Antibody data
- Antibody Data
- Antigen structure
- References [115]
- Comments [0]
- Validations [0]
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- Product number
- 66406-1-Ig - Provider product page

- Provider
- Proteintech Group
- Product name
- CD80/B7-1 antibody
- Antibody type
- Monoclonal
- Description
- CD80/B7-1 antibody (Cat. #66406-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, pig and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Porcine
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 1E2F10
- Vial size
- 20ul, 150ul
Submitted references CD146(+) pericyte-like lung cancer brain metastatic stem cells promote tumor angiogenesis through dual regulatory effects on the VEGF/VEGFR axis.
A Rapid and High-Recovery Extracellular Vesicle (EVs) Isolation Technique from Blood Samples.
Breaking the immunosuppressive barrier: an armored CAR-M biotechnology with the original M1 phenotype dominance rescues antitumor immunity.
Dehydroandrographolide succinate alleviates ulcerative colitis via regulating RAB9A/NF-κB axis-mediated macrophage polarization and remodeling the gut microbiota.
Neuropeptide SP protects against colitis and linked anxiety-like behavior through the putative roles of gut microbiota and metabolite inositol.
A Fibrous Dressing Integrating Advanced Nanomicro Hybrid Structure with Effective Drug Delivery for Accelerated Wound Healing.
Caveolin-2 Knockdown Alleviated Sepsis-induced Acute Lung Injury Via Promoting Macrophage M2 Polarization and Inhibiting Apoptosis by Hippo Signaling Pathway.
ICAM2 loss drives 5-fluorouracil resistance via TGF-β/Smad/SP1/PTN-dependent apoptosis evasion and macrophage remodeling in gastric cancer.
Extracellular vesicles from TNF-α and TGF-β1-treated ADSCs promote tissue-engineered cartilage regeneration by modulating macrophages via the miR-378a-3p/SIRPα axis.
Conjugated polymer intrachain donor-acceptor reconfiguration-tailored off-on NIR-II photoacoustic probes with ultralow background for high-fidelity imaging of immunotherapy-associated macrophage reprogramming.
Fmoc-DDT@Fos hydrogel mitigates temporomandibular joint osteoarthritis through regulating macrophage reprogramming and ferroptosis.
Histochemical characterization of muscularis macrophage loss and disruption of a miR-93-5p-AHNAK neuro-immune axis in Hirschsprung's disease.
Ultrasound-Targeted Nanobubbles Codelivering NKP-1339 and miR-142-5p for Synergistic Mitochondrial Immunogenic Cell Death and PD-L1 Inhibition in Cancer Therapy.
Tumor-associated macrophages drive heterogenetic CD10(High) cancer stem cells to implement tumor-associated neutrophils reprogramming in oral squamous cell carcinoma.
Hyperuricemia in ob/ob mice relates to hepatocellular pyruvate metabolism/ xanthine oxidase axis.
Lung Tissue Extracellular Vesicles-Mediated Delivery of miR-128-3p as a Novel Mechanism of Acute Lung Inflammation.
Semaphorin 6D Alleviates Osteoarthritis by Inhibiting NLRP3 Inflammasome Activation and Endoplasmic Reticulum Stress.
Recombinant SADS-CoV as a vector for porcine epidemic diarrhea vaccine development.
Low Indoleamine 2,3-Dioxygenase 1 Expression Enhances Dendritic Cells Response to Tumor Cells Against Hepatocellular Carcinoma.
Echinocystic acid in Momordica charantia L. exosome-like nanovesicles attenuates dengue virus-induced vascular leakage associated inflammatory mediators through macrophage metabolic reprogramming and HIF-1α/p300-CBP interaction.
Extracellular vesicles derived from irradiated oral squamous cell carcinoma cells inhibits M2 macrophage polarization by the miR-198-5p/MYD88 axis.
Combining transcriptomics and network pharmacology to reveal the mechanisms of QuZhuoHuaYu decoction ameliorating gouty arthritis.
Dual molecularly imprinted nanocomposite with transferrin mediated glioma targeting and cholesterol exhaustion for synergistic cuproptosis/immune checkpoint blockade/immunogenic cell death.
SAMHD1 deficiency disrupts macrophage autophagy-lysosomal homeostasis and promotes inflammation via the mTOR-MITF-CTSD axis in ulcerative colitis.
POSTN-Mediated Interplay of M1 Polarized Macrophage with Tendon-Derived Stem Cells to Drive Traumatic Heterotopic Ossification Formation through PTK7/ATK Signaling?
Sinomenine alleviates gouty inflammation by inhibiting macrophage M1 polarization and neutrophil extracellular trap formation.
Procyanidin B2 alleviates LPS-induced acute lung injury by regulating M1 macrophage polarization and inhibiting pyroptosis via the NF-κB/JAK2/STAT1 signaling pathway.
Preclinical Fluorescence-Guided Imaging Leveraging Surrounding Sentinel Tumor Microenvironment Identifies High-Risk Premalignant Pancreatic Lesions.
SGMS2+ macrophages enhance NR4A3hi NK cell infiltration to improve prognosis and PD-1 treatment efficacy in hepatocellular carcinoma.
Antibacterial hyaluronic acid hydrogel with sustained release of larazotide as effective colitis treatment.
Tumor microenvironment-associated oxidative stress impairs SIRT1 secretion to suppress anti-tumor immune response.
Tumor-derived exosomal CCT6A serves as a matchmaker introducing chemokines to tumor-associated macrophages in pancreatic ductal adenocarcinoma.
Baicalin mitigates alcoholic-associated liver disease via SOCS1-driven reprogramming of macrophages.
Dual-modality immune nano-activator harnessing Mn(2)⁺ and quercetin to potentiate the cGAS-STING pathway for advanced cancer metalloimmunotherapy.
Multi-omics analysis revealed the novel role of NQO1 in microenvironment, prognosis and immunotherapy of hepatocellular carcinoma.
Identification of biomarkers associated with macrophage polarization in diabetic cardiomyopathy based on bioinformatics and machine learning approaches.
Green synthesis of silver nanoparticles using Fructus Aurantii-loaded Citrus pectin hydrogel for accelerated healing of MRSA-infected diabetic wounds.
Pitavastatin-loaded procyanidins self-assembled nanoparticles alleviate advanced atherosclerosis via modulating macrophage efferocytosis and cholesterol efflux.
ADRB2 inhibition suppresses cancer immune evasion by regulating tumor SOX10-PD-L1 axis and T cell function.
PDGFC secreted by cancer-associated fibroblasts promotes epithelial-mesenchymal transition and immunosuppression in lung adenocarcinoma.
The RNF8/OPTN/KDM6A axis controls macrophage polarization to maintain testicular microenvironment homeostasis.
Biomimetic Nanoparticles Simultaneously Targeting Modulation of Lipid Metabolism and Phenotype of Macrophages for Programmed Atherosclerosis Management.
Efferocytosis by Macrophages Attenuates Inflammatory Responses Following Ultraviolet B-Induced Apoptosis in Corneal Stromal Cells.
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Macrophage metabolic reprogramming ameliorates diabetes-induced microvascular dysfunction.
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Botulinum toxin type A inhibits M1 macrophage polarization by deactivation of JAK2/STAT1 and IκB/NFκB pathway and contributes to scar alleviation in aseptic skin wound healing.
Podocyte SIRPα reduction aggravates lupus nephritis via promoting T cell inflammatory responses.
Co-targeting CD47 and VEGF elicited potent anti-tumor effects in gastric cancer.
TPX2 influences the regulation of macrophage polarization via the NF-κB pathway in lung adenocarcinoma.
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Corosolic acid attenuates platelet-derived growth factor signaling in macrophages and smooth muscle cells of pulmonary arterial hypertension.
Myeloid-derived growth factor ameliorates dextran sodium sulfate-induced colitis by regulating macrophage polarization.
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Blockade of C5a receptor unleashes tumor-associated macrophage antitumor response and enhances CXCL9-dependent CD8(+) T cell activity.
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Overexpression of the β-Subunit of Acid Ceramidase in the Epidermis of Mice Provokes Atopic Dermatitis-like Skin Symptoms.
Neutrophil peptide 1 accelerates the clearance of degenerative axons during Wallerian degeneration by activating macrophages after peripheral nerve crush injury.
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Transcriptome sequencing reveals novel biomarkers and immune cell infiltration in esophageal tumorigenesis.
Activation of GABA receptor attenuates intestinal inflammation by modulating enteric glial cells function through inhibiting NF-κB pathway.
In vivo transfection of cytokine genes into tumor cells using a synthetic vehicle promotes antitumor immune responses in a visceral tumor model.
The involvement of Th1 cell differentiation in the anti-tumor effect of purified polysaccharide from Sanghuangporus vaninii in colorectal cancer via multi-omics analysis.
CTLA4 depletes T cell endogenous and trogocytosed B7 ligands via cis-endocytosis.
Macrophages and derived-TNF-α promote lipopolysaccharide-induced upregulation of endogenous β-glucuronidase in the epithelial cells of the bile duct: A possible facilitator of hepatolithiasis formation.
Five EMT-related genes signature predicts overall survival and immune environment in microsatellite instability-high gastric cancer.
Special issue "The advance of solid tumor research in China": Multi-omics analysis based on 1311 clear cell renal cell carcinoma samples identifies a glycolysis signature associated with prognosis and treatment response.
T cell-mediated targeted delivery of tadalafil regulates immunosuppression and polyamine metabolism to overcome immune checkpoint blockade resistance in hepatocellular carcinoma.
Converting bacteria into autologous tumor vaccine via surface biomineralization of calcium carbonate for enhanced immunotherapy.
TM9SF4 Is a Crucial Regulator of Inflammation and ER Stress in Inflammatory Bowel Disease.
Effect of Platycodon grandiflorus Polysaccharide on M1 Polarization Induced by Autophagy Degradation of SOCS1/2 Proteins in 3D4/21 Cells.
N-acetylcysteine attenuates atherosclerosis progression in aging LDL receptor deficient mice with preserved M2 macrophages and increased CD146.
Surface Coating of Pulmonary siRNA Delivery Vectors Enabling Mucus Penetration, Cell Targeting, and Intracellular Radical Scavenging for Enhanced Acute Lung Injury Therapy.
Effect of B7-H4 downregulation induced by Toxoplasma gondii infection on dysfunction of decidual macrophages contributes to adverse pregnancy outcomes.
ILT4 inhibition prevents TAM- and dysfunctional T cell-mediated immunosuppression and enhances the efficacy of anti-PD-L1 therapy in NSCLC with EGFR activation.
Injectable shear-thinning polylysine hydrogels for localized immunotherapy of gastric cancer through repolarization of tumor-associated macrophages.
TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca(2+)/CaMKII/Nrf2 signaling pathway.
Comprehensive analysis of prognostic immune-related genes and drug sensitivity in cervical cancer.
Mutual antagonism between indoleamine 2,3-dioxygenase 1 and nuclear factor E2-related factor 2 regulates the maturation status of DCs in liver fibrosis.
The Overexpression of CD80 and ISG15 Are Associated with the Progression and Metastasis of Breast Cancer by a Meta-Analysis Integrating Three Microarray Datasets.
A significant role of transcription factors E2F in inflammation and tumorigenesis of nasopharyngeal carcinoma.
CCL8 enhances sensitivity of cutaneous squamous cell carcinoma to photodynamic therapy by recruiting M1 macrophages.
The LncRNA MALAT1 regulates CD80 transcription via the NF-κB signaling pathway in the A549 cell line.
Knockdown of LncRNA MALAT1 contributes to cell apoptosis via regulating NF-κB/CD80 axis in neonatal respiratory distress syndrome.
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Dehydroandrographolide succinate alleviates ulcerative colitis via regulating RAB9A/NF-κB axis-mediated macrophage polarization and remodeling the gut microbiota.
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Caveolin-2 Knockdown Alleviated Sepsis-induced Acute Lung Injury Via Promoting Macrophage M2 Polarization and Inhibiting Apoptosis by Hippo Signaling Pathway.
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ICAM2 loss drives 5-fluorouracil resistance via TGF-β/Smad/SP1/PTN-dependent apoptosis evasion and macrophage remodeling in gastric cancer.
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Extracellular vesicles from TNF-α and TGF-β1-treated ADSCs promote tissue-engineered cartilage regeneration by modulating macrophages via the miR-378a-3p/SIRPα axis.
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Conjugated polymer intrachain donor-acceptor reconfiguration-tailored off-on NIR-II photoacoustic probes with ultralow background for high-fidelity imaging of immunotherapy-associated macrophage reprogramming.
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Fmoc-DDT@Fos hydrogel mitigates temporomandibular joint osteoarthritis through regulating macrophage reprogramming and ferroptosis.
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Tumor-associated macrophages drive heterogenetic CD10(High) cancer stem cells to implement tumor-associated neutrophils reprogramming in oral squamous cell carcinoma.
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International journal of biological sciences 2025;21(3):1110-1126
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Hyperuricemia in ob/ob mice relates to hepatocellular pyruvate metabolism/ xanthine oxidase axis.
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Semaphorin 6D Alleviates Osteoarthritis by Inhibiting NLRP3 Inflammasome Activation and Endoplasmic Reticulum Stress.
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Frontiers in immunology 2025;16:1633661
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Low Indoleamine 2,3-Dioxygenase 1 Expression Enhances Dendritic Cells Response to Tumor Cells Against Hepatocellular Carcinoma.
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Journal of hepatocellular carcinoma 2025;12:2149-2167
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Echinocystic acid in Momordica charantia L. exosome-like nanovesicles attenuates dengue virus-induced vascular leakage associated inflammatory mediators through macrophage metabolic reprogramming and HIF-1α/p300-CBP interaction.
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Extracellular vesicles derived from irradiated oral squamous cell carcinoma cells inhibits M2 macrophage polarization by the miR-198-5p/MYD88 axis.
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Dual molecularly imprinted nanocomposite with transferrin mediated glioma targeting and cholesterol exhaustion for synergistic cuproptosis/immune checkpoint blockade/immunogenic cell death.
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SAMHD1 deficiency disrupts macrophage autophagy-lysosomal homeostasis and promotes inflammation via the mTOR-MITF-CTSD axis in ulcerative colitis.
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POSTN-Mediated Interplay of M1 Polarized Macrophage with Tendon-Derived Stem Cells to Drive Traumatic Heterotopic Ossification Formation through PTK7/ATK Signaling?
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Sinomenine alleviates gouty inflammation by inhibiting macrophage M1 polarization and neutrophil extracellular trap formation.
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Procyanidin B2 alleviates LPS-induced acute lung injury by regulating M1 macrophage polarization and inhibiting pyroptosis via the NF-κB/JAK2/STAT1 signaling pathway.
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Journal of translational medicine 2025 Nov 28;24(1):13
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Journal of controlled release : official journal of the Controlled Release Society 2025 Nov 10;387:114205
Tumor microenvironment-associated oxidative stress impairs SIRT1 secretion to suppress anti-tumor immune response.
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Tumor-derived exosomal CCT6A serves as a matchmaker introducing chemokines to tumor-associated macrophages in pancreatic ductal adenocarcinoma.
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Baicalin mitigates alcoholic-associated liver disease via SOCS1-driven reprogramming of macrophages.
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Chinese medicine 2025 May 13;20(1):63
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Dual-modality immune nano-activator harnessing Mn(2)⁺ and quercetin to potentiate the cGAS-STING pathway for advanced cancer metalloimmunotherapy.
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Journal of nanobiotechnology 2025 Mar 25;23(1):248
Multi-omics analysis revealed the novel role of NQO1 in microenvironment, prognosis and immunotherapy of hepatocellular carcinoma.
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Scientific reports 2025 Mar 12;15(1):8591
Scientific reports 2025 Mar 12;15(1):8591
Identification of biomarkers associated with macrophage polarization in diabetic cardiomyopathy based on bioinformatics and machine learning approaches.
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Life sciences 2025 Mar 1;364:123443
Life sciences 2025 Mar 1;364:123443
Green synthesis of silver nanoparticles using Fructus Aurantii-loaded Citrus pectin hydrogel for accelerated healing of MRSA-infected diabetic wounds.
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International journal of biological macromolecules 2025 Jun;315(Pt 1):144222
International journal of biological macromolecules 2025 Jun;315(Pt 1):144222
Pitavastatin-loaded procyanidins self-assembled nanoparticles alleviate advanced atherosclerosis via modulating macrophage efferocytosis and cholesterol efflux.
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Acta pharmaceutica Sinica. B 2025 Jun;15(6):3305-3320
Acta pharmaceutica Sinica. B 2025 Jun;15(6):3305-3320
ADRB2 inhibition suppresses cancer immune evasion by regulating tumor SOX10-PD-L1 axis and T cell function.
Zhang Y, Yu F, Ouyang J, Liu P, Dai Y, Wang Y, Yi H, Wang S, Liu D, Song K, Pei W, Hong Z, Zhang W, Huang W, Zhou G, Cao S, McLeod H, Peng C, Chen L, He Y
Journal for immunotherapy of cancer 2025 Jun 12;13(6)
Journal for immunotherapy of cancer 2025 Jun 12;13(6)
PDGFC secreted by cancer-associated fibroblasts promotes epithelial-mesenchymal transition and immunosuppression in lung adenocarcinoma.
Cui M, Ding X, Jiang Y, Zhang L, Cao W, Wang Y, Sheng Z, Sun W, Guo A, Gu L, Zhang X, Duan W, Shi L, Zhang B
Acta biochimica et biophysica Sinica 2025 Jun 11;57(10):1625-1635
Acta biochimica et biophysica Sinica 2025 Jun 11;57(10):1625-1635
The RNF8/OPTN/KDM6A axis controls macrophage polarization to maintain testicular microenvironment homeostasis.
Guo Y, Xia P, Tian Y, Fu D, Hu X, Xie K, Dong W, Zhang W, Liu D, Shen R, Wang D
Cell death discovery 2025 Jul 24;11(1):339
Cell death discovery 2025 Jul 24;11(1):339
Biomimetic Nanoparticles Simultaneously Targeting Modulation of Lipid Metabolism and Phenotype of Macrophages for Programmed Atherosclerosis Management.
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ACS nano 2025 Jul 22;19(28):25628-25644
ACS nano 2025 Jul 22;19(28):25628-25644
Efferocytosis by Macrophages Attenuates Inflammatory Responses Following Ultraviolet B-Induced Apoptosis in Corneal Stromal Cells.
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Investigative ophthalmology & visual science 2025 Jul 1;66(9):49
A Zinc-Citrate Metal-Organic Framework-Based Adaptable Hydrogen Sulfide Delivery System for Regulating Neuroregeneration Microenvironment in Spinal Cord Injury.
Yao Y, Dong X, Pang Z, Shao J, He Z, Liu K, Hou P, Hu F, Liu W, Huo Y, Wang H, Dai H, Zhang X
ACS nano 2025 Jul 1;19(25):22798-22819
ACS nano 2025 Jul 1;19(25):22798-22819
Adipose-derived stem cells inhibit dendritic cell migration by secreting tumor necrosis factor-α-stimulated gene 6 to improve the allogeneic skin transplantation survival rate in mice.
Hu J, Peng W, Nurzat Y, Zhang Q, Lin Z, Xie J, Xu M, Ji H, Liang G, Zhang Z, Liao W, Zhang X
Cell transplantation 2025 Jan-Dec;34:9636897251376125
Cell transplantation 2025 Jan-Dec;34:9636897251376125
Mitochondrial transfer of drug-loaded artificial mitochondria for enhanced anti-Glioma therapy through synergistic apoptosis/ferroptosis/immunogenic cell death.
Song M, Yuan J, Zhang G, Sun M, Zhang Y, Su X, Lv R, Zhao Y, Shi Y, Zhao L
Acta biomaterialia 2025 Jan 24;193:514-530
Acta biomaterialia 2025 Jan 24;193:514-530
N 6-Methyladenosine Demethylase FTO Controls Macrophage Homeostasis in Diabetic Vasculopathy.
Feng S, Zhang Q, Liu Q, Huang C, Zhang H, Wang F, Zhu Y, Jian Q, Chen X, Jiang Q, Yan B
Diabetes 2025 Jan 1;74(1):82-95
Diabetes 2025 Jan 1;74(1):82-95
Macrophage metabolic reprogramming ameliorates diabetes-induced microvascular dysfunction.
Zhang QY, Zhang HY, Feng SG, Yao MD, Ding JJ, Li XM, Ye R, Liu Q, Yao J, Yan B
Redox biology 2025 Feb;79:103449
Redox biology 2025 Feb;79:103449
An OMV-Based Nanovaccine as Antigen Presentation Signal Enhancer for Cancer Immunotherapy.
Lu Y, Ma N, Cheng K, Liu G, Liang J, Xu C, Li D, Cao C, Gao X, Chen L, Wang X, Wang Y, Zhao X, Jiang K
Advanced materials (Deerfield Beach, Fla.) 2025 Feb;37(8):e2413392
Advanced materials (Deerfield Beach, Fla.) 2025 Feb;37(8):e2413392
Corydalis decumbens and tetrahydropalmatrubin inhibit macrophages inflammation to relieve rheumatoid arthritis by targeting Fosl2.
Gao P, Yuan S, Wang Y, Wang Y, Li X, Liu T, Zheng Y, Wang J, Liu D, Xu L, Jiang Y, Zeng K, Tu P
Journal of ethnopharmacology 2025 Feb 11;341:119348
Journal of ethnopharmacology 2025 Feb 11;341:119348
CCL8 suppresses ovarian cancer progression via M1 macrophage polarization and NF-κB-mediated apoptosis.
Fang J, Zhao X, Wang J, Yang Y, Xiao Y
Scientific reports 2025 Dec 17;16(1):2960
Scientific reports 2025 Dec 17;16(1):2960
Electroacupuncture Improves Microglial Polarization Induced-Inflammation by Regulating the TGF-β/Smad-3 Signaling Pathway in Ischemic Stroke Mice.
Yang G, Zhang L, Yuan Y, Mazhar M, Zhang D, Liu Y, Chen G, Fan X
CNS neuroscience & therapeutics 2025 Aug;31(8):e70567
CNS neuroscience & therapeutics 2025 Aug;31(8):e70567
Tailoring Long-Lived Charge Separation Enables Efficient Light-to-Heat Conversion for Efficient Cancer Therapy.
Liu W, Hu Z, Zhang J, Zhao J, Wang S, Xu X, Xu G, Genin GM, Shao Y, Hu L, Xu F, Jin G, Tang BZ
ACS nano 2025 Aug 19;19(32):29503-29516
ACS nano 2025 Aug 19;19(32):29503-29516
Bimetallic peroxide-based nanotherapeutics for immunometabolic intervention and induction of immunogenic cell death to augment cancer immunotherapy.
Han M, Zhou S, Liao Z, Zishan C, Yi X, Wu C, Zhang D, He Y, Leong KW, Zhong Y
Biomaterials 2025 Apr;315:122934
Biomaterials 2025 Apr;315:122934
Dendritic Cell Derived-Extracellular Vesicles Engineered to Express Interleukin-12 and Anti-CTLA-4 on Their Surface for Combinational Cancer Immunotherapy.
Chen J, Tan Q, Yang Z, Chen W, Zhou E, Li M, Deng J, Wu Y, Liu J, Xu J, Guo M, Jin Y
Journal of extracellular vesicles 2025 Apr;14(4):e70068
Journal of extracellular vesicles 2025 Apr;14(4):e70068
CpG-Based Nanovaccines Enhance Ovarian Cancer Immune Response by Gbp2-Mediated Remodeling of Tumor-Associated Macrophages.
Xiong J, Huang J, Xu H, Wu Q, Zhao J, Chen Y, Fan G, Guan H, Xiao R, He Z, Wu S, Ouyang W, Wang S, Zhang L, Xia P, Zhang W, Wu M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2412881
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2412881
Melatonin modulates neuroinflammatory response and microglial activation in mice exposed to dim blue light at night.
Song C, Suo Z, Wang Z, Cao J, Dong Y, Chen Y
Frontiers in pharmacology 2024;15:1416350
Frontiers in pharmacology 2024;15:1416350
STAC3 as a poor prognostic biomarker in renal clear cell carcinoma: relationship with immune infiltration.
Zhang Y, Li J, Feng L, Cheng Y, Shi L, Yang Q, Wang Z, Yi X, Zhong G, Sun X, Cheng Z, Guo M
American journal of cancer research 2024;14(7):3294-3316
American journal of cancer research 2024;14(7):3294-3316
CA19-9-related macrophage polarization drives poor prognosis in HCC after immune checkpoint inhibitor treatment.
Du T, Zou J, Yang Y, Xie H, Pang H, Zhuang W, Wang S, Wei G
Frontiers in oncology 2024;14:1528138
Frontiers in oncology 2024;14:1528138
Enhanced enrichment of extracellular vesicles for laboratory and clinical research from drop-sized blood samples.
Guerrero-Alba A, Bansal S, Sankpal AN, Mitra G, Rahman M, Ravichandran R, Poulson C, Fleming TP, Smith MA, Bremner RM, Mohanakumar T, Sankpal NV
Frontiers in molecular biosciences 2024;11:1365783
Frontiers in molecular biosciences 2024;11:1365783
The association of appendectomy with prognosis and tumor-associated macrophages in patients with colorectal cancer.
Liu G, Hu C, Wei J, Li Q, Zhang J, Zhang Z, Qu P, Cao Z, Wang R, Ji G, She J, Shi F
iScience 2024 Sep 20;27(9):110578
iScience 2024 Sep 20;27(9):110578
Study on the mechanism of macrophages activated by phosphoesterified rehmanniae polysaccharide on human gastric cancer cells.
Liu X, Yang F, Ren P, Lv W, Chen B, Niu B, Ren Y, Wang L, Sun M, Zuo Z, Li J, Geng A
International journal of biological macromolecules 2024 Oct;277(Pt 1):133952
International journal of biological macromolecules 2024 Oct;277(Pt 1):133952
Vimentin, inversely correlating with infiltration of CD8 + T lymphocytes, promotes nuclear translocation of PD-L1 in esophageal squamous cell carcinoma.
Liang Y, He S, Liu Q, Liu T, Tan Y, Peng T, Huang C, Lu X, Zheng S
Biochimica et biophysica acta. Molecular cell research 2024 Oct;1871(7):119781
Biochimica et biophysica acta. Molecular cell research 2024 Oct;1871(7):119781
miRNA375-3p/rapamycin mediates the mTOR pathway by decreasing PS1, enhances microglial cell activity to regulate autophagy in Alzheimer's disease.
Wang Y, Xiao Z, Yin H, Ren Z, Ma X, Wang Y, Zhang Y, Fu X, Zhang F, Zeng L
Heliyon 2024 Oct 15;10(19):e37589
Heliyon 2024 Oct 15;10(19):e37589
Hesperetin alleviates aflatoxin B1 induced liver toxicity in mice: Modulating lipid peroxidation and ferritin autophagy.
Song C, Wang Z, Cao J, Dong Y, Chen Y
Ecotoxicology and environmental safety 2024 Oct 1;284:116854
Ecotoxicology and environmental safety 2024 Oct 1;284:116854
Tumor associated antigens combined with carbon dots for inducing durable antitumor immunity.
Liu H, Zhang T, Zheng M, Xie Z
Journal of colloid and interface science 2024 Nov;673:594-606
Journal of colloid and interface science 2024 Nov;673:594-606
Interleukin-33 Deficiency Protects the Skin From Ulcer Formation in an Ischemia-Reperfusion-Induced Decubitus Mouse Model.
Jin M, Komine M, Tsuda H, Sashikawa-Kimura M, Nakae S, Motegi SI, Ohtsuki M
Experimental dermatology 2024 Nov;33(11):e70014
Experimental dermatology 2024 Nov;33(11):e70014
Distinct activation of M1 and M2 macrophages in the primary pterygium lymphangiogenesis.
Lee SJ, Koh A, Lee SH, Kim KW
Experimental eye research 2024 Nov;248:110108
Experimental eye research 2024 Nov;248:110108
Dual-targeted halofuginone hydrobromide nanocomplexes for promotion of macrophage repolarization and apoptosis of rheumatoid arthritis fibroblast-like synoviocytes in adjuvant-induced arthritis in rats.
Zhu J, Lin Y, Li G, He Y, Su Z, Tang Y, Zhang Y, Xu Q, Yao Z, Zhou H, Liu B, Cai X
Journal of pharmaceutical analysis 2024 Nov;14(11):100981
Journal of pharmaceutical analysis 2024 Nov;14(11):100981
Neutrophil extracellular traps promote M1 macrophage polarization in gouty inflammation via targeting hexokinase-2.
Tan H, Zhang S, Zhang Z, Zhang J, Wang Z, Liao J, Qiu X, Jia E
Free radical biology & medicine 2024 Nov 1;224:540-553
Free radical biology & medicine 2024 Nov 1;224:540-553
Botulinum toxin type A inhibits M1 macrophage polarization by deactivation of JAK2/STAT1 and IκB/NFκB pathway and contributes to scar alleviation in aseptic skin wound healing.
Zou YP, Shan XF, Qiu JX, Wang LN, Xiang RL, Cai ZG
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116468
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116468
Podocyte SIRPα reduction aggravates lupus nephritis via promoting T cell inflammatory responses.
Qian B, Lu R, Mao S, Chen Y, Yang M, Zhang W, Zhang M, Zhu D, Liu Z, Zen K, Li L
Cell reports 2024 May 28;43(5):114249
Cell reports 2024 May 28;43(5):114249
Co-targeting CD47 and VEGF elicited potent anti-tumor effects in gastric cancer.
Zhang K, Xu Y, Chang X, Xu C, Xue W, Ding D, Nie M, Cai H, Xu J, Zhan L, Han J, Cai T, Ju D, Feng L, Zhang X, Yin K
Cancer immunology, immunotherapy : CII 2024 Mar 27;73(4):75
Cancer immunology, immunotherapy : CII 2024 Mar 27;73(4):75
TPX2 influences the regulation of macrophage polarization via the NF-κB pathway in lung adenocarcinoma.
Wang L, Zhang H, Li Y, Li L
Life sciences 2024 Mar 1;340:122437
Life sciences 2024 Mar 1;340:122437
Prednisone combined with Dihydroartemisinin attenuates systemic lupus erythematosus by regulating M1/M2 balance through the MAPK signaling pathway.
Chen Y, Tao T, Liang Z, Chen X, Xu Y, Zhang T, Zhou D
Molecular immunology 2024 Jun;170:144-155
Molecular immunology 2024 Jun;170:144-155
Distinctive multicellular immunosuppressive hubs confer different intervention strategies for left- and right-sided colon cancers.
Liu B, Li S, Cheng Y, Song P, Xu M, Li Z, Shao W, Xin J, Fu Z, Gu D, Du M, Zhang Z, Wang M
Cell reports. Medicine 2024 Jun 18;5(6):101589
Cell reports. Medicine 2024 Jun 18;5(6):101589
Corosolic acid attenuates platelet-derived growth factor signaling in macrophages and smooth muscle cells of pulmonary arterial hypertension.
Yamamura A, Fujiwara M, Kawade A, Amano T, Hossain A, Nayeem MJ, Kondo R, Suzuki Y, Inoue Y, Hayashi H, Suzuki S, Sato M, Yamamura H
European journal of pharmacology 2024 Jun 15;973:176564
European journal of pharmacology 2024 Jun 15;973:176564
Myeloid-derived growth factor ameliorates dextran sodium sulfate-induced colitis by regulating macrophage polarization.
Yang Y, Zhao C, Yang Z, Du C, Chang Z, Wen X, Zhang X, Liu Y, Hu L, Gao Z
Journal of molecular medicine (Berlin, Germany) 2024 Jul;102(7):875-886
Journal of molecular medicine (Berlin, Germany) 2024 Jul;102(7):875-886
Noninvasive Transdermal Administration of mRNA Vaccines Encoding Multivalent Neoantigens Effectively Inhibits Melanoma Growth.
Hou Y, Wang Z, Chen Z, Shuai L, Pei Y, Sun B, Jiang Y, Wang H
ACS biomaterials science & engineering 2024 Jul 8;10(7):4587-4600
ACS biomaterials science & engineering 2024 Jul 8;10(7):4587-4600
HMGB1/TREM2 positive feedback loop drives the development of radioresistance and immune escape of glioblastoma by regulating TLR4/Akt signaling.
Qiu H, Shao Z, Wen X, Qu D, Liu Z, Chen Z, Zhang X, Ding X, Zhang L
Journal of translational medicine 2024 Jul 29;22(1):688
Journal of translational medicine 2024 Jul 29;22(1):688
Virus-Mimetic Extracellular-Vesicle Vaccine Boosts Systemic and Mucosal Immunity via Immune Recruitment.
Li J, Xing H, Meng F, Liu T, Hong X, Han X, Dong Y, Li M, Wang Z, Zhang S, Cui C, Zheng A
ACS nano 2024 Jul 16;
ACS nano 2024 Jul 16;
Comprehensive molecular characterization of long-term glioblastoma survivors.
Xu H, Chen X, Sun Y, Hu X, Zhang X, Wang Y, Tang Q, Zhu Q, Song K, Chen H, Sheng X, Yao Y, Zhuang D, Chen L, Mao Y, Qin Z
Cancer letters 2024 Jul 1;593:216938
Cancer letters 2024 Jul 1;593:216938
Hinokitiol as a modulator of TLR4 signaling and apoptotic pathways in atopic dermatitis.
Tai LR, Chiang YF, Huang KC, Chen HY, Ali M, Hsia SM
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jan;170:116026
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jan;170:116026
NIR-Actuated Targeted Janus Nanomotors Remodel Immunosuppressive Tumor Microenvironment for Augmented Cancer Immunotherapy.
Zhou X, Ma E, Zhang Y, Xing Y, Xu W, Chen L, Zhou H, Zhang X, Jiang C, Xu K, Wang H, Zheng S
Advanced healthcare materials 2024 Jan;13(2):e2302272
Advanced healthcare materials 2024 Jan;13(2):e2302272
Metal-polyphenol networks-modified tantalum plate for craniomaxillofacial reconstruction.
Wei Z, Shen Z, Deng H, Kuang T, Wang J, Gu Z
Scientific reports 2024 Jan 10;14(1):1023
Scientific reports 2024 Jan 10;14(1):1023
Blockade of C5a receptor unleashes tumor-associated macrophage antitumor response and enhances CXCL9-dependent CD8(+) T cell activity.
Luan X, Lei T, Fang J, Liu X, Fu H, Li Y, Chu W, Jiang P, Tong C, Qi H, Fu Y
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Feb 7;32(2):469-489
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Feb 7;32(2):469-489
Engineered Magneto-Piezoelectric Nanoparticles-Enhanced Scaffolds Disrupt Biofilms and Activate Oxidative Phosphorylation in Icam1(+) Macrophages for Infectious Bone Defect Regeneration.
Wu H, Chen C, Li J, Yu D, Wu X, Huang H, Tang Z, Wu Q, Yan S, Wang N, Wang M, Wei F, Yu Y, Wang D, Shi M, Yue X, Cao P, Zheng Z, Li X, Guo B, Shi L, Guo Z
ACS nano 2024 Dec 31;18(52):35575-35594
ACS nano 2024 Dec 31;18(52):35575-35594
Overexpression of the β-Subunit of Acid Ceramidase in the Epidermis of Mice Provokes Atopic Dermatitis-like Skin Symptoms.
Sashikawa-Kimura M, Takada M, Hossain MR, Tsuda H, Xie X, Komine M, Ohtsuki M, Imokawa G
International journal of molecular sciences 2024 Aug 10;25(16)
International journal of molecular sciences 2024 Aug 10;25(16)
Neutrophil peptide 1 accelerates the clearance of degenerative axons during Wallerian degeneration by activating macrophages after peripheral nerve crush injury.
Kou Y, Yuan Y, Li Q, Xie W, Xu H, Han N
Neural regeneration research 2024 Aug 1;19(8):1822-1827
Neural regeneration research 2024 Aug 1;19(8):1822-1827
Near Infrared Responsive Gold Nanorods Attenuate Osteoarthritis Progression by Targeting TRPV1.
Li W, Lv Z, Wang P, Xie Y, Sun W, Guo H, Jin X, Liu Y, Jiang R, Fei Y, Tan G, Jiang H, Wang X, Liu Z, Wang Z, Xu N, Gong W, Wu R, Shi D
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(16):e2307683
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(16):e2307683
Transcriptome sequencing reveals novel biomarkers and immune cell infiltration in esophageal tumorigenesis.
Sun JR, Chen DM, Huang R, Wang RT, Jia LQ
World journal of gastrointestinal oncology 2024 Apr 15;16(4):1500-1513
World journal of gastrointestinal oncology 2024 Apr 15;16(4):1500-1513
Activation of GABA receptor attenuates intestinal inflammation by modulating enteric glial cells function through inhibiting NF-κB pathway.
Deng Z, Li D, Yan X, Lan J, Han D, Fan K, Chang J, Ma Y
Life sciences 2023 Sep 15;329:121984
Life sciences 2023 Sep 15;329:121984
In vivo transfection of cytokine genes into tumor cells using a synthetic vehicle promotes antitumor immune responses in a visceral tumor model.
Watanabe S, Takagi A, Yuba E, Kojima C, Dei N, Matsumoto A, Tanikawa J, Kawamura T, De Silva NH, Izawa T, Akazawa T, Kanegi R, Hatoya S, Inaba T, Sugiura K
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Nov;37(11):e23228
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Nov;37(11):e23228
The involvement of Th1 cell differentiation in the anti-tumor effect of purified polysaccharide from Sanghuangporus vaninii in colorectal cancer via multi-omics analysis.
Qu Y, Yang H, Li S, Li L, Li Y, Wang D
International journal of biological macromolecules 2023 May 15;237:123927
International journal of biological macromolecules 2023 May 15;237:123927
CTLA4 depletes T cell endogenous and trogocytosed B7 ligands via cis-endocytosis.
Xu X, Dennett P, Zhang J, Sherrard A, Zhao Y, Masubuchi T, Bui JD, Chen X, Hui E
The Journal of experimental medicine 2023 Jul 3;220(7)
The Journal of experimental medicine 2023 Jul 3;220(7)
Macrophages and derived-TNF-α promote lipopolysaccharide-induced upregulation of endogenous β-glucuronidase in the epithelial cells of the bile duct: A possible facilitator of hepatolithiasis formation.
Yang Y, Wang Y, Wang C, Wu S, Yao D
Clinics and research in hepatology and gastroenterology 2023 Jan;47(1):102062
Clinics and research in hepatology and gastroenterology 2023 Jan;47(1):102062
Five EMT-related genes signature predicts overall survival and immune environment in microsatellite instability-high gastric cancer.
Zhang M, Cao C, Li X, Gu Q, Xu Y, Zhu Z, Xu D, Wei S, Chen H, Yang Y, Gao H, Yu L, Li J
Cancer medicine 2023 Jan;12(2):2075-2088
Cancer medicine 2023 Jan;12(2):2075-2088
Special issue "The advance of solid tumor research in China": Multi-omics analysis based on 1311 clear cell renal cell carcinoma samples identifies a glycolysis signature associated with prognosis and treatment response.
Tian X, Wang Y, Xu W, Tang H, Zhu S, Anwaier A, Liu W, Wang W, Zhu W, Su J, Qu Y, Zhang H, Ye D
International journal of cancer 2023 Jan 1;152(1):66-78
International journal of cancer 2023 Jan 1;152(1):66-78
T cell-mediated targeted delivery of tadalafil regulates immunosuppression and polyamine metabolism to overcome immune checkpoint blockade resistance in hepatocellular carcinoma.
Wang X, Zhang Q, Zhou J, Xiao Z, Liu J, Deng S, Hong X, Huang W, Cai M, Guo Y, Huang J, Wang Y, Lin L, Zhu K
Journal for immunotherapy of cancer 2023 Feb;11(2)
Journal for immunotherapy of cancer 2023 Feb;11(2)
Converting bacteria into autologous tumor vaccine via surface biomineralization of calcium carbonate for enhanced immunotherapy.
Guo L, Ding J, Zhou W
Acta pharmaceutica Sinica. B 2023 Dec;13(12):5074-5090
Acta pharmaceutica Sinica. B 2023 Dec;13(12):5074-5090
TM9SF4 Is a Crucial Regulator of Inflammation and ER Stress in Inflammatory Bowel Disease.
Xie M, Mak JWY, Yu H, Cheng CTY, Chan HCH, Chan TT, Lau LHS, Wong MTL, Ko WH, Jiang L, Yao X
Cellular and molecular gastroenterology and hepatology 2022;14(2):245-270
Cellular and molecular gastroenterology and hepatology 2022;14(2):245-270
Effect of Platycodon grandiflorus Polysaccharide on M1 Polarization Induced by Autophagy Degradation of SOCS1/2 Proteins in 3D4/21 Cells.
Li L, Chen X, Lv M, Cheng Z, Liu F, Wang Y, Zhou A, Liu J, Zhao X
Frontiers in immunology 2022;13:934084
Frontiers in immunology 2022;13:934084
N-acetylcysteine attenuates atherosclerosis progression in aging LDL receptor deficient mice with preserved M2 macrophages and increased CD146.
Zhu Q, Xiao Y, Jiang M, Liu X, Cui Y, Hao H, Flaker GC, Liu Q, Zhou S, Liu Z
Atherosclerosis 2022 Sep;357:41-50
Atherosclerosis 2022 Sep;357:41-50
Surface Coating of Pulmonary siRNA Delivery Vectors Enabling Mucus Penetration, Cell Targeting, and Intracellular Radical Scavenging for Enhanced Acute Lung Injury Therapy.
Zhu J, Guo M, Cui Y, Meng Y, Ding J, Zeng W, Zhou W
ACS applied materials & interfaces 2022 Feb 2;14(4):5090-5100
ACS applied materials & interfaces 2022 Feb 2;14(4):5090-5100
Effect of B7-H4 downregulation induced by Toxoplasma gondii infection on dysfunction of decidual macrophages contributes to adverse pregnancy outcomes.
Cui L, Wang Y, Ren L, Li Z, Jiang Y, Wang C, Liu X, Ren Y, Hu X
Parasites & vectors 2022 Dec 13;15(1):464
Parasites & vectors 2022 Dec 13;15(1):464
ILT4 inhibition prevents TAM- and dysfunctional T cell-mediated immunosuppression and enhances the efficacy of anti-PD-L1 therapy in NSCLC with EGFR activation.
Chen X, Gao A, Zhang F, Yang Z, Wang S, Fang Y, Li J, Wang J, Shi W, Wang L, Zheng Y, Sun Y
Theranostics 2021;11(7):3392-3416
Theranostics 2021;11(7):3392-3416
Injectable shear-thinning polylysine hydrogels for localized immunotherapy of gastric cancer through repolarization of tumor-associated macrophages.
Yang Y, Yang Y, Chen M, Chen J, Wang J, Ma Y, Qian H
Biomaterials science 2021 Sep 28;9(19):6597-6608
Biomaterials science 2021 Sep 28;9(19):6597-6608
TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca(2+)/CaMKII/Nrf2 signaling pathway.
Lv Z, Xu X, Sun Z, Yang YX, Guo H, Li J, Sun K, Wu R, Xu J, Jiang Q, Ikegawa S, Shi D
Cell death & disease 2021 May 18;12(6):504
Cell death & disease 2021 May 18;12(6):504
Comprehensive analysis of prognostic immune-related genes and drug sensitivity in cervical cancer.
Pi YN, Guo JN, Lou G, Cui BB
Cancer cell international 2021 Dec 1;21(1):639
Cancer cell international 2021 Dec 1;21(1):639
Mutual antagonism between indoleamine 2,3-dioxygenase 1 and nuclear factor E2-related factor 2 regulates the maturation status of DCs in liver fibrosis.
Mo C, Xie S, Zhong W, Zeng T, Huang S, Lai Y, Deng G, Zhou C, Yan W, Chen Y, Huang S, Gao L, Lv Z
Free radical biology & medicine 2020 Nov 20;160:178-190
Free radical biology & medicine 2020 Nov 20;160:178-190
The Overexpression of CD80 and ISG15 Are Associated with the Progression and Metastasis of Breast Cancer by a Meta-Analysis Integrating Three Microarray Datasets.
Li Y, Bai W, Zhang L
Pathology oncology research : POR 2020 Jan;26(1):443-452
Pathology oncology research : POR 2020 Jan;26(1):443-452
A significant role of transcription factors E2F in inflammation and tumorigenesis of nasopharyngeal carcinoma.
Liu P, Zhang X, Li Z, Wei L, Peng Q, Liu C, Wu Y, Yan Q, Ma J
Biochemical and biophysical research communications 2020 Apr 16;524(4):816-824
Biochemical and biophysical research communications 2020 Apr 16;524(4):816-824
CCL8 enhances sensitivity of cutaneous squamous cell carcinoma to photodynamic therapy by recruiting M1 macrophages.
Ji J, Wang P, Zhou Q, Zhu L, Zhang H, Zhang Y, Zheng Z, Bhatta AK, Zhang G, Wang X
Photodiagnosis and photodynamic therapy 2019 Jun;26:235-243
Photodiagnosis and photodynamic therapy 2019 Jun;26:235-243
The LncRNA MALAT1 regulates CD80 transcription via the NF-κB signaling pathway in the A549 cell line.
Juan C, Mao Y, Wang Q, Cao Q, Chen Y, Zhou G
Biochemical and biophysical research communications 2018 Sep 10;503(3):1674-1681
Biochemical and biophysical research communications 2018 Sep 10;503(3):1674-1681
Knockdown of LncRNA MALAT1 contributes to cell apoptosis via regulating NF-κB/CD80 axis in neonatal respiratory distress syndrome.
Juan C, Wang Q, Mao Y, Cao Q, Li S, Qiao C, Zhang D, Zhou G
The international journal of biochemistry & cell biology 2018 Nov;104:138-148
The international journal of biochemistry & cell biology 2018 Nov;104:138-148
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