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- Antibody Data
- Antigen structure
- References [6]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 51027-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#51027-2-AP, RRID:AB_615013
- Product name
- MECR antibody
- Antibody type
- Polyclonal
- Description
- Mecr antibody (Cat. #51027-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references A novel lipid metabolism-based risk model associated with immunosuppressive mechanisms in diffuse large B-cell lymphoma.
An engineered variant of MECR reductase reveals indispensability of long-chain acyl-ACPs for mitochondrial respiration.
Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria.
Impaired Mitochondrial Fatty Acid Synthesis Leads to Neurodegeneration in Mice.
Genetic modifications of Mecr reveal a role for mitochondrial 2-enoyl-CoA/ACP reductase in placental development in mice.
MECR Mutations Cause Childhood-Onset Dystonia and Optic Atrophy, a Mitochondrial Fatty Acid Synthesis Disorder.
Zhang Z, Zhao C, Yang S, Lu W, Shi J
Lipids in health and disease 2024 Jan 22;23(1):20
Lipids in health and disease 2024 Jan 22;23(1):20
An engineered variant of MECR reductase reveals indispensability of long-chain acyl-ACPs for mitochondrial respiration.
Rahman MT, Koski MK, Panecka-Hofman J, Schmitz W, Kastaniotis AJ, Wade RC, Wierenga RK, Hiltunen JK, Autio KJ
Nature communications 2023 Feb 4;14(1):619
Nature communications 2023 Feb 4;14(1):619
Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria.
Nowinski SM, Solmonson A, Rusin SF, Maschek JA, Bensard CL, Fogarty S, Jeong MY, Lettlova S, Berg JA, Morgan JT, Ouyang Y, Naylor BC, Paulo JA, Funai K, Cox JE, Gygi SP, Winge DR, DeBerardinis RJ, Rutter J
eLife 2020 Aug 17;9
eLife 2020 Aug 17;9
Impaired Mitochondrial Fatty Acid Synthesis Leads to Neurodegeneration in Mice.
Nair RR, Koivisto H, Jokivarsi K, Miinalainen IJ, Autio KJ, Manninen A, Poutiainen P, Tanila H, Hiltunen JK, Kastaniotis AJ
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Nov 7;38(45):9781-9800
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Nov 7;38(45):9781-9800
Genetic modifications of Mecr reveal a role for mitochondrial 2-enoyl-CoA/ACP reductase in placental development in mice.
Nair RR, Kerätär JM, Autio KJ, Masud AJ, Finnilä MAJ, Autio-Harmainen HI, Miinalainen IJ, Nieminen PA, Hiltunen JK, Kastaniotis AJ
Human molecular genetics 2017 Jun 1;26(11):2104-2117
Human molecular genetics 2017 Jun 1;26(11):2104-2117
MECR Mutations Cause Childhood-Onset Dystonia and Optic Atrophy, a Mitochondrial Fatty Acid Synthesis Disorder.
Heimer G, Kerätär JM, Riley LG, Balasubramaniam S, Eyal E, Pietikäinen LP, Hiltunen JK, Marek-Yagel D, Hamada J, Gregory A, Rogers C, Hogarth P, Nance MA, Shalva N, Veber A, Tzadok M, Nissenkorn A, Tonduti D, Renaldo F, University of Washington Center for Mendelian Genomics, Kraoua I, Panteghini C, Valletta L, Garavaglia B, Cowley MJ, Gayevskiy V, Roscioli T, Silberstein JM, Hoffmann C, Raas-Rothschild A, Tiranti V, Anikster Y, Christodoulou J, Kastaniotis AJ, Ben-Zeev B, Hayflick SJ
American journal of human genetics 2016 Dec 1;99(6):1229-1244
American journal of human genetics 2016 Dec 1;99(6):1229-1244
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse heart tissue were subjected to SDS PAGE followed by western blot with 51027-2-AP(Mecr antibody) at dilution of 1:3000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Mecr antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of mouse Mecr. This antibody recognizes human, mouse, rat antigen. The Mecr antibody has been validated for the following applications: ELISA, WB, IHC analysis.
