10991-1-AP

antibody from Proteintech Group

Targeting: FHL1 bA535K18.1, FHL1B, FLH1A, KYO-T, MGC111107, SLIM1, XMPMA

Provider product page for 10991-1-AP

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Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [28]
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Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 10991-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10991-1-AP, RRID:AB_2104230
Product name: FHL1 antibody
Antibody type: Polyclonal
Description: KD/KO validated FHL1 antibody (Cat. #10991-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, zebrafish, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat, Zebrafish
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

FHL1 protein structure - 10991-1-AP shown in red.

Submitted references Modulation of Titin and Contraction-Regulating Proteins in a Rat Model of Heart Failure with Preserved Ejection Fraction: Limb vs. Diaphragmatic Muscle.

Vahle B, Heilmann L, Schauer A, Augstein A, Jarabo MP, Barthel P, Mangner N, Labeit S, Bowen TS, Linke A, Adams V
International journal of molecular sciences 2024 Jun 16;25(12)

Tabersonine Enhances Olaparib Sensitivity through FHL1-Mediated Epithelial-Mesenchymal Transition in an Ovarian Tumor.

Chen X, Yan Y, Liu Y, Yi Q, Xu Z
Journal of natural products 2024 Apr 26;87(4):837-848

Insulin-like growth factor receptor / mTOR signaling elevates global translation to accelerate zebrafish fin regenerative outgrowth.

Lewis VM, Le Bleu HK, Henner AL, Markovic H, Robbins AE, Stewart S, Stankunas K
Developmental biology 2023 Oct;502:1-13

Immortalization-upregulated protein promotes pancreatic cancer progression by regulating NPM1/FHL1-mediated cell-cycle-checkpoint protein activity.

Luo Q, Pan Y, Fu Q, Zhang X, Zhou S, Yu P, Tian H, Liu P, Chen S, Zhang H, Qin T
Cell biology and toxicology 2023 Oct;39(5):2069-2087

FHL1 promotes chikungunya and o'nyong-nyong virus infection and pathogenesis with implications for alphavirus vaccine design.

Ng WH, Liu X, Ling ZL, Santos CNO, Magalhães LS, Kueh AJ, Herold MJ, Taylor A, Freitas JR, Koit S, Wang S, Lloyd AR, Teixeira MM, Merits A, Almeida RP, King NJC, Mahalingam S
Nature communications 2023 Oct 26;14(1):6605

Identification of novel FHL1 mutations associated with X-linked scapuloperoneal myopathy in unrelated Chinese patients.

Lin Y, Ban R, Qiao L, Chen J, Liu M, Liu J, Shi Q
Journal of human genetics 2023 Jul;68(7):477-484

Disruption of the CCDC43-FHL1 interaction triggers apoptosis in gastric cancer cells.

Chen Y, Pei M, Li J, Wang Z, Liu S, Xiang L, Zhang J, Hong L, Lin J, Dai W, Xiao Y, Hu H, Tang W, Liu G, Yang Q, Lin Z, Jiang X, Wang Y, Wu X, Guo Z, Wang J
Experimental cell research 2022 Jun 1;415(1):113107

Inhibition of Jumonji demethylases reprograms severe dilated cardiomyopathy and prolongs survival.

Tran TA, Zhang QJ, Wang L, Gonzales C, Girard L, May H, Gillette T, Liu ZP, Martinez ED
The Journal of biological chemistry 2022 Feb;298(2):101515

Downregulation of FHL1 protein in glioma inhibits tumor growth through PI3K/AKT signaling.

Li SZ, Hu YY, Zhao JL, Zang J, Fei Z, Han H, Qin HY
Oncology letters 2020 Jun;19(6):3781-3788

Structural and Functional Characterization of Host FHL1 Protein Interaction with Hypervariable Domain of Chikungunya Virus nsP3 Protein.

Lukash T, Agback T, Dominguez F, Shiliaev N, Meshram C, Frolova EI, Agback P, Frolov I
Journal of virology 2020 Dec 9;95(1)

Hu Z, Zhu Y, Liu X, Zhang W, Liu J, Wu S, Xiao J, Yuan Y, Wang Z
Journal of human genetics 2019 Sep;64(9):919-926

Hypoxia-induced alterations in the lung ubiquitin proteasome system during pulmonary hypertension pathogenesis.

Wade BE, Zhao J, Ma J, Hart CM, Sutliff RL
Pulmonary circulation 2018 Jul-Sep;8(3):2045894018788267

Src-mediated phosphorylation converts FHL1 from tumor suppressor to tumor promoter.

Wang X, Wei X, Yuan Y, Sun Q, Zhan J, Zhang J, Tang Y, Li F, Ding L, Ye Q, Zhang H
The Journal of cell biology 2018 Apr 2;217(4):1335-1351

Role of Zebrafish fhl1A in Satellite Cell and Skeletal Muscle Development.

Chen F, Yuan W, Mo X, Zhuang J, Wang Y, Chen J, Jiang Z, Zhu X, Zeng Q, Wan Y, Li F, Shi Y, Cao L, Fan X, Luo S, Ye X, Chen Y, Dai G, Gao J, Wang X, Xie H, Zhu P, Li Y, Wu X
Current molecular medicine 2017;17(9):627-636

A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity.

Xu X, Fan Z, Liang C, Li L, Wang L, Liang Y, Wu J, Chang S, Yan Z, Lv Z, Fu J, Liu Y, Jin S, Wang T, Hong T, Dong Y, Ding L, Cheng L, Liu R, Fu S, Jiao S, Ye Q
Nature communications 2017 Jan 17;8:14059

Browning of human adipocytes requires KLF11 and reprogramming of PPARγ superenhancers.

Loft A, Forss I, Siersbæk MS, Schmidt SF, Larsen AS, Madsen JG, Pisani DF, Nielsen R, Aagaard MM, Mathison A, Neville MJ, Urrutia R, Karpe F, Amri EZ, Mandrup S
Genes & development 2015 Jan 1;29(1):7-22

MiR-410 is overexpressed in liver and colorectal tumors and enhances tumor cell growth by silencing FHL1 via a direct/indirect mechanism.

Wang Y, Fu J, Jiang M, Zhang X, Cheng L, Xu X, Fan Z, Zhang J, Ye Q, Song H
PloS one 2014;9(10):e108708

FHL1C induces apoptosis in Notch1-dependent T-ALL cells through an interaction with RBP-J.

Fu W, Wang K, Zhao JL, Yu HC, Li SZ, Lin Y, Liang L, Huang SY, Liang YM, Han H, Qin HY
BMC cancer 2014 Jun 22;14:463

The LIM domain protein FHL1C interacts with tight junction protein ZO-1 contributing to the epithelial-mesenchymal transition (EMT) of a breast adenocarcinoma cell line.

Zhao JL, Liang SQ, Fu W, Zhu BK, Li SZ, Han H, Qin HY
Gene 2014 Jun 1;542(2):182-9

The LIM protein fhlA is essential for heart chamber development in zebrafish embryos.

Xie H, Fan X, Tang X, Wan Y, Chen F, Wang X, Wang Y, Li Y, Tang M, Liu D, Jiang Z, Liu X, Yuan W, Li G, Ye X, Zhou J, Mo X, Deng Y, Wu X
Current molecular medicine 2013 Jul;13(6):979-92

Evaluation of protein expression pattern of stanniocalcin 2, insulin-like growth factor-binding protein 7, inhibin beta A and four and a half LIM domains 1 in esophageal squamous cell carcinoma.

Kashyap MK, Pawar HA, Keerthikumar S, Sharma J, Goel R, Mahmood R, Kumar MV, Kumar KV, Pandey A, Kumar RV, Prasad TS, Harsha HC
Cancer biomarkers : section A of Disease markers 2012-2013;12(1):1-9

FHL family members suppress vascular endothelial growth factor expression through blockade of dimerization of HIF1α and HIF1β.

Lin J, Qin X, Zhu Z, Mu J, Zhu L, Wu K, Jiao H, Xu X, Ye Q
IUBMB life 2012 Nov;64(11):921-30

Downregulation and growth inhibitory role of FHL1 in lung cancer.

Niu C, Liang C, Guo J, Cheng L, Zhang H, Qin X, Zhang Q, Ding L, Yuan B, Xu X, Li J, Lin J, Ye Q
International journal of cancer 2012 Jun 1;130(11):2549-56

FHL1 interacts with oestrogen receptors and regulates breast cancer cell growth.

Ding L, Niu C, Zheng Y, Xiong Z, Liu Y, Lin J, Sun H, Huang K, Yang W, Li X, Ye Q
Journal of cellular and molecular medicine 2011 Jan;15(1):72-85

MAL/MRTF-A controls migration of non-invasive cells by upregulation of cytoskeleton-associated proteins.

Leitner L, Shaposhnikov D, Mengel A, Descot A, Julien S, Hoffmann R, Posern G
Journal of cell science 2011 Dec 15;124(Pt 24):4318-31

CpG hypermethylation of human four-and-a-half LIM domains 1 contributes to migration and invasion activity of human bladder cancer.

Matsumoto M, Kawakami K, Enokida H, Toki K, Matsuda R, Chiyomaru T, Nishiyama K, Kawahara K, Seki N, Nakagawa M
International journal of molecular medicine 2010 Aug;26(2):241-7

Four and a half LIM domains 1 (FHL1) and receptor interacting protein of 140kDa (RIP140) interact and cooperate in estrogen signaling.

Lin J, Ding L, Jin R, Zhang H, Cheng L, Qin X, Chai J, Ye Q
The international journal of biochemistry & cell biology 2009 Jul;41(7):1613-8

Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway.

Ding L, Wang Z, Yan J, Yang X, Liu A, Qiu W, Zhu J, Han J, Zhang H, Lin J, Cheng L, Qin X, Niu C, Yuan B, Wang X, Zhu C, Zhou Y, Li J, Song H, Huang C, Ye Q
The Journal of clinical investigation 2009 Feb;119(2):349-61

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human brain tissue were subjected to SDS PAGE followed by western blot with 10991-1-AP(FHL1 antibody) at dilution of 1:1000
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The FHL1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human FHL1. This antibody recognizes human, mouse, rat antigen. The FHL1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 10991-1-AP.pdf

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