DCAB-TJ026

antibody from Creative Diagnostics

Targeting: S100A1 S100-alpha, S100A

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

DCAB-TJ026

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DCAB-TJ026, RRID:AB_2489788

Product name

Anti-S-100 Protein monoclonal antibody, clone T200 328

Antibody type

Monoclonal

Description

S100 protein is a type of low molecular weight protein found in vertebrates characterized by two calcium binding sites of the helix-loop-helix ("EF-hand type") conformation. There are at least 21 different types of S100 proteins. The name is derived from the fact that the protein is 100% Soluble in ammonium sulfate at neutral pH. Most S100 proteins are homodimeric, consisting of two identical polypeptides held together by non-covalent bonds. S100A is composed of an alpha and beta chain whereas S100B is composed of two beta chains. Although S100 proteins are structurally similar to calmodulin, they differ in that they are cell-specific, expressed in particular cells at different levels depending on environmental factors. To contrast, calmodulin is a ubiquitous and universal intracellular Ca++ receptor widely expressed in many cells. S-100 is normally present in cells derived from the neural crest (Schwann cells, melanocytes, and glia cells), chondrocyte, adipocytes, myoepithelial cells, macrophages, Langerhans cells, dendritic cells, and keratinocytes. It may be present in some breast epithelial cells.

Reactivity

Bovine

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

T200 328

Vial size

7.0 ml

Concentration

5.0 Ã×g/ml

Storage

2-8°C