Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- BS3480 - Provider product page
- Provider
- Bioworld Technology, Inc
- Proper citation
- Bioworld Technology Cat#BS3480, RRID:AB_1662313
- Product name
- IL 12B (V277) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 245-291 of Human IL-12B.
- Description
- IL-12 is secreted by macrophages and human B-lymphoblastoid cells in response to antigenic stimulation. This IL is responsible for the differentiation of naive CD4+ T cells into type 1 helper T cells that produce interferon-ÎÛ (IFN-ÎÛ). It also activates production of tumor necrosis factor Ï« (TNFÏ«) from T and natural killer (NK) cells, and it inhibits IL-4 mediated suppression of IFN-ÎÛ. IL-12 also has anti-angiogenic activity since the production of IFN-ÎÛ increases the production of inducible protein-10 (IP-10). IL-12 p40 represents a subunit of IL-12 that is induced by several pathogens. IL-12 p70 is a subunit of IL-12 that is controlled through both the p35 and p40 genes in a cell type-specific fashion.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of IL-12B (V277) pAb at 1:500 dilutionLane1:HEK293A whole cell lysateLane2:Raw264.7 whole cell lysateLane3:H9C2 whole cell lysate