated RXRA signaling pathway.
Cui M, Xiao Z, Wang Y, Zheng M, Song T, Cai X, Sun B, Ye L, Zhang X
Cancer research 2015 Mar 1;75(5):846-57
Cancer research 2015 Mar 1;75(5):846-57
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 10624-2-AP(FASN antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using FASN antibody 10624-2-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-FASN (IP:10624-2-AP, 4ug; Detection:10624-2-AP 1:500) with mouse liver tissue lysate 4000ug.
- Sample type
- tissue
