67912-1-Ig

antibody from Proteintech Group

Targeting: NR1I2 BXR, ONR1, PAR2, PXR, SXR

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Antibody Data

Product number

67912-1-Ig

Provider

Proteintech Group

Product name

PXR antibody

Antibody type

Monoclonal

Description

PXR antibody (Cat. #67912-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, Mouse, Rat and has been validated for the following applications: WB, ELISA.

Reactivity

Human, Mouse, Rat

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

1G3A7

Vial size

20ul, 150ul

References

Submitted references

Integrated single-cell transcriptomics and proteomics elucidate the molecular mechanisms and detoxification strategy of rifampicin-induced hepatotoxicity.

Chen J, Zhang Q, Huang J, He H, Bai Y, An Y, Hao M, Zhao W, Li W, Feng S, Yang S, Liao J, Wong YK, Dai L, Du Q, Luo P, Wang J
International journal of biological sciences 2026;22(1):481-499

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Schisandrin B Targets PXR to Enhance Bile Acid Metabolism and Alleviate ANIT-Induced Cholestatic Liver Injury via Dual Pathways.

Zhang Y, Lan H, Yu X, Zhuo L, Zhao B, Liu F, An L, Zhang F, Liu Z, Wang C
International journal of biological sciences 2026;22(1):387-409

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Determination of metabolic markers for lipid metabolism disorders and liver injury recovery via PXR/FXR-CYP7A1 regulation by Folium Ginkgo.

Wei X, Li D, Wu G, Xiao G, Zeng Z, Chi X, Chen Z
Journal of pharmaceutical and biomedical analysis 2026 Jan 15;268:117168

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PXR ribosylation at E194 amplifies NAPQI in acetaminophen‒induced liver injury in mice, rescued by Schisandrin B.

Long JC, Liu CX, Wang MY, Liu CH, Zhang F, Liu ZQ, An L, Wang CY
Acta pharmacologica Sinica 2026 Feb;47(2):370-382

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Ursolic acid drug-drug nanocrystals ameliorate cholestatic liver injury via inhibiting oxidative stress and regulating bile acid metabolism.

Hu M, Hua X, Xiong W, Zheng E, Yang X, Lu Y, He B, Zhong X, Jiang Z, Zhang Q, Liu Y
Frontiers in pharmacology 2025;16:1586141

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3-Indolepropionic acid confers PXR-p53 binding to mitigate deoxynivalenol-induced hepatocyte apoptosis.

Feng Y, Lin Z, Wang H, Men Z, Shen J, Ma X
Science China. Life sciences 2025 Sep;68(9):2707-2722

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Lithocholic acid ameliorates ulcerative colitis via the PXR/TLR4/NF-κB/NLRP3 signaling pathway and gut microbiota modulation.

Liu Y, Gao J, Chen L, Chen Y, Jiang J, Chen H, Ma L
Cellular and molecular life sciences : CMLS 2025 Sep 4;82(1):336

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Pregnane X receptor (PXR) as a prognostic marker and therapeutic target in kidney renal clear cell carcinoma (KIRC) via AMPK pathway regulation.

Hu WJ, Liu M, Bao YN, Su BW, Sui X, Cui XH, Wang GY, Wen L, Wen RK, Wang WH, Yang HX, Luan ZL
Scientific reports 2025 Oct 14;15(1):35808

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Pregnane X receptor increases urine concentration by upregulating hypothalamic arginine vasopressin expression.

Sun X, Li R, Luan Z, Ma B, Xu H, Luo T, Hu Y, Zhao W, Qiao R, Du C, Cao J, Zhou H, Guo Y, Zhong J, Zhang Y, Yang B, Guan Y, Zhang XY
American journal of physiology. Renal physiology 2025 Nov 1;329(5):F659-F672

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L-methionine promotes CD8(+) T cells killing hepatocellular carcinoma by inhibiting NR1I2/PCSK9 signaling.

Yuan C, Hu C, Zhou H, Liu W, Lai W, Liu Y, Yin Y, Li G, Zhang R
Neoplasia (New York, N.Y.) 2025 Jun;64:101160

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Cassia mimosoides L. decoction improves non-alcoholic fatty liver disease by modulating the pregnane X receptor.

Zhao J, Zhong Y, Huang Q, Pan Z, Zheng Y, Miao D, Liu S, Chen P, Liu C, Liu M, Shen C
Journal of ethnopharmacology 2025 Jan 31;340:119199

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Activation of nuclear receptor pregnane-X-receptor protects against abdominal aortic aneurysm by inhibiting oxidative stress.

Shen Z, Wang J, Chen Y, Fang P, Yuan A, Chen AF, Yan X, Lyu Y, Pu J
Redox biology 2024 Nov;77:103397

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Triptolide-induced acute liver injury and its mechanism with estradiol in regulating macrophage-mediated inflammation and hepatocyte function.

Zhang X, Cao Z, Li L, Lu P, Geng Q, Yan L, Liu B, Lin L, Zhang L, Shi C, Tan Y, He X, Li L, Zhao N, Lu C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117481

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Pregnane X Receptor Activation in Liver Macrophages Protects against Endotoxin-Induced Liver Injury.

Zhao T, Zhong G, Wang Y, Cao R, Song S, Li Y, Wan G, Sun H, Huang M, Bi H, Jiang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(19):e2308771

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PXR Activation Relieves Deoxynivalenol-Induced Liver Oxidative Stress Via Malat1 LncRNA m(6)A Demethylation.

Feng Y, Shen J, Lin Z, Chen Z, Zhou M, Ma X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jul;11(25):e2308742

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Bacteroides dorei BDX-01 alleviates DSS-induced experimental colitis in mice by regulating intestinal bile salt hydrolase activity and the FXR-NLRP3 signaling pathway.

Sun X, Chen Z, Yu L, Zeng W, Sun B, Fan H, Bai Y
Frontiers in pharmacology 2023;14:1205323

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Metabolic characteristics of voriconazole - Induced liver injury in rats.

Du Q, Teng M, Yang L, Meng C, Qiu Y, Wang C, Chen J, Wang T, Chen S, Luo Y, Sun J, Dong Y
Chemico-biological interactions 2023 Sep 25;383:110693

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Pregnane X receptor activation alleviates renal fibrosis in mice via interacting with p53 and inhibiting the Wnt7a/β-catenin signaling.

Ming WH, Luan ZL, Yao Y, Liu HC, Hu SY, Du CX, Zhang C, Zhao YH, Huang YZ, Sun XW, Qiao RF, Xu H, Guan YF, Zhang XY
Acta pharmacologica Sinica 2023 Oct;44(10):2075-2090

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Resveratrol attenuates efavirenz-induced hepatic steatosis and hypercholesterolemia in mice by inhibiting pregnane X receptor activation and decreasing inflammation.

Miao X, Ye H, Cui X, Guo X, Su F
Nutrition research (New York, N.Y.) 2023 Nov;119:119-131

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Panaxytriol upregulates CYP3A4 expression through the interaction between nuclear regulators and DNA response elements.

Yan J, Gu Q, Meng C, Liu J, Liu F, Xia C
Journal of ethnopharmacology 2023 Jun 28;310:116398

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Type 1 diabetes and diet-induced obesity predispose C57BL/6J mice to PM(2.5)-induced lung injury: a comparative study.

Chen S, Li M, Zhang R, Ye L, Jiang Y, Jiang X, Peng H, Wang Z, Guo Z, Chen L, Zhang R, Niu Y, Aschner M, Li D, Chen W
Particle and fibre toxicology 2023 Apr 17;20(1):10

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Panaxytriol upregulates CYP3A4 expression based on the interaction of PXR, CAR, HSP90α, and RXRα.

Zhang L, Yan J, Liu J, Meng C, Liu F, Xia C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jul;101:154097

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CD36 and DGAT2 facilitate the lipid-lowering effect of chitooligosaccharides via fatty acid intake and triglyceride synthesis signaling.

Shen X, Liang X, Ji X, You J, Zhuang X, Song Y, Yin H, Zhao M, Zhao L
Food & function 2021 Sep 20;12(18):8681-8693