66591-1-Ig

antibody from Proteintech Group

Targeting: FASN FAS, SDR27X1

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

66591-1-Ig

Provider

Proteintech Group

Product name

FASN antibody

Antibody type

Monoclonal

Description

FASN antibody (Cat. #66591-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human and has been validated for the following applications: IF, IHC, WB, ELISA.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

1B6E4

Vial size

20ul, 150ul

References

Submitted references

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International journal of biological sciences 2026;22(3):1590-1610

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ANXA1 overexpression promotes B cell acute lymphoblastic leukemia progression and resistance by regulating fatty acid metabolism through PI3K/Akt signaling.

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Molecular and cellular biochemistry 2026 Mar;481(3):1401-1414

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Liver-Targeting Nanoparticles GA-MSe@AR Treat NAFLD Through Dual Lipid-Lowering and Antioxidant Efficacy.

Lei S, Wu Q, Zhang B, Lu M, Xia Y, Li N
International journal of nanomedicine 2025;20:5017-5037

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The IGF2BP3-FASN axis drives lipid metabolic reprogramming to promote brain colonization in non-small cell lung cancer.

Li J, Ouyang S, Lin Z, Peng K, Yan J, Lu M, Ding W, Mo J, Su Y, Wang L, Yue P, Lu JJ, Yao X, Wang Y, Zhang X
Cell death & disease 2025 Oct 6;16(1):684

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Role of a low-molecular-weight polysaccharide from Boletus edulis Bull: Fr. in modulating gut microbiota and metabolic disorders.

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International journal of biological macromolecules 2025 May;309(Pt 3):142789

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Multi-omics joint analysis: Pachymic acid ameliorated non-alcoholic fatty liver disease by regulating gut microbiota.

Ren G, Lin Y, Fu Y, Liu F, Wang R, Zhang C, Qiu J, Chen L, Dou X
Food research international (Ottawa, Ont.) 2025 May;209:116178

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Radiation Promotes Acute and Chronic Damage to Adipose Tissue.

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International journal of molecular sciences 2025 Jun 12;26(12)

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Hericium erinaceus Protein Alleviates High-Fat Diet-Induced Hepatic Lipid Accumulation and Oxidative Stress In Vivo.

Lu H, Yang S, Li W, Zheng B, Zeng S, Chen H
Foods (Basel, Switzerland) 2025 Jan 31;14(3)

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Hepatoblastoma-Derived Exosomal FASN Affected the Differentiation of Hepatic Stellate Cells Into Cancer-Associated Fibroblasts by Regulating the Stability of HK2 and Mediating Histone Lactylation.

Zhu Q, Zhou Y, Wang Y, Wu X, Hu Y, Zai H
Comprehensive Physiology 2025 Dec;15(6):e70080

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Riboflavin-PLGA nanoparticles enhance the effectiveness of the pyruvate carboxylase inhibitor ZY-444 in targeting lipogenesis in colon and breast cancer.

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FGF21-MAPK1 Imbalance Disrupts Hepatic Lipid Metabolism in Dairy Cow Ketosis.

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Life (Basel, Switzerland) 2025 Aug 24;15(9)

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SESN2 maintains cartilage homeostasis by SREBP1-mediated lipid metabolism during osteoarthritis progression.

Liu Z, Jiang H, Zhang Z, Jiang R, Wang R, Li J, Li W, Tan G, Fei Y, Lv Z, Guo H, Sun Z, Wu R, Shi H, Shi D
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Jatrorrhizine retard obesity by modulating transcription factor c-Jun/c-Fos to downregulate Mmp12-mediated inflammation.

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siRNA nanoparticle targeting Usp20 lowers lipid levels and ameliorates metabolic syndrome in mice.

Ding Y, Chen QB, Xu H, Adi D, Ding YW, Luo WJ, Zhu WZ, Xu JC, Zhao X, Shi XJ, Luo J, Yin H, Lu XY
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USP14 increases the sensitivity of retinoblastoma to cisplatin by mediating the ferroptosis.

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Let-7a-5p abrogates progression of papillary thyroid carcinoma cells by decreasing nuclear receptor subfamily 6 group a member 1-mediated lipogenesis.

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Journal of biochemical and molecular toxicology 2024 Jan;38(1):e23572

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TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis.

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Journal of translational medicine 2024 Jan 2;22(1):6

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Metabolic reprogramming based on RNA sequencing of gemcitabine-resistant cells reveals the FASN gene as a therapeutic for bladder cancer.

Zhou L, Du K, Dai Y, Zeng Y, Luo Y, Ren M, Pan W, Liu Y, Zhang L, Zhu R, Feng D, Tian F, Gu C
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ZDHHC20 mediated S-palmitoylation of fatty acid synthase (FASN) promotes hepatocarcinogenesis.

Mo Y, Han Y, Chen Y, Fu C, Li Q, Liu Z, Xiao M, Xu B
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American journal of cancer research 2022;12(6):2686-2696

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CRISPR Cas9-mediated ablation of pyruvate carboxylase gene in colon cancer cell line HT-29 inhibits growth and migration, induces apoptosis and increases sensitivity to 5-fluorouracil and glutaminase inhibitor.

Ngamkham J, Siritutsoontorn S, Saisomboon S, Vaeteewoottacharn K, Jitrapakdee S
Frontiers in oncology 2022;12:966089

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Derepression of the USP22-FASN axis by p53 loss under oxidative stress drives lipogenesis and tumorigenesis.

Han Z, Liu M, Xie Y, Zeng K, Zhan Z, Chen Y, Wang L, Chen X, Luo Y, Zeng Y, Zhan H, Lin Y, Zhang K, Zhu X, Liu S, Luo X, Zhou A
Cell death discovery 2022 Nov 4;8(1):445

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SIRT1/mTOR pathway-mediated autophagy dysregulation promotes Pb-induced hepatic lipid accumulation in HepG2 cells.

Zhao Y, Mao A, Zhang R, Guan S, Lu J
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Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription.

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OGDHL silencing promotes hepatocellular carcinoma by reprogramming glutamine metabolism.

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Journal of hepatology 2020 May;72(5):909-923

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Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis.

Lu XY, Shi XJ, Hu A, Wang JQ, Ding Y, Jiang W, Sun M, Zhao X, Luo J, Qi W, Song BL
Nature 2020 Dec;588(7838):479-484