Explore
Validate
Learn
Western blotAntibody data
- Antibody Data
- Antigen structure
- References [124]
- Comments [0]
- Validations [0]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 28397-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- TBK1 antibody
- Antibody type
- Polyclonal
- Description
- TBK1 antibody (Cat. #28397-1-AP) is a rabbit polyclonal antibody that shows reactivity with Human and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Targeting the LHX1-LDB1 Complex Restores STING-dependent Senescence Surveillance and Inhibits Head and Neck Cancer Progression.
The prognostic significance of JAML and its role in remodeling the immune microenvironment via the cGAS-STING pathway in endometrial cancer.
Spike RBD drives sustained Parkinson's disease progression via microglia-neuron crosstalk-mediated RTP801 upregulation.
Betrixaban activates cGAS and ERVs to promote dual nucleic-sensing antiviral immunity.
Minimolide F alleviates inflammatory diseases by specifically targeting STING and blocking IRF3 recruitment.
Fibroblast growth factor-inducible 14 accelerates pulmonary fibrosis by inducing fibroblast senescence in mice.
STING Drives Psoriatic Inflammation by Promoting Neutrophil Recruitment and Facilitating NETosis.
E3 ubiquitin ligase Stub1 enhances viral replication by promoting TBK1 degradation through molecular chaperone-mediated autophagy.
PTPN2 alleviates psoriasis by targeting the STING-STAT3 axis and restoring autophagy: in vitro and in vivo evidence.
O-GlcNAcylation of YAP1 promotes lung transplant ischemia-reperfusion injury via binding to HIF1α transcription factor and activating autophagy and mitophagy.
cGAS-STING signaling pathway promotes ischemic kidney injury by regulating HK3-mediated lipid accumulation.
Systemic LINE-1 RNA in Plasma Extracellular Vesicles Drives Neuroinflammation and Cognitive Dysfunction via cGAS-STING Pathway in Aging.
SARS-CoV-2 spike protein induces depressive-like behaviors by disrupting astrocytic Cx43-mediated gap junction intercellular communication.
Nanoparticle-Modified Nanofibers Induce Ferroptosis and Stimulate Antitumor Immunity for Melanoma Therapy.
Zinc finger protein ZNF33B facilitates Japanese encephalitis virus replication by regulating m(6)A modification on Ifih1 and Irf3 transcripts to antagonize antiviral response.
Cucurbitacin B Inhibits Hepatocellular Carcinoma by Inducing Ferroptosis and Activating the cGAS-STING Pathway.
Trillin attenuates liver ischemia-reperfusion injury by inhibiting autophagy through regulation of the cGAS-STING pathway.
Cardiomyocyte-Derived USP20 Attenuates Diabetic Cardiomyopathy by Facilitating the Degradation of STING and Mitigating STING-Mediated Inflammation.
Single-cell sequencing-guided design of synergistic chemo-immunotherapy nanodrugs for cGAS-STING activation in prostate cancer therapy.
Mitochondrial IRF3 drives pulmonary fibrosis by impairing mitophagy and triggering ferroptosis.
Identification of Pinostilbene as a natural STING agonist that triggers FTH1 degradation via K48-ubiquitination to induce ferroptosis in non-small cell lung cancer.
EMCV Non-Structural Protein 2C Antagonizes cGAS-STING-Mediated Type I Interferon Signaling via Promoting K48-Linked Polyubiquitination and Degradation of STING.
YWHAZ downregulated innate immune responses to RNA viruses by inhibiting the IRF3 signaling pathway.
PIM1 Inhibition Alleviates Aspergillus fumigatus Keratitis by Regulating DDX41-Mediated STING Signaling Pathway.
Yinhua Pinggan Granules alleviate lung and intestinal damage in influenza virus-infected mice by modulating gut microbiota and its metabolites to activate the GPR43-MAVS-IRF3-IFN-β pathway.
Betrixaban is a broad anti-virus inhibitor by activating innate immunity.
Extrachromosomal circular DNA drives ferroptosis and immunity in trophoblasts via the STING pathway in preeclampsia.
Fufang epimedium formula alleviates acute liver injury through dual modulation of PI3K/AKT/Bcl-2 anti-apoptotic signaling pathway and cGAS-STING-IRF3 anti-inflammatory signaling pathway.
African swine fever virus pMGF505-9R enhances RIG-I-like receptor signaling by promoting RING finger protein 125 autoubiquitination.
GALNT6 dual regulates innate immunity STING signaling and PD-L1 expression to promote immune evasion in pancreatic ductal adenocarcinoma.
Pseudorabies virus DNA polymerase processivity factor pUL42 inhibits type I IFN production by negatively regulating cGAS-STING signaling pathway.
Photosynthetic Plant-Derived Nanovesicles Precisely Amplify Photodynamic Effect by Light-Activated Oxygen Generation for Enhanced Cancer Photoimmunotherapy.
Improvement of the stability of ginsenoside Rg5 and its pharmacological efficacy in nonalcoholic steatohepatitis.
PNMA4 enhances anti-RNA virus immunity by promoting RIG-I signaling pathway.
AGR2-mediated cell-cell communication controls the antiviral immune response by promoting the thiol oxidation of TRAF3.
Cholesterol biosynthesis induced by radiotherapy inhibits cGAS-STING activation and contributes to colorectal cancer treatment resistance.
Targeting and reprogramming microglial phagocytosis of neutrophils by ginsenoside Rg1 nanovesicles promotes stroke recovery.
Astragalin alleviates lipopolysaccharide-induced depressive-like behavior in mice by preserving blood-brain barrier integrity and suppressing neuroinflammation.
Chemotherapy boosts anti-angiogenic and anti-PD-1 combination therapy through activation of cCAS-STING pathway in colon cancer.
Elevation of ISG15 promotes diabetic kidney disease by modulating renal tubular epithelial cell pyroptosis.
Network Pharmacology, Molecular Dynamics Simulation, and Biological Validation Insights into the Potential of Ligustri Lucidi Fructus for Diabetic Nephropathy.
ENPP1 governs the metabolic regulation of effector T cells in autoimmunity by detecting cytosolic mitochondrial DNA.
Therapeutic effects of Saussurea graminea Dunn and its active compounds in sepsis-associated liver injury: Transcriptomics, metabolomics and experimental validation.
Phosphorylation of syntenin-1 by TBK1 promotes proliferation and migration of non-small cell lung cancer cells.
Inhibiting UGCG prevents PRV infection by decreasing lysosome-associated autophage.
The antiviral activity of myricetin against pseudorabies virus through regulation of the type I interferon signaling pathway.
MVK, induced by Kras, represses cGAS-Sting signalling in lung adenocarcinoma.
MYO1F positions cGAS on the plasma membrane to ensure full and functional signaling.
Inhibition of LRRK2 Ameliorates Aspergillus fumigatus Keratitis by Regulating STING Signaling Pathways.
β-Hydroxybutyrate-induced mitochondrial DNA (mtDNA) release mediated innate inflammatory response in bovine mammary epithelial cells by inhibiting autophagy.
Bavachinin exerts anti-tumor effects by activating TLR4/STING axis-dependent PANoptosis and synergistically enhances chemosensitivity in endometrial cancer.
HSYA targets the ZBP1-166R site to inhibit MAVS signaling: A potential therapeutic strategy for cerebral ischemia-reperfusion injury.
KAT2A affects the inflammatory progression of lupus nephritis through multilevel regulation of cGAS.
Linker histone H1.3 promotes IFN-β production targeting MDA5 signaling to inhibit EMCV infection.
miR-30a enhanced RIG-I-mediated type I interferon antiviral response by targeting USP14.
Porcine epidemic diarrhea virus nsp14 inhibited IFN-Ⅰ production by targeting RIG-I for degradation.
Accumulation of Damaging Lipids in the Arf1-Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia.
Comprehensive PTM profiling with SCASP-PTM uncovers mechanisms of p62 degradation and ALDOA-mediated tumor progression.
An Immune Subtype Classification System Enables the Development of Strategies to Predict and Enhance Immunotherapy Responses in Colorectal Cancer.
mtDNA-cGAS-STING axis-dependent NLRP3 inflammasome activation contributes to postoperative cognitive dysfunction induced by sevoflurane in mice.
Neutrophil extracellular traps trigger alveolar epithelial cell necroptosis through the cGAS-STING pathway during acute lung injury in mice.
Activation of cGAS confers PARP inhibitor resistance in ovarian cancer via the TBK1-IRF3 axis.
African swine fever virus MGF505-6R attenuates type I interferon production by targeting STING for degradation.
NSDHL promotes the degradation of sting in cholangiocarcinoma.
Targeting PRMT3 impairs methylation and oligomerization of HSP60 to boost anti-tumor immunity by activating cGAS/STING signaling.
Glycyrrhetinic acid blocks SARS-CoV-2 infection by activating the cGAS-STING signalling pathway.
STING Agonist Delivered by Neutrophil Membrane-Coated Gold Nanoparticles Exerts Synergistic Tumor Inhibition with Radiotherapy.
Homoplantaginin alleviates high glucose-induced vascular endothelial senescence by inhibiting mtDNA-cGAS-STING pathway via blunting DRP1-mitochondrial fission-VDAC1 axis.
A TBK1-independent primordial function of STING in lysosomal biogenesis.
The PRMT6/STAT1/ACSL1 axis promotes ferroptosis in diabetic nephropathy.
TRIM32 inhibits Venezuelan equine encephalitis virus infection by targeting a late step in viral entry.
Angiopoietin 1 Relieves Osteolysis by Promoting Macrophage Mitophagy Through the TBK1-SQSTM1 Pathway to Inhibit AIM2 Inflammasome-Mediated Pyroptosis.
Cadmium exposure triggers alveolar epithelial cell pyroptosis by inducing mitochondrial oxidative stress and activating the cGAS-STING pathway.
Inactivation of Myostatin Delays Senescence via TREX1-SASP in Bovine Skeletal Muscle Cells.
Salvianolic acid A prevents UV-induced skin damage by inhibiting the cGAS-STING pathway.
CKLF induces microglial activation via triggering defective mitophagy and mitochondrial dysfunction.
Non-canonical isoforms of the mRNA polyadenylation factor WDR33 regulate STING-mediated immune responses.
IDI1 inhibits the cGAS-Sting signaling pathway in hepatocellular carcinoma.
Pseudorabies virus manipulates mitochondrial tryptophanyl-tRNA synthetase 2 for viral replication.
Flavonoid extracted from Epimedium attenuate cGAS-STING-mediated diseases by targeting the formation of functional STING signalosome.
Mammalian reovirus µ1 protein attenuates RIG-I and MDA5-mediated signaling transduction by blocking IRF3 phosphorylation and nuclear translocation.
Compound Danshen Dripping Pill effectively alleviates cGAS-STING-triggered diseases by disrupting STING-TBK1 interaction.
TRIM32 inhibits Venezuelan Equine Encephalitis Virus Infection by targeting a late step in viral entry.
TBK1 pharmacological inhibition mitigates osteoarthritis through attenuating inflammation and cellular senescence in chondrocytes.
MARCH1 negatively regulates TBK1-mTOR signaling pathway by ubiquitinating TBK1.
Comparative proteomics analysis of kidney in chicken infected by infectious bronchitis virus.
Histone H1.2 Inhibited EMCV Replication through Enhancing MDA5-Mediated IFN-β Signaling Pathway.
PPM1G regulates hepatic ischemia/reperfusion injury through STING-mediated inflammatory pathways in macrophages.
Nitisinone attenuates cartilage degeneration and subchondral osteoclastogenesis in osteoarthritis and concomitantly inhibits the cGAS/STING/NF-κB pathway.
Polydatin attenuates diabetic renal inflammatory fibrosis via the inhibition of STING pathway.
SARS-CoV-2 spike-induced syncytia are senescent and contribute to exacerbated heart failure.
STRAP upregulates antiviral innate immunity against PRV by targeting TBK1.
CDK4/6 Alters TBK1 Phosphorylation to Inhibit the STING Signaling Pathway in Prostate Cancer.
mtDNA regulates cGAS-STING signaling pathway in adenomyosis.
African swine fever virus pB318L, a trans-geranylgeranyl-diphosphate synthase, negatively regulates cGAS-STING and IFNAR-JAK-STAT signaling pathways.
Inhibition of cGAS aggravated the host inflammatory response to Aspergillus fumigatus.
Porcine reproductive and respiratory syndrome virus-mediated lactate facilitates virus replication by targeting MAVS.
African Swine Fever Virus H240R Protein Inhibits the Production of Type I Interferon through Disrupting the Oligomerization of STING.
The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation.
STING/ACSL4 axis-dependent ferroptosis and inflammation promote hypertension-associated chronic kidney disease.
Naringenin Improves Innate Immune Suppression after PRRSV Infection by Reactivating the RIG-I-MAVS Signaling Pathway, Promoting the Production of IFN-I.
Flavonoids derived from licorice suppress LPS-induced acute lung injury in mice by inhibiting the cGAS-STING signaling pathway.
SMYD2 inhibition-mediated hypomethylation of Ku70 contributes to impaired nonhomologous end joining repair and antitumor immunity.
mascRNA alleviates STING-TBK1 signaling-mediated immune response through promoting ubiquitination of STING.
Apoptotic tumor cell-derived microparticles loading Napabucasin inhibit CSCs and synergistic immune therapy.
Inhibition of ACLY overcomes cancer immunotherapy resistance via polyunsaturated fatty acids peroxidation and cGAS-STING activation.
Glabridin improves autoimmune disease in Trex1-deficient mice by reducing type I interferon production.
A HER2-targeting antibody-MMAE conjugate RC48 sensitizes immunotherapy in HER2-positive colon cancer by triggering the cGAS-STING pathway.
A role of STING signaling in obesity-induced lung inflammation.
Predicting the Immune Microenvironment and Prognosis with a NETosis-Related lncRNA Signature in Head and Neck Squamous Cell Carcinoma.
Identification of highly specific antibodies for Serine/threonine-protein kinase TBK1 for use in immunoblot, immunoprecipitation and immunofluorescence.
Circulating cell-free mtDNA release is associated with the activation of cGAS-STING pathway and inflammation in mitochondrial diseases.
Activation of cGAS-STING pathway - A possible cause of myofiber atrophy/necrosis in dermatomyositis and immune-mediated necrotizing myopathy.
STING pathway contributes to the prognosis of hepatocellular carcinoma and identification of prognostic gene signatures correlated to tumor microenvironment.
eIF4A3 Promotes RNA Viruses' Replication by Inhibiting Innate Immune Responses.
IKKε protects against starvation-induced NLRP3 inflammasome and pyroptosis in H9c2 cells by alleviating mitochondrial injury.
QKI deficiency in macrophages protects mice against JEV infection by regulating cell migration and antiviral response.
TANK-Binding Kinase 1 (TBK1) Serves as a Potential Target for Hepatocellular Carcinoma by Enhancing Tumor Immune Infiltration.
PARP inhibitor niraparib as a radiosensitizer promotes antitumor immunity of radiotherapy in EGFR-mutated non-small cell lung cancer.
A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response.
The cGAS-STING signaling pathway contributes to the inflammatory response and autophagy in Aspergillus fumigatus keratitis.
African swine fever virus MGF505-11R inhibits type I interferon production by negatively regulating the cGAS-STING-mediated signaling pathway.
Stimulator of IFN genes mediates neuroinflammatory injury by suppressing AMPK signal in experimental subarachnoid hemorrhage.
Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response.
Long M, Chen Y, Du R, Yang J, Wang J, Sun Y, Tian X, Wang S, Zhong Y, Liang W, Zhang J, Shang Z
International journal of biological sciences 2026;22(3):1186-1206
International journal of biological sciences 2026;22(3):1186-1206
The prognostic significance of JAML and its role in remodeling the immune microenvironment via the cGAS-STING pathway in endometrial cancer.
Tian C, Yao Y, Tu Y, Yu J, Gong C, Shi X, Yu H, Jiang P
Frontiers in immunology 2026;17:1738596
Frontiers in immunology 2026;17:1738596
Spike RBD drives sustained Parkinson's disease progression via microglia-neuron crosstalk-mediated RTP801 upregulation.
Wang SS, Yuan RL, Wang WF, Peng Y, Hu KC, He WB, Zhao YX, Yan X, Zhang Z, Chu SF, Chen NH
Journal of advanced research 2026 May;83:315-332
Journal of advanced research 2026 May;83:315-332
Betrixaban activates cGAS and ERVs to promote dual nucleic-sensing antiviral immunity.
Chen X, Zhao Y, Xie Y, Liu T, Wang H, Wang X, Guo X, You F
EMBO molecular medicine 2026 May;18(5):1563-1591
EMBO molecular medicine 2026 May;18(5):1563-1591
Minimolide F alleviates inflammatory diseases by specifically targeting STING and blocking IRF3 recruitment.
Wen J, Xu Y, Qin S, Guo Y, Wang X, Liu L, Lu Z, Yan Y, Zhan X, Zhao J, Xiao X, Bai Z
International immunopharmacology 2026 May 1;176:116468
International immunopharmacology 2026 May 1;176:116468
Fibroblast growth factor-inducible 14 accelerates pulmonary fibrosis by inducing fibroblast senescence in mice.
Guan XX, Zhong WJ, Tang WF, Liu YB, Chen MR, Li JL, Zhang CY, Zhou Y, Guan CX, Wu JN, Ma L, Duan JX
Cellular and molecular life sciences : CMLS 2026 Mar 6;83(1)
Cellular and molecular life sciences : CMLS 2026 Mar 6;83(1)
STING Drives Psoriatic Inflammation by Promoting Neutrophil Recruitment and Facilitating NETosis.
Luo H, Hu C, Tian T, Qian T, Jiang X, Dang Y, Chen B, Yang Z, Luo N, Zhang D, Hao F
Immunology 2026 Mar 3;
Immunology 2026 Mar 3;
E3 ubiquitin ligase Stub1 enhances viral replication by promoting TBK1 degradation through molecular chaperone-mediated autophagy.
Liu H, Yu J, Ye G, Gao J, Huang L, Zhang Z, Weng C
Cell death and differentiation 2026 Mar 25;
Cell death and differentiation 2026 Mar 25;
PTPN2 alleviates psoriasis by targeting the STING-STAT3 axis and restoring autophagy: in vitro and in vivo evidence.
Yang Y, Zhong Y, Liu F, Liu S, Chen Y
Immunobiology 2026 Mar 20;231(3):153174
Immunobiology 2026 Mar 20;231(3):153174
O-GlcNAcylation of YAP1 promotes lung transplant ischemia-reperfusion injury via binding to HIF1α transcription factor and activating autophagy and mitophagy.
Dai S, Wan X, Xia L, Xu L, Xie C, Wang G, Tang J
Cell death & disease 2026 Mar 15;17(1)
Cell death & disease 2026 Mar 15;17(1)
cGAS-STING signaling pathway promotes ischemic kidney injury by regulating HK3-mediated lipid accumulation.
Wang D, Zhou Z, Zhao Z, Liu M, Li Y, Mu L, Zhou H, Li X, Zhang F, Tian S, Zhou X, Shi Y
Free radical biology & medicine 2026 Jun;249:246-259
Free radical biology & medicine 2026 Jun;249:246-259
Systemic LINE-1 RNA in Plasma Extracellular Vesicles Drives Neuroinflammation and Cognitive Dysfunction via cGAS-STING Pathway in Aging.
Yu S, Cheng Q, Yu Q, Cui Z, Chen H, Wu S, Jin Y, Wang Y, Li M, Lu Z
Aging cell 2026 Jan;25(1):e70350
Aging cell 2026 Jan;25(1):e70350
SARS-CoV-2 spike protein induces depressive-like behaviors by disrupting astrocytic Cx43-mediated gap junction intercellular communication.
Yuan RL, Wang SS, Li PY, Ruan Y, He JQ, Zhou R, Wang WF, Jiang YT, Ye JR, Peng Y, He WB, Chu SF, Zhang Z, Chen NH
Brain, behavior, and immunity 2026 Jan;131:106176
Brain, behavior, and immunity 2026 Jan;131:106176
Nanoparticle-Modified Nanofibers Induce Ferroptosis and Stimulate Antitumor Immunity for Melanoma Therapy.
Li M, Li R, Xu B, Lian Y, Yang C, Li J, Liang J, Ding L, Zhang D, Guo J, Fu X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(1):e08753
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(1):e08753
Zinc finger protein ZNF33B facilitates Japanese encephalitis virus replication by regulating m(6)A modification on Ifih1 and Irf3 transcripts to antagonize antiviral response.
Du J, Li C, Zhang J, Luo J, Zhang H, Chen H, Li X, Qian P
Cell & bioscience 2026 Jan 4;16(1):13
Cell & bioscience 2026 Jan 4;16(1):13
Cucurbitacin B Inhibits Hepatocellular Carcinoma by Inducing Ferroptosis and Activating the cGAS-STING Pathway.
Zhang H, Chang A, Xu X, Peng H, Zhang K, Yang J, Li W, Wang X, Wang W, Yin X, Qu C, Dong X, Ni J
Current issues in molecular biology 2026 Jan 27;48(2)
Current issues in molecular biology 2026 Jan 27;48(2)
Trillin attenuates liver ischemia-reperfusion injury by inhibiting autophagy through regulation of the cGAS-STING pathway.
Wu T, Yu Q, Wang Y, Tang H, Guo W
International immunopharmacology 2026 Jan 1;168(Pt 2):115790
International immunopharmacology 2026 Jan 1;168(Pt 2):115790
Cardiomyocyte-Derived USP20 Attenuates Diabetic Cardiomyopathy by Facilitating the Degradation of STING and Mitigating STING-Mediated Inflammation.
Zhou Y, Ying M, Qi B, Chen Y, Lin W, Zhang C, Lin J, Zhang Y, Yang Z, Huang Z, Wu J, Cai X, Huang W, Huang Z, Cheng Z, Dai S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Feb 15;40(3):e71540
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Feb 15;40(3):e71540
Single-cell sequencing-guided design of synergistic chemo-immunotherapy nanodrugs for cGAS-STING activation in prostate cancer therapy.
Jiang Y, Zhang Y, Hou J, Liu H, Dai X, Hou Y
Journal of nanobiotechnology 2026 Feb 1;24(1)
Journal of nanobiotechnology 2026 Feb 1;24(1)
Mitochondrial IRF3 drives pulmonary fibrosis by impairing mitophagy and triggering ferroptosis.
Jiashu Z, Jingbao L, Hua F, Meiqi S, Jing L, Mengyao W, Wei Z
Cellular signalling 2026 Aug;144:112517
Cellular signalling 2026 Aug;144:112517
Identification of Pinostilbene as a natural STING agonist that triggers FTH1 degradation via K48-ubiquitination to induce ferroptosis in non-small cell lung cancer.
Song S, Hua S, Chen G, Yin X, Chen Z, Li C, Zhou D, Zhu B
Redox biology 2026 Apr;91:104099
Redox biology 2026 Apr;91:104099
EMCV Non-Structural Protein 2C Antagonizes cGAS-STING-Mediated Type I Interferon Signaling via Promoting K48-Linked Polyubiquitination and Degradation of STING.
Cheng R, Dong P, Xing W, Jin H, Ma T, Xie J, Wen Y, Su B, Li X, Feng R
Viruses 2026 Apr 5;18(4)
Viruses 2026 Apr 5;18(4)
YWHAZ downregulated innate immune responses to RNA viruses by inhibiting the IRF3 signaling pathway.
Li S, Han J, Wang H, Hou J, Wang L, Hou Z, Zhang Y, Dou X, Xie J, Li H, Li X, Feng R
mSphere 2026 Apr 28;11(4):e0003826
mSphere 2026 Apr 28;11(4):e0003826
PIM1 Inhibition Alleviates Aspergillus fumigatus Keratitis by Regulating DDX41-Mediated STING Signaling Pathway.
Han F, Wang L, Wu J, Ma H, Luo X, Li J
Investigative ophthalmology & visual science 2026 Apr 1;67(4):2
Investigative ophthalmology & visual science 2026 Apr 1;67(4):2
Yinhua Pinggan Granules alleviate lung and intestinal damage in influenza virus-infected mice by modulating gut microbiota and its metabolites to activate the GPR43-MAVS-IRF3-IFN-β pathway.
Zeng D, Zhou H, Wan H, Chen J
Frontiers in microbiology 2025;16:1532108
Frontiers in microbiology 2025;16:1532108
Betrixaban is a broad anti-virus inhibitor by activating innate immunity.
Hu S, Zhao Y, Chen X, Wang H, Hu W, Huang R, Yang J, Niu C, Guo X, You F
Frontiers in cellular and infection microbiology 2025;15:1603530
Frontiers in cellular and infection microbiology 2025;15:1603530
Extrachromosomal circular DNA drives ferroptosis and immunity in trophoblasts via the STING pathway in preeclampsia.
Wang X, Bian W, Huang M, Li T, Xiong H, Xiang S, Li H, Yang H, Yang H
Biochemical and biophysical research communications 2025 Sep 25;781:152522
Biochemical and biophysical research communications 2025 Sep 25;781:152522
Fufang epimedium formula alleviates acute liver injury through dual modulation of PI3K/AKT/Bcl-2 anti-apoptotic signaling pathway and cGAS-STING-IRF3 anti-inflammatory signaling pathway.
Feng Y, Yusufu R, Chen T, Guan Z, Zhang L, Li S, Luo M, Jiang H, Wei F
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120415
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120415
African swine fever virus pMGF505-9R enhances RIG-I-like receptor signaling by promoting RING finger protein 125 autoubiquitination.
Zhao J, Zhang X, Mou C, Shi K, Chen Z
The Journal of biological chemistry 2025 Oct;301(10):110669
The Journal of biological chemistry 2025 Oct;301(10):110669
GALNT6 dual regulates innate immunity STING signaling and PD-L1 expression to promote immune evasion in pancreatic ductal adenocarcinoma.
Chong S, Liu Y, Bian Z, Hu D, Guo S, Dong C, Zeng J, Fan S, Chen X
Cellular signalling 2025 Oct;134:111942
Cellular signalling 2025 Oct;134:111942
Pseudorabies virus DNA polymerase processivity factor pUL42 inhibits type I IFN production by negatively regulating cGAS-STING signaling pathway.
Ye G, Gao J, Cao H, Liu X, Liu H, Wang S, Liu Y, Han L, Zhou Q, Tang Y, Tian J, Huang L, Huang L, Zhang Z, Weng C
Journal of virology 2025 Oct 23;99(10):e0121825
Journal of virology 2025 Oct 23;99(10):e0121825
Photosynthetic Plant-Derived Nanovesicles Precisely Amplify Photodynamic Effect by Light-Activated Oxygen Generation for Enhanced Cancer Photoimmunotherapy.
Mei J, Pan W, Li B, Zhong M, Shi X, Cheng Y, Wu B, Xiu Q, Xue Y, Situ B, Zheng L
ACS nano 2025 Oct 14;19(40):35933-35950
ACS nano 2025 Oct 14;19(40):35933-35950
Improvement of the stability of ginsenoside Rg5 and its pharmacological efficacy in nonalcoholic steatohepatitis.
Ma J, Bai X, Duan Z, Fu R, Zeng W, Li Y, Guan Z, Zhu C
Life sciences 2025 Oct 1;378:123818
Life sciences 2025 Oct 1;378:123818
PNMA4 enhances anti-RNA virus immunity by promoting RIG-I signaling pathway.
Song H, Li ZW, Xie YT, Tang X, Hu YT, Tan Y, Huang Y, Cheng YL, Pei G, Kuang M
International immunopharmacology 2025 Nov 14;165:115446
International immunopharmacology 2025 Nov 14;165:115446
AGR2-mediated cell-cell communication controls the antiviral immune response by promoting the thiol oxidation of TRAF3.
Jia M, Chen X, Guo W, Ma D, Wang P, Niu H, Liu C, Lin X, Lu Q, Wang J, Zheng X, Sun Q, Gao C, Yuan H
Redox biology 2025 May;82:103581
Redox biology 2025 May;82:103581
Cholesterol biosynthesis induced by radiotherapy inhibits cGAS-STING activation and contributes to colorectal cancer treatment resistance.
Zhu L, Tang Z, Jiang W, Dong Y, Li X, Huang K, Wu T, Xu L, Guo W, Gu Y
Experimental & molecular medicine 2025 May;57(5):1089-1105
Experimental & molecular medicine 2025 May;57(5):1089-1105
Targeting and reprogramming microglial phagocytosis of neutrophils by ginsenoside Rg1 nanovesicles promotes stroke recovery.
Hu K, Ye J, Fan P, Zheng R, Wang S, Peng Y, Ruan Y, Yan X, Zhang Z, Chu S, Chen N
Bioactive materials 2025 May;47:181-197
Bioactive materials 2025 May;47:181-197
Astragalin alleviates lipopolysaccharide-induced depressive-like behavior in mice by preserving blood-brain barrier integrity and suppressing neuroinflammation.
Cao MM, Guo Z, Wang J, Ma HY, Qin XY, Hu Y, Lan R
Free radical biology & medicine 2025 May;232:340-352
Free radical biology & medicine 2025 May;232:340-352
Chemotherapy boosts anti-angiogenic and anti-PD-1 combination therapy through activation of cCAS-STING pathway in colon cancer.
Li X, Dong Y, Wang T, Huang K, Guo W, Xu L, Gu Y
International immunopharmacology 2025 Mar 6;149:114212
International immunopharmacology 2025 Mar 6;149:114212
Elevation of ISG15 promotes diabetic kidney disease by modulating renal tubular epithelial cell pyroptosis.
Huang L, Chen X, Shao Y, Deng S, Wang C, Chen J, Xie Y, Yuan S, Tang L
Clinical and translational medicine 2025 Jun;15(6):e70337
Clinical and translational medicine 2025 Jun;15(6):e70337
Network Pharmacology, Molecular Dynamics Simulation, and Biological Validation Insights into the Potential of Ligustri Lucidi Fructus for Diabetic Nephropathy.
Liu M, Gu Y, Yang Y, Zhang K, Yang J, Wang W, Li W, Wang X, Dong X, Yin X, Qu C, Ni B, Ni J
International journal of molecular sciences 2025 Jun 30;26(13)
International journal of molecular sciences 2025 Jun 30;26(13)
ENPP1 governs the metabolic regulation of effector T cells in autoimmunity by detecting cytosolic mitochondrial DNA.
Ji H, Jiang W, Zhang J, Liu M, Su D, Lei J, Li L, Zheng M, Liu T, Liu Z, Cao Q, Xu L, Xiong S, Wen Z
Cell reports 2025 Jun 24;44(6):115851
Cell reports 2025 Jun 24;44(6):115851
Therapeutic effects of Saussurea graminea Dunn and its active compounds in sepsis-associated liver injury: Transcriptomics, metabolomics and experimental validation.
Cui Y, Li Z, Lai M, Yang Y, Zhang Z, Feng Y, Yao M, Li J
Journal of ethnopharmacology 2025 Jun 12;349:119985
Journal of ethnopharmacology 2025 Jun 12;349:119985
Phosphorylation of syntenin-1 by TBK1 promotes proliferation and migration of non-small cell lung cancer cells.
Gao L, Zou H, Xie G, Li X, Chen Z
The Journal of biological chemistry 2025 Jul;301(7):110278
The Journal of biological chemistry 2025 Jul;301(7):110278
Inhibiting UGCG prevents PRV infection by decreasing lysosome-associated autophage.
Fan W, Yao C, Ma Y, Wang H, Liu P, Zhang Z, Chu B, Yang G, Wang M
International journal of biological macromolecules 2025 Jan;285:138303
International journal of biological macromolecules 2025 Jan;285:138303
The antiviral activity of myricetin against pseudorabies virus through regulation of the type I interferon signaling pathway.
Song Y, Zhao X, Chen Y, Yu X, Su T, Wang J, He T, Yin Z, Jia R, Zhao X, Zhou X, Li L, Zou Y, Li M, Zhang D, Zhang Y, Song X
Journal of virology 2025 Jan 31;99(1):e0156724
Journal of virology 2025 Jan 31;99(1):e0156724
MVK, induced by Kras, represses cGAS-Sting signalling in lung adenocarcinoma.
Zhou C, Liu J, Hu X, Lu L, Hou J, Wang J, Jiang L, Huang S, Lin Y, Liu L, Cui L, Liu Y, Huang Y
European journal of medical research 2025 Jan 22;30(1):43
European journal of medical research 2025 Jan 22;30(1):43
MYO1F positions cGAS on the plasma membrane to ensure full and functional signaling.
Wang H, Cui Z, Sun W, Yi M, Cheng Y, Zhang Y, Du Y, Pan T, Gao R, Feng L, Zeng B, Huang G, Li Y, Wang Y, Zhang CJ, He R, Wang C
Molecular cell 2025 Jan 2;85(1):150-165.e7
Molecular cell 2025 Jan 2;85(1):150-165.e7
Inhibition of LRRK2 Ameliorates Aspergillus fumigatus Keratitis by Regulating STING Signaling Pathways.
Han F, Wang L, Wu J, Shen L, Li Y, Guo H, Li J
Investigative ophthalmology & visual science 2025 Feb 3;66(2):13
Investigative ophthalmology & visual science 2025 Feb 3;66(2):13
β-Hydroxybutyrate-induced mitochondrial DNA (mtDNA) release mediated innate inflammatory response in bovine mammary epithelial cells by inhibiting autophagy.
Huo Y, Shen T, Feng T, Li M, Zhao W, Loor JJ, Aernouts B, Psifidi A, Xu C
Journal of animal science and biotechnology 2025 Feb 1;16(1):15
Journal of animal science and biotechnology 2025 Feb 1;16(1):15
Bavachinin exerts anti-tumor effects by activating TLR4/STING axis-dependent PANoptosis and synergistically enhances chemosensitivity in endometrial cancer.
Shu W, Chen G, Zhang J, Dong K, Zhou T, Cheng S, Zhang T, Zhang J, Li H, Yao Y, Yu S, Liu Y, Zhou X, Shen X, Wang H
Biochemical pharmacology 2025 Dec;242(Pt 2):117321
Biochemical pharmacology 2025 Dec;242(Pt 2):117321
HSYA targets the ZBP1-166R site to inhibit MAVS signaling: A potential therapeutic strategy for cerebral ischemia-reperfusion injury.
Sun H, Zhu K, Peng Y, Zhou X, Chang D, Wang N, Huang P
Cellular signalling 2025 Dec;136:112138
Cellular signalling 2025 Dec;136:112138
KAT2A affects the inflammatory progression of lupus nephritis through multilevel regulation of cGAS.
Tang Y, Zhang Y, Cao Q, Liu J, Zhuang Q
Journal of molecular medicine (Berlin, Germany) 2025 Dec 22;104(1):11
Journal of molecular medicine (Berlin, Germany) 2025 Dec 22;104(1):11
Linker histone H1.3 promotes IFN-β production targeting MDA5 signaling to inhibit EMCV infection.
Li H, Dou X, Wang N, Lian R, Li S, Xie J, Li X, Yang Y, Wen Y, Feng R
Molecular immunology 2025 Aug;184:137-148
Molecular immunology 2025 Aug;184:137-148
miR-30a enhanced RIG-I-mediated type I interferon antiviral response by targeting USP14.
Zhang J, Wang Y, Sun N, Zou B, Wang Z, Yin H, Xie J, Xia B, Sun N
Microbiology spectrum 2025 Aug 5;13(8):e0018825
Microbiology spectrum 2025 Aug 5;13(8):e0018825
Porcine epidemic diarrhea virus nsp14 inhibited IFN-Ⅰ production by targeting RIG-I for degradation.
Li S, Wang L, Wen Y, Han J, Hou J, Hou Z, Xie J, Li H, Li X, Yang Y, Feng R
Virology 2025 Apr;605:110451
Virology 2025 Apr;605:110451
Accumulation of Damaging Lipids in the Arf1-Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia.
Li X, Jin S, Wang D, Wu Y, Tang X, Liu Y, Yao T, Han S, Sun L, Wang Y, Hou SX
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(16):e2414260
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(16):e2414260
Comprehensive PTM profiling with SCASP-PTM uncovers mechanisms of p62 degradation and ALDOA-mediated tumor progression.
Lin ZP, Gan G, Xu X, Wen C, Ding X, Chen XY, Zhang K, Guo WY, Lin M, Wang YY, Chen X, Xie C, Wang J, Li M, Zhong CQ
Cell reports 2025 Apr 22;44(4):115500
Cell reports 2025 Apr 22;44(4):115500
An Immune Subtype Classification System Enables the Development of Strategies to Predict and Enhance Immunotherapy Responses in Colorectal Cancer.
Li D, Liu X, Gao W, Zhao W, Ji S, Wang S, Yang J, Li D, Chang Z, Chen Y, Sun X, Zhou J, Jiao Y, Du X, Dong G
Cancer research 2025 Apr 15;85(8):1441-1458
Cancer research 2025 Apr 15;85(8):1441-1458
mtDNA-cGAS-STING axis-dependent NLRP3 inflammasome activation contributes to postoperative cognitive dysfunction induced by sevoflurane in mice.
Yang NS, Zhong WJ, Sha HX, Zhang CY, Jin L, Duan JX, Xiong JB, You ZJ, Zhou Y, Guan CX
International journal of biological sciences 2024;20(5):1927-1946
International journal of biological sciences 2024;20(5):1927-1946
Neutrophil extracellular traps trigger alveolar epithelial cell necroptosis through the cGAS-STING pathway during acute lung injury in mice.
Sha HX, Liu YB, Qiu YL, Zhong WJ, Yang NS, Zhang CY, Duan JX, Xiong JB, Guan CX, Zhou Y
International journal of biological sciences 2024;20(12):4713-4730
International journal of biological sciences 2024;20(12):4713-4730
Activation of cGAS confers PARP inhibitor resistance in ovarian cancer via the TBK1-IRF3 axis.
Guo H, Lu R, Yuan S, Xu F, Huang C, Li J, Ge W, Geng Y, Zhang Y, Liu Q, Wang P, Li W
International journal of clinical and experimental pathology 2024;17(11):429-438
International journal of clinical and experimental pathology 2024;17(11):429-438
African swine fever virus MGF505-6R attenuates type I interferon production by targeting STING for degradation.
Yao M, Cao H, Li W, Hu Z, Rong Z, Yin M, Tian L, Hu D, Li X, Qian P
Frontiers in immunology 2024;15:1380220
Frontiers in immunology 2024;15:1380220
NSDHL promotes the degradation of sting in cholangiocarcinoma.
Yu W, Chen J, Tong Y, Zhu L, Deng Y, He J, Zhong C, Cai X
Heliyon 2024 Sep 15;10(17):e37592
Heliyon 2024 Sep 15;10(17):e37592
Targeting PRMT3 impairs methylation and oligomerization of HSP60 to boost anti-tumor immunity by activating cGAS/STING signaling.
Shi Y, Wu Z, Liu S, Zuo D, Niu Y, Qiu Y, Qiao L, He W, Qiu J, Yuan Y, Wang G, Li B
Nature communications 2024 Sep 10;15(1):7930
Nature communications 2024 Sep 10;15(1):7930
Glycyrrhetinic acid blocks SARS-CoV-2 infection by activating the cGAS-STING signalling pathway.
Qi H, Ma QH, Feng W, Chen SM, Wu CS, Wang Y, Wang TX, Hou YL, Jia ZH
British journal of pharmacology 2024 Oct;181(20):3976-3992
British journal of pharmacology 2024 Oct;181(20):3976-3992
STING Agonist Delivered by Neutrophil Membrane-Coated Gold Nanoparticles Exerts Synergistic Tumor Inhibition with Radiotherapy.
Lu D, Li W, Tan J, Li Y, Mao W, Zheng Y, Yang M, Wang J, Wang W, Wang S, Gao J, Liu Y
ACS applied materials & interfaces 2024 Oct 9;16(40):53474-53488
ACS applied materials & interfaces 2024 Oct 9;16(40):53474-53488
Homoplantaginin alleviates high glucose-induced vascular endothelial senescence by inhibiting mtDNA-cGAS-STING pathway via blunting DRP1-mitochondrial fission-VDAC1 axis.
Wang L, Zhang X, Huang X, Sha X, Li X, Zheng J, Li S, Wei Z, Wu F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Oct 31;38(20):e70127
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Oct 31;38(20):e70127
A TBK1-independent primordial function of STING in lysosomal biogenesis.
Lv B, Dion WA, Yang H, Xun J, Kim DH, Zhu B, Tan JX
Molecular cell 2024 Oct 17;84(20):3979-3996.e9
Molecular cell 2024 Oct 17;84(20):3979-3996.e9
The PRMT6/STAT1/ACSL1 axis promotes ferroptosis in diabetic nephropathy.
Hong J, Li X, Hao Y, Xu H, Yu L, Meng Z, Zhang J, Zhu M
Cell death and differentiation 2024 Nov;31(11):1561-1575
Cell death and differentiation 2024 Nov;31(11):1561-1575
TRIM32 inhibits Venezuelan equine encephalitis virus infection by targeting a late step in viral entry.
Xie Y, Cao J, Gan S, Xu L, Zhang D, Qian S, Xu F, Ding Q, Schoggins JW, Fan W
PLoS pathogens 2024 Nov;20(11):e1012312
PLoS pathogens 2024 Nov;20(11):e1012312
Angiopoietin 1 Relieves Osteolysis by Promoting Macrophage Mitophagy Through the TBK1-SQSTM1 Pathway to Inhibit AIM2 Inflammasome-Mediated Pyroptosis.
Yin J, Lai P, Zhu L, Ma J
Applied biochemistry and biotechnology 2024 Nov;196(11):7908-7927
Applied biochemistry and biotechnology 2024 Nov;196(11):7908-7927
Cadmium exposure triggers alveolar epithelial cell pyroptosis by inducing mitochondrial oxidative stress and activating the cGAS-STING pathway.
Zhang CY, Ou AJ, Jin L, Yang NS, Deng P, Guan CX, Huang XT, Duan JX, Zhou Y
Cell communication and signaling : CCS 2024 Nov 26;22(1):566
Cell communication and signaling : CCS 2024 Nov 26;22(1):566
Inactivation of Myostatin Delays Senescence via TREX1-SASP in Bovine Skeletal Muscle Cells.
Yang M, Gao L, Gao Y, Hao Z, Zhou X, Su G, Bai C, Wei Z, Liu X, Yang L, Li G
International journal of molecular sciences 2024 May 12;25(10)
International journal of molecular sciences 2024 May 12;25(10)
Salvianolic acid A prevents UV-induced skin damage by inhibiting the cGAS-STING pathway.
Zuo Z, He S, Qiu Y, Guo R, He Y, Jiao C, Xia Y, Liu W, Luan C, Guo W
International immunopharmacology 2024 May 10;132:111971
International immunopharmacology 2024 May 10;132:111971
CKLF induces microglial activation via triggering defective mitophagy and mitochondrial dysfunction.
Wang H, Ye J, Peng Y, Ma W, Chen H, Sun H, Feng Z, He W, Li G, Chu S, Zhang Z, Chen N
Autophagy 2024 Mar;20(3):590-613
Autophagy 2024 Mar;20(3):590-613
Non-canonical isoforms of the mRNA polyadenylation factor WDR33 regulate STING-mediated immune responses.
Liu L, Manley JL
Cell reports 2024 Mar 26;43(3):113886
Cell reports 2024 Mar 26;43(3):113886
IDI1 inhibits the cGAS-Sting signaling pathway in hepatocellular carcinoma.
Fu L, Ding H, Bai Y, Cheng L, Hu S, Guo Q
Heliyon 2024 Mar 15;10(5):e27205
Heliyon 2024 Mar 15;10(5):e27205
Pseudorabies virus manipulates mitochondrial tryptophanyl-tRNA synthetase 2 for viral replication.
Li XQ, Cai MP, Wang MY, Shi BW, Yang GY, Wang J, Chu BB, Ming SL
Virologica Sinica 2024 Jun;39(3):403-413
Virologica Sinica 2024 Jun;39(3):403-413
Flavonoid extracted from Epimedium attenuate cGAS-STING-mediated diseases by targeting the formation of functional STING signalosome.
Wang Y, Xu G, Wen J, Zhao X, Zhao H, Lv G, Xu Y, Xiu Y, Li J, Chen S, Yao Q, Chen Y, Ma L, Xiao X, Cao J, Bai Z
Immunology 2024 Jun;172(2):295-312
Immunology 2024 Jun;172(2):295-312
Mammalian reovirus µ1 protein attenuates RIG-I and MDA5-mediated signaling transduction by blocking IRF3 phosphorylation and nuclear translocation.
Wu B, Li D, Bai H, Mo R, Li H, Xie J, Zhang X, Yang Y, Li H, Idris A, Li X, Feng R
Molecular immunology 2024 Jun;170:131-143
Molecular immunology 2024 Jun;170:131-143
Compound Danshen Dripping Pill effectively alleviates cGAS-STING-triggered diseases by disrupting STING-TBK1 interaction.
Shi W, Xu G, Gao Y, Yang H, Liu T, Zhao J, Li H, Wei Z, Hou X, Chen Y, Wen J, Li C, Zhao J, Zhang P, Wang Z, Xiao X, Bai Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155404
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155404
TRIM32 inhibits Venezuelan Equine Encephalitis Virus Infection by targeting a late step in viral entry.
Xie Y, Cao J, Gan S, Xu L, Zhang D, Qian S, Xu F, Ding Q, Schoggins JW, Fan W
bioRxiv : the preprint server for biology 2024 Jun 4;
bioRxiv : the preprint server for biology 2024 Jun 4;
TBK1 pharmacological inhibition mitigates osteoarthritis through attenuating inflammation and cellular senescence in chondrocytes.
Lu R, Qu Y, Wang Z, He Z, Xu S, Cheng P, Lv Z, You H, Guo F, Chen A, Zhang J, Liang S
Journal of orthopaedic translation 2024 Jul;47:207-222
Journal of orthopaedic translation 2024 Jul;47:207-222
MARCH1 negatively regulates TBK1-mTOR signaling pathway by ubiquitinating TBK1.
Li X, Cheng K, Shang MD, Yang Y, Hu B, Wang X, Wei XD, Han YC, Zhang XG, Dong MH, Yang ZL, Wang JQ
BMC cancer 2024 Jul 26;24(1):902
BMC cancer 2024 Jul 26;24(1):902
Comparative proteomics analysis of kidney in chicken infected by infectious bronchitis virus.
Huang M, Zheng X, Zhang Y, Wang R, Wei X
Poultry science 2024 Jan;103(1):103259
Poultry science 2024 Jan;103(1):103259
Histone H1.2 Inhibited EMCV Replication through Enhancing MDA5-Mediated IFN-β Signaling Pathway.
Song Y, Li H, Lian R, Dou X, Li S, Xie J, Li X, Feng R, Li Z
Viruses 2024 Jan 24;16(2)
Viruses 2024 Jan 24;16(2)
PPM1G regulates hepatic ischemia/reperfusion injury through STING-mediated inflammatory pathways in macrophages.
Peng D, Huang Z, Yang H, Luo Y, Wu Z
Immunity, inflammation and disease 2024 Feb;12(2):e1189
Immunity, inflammation and disease 2024 Feb;12(2):e1189
Nitisinone attenuates cartilage degeneration and subchondral osteoclastogenesis in osteoarthritis and concomitantly inhibits the cGAS/STING/NF-κB pathway.
Yang T, Ma H, Lai H, Lu Y, Ni K, Hu X, Zhou Y, Zhou Z, Li W, Fang J, Zhang Y, Chen Z, He D
European journal of pharmacology 2024 Feb 15;965:176326
European journal of pharmacology 2024 Feb 15;965:176326
Polydatin attenuates diabetic renal inflammatory fibrosis via the inhibition of STING pathway.
Liang L, Zeng J, Liu R, Zheng Z, Lyu D, Zhang X, Wen M, Li M, Xiao H, Sun X, Li M, Huang H
Biochemical pharmacology 2024 Aug;226:116373
Biochemical pharmacology 2024 Aug;226:116373
SARS-CoV-2 spike-induced syncytia are senescent and contribute to exacerbated heart failure.
Li H, Wan L, Liu M, Ma E, Huang L, Yang Y, Li Q, Fang Y, Li J, Han B, Zhang C, Sun L, Hou X, Li H, Sun M, Qian S, Duan X, Zhao R, Yang X, Chen Y, Wu S, Zhang X, Zhang Y, Cheng G, Chen G, Gao Q, Xu J, Hou L, Wei C, Zhong H
PLoS pathogens 2024 Aug;20(8):e1012291
PLoS pathogens 2024 Aug;20(8):e1012291
STRAP upregulates antiviral innate immunity against PRV by targeting TBK1.
He W, Chang H, Li C, Wang C, Li L, Yang G, Chen J, Liu H
Virology journal 2024 Aug 24;21(1):197
Virology journal 2024 Aug 24;21(1):197
CDK4/6 Alters TBK1 Phosphorylation to Inhibit the STING Signaling Pathway in Prostate Cancer.
Li W, Guo F, Zeng R, Liang H, Wang Y, Xiong W, Wu H, Yang C, Jin X
Cancer research 2024 Aug 15;84(16):2588-2606
Cancer research 2024 Aug 15;84(16):2588-2606
mtDNA regulates cGAS-STING signaling pathway in adenomyosis.
Wang K, Wen Y, Fu X, Wei S, Liu S, Chen M
Free radical biology & medicine 2024 Apr;216:80-88
Free radical biology & medicine 2024 Apr;216:80-88
African swine fever virus pB318L, a trans-geranylgeranyl-diphosphate synthase, negatively regulates cGAS-STING and IFNAR-JAK-STAT signaling pathways.
Liu X, Chen H, Ye G, Liu H, Feng C, Chen W, Hu L, Zhou Q, Zhang Z, Li J, Zhang X, He X, Guan Y, Wu Z, Zhao D, Bu Z, Weng C, Huang L
PLoS pathogens 2024 Apr;20(4):e1012136
PLoS pathogens 2024 Apr;20(4):e1012136
Inhibition of cGAS aggravated the host inflammatory response to Aspergillus fumigatus.
Peng M, Li X, Zhang X, Peng L
Experimental lung research 2023;49(1):86-100
Experimental lung research 2023;49(1):86-100
Porcine reproductive and respiratory syndrome virus-mediated lactate facilitates virus replication by targeting MAVS.
Zhang L, Liu X, Mao J, Sun Y, Gao Y, Bai J, Jiang P
Veterinary microbiology 2023 Sep;284:109846
Veterinary microbiology 2023 Sep;284:109846
African Swine Fever Virus H240R Protein Inhibits the Production of Type I Interferon through Disrupting the Oligomerization of STING.
Ye G, Liu H, Liu X, Chen W, Li J, Zhao D, Wang G, Feng C, Zhang Z, Zhou Q, Zheng J, Bu Z, Weng C, Huang L
Journal of virology 2023 Sep 28;97(9):e0057723
Journal of virology 2023 Sep 28;97(9):e0057723
The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation.
Ouyang W, Wang S, Yan D, Wu J, Zhang Y, Li W, Hu J, Liu Z
Signal transduction and targeted therapy 2023 Sep 21;8(1):371
Signal transduction and targeted therapy 2023 Sep 21;8(1):371
STING/ACSL4 axis-dependent ferroptosis and inflammation promote hypertension-associated chronic kidney disease.
Gao L, Zhang J, Yang T, Jiang L, Liu X, Wang S, Wang X, Huang Y, Wang H, Zhang M, Gong T, Ma L, Li C, He C, Meng XM, Wu Y
Molecular therapy : the journal of the American Society of Gene Therapy 2023 Oct 4;31(10):3084-3103
Molecular therapy : the journal of the American Society of Gene Therapy 2023 Oct 4;31(10):3084-3103
Naringenin Improves Innate Immune Suppression after PRRSV Infection by Reactivating the RIG-I-MAVS Signaling Pathway, Promoting the Production of IFN-I.
Yu J, Shi H, Song K, Yang Y, Li X, Peng L, Fu B, Yi P
Viruses 2023 Oct 29;15(11)
Viruses 2023 Oct 29;15(11)
Flavonoids derived from licorice suppress LPS-induced acute lung injury in mice by inhibiting the cGAS-STING signaling pathway.
Wen J, Qin S, Li Y, Zhang P, Zhan X, Fang M, Shi C, Mu W, Kan W, Zhao J, Hui S, Hou M, Li H, Xiao X, Xu G, Bai Z
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 May;175:113732
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 May;175:113732
SMYD2 inhibition-mediated hypomethylation of Ku70 contributes to impaired nonhomologous end joining repair and antitumor immunity.
Tang M, Chen G, Tu B, Hu Z, Huang Y, DuFort CC, Wan X, Mao Z, Liu Y, Zhu WG, Lu W
Science advances 2023 Jun 16;9(24):eade6624
Science advances 2023 Jun 16;9(24):eade6624
mascRNA alleviates STING-TBK1 signaling-mediated immune response through promoting ubiquitination of STING.
Hu Y, Li X, Wang D, Mao X
Molecular immunology 2023 Feb;154:45-53
Molecular immunology 2023 Feb;154:45-53
Apoptotic tumor cell-derived microparticles loading Napabucasin inhibit CSCs and synergistic immune therapy.
Jing B, Guo F, An R, Gao Y, Li Y, Xie Y, Wang J, Chen Y, Li H, Gao T, Jin Q, Zhang L, Xie M
Journal of nanobiotechnology 2023 Feb 2;21(1):37
Journal of nanobiotechnology 2023 Feb 2;21(1):37
Inhibition of ACLY overcomes cancer immunotherapy resistance via polyunsaturated fatty acids peroxidation and cGAS-STING activation.
Xiang W, Lv H, Xing F, Sun X, Ma Y, Wu L, Lv G, Zong Q, Wang L, Wu Z, Feng Q, Yang W, Wang H
Science advances 2023 Dec 8;9(49):eadi2465
Science advances 2023 Dec 8;9(49):eadi2465
Glabridin improves autoimmune disease in Trex1-deficient mice by reducing type I interferon production.
Wen J, Mu W, Li H, Yan Y, Zhan X, Luo W, Wang Z, Kan W, Zhao J, Hui S, He P, Qin S, Xu Y, Zhang P, Xiao X, Xu G, Bai Z
Molecular medicine (Cambridge, Mass.) 2023 Dec 8;29(1):167
Molecular medicine (Cambridge, Mass.) 2023 Dec 8;29(1):167
A HER2-targeting antibody-MMAE conjugate RC48 sensitizes immunotherapy in HER2-positive colon cancer by triggering the cGAS-STING pathway.
Wu X, Xu L, Li X, Zhou Y, Han X, Zhang W, Wang W, Guo W, Liu W, Xu Q, Gu Y
Cell death & disease 2023 Aug 24;14(8):550
Cell death & disease 2023 Aug 24;14(8):550
A role of STING signaling in obesity-induced lung inflammation.
Qi Y, Wu Z, Chen D, Zhu L, Yang Y
International journal of obesity (2005) 2023 Apr;47(4):325-334
International journal of obesity (2005) 2023 Apr;47(4):325-334
Predicting the Immune Microenvironment and Prognosis with a NETosis-Related lncRNA Signature in Head and Neck Squamous Cell Carcinoma.
He X, Xiao Y, Liu S, Deng R, Li Z, Zhu X
BioMed research international 2022;2022:3191474
BioMed research international 2022;2022:3191474
Identification of highly specific antibodies for Serine/threonine-protein kinase TBK1 for use in immunoblot, immunoprecipitation and immunofluorescence.
Alshafie W, Fotouhi M, Shlaifer I, Ayoubi R, Edwards AM, Durcan TM, McPherson PS, Laflamme C
F1000Research 2022;11:977
F1000Research 2022;11:977
Circulating cell-free mtDNA release is associated with the activation of cGAS-STING pathway and inflammation in mitochondrial diseases.
Zhao X, Yu M, Zhao Y, Zheng Y, Meng L, Du K, Xie Z, Lv H, Zhang W, Liu J, Wang Q, Yuan Y, Wang Z, Deng J
Journal of neurology 2022 Sep;269(9):4985-4996
Journal of neurology 2022 Sep;269(9):4985-4996
Activation of cGAS-STING pathway - A possible cause of myofiber atrophy/necrosis in dermatomyositis and immune-mediated necrotizing myopathy.
Zhou M, Cheng X, Zhu W, Jiang J, Zhu S, Wu X, Liu M, Fang Q
Journal of clinical laboratory analysis 2022 Oct;36(10):e24631
Journal of clinical laboratory analysis 2022 Oct;36(10):e24631
STING pathway contributes to the prognosis of hepatocellular carcinoma and identification of prognostic gene signatures correlated to tumor microenvironment.
Pu Z, Liu J, Liu Z, Peng F, Zhu Y, Wang X, He J, Yi P, Hu X, Fan X, Chen J
Cancer cell international 2022 Oct 12;22(1):314
Cancer cell international 2022 Oct 12;22(1):314
eIF4A3 Promotes RNA Viruses' Replication by Inhibiting Innate Immune Responses.
Gao Q, Jiang M, Zhao Y, Li G, Yang C, Ren C, Jin M, Chen H, Zhou H
Journal of virology 2022 Nov 23;96(22):e0151322
Journal of virology 2022 Nov 23;96(22):e0151322
IKKε protects against starvation-induced NLRP3 inflammasome and pyroptosis in H9c2 cells by alleviating mitochondrial injury.
Chen G, Xu Y, Fan R, Liu Y, Yao Y, Jiang H, Wu Q, Li L, Chen W, Chen X
Biochemical and biophysical research communications 2022 Jan 22;589:267-274
Biochemical and biophysical research communications 2022 Jan 22;589:267-274
QKI deficiency in macrophages protects mice against JEV infection by regulating cell migration and antiviral response.
Deng L, Wang W, Bian P, Wu M, Wang L, Lei Y, Lu Z, Zhai D
Molecular immunology 2022 Aug;148:34-44
Molecular immunology 2022 Aug;148:34-44
TANK-Binding Kinase 1 (TBK1) Serves as a Potential Target for Hepatocellular Carcinoma by Enhancing Tumor Immune Infiltration.
Jiang Y, Chen S, Li Q, Liang J, Lin W, Li J, Liu Z, Wen M, Cao M, Hong J
Frontiers in immunology 2021;12:612139
Frontiers in immunology 2021;12:612139
PARP inhibitor niraparib as a radiosensitizer promotes antitumor immunity of radiotherapy in EGFR-mutated non-small cell lung cancer.
Zhang N, Gao Y, Zeng Z, Luo Y, Jiang X, Zhang J, Li J, Zhang J, Gong Y, Xie C
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2021 Sep;23(9):1827-1837
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2021 Sep;23(9):1827-1837
A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response.
Zhao Y, Sui L, Wu P, Wang W, Wang Z, Yu Y, Hou Z, Tan G, Liu Q, Wang G
Signal transduction and targeted therapy 2021 Sep 1;6(1):331
Signal transduction and targeted therapy 2021 Sep 1;6(1):331
The cGAS-STING signaling pathway contributes to the inflammatory response and autophagy in Aspergillus fumigatus keratitis.
Han F, Guo H, Wang L, Zhang Y, Sun L, Dai C, Wu X
Experimental eye research 2021 Jan;202:108366
Experimental eye research 2021 Jan;202:108366
African swine fever virus MGF505-11R inhibits type I interferon production by negatively regulating the cGAS-STING-mediated signaling pathway.
Yang K, Huang Q, Wang R, Zeng Y, Cheng M, Xue Y, Shi C, Ye L, Yang W, Jiang Y, Wang J, Huang H, Cao X, Yang G, Wang C
Veterinary microbiology 2021 Dec;263:109265
Veterinary microbiology 2021 Dec;263:109265
Stimulator of IFN genes mediates neuroinflammatory injury by suppressing AMPK signal in experimental subarachnoid hemorrhage.
Peng Y, Zhuang J, Ying G, Zeng H, Zhou H, Cao Y, Chen H, Xu C, Fu X, Xu H, Li J, Cao S, Chen J, Gu C, Yan F, Chen G
Journal of neuroinflammation 2020 May 25;17(1):165
Journal of neuroinflammation 2020 May 25;17(1):165
Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response.
Li M, Shu HB
Protein & cell 2020 Aug;11(8):584-599
Protein & cell 2020 Aug;11(8):584-599
No comments: Submit comment
No validations: Submit validation data