28397-1-AP

antibody from Proteintech Group

Targeting: TBK1 NAK

Provider product page for 28397-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [43]
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Product number: 28397-1-AP - Provider product page
Provider: Proteintech Group
Product name: TBK1 antibody
Antibody type: Polyclonal
Description: TBK1 antibody (Cat. #28397-1-AP) is a rabbit polyclonal antibody that shows reactivity with Human and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

TBK1 protein structure - 28397-1-AP shown in red.

Submitted references mtDNA-cGAS-STING axis-dependent NLRP3 inflammasome activation contributes to postoperative cognitive dysfunction induced by sevoflurane in mice.

Yang NS, Zhong WJ, Sha HX, Zhang CY, Jin L, Duan JX, Xiong JB, You ZJ, Zhou Y, Guan CX
International journal of biological sciences 2024;20(5):1927-1946

Salvianolic acid A prevents UV-induced skin damage by inhibiting the cGAS-STING pathway.

Zuo Z, He S, Qiu Y, Guo R, He Y, Jiao C, Xia Y, Liu W, Luan C, Guo W
International immunopharmacology 2024 May 10;132:111971

CKLF induces microglial activation via triggering defective mitophagy and mitochondrial dysfunction.

Wang H, Ye J, Peng Y, Ma W, Chen H, Sun H, Feng Z, He W, Li G, Chu S, Zhang Z, Chen N
Autophagy 2024 Mar;20(3):590-613

Non-canonical isoforms of the mRNA polyadenylation factor WDR33 regulate STING-mediated immune responses.

Liu L, Manley JL
Cell reports 2024 Mar 26;43(3):113886

IDI1 inhibits the cGAS-Sting signaling pathway in hepatocellular carcinoma.

Fu L, Ding H, Bai Y, Cheng L, Hu S, Guo Q
Heliyon 2024 Mar 15;10(5):e27205

Pseudorabies virus manipulates mitochondrial tryptophanyl-tRNA synthetase 2 for viral replication.

Li XQ, Cai MP, Wang MY, Shi BW, Yang GY, Wang J, Chu BB, Ming SL
Virologica Sinica 2024 Jun;39(3):403-413

Flavonoid extracted from Epimedium attenuate cGAS-STING-mediated diseases by targeting the formation of functional STING signalosome.

Wang Y, Xu G, Wen J, Zhao X, Zhao H, Lv G, Xu Y, Xiu Y, Li J, Chen S, Yao Q, Chen Y, Ma L, Xiao X, Cao J, Bai Z
Immunology 2024 Jun;172(2):295-312

Compound Danshen Dripping Pill effectively alleviates cGAS-STING-triggered diseases by disrupting STING-TBK1 interaction.

Shi W, Xu G, Gao Y, Yang H, Liu T, Zhao J, Li H, Wei Z, Hou X, Chen Y, Wen J, Li C, Zhao J, Zhang P, Wang Z, Xiao X, Bai Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155404

Comparative proteomics analysis of kidney in chicken infected by infectious bronchitis virus.

Huang M, Zheng X, Zhang Y, Wang R, Wei X
Poultry science 2024 Jan;103(1):103259

Histone H1.2 Inhibited EMCV Replication through Enhancing MDA5-Mediated IFN-β Signaling Pathway.

Song Y, Li H, Lian R, Dou X, Li S, Xie J, Li X, Feng R, Li Z
Viruses 2024 Jan 24;16(2)

PPM1G regulates hepatic ischemia/reperfusion injury through STING-mediated inflammatory pathways in macrophages.

Peng D, Huang Z, Yang H, Luo Y, Wu Z
Immunity, inflammation and disease 2024 Feb;12(2):e1189

Nitisinone attenuates cartilage degeneration and subchondral osteoclastogenesis in osteoarthritis and concomitantly inhibits the cGAS/STING/NF-κB pathway.

Yang T, Ma H, Lai H, Lu Y, Ni K, Hu X, Zhou Y, Zhou Z, Li W, Fang J, Zhang Y, Chen Z, He D
European journal of pharmacology 2024 Feb 15;965:176326

mtDNA regulates cGAS-STING signaling pathway in adenomyosis.

Wang K, Wen Y, Fu X, Wei S, Liu S, Chen M
Free radical biology & medicine 2024 Apr;216:80-88

African swine fever virus pB318L, a trans-geranylgeranyl-diphosphate synthase, negatively regulates cGAS-STING and IFNAR-JAK-STAT signaling pathways.

Liu X, Chen H, Ye G, Liu H, Feng C, Chen W, Hu L, Zhou Q, Zhang Z, Li J, Zhang X, He X, Guan Y, Wu Z, Zhao D, Bu Z, Weng C, Huang L
PLoS pathogens 2024 Apr;20(4):e1012136

Inhibition of cGAS aggravated the host inflammatory response to Aspergillus fumigatus.

Peng M, Li X, Zhang X, Peng L
Experimental lung research 2023;49(1):86-100

Porcine reproductive and respiratory syndrome virus-mediated lactate facilitates virus replication by targeting MAVS.

Zhang L, Liu X, Mao J, Sun Y, Gao Y, Bai J, Jiang P
Veterinary microbiology 2023 Sep;284:109846

African Swine Fever Virus H240R Protein Inhibits the Production of Type I Interferon through Disrupting the Oligomerization of STING.

Ye G, Liu H, Liu X, Chen W, Li J, Zhao D, Wang G, Feng C, Zhang Z, Zhou Q, Zheng J, Bu Z, Weng C, Huang L
Journal of virology 2023 Sep 28;97(9):e0057723

The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation.

Ouyang W, Wang S, Yan D, Wu J, Zhang Y, Li W, Hu J, Liu Z
Signal transduction and targeted therapy 2023 Sep 21;8(1):371

STING/ACSL4 axis-dependent ferroptosis and inflammation promote hypertension-associated chronic kidney disease.

Gao L, Zhang J, Yang T, Jiang L, Liu X, Wang S, Wang X, Huang Y, Wang H, Zhang M, Gong T, Ma L, Li C, He C, Meng XM, Wu Y
Molecular therapy : the journal of the American Society of Gene Therapy 2023 Oct 4;31(10):3084-3103

Naringenin Improves Innate Immune Suppression after PRRSV Infection by Reactivating the RIG-I-MAVS Signaling Pathway, Promoting the Production of IFN-I.

Yu J, Shi H, Song K, Yang Y, Li X, Peng L, Fu B, Yi P
Viruses 2023 Oct 29;15(11)

Flavonoids derived from licorice suppress LPS-induced acute lung injury in mice by inhibiting the cGAS-STING signaling pathway.

Wen J, Qin S, Li Y, Zhang P, Zhan X, Fang M, Shi C, Mu W, Kan W, Zhao J, Hui S, Hou M, Li H, Xiao X, Xu G, Bai Z
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 May;175:113732

SMYD2 inhibition-mediated hypomethylation of Ku70 contributes to impaired nonhomologous end joining repair and antitumor immunity.

Tang M, Chen G, Tu B, Hu Z, Huang Y, DuFort CC, Wan X, Mao Z, Liu Y, Zhu WG, Lu W
Science advances 2023 Jun 16;9(24):eade6624

mascRNA alleviates STING-TBK1 signaling-mediated immune response through promoting ubiquitination of STING.

Hu Y, Li X, Wang D, Mao X
Molecular immunology 2023 Feb;154:45-53

Apoptotic tumor cell-derived microparticles loading Napabucasin inhibit CSCs and synergistic immune therapy.

Jing B, Guo F, An R, Gao Y, Li Y, Xie Y, Wang J, Chen Y, Li H, Gao T, Jin Q, Zhang L, Xie M
Journal of nanobiotechnology 2023 Feb 2;21(1):37

Inhibition of ACLY overcomes cancer immunotherapy resistance via polyunsaturated fatty acids peroxidation and cGAS-STING activation.

Xiang W, Lv H, Xing F, Sun X, Ma Y, Wu L, Lv G, Zong Q, Wang L, Wu Z, Feng Q, Yang W, Wang H
Science advances 2023 Dec 8;9(49):eadi2465

Glabridin improves autoimmune disease in Trex1-deficient mice by reducing type I interferon production.

Wen J, Mu W, Li H, Yan Y, Zhan X, Luo W, Wang Z, Kan W, Zhao J, Hui S, He P, Qin S, Xu Y, Zhang P, Xiao X, Xu G, Bai Z
Molecular medicine (Cambridge, Mass.) 2023 Dec 8;29(1):167

A HER2-targeting antibody-MMAE conjugate RC48 sensitizes immunotherapy in HER2-positive colon cancer by triggering the cGAS-STING pathway.

Wu X, Xu L, Li X, Zhou Y, Han X, Zhang W, Wang W, Guo W, Liu W, Xu Q, Gu Y
Cell death & disease 2023 Aug 24;14(8):550

A role of STING signaling in obesity-induced lung inflammation.

Qi Y, Wu Z, Chen D, Zhu L, Yang Y
International journal of obesity (2005) 2023 Apr;47(4):325-334

Predicting the Immune Microenvironment and Prognosis with a NETosis-Related lncRNA Signature in Head and Neck Squamous Cell Carcinoma.

He X, Xiao Y, Liu S, Deng R, Li Z, Zhu X
BioMed research international 2022;2022:3191474

Identification of highly specific antibodies for Serine/threonine-protein kinase TBK1 for use in immunoblot, immunoprecipitation and immunofluorescence.

Alshafie W, Fotouhi M, Shlaifer I, Ayoubi R, Edwards AM, Durcan TM, McPherson PS, Laflamme C
F1000Research 2022;11:977

Circulating cell-free mtDNA release is associated with the activation of cGAS-STING pathway and inflammation in mitochondrial diseases.

Zhao X, Yu M, Zhao Y, Zheng Y, Meng L, Du K, Xie Z, Lv H, Zhang W, Liu J, Wang Q, Yuan Y, Wang Z, Deng J
Journal of neurology 2022 Sep;269(9):4985-4996

Activation of cGAS-STING pathway - A possible cause of myofiber atrophy/necrosis in dermatomyositis and immune-mediated necrotizing myopathy.

Zhou M, Cheng X, Zhu W, Jiang J, Zhu S, Wu X, Liu M, Fang Q
Journal of clinical laboratory analysis 2022 Oct;36(10):e24631

STING pathway contributes to the prognosis of hepatocellular carcinoma and identification of prognostic gene signatures correlated to tumor microenvironment.

Pu Z, Liu J, Liu Z, Peng F, Zhu Y, Wang X, He J, Yi P, Hu X, Fan X, Chen J
Cancer cell international 2022 Oct 12;22(1):314

eIF4A3 Promotes RNA Viruses' Replication by Inhibiting Innate Immune Responses.

Gao Q, Jiang M, Zhao Y, Li G, Yang C, Ren C, Jin M, Chen H, Zhou H
Journal of virology 2022 Nov 23;96(22):e0151322

IKKε protects against starvation-induced NLRP3 inflammasome and pyroptosis in H9c2 cells by alleviating mitochondrial injury.

Chen G, Xu Y, Fan R, Liu Y, Yao Y, Jiang H, Wu Q, Li L, Chen W, Chen X
Biochemical and biophysical research communications 2022 Jan 22;589:267-274

QKI deficiency in macrophages protects mice against JEV infection by regulating cell migration and antiviral response.

Deng L, Wang W, Bian P, Wu M, Wang L, Lei Y, Lu Z, Zhai D
Molecular immunology 2022 Aug;148:34-44

TANK-Binding Kinase 1 (TBK1) Serves as a Potential Target for Hepatocellular Carcinoma by Enhancing Tumor Immune Infiltration.

Jiang Y, Chen S, Li Q, Liang J, Lin W, Li J, Liu Z, Wen M, Cao M, Hong J
Frontiers in immunology 2021;12:612139

PARP inhibitor niraparib as a radiosensitizer promotes antitumor immunity of radiotherapy in EGFR-mutated non-small cell lung cancer.

Zhang N, Gao Y, Zeng Z, Luo Y, Jiang X, Zhang J, Li J, Zhang J, Gong Y, Xie C
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2021 Sep;23(9):1827-1837

A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response.

Zhao Y, Sui L, Wu P, Wang W, Wang Z, Yu Y, Hou Z, Tan G, Liu Q, Wang G
Signal transduction and targeted therapy 2021 Sep 1;6(1):331

The cGAS-STING signaling pathway contributes to the inflammatory response and autophagy in Aspergillus fumigatus keratitis.

Han F, Guo H, Wang L, Zhang Y, Sun L, Dai C, Wu X
Experimental eye research 2021 Jan;202:108366

African swine fever virus MGF505-11R inhibits type I interferon production by negatively regulating the cGAS-STING-mediated signaling pathway.

Yang K, Huang Q, Wang R, Zeng Y, Cheng M, Xue Y, Shi C, Ye L, Yang W, Jiang Y, Wang J, Huang H, Cao X, Yang G, Wang C
Veterinary microbiology 2021 Dec;263:109265

Stimulator of IFN genes mediates neuroinflammatory injury by suppressing AMPK signal in experimental subarachnoid hemorrhage.

Peng Y, Zhuang J, Ying G, Zeng H, Zhou H, Cao Y, Chen H, Xu C, Fu X, Xu H, Li J, Cao S, Chen J, Gu C, Yan F, Chen G
Journal of neuroinflammation 2020 May 25;17(1):165

Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response.

Li M, Shu HB
Protein & cell 2020 Aug;11(8):584-599

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