MAB6091

antibody from R&D Systems

Targeting: IL12B CLMF, CLMF2, IL-12B, NKSF, NKSF2

Western blot (Recommended by provider)

Antibody Data

Product number

MAB6091

Provider

R&D Systems

Product name

Anti-Human IL-12/IL-23 p40 Monoclonal Antibody (Clone 169516)

Antibody type

Monoclonal

Antigen

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human IL-23 p19/p40 heterodimer, Ile23-Ser328

Description

Protein A or G purified from hybridoma culture supernatant

Reactivity

Human

Host

Mouse

Antigen sequence

P29460


Isotype

IgG

Vial size

500 µg

References

Submitted references

A naturally occurring, soluble antagonist of human IL-23 inhibits the development and in vitro function of human Th17 cells.

Yu RY, Gallagher G
Journal of immunology (Baltimore, Md. : 1950) 2010 Dec 15;185(12):7302-8

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IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production.

Vaknin-Dembinsky A, Balashov K, Weiner HL
Journal of immunology (Baltimore, Md. : 1950) 2006 Jun 15;176(12):7768-74