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- References [196]
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- Product number
- 10624-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10624-2-AP, RRID:AB_2100801
- Product name
- FASN antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated FASN antibody (Cat. #10624-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Traditional Chinese Medicine formula Dai-Zong-Fang alleviating hepatic steatosis in db/db mice via gut microbiota modulation.
SIRT2-mediated deacetylation of ACLY promotes the progression of oesophageal squamous cell carcinoma.
GSTM3 enhances radiosensitivity of nasopharyngeal carcinoma by promoting radiation-induced ferroptosis through USP14/FASN axis and GPX4.
Transcriptional and metabolic effects of aspartate-glutamate carrier isoform 1 (AGC1) downregulation in mouse oligodendrocyte precursor cells (OPCs).
Lipid droplet accumulation in Wdr45-deficient cells caused by impairment of chaperone-mediated autophagic degradation of Fasn.
Integrating transcriptomics and network pharmacology to reveal the mechanisms of total Rhizoma Coptidis alkaloids against nonalcoholic steatohepatitis.
Mechanistic of AMPK/ACC2 regulating myoblast differentiation by fatty acid oxidation of goat.
The effect and mechanism of combined exposure of MC-LR and NaNO(2) on liver lipid metabolism.
PITPNC1 Suppress CD8(+) T cell immune function and promote radioresistance in rectal cancer by modulating FASN/CD155.
Prepared Radix Polygoni Multiflori and emodin alleviate lipid droplet accumulation in nonalcoholic fatty liver disease through MAPK signaling pathway inhibition.
LncRNA Gm28382 promotes lipogenesis by interacting with miR-326-3p to regulate ChREBP signaling pathway in NAFLD.
TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis.
A nanoemulsion targeting adipose hypertrophy and hyperplasia shows anti-obesity efficiency in female mice.
Acetyl-CoA synthetase 2 promotes diabetic renal tubular injury in mice by rewiring fatty acid metabolism through SIRT1/ChREBP pathway.
Hypoxia induced cell dormancy of salivary adenoid cystic carcinoma through miR-922/DEC2 axis.
Farnesoid X receptor overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in nonalcoholic fatty liver disease.
Ginsenoside Rg5 inhibits lipid accumulation and hepatocyte apoptosis via the Notch1 signaling pathway in NASH mice.
Metastatic effects of perfluorooctanoic acid (PFOA) on Drosophila melanogaster with metabolic reprogramming and dysrhythmia in a multigenerational exposure scenario.
Topical rhubarb charcoal-crosslinked chitosan/silk fibroin sponge scaffold for the repair of diabetic ulcers improves hepatic lipid deposition in db/db mice via the AMPK signalling pathway.
SHMT2 reduces fatty liver but is necessary for liver inflammation and fibrosis in mice.
Hepatoprotective effect of dietary pterostilbene against high-fat-diet-induced lipid accumulation exacerbated by chronic jet lag via SIRT1 and SIRT3 activation.
Rutin ameliorated lipid metabolism dysfunction of diabetic NAFLD via AMPK/SREBP1 pathway.
Sodium butyrate alleviates free fatty acid-induced steatosis in primary chicken hepatocytes via the AMPK/PPARα pathway.
PPARγ alleviates preeclampsia development by regulating lipid metabolism and ferroptosis.
Herpetrione, a New Type of PPARα Ligand as a Therapeutic Strategy Against Nonalcoholic Steatohepatitis.
Differences in histomorphology and expression of key lipid regulated genes of four adipose tissues from Tibetan pigs.
Sphingomyelin synthase-related protein SMSr is a phosphatidylethanolamine phospholipase C that promotes nonalcoholic fatty liver disease.
miR-32-5p induces hepatic steatosis and hyperlipidemia by triggering de novo lipogenesis.
Metabolic characteristics of voriconazole - Induced liver injury in rats.
BCKDHA contributes to melanoma progression by promoting the expressions of lipogenic enzymes FASN and ACLY.
Long-term and liver-selected ginsenoside C-K nanoparticles retard NAFLD progression by restoring lipid homeostasis.
Cullin-associated and neddylation-dissociated 1 regulate reprogramming of lipid metabolism through SKP1-Cullin-1-F-box(FBXO11) -mediated heterogeneous nuclear ribonucleoprotein A2/B1 ubiquitination and promote hepatocellular carcinoma.
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
Sex differences in FASN protein concentrations in urinary exosomes related to serum triglycerides levels in healthy adults.
E3 ubiquitin ligase Siah1 aggravates NAFLD through Scp2 ubiquitination.
High dietary fructose promotes hepatocellular carcinoma progression by enhancing O-GlcNAcylation via microbiota-derived acetate.
A bacteria-derived tetramerized protein ameliorates nonalcoholic steatohepatitis in mice via binding and relocating acetyl-coA carboxylase.
Resensitizing Paclitaxel-Resistant Ovarian Cancer via Targeting Lipid Metabolism Key Enzymes CPT1A, SCD and FASN.
MiR-337-3p improves metabolic-associated fatty liver disease through regulation of glycolipid metabolism.
TRPV4 enhances the synthesis of fatty acids to drive the progression of ovarian cancer through the calcium-mTORC1/SREBP1 signaling pathway.
Inhibiting Phosphatidylcholine Remodeling in Adipose Tissue Increases Insulin Sensitivity.
Enhancement of PPARα-Inhibited Leucine Metabolism-Stimulated β-Casein Synthesis and Fatty Acid Synthesis in Primary Bovine Mammary Epithelial Cells.
TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN.
Dedifferentiated fat cells administration ameliorates abnormal expressions of fatty acids metabolism-related protein expressions and intestinal tissue damage in experimental necrotizing enterocolitis.
Insoluble Dietary Fiber from Soybean Residue (Okara) Exerts Anti-Obesity Effects by Promoting Hepatic Mitochondrial Fatty Acid Oxidation.
Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR-7/m-TOR/SREBP1 pathway on prostate cancer.
Developmental changes in lipid and fatty acid metabolism and the inhibition by in ovo feeding oleic acid in Muscovy duck embryogenesis.
Gamma-Muricholic Acid Inhibits Nonalcoholic Steatohepatitis: Abolishment of Steatosis-Dependent Peroxidative Impairment by FXR/SHP/LXRα/FASN Signaling.
Docosahexaenoic Acid Alters Lipid Metabolism Processes via H3K9ac Epigenetic Modification in Dairy Goat.
Long noncoding RNAs with peptide-encoding potential identified in esophageal squamous cell carcinoma: KDM4A-AS1-encoded peptide weakens cancer cell viability and migratory capacity.
Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1/2-PPARγ-Cd36 pathway.
Imbalance in ALR ubiquitination accelerates the progression of nonalcoholic steatohepatitis to hepatocellular carcinoma.
TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability.
Enhanced De Novo Lipid Synthesis Mediated by FASN Induces Chemoresistance in Colorectal Cancer.
LncRNA-TBP mediates TATA-binding protein recruitment to regulate myogenesis and induce slow-twitch myofibers.
CircRNA MBOAT2 promotes intrahepatic cholangiocarcinoma progression and lipid metabolism reprogramming by stabilizing PTBP1 to facilitate FASN mRNA cytoplasmic export.
Protein kinase C epsilon promotes de novo lipogenesis and tumor growth in prostate cancer cells by regulating the phosphorylation and nuclear translocation of pyruvate kinase isoform M2.
Knockout of ICAT in Adipose Tissue Alleviates Fibro-inflammation in Obese Mice.
Docosahexaenoic acid reverses PD-L1-mediated immune suppression by accelerating its ubiquitin-proteasome degradation.
L-Theanine regulates lipid metabolism by modulating gut microbiota and bile acid metabolism.
Vitamin D Receptor Activation Attenuates Olanzapine-Induced Dyslipidemia in Mice Through Alleviating Hepatic Endoplasmic Reticulum Stress.
Foxk1 stimulates adipogenic differentiation via a peroxisome proliferator-activated receptor gamma 2-dependent mechanism.
Expression profile of FASN gene and association of its polymorphisms with intramuscular fat content in Hu sheep.
F6P/G6P-mediated ChREBP activation promotes the insulin resistance-driven hepatic lipid deposition in zebrafish.
Lonicerae flos polysaccharides improve nonalcoholic fatty liver disease by activating the adenosine 5'-monophosphate-activated protein kinase pathway and reshaping gut microbiota.
Senescence-associated 13-HODE production promotes age-related liver steatosis by directly inhibiting catalase activity.
LncHLEF promotes hepatic lipid synthesis through miR-2188-3p/GATA6 axis and encoding peptides and enhances intramuscular fat deposition via exosome.
Therapeutic protein PAK restrains the progression of triple negative breast cancer through degrading SREBP-1 mRNA.
α-Lactalbumin Peptide Asp-Gln-Trp Ameliorates Hepatic Steatosis and Oxidative Stress in Free Fatty Acids-Treated HepG2 Cells and High-Fat Diet-Induced NAFLD Mice by Activating the PPARα Pathway.
Decreased Imiquimod-Induced Psoriasis-Like Skin Inflammation in a Novel Mvd(F250S/+) Knock-In Mouse Model.
Integrated multi-omics analyses reveal Jorunnamycin A as a novel suppressor for muscle-invasive bladder cancer by targeting FASN and TOP1.
Cordycepin reprogramming lipid metabolism to block metastasis and EMT via ERO1A/mTOR/SREBP1 axis in cholangiocarcinoma.
Epiberberine regulates lipid synthesis through SHP (NR0B2) to improve non-alcoholic steatohepatitis.
Protopanaxadiol ameliorates NAFLD by regulating hepatocyte lipid metabolism through AMPK/SIRT1 signaling pathway.
Tandem mass tag-based quantitative proteomics analysis reveals the effects of the α-lactalbumin peptides GINY and DQW on lipid deposition and oxidative stress in HepG2 cells.
A UPLC-Q-TOF/MS and network pharmacology method to explore the mechanism of Anhua fuzhuan tea intervention in nonalcoholic fatty liver disease.
DAXX drives de novo lipogenesis and contributes to tumorigenesis.
MiR-328-5p inhibits the adipogenic differentiation of hMSCs by targeting fatty acid synthase.
Profile analysis and functional modeling identify circular RNAs in nonalcoholic fatty liver disease as regulators of hepatic lipid metabolism.
D-Mannose Regulates Hepatocyte Lipid Metabolism via PI3K/Akt/mTOR Signaling Pathway and Ameliorates Hepatic Steatosis in Alcoholic Liver Disease.
Effects of Poria cocos extract on metabolic dysfunction-associated fatty liver disease via the FXR/PPARα-SREBPs pathway.
PRMT5 confers lipid metabolism reprogramming, tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours.
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.
A therapeutic DC vaccine with maintained immunological activity exhibits robust anti-tumor efficacy.
Metabolic Syndrome Ameliorated by 4-Methylesculetin by Reducing Hepatic Lipid Accumulation.
Super-enhancer-associated INSM2 regulates lipid metabolism by modulating mTOR signaling pathway in neuroblastoma.
The role of hepatic Surf4 in lipoprotein metabolism and the development of atherosclerosis in apoE(-/-) mice.
Cerulenin suppresses ErbB2-overexpressing breast cancer by targeting ErbB2/PKM2 pathway.
Derepression of the USP22-FASN axis by p53 loss under oxidative stress drives lipogenesis and tumorigenesis.
circPRKAA1 activates a Ku80/Ku70/SREBP-1 axis driving de novo fatty acid synthesis in cancer cells.
Obesity promotes lipid accumulation in lymph node metastasis of gastric cancer: a retrospective case‒control study.
FASN promotes lymph node metastasis in cervical cancer via cholesterol reprogramming and lymphangiogenesis.
Dietary L-arginine supplementation of tilapia (Oreochromis niloticus) alters the microbial population and activates intestinal fatty acid oxidation.
Effects of maternal feed intake restriction on the blood parameters, fatty acid profile and lipogenetic genes expression of perirenal fat in offspring kids.
Psoralen Suppresses Lipid Deposition by Alleviating Insulin Resistance and Promoting Autophagy in Oleate-Induced L02 Cells.
Novel phosphanegold(I) thiolate complexes suppress de novo lipid synthesis in human lung cancer.
CRISPR/Cas9-Induced Knockout of miR-24 Reduces Cholesterol and Monounsaturated Fatty Acid Content in Primary Goat Mammary Epithelial Cells.
Quantitative proteomic analysis of Bi Zhong Xiao decoction against collagen-induced arthritis rats in the early and late stages.
Scutellarin ameliorates hepatic lipid accumulation by enhancing autophagy and suppressing IRE1α/XBP1 pathway.
MicroRNA-377-3p inhibits hepatocellular carcinoma growth and metastasis through negative regulation of CPT1C-mediated fatty acid oxidation.
Ginsenoside CK ameliorates hepatic lipid accumulation via activating the LKB1/AMPK pathway in vitro and in vivo.
Protein C receptor maintains cancer stem cell properties via activating lipid synthesis in nasopharyngeal carcinoma.
TiO(2) nanosheets promote the transformation of vascular smooth muscle cells into foam cells in vitro and in vivo through the up-regulation of nuclear factor kappa B subunit 2.
Polyphyllin I improves myocardial damage in coronary artery disease via modulating lipid metabolism and myocardial apoptosis.
Di-2-ethylhexyl phthalate-induced miR-155-5p promoted lipid metabolism via inhibiting cAMP/PKA signaling pathway in human trophoblastic HTR-8/Svneo cells.
Loss of Mature Lamin A/C Triggers a Shift in Intracellular Metabolic Homeostasis via AMPKα Activation.
Microalgae oil from Schizochytrium sp. alleviates obesity and modulates gut microbiota in high-fat diet-fed mice.
Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion.
MiR-103-3p promotes hepatic steatosis to aggravate nonalcoholic fatty liver disease by targeting of ACOX1.
Salvia-Nelumbinis naturalis improves lipid metabolism of NAFLD by regulating the SIRT1/AMPK signaling pathway.
Functionalized gadofullerene ameliorates impaired glycolipid metabolism in type 2 diabetic mice.
Long noncoding RNA ZFP36L2-AS functions as a metabolic modulator to regulate muscle development.
RNF8 up-regulates AR/ARV7 action to contribute to advanced prostate cancer progression.
LYAR Promotes Colorectal Cancer Progression by Upregulating FSCN1 Expression and Fatty Acid Metabolism.
The Mutual Inhibition of FoxO1 and SREBP-1c Regulated the Progression of Hepatoblastoma by Regulating Fatty Acid Metabolism.
PRPF6 promotes androgen receptor/androgen receptor-variant 7 actions in castration-resistant prostate cancer cells.
SOAT1 Promotes Gastric Cancer Lymph Node Metastasis Through Lipid Synthesis.
High-Salt Attenuates the Efficacy of Dapagliflozin in Tubular Protection by Impairing Fatty Acid Metabolism in Diabetic Kidney Disease.
Pterostilbene attenuates RIPK3-dependent hepatocyte necroptosis in alcoholic liver disease via SIRT2-mediated NFATc4 deacetylation.
Deficiency of intestinal Bmal1 prevents obesity induced by high-fat feeding.
Novel SREBP1 inhibitor cinobufotalin suppresses proliferation of hepatocellular carcinoma by targeting lipogenesis.
Comprehensive multi-omics approaches reveal the hepatotoxic mechanism of perfluorohexanoic acid (PFHxA) in mice.
Exercise improves lipid metabolism disorders induced by high-fat diet in a SESN2/JNK-independent manner.
Changes of lipid profiles in human umbilical vein endothelial cells exposed to zirconia nanoparticles with or without the presence of free fatty acids.
Lipid metabolism regulator human hydroxysteroid dehydrogenase-like 2 (HSDL2) modulates cervical cancer cell proliferation and metastasis.
Apple polyphenol extract alleviates lipid accumulation in free-fatty-acid-exposed HepG2 cells via activating autophagy mediated by SIRT1/AMPK signaling.
Inhibition of lipogenesis and induction of apoptosis by valproic acid in prostate cancer cells via the C/EBPα/SREBP-1 pathway.
Gu-Ben-Fang-Xiao decoction modulates lipid metabolism by activating the AMPK pathway in asthma remission.
BMP4-mediated browning of perivascular adipose tissue governs an anti-inflammatory program and prevents atherosclerosis.
Comparison of multi-walled carbon nanotubes and halloysite nanotubes on lipid profiles in human umbilical vein endothelial cells.
Disrupted glucose homeostasis and skeletal-muscle-specific glucose uptake in an exocyst knockout mouse model.
Transcriptomic analysis suggested the involvement of impaired lipid droplet biogenesis in graphene oxide-induced cytotoxicity in human umbilical vein endothelial cells.
Dexmedetomidine ameliorates high-fat diet-induced nonalcoholic fatty liver disease by targeting SCD1 in obesity mice.
A small molecule targeting ALOX12-ACC1 ameliorates nonalcoholic steatohepatitis in mice and macaques.
TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis.
Betaine prevented high-fat diet-induced NAFLD by regulating the FGF10/AMPK signaling pathway in ApoE(-/-) mice.
Four sesquiterpene glycosides from loquat (Eriobotrya japonica) leaf ameliorates palmitic acid-induced insulin resistance and lipid accumulation in HepG2 Cells via AMPK signaling pathway.
Mogroside V Protects against Hepatic Steatosis in Mice on a High-Fat Diet and LO2 Cells Treated with Free Fatty Acids via AMPK Activation.
LncRNA DNAJC3-AS1 Regulates Fatty Acid Synthase via the EGFR Pathway to Promote the Progression of Colorectal Cancer.
L-Theanine affects intestinal mucosal immunity by regulating short-chain fatty acid metabolism under dietary fiber feeding.
Disruption of Plin5 degradation by CMA causes lipid homeostasis imbalance in NAFLD.
Fatty acid synthase contributes to epithelial-mesenchymal transition and invasion of salivary adenoid cystic carcinoma through PRRX1/Wnt/β-catenin pathway.
Effect and mechanism of ginsenoside Rg1-regulating hepatic steatosis in HepG2 cells induced by free fatty acid.
Modulation of SIRT1-mediated signaling cascades in the liver contributes to the amelioration of nonalcoholic steatohepatitis in high fat fed middle-aged LDL receptor knockout mice by dihydromyricetin.
Dlgap1 negatively regulates browning of white fat cells through effects on cell proliferation and apoptosis.
The lncRNA Gm15622 stimulates SREBP-1c expression and hepatic lipid accumulation by sponging the miR-742-3p in mice.
Association between different levels of lipid metabolism‑related enzymes and fatty acid synthase in Wilms' tumor.
Effects of di (2-ethylhexyl) phthalate and high-fat diet on lipid metabolism in rats by JAK2/STAT5.
Dihydroartemisinin inhibits endothelial cell tube formation by suppression of the STAT3 signaling pathway.
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
Responses of intestinal morphology and function in offspring to heat stress in primiparous sows during late gestation.
Identification of aberrantly methylated differentially expressed genes in prostate carcinoma using integrated bioinformatics.
Downregulation of PDK4 Increases Lipogenesis and Associates with Poor Prognosis in Hepatocellular Carcinoma.
A Novel Regulatory Circuit "C/EBPα/miR-20a-5p/TOB2" Regulates Adipogenesis and Lipogenesis.
Emodin Induced SREBP1-Dependent and SREBP1-Independent Apoptosis in Hepatocellular Carcinoma Cells.
Sorafenib kills liver cancer cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids via the ATP-AMPK-mTOR-SREBP1 signaling pathway.
Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1.
The metabolic regulator small heterodimer partner contributes to the glucose and lipid homeostasis abnormalities induced by hepatitis C virus infection.
Hepatitis C virus nonstructural protein 5A perturbs lipid metabolism by modulating AMPK/SREBP-1c signaling.
Mono-2-ethylhexyl phthalate (MEHP) promoted lipid accumulation via JAK2/STAT5 and aggravated oxidative stress in BRL-3A cells.
Inhibition of fatty acid synthesis arrests colorectal neoplasm growth and metastasis: Anti-cancer therapeutical effects of natural cyclopeptide RA-XII.
Di (2-ethylhexyl) phthalate Disorders Lipid Metabolism via TYK2/STAT1 and Autophagy in Rats.
Mono-2-ethylhexyl phthalate induces the expression of genes involved in fatty acid synthesis in HepG2 cells.
Effect of selenium nanoparticles against abnormal fatty acid metabolism induced by hexavalent chromium in chicken's liver.
Lingguizhugan decoction attenuates diet-induced obesity and hepatosteatosis via gut microbiota.
Multi-walled carbon nanotubes promoted lipid accumulation in human aortic smooth muscle cells.
Cancer‑associated adipocytes exhibit distinct phenotypes and facilitate tumor progression in pancreatic cancer.
Porphyromonas gingivalis Promotes 4-Nitroquinoline-1-Oxide-Induced Oral Carcinogenesis With an Alteration of Fatty Acid Metabolism.
Brg1 regulates pro-lipogenic transcription by modulating SREBP activity in hepatocytes.
RNA-binding proteins and heat-shock protein 90 are constituents of the cytoplasmic capping enzyme interactome.
Inhibition of androgen receptor transactivation function by adenovirus type 12 E1A undermines prostate cancer cell survival.
Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues.
Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice.
Effect of Dibutyltin Dilaurate on Triglyceride Metabolism through the Inhibition of the mTOR Pathway in Human HL7702 Liver Cells.
Adipose-specific lipin1 overexpression in mice protects against alcohol-induced liver injury.
Effects of calycosin against high-fat diet-induced nonalcoholic fatty liver disease in mice.
GLP-1/GLP-1R Signaling in Regulation of Adipocyte Differentiation and Lipogenesis.
Lack of β, β-carotene-9', 10'-oxygenase 2 leads to hepatic mitochondrial dysfunction and cellular oxidative stress in mice.
Embelin attenuates adipogenesis and lipogenesis through activating canonical Wnt signaling and inhibits high-fat diet-induced obesity.
Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission.
Mitochondrial toxicity of perfluorooctane sulfonate in mouse embryonic stem cell-derived cardiomyocytes.
Alisol B 23-acetate protects against non-alcoholic steatohepatitis in mice via farnesoid X receptor activation.
Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin.
B7-H3 regulates lipid metabolism of lung cancer through SREBP1-mediated expression of FASN.
Calycosin attenuates triglyceride accumulation and hepatic fibrosis in murine model of non-alcoholic steatohepatitis via activating farnesoid X receptor.
Formaldehyde alters triglyceride synthesis and very low-density lipoprotein secretion in a time-dependent manner.
Impact of FHIT loss on the translation of cancer-associated mRNAs.
Neurosecretory protein GL stimulates food intake, de novo lipogenesis, and onset of obesity.
The Effect of Growth Hormone on Lipid Accumulation or Maturation in Adipocytes.
Jatrorrhizine hydrochloride attenuates hyperlipidemia in a high-fat diet-induced obesity mouse model.
Fatty acid synthase regulates invasion and metastasis of colorectal cancer via Wnt signaling pathway.
miR-22 inhibits tumor growth and metastasis by targeting ATP citrate lyase: evidence in osteosarcoma, prostate cancer, cervical cancer and lung cancer.
Gestational dietary betaine supplementation suppresses hepatic expression of lipogenic genes in neonatal piglets through epigenetic and glucocorticoid receptor-dependent mechanisms.
Acetyl-coenzyme A carboxylase alpha promotion of glucose-mediated fatty acid synthesis enhances survival of hepatocellular carcinoma in mice and patients.
TSH/TSHR Signaling Suppresses Fatty Acid Synthase (FASN) Expression in Adipocytes.
Long noncoding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR-9-mediated RXRA signaling pathway.
Zhang LW, Zhu LL, Zhu XY, Fu SQ, Liu XM
Frontiers in pharmacology 2024;15:1337057
Frontiers in pharmacology 2024;15:1337057
SIRT2-mediated deacetylation of ACLY promotes the progression of oesophageal squamous cell carcinoma.
Zhang X, Xu Y, Li S, Qin Y, Zhu G, Zhang Q, Zhang Y, Guan F, Fan T, Liu H
Journal of cellular and molecular medicine 2024 Mar;28(6):e18129
Journal of cellular and molecular medicine 2024 Mar;28(6):e18129
GSTM3 enhances radiosensitivity of nasopharyngeal carcinoma by promoting radiation-induced ferroptosis through USP14/FASN axis and GPX4.
Chen Y, Feng Y, Lin Y, Zhou X, Wang L, Zhou Y, Lin K, Cai L
British journal of cancer 2024 Mar;130(5):755-768
British journal of cancer 2024 Mar;130(5):755-768
Transcriptional and metabolic effects of aspartate-glutamate carrier isoform 1 (AGC1) downregulation in mouse oligodendrocyte precursor cells (OPCs).
Balboni N, Babini G, Poeta E, Protti M, Mercolini L, Magnifico MC, Barile SN, Massenzio F, Pignataro A, Giorgi FM, Lasorsa FM, Monti B
Cellular & molecular biology letters 2024 Mar 29;29(1):44
Cellular & molecular biology letters 2024 Mar 29;29(1):44
Lipid droplet accumulation in Wdr45-deficient cells caused by impairment of chaperone-mediated autophagic degradation of Fasn.
Xiong Q, Sun H, Wang Y, Xu Q, Zhang Y, Xu M, Zhao Z, Li P, Wu C
Lipids in health and disease 2024 Mar 28;23(1):91
Lipids in health and disease 2024 Mar 28;23(1):91
Integrating transcriptomics and network pharmacology to reveal the mechanisms of total Rhizoma Coptidis alkaloids against nonalcoholic steatohepatitis.
Li J, Ma Z, Yang Z, Yang M, Li C, Li M, Li X, Chen X, Ma H, Chen W, Ye X, Li X
Journal of ethnopharmacology 2024 Mar 25;322:117600
Journal of ethnopharmacology 2024 Mar 25;322:117600
Mechanistic of AMPK/ACC2 regulating myoblast differentiation by fatty acid oxidation of goat.
Kang Z, Zhang Z, Li J, Deng K, Wang F, Fan Y
International journal of biological macromolecules 2024 Jun;270(Pt 2):132243
International journal of biological macromolecules 2024 Jun;270(Pt 2):132243
The effect and mechanism of combined exposure of MC-LR and NaNO(2) on liver lipid metabolism.
Yang J, Zhang Z, Du X, Wang Y, Meng R, Ge K, Wu C, Liang X, Zhang H, Guo H
Environmental research 2024 Jul 1;252(Pt 4):119113
Environmental research 2024 Jul 1;252(Pt 4):119113
PITPNC1 Suppress CD8(+) T cell immune function and promote radioresistance in rectal cancer by modulating FASN/CD155.
Liang J, Liao L, Xie L, Tang W, Yu X, Lu Y, Chen H, Xu J, Sun L, Wu H, Cui C, Tan Y
Journal of translational medicine 2024 Jan 30;22(1):117
Journal of translational medicine 2024 Jan 30;22(1):117
Prepared Radix Polygoni Multiflori and emodin alleviate lipid droplet accumulation in nonalcoholic fatty liver disease through MAPK signaling pathway inhibition.
Huang C, Zhang Y, Xu Y, Wei S, Yang T, Wang S, Li C, Lin H, Li X, Zhao S, Zhu L, Pan W
Aging 2024 Jan 26;16(3):2362-2384
Aging 2024 Jan 26;16(3):2362-2384
LncRNA Gm28382 promotes lipogenesis by interacting with miR-326-3p to regulate ChREBP signaling pathway in NAFLD.
Yang S, Zhang Y, Zhang Y, Yin L, Han X, Zhao X, Wang N, Xu L
International immunopharmacology 2024 Jan 25;127:111444
International immunopharmacology 2024 Jan 25;127:111444
TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis.
Hao XL, Lv YF, Li DF, Bai FH, Gong J, Pan GQ, Su LX, Wang YL, Fu WL, Liu B, Huang L, Yan D, Tan QL, Liu JY, Guo QN
Journal of translational medicine 2024 Jan 2;22(1):6
Journal of translational medicine 2024 Jan 2;22(1):6
A nanoemulsion targeting adipose hypertrophy and hyperplasia shows anti-obesity efficiency in female mice.
Lu Y, Luo Z, Zhou H, Shi Y, Zhu Y, Guo X, Huang J, Zhang J, Liu X, Wang S, Shan X, Yin H, Du Y, Li Q, You J, Luo L
Nature communications 2024 Jan 2;15(1):72
Nature communications 2024 Jan 2;15(1):72
Acetyl-CoA synthetase 2 promotes diabetic renal tubular injury in mice by rewiring fatty acid metabolism through SIRT1/ChREBP pathway.
Lu J, Li XQ, Chen PP, Zhang JX, Li L, Wang GH, Liu XQ, Jiang CM, Ma KL
Acta pharmacologica Sinica 2024 Feb;45(2):366-377
Acta pharmacologica Sinica 2024 Feb;45(2):366-377
Hypoxia induced cell dormancy of salivary adenoid cystic carcinoma through miR-922/DEC2 axis.
Dai L, Xian H, Wang H, Li M, Zhang M, Liang XH, Tang YL
Translational oncology 2024 Feb;40:101868
Translational oncology 2024 Feb;40:101868
Farnesoid X receptor overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in nonalcoholic fatty liver disease.
Xu S, Kong L, Li L, Wang C, Gu J, Luo H, Meng Q
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166930
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166930
Ginsenoside Rg5 inhibits lipid accumulation and hepatocyte apoptosis via the Notch1 signaling pathway in NASH mice.
Li N, Zhu C, Fu R, Ma X, Duan Z, Fan D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155287
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155287
Metastatic effects of perfluorooctanoic acid (PFOA) on Drosophila melanogaster with metabolic reprogramming and dysrhythmia in a multigenerational exposure scenario.
Fangninou FF, Yu Z, Li W, Xue L, Yin D
The Science of the total environment 2024 Feb 20;912:169305
The Science of the total environment 2024 Feb 20;912:169305
Topical rhubarb charcoal-crosslinked chitosan/silk fibroin sponge scaffold for the repair of diabetic ulcers improves hepatic lipid deposition in db/db mice via the AMPK signalling pathway.
Tan Q, He Q, Peng Z, Zeng X, Liu Y, Li D, Wang S, Wang J
Lipids in health and disease 2024 Feb 20;23(1):52
Lipids in health and disease 2024 Feb 20;23(1):52
SHMT2 reduces fatty liver but is necessary for liver inflammation and fibrosis in mice.
Chen G, Zhou G, Zhai L, Bao X, Tiwari N, Li J, Mottillo E, Wang J
Communications biology 2024 Feb 12;7(1):173
Communications biology 2024 Feb 12;7(1):173
Hepatoprotective effect of dietary pterostilbene against high-fat-diet-induced lipid accumulation exacerbated by chronic jet lag via SIRT1 and SIRT3 activation.
Koh YC, Yao CH, Lee PS, Nagabhushanam K, Ho CT, Pan MH
Phytotherapy research : PTR 2024 Aug;38(8):4099-4113
Phytotherapy research : PTR 2024 Aug;38(8):4099-4113
Rutin ameliorated lipid metabolism dysfunction of diabetic NAFLD via AMPK/SREBP1 pathway.
Liu Y, Sun Z, Dong R, Liu P, Zhang X, Li Y, Lai X, Cheong HF, Wu Y, Wang Y, Zhou H, Gui D, Xu Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155437
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155437
Sodium butyrate alleviates free fatty acid-induced steatosis in primary chicken hepatocytes via the AMPK/PPARα pathway.
Ding J, Liu J, Chen J, Cheng X, Cao H, Guo X, Hu G, Zhuang Y
Poultry science 2024 Apr;103(4):103482
Poultry science 2024 Apr;103(4):103482
PPARγ alleviates preeclampsia development by regulating lipid metabolism and ferroptosis.
Lai W, Yu L, Deng Y
Communications biology 2024 Apr 9;7(1):429
Communications biology 2024 Apr 9;7(1):429
Herpetrione, a New Type of PPARα Ligand as a Therapeutic Strategy Against Nonalcoholic Steatohepatitis.
Linghu L, Zong W, Liao Y, Chen Q, Meng F, Wang G, Liao Z, Lan X, Chen M
Research (Washington, D.C.) 2023;6:0276
Research (Washington, D.C.) 2023;6:0276
Differences in histomorphology and expression of key lipid regulated genes of four adipose tissues from Tibetan pigs.
Lin C, Dong Z, Song J, Wang S, Yang Y, Li H, Feng Z, Pei Y
PeerJ 2023;11:e14556
PeerJ 2023;11:e14556
Sphingomyelin synthase-related protein SMSr is a phosphatidylethanolamine phospholipase C that promotes nonalcoholic fatty liver disease.
Chiang YP, Li Z, He M, Jones Q, Pan M, Han X, Jiang XC
The Journal of biological chemistry 2023 Sep;299(9):105162
The Journal of biological chemistry 2023 Sep;299(9):105162
miR-32-5p induces hepatic steatosis and hyperlipidemia by triggering de novo lipogenesis.
Wang YD, Wu LL, Mai YN, Wang K, Tang Y, Wang QY, Li JY, Jiang LY, Liao ZZ, Hu C, Wang YY, Liu JJ, Liu JH, Xiao XH
Metabolism: clinical and experimental 2023 Sep;146:155660
Metabolism: clinical and experimental 2023 Sep;146:155660
Metabolic characteristics of voriconazole - Induced liver injury in rats.
Du Q, Teng M, Yang L, Meng C, Qiu Y, Wang C, Chen J, Wang T, Chen S, Luo Y, Sun J, Dong Y
Chemico-biological interactions 2023 Sep 25;383:110693
Chemico-biological interactions 2023 Sep 25;383:110693
BCKDHA contributes to melanoma progression by promoting the expressions of lipogenic enzymes FASN and ACLY.
Tian Y, Ma J, Wang M, Yi X, Guo S, Wang H, Zhang H, Wang H, Yang Y, Zhang B, Du J, Shi Q, Gao T, Li C, Guo W
Experimental dermatology 2023 Oct;32(10):1633-1643
Experimental dermatology 2023 Oct;32(10):1633-1643
Long-term and liver-selected ginsenoside C-K nanoparticles retard NAFLD progression by restoring lipid homeostasis.
Yue C, Li D, Fan S, Tao F, Yu Y, Lu W, Chen Q, Yuan A, Wu J, Zhao G, Dong H, Hu Y
Biomaterials 2023 Oct;301:122291
Biomaterials 2023 Oct;301:122291
Cullin-associated and neddylation-dissociated 1 regulate reprogramming of lipid metabolism through SKP1-Cullin-1-F-box(FBXO11) -mediated heterogeneous nuclear ribonucleoprotein A2/B1 ubiquitination and promote hepatocellular carcinoma.
Zhang H, Xia P, Yang Z, Liu J, Zhu Y, Huang Z, Zhang Z, Yuan Y
Clinical and translational medicine 2023 Oct;13(10):e1443
Clinical and translational medicine 2023 Oct;13(10):e1443
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
Song K, Sun H, Tu B, Zhou Y, Lin LC, Liu ZY, Li R, Yang JJ, Zhang Y, Zhao JY, Tao H
iScience 2023 Oct 20;26(10):107931
iScience 2023 Oct 20;26(10):107931
Sex differences in FASN protein concentrations in urinary exosomes related to serum triglycerides levels in healthy adults.
Li T, Meng W, Liu TC, Wang YZ, Zhang M
Lipids in health and disease 2023 Oct 19;22(1):176
Lipids in health and disease 2023 Oct 19;22(1):176
E3 ubiquitin ligase Siah1 aggravates NAFLD through Scp2 ubiquitination.
Zhu Z, Hu X, Liu K, Li J, Fan K, Wang H, Wang L, He L, Ma Y, Guan R, Wang Z
International immunopharmacology 2023 Nov;124(Pt A):110897
International immunopharmacology 2023 Nov;124(Pt A):110897
High dietary fructose promotes hepatocellular carcinoma progression by enhancing O-GlcNAcylation via microbiota-derived acetate.
Zhou P, Chang WY, Gong DA, Xia J, Chen W, Huang LY, Liu R, Liu Y, Chen C, Wang K, Tang N, Huang AL
Cell metabolism 2023 Nov 7;35(11):1961-1975.e6
Cell metabolism 2023 Nov 7;35(11):1961-1975.e6
A bacteria-derived tetramerized protein ameliorates nonalcoholic steatohepatitis in mice via binding and relocating acetyl-coA carboxylase.
Lin Y, Yang M, Huang L, Yang F, Fan J, Qiang Y, Chang Y, Zhou W, Yan L, Xiong J, Ping J, Chen S, Men D, Li F
Cell reports 2023 Nov 28;42(11):113453
Cell reports 2023 Nov 28;42(11):113453
Resensitizing Paclitaxel-Resistant Ovarian Cancer via Targeting Lipid Metabolism Key Enzymes CPT1A, SCD and FASN.
Ma Q, Liu Z, Wang T, Zhao P, Liu M, Wang Y, Zhao W, Yuan Y, Li S
International journal of molecular sciences 2023 Nov 19;24(22)
International journal of molecular sciences 2023 Nov 19;24(22)
MiR-337-3p improves metabolic-associated fatty liver disease through regulation of glycolipid metabolism.
Xu X, Yu C, He H, Pan X, Hou A, Feng J, Tan R, Gong L, Chen J, Ren J
iScience 2023 Nov 17;26(11):108352
iScience 2023 Nov 17;26(11):108352
TRPV4 enhances the synthesis of fatty acids to drive the progression of ovarian cancer through the calcium-mTORC1/SREBP1 signaling pathway.
Lin L, Li X, Wu AJ, Xiu JB, Gan YZ, Yang XM, Ai ZH
iScience 2023 Nov 17;26(11):108226
iScience 2023 Nov 17;26(11):108226
Inhibiting Phosphatidylcholine Remodeling in Adipose Tissue Increases Insulin Sensitivity.
He M, Li Z, Tung VSK, Pan M, Han X, Evgrafov O, Jiang XC
Diabetes 2023 Nov 1;72(11):1547-1559
Diabetes 2023 Nov 1;72(11):1547-1559
Enhancement of PPARα-Inhibited Leucine Metabolism-Stimulated β-Casein Synthesis and Fatty Acid Synthesis in Primary Bovine Mammary Epithelial Cells.
Huang J, Li J, Ning Y, Ren Y, Shao Y, Zhang H, Zong X, Shi H
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16184-16193
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16184-16193
TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN.
Zhang K, Yang C, Zhou X, Liang J, Guo J, Li M, Zhang Y, Shao S, Sun P, Li K, Huang J, Chen F, Liang X, Su D
Cellular and molecular life sciences : CMLS 2023 May 30;80(6):168
Cellular and molecular life sciences : CMLS 2023 May 30;80(6):168
Dedifferentiated fat cells administration ameliorates abnormal expressions of fatty acids metabolism-related protein expressions and intestinal tissue damage in experimental necrotizing enterocolitis.
Mimatsu H, Onoda A, Kazama T, Nishijima K, Shimoyama Y, Go S, Ueda K, Takahashi Y, Matsumoto T, Hayakawa M, Sato Y
Scientific reports 2023 May 22;13(1):8266
Scientific reports 2023 May 22;13(1):8266
Insoluble Dietary Fiber from Soybean Residue (Okara) Exerts Anti-Obesity Effects by Promoting Hepatic Mitochondrial Fatty Acid Oxidation.
Zhang J, Wang S, Wang J, Liu W, Gong H, Zhang Z, Lyu B, Yu H
Foods (Basel, Switzerland) 2023 May 22;12(10)
Foods (Basel, Switzerland) 2023 May 22;12(10)
Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR-7/m-TOR/SREBP1 pathway on prostate cancer.
Xu W, Ding J, Li B, Sun T, You X, He Q, Sheng W
BioFactors (Oxford, England) 2023 Mar;49(2):438-456
BioFactors (Oxford, England) 2023 Mar;49(2):438-456
Developmental changes in lipid and fatty acid metabolism and the inhibition by in ovo feeding oleic acid in Muscovy duck embryogenesis.
Zhang X, Wu Q, Zheng W, Liu C, Huang L, Zuo X, Xiao W, Han X, Ye H, Wang W, Yang L, Zhu Y
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2023 Mar;12:321-333
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2023 Mar;12:321-333
Gamma-Muricholic Acid Inhibits Nonalcoholic Steatohepatitis: Abolishment of Steatosis-Dependent Peroxidative Impairment by FXR/SHP/LXRα/FASN Signaling.
Xie Y, Shen F, He Y, Guo C, Yang R, Cao H, Pan Q, Fan J
Nutrients 2023 Mar 2;15(5)
Nutrients 2023 Mar 2;15(5)
Docosahexaenoic Acid Alters Lipid Metabolism Processes via H3K9ac Epigenetic Modification in Dairy Goat.
Wu J, Luo J, He Q, Xia Y, Tian H, Zhu L, Li C, Loor JJ
Journal of agricultural and food chemistry 2023 Jun 7;71(22):8527-8539
Journal of agricultural and food chemistry 2023 Jun 7;71(22):8527-8539
Long noncoding RNAs with peptide-encoding potential identified in esophageal squamous cell carcinoma: KDM4A-AS1-encoded peptide weakens cancer cell viability and migratory capacity.
Zhou B, Wu Y, Cheng P, Wu C
Molecular oncology 2023 Jul;17(7):1419-1436
Molecular oncology 2023 Jul;17(7):1419-1436
Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1/2-PPARγ-Cd36 pathway.
Li L, Sun H, Chen J, Ding C, Yang X, Han H, Sun Q
Cell reports 2023 Jul 25;42(7):112697
Cell reports 2023 Jul 25;42(7):112697
Imbalance in ALR ubiquitination accelerates the progression of nonalcoholic steatohepatitis to hepatocellular carcinoma.
Zheng M, Ai Z, Guo Y, Chen Y, Xie P, An W
Oncogene 2023 Jan;42(4):308-321
Oncogene 2023 Jan;42(4):308-321
TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability.
Chen X, Yong H, Chen M, Deng C, Wang P, Chu S, Li M, Hou P, Zheng J, Li Z, Bai J
Journal of experimental & clinical cancer research : CR 2023 Jan 25;42(1):34
Journal of experimental & clinical cancer research : CR 2023 Jan 25;42(1):34
Enhanced De Novo Lipid Synthesis Mediated by FASN Induces Chemoresistance in Colorectal Cancer.
Han L, Dai W, Luo W, Ye L, Fang H, Mo S, Li Q, Xu Y, Wang R, Cai G
Cancers 2023 Jan 17;15(3)
Cancers 2023 Jan 17;15(3)
LncRNA-TBP mediates TATA-binding protein recruitment to regulate myogenesis and induce slow-twitch myofibers.
Ma M, Cai B, Zhou Z, Kong S, Zhang J, Xu H, Zhang X, Nie Q
Cell communication and signaling : CCS 2023 Jan 12;21(1):7
Cell communication and signaling : CCS 2023 Jan 12;21(1):7
CircRNA MBOAT2 promotes intrahepatic cholangiocarcinoma progression and lipid metabolism reprogramming by stabilizing PTBP1 to facilitate FASN mRNA cytoplasmic export.
Yu X, Tong H, Chen J, Tang C, Wang S, Si Y, Wang S, Tang Z
Cell death & disease 2023 Jan 12;14(1):20
Cell death & disease 2023 Jan 12;14(1):20
Protein kinase C epsilon promotes de novo lipogenesis and tumor growth in prostate cancer cells by regulating the phosphorylation and nuclear translocation of pyruvate kinase isoform M2.
Lai X, Liang Y, Jin J, Zhang H, Wu Z, Li G, Wang J, Zhang Z, Chen H, Zeng F, Deng F
Experimental cell research 2023 Jan 1;422(1):113427
Experimental cell research 2023 Jan 1;422(1):113427
Knockout of ICAT in Adipose Tissue Alleviates Fibro-inflammation in Obese Mice.
Song Z, Liu N, He Y, Chen J, Li J, Wang F, Wu Z
Inflammation 2023 Feb;46(1):404-417
Inflammation 2023 Feb;46(1):404-417
Docosahexaenoic acid reverses PD-L1-mediated immune suppression by accelerating its ubiquitin-proteasome degradation.
Zhang H, Chen H, Yin S, Fan L, Jin C, Zhao C, Hu H
The Journal of nutritional biochemistry 2023 Feb;112:109186
The Journal of nutritional biochemistry 2023 Feb;112:109186
L-Theanine regulates lipid metabolism by modulating gut microbiota and bile acid metabolism.
Xu W, Kong Y, Zhang T, Gong Z, Xiao W
Journal of the science of food and agriculture 2023 Feb;103(3):1283-1293
Journal of the science of food and agriculture 2023 Feb;103(3):1283-1293
Vitamin D Receptor Activation Attenuates Olanzapine-Induced Dyslipidemia in Mice Through Alleviating Hepatic Endoplasmic Reticulum Stress.
Dang R, Wang J, Tang M, Han W, Jiang P
Advanced biology 2023 Dec;7(12):e2300228
Advanced biology 2023 Dec;7(12):e2300228
Foxk1 stimulates adipogenic differentiation via a peroxisome proliferator-activated receptor gamma 2-dependent mechanism.
Zhang S, You Y, Li Y, Yuan H, Zhou J, Tian L, Liu Y, Wang B, Zhu E
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23266
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23266
Expression profile of FASN gene and association of its polymorphisms with intramuscular fat content in Hu sheep.
Liu C, Liu X, Yuan Z, Zhang X, Li F, Yue X
Animal biotechnology 2023 Dec;34(9):4347-4356
Animal biotechnology 2023 Dec;34(9):4347-4356
F6P/G6P-mediated ChREBP activation promotes the insulin resistance-driven hepatic lipid deposition in zebrafish.
Gong Y, Lu Q, Xi L, Liu Y, Yang B, Su J, Liu H, Jin J, Zhang Z, Yang Y, Zhu X, Xie S, Han D
The Journal of nutritional biochemistry 2023 Dec;122:109452
The Journal of nutritional biochemistry 2023 Dec;122:109452
Lonicerae flos polysaccharides improve nonalcoholic fatty liver disease by activating the adenosine 5'-monophosphate-activated protein kinase pathway and reshaping gut microbiota.
Han C, Li Z, Liu R, Zhao Z, Wang Y, Zuo X, Zhang Y, Geng Z, Huang H, Pan X, Li W
Journal of the science of food and agriculture 2023 Dec;103(15):7721-7738
Journal of the science of food and agriculture 2023 Dec;103(15):7721-7738
Senescence-associated 13-HODE production promotes age-related liver steatosis by directly inhibiting catalase activity.
Duan J, Dong W, Wang G, Xiu W, Pu G, Xu J, Ye C, Zhang X, Zhu Y, Wang C
Nature communications 2023 Dec 9;14(1):8151
Nature communications 2023 Dec 9;14(1):8151
LncHLEF promotes hepatic lipid synthesis through miR-2188-3p/GATA6 axis and encoding peptides and enhances intramuscular fat deposition via exosome.
Guo Y, Tian W, Wang D, Yang L, Wang Z, Wu X, Zhi Y, Zhang K, Wang Y, Li Z, Jiang R, Sun G, Li G, Tian Y, Wang H, Kang X, Liu X, Li H
International journal of biological macromolecules 2023 Dec 31;253(Pt 5):127061
International journal of biological macromolecules 2023 Dec 31;253(Pt 5):127061
Therapeutic protein PAK restrains the progression of triple negative breast cancer through degrading SREBP-1 mRNA.
Hu P, Zhou P, Sun T, Liu D, Yin J, Liu L
Breast cancer research : BCR 2023 Dec 11;25(1):151
Breast cancer research : BCR 2023 Dec 11;25(1):151
α-Lactalbumin Peptide Asp-Gln-Trp Ameliorates Hepatic Steatosis and Oxidative Stress in Free Fatty Acids-Treated HepG2 Cells and High-Fat Diet-Induced NAFLD Mice by Activating the PPARα Pathway.
Chen H, Ma Y, Qi X, Tian J, Ma Y, Niu T
Molecular nutrition & food research 2023 Aug;67(16):e2200499
Molecular nutrition & food research 2023 Aug;67(16):e2200499
Decreased Imiquimod-Induced Psoriasis-Like Skin Inflammation in a Novel Mvd(F250S/+) Knock-In Mouse Model.
La Y, Wong W, Peng K, Tian Z, Pan J, Sun R, Luan J, Yan K, Zhang Q, Zhang Z
Inflammation 2023 Aug;46(4):1575-1586
Inflammation 2023 Aug;46(4):1575-1586
Integrated multi-omics analyses reveal Jorunnamycin A as a novel suppressor for muscle-invasive bladder cancer by targeting FASN and TOP1.
Chen R, Hao X, Chen J, Zhang C, Fan H, Lian F, Chen X, Wang C, Xia Y
Journal of translational medicine 2023 Aug 16;21(1):549
Journal of translational medicine 2023 Aug 16;21(1):549
Cordycepin reprogramming lipid metabolism to block metastasis and EMT via ERO1A/mTOR/SREBP1 axis in cholangiocarcinoma.
Zhou X, Li Y, Yang C, Chen D, Wang T, Liu T, Yan W, Su Z, Peng B, Ren X
Life sciences 2023 Aug 15;327:121698
Life sciences 2023 Aug 15;327:121698
Epiberberine regulates lipid synthesis through SHP (NR0B2) to improve non-alcoholic steatohepatitis.
Zhou LM, Fan JH, Xu MM, Xiong MY, Wang QJ, Chai X, Li XD, Li XG, Ye XL
Biochimica et biophysica acta. Molecular basis of disease 2023 Apr;1869(4):166639
Biochimica et biophysica acta. Molecular basis of disease 2023 Apr;1869(4):166639
Protopanaxadiol ameliorates NAFLD by regulating hepatocyte lipid metabolism through AMPK/SIRT1 signaling pathway.
Li Y, Liu Y, Chen Z, Tang K, Yang L, Jiang Y, Wang J, Huang P, Wang J, Zheng P, Song H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Apr;160:114319
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Apr;160:114319
Tandem mass tag-based quantitative proteomics analysis reveals the effects of the α-lactalbumin peptides GINY and DQW on lipid deposition and oxidative stress in HepG2 cells.
Chen H, Qi X, Guan K, Wang R, Li Q, Ma Y
Journal of dairy science 2023 Apr;106(4):2271-2288
Journal of dairy science 2023 Apr;106(4):2271-2288
A UPLC-Q-TOF/MS and network pharmacology method to explore the mechanism of Anhua fuzhuan tea intervention in nonalcoholic fatty liver disease.
Tian FM, Yi J, Tang Y, Chen BW, Long HP, Liu YF, Ou-Yang Y, Zhang WJ, Tang RM, Liu BY
Food & function 2023 Apr 24;14(8):3686-3700
Food & function 2023 Apr 24;14(8):3686-3700
DAXX drives de novo lipogenesis and contributes to tumorigenesis.
Mahmud I, Tian G, Wang J, Hutchinson TE, Kim BJ, Awasthee N, Hale S, Meng C, Moore A, Zhao L, Lewis JE, Waddell A, Wu S, Steger JM, Lydon ML, Chait A, Zhao LY, Ding H, Li JL, Purayil HT, Huo Z, Daaka Y, Garrett TJ, Liao D
Nature communications 2023 Apr 12;14(1):1927
Nature communications 2023 Apr 12;14(1):1927
MiR-328-5p inhibits the adipogenic differentiation of hMSCs by targeting fatty acid synthase.
Li X, He S, Wu P, Zhou Y, Long K, Wang T
Folia histochemica et cytobiologica 2022;60(4):292-300
Folia histochemica et cytobiologica 2022;60(4):292-300
Profile analysis and functional modeling identify circular RNAs in nonalcoholic fatty liver disease as regulators of hepatic lipid metabolism.
Xie Y, Cao Y, Guo CJ, Guo XY, He YF, Xu QY, Shen F, Pan Q
Frontiers in genetics 2022;13:884037
Frontiers in genetics 2022;13:884037
D-Mannose Regulates Hepatocyte Lipid Metabolism via PI3K/Akt/mTOR Signaling Pathway and Ameliorates Hepatic Steatosis in Alcoholic Liver Disease.
Hu M, Chen Y, Deng F, Chang B, Luo J, Dong L, Lu X, Zhang Y, Chen Z, Zhou J
Frontiers in immunology 2022;13:877650
Frontiers in immunology 2022;13:877650
Effects of Poria cocos extract on metabolic dysfunction-associated fatty liver disease via the FXR/PPARα-SREBPs pathway.
He J, Yang Y, Zhang F, Li Y, Li X, Pu X, He X, Zhang M, Yang X, Yu Q, Qi Y, Li X, Yu J
Frontiers in pharmacology 2022;13:1007274
Frontiers in pharmacology 2022;13:1007274
PRMT5 confers lipid metabolism reprogramming, tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours.
Yuan HF, Zhao M, Zhao LN, Yun HL, Yang G, Geng Y, Wang YF, Zheng W, Yuan Y, Song TQ, Niu JQ, Zhang XD
Acta pharmacologica Sinica 2022 Sep;43(9):2373-2385
Acta pharmacologica Sinica 2022 Sep;43(9):2373-2385
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.
Dai W, Xiang W, Han L, Yuan Z, Wang R, Ma Y, Yang Y, Cai S, Xu Y, Mo S, Li Q, Cai G
Cancer communications (London, England) 2022 Sep;42(9):848-867
Cancer communications (London, England) 2022 Sep;42(9):848-867
A therapeutic DC vaccine with maintained immunological activity exhibits robust anti-tumor efficacy.
Lu Y, Shi Y, Liu Y, Luo Z, Zhang J, Jiang M, Li X, Liu X, Guo X, Qin B, Yin H, Du Y, Qiu Y, Lou Y, Guan G, Luo L, You J
Journal of controlled release : official journal of the Controlled Release Society 2022 Sep;349:254-268
Journal of controlled release : official journal of the Controlled Release Society 2022 Sep;349:254-268
Metabolic Syndrome Ameliorated by 4-Methylesculetin by Reducing Hepatic Lipid Accumulation.
Li L, Zhu G, Fu G, Zha W, Li H
International journal of molecular sciences 2022 Sep 9;23(18)
International journal of molecular sciences 2022 Sep 9;23(18)
Super-enhancer-associated INSM2 regulates lipid metabolism by modulating mTOR signaling pathway in neuroblastoma.
Cao H, Zhuo R, Zhang Z, Wang J, Tao Y, Yang R, Guo X, Chen Y, Jia S, Yao Y, Yang P, Yu J, Jiao W, Li X, Fang F, Xie Y, Li G, Wu D, Wang H, Feng C, Xu Y, Li Z, Pan J, Wang J
Cell & bioscience 2022 Sep 16;12(1):158
Cell & bioscience 2022 Sep 16;12(1):158
The role of hepatic Surf4 in lipoprotein metabolism and the development of atherosclerosis in apoE(-/-) mice.
Shen Y, Gu HM, Zhai L, Wang B, Qin S, Zhang DW
Biochimica et biophysica acta. Molecular and cell biology of lipids 2022 Oct;1867(10):159196
Biochimica et biophysica acta. Molecular and cell biology of lipids 2022 Oct;1867(10):159196
Cerulenin suppresses ErbB2-overexpressing breast cancer by targeting ErbB2/PKM2 pathway.
Lv S, Zhang Y, Song J, Chen J, Huang B, Luo Y, Zhao Y
Medical oncology (Northwood, London, England) 2022 Oct 29;40(1):5
Medical oncology (Northwood, London, England) 2022 Oct 29;40(1):5
Derepression of the USP22-FASN axis by p53 loss under oxidative stress drives lipogenesis and tumorigenesis.
Han Z, Liu M, Xie Y, Zeng K, Zhan Z, Chen Y, Wang L, Chen X, Luo Y, Zeng Y, Zhan H, Lin Y, Zhang K, Zhu X, Liu S, Luo X, Zhou A
Cell death discovery 2022 Nov 4;8(1):445
Cell death discovery 2022 Nov 4;8(1):445
circPRKAA1 activates a Ku80/Ku70/SREBP-1 axis driving de novo fatty acid synthesis in cancer cells.
Li Q, Yao H, Wang Y, Wu Y, Thorne RF, Zhu Y, Wu M, Liu L
Cell reports 2022 Nov 22;41(8):111707
Cell reports 2022 Nov 22;41(8):111707
Obesity promotes lipid accumulation in lymph node metastasis of gastric cancer: a retrospective case‒control study.
Xiao J, Shen K, Liu K, Wang Y, Fan H, Cheng Q, Zhou X, Hu L, Wang G, Xu Z, Yang L
Lipids in health and disease 2022 Nov 17;21(1):123
Lipids in health and disease 2022 Nov 17;21(1):123
FASN promotes lymph node metastasis in cervical cancer via cholesterol reprogramming and lymphangiogenesis.
Du Q, Liu P, Zhang C, Liu T, Wang W, Shang C, Wu J, Liao Y, Chen Y, Huang J, Tan H, Zhao Y, Xia M, Liu J, Yao S
Cell death & disease 2022 May 21;13(5):488
Cell death & disease 2022 May 21;13(5):488
Dietary L-arginine supplementation of tilapia (Oreochromis niloticus) alters the microbial population and activates intestinal fatty acid oxidation.
Li S, Wang C, Wu Z
Amino acids 2022 Mar;54(3):339-351
Amino acids 2022 Mar;54(3):339-351
Effects of maternal feed intake restriction on the blood parameters, fatty acid profile and lipogenetic genes expression of perirenal fat in offspring kids.
Chen W, Yang H, Yan Q, Zhou X, Tan Z, Wang Z
Animal reproduction science 2022 Mar;238:106955
Animal reproduction science 2022 Mar;238:106955
Psoralen Suppresses Lipid Deposition by Alleviating Insulin Resistance and Promoting Autophagy in Oleate-Induced L02 Cells.
Wang Y, Wang Y, Li F, Zou J, Li X, Xu M, Yu D, Ma Y, Huang W, Sun X, Zhang Y
Cells 2022 Mar 22;11(7)
Cells 2022 Mar 22;11(7)
Novel phosphanegold(I) thiolate complexes suppress de novo lipid synthesis in human lung cancer.
Luo M, Ma X, Jiang W, Zhang J, Liu W, Wei S, Liu H
European journal of medicinal chemistry 2022 Mar 15;232:114168
European journal of medicinal chemistry 2022 Mar 15;232:114168
CRISPR/Cas9-Induced Knockout of miR-24 Reduces Cholesterol and Monounsaturated Fatty Acid Content in Primary Goat Mammary Epithelial Cells.
Huang L, Luo J, Gao W, Song N, Tian H, Zhu L, Jiang Q, Loor JJ
Foods (Basel, Switzerland) 2022 Jul 7;11(14)
Foods (Basel, Switzerland) 2022 Jul 7;11(14)
Quantitative proteomic analysis of Bi Zhong Xiao decoction against collagen-induced arthritis rats in the early and late stages.
He C, Wang Y, Wen Y, Li T, Hu E, Zeng S, Xiong X
BMC complementary medicine and therapies 2022 Jul 13;22(1):186
BMC complementary medicine and therapies 2022 Jul 13;22(1):186
Scutellarin ameliorates hepatic lipid accumulation by enhancing autophagy and suppressing IRE1α/XBP1 pathway.
Zhang X, Huo Z, Luan H, Huang Y, Shen Y, Sheng L, Liang J, Wu F
Phytotherapy research : PTR 2022 Jan;36(1):433-447
Phytotherapy research : PTR 2022 Jan;36(1):433-447
MicroRNA-377-3p inhibits hepatocellular carcinoma growth and metastasis through negative regulation of CPT1C-mediated fatty acid oxidation.
Zhang T, Zhang Y, Liu J, Ma Y, Ye Q, Yan X, Ding L
Cancer & metabolism 2022 Jan 20;10(1):2
Cancer & metabolism 2022 Jan 20;10(1):2
Ginsenoside CK ameliorates hepatic lipid accumulation via activating the LKB1/AMPK pathway in vitro and in vivo.
Zhang J, Ma X, Fan D
Food & function 2022 Feb 7;13(3):1153-1167
Food & function 2022 Feb 7;13(3):1153-1167
Protein C receptor maintains cancer stem cell properties via activating lipid synthesis in nasopharyngeal carcinoma.
Zhang P, He Q, Wang Y, Zhou G, Chen Y, Tang L, Zhang Y, Hong X, Mao Y, He Q, Yang X, Liu N, Ma J
Signal transduction and targeted therapy 2022 Feb 16;7(1):46
Signal transduction and targeted therapy 2022 Feb 16;7(1):46
TiO(2) nanosheets promote the transformation of vascular smooth muscle cells into foam cells in vitro and in vivo through the up-regulation of nuclear factor kappa B subunit 2.
Li S, Yan D, Huang C, Yang F, Cao Y
Journal of hazardous materials 2022 Feb 15;424(Pt D):127704
Journal of hazardous materials 2022 Feb 15;424(Pt D):127704
Polyphyllin I improves myocardial damage in coronary artery disease via modulating lipid metabolism and myocardial apoptosis.
Yang Z, Yang X, An M
Journal of biochemical and molecular toxicology 2022 Dec;36(12):e23219
Journal of biochemical and molecular toxicology 2022 Dec;36(12):e23219
Di-2-ethylhexyl phthalate-induced miR-155-5p promoted lipid metabolism via inhibiting cAMP/PKA signaling pathway in human trophoblastic HTR-8/Svneo cells.
Gu X, Liu H, Luo W, Wang X, Wang H, Li L
Reproductive toxicology (Elmsford, N.Y.) 2022 Dec;114:22-31
Reproductive toxicology (Elmsford, N.Y.) 2022 Dec;114:22-31
Loss of Mature Lamin A/C Triggers a Shift in Intracellular Metabolic Homeostasis via AMPKα Activation.
Zhou Y, Yang JJ, Cheng Y, Feng GX, Yang RH, Yuan Y, Wang LY, Wang M, Kong L
Cells 2022 Dec 9;11(24)
Cells 2022 Dec 9;11(24)
Microalgae oil from Schizochytrium sp. alleviates obesity and modulates gut microbiota in high-fat diet-fed mice.
Ran L, Yu J, Ma R, Yao Q, Wang M, Bi Y, Yu Z, Wu Y
Food & function 2022 Dec 13;13(24):12799-12813
Food & function 2022 Dec 13;13(24):12799-12813
Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion.
Wang JQ, Li LL, Hu A, Deng G, Wei J, Li YF, Liu YB, Lu XY, Qiu ZP, Shi XJ, Zhao X, Luo J, Song BL
Nature 2022 Aug;608(7922):413-420
Nature 2022 Aug;608(7922):413-420
MiR-103-3p promotes hepatic steatosis to aggravate nonalcoholic fatty liver disease by targeting of ACOX1.
Ding J, Xia C, Cen P, Li S, Yu L, Zhu J, Jin J
Molecular biology reports 2022 Aug;49(8):7297-7305
Molecular biology reports 2022 Aug;49(8):7297-7305
Salvia-Nelumbinis naturalis improves lipid metabolism of NAFLD by regulating the SIRT1/AMPK signaling pathway.
Liu Y, Li Y, Wang J, Yang L, Yu X, Huang P, Song H, Zheng P
BMC complementary medicine and therapies 2022 Aug 9;22(1):213
BMC complementary medicine and therapies 2022 Aug 9;22(1):213
Functionalized gadofullerene ameliorates impaired glycolipid metabolism in type 2 diabetic mice.
Wu J, Chen Y, Li X, Ran L, Liu X, Wang X, Zhen M, Shao S, Zeng L, Wang C, Liang B, Zhao J, Wu Y
Journal of genetics and genomics = Yi chuan xue bao 2022 Apr;49(4):364-376
Journal of genetics and genomics = Yi chuan xue bao 2022 Apr;49(4):364-376
Long noncoding RNA ZFP36L2-AS functions as a metabolic modulator to regulate muscle development.
Cai B, Ma M, Zhang J, Kong S, Zhou Z, Li Z, Abdalla BA, Xu H, Zhang X, Lawal RA, Nie Q
Cell death & disease 2022 Apr 21;13(4):389
Cell death & disease 2022 Apr 21;13(4):389
RNF8 up-regulates AR/ARV7 action to contribute to advanced prostate cancer progression.
Zhou T, Wang S, Song X, Liu W, Dong F, Huo Y, Zou R, Wang C, Zhang S, Liu W, Sun G, Lin L, Zeng K, Dong X, Guo Q, Yi F, Wang Z, Li X, Jiang B, Cao L, Zhao Y
Cell death & disease 2022 Apr 15;13(4):352
Cell death & disease 2022 Apr 15;13(4):352
LYAR Promotes Colorectal Cancer Progression by Upregulating FSCN1 Expression and Fatty Acid Metabolism.
Wu Y, Zhou Y, Gao H, Wang Y, Cheng Q, Jian S, Ding Q, Gu W, Yao Y, Ma J, Wu W, Li Y, Tong X, Song X, Ma S
Oxidative medicine and cellular longevity 2021;2021:9979707
Oxidative medicine and cellular longevity 2021;2021:9979707
The Mutual Inhibition of FoxO1 and SREBP-1c Regulated the Progression of Hepatoblastoma by Regulating Fatty Acid Metabolism.
Hu Y, Zai H, Jiang W, Ou Z, Yao Y, Zhu Q
Mediators of inflammation 2021;2021:5754592
Mediators of inflammation 2021;2021:5754592
PRPF6 promotes androgen receptor/androgen receptor-variant 7 actions in castration-resistant prostate cancer cells.
Liu W, Wang C, Wang S, Zeng K, Wei S, Sun N, Sun G, Wang M, Zou R, Liu W, Lin L, Song H, Jin Z, Zhao Y
International journal of biological sciences 2021;17(1):188-203
International journal of biological sciences 2021;17(1):188-203
SOAT1 Promotes Gastric Cancer Lymph Node Metastasis Through Lipid Synthesis.
Zhu T, Wang Z, Zou T, Xu L, Zhang S, Chen Y, Chen C, Zhang W, Wang S, Ding Q, Xu G
Frontiers in pharmacology 2021;12:769647
Frontiers in pharmacology 2021;12:769647
High-Salt Attenuates the Efficacy of Dapagliflozin in Tubular Protection by Impairing Fatty Acid Metabolism in Diabetic Kidney Disease.
Zou M, Chen Y, Zheng Z, Sheng S, Jia Y, Wang X, Ren S, Yang Y, Li X, Dong W, Guan M, Zhang Q, Xue Y
Frontiers in pharmacology 2021;12:741087
Frontiers in pharmacology 2021;12:741087
Pterostilbene attenuates RIPK3-dependent hepatocyte necroptosis in alcoholic liver disease via SIRT2-mediated NFATc4 deacetylation.
Shao Y, Wang X, Zhou Y, Jiang Y, Wu R, Lu C
Toxicology 2021 Sep;461:152923
Toxicology 2021 Sep;461:152923
Deficiency of intestinal Bmal1 prevents obesity induced by high-fat feeding.
Yu F, Wang Z, Zhang T, Chen X, Xu H, Wang F, Guo L, Chen M, Liu K, Wu B
Nature communications 2021 Sep 7;12(1):5323
Nature communications 2021 Sep 7;12(1):5323
Novel SREBP1 inhibitor cinobufotalin suppresses proliferation of hepatocellular carcinoma by targeting lipogenesis.
Meng H, Shen M, Li J, Zhang R, Li X, Zhao L, Huang G, Liu J
European journal of pharmacology 2021 Sep 5;906:174280
European journal of pharmacology 2021 Sep 5;906:174280
Comprehensive multi-omics approaches reveal the hepatotoxic mechanism of perfluorohexanoic acid (PFHxA) in mice.
Jiang L, Hong Y, Xie G, Zhang J, Zhang H, Cai Z
The Science of the total environment 2021 Oct 10;790:148160
The Science of the total environment 2021 Oct 10;790:148160
Exercise improves lipid metabolism disorders induced by high-fat diet in a SESN2/JNK-independent manner.
Wang T, Hu W, Niu Y, Liu S, Fu L
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2021 Nov;46(11):1322-1330
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2021 Nov;46(11):1322-1330
Changes of lipid profiles in human umbilical vein endothelial cells exposed to zirconia nanoparticles with or without the presence of free fatty acids.
Cheng X, Guo H, Xian Y, Xie X
Journal of applied toxicology : JAT 2021 May;41(5):765-774
Journal of applied toxicology : JAT 2021 May;41(5):765-774
Lipid metabolism regulator human hydroxysteroid dehydrogenase-like 2 (HSDL2) modulates cervical cancer cell proliferation and metastasis.
Yang Y, Han A, Wang X, Yin X, Cui M, Lin Z
Journal of cellular and molecular medicine 2021 May;25(10):4846-4859
Journal of cellular and molecular medicine 2021 May;25(10):4846-4859
Apple polyphenol extract alleviates lipid accumulation in free-fatty-acid-exposed HepG2 cells via activating autophagy mediated by SIRT1/AMPK signaling.
Li D, Cui Y, Wang X, Liu F, Li X
Phytotherapy research : PTR 2021 Mar;35(3):1416-1431
Phytotherapy research : PTR 2021 Mar;35(3):1416-1431
Inhibition of lipogenesis and induction of apoptosis by valproic acid in prostate cancer cells via the C/EBPα/SREBP-1 pathway.
Pang B, Zhang J, Zhang X, Yuan J, Shi Y, Qiao L
Acta biochimica et biophysica Sinica 2021 Mar 2;53(3):354-364
Acta biochimica et biophysica Sinica 2021 Mar 2;53(3):354-364
Gu-Ben-Fang-Xiao decoction modulates lipid metabolism by activating the AMPK pathway in asthma remission.
You YN, Xing QQ, Zhao X, Ji JJ, Yan H, Zhou T, Dong YM, Ren LS, Hou ST, Ding YY
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111403
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111403
BMP4-mediated browning of perivascular adipose tissue governs an anti-inflammatory program and prevents atherosclerosis.
Mu W, Qian S, Song Y, Yang L, Song S, Yang Q, Liu H, Liu Y, Pan D, Tang Y, Tang QQ
Redox biology 2021 Jul;43:101979
Redox biology 2021 Jul;43:101979
Comparison of multi-walled carbon nanotubes and halloysite nanotubes on lipid profiles in human umbilical vein endothelial cells.
Liu Y, Hu Q, Huang C, Cao Y
NanoImpact 2021 Jul;23:100333
NanoImpact 2021 Jul;23:100333
Disrupted glucose homeostasis and skeletal-muscle-specific glucose uptake in an exocyst knockout mouse model.
Fujimoto BA, Young M, Nakamura N, Ha H, Carter L, Pitts MW, Torres D, Noh HL, Suk S, Kim JK, Polgar N
The Journal of biological chemistry 2021 Jan-Jun;296:100482
The Journal of biological chemistry 2021 Jan-Jun;296:100482
Transcriptomic analysis suggested the involvement of impaired lipid droplet biogenesis in graphene oxide-induced cytotoxicity in human umbilical vein endothelial cells.
Luo Y, Wang X, Cao Y
Chemico-biological interactions 2021 Jan 5;333:109325
Chemico-biological interactions 2021 Jan 5;333:109325
Dexmedetomidine ameliorates high-fat diet-induced nonalcoholic fatty liver disease by targeting SCD1 in obesity mice.
Tao L, Guo X, Xu M, Wang Y, Xie W, Chen H, Ma M, Li X
Pharmacology research & perspectives 2021 Feb;9(1):e00700
Pharmacology research & perspectives 2021 Feb;9(1):e00700
A small molecule targeting ALOX12-ACC1 ameliorates nonalcoholic steatohepatitis in mice and macaques.
Zhang XJ, Ji YX, Cheng X, Cheng Y, Yang H, Wang J, Zhao LP, Huang YP, Sun D, Xiang H, Shen LJ, Li PL, Ma JP, Tian RF, Yang J, Yao X, Xu H, Liao R, Xiao L, Zhang P, Zhang X, Zhao GN, Wang X, Hu ML, Tian S, Wan J, Cai J, Ma X, Xu Q, Wang Y, Touyz RM, Liu PP, Loomba R, She ZG, Li H
Science translational medicine 2021 Dec 15;13(624):eabg8116
Science translational medicine 2021 Dec 15;13(624):eabg8116
TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis.
Huang D, Xu B, Liu L, Wu L, Zhu Y, Ghanbarpour A, Wang Y, Chen FJ, Lyu J, Hu Y, Kang Y, Zhou W, Wang X, Ding W, Li X, Jiang Z, Chen J, Zhang X, Zhou H, Li JZ, Guo C, Zheng W, Zhang X, Li P, Melia T, Reinisch K, Chen XW
Cell metabolism 2021 Aug 3;33(8):1655-1670.e8
Cell metabolism 2021 Aug 3;33(8):1655-1670.e8
Betaine prevented high-fat diet-induced NAFLD by regulating the FGF10/AMPK signaling pathway in ApoE(-/-) mice.
Chen W, Zhang X, Xu M, Jiang L, Zhou M, Liu W, Chen Z, Wang Y, Zou Q, Wang L
European journal of nutrition 2021 Apr;60(3):1655-1668
European journal of nutrition 2021 Apr;60(3):1655-1668
Four sesquiterpene glycosides from loquat (Eriobotrya japonica) leaf ameliorates palmitic acid-induced insulin resistance and lipid accumulation in HepG2 Cells via AMPK signaling pathway.
Li J, Ding X, Jian T, Lü H, Zhao L, Li J, Liu Y, Ren B, Chen J
PeerJ 2020;8:e10413
PeerJ 2020;8:e10413
Mogroside V Protects against Hepatic Steatosis in Mice on a High-Fat Diet and LO2 Cells Treated with Free Fatty Acids via AMPK Activation.
Li L, Zheng W, Wang C, Qi J, Li H
Evidence-based complementary and alternative medicine : eCAM 2020;2020:7826874
Evidence-based complementary and alternative medicine : eCAM 2020;2020:7826874
LncRNA DNAJC3-AS1 Regulates Fatty Acid Synthase via the EGFR Pathway to Promote the Progression of Colorectal Cancer.
Tang Y, Tang R, Tang M, Huang P, Liao Z, Zhou J, Zhou L, Su M, Chen P, Jiang J, Hu Y, Zhou Y, Liao Q, Zeng Z, Xiong W, Chen J, Nie S
Frontiers in oncology 2020;10:604534
Frontiers in oncology 2020;10:604534
L-Theanine affects intestinal mucosal immunity by regulating short-chain fatty acid metabolism under dietary fiber feeding.
Xu W, Lin L, Liu A, Zhang T, Zhang S, Li Y, Chen J, Gong Z, Liu Z, Xiao W
Food & function 2020 Sep 23;11(9):8369-8379
Food & function 2020 Sep 23;11(9):8369-8379
Disruption of Plin5 degradation by CMA causes lipid homeostasis imbalance in NAFLD.
Ma SY, Sun KS, Zhang M, Zhou X, Zheng XH, Tian SY, Liu YS, Chen L, Gao X, Ye J, Zhou XM, Wang JB, Han Y
Liver international : official journal of the International Association for the Study of the Liver 2020 Oct;40(10):2427-2438
Liver international : official journal of the International Association for the Study of the Liver 2020 Oct;40(10):2427-2438
Fatty acid synthase contributes to epithelial-mesenchymal transition and invasion of salivary adenoid cystic carcinoma through PRRX1/Wnt/β-catenin pathway.
Zhang WL, Wang SS, Jiang YP, Liu Y, Yu XH, Wu JB, Wang K, Pang X, Liao P, Liang XH, Tang YL
Journal of cellular and molecular medicine 2020 Oct;24(19):11465-11476
Journal of cellular and molecular medicine 2020 Oct;24(19):11465-11476
Effect and mechanism of ginsenoside Rg1-regulating hepatic steatosis in HepG2 cells induced by free fatty acid.
Gao Y, Zhang S, Li J, Zhao J, Xiao Q, Zhu Y, Zhang J, Huang W
Bioscience, biotechnology, and biochemistry 2020 Nov;84(11):2228-2240
Bioscience, biotechnology, and biochemistry 2020 Nov;84(11):2228-2240
Modulation of SIRT1-mediated signaling cascades in the liver contributes to the amelioration of nonalcoholic steatohepatitis in high fat fed middle-aged LDL receptor knockout mice by dihydromyricetin.
Zeng Y, Hua YQ, Wang W, Zhang H, Xu XL
Biochemical pharmacology 2020 May;175:113927
Biochemical pharmacology 2020 May;175:113927
Dlgap1 negatively regulates browning of white fat cells through effects on cell proliferation and apoptosis.
Zhang J, Yang J, Yang N, Ma J, Lu D, Dong Y, Liang H, Liu D, Cang M
Lipids in health and disease 2020 Mar 13;19(1):39
Lipids in health and disease 2020 Mar 13;19(1):39
The lncRNA Gm15622 stimulates SREBP-1c expression and hepatic lipid accumulation by sponging the miR-742-3p in mice.
Ma M, Duan R, Shen L, Liu M, Ji Y, Zhou H, Li C, Liang T, Li X, Guo L
Journal of lipid research 2020 Jul;61(7):1052-1064
Journal of lipid research 2020 Jul;61(7):1052-1064
Association between different levels of lipid metabolism‑related enzymes and fatty acid synthase in Wilms' tumor.
Wang X, Du G, Wu Y, Zhang Y, Guo F, Liu W, Wu R
International journal of oncology 2020 Feb;56(2):568-580
International journal of oncology 2020 Feb;56(2):568-580
Effects of di (2-ethylhexyl) phthalate and high-fat diet on lipid metabolism in rats by JAK2/STAT5.
Zhang Y, Zhou L, Zhang Z, Xu Q, Han X, Zhao Y, Song X, Zhao T, Ye L
Environmental science and pollution research international 2020 Feb;27(4):3837-3848
Environmental science and pollution research international 2020 Feb;27(4):3837-3848
Dihydroartemisinin inhibits endothelial cell tube formation by suppression of the STAT3 signaling pathway.
Gao P, Wang LL, Liu J, Dong F, Song W, Liao L, Wang B, Zhang W, Zhou X, Xie Q, Sun R, Liu J
Life sciences 2020 Feb 1;242:117221
Life sciences 2020 Feb 1;242:117221
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
Fu Y, Sun Y, Wang M, Hou Y, Huang W, Zhou D, Wang Z, Yang S, Tang W, Zhen J, Li Y, Wang X, Liu M, Zhang Y, Wang B, Liu G, Yu X, Sun J, Zhang C, Yi F
Cell metabolism 2020 Dec 1;32(6):1052-1062.e8
Cell metabolism 2020 Dec 1;32(6):1052-1062.e8
Responses of intestinal morphology and function in offspring to heat stress in primiparous sows during late gestation.
Guo H, He J, Yang X, Zheng W, Yao W
Journal of thermal biology 2020 Apr;89:102539
Journal of thermal biology 2020 Apr;89:102539
Identification of aberrantly methylated differentially expressed genes in prostate carcinoma using integrated bioinformatics.
Wu K, Yin X, Jin Y, Liu F, Gao J
Cancer cell international 2019;19:51
Cancer cell international 2019;19:51
Downregulation of PDK4 Increases Lipogenesis and Associates with Poor Prognosis in Hepatocellular Carcinoma.
Yang C, Wang S, Ruan H, Li B, Cheng Z, He J, Zuo Q, Yu C, Wang H, Lv Y, Gu D, Jin G, Yao M, Qin W, Jin H
Journal of Cancer 2019;10(4):918-926
Journal of Cancer 2019;10(4):918-926
A Novel Regulatory Circuit "C/EBPα/miR-20a-5p/TOB2" Regulates Adipogenesis and Lipogenesis.
Zhou J, Yang J, Wang X, Li M, Li F, Zhu E, Li X, Li X, Wang B
Frontiers in endocrinology 2019;10:894
Frontiers in endocrinology 2019;10:894
Emodin Induced SREBP1-Dependent and SREBP1-Independent Apoptosis in Hepatocellular Carcinoma Cells.
Yang N, Li C, Li H, Liu M, Cai X, Cao F, Feng Y, Li M, Wang X
Frontiers in pharmacology 2019;10:709
Frontiers in pharmacology 2019;10:709
Sorafenib kills liver cancer cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids via the ATP-AMPK-mTOR-SREBP1 signaling pathway.
Liu G, Kuang S, Cao R, Wang J, Peng Q, Sun C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Sep;33(9):10089-10103
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Sep;33(9):10089-10103
Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1.
Zhang Y, Li C, Hu C, Wu Q, Cai Y, Xing S, Lu H, Wang L, Huang D, Sun L, Li T, He X, Zhong X, Wang J, Gao P, Smith ZJ, Jia W, Zhang H
EMBO reports 2019 Oct 4;20(10):e48115
EMBO reports 2019 Oct 4;20(10):e48115
The metabolic regulator small heterodimer partner contributes to the glucose and lipid homeostasis abnormalities induced by hepatitis C virus infection.
Chen J, Zhou Y, Zhuang Y, Qin T, Guo M, Jiang J, Niu J, Li JZ, Chen X, Wang Q
Metabolism: clinical and experimental 2019 Nov;100:153954
Metabolism: clinical and experimental 2019 Nov;100:153954
Hepatitis C virus nonstructural protein 5A perturbs lipid metabolism by modulating AMPK/SREBP-1c signaling.
Meng Z, Liu Q, Sun F, Qiao L
Lipids in health and disease 2019 Nov 4;18(1):191
Lipids in health and disease 2019 Nov 4;18(1):191
Mono-2-ethylhexyl phthalate (MEHP) promoted lipid accumulation via JAK2/STAT5 and aggravated oxidative stress in BRL-3A cells.
Zhang Y, Wang S, Zhao T, Yang L, Guo S, Shi Y, Zhang X, Zhou L, Ye L
Ecotoxicology and environmental safety 2019 Nov 30;184:109611
Ecotoxicology and environmental safety 2019 Nov 30;184:109611
Inhibition of fatty acid synthesis arrests colorectal neoplasm growth and metastasis: Anti-cancer therapeutical effects of natural cyclopeptide RA-XII.
Wang Y, Guo D, He J, Song L, Chen H, Zhang Z, Tan N
Biochemical and biophysical research communications 2019 May 14;512(4):819-824
Biochemical and biophysical research communications 2019 May 14;512(4):819-824
Di (2-ethylhexyl) phthalate Disorders Lipid Metabolism via TYK2/STAT1 and Autophagy in Rats.
Zhang YZ, Zhang ZM, Zhou LT, Zhu J, Zhang XH, Qi W, Ding S, Xu Q, Han X, Zhao YM, Song XY, Zhao TY, Ye L
Biomedical and environmental sciences : BES 2019 Jun;32(6):406-418
Biomedical and environmental sciences : BES 2019 Jun;32(6):406-418
Mono-2-ethylhexyl phthalate induces the expression of genes involved in fatty acid synthesis in HepG2 cells.
Bai J, He Z, Li Y, Jiang X, Yu H, Tan Q
Environmental toxicology and pharmacology 2019 Jul;69:104-111
Environmental toxicology and pharmacology 2019 Jul;69:104-111
Effect of selenium nanoparticles against abnormal fatty acid metabolism induced by hexavalent chromium in chicken's liver.
Luo M, Huang S, Zhang J, Zhang L, Mehmood K, Jiang J, Zhang N, Zhou D
Environmental science and pollution research international 2019 Jul;26(21):21828-21834
Environmental science and pollution research international 2019 Jul;26(21):21828-21834
Lingguizhugan decoction attenuates diet-induced obesity and hepatosteatosis via gut microbiota.
Liu MT, Huang YJ, Zhang TY, Tan LB, Lu XF, Qin J
World journal of gastroenterology 2019 Jul 21;25(27):3590-3606
World journal of gastroenterology 2019 Jul 21;25(27):3590-3606
Multi-walled carbon nanotubes promoted lipid accumulation in human aortic smooth muscle cells.
Yang H, Li J, Yang C, Liu H, Cao Y
Toxicology and applied pharmacology 2019 Jul 1;374:11-19
Toxicology and applied pharmacology 2019 Jul 1;374:11-19
Cancer‑associated adipocytes exhibit distinct phenotypes and facilitate tumor progression in pancreatic cancer.
Cai Z, Liang Y, Xing C, Wang H, Hu P, Li J, Huang H, Wang W, Jiang C
Oncology reports 2019 Dec;42(6):2537-2549
Oncology reports 2019 Dec;42(6):2537-2549
Porphyromonas gingivalis Promotes 4-Nitroquinoline-1-Oxide-Induced Oral Carcinogenesis With an Alteration of Fatty Acid Metabolism.
Wu JS, Zheng M, Zhang M, Pang X, Li L, Wang SS, Yang X, Wu JB, Tang YJ, Tang YL, Liang XH
Frontiers in microbiology 2018;9:2081
Frontiers in microbiology 2018;9:2081
Brg1 regulates pro-lipogenic transcription by modulating SREBP activity in hepatocytes.
Li N, Li M, Hong W, Shao J, Xu H, Shimano H, Lu J, Xu Y
Biochimica et biophysica acta. Molecular basis of disease 2018 Sep;1864(9 Pt B):2881-2889
Biochimica et biophysica acta. Molecular basis of disease 2018 Sep;1864(9 Pt B):2881-2889
RNA-binding proteins and heat-shock protein 90 are constituents of the cytoplasmic capping enzyme interactome.
Trotman JB, Agana BA, Giltmier AJ, Wysocki VH, Schoenberg DR
The Journal of biological chemistry 2018 Oct 26;293(43):16596-16607
The Journal of biological chemistry 2018 Oct 26;293(43):16596-16607
Inhibition of androgen receptor transactivation function by adenovirus type 12 E1A undermines prostate cancer cell survival.
Li D, Tian G, Wang J, Zhao LY, Co O, Underill ZC, Mymryk JS, Claessens F, Dehm SM, Daaka Y, Liao D
The Prostate 2018 Nov;78(15):1140-1156
The Prostate 2018 Nov;78(15):1140-1156
Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues.
Wallace M, Green CR, Roberts LS, Lee YM, McCarville JL, Sanchez-Gurmaches J, Meurs N, Gengatharan JM, Hover JD, Phillips SA, Ciaraldi TP, Guertin DA, Cabrales P, Ayres JS, Nomura DK, Loomba R, Metallo CM
Nature chemical biology 2018 Nov;14(11):1021-1031
Nature chemical biology 2018 Nov;14(11):1021-1031
Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice.
Chen S, Li X, Liu L, Liu C, Han X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Mar;32(3):1139-1153
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Mar;32(3):1139-1153
Effect of Dibutyltin Dilaurate on Triglyceride Metabolism through the Inhibition of the mTOR Pathway in Human HL7702 Liver Cells.
Qiao X, Li Y, Mai J, Ji X, Li Q
Molecules (Basel, Switzerland) 2018 Jul 6;23(7)
Molecules (Basel, Switzerland) 2018 Jul 6;23(7)
Adipose-specific lipin1 overexpression in mice protects against alcohol-induced liver injury.
Zhang W, Zhong W, Sun Q, Sun X, Zhou Z
Scientific reports 2018 Jan 11;8(1):408
Scientific reports 2018 Jan 11;8(1):408
Effects of calycosin against high-fat diet-induced nonalcoholic fatty liver disease in mice.
Duan X, Meng Q, Wang C, Liu Z, Sun H, Huo X, Sun P, Ma X, Peng J, Liu K
Journal of gastroenterology and hepatology 2018 Feb;33(2):533-542
Journal of gastroenterology and hepatology 2018 Feb;33(2):533-542
GLP-1/GLP-1R Signaling in Regulation of Adipocyte Differentiation and Lipogenesis.
Chen J, Zhao H, Ma X, Zhang Y, Lu S, Wang Y, Zong C, Qin D, Wang Y, Yingfeng Yang Y, Wang X, Liu Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;42(3):1165-1176
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;42(3):1165-1176
Lack of β, β-carotene-9', 10'-oxygenase 2 leads to hepatic mitochondrial dysfunction and cellular oxidative stress in mice.
Wu L, Guo X, Hartson SD, Davis MA, He H, Medeiros DM, Wang W, Clarke SL, Lucas EA, Smith BJ, von Lintig J, Lin D
Molecular nutrition & food research 2017 May;61(5)
Molecular nutrition & food research 2017 May;61(5)
Embelin attenuates adipogenesis and lipogenesis through activating canonical Wnt signaling and inhibits high-fat diet-induced obesity.
Gao Y, Li J, Xu X, Wang S, Yang Y, Zhou J, Zhang L, Zheng F, Li X, Wang B
International journal of obesity (2005) 2017 May;41(5):729-738
International journal of obesity (2005) 2017 May;41(5):729-738
Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission.
Wang L, Zhang T, Wang L, Cai Y, Zhong X, He X, Hu L, Tian S, Wu M, Hui L, Zhang H, Gao P
The EMBO journal 2017 May 15;36(10):1330-1347
The EMBO journal 2017 May 15;36(10):1330-1347
Mitochondrial toxicity of perfluorooctane sulfonate in mouse embryonic stem cell-derived cardiomyocytes.
Tang LL, Wang JD, Xu TT, Zhao Z, Zheng JJ, Ge RS, Zhu DY
Toxicology 2017 May 1;382:108-116
Toxicology 2017 May 1;382:108-116
Alisol B 23-acetate protects against non-alcoholic steatohepatitis in mice via farnesoid X receptor activation.
Meng Q, Duan XP, Wang CY, Liu ZH, Sun PY, Huo XK, Sun HJ, Peng JY, Liu KX
Acta pharmacologica Sinica 2017 Jan;38(1):69-79
Acta pharmacologica Sinica 2017 Jan;38(1):69-79
Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin.
Xue C, Wang C, Sun Y, Meng Q, Liu Z, Huo X, Sun P, Sun H, Ma X, Ma X, Peng J, Liu K
Oncotarget 2017 Jan 31;8(5):8622-8632
Oncotarget 2017 Jan 31;8(5):8622-8632
B7-H3 regulates lipid metabolism of lung cancer through SREBP1-mediated expression of FASN.
Luo D, Xiao H, Dong J, Li Y, Feng G, Cui M, Fan S
Biochemical and biophysical research communications 2017 Jan 22;482(4):1246-1251
Biochemical and biophysical research communications 2017 Jan 22;482(4):1246-1251
Calycosin attenuates triglyceride accumulation and hepatic fibrosis in murine model of non-alcoholic steatohepatitis via activating farnesoid X receptor.
Duan X, Meng Q, Wang C, Liu Z, Liu Q, Sun H, Sun P, Yang X, Huo X, Peng J, Liu K
Phytomedicine : international journal of phytotherapy and phytopharmacology 2017 Feb 15;25:83-92
Phytomedicine : international journal of phytotherapy and phytopharmacology 2017 Feb 15;25:83-92
Formaldehyde alters triglyceride synthesis and very low-density lipoprotein secretion in a time-dependent manner.
Bai J, Wang P, Liu Y, Zhang Y, Li Y, He Z, Hou L, Liang R
Environmental toxicology and pharmacology 2017 Dec;56:15-20
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 10624-2-AP(FASN antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using FASN antibody 10624-2-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-FASN (IP:10624-2-AP, 4ug; Detection:10624-2-AP 1:500) with mouse liver tissue lysate 4000ug.
- Sample type
- tissue
