66645-1-Ig

antibody from Proteintech Group

Targeting: TLR2 CD282, TIL4

Provider product page for 66645-1-Ig

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Antibody data

Antibody Data
Antigen structure
References [45]
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Product number: 66645-1-Ig - Provider product page
Provider: Proteintech Group
Product name: TLR2 antibody
Antibody type: Monoclonal
Description: KD/KO validated TLR2 antibody (Cat. #66645-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human and has been validated for the following applications: WB,ELISA.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 1C1D3
Vial size: 20ul, 150ul

TLR2 protein structure - 66645-1-Ig shown in red.

Submitted references NAT10 Promotes Tubular Epithelial Cell Senescence in Cisplatin-Induced Acute Kidney Injury by Regulating DDX17.

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Xie Y, Hu Y, Huang J, Liu J, Zhang Q
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Isolation, structural characterization and immunoregulatory activity of a novel acidic polysaccharide from Ganoderma sinense.

Zhang M, Wu J, Xu J, Hu X, Shi H, Huang W, Song L, Zhu J, Tan H, Yu R
International journal of biological macromolecules 2026 Mar;352:151196

Bushen Huoxue Recipe enhances the immune microenvironment at the maternal-fetal interface via the Hippo signaling pathway in mice with recurrent spontaneous abortion.

Xia L, Huang S, Huang H, Han X, Dong L, Xia Y
Journal of traditional and complementary medicine 2026 Mar;16(2):154-164

Febuxostat alleviates gout-associated hyperuricemia and inflammation by downregulating IL1A to modulate TLR2/TLR4/NF-κB signaling pathway.

Hu M, Zhou Y, Zhang Y, Pan F, Liu M
International immunopharmacology 2026 Jan 1;168(Pt 2):115935

Astaxanthin protects against acute lung injury via dual modulation of Ca(2+)/CaMKIIα/NLRP3 and TLR2/MyD88/NLRP3 pathways.

Cui K, Wang J, Chen K, Ge W, Zhou J, Zhang R, Fan X
International immunopharmacology 2026 Jan 1;168(Pt 1):115776

Age-associated methionine sulfoxide reductase A protects against valvular interstitial cell senescence and valvular calcification.

Li Q, Song C, Wei Z, Zhou H, Wang S, Li H, Yang H, Luo Q, Li J, Chen M
GeroScience 2026 Feb;48(1):807-827

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Zhu C, Shi Y, Zhou Z, Shao Y, Wang J, Sun Z, Bian M
Journal of ethnopharmacology 2026 Feb 10;356:120830

Protective effect of Zymosan-A against radiation-induced premature ovarian insufficiency in a murine model.

Yu Y, Du J, Li B, Cheng Y, Lin F, Zhou J, Song Y, Liu C, Cai S
iScience 2026 Apr 17;29(4):115027

Integrated transcriptomic and proteomic analyses identify the TLR2-CXCR4 axis as a regulator of endothelial cell migration under simulated microgravity.

Qin X, Wang R, Li C, Pan Y, Wang Y, Sun X
Frontiers in physiology 2025;16:1701338

POSTN-Mediated Interplay of M1 Polarized Macrophage with Tendon-Derived Stem Cells to Drive Traumatic Heterotopic Ossification Formation through PTK7/ATK Signaling?

Liu H, Li X, Li M, Sun Z, Wang X, Li J, Xu B, Chen Q, Fan C, Ruan H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(40):e07951

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He L, Qiang R, Li W
European journal of medical research 2025 Oct 9;30(1):947

Fusobacterium nucleatum increases CTGF expression through TLR2-YAP signaling axis in cancer-associated fibroblasts, thereby promoting colorectal cancer progression.

Wang H, Lin B, Wang Z, Yang J, Guo X, Li W, Li B, Shi S, Zhou Y, Han R, Wei Y, Liu Y
Cancer cell international 2025 Oct 28;25(1):381

Integrated bioinformatics decoding of the MASLD ceRNA network reveals novel therapeutic targets.

Yu S, Jiang X, Peng L, Zeng X, Wen S, Xiong H, Guo S, Huang F, Liu H, Luo Q
Clinical and experimental medicine 2025 Nov 6;25(1):354

Extracellular HSP70 facilitated β-glucan induced trained immunity in macrophages to suppress sepsis via TLR2-NF-κB axis.

Qi R, Cheng X, Chen S, Fan J
Cytokine 2025 Mar;187:156861

Immunomodulatory activity and molecular mechanisms of action of peptides derived from casein hydrolysate by alcalase and flavourzyme based on virtual screening.

Jiang Y, Li S, Jiang L, Mu G, Jiang S
Journal of dairy science 2025 Mar;108(3):2152-2168

Role of CORO1A in Regulating Immune Homeostasis of Mammary Glands and Its Contribution to Clinical Mastitis Development in Dairy Cows.

Zhang B, Chen N, Yu X, Li J, Dong W, Zhang Y, Zhao X, Zhang Q
Biomolecules 2025 Jun 6;15(6)

Ginsenoside Rg1 targets TLR2 to inhibit the NF-κB signaling pathway and ameliorate hematopoietic support of mesenchymal stromal cells.

Wei H, Liu Y, Huang C, Wang C, Jiang H, Wang L, Wang Y, Wang Z
Journal of ethnopharmacology 2025 Jun 12;349:119917

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Han F, Wang L, Wu J, Shen L, Li Y, Guo H, Li J
Investigative ophthalmology & visual science 2025 Feb 3;66(2):13

Yinchen-Gancao decoction ameliorated NASH in mice by reducing hepatic lipid accumulation, inhibiting hepatic inflammatory and endoplasmic reticulum stress.

Zhao J, Jin J, Li Y, Zhang S, Li F, Cui J, Wang Z, Yan D, Qiu F
Journal of ethnopharmacology 2025 Feb 11;341:119318

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Sheng M, Liu W, Cao Y, Wang S, Lin Y, Yu W
Shock (Augusta, Ga.) 2025 Feb 1;63(2):292-298

Jin KJ, Pan L, Huang CX, Yin C, Wang Y, Zhang J, Gong H
Current medical science 2025 Aug;45(4):819-830

EZH2-mediated suppression of TIMP1 in spinal GABAergic interneurons drives microglial activation via MMP-9-TLR2/4-NLRP3 signaling in neuropathic pain.

Wan L, Guo H, Hu F, Pan Y, Yang S, Jiang CY, Liu W, Wu X, Wu X
Brain, behavior, and immunity 2025 Aug;128:234-255

Calreticulin in the nasal mucus promotes neutrophil migration and pathogen clearance.

Ma Y, Qin X, Liu S, Lin R, Meng B, Lin J, Yang Q
Cell communication and signaling : CCS 2025 Aug 26;23(1):381

miR-328-3p targets TLR2 to ameliorate oxygen-glucose deprivation injury and neutrophil extracellular trap formation in HUVECs via inhibition of the NF-κB signaling pathway.

Yao M, Fang C, Wang Z, Guo T, Wu D, Ma J, Wu J, Mo J
PloS one 2024;19(2):e0299382

p53 suppresses the inflammatory response following respiratory syncytial virus infection by inhibiting TLR2.

Liu J, Gao L, Zhou N, Jiang Z, Che S, Deng Y, Zang N, Ren L, Xie X, Xie J, Liu E
Virology 2024 May;593:110018

Polyphyllin B inhibited STAT3/NCOA4 pathway and restored gut microbiota to ameliorate lung tissue injury in cigarette smoke-induced mice.

Wang Q, He Z, Zhu J, Hu M, Yang L, Yang H
BMC biotechnology 2024 Mar 8;24(1):13

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Li J, Liu H, Fu H, Yang Y, Wu Z
Journal of agricultural and food chemistry 2024 Jun 12;72(23):13415-13430

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Yang L, Mei GC, Wu JX, Jiang QZ, Su ZH, Liao HQ, Liu ZM, Tao RC, Yong XZ
Microbes and infection 2024 Jan-Feb;26(1-2):105244

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Liu B, Fan L, Wang Y, Wang H, Yan Y, Chen S, Hung I, Liu C, Wei H, Ge L, Ren W
Gut microbes 2024 Jan-Dec;16(1):2313769

The novel mechanism of human norovirus induced diarrhea: Activation of PKD2 caused by HuNoVs destroyed AQP3 expression through AP2γ in intestinal epithelial cells.

Huang L, Xie S, Zhang Y, Du W, Liang X, Pan W, Yang F, Niu R, Chen H, Geng L, Xiang L, Gong S, Xu W
Life sciences 2024 Jan 15;337:122348

Identification of key neutrophil extracellular trap genes in Alzheimer's disease.

Pan H, Wang G, Bi Z, Lai C, Wang M
Journal of Alzheimer's disease : JAD 2024 Dec;102(4):1027-1041

Baicalin Reduces Immune Cell Infiltration by Inhibiting Inflammation and Protecting Tight Junctions in Ischemic Stroke Injury.

Hao Z, Zhang Z, Zhao Y, Wang D
The American journal of Chinese medicine 2023;51(2):355-372

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Cui L, Zeng H, Hou M, Li Z, Mu C, Zhu W, Hang S
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2023 Sep;14:370-382

Tea Polyphenols Protects Tracheal Epithelial Tight Junctions in Lung during Actinobacillus pleuropneumoniae Infection via Suppressing TLR-4/MAPK/PKC-MLCK Signaling.

Li X, Liu Z, Gao T, Liu W, Yang K, Guo R, Li C, Tian Y, Wang N, Zhou D, Bei W, Yuan F
International journal of molecular sciences 2023 Jul 24;24(14)

Holothuria leucospilota Polysaccharides Improve Immunity and the Gut Microbiota in Cyclophosphamide-Treated Immunosuppressed Mice.

Zhao F, Ma T, Zhang X, Zhao Q, Zhu K, Cao J, Liu Z, Shen X, Li C
Molecular nutrition & food research 2023 Apr;67(8):e2200317

Lactobacillus fermentum CECT5716 Alleviates the Inflammatory Response in Asthma by Regulating TLR2/TLR4 Expression.

Wang W, Li Y, Han G, Li A, Kong X
Frontiers in nutrition 2022;9:931427

Zhuifeng tougu capsules inhibit the TLR4/MyD88/NF-κB signaling pathway and alleviate knee osteoarthritis: In vitro and in vivo experiments.

Xu X, Li N, Wu Y, Yan K, Mi Y, Yi N, Tan X, Kuang G, Lu M
Frontiers in pharmacology 2022;13:951860

PPARγ Ameliorates Mycobacterium tuberculosis H37Ra-Induced Foamy Macrophage Formation via the ABCG1-Dependent Cholesterol Efflux Pathway in THP-1 Macrophages.

Ye Y, Liu J, Guo Y, Gao Y, Rao J, Su R, Zhang L, Huang Z, Luo Q, Li J
Frontiers in microbiology 2022;13:829870

Distinct immune and inflammatory response patterns contribute to the identification of poor prognosis and advanced clinical characters in bladder cancer patients.

Chang Z, Li R, Zhang J, An L, Zhou G, Lei M, Deng J, Yang R, Song Z, Zhong W, Qi D, Duan X, Li S, Sun B, Wu W
Frontiers in immunology 2022;13:1008865

Monocyte biomarkers define sargramostim treatment outcomes for Parkinson's disease.

Abdelmoaty MM, Machhi J, Yeapuri P, Shahjin F, Kumar V, Olson KE, Mosley RL, Gendelman HE
Clinical and translational medicine 2022 Jul;12(7):e958

Achyranthes bidentata Polysaccharide Activates Nuclear Factor-Kappa B and Promotes Cytokine Production in J774A.1 Cells Through TLR4/MyD88 Signaling Pathway.

Fan S, Wang Y, Zhang Y, Wu Y, Chen X
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TLR2 inhibition ameliorates the amplification effect of LPS on lipid accumulation and lipotoxicity in hepatic cells.

Zhang L, Xie Z, Yu H, Du H, Wang X, Cai J, Qiu Y, Chen R, Jiang X, Liu Z, Li Y, Chen T
Annals of translational medicine 2021 Sep;9(18):1429

Clostridium Butyricum ZJU-F1 Benefits the Intestinal Barrier Function and Immune Response Associated with Its Modulation of Gut Microbiota in Weaned Piglets.

Fu J, Wang T, Xiao X, Cheng Y, Wang F, Jin M, Wang Y, Zong X
Cells 2021 Mar 2;10(3)

Azilsartan Suppressed LPS-Induced Inflammation in U937 Macrophages through Suppressing Oxidative Stress and Inhibiting the TLR2/MyD88 Signal Pathway.

Dong Q, Li Y, Chen J, Wang N
ACS omega 2021 Jan 12;6(1):113-118

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