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- Antibody Data
- Antigen structure
- References [14]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 22456-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#22456-1-AP, RRID:AB_10918271
- Product name
- PKLR antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PKLR antibody (Cat. #22456-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Alpha-solanine Anti-tumor Effects in Non-small Cell Lung Cancer Through Regulating the Energy Metabolism Pathway.
Extracellular vesicle-mediated communication between hepatocytes and natural killer cells promotes hepatocellular tumorigenesis.
NLRP3 inflammasome blocked the glycolytic pathway via targeting to PKLR in arsenic-induced hepatic insulin resistance.
Loss of miR-23b/27b/24-1 Cluster Impairs Glucose Tolerance via Glycolysis Pathway in Mice.
Akt kinase LANCL2 functions as a key driver in EGFR-mutant lung adenocarcinoma tumorigenesis.
Multi-Tissue Acceleration of the Mitochondrial Phosphoenolpyruvate Cycle Improves Whole-Body Metabolic Health.
Apolipoprotein A-IV involves in glucose and lipid metabolism of rat.
The NQO1/PKLR axis promotes lymph node metastasis and breast cancer progression by modulating glycolytic reprogramming.
Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production.
Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction.
Role of AMPD2 in impaired glucose tolerance induced by high fructose diet.
Up-regulation of PKM2 promote malignancy and related to adverse prognostic risk factor in human gallbladder cancer.
Retinoic acid-related orphan receptor γ (RORγ): a novel participant in the diurnal regulation of hepatic gluconeogenesis and insulin sensitivity.
Influenza A virus-induced degradation of eukaryotic translation initiation factor 4B contributes to viral replication by suppressing IFITM3 protein expression.
Zou T, Gu L, Yang L, Wei J, Zhao Y, Shen J, Li M, Wu X, Du F, Chen Y, Ye Y, Xiao Z, Wu Z
Recent patents on anti-cancer drug discovery 2022;17(4):396-409
Recent patents on anti-cancer drug discovery 2022;17(4):396-409
Extracellular vesicle-mediated communication between hepatocytes and natural killer cells promotes hepatocellular tumorigenesis.
Liu Z, You Y, Chen Q, Li G, Pan W, Yang Q, Dong J, Wu Y, Bei JX, Pan C, Li F, Li B
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Feb 2;30(2):606-620
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Feb 2;30(2):606-620
NLRP3 inflammasome blocked the glycolytic pathway via targeting to PKLR in arsenic-induced hepatic insulin resistance.
Zhang J, Qiu T, Jiang L, Wang N, Zhu Y, Yan R, Wang S, Bai J, Shi X, Yang G, Liu X, Yao X, Sun X
Ecotoxicology and environmental safety 2021 Oct 15;223:112590
Ecotoxicology and environmental safety 2021 Oct 15;223:112590
Loss of miR-23b/27b/24-1 Cluster Impairs Glucose Tolerance via Glycolysis Pathway in Mice.
Jiang YH, Man YY, Liu Y, Yin CJ, Li JL, Shi HC, Zhao H, Zhao SG
International journal of molecular sciences 2021 Jan 7;22(2)
International journal of molecular sciences 2021 Jan 7;22(2)
Akt kinase LANCL2 functions as a key driver in EGFR-mutant lung adenocarcinoma tumorigenesis.
Lou Y, Xu J, Zhang Y, Zhang W, Zhang X, Gu P, Zhong H, Wang H, Lu J, Han B
Cell death & disease 2021 Feb 10;12(2):170
Cell death & disease 2021 Feb 10;12(2):170
Multi-Tissue Acceleration of the Mitochondrial Phosphoenolpyruvate Cycle Improves Whole-Body Metabolic Health.
Abulizi A, Cardone RL, Stark R, Lewandowski SL, Zhao X, Hillion J, Ma L, Sehgal R, Alves TC, Thomas C, Kung C, Wang B, Siebel S, Andrews ZB, Mason GF, Rinehart J, Merrins MJ, Kibbey RG
Cell metabolism 2020 Nov 3;32(5):751-766.e11
Cell metabolism 2020 Nov 3;32(5):751-766.e11
Apolipoprotein A-IV involves in glucose and lipid metabolism of rat.
Wang Z, Wang L, Zhang Z, Feng L, Song X, Wu J
Nutrition & metabolism 2019;16:41
Nutrition & metabolism 2019;16:41
The NQO1/PKLR axis promotes lymph node metastasis and breast cancer progression by modulating glycolytic reprogramming.
Yang Y, Zhu G, Dong B, Piao J, Chen L, Lin Z
Cancer letters 2019 Jul 1;453:170-183
Cancer letters 2019 Jul 1;453:170-183
Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production.
Gassaway BM, Cardone RL, Padyana AK, Petersen MC, Judd ET, Hayes S, Tong S, Barber KW, Apostolidi M, Abulizi A, Sheetz JB, Kshitiz, Aerni HR, Gross S, Kung C, Samuel VT, Shulman GI, Kibbey RG, Rinehart J
Cell reports 2019 Dec 10;29(11):3394-3404.e9
Cell reports 2019 Dec 10;29(11):3394-3404.e9
Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction.
Qi W, Keenan HA, Li Q, Ishikado A, Kannt A, Sadowski T, Yorek MA, Wu IH, Lockhart S, Coppey LJ, Pfenninger A, Liew CW, Qiang G, Burkart AM, Hastings S, Pober D, Cahill C, Niewczas MA, Israelsen WJ, Tinsley L, Stillman IE, Amenta PS, Feener EP, Vander Heiden MG, Stanton RC, King GL
Nature medicine 2017 Jun;23(6):753-762
Nature medicine 2017 Jun;23(6):753-762
Role of AMPD2 in impaired glucose tolerance induced by high fructose diet.
Hudoyo AW, Hirase T, Tandelillin A, Honda M, Shirai M, Cheng J, Morisaki H, Morisaki T
Molecular genetics and metabolism reports 2017 Dec;13:23-29
Molecular genetics and metabolism reports 2017 Dec;13:23-29
Up-regulation of PKM2 promote malignancy and related to adverse prognostic risk factor in human gallbladder cancer.
Lu W, Cao Y, Zhang Y, Li S, Gao J, Wang XA, Mu J, Hu YP, Jiang L, Dong P, Gong W, Liu Y
Scientific reports 2016 Jun 10;6:26351
Scientific reports 2016 Jun 10;6:26351
Retinoic acid-related orphan receptor γ (RORγ): a novel participant in the diurnal regulation of hepatic gluconeogenesis and insulin sensitivity.
Takeda Y, Kang HS, Freudenberg J, DeGraff LM, Jothi R, Jetten AM
PLoS genetics 2014;10(5):e1004331
PLoS genetics 2014;10(5):e1004331
Influenza A virus-induced degradation of eukaryotic translation initiation factor 4B contributes to viral replication by suppressing IFITM3 protein expression.
Wang S, Chi X, Wei H, Chen Y, Chen Z, Huang S, Chen JL
Journal of virology 2014 Aug;88(15):8375-85
Journal of virology 2014 Aug;88(15):8375-85
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- MCF7 cells were subjected to SDS PAGE followed by western blot with 22456-1-AP(PKLR antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PKLR antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human PKLR. This antibody recognizes human,mouse,rat antigen. The PKLR antibody has been validated for the following applications: ELISA, WB, IHC analysis.
