310812
antibody from BioLegend
Targeting: CD40LG
CD154, CD40L, gp39, hCD40L, HIGM1, IMD3, TNFSF5, TRAP
Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 310812 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#310812, RRID:AB_314835
- Product name
- LEAF™ anti-human CD154 [24-31]
- Antibody type
- Monoclonal
- Antigen
- CD154
- Description
- CD154 (CD40 ligand) is also known as CD40L, gp39, TRAP and T-BAM. CD40 ligand is a 32-39 kD type II transmembrane glycoprotein. It is a member of the TNF superfamily and is expressed on activated T cells. It has been reported to be important for B cell costimulation following binding of its receptor, CD40. Additionally, binding of CD40L to CD40 on B cells promotes the secretion of immunoglobulin and Ig isotype switching. CD40L is also involved in the regulation of cytokine production by T cells.
- Reactivity
- Human, Simian
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 500 µg
- Concentration
- 1 mg/ml
- Storage
- The CD154 antibody solution should be stored undiluted at 4 °C. This LEAF™ solution contains no preservative; handle under aseptic conditions.
Submitted references Polypyrimidine tract-binding protein is critical for the turnover and subcellular distribution of CD40 ligand mRNA in CD4+ T cells.
Natural killer cells trigger differentiation of monocytes into dendritic cells.
Matus-Nicodemos R, Vavassori S, Castro-Faix M, Valentin-Acevedo A, Singh K, Marcelli V, Covey LR
Journal of immunology (Baltimore, Md. : 1950) 2011 Feb 15;186(4):2164-71
Journal of immunology (Baltimore, Md. : 1950) 2011 Feb 15;186(4):2164-71
Natural killer cells trigger differentiation of monocytes into dendritic cells.
Zhang AL, Colmenero P, Purath U, Teixeira de Matos C, Hueber W, Klareskog L, Tarner IH, Engleman EG, Söderström K
Blood 2007 Oct 1;110(7):2484-93
Blood 2007 Oct 1;110(7):2484-93
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Supportive validation
- Submitted by
- BioLegend (provider)
- Main image
- Experimental details
- PMA+ionomycin-stimulated human PBMCs (6 hours) stained with 24-31 PE
- Conjugate
- Unconjugated