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Learn10298-1-AP
antibody from Proteintech Group
Targeting: LMNA
CMD1A, HGPS, LGMD1B, LMN1, LMNL1, MADA, PRO1
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [322]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
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- Product number
- 10298-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10298-1-AP, RRID:AB_2296961
- Product name
- Lamin A/C antibody
- Antibody type
- Polyclonal
- Description
- Lamin A/C antibody (Cat. #10298-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 150ul
Submitted references TL1A serves as a positive regulator to promote adipocyte differentiation.
LBR and LAP2 mediate heterochromatin tethering to the nuclear periphery to preserve genome homeostasis.
The natural flavonoid dihydromyricetin targets senescent cells via PRDX2 and alleviates age-related diseases.
Downregulation of TDP43 by atovaquone inhibits oxidative phosphorylation and enhances sensitivity of triple-negative breast cancer to EGFR-TKIs.
Gypenoside L inhibits oral squamous cell carcinoma progression by targeting the AKT signaling pathway.
Shikonin improves intestinal barrier function through modulation of GPX4 expression in intestinal epithelial cells.
KIF2A-mediated microtubule-dependent nuclear envelope invagination drives nonhomologous end joining.
UBC9-mediated regulation of K144 ubiquitination of Lamin A and its implications for hepatocellular carcinoma.
DNA damage in macrophages drives immune autoreactivity via nuclear antigen presentation.
Gastrodin alleviates alcohol-induced developmental and neurotoxic effects in zebrafish larvae by suppressing ferroptosis via regulating the Nrf2/GPX4 signaling pathway.
Ezetimibe attenuates diabetic retinopathy via NRF2-mediated suppression of inflammation and oxidative stress.
Rabeprazole attenuates fibrosis by modulating SMAD3 linker region phosphorylation.
Aronia Berry Extract Inhibits Cancer Stemness and Overcomes 5-Fluorouracil Resistance by Targeting TLR3/NF-κB Signaling in Colorectal Cancer.
Enolase 1 suppresses influenza A virus replication by blocking the nuclear import of the viral ribonucleoprotein complex.
Research on the mechanism of CRMP4-mediated cytoskeletal actin polymerization in promoting invasive migration of stromal cells in endometriosis.
A human patient-derived organoid biobank to model tumor heterogeneity and therapeutic vulnerability for oral squamous cell carcinoma.
Computational-experimental integration reveals PPARγ/Nrf2-GPX4 dual-targeting by combined selenomethionine-magnolol as a novel therapy for sarcopenic obesity.
FKBP10 Promotes the Muscle Invasion of Bladder Cancer via Lamin A Dysregulation.
Silencing NRF2 enhances arsenic trioxide-induced ferroptosis in hepatocellular carcinoma cells.
Hepatic ASPG-mediated lysophosphatidylinositol catabolism impairs insulin signal transduction.
Glutaredoxin 1 enhances endothelial cell angiogenesis by reducing VEGFA S-glutathionylation and delays vascular endothelial cell senescence.
Nuclear force transmission drives cancer-associated fibroblast activation under BRAF inhibition.
Kuwanon A Targeted YWHAB in Hepatocellular Carcinoma Cells to Inhibit the Raf/MEK/ERK Signaling Pathway.
Oxidative stress-induced ZEB1 acetylation drives a hybrid epithelial-mesenchymal phenotype and promotes lung metastasis in triple-negative breast cancer.
Novel LBR pathogenic variants with loss of sterol reductase activity participate in the pathogenesis of skeletal dysplasia via dysregulating canonical Wnt pathway.
PPP1CA promotes hepatocellular carcinoma progression in a YAP1-dependent way.
The deubiquitination enzyme USP14 promotes the tumourigenesis of gastric cancer by enhancing c-MYC nuclear translocation through deubiquitination of KPNA2.
TRAP1 inhibits KANSL3 acetylation to alleviate mitochondrial dysfunction by promoting mitophagy in cardiomyocytes under diabetic conditions.
Centromere protein I facilitates breast cancer tumorigenesis and disease progression through modulation of Wnt/β-Catenin signaling.
KSRP-mediated Wnt/β-catenin activation promotes follicular thyroid cancer progression and stemness.
Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels.
A nucleoskeleton network preserves genomic integrity by promoting NHEJ and restraining chromosome translocations.
RBMX2 links Mycobacterium bovis infection to epithelial-mesenchymal transition and lung cancer progression.
The Wnt/APC destruction complex targets SREBP2 in a β-catenin-independent pathway to control cholesterol metabolism.
PNMA4 enhances anti-RNA virus immunity by promoting RIG-I signaling pathway.
NFAT2 Induces Tumor Cell Proliferation and Metastasis by Acting as a Transcriptional Co-activator of the TGF-β1/SMAD Signaling Pathway and Inducing the Epithelial-Mesenchymal Transition in Liver Cancer.
Epithelial-Mesenchymal Plasticity in the D-Meso-Sonobe Mesothelioma Cell Line: A Putative Model of Epithelial-Mesenchymal Transition in Mesothelioma.
Bicuculline ameliorates metabolic dysfunction-associated steatotic liver disease by inhibiting the nuclear factor-kappa B pathway and reducing lipid accumulation.
THG-1/TSC22D4 Promotes IL-1 Signaling through Stabilization of TRAF6 in Squamous Cell Carcinoma.
Dietary coconut oil lowered circulating fetuin-A levels and hepatic expression of fetuin-A in KK/TaJcl mice.
Chlorophyllides repress gain-of-function p53 mutated HNSCC cell proliferation via activation of p73 and repression of p53 aggregation in vitro and in vivo.
ASPM mediates nuclear entrapment of FOXM1 via liquid-liquid phase separation to promote progression of hepatocarcinoma.
PKM2 knockout facilitates the activation of the AMPK/KLF4/ACADVL pathway, leading to increased oxidative degradation of fatty acids in TNBC.
Activation of megakaryocytic leukemia 1 in endothelial cells contributes to diabetic retinopathy in mice.
Delivery of LOXL1-AS1-siRNAs using targeting peptide-engineered extracellular vesicles with focused ultrasound to suppress medulloblastoma metastasis.
Fatty Acid Desaturase 1 Knockdown Promotes Wound Healing and Functional Recovery of the Corneal Epithelium in Diabetes.
E2-Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells.
Adducin-1 Facilitates Influenza Virus Endosomal Trafficking and Uncoating by Regulating Branched Actin Dynamics and Myosin IIB Activity.
Paeonol ameliorates diabetic nephropathy by promoting TFEB-mediated lysosome biogenesis and lipophagy.
The important role of the Wnt/β-catenin signaling pathway in small molecules mediated gingival mesenchymal stem cells transdifferentiate into neuron-like cells.
Inhibiting intracellular CD28 in cancer cells enhances antitumor immunity and overcomes anti-PD-1 resistance via targeting PD-L1.
Clinical Significance of Acyl-CoA Dehydrogenase Short Chain and Its Anti-tumor Role in Hepatocellular Carcinoma by Inhibiting Canonical Wnt/β-Catenin Pathway.
Engineered protein G variants for multifunctional antibody-based assemblies.
ZDHHC3-LYPLA1 regulates PRRSV-2 replication through reversible palmitoylation.
Mechanical Force-Induced cGAS Activation in Carcinoma Cells Facilitates Splenocytes into Liver to Drive Metastasis.
Clofarabine induces tumor cell apoptosis, GSDME-related pyroptosis, and CD8(+) T-cell antitumor activity via the non-canonical P53/STING pathway.
FAM210B activates STAT1/IRF9/IFIT3 axis by upregulating IFN-α/β expression to impede the progression of lung adenocarcinoma.
Nucleolar NOL9 regulated by DNA methylation promotes hepatocellular carcinoma growth through activation of Wnt/β-catenin signaling pathway.
ATR-hippo drives force signaling to nuclear F-actin and links mechanotransduction to neurological disorders.
Propofol inhibits glioma growth by blocking the formation of the NF-κB/LGI4 feedback loop to activate TP53 self-transcription.
Mechanotransduction Mediated by PDLIM5: The Critical Role of Serpin E2/Integrin β3-Cytoskeleton-Nucleoskeleton Axis in Mechanical Osteogenic Programming.
Integrative single-cell and spatial transcriptome analysis reveals the functions of TREM2(high) macrophages and infarct border dynamics post-myocardial infarction.
Dual-wavelength UV photofunctionalization of 3D-printed Ti6Al4V porous bone implant enhances osseointegration via adhesion-cytoskeleton-nuclear mechanotransduction.
miR-140-5p Overexpression Contributes to Oxidative Stress and Mitochondrial Dysfunction in Hutchinson-Gilford Progeria Syndrome Fibroblasts Through NRF2 Pathway.
ALFA nanobody-guided endogenous labeling.
SerpinA3N-APOE interaction in astrocytes exacerbates Alzheimer's disease progression through NFκB activation.
SREBP1-mediated lipogenesis promotes dedifferentiation and senescence of vascular smooth muscle cells through epigenetic remodeling.
Resveratrol Prevents Breast Cancer Metastasis by Inhibiting Wnt/β-Catenin Pathway-Mediated Epithelial-Mesenchymal Transition.
Cytomegalovirus disrupts Lamin A/C to control microtubule-mediated nuclear movement and cell migration.
P2X7-CaMKII drives 5-LOX nuclear translocation to impair microglial function after subarachnoid hemorrhage.
PAD2 disturbs cardiomyocyte calcium homeostasis by citrullinating SERCA2a protein in hemorrhagic shock induced arrhythmia.
Subcellular proteomics reveals the crosstalk between nucleocytoplasmic trafficking and the innate immune response to Senecavirus A infection.
CRM1 mediates ASC nuclear export and inflammasome activation.
PRMT5-mediated methylation of METTL3 promotes cisplatin resistance in ovarian cancer by facilitating DNA repair mechanisms.
Macropinocytosis regulates cytokine expression through Erk signaling in LPS-stimulated macrophages.
Hepatitis B surface antigen hijacks TANK-binding kinase 1 to suppress type I interferon and induce early autophagy.
The LysoPS/GPR174 axis drives metastatic progression in esophageal squamous cell carcinoma through cAMP-PKA-CREB signaling activation.
Sorbitol Destroyed Intestinal Microfold Cells (M Cells) Development through Inhibition of PDE4-Mediated RANKL Expression.
Conditioned Medium Derived From Human Dental Follicle Mesenchymal Stem Cells Alleviates Macrophage Proinflammatory Responses Through MAPK-ERK-EGR1 Axis.
TGFβ1-Induced Fibrotic Responses of Conjunctival Fibroblasts through the Wnt/β-Catenin/CRYAB Signaling Pathway.
GRP75 triggers white adipose tissue browning to promote cancer-associated cachexia.
Nogo-B inhibition facilitates cholesterol metabolism to reduce hypercholesterolemia.
Zinc-finger CCHC-type containing protein 8 promotes RNA virus replication by suppressing the type-I interferon responses.
Sirt2 Regulates Liver Metabolism in a Sex-Specific Manner.
Identification of a novel caspase cleavage motif AEAD.
The syntaxin-binding protein STXBP5 regulates progerin expression.
Epigenetic Regulation of CXC Chemokine Expression by Environmental Electrophiles Through DNA Methyltransferase Inhibition.
Macropinocytic cups function as signal platforms for the mTORC2-AKT pathway to modulate LPS-induced cytokine expression in macrophages.
SUN2 mediates calcium-triggered nuclear actin polymerization to cluster active RNA polymerase II.
USP2 Mitigates Reactive Oxygen Species-Induced Mitochondrial Damage via UCP2 Expression in Myoblasts.
EHD1 promotes breast cancer metastasis through upregulating HIF2a expression via activating mTOR pathway.
Excessive linoleic acid induces muscle oxidative stress through 5-lipoxygenase-dependent peroxidation.
UBC9-mediated SUMOylation of Lamin B1 enhances DNA-damage-induced nuclear DNA leakage and autophagy after spinal cord injury.
Genetic and pharmacological modulation of lamin A farnesylation determines its function and turnover.
N6-Methyladenosine Modification of lncCCKAR-5 Regulates Autophagy in Human Umbilical Cord Mesenchymal Stem Cells by Destabilizing LMNA and Inhibits Diabetic Wound Healing.
SETDB1 modulates the TGFβ response in Duchenne muscular dystrophy myotubes.
P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting p-tau217 with immunotherapy ameliorates murine tauopathy.
Chicken UFL1 Restricts Avian Influenza Virus Replication by Disrupting the Viral Polymerase Complex and Facilitating Type I IFN Production.
Nuclear SphK2/S1P signaling is a key regulator of ApoE production and Aβ uptake in astrocytes.
MaiJiTong granule attenuates atherosclerosis by reducing ferroptosis via activating STAT6-mediated inhibition of DMT1 and SOCS1/p53 pathways in LDLR(-/-) mice.
Protocol for isolating small cytosolic dsDNA from cultured murine cells.
Cell surface CD55 traffics to the nucleus leading to cisplatin resistance and stemness by inducing PRC2 and H3K27 trimethylation on chromatin in ovarian cancer.
Overexpression of FHL1 suppresses papillary thyroid cancer proliferation and progression via inhibiting Wnt/β-catenin pathway.
Aronia Berry Extract Modulates MYD88/NF-kB/P-Glycoprotein Axis to Overcome Gemcitabine Resistance in Pancreatic Cancer.
Nuclear translocation of ISG15 regulated by PPP2R2B inhibits cisplatin resistance of bladder cancer.
Eukaryotic AlaX provides multiple checkpoints for quality and quantity of aminoacyl-tRNAs in translation.
The effect of overexpression of CyPA on gene expression in human umbilical vein endothelial cells.
The dual role of FSP1 in programmed cell death: resisting ferroptosis in the cell membrane and promoting necroptosis in the nucleus of THP-1 cells.
Sanguinarine Induces Necroptosis of HCC by Targeting PKM2 Mediated Energy Metabolism.
GRK5 promoted renal fibrosis via HDAC5/Smad3 signaling pathway.
Targeting NANOG and FAK via Cx26-derived Cell-penetrating Peptides in Triple-negative Breast Cancer.
TMEM216 promotes primary ciliogenesis and Hedgehog signaling through the SUFU-GLI2/GLI3 axis.
TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis.
Prothymosin α accelerates dengue virus-induced thrombocytopenia.
c-Fos regulated by TMPO/ERK axis promotes 5-FU resistance via inducing NANOG transcription in colon cancer.
The novel mechanism of human norovirus induced diarrhea: Activation of PKD2 caused by HuNoVs destroyed AQP3 expression through AP2γ in intestinal epithelial cells.
p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson-Gilford progeria syndrome.
Sodium butyrate alleviates lead-induced neuroinflammation and improves cognitive and memory impairment through the ACSS2/H3K9ac/BDNF pathway.
IL-8 activates fibroblasts to promote the invasion of HNSCC cells via STAT3-MMP1.
Cepharanthine suppresses APC-mutant colorectal cancers by down-regulating the expression of β-catenin.
Viral N protein hijacks deaminase-containing RNA granules to enhance SARS-CoV-2 mutagenesis.
The plant extract PNS mitigates atherosclerosis via promoting Nrf2-mediated inhibition of ferroptosis through reducing USP2-mediated Keap1 deubiquitination.
PRMT1-mediated arginine methylation promotes YAP activation and hepatocellular carcinoma proliferation.
Spatial organizations of heterochromatin underpin nuclear structural integrity of ventricular cardiomyocytes against mechanical stress.
Exosome-delivered NR2F1-AS1 and NR2F1 drive phenotypic transition from dormancy to proliferation in treatment-resistant prostate cancer via stabilizing hormonal receptors.
In vitro and in vivo inhibition of the host TRPC4 channel attenuates Zika virus infection.
The Compromised Fanconi Anemia Pathway in Prelamin A-Expressing Cells Contributes to Replication Stress-Induced Genomic Instability.
(CG)-SLENP: A Chemical Genetics Strategy To Selectively Label Existing Proteins and Newly Synthesized Proteins.
Ferritin heavy chain supports stability and function of the regulatory T cell lineage.
Defective prelamin A processing promotes unconventional necroptosis driven by nuclear RIPK1.
Liver ChREBP deficiency inhibits fructose-induced insulin resistance in pregnant mice and female offspring.
Nuclear deformation and cell division of single cell on elongated micropatterned substrates fabricated by DMD lithography.
Neutrophils secrete exosome-associated DNA to resolve sterile acute inflammation.
DCDC2 inhibits hepatic stellate cell activation and ameliorates CCl(4)-induced liver fibrosis by suppressing Wnt/β-catenin signaling.
MAVS promotes interferon signaling in RNA virus infection by ZUFSP-mediated chromatin regulation.
GRAS1 non-coding RNA protects against DNA damage and cell death by binding and stabilizing NKAP.
Whole exome sequencing reveals novel variants associated with diminished ovarian reserve in young women.
Lycium barbarum polysaccharide alleviates dextran sodium sulfate-induced inflammatory bowel disease by regulating M1/M2 macrophage polarization via the STAT1 and STAT6 pathways.
High expression of peroxisomal D-bifunctional protein in cytosol regulates apoptosis and energy metabolism of hepatocellular carcinoma cells via PI3K/AKT pathway.
Integrative proteomics highlight presynaptic alterations and c-Jun misactivation as convergent pathomechanisms in ALS.
Oridonin inhibits the occurrence and development of colorectal cancer by reversing the Warburg effect via reducing PKM2 dimer formation and preventing its entry into the nucleus.
Optineurin tunes outside-in signaling to regulate lysosome biogenesis and phagocytic clearance in the retina.
Mongolian medicine Wenguanmu ointment treats eczema by inhibiting the CKLF-1/NF-κB pathway.
FN1 mediated activation of aspartate metabolism promotes the progression of triple-negative and luminal a breast cancer.
KIAA1429/VIRMA promotes breast cancer progression by m(6) A-dependent cytosolic HAS2 stabilization.
Prohibitin1 facilitates viral replication by impairing the RIG-I-like receptor signaling pathway.
Heat shock protein DNAJA2 regulates transcription-coupled repair by triggering CSB degradation via chaperone-mediated autophagy.
Enamel defects of Axenfeld-Rieger syndrome and the role of PITX2 in its pathogenesis.
The poxvirus F17 protein counteracts mitochondrially orchestrated antiviral responses.
Morusinol Extracted from Morus alba Inhibits Cell Proliferation and Induces Autophagy via FOXO3a Nuclear Accumulation-Mediated Cholesterol Biosynthesis Obstruction in Colorectal Cancer.
NamiRNA-enhancer network of miR-492 activates the NR2C1-TGF-β/Smad3 pathway to promote epithelial-mesenchymal transition of pancreatic cancer.
Nogo-B deficiency suppresses white adipogenesis by regulating β-catenin signaling.
The well-developed actin cytoskeleton and Cthrc1 expression by actin-binding protein drebrin in myofibroblasts promote cardiac and hepatic fibrosis.
SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes.
Erxian decoction alleviates cisplatin-induced premature ovarian failure in rats by reducing oxidation levels in ovarian granulosa cells.
Proliferating cell nuclear antigen impairs the nuclear import of influenza A virus PB2 and suppresses virus replication.
LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer.
USP28 controls SREBP2 and the mevalonate pathway to drive tumour growth in squamous cancer.
LAP1 supports nuclear adaptability during constrained melanoma cell migration and invasion.
Alternative transcribed 3' isoform of long non-coding RNA Malat1 inhibits mouse retinal oxidative stress.
Cerium Oxide Nanoparticles Promote Osteoplastic Precursor Differentiation by Activating the Wnt Pathway.
Characterization of huntingtin interactomes and their dynamic responses in living cells by proximity proteomics.
Upregulation of autotaxin by oxidative stress via Nrf2 activation: A novel insight into the compensation mechanism in preeclamptic placenta.
FHL2 Inhibits SARS-CoV-2 Replication by Enhancing IFN-β Expression through Regulating IRF-3.
High-Throughput, Low Background, and Wide-Field Microscopy by Flat-Field Photobleaching Imprinting Microscopy.
ROR1/STAT3 positive feedback loop facilitates cartilage degeneration in Osteoarthritis through activation of NF-κB signaling pathway.
A Novel Transgenic Mouse Model Implicates Sirt2 as a Promoter of Hepatocellular Carcinoma.
An oncogenic isoform of septin 9 promotes the formation of juxtanuclear invadopodia by reducing nuclear deformability.
XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility.
A small-molecule inhibitor of Keap1-Nrf2 interaction attenuates sepsis by selectively augmenting the antibacterial defence of macrophages at infection sites.
HnRNP K reduces viral gene expression by targeting cytosine-rich sequences in porcine reproductive and respiratory syndrome virus-2 genome to dampen the viral growth.
E2F1-mediated ectopic expression of PP1A promotes breast cancer progression via activation of YAP1.
ZSWIM1 Promotes the Proliferation and Metastasis of Lung Adenocarcinoma Cells through the STK38/MEKK2/ERK1/2 Axis.
CircRNF10-DHX15 interaction suppressed breast cancer progression by antagonizing DHX15-NF-κB p65 positive feedback loop.
Progerinin, an Inhibitor of Progerin, Alleviates Cardiac Abnormalities in a Model Mouse of Hutchinson-Gilford Progeria Syndrome.
Metabolomics of clinical samples reveal the treatment mechanism of lanthanum hydroxide on vascular calcification in chronic kidney disease.
Caspase-1-mediated extracellular vesicles derived from pyroptotic alveolar macrophages promote inflammation in acute lung injury.
Mouse Ocilrp2/Clec2i negatively regulates LPS-mediated IL-6 production by blocking Dap12-Syk interaction in macrophage.
Metformin Ameliorates Chronic Colitis-Related Intestinal Fibrosis via Inhibiting TGF-β1/Smad3 Signaling.
Suberoylanilide Hydroxamic Acid (SAHA) Treatment Reveals Crosstalk Among Proteome, Phosphoproteome, and Acetylome in Nasopharyngeal Carcinoma Cells.
Keratin 17 Promotes T Cell Response in Allergic Contact Dermatitis by Upregulating C-C Motif Chemokine Ligand 20.
Nrf2 Overexpression Decreases Vincristine Chemotherapy Sensitivity Through the PI3K-AKT Pathway in Adult B-Cell Acute Lymphoblastic Leukemia.
AKR1B10 accelerates the production of proinflammatory cytokines via the NF-κB signaling pathway in colon cancer.
Deletion of Smurf1 attenuates liver steatosis via stabilization of p53.
Synaptic proteomics reveal distinct molecular signatures of cognitive change and C9ORF72 repeat expansion in the human ALS cortex.
MCM2 promotes the stemness and sorafenib resistance of hepatocellular carcinoma cells via hippo signaling.
Targeting epiregulin in the treatment-damaged tumor microenvironment restrains therapeutic resistance.
Disturbing NLRP3 acetylation and inflammasome assembly inhibits androgen receptor-promoted inflammatory responses and prostate cancer progression.
Olfactory marker protein contains a leucine-rich domain in the Ω-loop important for nuclear export.
Activation of Nrf2 modulates protective immunity against Mycobacterium tuberculosis infection in THP1-derived macrophages.
SETDB1 fuels the lung cancer phenotype by modulating epigenome, 3D genome organization and chromatin mechanical properties.
Lactylation-driven METTL3-mediated RNA m(6)A modification promotes immunosuppression of tumor-infiltrating myeloid cells.
Cell-Penetrating Peptide TAT-HuR-HNS3 Suppresses Proinflammatory Gene Expression via Competitively Blocking Interaction of HuR with Its Partners.
Highly efficient A-to-G base editing by ABE8.17 in rabbits.
p62 Promotes the Mitochondrial Localization of p53 through Its UBA Domain and Participates in Regulating the Sensitivity of Ovarian Cancer Cells to Cisplatin.
Rapid and robust derivation of mesenchymal stem cells from human pluripotent stem cells via temporal induction of neuralized ectoderm.
Multiple PDE3A modulators act as molecular glues promoting PDE3A-SLFN12 interaction and induce SLFN12 dephosphorylation and cell death.
Loss of perinuclear theca ACTRT1 causes acrosome detachment and severe male subfertility in mice.
The perinuclear theca protein Calicin helps shape the sperm head and maintain the nuclear structure in mice.
A novel homozygous missense mutation in AK7 causes multiple morphological anomalies of the flagella and oligoasthenoteratozoospermia.
MITF activity is regulated by a direct interaction with RAF proteins in melanoma cells.
Static Magnetic Fields Reduce Oxidative Stress to Improve Wound Healing and Alleviate Diabetic Complications.
RICH1 inhibits breast cancer stem cell traits through activating kinases cascade of Hippo signaling by competing with Merlin for binding to Amot-p80.
Inhibition of high-fat diet-induced obesity via reduction of ER-resident protein Nogo occurs through multiple mechanisms.
Novel Mutation and Deletion in SUN5 Cause Male Infertility with Acephalic Spermatozoa Syndrome.
Inhibition of FOXO1‑mediated autophagy promotes paclitaxel‑induced apoptosis of MDA‑MB‑231 cells.
HDAC9 Contributes to Serous Ovarian Cancer Progression through Regulating Epithelial-Mesenchymal Transition.
miR-376a-3p and miR-376b-3p overexpression in Hutchinson-Gilford progeria fibroblasts inhibits cell proliferation and induces premature senescence.
Substrate rigidity dictates colorectal tumorigenic cell stemness and metastasis via CRAD-dependent mechanotransduction.
Qushi Huayu decoction attenuated hepatic lipid accumulation via JAK2/STAT3/CPT-1A-related fatty acid β-oxidation in mice with non-alcoholic steatohepatitis.
Loss of Mature Lamin A/C Triggers a Shift in Intracellular Metabolic Homeostasis via AMPKα Activation.
Tetrahydroxy Stilbene Glucoside Alleviates Ischemic Stroke by Regulating Conformation-Dependent Intracellular Distribution of PKM2 for M2 Macrophage Polarization.
Hsa_circ_0005050 interacts with ILF3 and affects cell apoptosis and proliferation by disrupting the balance between p53 and p65.
Lanthanum hydroxide inhibits vascular calcification by regulating the HIF-1 pathway.
Irradiation combined with PD-L1(-/-) and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING-mediated T cell activation.
Global crotonylome reveals hypoxia-mediated lamin A crotonylation regulated by HDAC6 in liver cancer.
BRCA2 promoter hypermethylation as a biomarker for the leukemic transformation of myeloproliferative neoplasms.
The Pharmacological Effect and Mechanism of Lanthanum Hydroxide on Vascular Calcification Caused by Chronic Renal Failure Hyperphosphatemia.
Folic Acid Protects Melanocytes from Oxidative Stress via Activation of Nrf2 and Inhibition of HMGB1.
Hepatitis B Surface Antigen Suppresses the Activation of Nuclear Factor Kappa B Pathway via Interaction With the TAK1-TAB2 Complex.
Autophagy-Induced HDAC6 Activity During Hypoxia Regulates Mitochondrial Energy Metabolism Through the β-Catenin/COUP-TFII Axis in Hepatocellular Carcinoma Cells.
miR-1258 Attenuates Tumorigenesis Through Targeting E2F1 to Inhibit PCNA and MMP2 Transcription in Glioblastoma.
Adipocyte-Specific Deletion of Lamin A/C Largely Models Human Familial Partial Lipodystrophy Type 2.
Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing.
Long non-coding RNA NR2F1-AS1 induces breast cancer lung metastatic dormancy by regulating NR2F1 and ΔNp63.
The Retinoblastoma Tumor Suppressor Is Required for the NUP98-HOXA9-Induced Aberrant Nuclear Envelope Phenotype.
Bortezomib potentiates antitumor activity of mitoxantrone through dampening Wnt/β-catenin signal pathway in prostate cancer cells.
Arsenic trioxide induces expression of BCL-2 expression via NF-κB and p38 MAPK signaling pathways in BEAS-2B cells during apoptosis.
HSD17B6 downregulation predicts poor prognosis and drives tumor progression via activating Akt signaling pathway in lung adenocarcinoma.
The miR-378c-Samd1 circuit promotes phenotypic modulation of vascular smooth muscle cells and foam cells formation in atherosclerosis lesions.
The role of LR-TIMAP/PP1c complex in the occurrence and development of no-reflow.
EEF1A2 interacts with HSP90AB1 to promote lung adenocarcinoma metastasis via enhancing TGF-β/SMAD signalling.
Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway.
Virus-inducible IGFALS facilitates innate immune responses by mediating IRAK1 and TRAF6 activation.
Formin-like protein 2 promotes cell proliferation by a p27-related mechanism in human breast cancer cells.
Inducible ATP1B1 Upregulates Antiviral Innate Immune Responses by the Ubiquitination of TRAF3 and TRAF6.
Cryptotanshinone, a novel PDK 4 inhibitor, suppresses bladder cancer cell invasiveness via the mTOR/β‑catenin/N‑cadherin axis.
Cimigenoside functions as a novel γ-secretase inhibitor and inhibits the proliferation or metastasis of human breast cancer cells by γ-secretase/Notch axis.
Role of IL-6-IL-27 Complex in Host Antiviral Immune Response.
Nuclear Factor-κB Signaling Mediates Antimony-induced Astrocyte Activation.
Hsa_circ_0005273 facilitates breast cancer tumorigenesis by regulating YAP1-hippo signaling pathway.
Syndecan 4 contributes to osteoclast differentiation induced by RANKL through enhancing autophagy.
Carnosic acid protects against ferroptosis in PC12 cells exposed to erastin through activation of Nrf2 pathway.
Prenylated xanthones from mangosteen (Garcinia mangostana) activate the AhR and Nrf2 pathways and protect intestinal barrier integrity in HT-29 cells.
The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice.
hsa_circ_0068631 promotes breast cancer progression through c-Myc by binding to EIF4A3.
Ferroptosis inducer erastin sensitizes NSCLC cells to celastrol through activation of the ROS-mitochondrial fission-mitophagy axis.
AKR1B10 negatively regulates autophagy through reducing GAPDH upon glucose starvation in colon cancer.
Epiregulin (EREG) and Myocardin Related Transcription Factor A (MRTF-A) Form a Feedforward Loop to Drive Hepatic Stellate Cell Activation.
Heme Oxygenase-1 Suppresses Wnt Signaling Pathway in Nonalcoholic Steatohepatitis-Related Liver Fibrosis.
Single-cell RNA-sequencing analysis identifies host long noncoding RNA MAMDC2-AS1 as a co-factor for HSV-1 nuclear transport.
Hepatitis B Core Antigen Impairs the Polarization While Promoting the Production of Inflammatory Cytokines of M2 Macrophages via the TLR2 Pathway.
Nuclear pore blockade reveals that HIV-1 completes reverse transcription and uncoating in the nucleus.
TL1A inhibits atherosclerosis in apoE-deficient mice by regulating the phenotype of vascular smooth muscle cells.
Inhibition of protein phosphatase methylesterase 1 dysregulates MAP kinase signaling and attenuates muscle cell differentiation.
p62/SQSTM1 accumulation due to degradation inhibition and transcriptional activation plays a critical role in silica nanoparticle-induced airway inflammation via NF-κB activation.
Osteopetrosis-Associated Transmembrane Protein 1 Recruits RNA Exosome To Restrict Hepatitis B Virus Replication.
Overexpression of NRF1-742 or NRF1-772 Reduces Arsenic-Induced Cytotoxicity and Apoptosis in Human HaCaT Keratinocytes.
Cytoplasmic PCNA is located in the actin belt and involved in osteoclast differentiation.
α-Ketoglutarate Modulates Macrophage Polarization Through Regulation of PPARγ Transcription and mTORC1/p70S6K Pathway to Ameliorate ALI/ARDS.
Translation Efficiency and Degradation of ER-Associated mRNAs Modulated by ER-Anchored poly(A)-Specific Ribonuclease (PARN).
Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis.
SSEA3 and Sialyl Lewis a Glycan Expression Is Controlled by B3GALT5 LTR through Lamin A-NFYA and SIRT1-STAT3 Signaling in Human ES Cells.
LL-37 restored glucocorticoid sensitivity impaired by virus dsRNA in lung.
Tissue-Resident Alveolar Macrophages Do Not Rely on Glycolysis for LPS-induced Inflammation.
SOX2 Represses Hepatitis B Virus Replication by Binding to the Viral EnhII/Cp and Inhibiting the Promoter Activation.
N-myc downstream-regulated gene 2 promotes the protein stability of estrogen receptor beta via inhibition of ubiquitin-protein ligase E3A to suppress colorectal cancer.
SARS-CoV-2 Nucleocapsid Protein Interacts with RIG-I and Represses RIG-Mediated IFN-β Production.
Eukaryotic Translation Elongation Factor 1 Delta Inhibits the Nuclear Import of the Nucleoprotein and PA-PB1 Heterodimer of Influenza A Virus.
Torsin ATPases influence chromatin interaction of the Torsin regulator LAP1.
Interplay of m(6)A and H3K27 trimethylation restrains inflammation during bacterial infection.
Effects of mevalonate kinase interference on cell differentiation, apoptosis, prenylation and geranylgeranylation of human keratinocytes are attenuated by farnesyl pyrophosphate or geranylgeranyl pyrophosphate.
HuR stabilizes HTT mRNA via interacting with its exon 11 in a mutant HTT-dependent manner.
The CDK inhibitor p57(Kip2) enhances the activity of the transcriptional coactivator FHL2.
MiR-27a-regulated FOXO1 promotes pancreatic ductal adenocarcinoma cell progression by enhancing Wnt/β-catenin signaling activity.
Inhibition of Influenza A Virus Replication by TRIM14 via Its Multifaceted Protein-Protein Interaction With NP.
miR‑494‑3p regulates lipopolysaccharide‑induced inflammatory responses in RAW264.7 cells by targeting PTEN.
PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma.
Lamin A mutation impairs interaction with nucleoporin NUP155 and disrupts nucleocytoplasmic transport in atrial fibrillation.
Deficiency of heat shock protein A12A promotes browning of white adipose tissues in mice.
YAP mediates the positive regulation of hnRNPK on the lung adenocarcinoma H1299 cell growth.
JNK activation-mediated nuclear SIRT1 protein suppression contributes to silica nanoparticle-induced pulmonary damage via p53 acetylation and cytoplasmic localisation.
HSPA12A Is a Novel Player in Nonalcoholic Steatohepatitis via Promoting Nuclear PKM2-Mediated M1 Macrophage Polarization.
Matrix stiffness mediates stemness characteristics via activating the Yes-associated protein in colorectal cancer cells.
Angiomotin-p130 inhibits β-catenin stability by competing with Axin for binding to tankyrase in breast cancer.
HSF1 phosphorylation by cyclosporin A confers hyperthermia sensitivity through suppression of HSP expression.
Inducible LGALS3BP/90K activates antiviral innate immune responses by targeting TRAF6 and TRAF3 complex.
CRABP2 regulates invasion and metastasis of breast cancer through hippo pathway dependent on ER status.
NAC1 Potentiates Cellular Antiviral Signaling by Bridging MAVS and TBK1.
SKP2 Promotes Hepatocellular Carcinoma Progression Through Nuclear AMPK-SKP2-CARM1 Signaling Transcriptionally Regulating Nutrient-Deprived Autophagy Induction.
LOXL1 regulates cell apoptosis and migration in human neuroglioma U87 and U251 cells via Wnt/β-catenin signaling.
Calycosin alleviates allergic contact dermatitis by repairing epithelial tight junctions via down-regulating HIF-1α.
Role of c-Abl-GSK3β Signaling in MPP+-Induced Autophagy-Lysosomal Dysfunction.
Paracrine HGF/c-MET enhances the stem cell-like potential and glycolysis of pancreatic cancer cells via activation of YAP/HIF-1α.
Functional interplay between liver X receptor and AMP-activated protein kinase α inhibits atherosclerosis in apolipoprotein E-deficient mice - a new anti-atherogenic strategy.
SET1A-Mediated Mono-Methylation at K342 Regulates YAP Activation by Blocking Its Nuclear Export and Promotes Tumorigenesis.
Activation of hepatic Nogo-B receptor expression-A new anti-liver steatosis mechanism of statins.
Ubiquitination Regulates the Proteasomal Degradation and Nuclear Translocation of the Fat Mass and Obesity-Associated (FTO) Protein.
Baicalein protects human vitiligo melanocytes from oxidative stress through activation of NF-E2-related factor2 (Nrf2) signaling pathway.
Hypoxia-Induced Mitogenic Factor Promotes Cardiac Hypertrophy via Calcium-Dependent and Hypoxia-Inducible Factor-1α Mechanisms.
DExD/H-Box Helicase 36 Signaling via Myeloid Differentiation Primary Response Gene 88 Contributes to NF-κB Activation to Type 2 Porcine Reproductive and Respiratory Syndrome Virus Infection.
PADI2-Mediated Citrullination Promotes Prostate Cancer Progression.
Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20.
ERK1/2-mediated Cytoplasmic Accumulation of hnRNPK Antagonizes TRAIL-induced Apoptosis through Upregulation of XIAP in H1299 Cells.
Highly expressed lncRNA CCND2-AS1 promotes glioma cell proliferation through Wnt/β-catenin signaling.
CRB3 regulates contact inhibition by activating the Hippo pathway in mammary epithelial cells.
TRAIL facilitates cytokine expression and macrophage migration during hypoxia/reoxygenation via ER stress-dependent NF-κB pathway.
TRIM52: A nuclear TRIM protein that positively regulates the nuclear factor-kappa B signaling pathway.
Cluster of Differentiation 36 Deficiency Aggravates Macrophage Infiltration and Hepatic Inflammation by Upregulating Monocyte Chemotactic Protein-1 Expression of Hepatocytes Through Histone Deacetylase 2-Dependent Pathway.
Nuclear retention of the lncRNA SNHG1 by doxorubicin attenuates hnRNPC-p53 protein interactions.
CRB3 downregulation confers breast cancer stem cell traits through TAZ/β-catenin.
Biallelic SUN5 Mutations Cause Autosomal-Recessive Acephalic Spermatozoa Syndrome.
Dicer interacts with SIRT7 and regulates H3K18 deacetylation in response to DNA damaging agents.
Set7 facilitates hepatitis C virus replication via enzymatic activity-dependent attenuation of the IFN-related pathway.
miR-206 modulates lipopolysaccharide-mediated inflammatory cytokine production in human astrocytes.
Novel function of PITH domain-containing 1 as an activator of internal ribosomal entry site to enhance RUNX1 expression and promote megakaryocyte differentiation.
Protective effect of astaxanthin on liver fibrosis through modulation of TGF-β1 expression and autophagy.
FHL2-driven molecular network mediated Septin2 knockdown inducing apoptosis in mesangial cell.
Novel function of the chromosome 7 open reading frame 41 gene to promote leukemic megakaryocyte differentiation by modulating TPA-induced signaling.
UDP-glucose dehydrogenase modulates proteoglycan synthesis in articular chondrocytes: its possible involvement and regulation in osteoarthritis.
Proteomic analysis of primary duck hepatocytes infected with duck hepatitis B virus.
Proteomic analysis of protein complexes in human SH-SY5Y neuroblastoma cells by using blue-native gel electrophoresis: an increase in lamin A/C associated with heat shock protein 90 in response to 6-hydroxydopamine-induced oxidative stress.
Chang Z, Wang Q, Zhai Y, Li K, Zheng X, Wang Y, Zhao D
PloS one 2026;21(2):e0343036
PloS one 2026;21(2):e0343036
LBR and LAP2 mediate heterochromatin tethering to the nuclear periphery to preserve genome homeostasis.
Lewis R, Sinigiani V, Maziak N, Koos K, Bersaglieri C, Zemp I, Ashiono C, Ciaudo C, Horvath P, Vaquerizas JM, Santoro R, Sharma P, Kutay U
Nature cell biology 2026 Mar;28(3):536-552
Nature cell biology 2026 Mar;28(3):536-552
The natural flavonoid dihydromyricetin targets senescent cells via PRDX2 and alleviates age-related diseases.
Xu Q, Li G, Zhang H, Jiang Z, Gao X, Li Z, Langhi Prata LGP, Kirkland JL, Zhang G, Sun Y
Nature communications 2026 Mar 6;17(1)
Nature communications 2026 Mar 6;17(1)
Downregulation of TDP43 by atovaquone inhibits oxidative phosphorylation and enhances sensitivity of triple-negative breast cancer to EGFR-TKIs.
Lin L, Ke H, Chen M, Zhang Y, Fu S, Yu F, Su J, Yang X, Guo Y, Ding Q, Zhang Y, Zhao L
Free radical biology & medicine 2026 Jul;250:64-79
Free radical biology & medicine 2026 Jul;250:64-79
Gypenoside L inhibits oral squamous cell carcinoma progression by targeting the AKT signaling pathway.
Lai DY, Chen Y, Lan T, Zheng DL, Lu YG, Gan RH
Bioorganic chemistry 2026 Jan;168:109303
Bioorganic chemistry 2026 Jan;168:109303
Shikonin improves intestinal barrier function through modulation of GPX4 expression in intestinal epithelial cells.
Yang F, Liang P, Guo H, Yan W, Wang G, Tang X, Liang Z
International journal of immunopathology and pharmacology 2026 Jan-Dec;40:3946320261427239
International journal of immunopathology and pharmacology 2026 Jan-Dec;40:3946320261427239
KIF2A-mediated microtubule-dependent nuclear envelope invagination drives nonhomologous end joining.
Ma Y, Zhang T, Zhou XA, Xu Z, Zhou J, Aili A, Li P, Nie C, Xiong Y, Li X, Cao B, Li S, Wang J
Nucleic acids research 2026 Jan 22;54(3)
Nucleic acids research 2026 Jan 22;54(3)
UBC9-mediated regulation of K144 ubiquitination of Lamin A and its implications for hepatocellular carcinoma.
Wang Q, Liao Z, Zhang H, Jin Z, Zhong Z, Gao X, Huang Y, Qiu M, Ren W, Liu Y, Zhang L, Fan R, Feng Y, Zhang K, Assaraf YG, Lin Y
Journal of translational medicine 2026 Jan 22;24(1):250
Journal of translational medicine 2026 Jan 22;24(1):250
DNA damage in macrophages drives immune autoreactivity via nuclear antigen presentation.
Niotis G, Arvanitaki ES, Theodorakis E, Schmalen A, Juretschke T, Argyros O, Tsolis KC, Bertsias G, Drakos E, Beli P, Garinis GA
Nature aging 2026 Feb;6(2):393-413
Nature aging 2026 Feb;6(2):393-413
Gastrodin alleviates alcohol-induced developmental and neurotoxic effects in zebrafish larvae by suppressing ferroptosis via regulating the Nrf2/GPX4 signaling pathway.
Li R, Yang W, Zheng L, Yan X, Liu C, Zhang Y, Li J
Toxicology and applied pharmacology 2026 Feb;507:117684
Toxicology and applied pharmacology 2026 Feb;507:117684
Ezetimibe attenuates diabetic retinopathy via NRF2-mediated suppression of inflammation and oxidative stress.
Cheng L, Cheng S, Zhu R, Xu G
Journal of diabetes and its complications 2026 Feb;40(2):109250
Journal of diabetes and its complications 2026 Feb;40(2):109250
Rabeprazole attenuates fibrosis by modulating SMAD3 linker region phosphorylation.
Li L, Liang Z, Fan L, Cao Y, Tang X, Chen J
Biomedical reports 2026 Feb;24(2):25
Biomedical reports 2026 Feb;24(2):25
Aronia Berry Extract Inhibits Cancer Stemness and Overcomes 5-Fluorouracil Resistance by Targeting TLR3/NF-κB Signaling in Colorectal Cancer.
Duan H, Noma T, Goel A
Pharmaceuticals (Basel, Switzerland) 2026 Feb 3;19(2)
Pharmaceuticals (Basel, Switzerland) 2026 Feb 3;19(2)
Enolase 1 suppresses influenza A virus replication by blocking the nuclear import of the viral ribonucleoprotein complex.
Kong X, Liu J, Zhu Q, Xu S
Cellular and molecular life sciences : CMLS 2026 Feb 25;83(1)
Cellular and molecular life sciences : CMLS 2026 Feb 25;83(1)
Research on the mechanism of CRMP4-mediated cytoskeletal actin polymerization in promoting invasive migration of stromal cells in endometriosis.
Song L, Guo J, Yin L, Guo H, Ji G, Zhang Y, Hu R
Journal of translational medicine 2026 Feb 19;24(1)
Journal of translational medicine 2026 Feb 19;24(1)
A human patient-derived organoid biobank to model tumor heterogeneity and therapeutic vulnerability for oral squamous cell carcinoma.
Wang Y, Diao P, Lv P, Qi N, Wang Z, Yan E, Li J, Wang Y, Wang D, Wu Y, Cheng J
Cell reports. Medicine 2026 Feb 17;7(2):102622
Cell reports. Medicine 2026 Feb 17;7(2):102622
Computational-experimental integration reveals PPARγ/Nrf2-GPX4 dual-targeting by combined selenomethionine-magnolol as a novel therapy for sarcopenic obesity.
Li Z, Liu B, Zhou L, Chen N, Wang Y, Yang S, Fan X, Wang Y, Chen X
Free radical biology & medicine 2026 Apr 7;251:243-255
Free radical biology & medicine 2026 Apr 7;251:243-255
FKBP10 Promotes the Muscle Invasion of Bladder Cancer via Lamin A Dysregulation.
Zhao X, Wang J, Tian S, Tang L, Cao S, Ye J, Cai T, Xuan Y, Zhang X, Li X, Li H
International journal of biological sciences 2025;21(2):758-771
International journal of biological sciences 2025;21(2):758-771
Silencing NRF2 enhances arsenic trioxide-induced ferroptosis in hepatocellular carcinoma cells.
Huang M, Li D, Xia Z, Liao S, Si W, Yuan C, Liao Y, Wu W, Jiang M, Yu X, Quan Y
PloS one 2025;20(5):e0322746
PloS one 2025;20(5):e0322746
Hepatic ASPG-mediated lysophosphatidylinositol catabolism impairs insulin signal transduction.
Li F, Huang HS, Zhao Q, Zhang W, Shi T, Lv W, Zhu Q, Liu H, Xu Y, Huang H, Tang QQ, Gao Y, Peng T, Pan D
The EMBO journal 2025 Sep;44(18):5005-5036
The EMBO journal 2025 Sep;44(18):5005-5036
Glutaredoxin 1 enhances endothelial cell angiogenesis by reducing VEGFA S-glutathionylation and delays vascular endothelial cell senescence.
Li F, Cui X, Yan Y, Jing X, Bai C, He D, Wang L, Gao C, Li M, Feng R
Free radical biology & medicine 2025 Sep;237:515-529
Free radical biology & medicine 2025 Sep;237:515-529
Nuclear force transmission drives cancer-associated fibroblast activation under BRAF inhibition.
Wang J, Soley BDS, Xiao Y, Siegfried LG, Zhou L, Xu M, Millar SE, Andl T, Zhang Y
bioRxiv : the preprint server for biology 2025 Sep 9;
bioRxiv : the preprint server for biology 2025 Sep 9;
Kuwanon A Targeted YWHAB in Hepatocellular Carcinoma Cells to Inhibit the Raf/MEK/ERK Signaling Pathway.
Xu J, Chang H, Wang Y, Du Y, Zhong L, Cui H
Cells 2025 Sep 23;14(19)
Cells 2025 Sep 23;14(19)
Oxidative stress-induced ZEB1 acetylation drives a hybrid epithelial-mesenchymal phenotype and promotes lung metastasis in triple-negative breast cancer.
Guo M, Wang YJ, Shi J, Cao LX, Ou Y, Jia X, Qi CC, Li ZX, Liu YX, Zuo SY, Shuai QY, Yu TW, Hu HY, Chen X, Feng MD, Xue Y, Wang H, Sun PQ, Liu L, Shi Y, Yang S
Redox biology 2025 Oct;86:103834
Redox biology 2025 Oct;86:103834
Novel LBR pathogenic variants with loss of sterol reductase activity participate in the pathogenesis of skeletal dysplasia via dysregulating canonical Wnt pathway.
Chen Y, Bai Y, Deng D, Liu Y, He L, Wang M, Zhou M, Wang X, Yu C, Wang Y, Zhao F, Hai C, Wang B, Liu J, Kong X, Tu X, Li H
Biochimica et biophysica acta. Molecular basis of disease 2025 Oct;1871(7):167901
Biochimica et biophysica acta. Molecular basis of disease 2025 Oct;1871(7):167901
PPP1CA promotes hepatocellular carcinoma progression in a YAP1-dependent way.
Liu X, Xu G, Luo W, Wang K, Wang F
Cellular signalling 2025 Oct;134:111938
Cellular signalling 2025 Oct;134:111938
The deubiquitination enzyme USP14 promotes the tumourigenesis of gastric cancer by enhancing c-MYC nuclear translocation through deubiquitination of KPNA2.
Li J, Tang H, Chang H, Du Y, Du L, Zhao E
Cell death & disease 2025 Oct 21;16(1):737
Cell death & disease 2025 Oct 21;16(1):737
TRAP1 inhibits KANSL3 acetylation to alleviate mitochondrial dysfunction by promoting mitophagy in cardiomyocytes under diabetic conditions.
Zhang X, Cheng S, Li W, Xu X, Huang X, Chen Z, Li Q, Huang W, Zhang L, Ouyang M
Cell communication and signaling : CCS 2025 Oct 2;23(1):414
Cell communication and signaling : CCS 2025 Oct 2;23(1):414
Centromere protein I facilitates breast cancer tumorigenesis and disease progression through modulation of Wnt/β-Catenin signaling.
Wu C, Zhou Y, Mu Y, Cheng Y, Xu W, Huang M, Xu J, Li M, Gu J, Meng X, Qian D
Cancer cell international 2025 Oct 10;25(1):348
Cancer cell international 2025 Oct 10;25(1):348
KSRP-mediated Wnt/β-catenin activation promotes follicular thyroid cancer progression and stemness.
Pan KF, Chou HL, Wang WL, Chen BR, Hsiao M, Hua KT, Wu MH
British journal of cancer 2025 Nov;133(8):1111-1121
British journal of cancer 2025 Nov;133(8):1111-1121
Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels.
Cherdyntseva V, Paulson J, González-Acosta D, Ubieto-Capella P, Rodrigues M, Aouami M, Adakli S, Gagné JP, Bakker C, Poirier GG, Taneja N, Lopes M
Nature communications 2025 Nov 29;16(1):11239
Nature communications 2025 Nov 29;16(1):11239
A nucleoskeleton network preserves genomic integrity by promoting NHEJ and restraining chromosome translocations.
Liu J, Bai X, Chen X, Li B, Zhao H, Wu J, Ye Y, Yu J, Yan Z, Guo R, Xu D, Li W
Nucleic acids research 2025 Nov 26;53(22)
Nucleic acids research 2025 Nov 26;53(22)
RBMX2 links Mycobacterium bovis infection to epithelial-mesenchymal transition and lung cancer progression.
Wang C, Peng Y, Yang H, Jiang Y, Khalid AK, Zhang K, Xie S, Bermudez L, Yang Y, Zhang L, Chen H, Guo A, Chen Y
eLife 2025 Nov 24;14
eLife 2025 Nov 24;14
The Wnt/APC destruction complex targets SREBP2 in a β-catenin-independent pathway to control cholesterol metabolism.
Rattani A, Anderson C, Trim WV, Garita E, Imada S, Khawaled S, Shin H, Zhang J, Yilmaz ÖH, Kirschner M
bioRxiv : the preprint server for biology 2025 Nov 18;
bioRxiv : the preprint server for biology 2025 Nov 18;
PNMA4 enhances anti-RNA virus immunity by promoting RIG-I signaling pathway.
Song H, Li ZW, Xie YT, Tang X, Hu YT, Tan Y, Huang Y, Cheng YL, Pei G, Kuang M
International immunopharmacology 2025 Nov 14;165:115446
International immunopharmacology 2025 Nov 14;165:115446
NFAT2 Induces Tumor Cell Proliferation and Metastasis by Acting as a Transcriptional Co-activator of the TGF-β1/SMAD Signaling Pathway and Inducing the Epithelial-Mesenchymal Transition in Liver Cancer.
Liu Y, Mo W, Sun W, Chen J, Chen J, Li Y, Han D, Dai W, Zhang R
Digestive diseases and sciences 2025 May;70(5):1799-1812
Digestive diseases and sciences 2025 May;70(5):1799-1812
Epithelial-Mesenchymal Plasticity in the D-Meso-Sonobe Mesothelioma Cell Line: A Putative Model of Epithelial-Mesenchymal Transition in Mesothelioma.
Okubo H, Hanamatsu Y, Saigo C, Hiroshi S, Takeuchi T
Thoracic cancer 2025 May;16(10):e70091
Thoracic cancer 2025 May;16(10):e70091
Bicuculline ameliorates metabolic dysfunction-associated steatotic liver disease by inhibiting the nuclear factor-kappa B pathway and reducing lipid accumulation.
Wang XM, Dai Z, Lu DJ, Bao CQ, Yang NB, Zhou YP
World journal of gastroenterology 2025 May 7;31(17):105438
World journal of gastroenterology 2025 May 7;31(17):105438
THG-1/TSC22D4 Promotes IL-1 Signaling through Stabilization of TRAF6 in Squamous Cell Carcinoma.
Okano Y, Suzuki H, Watanabe Y, Abdelaziz M, Manevich L, Kawanishi K, Ozaki H, Ishii R, Matsumoto S, Goto N, Zheng L, Okita Y, Hwang J, Nakayama M, Shima Y, Sakamoto N, Noguchi M, Tabuchi K, Kato M
Molecular cancer research : MCR 2025 May 2;23(5):463-476
Molecular cancer research : MCR 2025 May 2;23(5):463-476
Dietary coconut oil lowered circulating fetuin-A levels and hepatic expression of fetuin-A in KK/TaJcl mice.
Iizuka Y, Kitagawa C, Tamura T, Ueshiba H, Hirako S, Osaka T, Kim H, Yanagisawa N
Journal of clinical biochemistry and nutrition 2025 Mar;76(2):131-138
Journal of clinical biochemistry and nutrition 2025 Mar;76(2):131-138
Chlorophyllides repress gain-of-function p53 mutated HNSCC cell proliferation via activation of p73 and repression of p53 aggregation in vitro and in vivo.
Cai BH, Wang YT, Chen CC, Yeh FY, Lin YR, Lin YC, Wu TY, Wu KY, Lien CF, Shih YC, Shaw JF
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167662
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167662
ASPM mediates nuclear entrapment of FOXM1 via liquid-liquid phase separation to promote progression of hepatocarcinoma.
Jiang X, Liu J, Wang K, Sun J, Yin H, Jiang Y, Liu Y, Wang N, Ding X, Gao P, Li L, Zhang X, Li J, Zhang R
Genome biology 2025 Mar 23;26(1):68
Genome biology 2025 Mar 23;26(1):68
PKM2 knockout facilitates the activation of the AMPK/KLF4/ACADVL pathway, leading to increased oxidative degradation of fatty acids in TNBC.
Zhang L, Cheng L, Ma Y, Li J, Zhong Y, Zhu X, Leng X, Xie F
Medical oncology (Northwood, London, England) 2025 Mar 12;42(4):102
Medical oncology (Northwood, London, England) 2025 Mar 12;42(4):102
Activation of megakaryocytic leukemia 1 in endothelial cells contributes to diabetic retinopathy in mice.
Zhu Y, Feng X, Wang F, Ding Y
Life sciences 2025 Mar 1;364:123425
Life sciences 2025 Mar 1;364:123425
Delivery of LOXL1-AS1-siRNAs using targeting peptide-engineered extracellular vesicles with focused ultrasound to suppress medulloblastoma metastasis.
Do AD, Chu SS, Giang LH, Huang PL, Lin YL, Chang CC, Wong TT, Sung SY, Hsieh CL
Journal of nanobiotechnology 2025 Jun 24;23(1):460
Journal of nanobiotechnology 2025 Jun 24;23(1):460
Fatty Acid Desaturase 1 Knockdown Promotes Wound Healing and Functional Recovery of the Corneal Epithelium in Diabetes.
Zhao Y, Dong Y, Zheng Q, Zhao Y, Ni Y, Qiu P, Chen C, Xu M, Hong C, Shen T
Investigative ophthalmology & visual science 2025 Jun 2;66(6):6
Investigative ophthalmology & visual science 2025 Jun 2;66(6):6
E2-Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells.
Shen S, Yin H
Nature chemical biology 2025 Jul;21(7):1089-1099
Nature chemical biology 2025 Jul;21(7):1089-1099
Adducin-1 Facilitates Influenza Virus Endosomal Trafficking and Uncoating by Regulating Branched Actin Dynamics and Myosin IIB Activity.
Jiang M, Zou J, Jin Y, Jiang C, Tu S, Chen T, Guo J, Cheng Y, Jin M, Chen H, Zhou H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(28):e2417318
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(28):e2417318
Paeonol ameliorates diabetic nephropathy by promoting TFEB-mediated lysosome biogenesis and lipophagy.
Ai S, Tao J, Wang Y, Zhou J, Liu W, Li X, Wang L, Hou J, Zhao L, Wang Z, Peng L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156901
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156901
The important role of the Wnt/β-catenin signaling pathway in small molecules mediated gingival mesenchymal stem cells transdifferentiate into neuron-like cells.
Liang Q, Zhang C, Lv P, Huang Y, Zhao H, Jiang S, Xu W
Archives of oral biology 2025 Jan;169:106115
Archives of oral biology 2025 Jan;169:106115
Inhibiting intracellular CD28 in cancer cells enhances antitumor immunity and overcomes anti-PD-1 resistance via targeting PD-L1.
Yang Z, Liu X, Zhu J, Chai Y, Cong B, Li B, Gao W, Hu Y, Wen M, Liu Y, Fu L, Cao X
Cancer cell 2025 Jan 13;43(1):86-102.e10
Cancer cell 2025 Jan 13;43(1):86-102.e10
Clinical Significance of Acyl-CoA Dehydrogenase Short Chain and Its Anti-tumor Role in Hepatocellular Carcinoma by Inhibiting Canonical Wnt/β-Catenin Pathway.
Gu J, Cao Z, Niu G, Ying J, Wang H, Jiang H, Ke C
Digestive diseases and sciences 2025 Feb;70(2):622-637
Digestive diseases and sciences 2025 Feb;70(2):622-637
Engineered protein G variants for multifunctional antibody-based assemblies.
Slezak T, O'Leary KM, Li J, Rohaim A, Davydova EK, Kossiakoff AA
Protein science : a publication of the Protein Society 2025 Feb;34(2):e70019
Protein science : a publication of the Protein Society 2025 Feb;34(2):e70019
ZDHHC3-LYPLA1 regulates PRRSV-2 replication through reversible palmitoylation.
Jing H, Liu Y, Song Y, Song T, Wang T, Ding Z, Liu J, Zhao P
Veterinary microbiology 2025 Feb;301:110368
Veterinary microbiology 2025 Feb;301:110368
Mechanical Force-Induced cGAS Activation in Carcinoma Cells Facilitates Splenocytes into Liver to Drive Metastasis.
Zhang X, Huang N, Mu Y, Chen H, Zhu M, Zhang S, Liu P, Zhang H, Deng H, Feng K, Shang Q, Liu X, Zhang C, Shi M, Yang L, Sun J, Kong G, Geng J, Lu S, Li Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(8):e2401127
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(8):e2401127
Clofarabine induces tumor cell apoptosis, GSDME-related pyroptosis, and CD8(+) T-cell antitumor activity via the non-canonical P53/STING pathway.
Wu J, Liu N, Chen J, Tao Q, Lu C, Li Q, Chen X, Peng C
Journal for immunotherapy of cancer 2025 Feb 6;13(2)
Journal for immunotherapy of cancer 2025 Feb 6;13(2)
FAM210B activates STAT1/IRF9/IFIT3 axis by upregulating IFN-α/β expression to impede the progression of lung adenocarcinoma.
Gao X, Huang D, Liu Y, Zhang G, Zheng X, Guan B, Chen A, Wu J, Luo SM, Liu Z, Chen L, Liu X, Jin J, Yin X, Sun Z, Zhang Y, Lu M, Zhang G, Liu W, Liu L
Cell death & disease 2025 Feb 3;16(1):63
Cell death & disease 2025 Feb 3;16(1):63
Nucleolar NOL9 regulated by DNA methylation promotes hepatocellular carcinoma growth through activation of Wnt/β-catenin signaling pathway.
Chen X, Song X, Zheng X, Qian T, Zhang B, Wu L, Lian Q, Chen J, Luo Q, Xu W, Peng L, Xie C
Cell death & disease 2025 Feb 15;16(1):100
Cell death & disease 2025 Feb 15;16(1):100
ATR-hippo drives force signaling to nuclear F-actin and links mechanotransduction to neurological disorders.
Chatzifrangkeskou M, Stanly T, Koennig D, Campos-Soares L, Eyres M, Hasson A, Perdiou A, Vendrell I, Fischer R, Das S, Gardner S, Go S, Futcher B, Newton A, Skourides P, Szele F, O'Neill E
Science advances 2025 Feb 14;11(7):eadr5683
Science advances 2025 Feb 14;11(7):eadr5683
Propofol inhibits glioma growth by blocking the formation of the NF-κB/LGI4 feedback loop to activate TP53 self-transcription.
Wang Z, Zhang LN, Wu T, Pan X, Li L
Translational oncology 2025 Dec;62:102578
Translational oncology 2025 Dec;62:102578
Mechanotransduction Mediated by PDLIM5: The Critical Role of Serpin E2/Integrin β3-Cytoskeleton-Nucleoskeleton Axis in Mechanical Osteogenic Programming.
Yang Y, Wu S, Wang Y, Tang J, Liu J, Wang J, Li Y, Khan AU, Khan MA, Liu W, Zhu J, Hu K, Dai J, Ouyang J
Cell proliferation 2025 Dec;58(12):e70067
Cell proliferation 2025 Dec;58(12):e70067
Integrative single-cell and spatial transcriptome analysis reveals the functions of TREM2(high) macrophages and infarct border dynamics post-myocardial infarction.
Xiong T, Chen Y, Liu C, Li Y, Zhang Y, Chang Q
Molecular and cellular biochemistry 2025 Dec;480(12):6077-6109
Molecular and cellular biochemistry 2025 Dec;480(12):6077-6109
Dual-wavelength UV photofunctionalization of 3D-printed Ti6Al4V porous bone implant enhances osseointegration via adhesion-cytoskeleton-nuclear mechanotransduction.
Yin C, Fang Y, Sun X, Jing Z, Fu J, Sun L, Hou Y, Lee EB, Zhang T, Wang Y, Hao Y
Materials today. Bio 2025 Dec;35:102581
Materials today. Bio 2025 Dec;35:102581
miR-140-5p Overexpression Contributes to Oxidative Stress and Mitochondrial Dysfunction in Hutchinson-Gilford Progeria Syndrome Fibroblasts Through NRF2 Pathway.
Toury L, Frankel D, Nael S, Abaji M, Le Goff L, Basset M, Airault C, Vernay B, Novoa-Del-Toro EM, Bartoli C, Baudot A, Magdinier F, Kaspi E, Roll P
Aging cell 2025 Dec;24(12):e70276
Aging cell 2025 Dec;24(12):e70276
ALFA nanobody-guided endogenous labeling.
Wang Z, Hu F, Xue F, He W, Yuan L, Xu P
Nature chemical biology 2025 Dec;21(12):1992-2001
Nature chemical biology 2025 Dec;21(12):1992-2001
SerpinA3N-APOE interaction in astrocytes exacerbates Alzheimer's disease progression through NFκB activation.
Liu C, Xu S, Yao H, Wang Y, Liu Q, Zhou H, Luo Y, Li X, Li S, Li C
Journal of neuroinflammation 2025 Dec 4;23(1):8
Journal of neuroinflammation 2025 Dec 4;23(1):8
SREBP1-mediated lipogenesis promotes dedifferentiation and senescence of vascular smooth muscle cells through epigenetic remodeling.
Li B, Zhou K, Yin A, Liu Y, Wang X, Cui Y, Liu F, Liu Q, Zheng H, Mu Z, Chen K, Wu Y, Chang Y, Bao J
Nature communications 2025 Dec 26;17(1):835
Nature communications 2025 Dec 26;17(1):835
Resveratrol Prevents Breast Cancer Metastasis by Inhibiting Wnt/β-Catenin Pathway-Mediated Epithelial-Mesenchymal Transition.
Fang X, Ma E, Wang R, Zhang J, Tang Y, Chen J, Zhu W, Wo D, Ren DN
Pharmaceuticals (Basel, Switzerland) 2025 Dec 23;19(1)
Pharmaceuticals (Basel, Switzerland) 2025 Dec 23;19(1)
Cytomegalovirus disrupts Lamin A/C to control microtubule-mediated nuclear movement and cell migration.
Mahmud J, Nandi I, J Procter D, Walsh D
Proceedings of the National Academy of Sciences of the United States of America 2025 Dec 2;122(48):e2507831122
Proceedings of the National Academy of Sciences of the United States of America 2025 Dec 2;122(48):e2507831122
P2X7-CaMKII drives 5-LOX nuclear translocation to impair microglial function after subarachnoid hemorrhage.
Ding PF, Zhang JT, Zhu XL, Cui Y, Chen CL, Liu XZ, Shen JD, Zou LX, Lu Y, Zhuang Z, Hang CH, Li W
Journal of neuroinflammation 2025 Aug 28;22(1):208
Journal of neuroinflammation 2025 Aug 28;22(1):208
PAD2 disturbs cardiomyocyte calcium homeostasis by citrullinating SERCA2a protein in hemorrhagic shock induced arrhythmia.
Gan L, Li R, Wang Q, Zhou J, Zhang M, Leng M, Zhao J, Yang F, Jia S, Huang W, Ye J, Zheng M, Wang T
The journal of trauma and acute care surgery 2025 Aug 1;99(2):219-232
The journal of trauma and acute care surgery 2025 Aug 1;99(2):219-232
Subcellular proteomics reveals the crosstalk between nucleocytoplasmic trafficking and the innate immune response to Senecavirus A infection.
Li M, Deng X, Zhou M, Wan H, Shi Y, Zhang L, He W, Zhang Y, Hu M, Du Y, Jiang D, Han S, Wan B, Zhang G
International journal of biological macromolecules 2025 Apr;298:139898
International journal of biological macromolecules 2025 Apr;298:139898
CRM1 mediates ASC nuclear export and inflammasome activation.
Cao R, Lin B, He H, Wang D, Wang X, Huang Y, Zhou R
International immunopharmacology 2025 Apr 24;153:114503
International immunopharmacology 2025 Apr 24;153:114503
PRMT5-mediated methylation of METTL3 promotes cisplatin resistance in ovarian cancer by facilitating DNA repair mechanisms.
Xia Q, Zhong R, Zheng J, Zhou X, Zhao X, Wang S, Wang B, Wu Q, Xie C, Kong B, Zhang Q, Huang T
Cell reports 2025 Apr 22;44(4):115484
Cell reports 2025 Apr 22;44(4):115484
Macropinocytosis regulates cytokine expression through Erk signaling in LPS-stimulated macrophages.
Wang L, Li Y, He Y, Fang Y, Mimuro H, Midgley AC, Yoshida S
Cell structure and function 2025 Apr 18;50(1):103-113
Cell structure and function 2025 Apr 18;50(1):103-113
Hepatitis B surface antigen hijacks TANK-binding kinase 1 to suppress type I interferon and induce early autophagy.
Luo C, Ma C, Xu G, Lu C, Ma J, Huang Y, Nie L, Yu C, Xia Y, Liu Z, Zhu Y, Liu S
Cell death & disease 2025 Apr 15;16(1):304
Cell death & disease 2025 Apr 15;16(1):304
The LysoPS/GPR174 axis drives metastatic progression in esophageal squamous cell carcinoma through cAMP-PKA-CREB signaling activation.
Xiao R, Xu P, Li X, Shen F, Tao S, Zhu X, Cai Y, Feng Z, Liu Z, Xiao H, Ding F, Zhu M
Journal of translational medicine 2025 Apr 14;23(1):438
Journal of translational medicine 2025 Apr 14;23(1):438
Sorbitol Destroyed Intestinal Microfold Cells (M Cells) Development through Inhibition of PDE4-Mediated RANKL Expression.
Xiang L, Pan W, Chen H, Du W, Xie S, Liang X, Yang F, Niu R, Huang C, Luo M, Xu Y, Geng L, Gong S, Xu W, Zhao J
Mediators of inflammation 2024;2024:7524314
Mediators of inflammation 2024;2024:7524314
Conditioned Medium Derived From Human Dental Follicle Mesenchymal Stem Cells Alleviates Macrophage Proinflammatory Responses Through MAPK-ERK-EGR1 Axis.
Zhang C, Lv P, Liang Q, Zhou J, Wu B, Xu W
Stem cells international 2024;2024:5514771
Stem cells international 2024;2024:5514771
TGFβ1-Induced Fibrotic Responses of Conjunctival Fibroblasts through the Wnt/β-Catenin/CRYAB Signaling Pathway.
Wang X, Chen K, Yao Y, Lin Y, Yang J, Zhu Y, Zhou B
The American journal of pathology 2024 Sep;194(9):1764-1779
The American journal of pathology 2024 Sep;194(9):1764-1779
GRP75 triggers white adipose tissue browning to promote cancer-associated cachexia.
Chen X, Wu Q, Gong W, Ju S, Fan J, Gao X, Liu X, Lei X, Liu S, Ming X, Wang Q, Fu M, Song Y, Wang Y, Zhan Q
Signal transduction and targeted therapy 2024 Sep 26;9(1):253
Signal transduction and targeted therapy 2024 Sep 26;9(1):253
Nogo-B inhibition facilitates cholesterol metabolism to reduce hypercholesterolemia.
Xue C, Zeng P, Gong K, Li Q, Feng Z, Wang M, Chen S, Yang Y, Li J, Zhang S, Yin Z, Liang Y, Yan T, Yu M, Feng K, Zhao D, Yang X, Zhang X, Ma L, Iwakiri Y, Chen L, Tang X, Chen Y, Chen H, Duan Y
Cell reports 2024 Sep 24;43(9):114691
Cell reports 2024 Sep 24;43(9):114691
Zinc-finger CCHC-type containing protein 8 promotes RNA virus replication by suppressing the type-I interferon responses.
Tu S, Zou J, Xiong C, Dai C, Sun H, Luo D, Jin M, Chen H, Zhou H
Journal of virology 2024 Sep 17;98(9):e0079624
Journal of virology 2024 Sep 17;98(9):e0079624
Sirt2 Regulates Liver Metabolism in a Sex-Specific Manner.
Schmidt AV, Bharathi SS, Solo KJ, Bons J, Rose JP, Schilling B, Goetzman ES
Biomolecules 2024 Sep 15;14(9)
Biomolecules 2024 Sep 15;14(9)
Identification of a novel caspase cleavage motif AEAD.
Fang Y, Gong Z, You M, Peng K
Virologica Sinica 2024 Oct;39(5):755-766
Virologica Sinica 2024 Oct;39(5):755-766
The syntaxin-binding protein STXBP5 regulates progerin expression.
Qi H, Wu Y, Zhang W, Yu N, Lu X, Liu J
Scientific reports 2024 Oct 8;14(1):23376
Scientific reports 2024 Oct 8;14(1):23376
Epigenetic Regulation of CXC Chemokine Expression by Environmental Electrophiles Through DNA Methyltransferase Inhibition.
Tsuchida T, Kubota S, Kamiuezono S, Takasugi N, Ito A, Kumagai Y, Uehara T
International journal of molecular sciences 2024 Oct 29;25(21)
International journal of molecular sciences 2024 Oct 29;25(21)
Macropinocytic cups function as signal platforms for the mTORC2-AKT pathway to modulate LPS-induced cytokine expression in macrophages.
Wang L, Sun X, Chen J, Li Y, He Y, Wei J, Shen Z, Yoshida S
Journal of leukocyte biology 2024 Oct 1;116(4):738-752
Journal of leukocyte biology 2024 Oct 1;116(4):738-752
SUN2 mediates calcium-triggered nuclear actin polymerization to cluster active RNA polymerase II.
Ulferts S, Grosse R
EMBO reports 2024 Nov;25(11):4728-4748
EMBO reports 2024 Nov;25(11):4728-4748
USP2 Mitigates Reactive Oxygen Species-Induced Mitochondrial Damage via UCP2 Expression in Myoblasts.
Kitamura H, Fujimoto M, Hashimoto M, Yasui H, Inanami O
International journal of molecular sciences 2024 Nov 6;25(22)
International journal of molecular sciences 2024 Nov 6;25(22)
EHD1 promotes breast cancer metastasis through upregulating HIF2a expression via activating mTOR pathway.
Gao X, Li J, Feng X, Xie Y, Zhang J, Liu J, Wang B, Liu P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Nov 15;38(21):e70168
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Nov 15;38(21):e70168
Excessive linoleic acid induces muscle oxidative stress through 5-lipoxygenase-dependent peroxidation.
Cao X, Guo H, Dai Y, Jiang G, Liu W, Li X, Zhang D, Huang Y, Wang X, Hua H, Wang J, Chen K, Chi C, Liu H
Redox biology 2024 May;71:103096
Redox biology 2024 May;71:103096
UBC9-mediated SUMOylation of Lamin B1 enhances DNA-damage-induced nuclear DNA leakage and autophagy after spinal cord injury.
Fan YP, Lou JS, Jin MR, Zhou CH, Shen HH, Fu CY, Mao XJ, Chen YY, Zhong JJ, Wang LL, Wu JS
Journal of cellular physiology 2024 May;239(5):e31213
Journal of cellular physiology 2024 May;239(5):e31213
Genetic and pharmacological modulation of lamin A farnesylation determines its function and turnover.
Foo MXR, Ong PF, Yap ZX, Maric M, Bong CJS, Dröge P, Burke B, Dreesen O
Aging cell 2024 May;23(5):e14105
Aging cell 2024 May;23(5):e14105
N6-Methyladenosine Modification of lncCCKAR-5 Regulates Autophagy in Human Umbilical Cord Mesenchymal Stem Cells by Destabilizing LMNA and Inhibits Diabetic Wound Healing.
Wang J, Wang X, Chen F, Ning Q, Liu Y, Zhu Y, Wei W, Leng M, Wang Z, Jin P, Li Q
The Journal of investigative dermatology 2024 May;144(5):1148-1160.e15
The Journal of investigative dermatology 2024 May;144(5):1148-1160.e15
SETDB1 modulates the TGFβ response in Duchenne muscular dystrophy myotubes.
Granados A, Zamperoni M, Rapone R, Moulin M, Boyarchuk E, Bouyioukos C, Del Maestro L, Joliot V, Negroni E, Mohamed M, Piquet S, Bigot A, Le Grand F, Albini S, Ait-Si-Ali S
Science advances 2024 May 3;10(18):eadj8042
Science advances 2024 May 3;10(18):eadj8042
P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting p-tau217 with immunotherapy ameliorates murine tauopathy.
Zhang D, Zhang W, Ming C, Gao X, Yuan H, Lin X, Mao X, Wang C, Guo X, Du Y, Shao L, Yang R, Lin Z, Wu X, Huang TY, Wang Z, Zhang YW, Xu H, Zhao Y
Neuron 2024 May 15;112(10):1676-1693.e12
Neuron 2024 May 15;112(10):1676-1693.e12
Chicken UFL1 Restricts Avian Influenza Virus Replication by Disrupting the Viral Polymerase Complex and Facilitating Type I IFN Production.
Li W, Lin Y, Wang X, Yang H, Ding Y, Chen Z, He Z, Zhang J, Zhao L, Jiao P
Journal of immunology (Baltimore, Md. : 1950) 2024 May 1;212(9):1479-1492
Journal of immunology (Baltimore, Md. : 1950) 2024 May 1;212(9):1479-1492
Nuclear SphK2/S1P signaling is a key regulator of ApoE production and Aβ uptake in astrocytes.
Komai M, Noda Y, Ikeda A, Kaneshiro N, Kamikubo Y, Sakurai T, Uehara T, Takasugi N
Journal of lipid research 2024 Mar;65(3):100510
Journal of lipid research 2024 Mar;65(3):100510
MaiJiTong granule attenuates atherosclerosis by reducing ferroptosis via activating STAT6-mediated inhibition of DMT1 and SOCS1/p53 pathways in LDLR(-/-) mice.
Shi J, Yang MM, Yang S, Fan F, Zheng G, Miao Y, Hua Y, Zhang J, Cheng Y, Liu S, Guo Y, Guo L, Yang X, Fan G, Ma C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155489
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155489
Protocol for isolating small cytosolic dsDNA from cultured murine cells.
Dai Z, Ji H, Zheng A, Huang AL, Tang KF
STAR protocols 2024 Jun 21;5(2):102998
STAR protocols 2024 Jun 21;5(2):102998
Cell surface CD55 traffics to the nucleus leading to cisplatin resistance and stemness by inducing PRC2 and H3K27 trimethylation on chromatin in ovarian cancer.
Bharti R, Dey G, Khan D, Myers A, Huffman OG, Saygin C, Braley C, Richards E, Sangwan N, Willard B, Lathia JD, Fox PL, Lin F, Jha BK, Brown JM, Yu JS, Dwidar M, Joehlin-Price A, Vargas R, Michener CM, Longworth MS, Reizes O
Molecular cancer 2024 Jun 10;23(1):121
Molecular cancer 2024 Jun 10;23(1):121
Overexpression of FHL1 suppresses papillary thyroid cancer proliferation and progression via inhibiting Wnt/β-catenin pathway.
Chen J, Zeng C, Jin J, Zhang P, Zhang Y, Zhang H, Li Y, Guan H
Endocrine 2024 Jul;85(1):238-249
Endocrine 2024 Jul;85(1):238-249
Aronia Berry Extract Modulates MYD88/NF-kB/P-Glycoprotein Axis to Overcome Gemcitabine Resistance in Pancreatic Cancer.
Li Y, Xu C, Han H, Pascual-Sabater S, Fillat C, Goel A
Pharmaceuticals (Basel, Switzerland) 2024 Jul 9;17(7)
Pharmaceuticals (Basel, Switzerland) 2024 Jul 9;17(7)
Nuclear translocation of ISG15 regulated by PPP2R2B inhibits cisplatin resistance of bladder cancer.
Huang G, Liu J, Yu A, Luo C, Zhu J, Wang Y, Dai Z, Zhang L, Feng Z, Lu J, Dong Z, Luo J, Chen W, Chen Z
Cellular and molecular life sciences : CMLS 2024 Jul 8;81(1):292
Cellular and molecular life sciences : CMLS 2024 Jul 8;81(1):292
Eukaryotic AlaX provides multiple checkpoints for quality and quantity of aminoacyl-tRNAs in translation.
Li ZH, Zhou XL
Nucleic acids research 2024 Jul 22;52(13):7825-7842
Nucleic acids research 2024 Jul 22;52(13):7825-7842
The effect of overexpression of CyPA on gene expression in human umbilical vein endothelial cells.
Yang W, Zhou X, Li Q, Yin M, Wang N
Medicine 2024 Jul 19;103(29):e38886
Medicine 2024 Jul 19;103(29):e38886
The dual role of FSP1 in programmed cell death: resisting ferroptosis in the cell membrane and promoting necroptosis in the nucleus of THP-1 cells.
Tan X, He Y, Yu P, Deng Y, Xie Z, Guo J, Hou Q, Li P, Lin X, Ouyang S, Ma W, Xie Y, Guo Z, Chen D, Zhang Z, Zhu Y, Huang F, Zhao Z, Zhang C, Guo Z, Chen X, Peng T, Li L, Xie W
Molecular medicine (Cambridge, Mass.) 2024 Jul 15;30(1):102
Molecular medicine (Cambridge, Mass.) 2024 Jul 15;30(1):102
Sanguinarine Induces Necroptosis of HCC by Targeting PKM2 Mediated Energy Metabolism.
Kong R, Wang N, Zhou C, Zhou Y, Guo X, Wang D, Shi Y, Wan R, Zheng Y, Lu J
Cancers 2024 Jul 13;16(14)
Cancers 2024 Jul 13;16(14)
GRK5 promoted renal fibrosis via HDAC5/Smad3 signaling pathway.
Xiang H, Huang J, Song A, Liu F, Xiong J, Zhang C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23422
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23422
Targeting NANOG and FAK via Cx26-derived Cell-penetrating Peptides in Triple-negative Breast Cancer.
Mulkearns-Hubert EE, Esakov Rhoades E, Ben-Salem S, Bharti R, Hajdari N, Johnson S, Myers A, Smith IN, Bandyopadhyay S, Eng C, Downs E, Lathia JD, Reizes O
Molecular cancer therapeutics 2024 Jan 3;23(1):56-67
Molecular cancer therapeutics 2024 Jan 3;23(1):56-67
TMEM216 promotes primary ciliogenesis and Hedgehog signaling through the SUFU-GLI2/GLI3 axis.
Wang Y, Yao H, Zhang Y, Mu N, Lu T, Du Z, Wu Y, Li X, Su M, Shao M, Sun X, Su L, Liu X
Science signaling 2024 Jan 23;17(820):eabo0465
Science signaling 2024 Jan 23;17(820):eabo0465
TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis.
Hao XL, Lv YF, Li DF, Bai FH, Gong J, Pan GQ, Su LX, Wang YL, Fu WL, Liu B, Huang L, Yan D, Tan QL, Liu JY, Guo QN
Journal of translational medicine 2024 Jan 2;22(1):6
Journal of translational medicine 2024 Jan 2;22(1):6
Prothymosin α accelerates dengue virus-induced thrombocytopenia.
Yang ML, Lin CL, Chen YC, Lu IA, Su BH, Chen YH, Liu KT, Wu CL, Shiau AL
iScience 2024 Jan 19;27(1):108422
iScience 2024 Jan 19;27(1):108422
c-Fos regulated by TMPO/ERK axis promotes 5-FU resistance via inducing NANOG transcription in colon cancer.
Gui Y, Qian X, Ding Y, Chen Q, Fangyu Ye, Ye Y, Hou Y, Yu J, Zhao L
Cell death & disease 2024 Jan 17;15(1):61
Cell death & disease 2024 Jan 17;15(1):61
The novel mechanism of human norovirus induced diarrhea: Activation of PKD2 caused by HuNoVs destroyed AQP3 expression through AP2γ in intestinal epithelial cells.
Huang L, Xie S, Zhang Y, Du W, Liang X, Pan W, Yang F, Niu R, Chen H, Geng L, Xiang L, Gong S, Xu W
Life sciences 2024 Jan 15;337:122348
Life sciences 2024 Jan 15;337:122348
p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson-Gilford progeria syndrome.
Son SM, Park SJ, Breusegem SY, Larrieu D, Rubinsztein DC
Nature cell biology 2024 Feb;26(2):235-249
Nature cell biology 2024 Feb;26(2):235-249
Sodium butyrate alleviates lead-induced neuroinflammation and improves cognitive and memory impairment through the ACSS2/H3K9ac/BDNF pathway.
Li Y, Liu A, Chen K, Li L, Zhang X, Zou F, Zhang X, Meng X
Environment international 2024 Feb;184:108479
Environment international 2024 Feb;184:108479
IL-8 activates fibroblasts to promote the invasion of HNSCC cells via STAT3-MMP1.
Chen Y, Huang L, Gan RH, Yuan S, Lan T, Zheng D, Lu YG
Cell death discovery 2024 Feb 6;10(1):65
Cell death discovery 2024 Feb 6;10(1):65
Cepharanthine suppresses APC-mutant colorectal cancers by down-regulating the expression of β-catenin.
Su G, Wang D, Yang Q, Kong L, Ju X, Yang Q, Zhu Y, Zhang S, Li Y
Natural products and bioprospecting 2024 Feb 29;14(1):18
Natural products and bioprospecting 2024 Feb 29;14(1):18
Viral N protein hijacks deaminase-containing RNA granules to enhance SARS-CoV-2 mutagenesis.
Li Z, Luo L, Ju X, Huang S, Lei L, Yu Y, Liu J, Zhang P, Chi T, Ma P, Huang C, Huang X, Ding Q, Zhang Y
The EMBO journal 2024 Dec;43(24):6444-6468
The EMBO journal 2024 Dec;43(24):6444-6468
The plant extract PNS mitigates atherosclerosis via promoting Nrf2-mediated inhibition of ferroptosis through reducing USP2-mediated Keap1 deubiquitination.
Zhao Y, Zheng G, Yang S, Liu S, Wu Y, Miao Y, Liang Z, Hua Y, Zhang J, Shi J, Li D, Cheng Y, Zhang Y, Chen Y, Fan G, Ma C
British journal of pharmacology 2024 Dec;181(23):4822-4844
British journal of pharmacology 2024 Dec;181(23):4822-4844
PRMT1-mediated arginine methylation promotes YAP activation and hepatocellular carcinoma proliferation.
Yu J, Yu B, Peng Z, Zhang J, Sun J, Yang B, Xu L, Luo D
FEBS open bio 2024 Dec;14(12):2104-2112
FEBS open bio 2024 Dec;14(12):2104-2112
Spatial organizations of heterochromatin underpin nuclear structural integrity of ventricular cardiomyocytes against mechanical stress.
Fujiwara K, Inoue T, Kimoto A, Zixian J, Tokuhiro K, Yasukochi Y, Akama TO, Cai CL, Shiojima I, Kimura H, Yoshimura SH, Nakamura T, Hirai M
Cell reports 2024 Dec 24;43(12):115048
Cell reports 2024 Dec 24;43(12):115048
Exosome-delivered NR2F1-AS1 and NR2F1 drive phenotypic transition from dormancy to proliferation in treatment-resistant prostate cancer via stabilizing hormonal receptors.
Chen W, Mao Y, Zhan Y, Li W, Wu J, Mao X, Xu B, Shu F
Journal of nanobiotechnology 2024 Dec 18;22(1):761
Journal of nanobiotechnology 2024 Dec 18;22(1):761
In vitro and in vivo inhibition of the host TRPC4 channel attenuates Zika virus infection.
Chen X, Yan Y, Liu Z, Yang S, Li W, Wang Z, Wang M, Guo J, Li Z, Zhu W, Yang J, Yin J, Dai Q, Li Y, Wang C, Zhao L, Yang X, Guo X, Leng L, Xu J, Obukhov AG, Cao R, Zhong W
EMBO molecular medicine 2024 Aug;16(8):1817-1839
EMBO molecular medicine 2024 Aug;16(8):1817-1839
The Compromised Fanconi Anemia Pathway in Prelamin A-Expressing Cells Contributes to Replication Stress-Induced Genomic Instability.
Nie P, Zhang C, Wu F, Chen S, Wang L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(30):e2307751
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(30):e2307751
(CG)-SLENP: A Chemical Genetics Strategy To Selectively Label Existing Proteins and Newly Synthesized Proteins.
Wang J, Chao B, Piesner J, Kelly F, Petrie SK, Xiao X, Li BX
JACS Au 2024 Aug 26;4(8):3146-3156
JACS Au 2024 Aug 26;4(8):3146-3156
Ferritin heavy chain supports stability and function of the regulatory T cell lineage.
Wu Q, Carlos AR, Braza F, Bergman ML, Kitoko JZ, Bastos-Amador P, Cuadrado E, Martins R, Oliveira BS, Martins VC, Scicluna BP, Landry JJ, Jung FE, Ademolue TW, Peitzsch M, Almeida-Santos J, Thompson J, Cardoso S, Ventura P, Slot M, Rontogianni S, Ribeiro V, Domingues VDS, Cabral IA, Weis S, Groth M, Ameneiro C, Fidalgo M, Wang F, Demengeot J, Amsen D, Soares MP
The EMBO journal 2024 Apr;43(8):1445-1483
The EMBO journal 2024 Apr;43(8):1445-1483
Defective prelamin A processing promotes unconventional necroptosis driven by nuclear RIPK1.
Yang Y, Zhang J, Lv M, Cui N, Shan B, Sun Q, Yan L, Zhang M, Zou C, Yuan J, Xu D
Nature cell biology 2024 Apr;26(4):567-580
Nature cell biology 2024 Apr;26(4):567-580
Liver ChREBP deficiency inhibits fructose-induced insulin resistance in pregnant mice and female offspring.
Li J, Zhang S, Sun Y, Li J, Feng Z, Li H, Zhang M, Yan T, Han J, Duan Y
EMBO reports 2024 Apr;25(4):2097-2117
EMBO reports 2024 Apr;25(4):2097-2117
Nuclear deformation and cell division of single cell on elongated micropatterned substrates fabricated by DMD lithography.
Zhang D, Wu W, Zhang W, Feng Q, Zhang Q, Liang H
Biofabrication 2024 Apr 3;16(3)
Biofabrication 2024 Apr 3;16(3)
Neutrophils secrete exosome-associated DNA to resolve sterile acute inflammation.
Arya SB, Collie SP, Xu Y, Fernandez M, Sexton JZ, Mosalaganti S, Coulombe PA, Parent CA
bioRxiv : the preprint server for biology 2024 Apr 26;
bioRxiv : the preprint server for biology 2024 Apr 26;
DCDC2 inhibits hepatic stellate cell activation and ameliorates CCl(4)-induced liver fibrosis by suppressing Wnt/β-catenin signaling.
Liu QQ, Chen J, Ma T, Huang W, Lu CH
Scientific reports 2024 Apr 24;14(1):9425
Scientific reports 2024 Apr 24;14(1):9425
MAVS promotes interferon signaling in RNA virus infection by ZUFSP-mediated chromatin regulation.
Li T, Li S
International immunopharmacology 2024 Apr 20;131:111819
International immunopharmacology 2024 Apr 20;131:111819
GRAS1 non-coding RNA protects against DNA damage and cell death by binding and stabilizing NKAP.
Su T, Trang N, Zhu J, Kong L, Cheung D, Chou V, Ellis L, Huang C, Camden N, McHugh CA
bioRxiv : the preprint server for biology 2024 Apr 11;
bioRxiv : the preprint server for biology 2024 Apr 11;
Whole exome sequencing reveals novel variants associated with diminished ovarian reserve in young women.
Li N, Xu W, Liu H, Zhou R, Zou S, Wang S, Li S, Yang Z, Piao Y, Zhang Y
Frontiers in genetics 2023;14:1154067
Frontiers in genetics 2023;14:1154067
Lycium barbarum polysaccharide alleviates dextran sodium sulfate-induced inflammatory bowel disease by regulating M1/M2 macrophage polarization via the STAT1 and STAT6 pathways.
Wang J, Gao H, Xie Y, Wang P, Li Y, Zhao J, Wang C, Ma X, Wang Y, Mao Q, Xia H
Frontiers in pharmacology 2023;14:1044576
Frontiers in pharmacology 2023;14:1044576
High expression of peroxisomal D-bifunctional protein in cytosol regulates apoptosis and energy metabolism of hepatocellular carcinoma cells via PI3K/AKT pathway.
Zhang N, Wang YQ, Sun C, Shi Y, Hou LG, Yao M, Hu M, Wang XM, Ma PP, Li WJ, Jiang LL
American journal of cancer research 2023;13(5):1884-1903
American journal of cancer research 2023;13(5):1884-1903
Integrative proteomics highlight presynaptic alterations and c-Jun misactivation as convergent pathomechanisms in ALS.
Aly A, Laszlo ZI, Rajkumar S, Demir T, Hindley N, Lamont DJ, Lehmann J, Seidel M, Sommer D, Franz-Wachtel M, Barletta F, Heumos S, Czemmel S, Kabashi E, Ludolph A, Boeckers TM, Henstridge CM, Catanese A
Acta neuropathologica 2023 Sep;146(3):451-475
Acta neuropathologica 2023 Sep;146(3):451-475
Oridonin inhibits the occurrence and development of colorectal cancer by reversing the Warburg effect via reducing PKM2 dimer formation and preventing its entry into the nucleus.
Chen F, Liao J, Wu P, Cheng L, Ma Y, Zhang L, Leng X, Zhu X, Liu Z, Xie F
European journal of pharmacology 2023 Sep 5;954:175856
European journal of pharmacology 2023 Sep 5;954:175856
Optineurin tunes outside-in signaling to regulate lysosome biogenesis and phagocytic clearance in the retina.
Tan LX, Germer CJ, Thamban T, La Cunza N, Lakkaraju A
Current biology : CB 2023 Sep 25;33(18):3805-3820.e7
Current biology : CB 2023 Sep 25;33(18):3805-3820.e7
Mongolian medicine Wenguanmu ointment treats eczema by inhibiting the CKLF-1/NF-κB pathway.
Zhu L, Li XJ, Gu C, Gao Y, Zhang CS, Wang LY, Chen NH, Li G
Journal of ethnopharmacology 2023 Sep 15;313:116549
Journal of ethnopharmacology 2023 Sep 15;313:116549
FN1 mediated activation of aspartate metabolism promotes the progression of triple-negative and luminal a breast cancer.
Chen C, Ye L, Yi J, Liu T, Li Z
Breast cancer research and treatment 2023 Oct;201(3):515-533
Breast cancer research and treatment 2023 Oct;201(3):515-533
KIAA1429/VIRMA promotes breast cancer progression by m(6) A-dependent cytosolic HAS2 stabilization.
Li N, Zhu Z, Deng Y, Tang R, Hui H, Kang Y, Rana TM
EMBO reports 2023 Oct 9;24(10):e55506
EMBO reports 2023 Oct 9;24(10):e55506
Prohibitin1 facilitates viral replication by impairing the RIG-I-like receptor signaling pathway.
Zou J, Tian S, Zhu Y, Cheng Y, Jiang M, Tu S, Jin M, Chen H, Zhou H
Journal of virology 2023 Oct 31;97(10):e0092623
Journal of virology 2023 Oct 31;97(10):e0092623
Heat shock protein DNAJA2 regulates transcription-coupled repair by triggering CSB degradation via chaperone-mediated autophagy.
Huang Y, Gu L, Li GM
Cell discovery 2023 Oct 31;9(1):107
Cell discovery 2023 Oct 31;9(1):107
Enamel defects of Axenfeld-Rieger syndrome and the role of PITX2 in its pathogenesis.
Yang Y, Zhu J, Chiba Y, Fukumoto S, Qin M, Wang X
Oral diseases 2023 Nov;29(8):3654-3664
Oral diseases 2023 Nov;29(8):3654-3664
The poxvirus F17 protein counteracts mitochondrially orchestrated antiviral responses.
Meade N, Toreev HK, Chakrabarty RP, Hesser CR, Park C, Chandel NS, Walsh D
Nature communications 2023 Nov 30;14(1):7889
Nature communications 2023 Nov 30;14(1):7889
Morusinol Extracted from Morus alba Inhibits Cell Proliferation and Induces Autophagy via FOXO3a Nuclear Accumulation-Mediated Cholesterol Biosynthesis Obstruction in Colorectal Cancer.
Zhang X, Dong Z, Yang Y, Liu C, Li J, Sun W, Zhu Y, Shen Y, Wang Z, Lü M, Cui H
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16016-16031
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16016-16031
NamiRNA-enhancer network of miR-492 activates the NR2C1-TGF-β/Smad3 pathway to promote epithelial-mesenchymal transition of pancreatic cancer.
Liu S, He X, Di Y, Li Q, Li F, Ma Y, Chen L, Gao Y, Xu J, Yang S, Xu L, Corpe C, Ling Y, Zhang X, Xu J, Yu W, Wang J
Carcinogenesis 2023 May 26;44(2):153-165
Carcinogenesis 2023 May 26;44(2):153-165
Nogo-B deficiency suppresses white adipogenesis by regulating β-catenin signaling.
Li J, Sun Y, Xue C, Yang X, Duan Y, Zhao D, Han J
Life sciences 2023 May 15;321:121571
Life sciences 2023 May 15;321:121571
The well-developed actin cytoskeleton and Cthrc1 expression by actin-binding protein drebrin in myofibroblasts promote cardiac and hepatic fibrosis.
Hironaka T, Takizawa N, Yamauchi Y, Horii Y, Nakaya M
The Journal of biological chemistry 2023 Mar;299(3):102934
The Journal of biological chemistry 2023 Mar;299(3):102934
SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes.
Zheng W, Chen Q, Liu H, Zeng L, Zhou Y, Liu X, Bai Y, Zhang J, Pan Y, Shao C
Autophagy 2023 Mar;19(3):839-857
Autophagy 2023 Mar;19(3):839-857
Erxian decoction alleviates cisplatin-induced premature ovarian failure in rats by reducing oxidation levels in ovarian granulosa cells.
Liu J, Yang Y, He Y, Feng C, Ou H, Yang J, Chen Y, You F, Shao B, Bao J, Guan X, Chen F, Zhao P
Journal of ethnopharmacology 2023 Mar 25;304:116046
Journal of ethnopharmacology 2023 Mar 25;304:116046
Proliferating cell nuclear antigen impairs the nuclear import of influenza A virus PB2 and suppresses virus replication.
Zhou Y, Zhang S, Wang B, Ran Y, Tu S, Lin Z, Jin M, Chen H, Zou J, Zhou H
Journal of medical virology 2023 Jun;95(6):e28849
Journal of medical virology 2023 Jun;95(6):e28849
LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer.
Dey G, Bharti R, Braley C, Alluri R, Esakov E, Crean-Tate K, McCrae K, Joehlin-Price A, Rose PG, Lathia J, Gong Z, Reizes O
Journal of ovarian research 2023 Jun 27;16(1):122
Journal of ovarian research 2023 Jun 27;16(1):122
USP28 controls SREBP2 and the mevalonate pathway to drive tumour growth in squamous cancer.
Maier CR, Hartmann O, Prieto-Garcia C, Al-Shami KM, Schlicker L, Vogel FCE, Haid S, Klann K, Buck V, Münch C, Schmitz W, Einig E, Krenz B, Calzado MA, Eilers M, Popov N, Rosenfeldt MT, Diefenbacher ME, Schulze A
Cell death and differentiation 2023 Jul;30(7):1710-1725
Cell death and differentiation 2023 Jul;30(7):1710-1725
LAP1 supports nuclear adaptability during constrained melanoma cell migration and invasion.
Jung-Garcia Y, Maiques O, Monger J, Rodriguez-Hernandez I, Fanshawe B, Domart MC, Renshaw MJ, Marti RM, Matias-Guiu X, Collinson LM, Sanz-Moreno V, Carlton JG
Nature cell biology 2023 Jan;25(1):108-119
Nature cell biology 2023 Jan;25(1):108-119
Alternative transcribed 3' isoform of long non-coding RNA Malat1 inhibits mouse retinal oxidative stress.
Ghanam AR, Ke S, Wang S, Elgendy R, Xie C, Wang S, Zhang R, Wei M, Liu W, Cao J, Zhang Y, Zhang Z, Xue T, Zheng Y, Song X
iScience 2023 Jan 20;26(1):105740
iScience 2023 Jan 20;26(1):105740
Cerium Oxide Nanoparticles Promote Osteoplastic Precursor Differentiation by Activating the Wnt Pathway.
Luo J, Zhu S, Tong Y, Zhang Y, Li Y, Cao L, Kong M, Luo M, Bi Q, Zhang Q
Biological trace element research 2023 Feb;201(2):865-873
Biological trace element research 2023 Feb;201(2):865-873
Characterization of huntingtin interactomes and their dynamic responses in living cells by proximity proteomics.
Xu H, Bensalel J, Raju S, Capobianco E, Lu ML, Wei J
Journal of neurochemistry 2023 Feb;164(4):512-528
Journal of neurochemistry 2023 Feb;164(4):512-528
Upregulation of autotaxin by oxidative stress via Nrf2 activation: A novel insight into the compensation mechanism in preeclamptic placenta.
Yanagisawa M, Nagamatsu T, Kurano M, Misumi F, Taguchi A, Akiba N, Ichinose M, Kumasawa K, Iriyama T, Fujii T, Yatomi Y, Osuga Y
Journal of reproductive immunology 2023 Dec;160:104153
Journal of reproductive immunology 2023 Dec;160:104153
FHL2 Inhibits SARS-CoV-2 Replication by Enhancing IFN-β Expression through Regulating IRF-3.
Xu Z, Tian M, Tan Q, Hao P, Gao Z, Li C, Jin N
International journal of molecular sciences 2023 Dec 26;25(1)
International journal of molecular sciences 2023 Dec 26;25(1)
High-Throughput, Low Background, and Wide-Field Microscopy by Flat-Field Photobleaching Imprinting Microscopy.
Qin Y, Zhang M, Hao H, Xue B, Niu J, Sun Y
Chemical & biomedical imaging 2023 Dec 25;1(9):843-851
Chemical & biomedical imaging 2023 Dec 25;1(9):843-851
ROR1/STAT3 positive feedback loop facilitates cartilage degeneration in Osteoarthritis through activation of NF-κB signaling pathway.
Huang W, Tang H, Liu Y, Li W, Shimu AS, Li B, Zhu C
International immunopharmacology 2023 Aug;121:110433
International immunopharmacology 2023 Aug;121:110433
A Novel Transgenic Mouse Model Implicates Sirt2 as a Promoter of Hepatocellular Carcinoma.
Schmidt AV, Monga SP, Prochownik EV, Goetzman ES
International journal of molecular sciences 2023 Aug 9;24(16)
International journal of molecular sciences 2023 Aug 9;24(16)
An oncogenic isoform of septin 9 promotes the formation of juxtanuclear invadopodia by reducing nuclear deformability.
Okletey J, Angelis D, Jones TM, Montagna C, Spiliotis ET
Cell reports 2023 Aug 29;42(8):112893
Cell reports 2023 Aug 29;42(8):112893
XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility.
Kuang M, Zhao Y, Yu H, Li S, Liu T, Chen L, Chen J, Luo Y, Guo X, Wei X, Li Y, Zhang Z, Wang D, You F
Science advances 2023 Aug 18;9(33):eadg5211
Science advances 2023 Aug 18;9(33):eadg5211
A small-molecule inhibitor of Keap1-Nrf2 interaction attenuates sepsis by selectively augmenting the antibacterial defence of macrophages at infection sites.
Wang Y, Tang B, Li H, Zheng J, Zhang C, Yang Z, Tan X, Luo P, Ma L, Wang Y, Long L, Chen Z, Xiao Z, Ma L, Zhou J, Wang Y, Shi C
EBioMedicine 2023 Apr;90:104480
EBioMedicine 2023 Apr;90:104480
HnRNP K reduces viral gene expression by targeting cytosine-rich sequences in porcine reproductive and respiratory syndrome virus-2 genome to dampen the viral growth.
Jing H, Song Y, Li H, Duan E, Liu J, Ke W, Tao R, Li Y, Zhao P, Wang J, Cao S, Wang H, Sun Y, Zhang Y
Virology 2023 Apr;581:15-25
Virology 2023 Apr;581:15-25
E2F1-mediated ectopic expression of PP1A promotes breast cancer progression via activation of YAP1.
Deng X, Hua K, Munankarmy A, Luo Q, Wang X, Fang L
The international journal of biochemistry & cell biology 2023 Apr;157:106389
The international journal of biochemistry & cell biology 2023 Apr;157:106389
ZSWIM1 Promotes the Proliferation and Metastasis of Lung Adenocarcinoma Cells through the STK38/MEKK2/ERK1/2 Axis.
Gao X, Lian Q, Guan B, Liu QY, Meng M, Chen Y, Jin J, Li H, Liu X, Sun Z, Liu L, He QY, Zhang G
Journal of proteome research 2023 Apr 7;22(4):1080-1091
Journal of proteome research 2023 Apr 7;22(4):1080-1091
CircRNF10-DHX15 interaction suppressed breast cancer progression by antagonizing DHX15-NF-κB p65 positive feedback loop.
Zheng W, Wang X, Yu Y, Ji C, Fang L
Cellular & molecular biology letters 2023 Apr 26;28(1):34
Cellular & molecular biology letters 2023 Apr 26;28(1):34
Progerinin, an Inhibitor of Progerin, Alleviates Cardiac Abnormalities in a Model Mouse of Hutchinson-Gilford Progeria Syndrome.
Kang SM, Seo S, Song EJ, Kweon O, Jo AH, Park S, Woo TG, Kim BH, Oh GT, Park BJ
Cells 2023 Apr 24;12(9)
Cells 2023 Apr 24;12(9)
Metabolomics of clinical samples reveal the treatment mechanism of lanthanum hydroxide on vascular calcification in chronic kidney disease.
Gu C, Gao Y, Han R, Guo M, Liu H, Gao J, Liu Y, Li B, Sun L, Bu R, Liu Y, Hao J, Meng Y, An M, Cao X, Su C, Li G
Proceedings of the Japan Academy. Series B, Physical and biological sciences 2022;98(7):361-377
Proceedings of the Japan Academy. Series B, Physical and biological sciences 2022;98(7):361-377
Caspase-1-mediated extracellular vesicles derived from pyroptotic alveolar macrophages promote inflammation in acute lung injury.
Qin X, Zhou Y, Jia C, Chao Z, Qin H, Liang J, Liu X, Liu Z, Sun T, Yuan Y, Zhang H
International journal of biological sciences 2022;18(4):1521-1538
International journal of biological sciences 2022;18(4):1521-1538
Mouse Ocilrp2/Clec2i negatively regulates LPS-mediated IL-6 production by blocking Dap12-Syk interaction in macrophage.
Cao M, Ma L, Yan C, Wang H, Ran M, Chen Y, Wang X, Liang X, Chai L, Li X
Frontiers in immunology 2022;13:984520
Frontiers in immunology 2022;13:984520
Metformin Ameliorates Chronic Colitis-Related Intestinal Fibrosis via Inhibiting TGF-β1/Smad3 Signaling.
Wang Y, Wang Z, Yang H, Chen S, Zheng D, Liu X, Jiang Q, Chen Y
Frontiers in pharmacology 2022;13:887497
Frontiers in pharmacology 2022;13:887497
Suberoylanilide Hydroxamic Acid (SAHA) Treatment Reveals Crosstalk Among Proteome, Phosphoproteome, and Acetylome in Nasopharyngeal Carcinoma Cells.
Huang H, Fu Y, Duan Y, Zhang Y, Lu M, Chen Z, Li M, Chen Y
Frontiers in genetics 2022;13:873840
Frontiers in genetics 2022;13:873840
Keratin 17 Promotes T Cell Response in Allergic Contact Dermatitis by Upregulating C-C Motif Chemokine Ligand 20.
Luo Y, Zhu Z, Li B, Bai X, Fang H, Qiao P, Chen J, Zhang C, Zhi D, Dang E, Wang G
Frontiers in immunology 2022;13:764793
Frontiers in immunology 2022;13:764793
Nrf2 Overexpression Decreases Vincristine Chemotherapy Sensitivity Through the PI3K-AKT Pathway in Adult B-Cell Acute Lymphoblastic Leukemia.
Wang L, Liu X, Kang Q, Pan C, Zhang T, Feng C, Chen L, Wei S, Wang J
Frontiers in oncology 2022;12:876556
Frontiers in oncology 2022;12:876556
AKR1B10 accelerates the production of proinflammatory cytokines via the NF-κB signaling pathway in colon cancer.
Liu C, Shi L, Li W, Huang Z, Wang S, Xu P, Li T, Li Z, Luo F, Li W, Yan J, Wu T
Journal of molecular histology 2022 Oct;53(5):781-791
Journal of molecular histology 2022 Oct;53(5):781-791
Deletion of Smurf1 attenuates liver steatosis via stabilization of p53.
Lin W, Zhang X, Zhang C, Li L, Zhang J, Xie P, Zhan Y, An W
Laboratory investigation; a journal of technical methods and pathology 2022 Oct;102(10):1075-1087
Laboratory investigation; a journal of technical methods and pathology 2022 Oct;102(10):1075-1087
Synaptic proteomics reveal distinct molecular signatures of cognitive change and C9ORF72 repeat expansion in the human ALS cortex.
Laszlo ZI, Hindley N, Sanchez Avila A, Kline RA, Eaton SL, Lamont DJ, Smith C, Spires-Jones TL, Wishart TM, Henstridge CM
Acta neuropathologica communications 2022 Oct 29;10(1):156
Acta neuropathologica communications 2022 Oct 29;10(1):156
MCM2 promotes the stemness and sorafenib resistance of hepatocellular carcinoma cells via hippo signaling.
Zhou X, Luo J, Xie H, Wei Z, Li T, Liu J, Liao X, Zhu G, Peng T
Cell death discovery 2022 Oct 15;8(1):418
Cell death discovery 2022 Oct 15;8(1):418
Targeting epiregulin in the treatment-damaged tumor microenvironment restrains therapeutic resistance.
Wang C, Long Q, Fu Q, Xu Q, Fu D, Li Y, Gao L, Guo J, Zhang X, Lam EW, Campisi J, Sun Y
Oncogene 2022 Nov;41(45):4941-4959
Oncogene 2022 Nov;41(45):4941-4959
Disturbing NLRP3 acetylation and inflammasome assembly inhibits androgen receptor-promoted inflammatory responses and prostate cancer progression.
Zhao AN, Yang Z, Wang DD, Shi B, Zhang H, Bai Y, Yan BW, Zhang Y, Wen JK, Wang XL, Qu CB
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22602
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22602
Olfactory marker protein contains a leucine-rich domain in the Ω-loop important for nuclear export.
Nakashima N, Nakashima A, Nakashima K, Takano M
Molecular brain 2022 Nov 4;15(1):89
Molecular brain 2022 Nov 4;15(1):89
Activation of Nrf2 modulates protective immunity against Mycobacterium tuberculosis infection in THP1-derived macrophages.
Zhou J, Fang F, Qi J, Li T, Zhang L, Liu H, Lv J, Xu T, Wu F, Song C, Li W, Wang X, Chang X, Wang H, Wang T, Qian Z
Free radical biology & medicine 2022 Nov 20;193(Pt 1):177-189
Free radical biology & medicine 2022 Nov 20;193(Pt 1):177-189
SETDB1 fuels the lung cancer phenotype by modulating epigenome, 3D genome organization and chromatin mechanical properties.
Zakharova VV, Magnitov MD, Del Maestro L, Ulianov SV, Glentis A, Uyanik B, Williart A, Karpukhina A, Demidov O, Joliot V, Vassetzky YS, Mège RM, Piel M, Razin SV, Ait-Si-Ali S
Nucleic acids research 2022 May 6;50(8):4389-4413
Nucleic acids research 2022 May 6;50(8):4389-4413
Lactylation-driven METTL3-mediated RNA m(6)A modification promotes immunosuppression of tumor-infiltrating myeloid cells.
Xiong J, He J, Zhu J, Pan J, Liao W, Ye H, Wang H, Song Y, Du Y, Cui B, Xue M, Zheng W, Kong X, Jiang K, Ding K, Lai L, Wang Q
Molecular cell 2022 May 5;82(9):1660-1677.e10
Molecular cell 2022 May 5;82(9):1660-1677.e10
Cell-Penetrating Peptide TAT-HuR-HNS3 Suppresses Proinflammatory Gene Expression via Competitively Blocking Interaction of HuR with Its Partners.
Wang K, Tong H, Gao Y, Xia L, Jin X, Li X, Zeng X, Boldogh I, Ke Y, Ba X
Journal of immunology (Baltimore, Md. : 1950) 2022 May 15;208(10):2376-2389
Journal of immunology (Baltimore, Md. : 1950) 2022 May 15;208(10):2376-2389
Highly efficient A-to-G base editing by ABE8.17 in rabbits.
Zhao D, Qian Y, Li J, Li Z, Lai L
Molecular therapy. Nucleic acids 2022 Mar 8;27:1156-1163
Molecular therapy. Nucleic acids 2022 Mar 8;27:1156-1163
p62 Promotes the Mitochondrial Localization of p53 through Its UBA Domain and Participates in Regulating the Sensitivity of Ovarian Cancer Cells to Cisplatin.
Kong Q, Yan X, Cheng M, Jiang X, Xu L, Shen L, Yu H, Sun L
International journal of molecular sciences 2022 Mar 18;23(6)
International journal of molecular sciences 2022 Mar 18;23(6)
Rapid and robust derivation of mesenchymal stem cells from human pluripotent stem cells via temporal induction of neuralized ectoderm.
Jin W, He Y, Li T, Long F, Qin X, Yuan Y, Gao G, Shakhawat HM, Liu X, Jin G, Zhou Z
Cell & bioscience 2022 Mar 15;12(1):31
Cell & bioscience 2022 Mar 15;12(1):31
Multiple PDE3A modulators act as molecular glues promoting PDE3A-SLFN12 interaction and induce SLFN12 dephosphorylation and cell death.
Yan B, Ding Z, Zhang W, Cai G, Han H, Ma Y, Cao Y, Wang J, Chen S, Ai Y
Cell chemical biology 2022 Jun 16;29(6):958-969.e5
Cell chemical biology 2022 Jun 16;29(6):958-969.e5
Loss of perinuclear theca ACTRT1 causes acrosome detachment and severe male subfertility in mice.
Zhang XZ, Wei LL, Zhang XH, Jin HJ, Chen SR
Development (Cambridge, England) 2022 Jun 15;149(12)
Development (Cambridge, England) 2022 Jun 15;149(12)
The perinuclear theca protein Calicin helps shape the sperm head and maintain the nuclear structure in mice.
Zhang XZ, Wei LL, Jin HJ, Zhang XH, Chen SR
Cell reports 2022 Jul 5;40(1):111049
Cell reports 2022 Jul 5;40(1):111049
A novel homozygous missense mutation in AK7 causes multiple morphological anomalies of the flagella and oligoasthenoteratozoospermia.
Xiang M, Wang Y, Xu W, Zheng N, Deng H, Zhang J, Duan Z, Zha X, Zhang W, Song G, Shi X, Wang F, Cao Y, Zhu F
Journal of assisted reproduction and genetics 2022 Jan;39(1):261-266
Journal of assisted reproduction and genetics 2022 Jan;39(1):261-266
MITF activity is regulated by a direct interaction with RAF proteins in melanoma cells.
Estrada C, Mirabal-Ortega L, Méry L, Dingli F, Besse L, Messaoudi C, Loew D, Pouponnot C, Bertolotto C, Eychène A, Druillennec S
Communications biology 2022 Jan 28;5(1):101
Communications biology 2022 Jan 28;5(1):101
Static Magnetic Fields Reduce Oxidative Stress to Improve Wound Healing and Alleviate Diabetic Complications.
Feng C, Yu B, Song C, Wang J, Zhang L, Ji X, Wang Y, Fang Y, Liao Z, Wei M, Zhang X
Cells 2022 Jan 27;11(3)
Cells 2022 Jan 27;11(3)
RICH1 inhibits breast cancer stem cell traits through activating kinases cascade of Hippo signaling by competing with Merlin for binding to Amot-p80.
Tian Q, Gao H, Zhou Y, Zhu L, Yang J, Wang B, Liu P, Yang J
Cell death & disease 2022 Jan 21;13(1):71
Cell death & disease 2022 Jan 21;13(1):71
Inhibition of high-fat diet-induced obesity via reduction of ER-resident protein Nogo occurs through multiple mechanisms.
Wang X, Yang Y, Zhao D, Zhang S, Chen Y, Chen Y, Feng K, Li X, Han J, Iwakiri Y, Duan Y, Yang X
The Journal of biological chemistry 2022 Feb;298(2):101561
The Journal of biological chemistry 2022 Feb;298(2):101561
Novel Mutation and Deletion in SUN5 Cause Male Infertility with Acephalic Spermatozoa Syndrome.
Xiang M, Wang Y, Wang K, Kong S, Lu M, Zhang J, Duan Z, Zha X, Shi X, Wang F, Cao Y, Zhu F
Reproductive sciences (Thousand Oaks, Calif.) 2022 Feb;29(2):646-651
Reproductive sciences (Thousand Oaks, Calif.) 2022 Feb;29(2):646-651
Inhibition of FOXO1‑mediated autophagy promotes paclitaxel‑induced apoptosis of MDA‑MB‑231 cells.
Xu K, Zhu W, Xu A, Xiong Z, Zou D, Zhao H, Jiao D, Qing Y, Jamal MA, Wei HJ, Zhao HY
Molecular medicine reports 2022 Feb;25(2)
Molecular medicine reports 2022 Feb;25(2)
HDAC9 Contributes to Serous Ovarian Cancer Progression through Regulating Epithelial-Mesenchymal Transition.
Xu L, Wang J, Liu B, Fu J, Zhao Y, Yu S, Shen L, Yan X, Su J
Biomedicines 2022 Feb 3;10(2)
Biomedicines 2022 Feb 3;10(2)
miR-376a-3p and miR-376b-3p overexpression in Hutchinson-Gilford progeria fibroblasts inhibits cell proliferation and induces premature senescence.
Frankel D, Delecourt V, Novoa-Del-Toro EM, Robin JD, Airault C, Bartoli C, Carabalona A, Perrin S, Mazaleyrat K, De Sandre-Giovannoli A, Magdinier F, Baudot A, Lévy N, Kaspi E, Roll P
iScience 2022 Feb 18;25(2):103757
iScience 2022 Feb 18;25(2):103757
Substrate rigidity dictates colorectal tumorigenic cell stemness and metastasis via CRAD-dependent mechanotransduction.
Chang Y, Zhang J, Huo X, Qu X, Xia C, Huang K, Xie F, Wang N, Wei X, Jia Q
Cell reports 2022 Feb 15;38(7):110390
Cell reports 2022 Feb 15;38(7):110390
Qushi Huayu decoction attenuated hepatic lipid accumulation via JAK2/STAT3/CPT-1A-related fatty acid β-oxidation in mice with non-alcoholic steatohepatitis.
Sun Q, Wang X, Xin X, An Z, Hu Y, Feng Q
Pharmaceutical biology 2022 Dec;60(1):2124-2133
Pharmaceutical biology 2022 Dec;60(1):2124-2133
Loss of Mature Lamin A/C Triggers a Shift in Intracellular Metabolic Homeostasis via AMPKα Activation.
Zhou Y, Yang JJ, Cheng Y, Feng GX, Yang RH, Yuan Y, Wang LY, Wang M, Kong L
Cells 2022 Dec 9;11(24)
Cells 2022 Dec 9;11(24)
Tetrahydroxy Stilbene Glucoside Alleviates Ischemic Stroke by Regulating Conformation-Dependent Intracellular Distribution of PKM2 for M2 Macrophage Polarization.
Li M, Lu W, Meng Y, Zhang W, Wang F, Sun L, Xu Y
Journal of agricultural and food chemistry 2022 Dec 14;70(49):15449-15463
Journal of agricultural and food chemistry 2022 Dec 14;70(49):15449-15463
Hsa_circ_0005050 interacts with ILF3 and affects cell apoptosis and proliferation by disrupting the balance between p53 and p65.
Tan J, Sun M, Yin J, Zhou Q, Zhao R, Chen Q, Sun H, Jiang C, Li S, He Y
Chemico-biological interactions 2022 Dec 1;368:110208
Chemico-biological interactions 2022 Dec 1;368:110208
Lanthanum hydroxide inhibits vascular calcification by regulating the HIF-1 pathway.
Wang S, Zhao L, Liu H, Han R, Liu Y, Gao J, Bu R, Li B, Sun L, Hao J, Zhao J, Li G
Cell biology international 2022 Aug;46(8):1275-1287
Cell biology international 2022 Aug;46(8):1275-1287
Irradiation combined with PD-L1(-/-) and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING-mediated T cell activation.
Zhao X, Hu S, Zeng L, Liu X, Song Y, Zhang Y, Chen Q, Bai Y, Zhang J, Zhang H, Pan Y, Shao C
iScience 2022 Aug 19;25(8):104690
iScience 2022 Aug 19;25(8):104690
Global crotonylome reveals hypoxia-mediated lamin A crotonylation regulated by HDAC6 in liver cancer.
Zhang D, Tang J, Xu Y, Huang X, Wang Y, Jin X, Wu G, Liu P
Cell death & disease 2022 Aug 17;13(8):717
Cell death & disease 2022 Aug 17;13(8):717
BRCA2 promoter hypermethylation as a biomarker for the leukemic transformation of myeloproliferative neoplasms.
Yang C, Zhang Q, Tang X, Wang B, Guan M, Tang G, Wu Z
Epigenomics 2022 Apr;14(7):391-403
Epigenomics 2022 Apr;14(7):391-403
The Pharmacological Effect and Mechanism of Lanthanum Hydroxide on Vascular Calcification Caused by Chronic Renal Failure Hyperphosphatemia.
Zhao L, Wang S, Liu H, Du X, Bu R, Li B, Han R, Gao J, Liu Y, Hao J, Zhao J, Meng Y, Li G
Frontiers in cell and developmental biology 2021;9:639127
Frontiers in cell and developmental biology 2021;9:639127
Folic Acid Protects Melanocytes from Oxidative Stress via Activation of Nrf2 and Inhibition of HMGB1.
Du P, Zhang S, Li S, Yang Y, Kang P, Chen J, Gao T, Li C, Zhang Q, Zhang W
Oxidative medicine and cellular longevity 2021;2021:1608586
Oxidative medicine and cellular longevity 2021;2021:1608586
Hepatitis B Surface Antigen Suppresses the Activation of Nuclear Factor Kappa B Pathway via Interaction With the TAK1-TAB2 Complex.
Deng F, Xu G, Cheng Z, Huang Y, Ma C, Luo C, Yu C, Wang J, Xu X, Liu S, Zhu Y
Frontiers in immunology 2021;12:618196
Frontiers in immunology 2021;12:618196
Autophagy-Induced HDAC6 Activity During Hypoxia Regulates Mitochondrial Energy Metabolism Through the β-Catenin/COUP-TFII Axis in Hepatocellular Carcinoma Cells.
Yan X, Qu X, Liu B, Zhao Y, Xu L, Yu S, Wang J, Wang L, Su J
Frontiers in oncology 2021;11:742460
Frontiers in oncology 2021;11:742460
miR-1258 Attenuates Tumorigenesis Through Targeting E2F1 to Inhibit PCNA and MMP2 Transcription in Glioblastoma.
Qin H, Gui Y, Ma R, Zhang H, Guo Y, Ye Y, Li J, Zhao L, Wang Y
Frontiers in oncology 2021;11:671144
Frontiers in oncology 2021;11:671144
Adipocyte-Specific Deletion of Lamin A/C Largely Models Human Familial Partial Lipodystrophy Type 2.
Corsa CAS, Walsh CM, Bagchi DP, Foss Freitas MC, Li Z, Hardij J, Granger K, Mori H, Schill RL, Lewis KT, Maung JN, Azaria RD, Rothberg AE, Oral EA, MacDougald OA
Diabetes 2021 Sep;70(9):1970-1984
Diabetes 2021 Sep;70(9):1970-1984
Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing.
Zhang Q, Zhang J, Ye J, Li X, Liu H, Ma X, Wang C, He K, Zhang W, Yuan J, Zhao Y, Xu H, Liu Q
Molecular neurodegeneration 2021 Sep 22;16(1):66
Molecular neurodegeneration 2021 Sep 22;16(1):66
Long non-coding RNA NR2F1-AS1 induces breast cancer lung metastatic dormancy by regulating NR2F1 and ΔNp63.
Liu Y, Zhang P, Wu Q, Fang H, Wang Y, Xiao Y, Cong M, Wang T, He Y, Ma C, Tian P, Liang Y, Qin LX, Yang Q, Yang Q, Liao L, Hu G
Nature communications 2021 Sep 2;12(1):5232
Nature communications 2021 Sep 2;12(1):5232
The Retinoblastoma Tumor Suppressor Is Required for the NUP98-HOXA9-Induced Aberrant Nuclear Envelope Phenotype.
Vaz M, Fahrenkrog B
Cells 2021 Oct 22;10(11)
Cells 2021 Oct 22;10(11)
Bortezomib potentiates antitumor activity of mitoxantrone through dampening Wnt/β-catenin signal pathway in prostate cancer cells.
Zhang Y, Liu Q, Wei W, Zhang G, Yan S, Dai R, Sun Y, Su D, Lv S, Xia Y, Li J, Li C
BMC cancer 2021 Oct 13;21(1):1101
BMC cancer 2021 Oct 13;21(1):1101
Arsenic trioxide induces expression of BCL-2 expression via NF-κB and p38 MAPK signaling pathways in BEAS-2B cells during apoptosis.
Tang J, Yao C, Liu Y, Yuan J, Wu L, Hosoi K, Yu S, Huang C, Wei H, Chen G
Ecotoxicology and environmental safety 2021 Oct 1;222:112531
Ecotoxicology and environmental safety 2021 Oct 1;222:112531
HSD17B6 downregulation predicts poor prognosis and drives tumor progression via activating Akt signaling pathway in lung adenocarcinoma.
Tian T, Hong F, Wang Z, Hu J, Chen N, Lv L, Yi Q
Cell death discovery 2021 Nov 8;7(1):341
Cell death discovery 2021 Nov 8;7(1):341
The miR-378c-Samd1 circuit promotes phenotypic modulation of vascular smooth muscle cells and foam cells formation in atherosclerosis lesions.
Tian S, Cao Y, Wang J, Bi Y, Zhong J, Meng X, Sun W, Yang R, Gan L, Wang X, Li H, Wang R
Scientific reports 2021 May 18;11(1):10548
Scientific reports 2021 May 18;11(1):10548
The role of LR-TIMAP/PP1c complex in the occurrence and development of no-reflow.
Quan X, Liu X, Qin X, Wang Y, Sun T, Li Z, Zhu L, Chen J, Zhou Y, Singh S, Dong H, Zhang Z, Zhang H
EBioMedicine 2021 Mar;65:103251
EBioMedicine 2021 Mar;65:103251
EEF1A2 interacts with HSP90AB1 to promote lung adenocarcinoma metastasis via enhancing TGF-β/SMAD signalling.
Jia L, Ge X, Du C, Chen L, Zhou Y, Xiong W, Xiang J, Li G, Xiao G, Fang L, Li Z
British journal of cancer 2021 Mar;124(7):1301-1311
British journal of cancer 2021 Mar;124(7):1301-1311
Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway.
Gao X, Wang Y, Lu F, Chen X, Yang D, Cao Y, Zhang W, Chen J, Zheng L, Wang G, Fu M, Ma L, Song Y, Zhan Q
Journal of extracellular vesicles 2021 Mar;10(5):e12060
Journal of extracellular vesicles 2021 Mar;10(5):e12060
Virus-inducible IGFALS facilitates innate immune responses by mediating IRAK1 and TRAF6 activation.
Xu G, Deng F, Zuo Q, Liu L, Dou K, Cheng Z, Cao W, Luo C, Yu C, Liu S, Zhu Y
Cellular & molecular immunology 2021 Jun;18(6):1587-1589
Cellular & molecular immunology 2021 Jun;18(6):1587-1589
Formin-like protein 2 promotes cell proliferation by a p27-related mechanism in human breast cancer cells.
Jiao X, Wang B, Feng C, Song S, Tian B, Zhou C, Gao X, Sun W, Liu P
BMC cancer 2021 Jun 30;21(1):760
BMC cancer 2021 Jun 30;21(1):760
Inducible ATP1B1 Upregulates Antiviral Innate Immune Responses by the Ubiquitination of TRAF3 and TRAF6.
Cao W, Guo Y, Cheng Z, Xu G, Zuo Q, Nie L, Huang Y, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2021 Jun 1;206(11):2668-2681
Journal of immunology (Baltimore, Md. : 1950) 2021 Jun 1;206(11):2668-2681
Cryptotanshinone, a novel PDK 4 inhibitor, suppresses bladder cancer cell invasiveness via the mTOR/β‑catenin/N‑cadherin axis.
Kim CJ, Terado T, Tambe Y, Mukaisho KI, Kageyama S, Kawauchi A, Inoue H
International journal of oncology 2021 Jul;59(1)
International journal of oncology 2021 Jul;59(1)
Cimigenoside functions as a novel γ-secretase inhibitor and inhibits the proliferation or metastasis of human breast cancer cells by γ-secretase/Notch axis.
Jia H, Liu M, Wang X, Jiang Q, Wang S, Santhanam RK, Lv C, Zhao Q, Lu J
Pharmacological research 2021 Jul;169:105686
Pharmacological research 2021 Jul;169:105686
Role of IL-6-IL-27 Complex in Host Antiviral Immune Response.
Zuo Q, Cheng Z, Zhang G, Xia Y, Xu G, Cao W, Yang X, Fu Y, He R, Fang P, Guo Y, Nie L, Huang Y, Liu L, Zhan J, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2021 Jul 15;207(2):577-589
Journal of immunology (Baltimore, Md. : 1950) 2021 Jul 15;207(2):577-589
Nuclear Factor-κB Signaling Mediates Antimony-induced Astrocyte Activation.
Zhang T, Zheng YD, Jiao M, Zhi Y, Xu SY, Zhu PY, Zhao XY, Wu QY
Biomedical and environmental sciences : BES 2021 Jan 20;34(1):29-39
Biomedical and environmental sciences : BES 2021 Jan 20;34(1):29-39
Hsa_circ_0005273 facilitates breast cancer tumorigenesis by regulating YAP1-hippo signaling pathway.
Wang X, Ji C, Hu J, Deng X, Zheng W, Yu Y, Hua K, Zhou X, Fang L
Journal of experimental & clinical cancer research : CR 2021 Jan 12;40(1):29
Journal of experimental & clinical cancer research : CR 2021 Jan 12;40(1):29
Syndecan 4 contributes to osteoclast differentiation induced by RANKL through enhancing autophagy.
Li J, Sun Z, Lin Y, Yan Y, Yan H, Jing B, Han Z
International immunopharmacology 2021 Feb;91:107275
International immunopharmacology 2021 Feb;91:107275
Carnosic acid protects against ferroptosis in PC12 cells exposed to erastin through activation of Nrf2 pathway.
Cheng J, Xu T, Xun C, Guo H, Cao R, Gao S, Sheng W
Life sciences 2021 Feb 1;266:118905
Life sciences 2021 Feb 1;266:118905
Prenylated xanthones from mangosteen (Garcinia mangostana) activate the AhR and Nrf2 pathways and protect intestinal barrier integrity in HT-29 cells.
Tocmo R, Le B, Heun A, van Pijkeren JP, Parkin K, Johnson JJ
Free radical biology & medicine 2021 Feb 1;163:102-115
Free radical biology & medicine 2021 Feb 1;163:102-115
The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice.
Xu Q, Fu Q, Li Z, Liu H, Wang Y, Lin X, He R, Zhang X, Ju Z, Campisi J, Kirkland JL, Sun Y
Nature metabolism 2021 Dec;3(12):1706-1726
Nature metabolism 2021 Dec;3(12):1706-1726
hsa_circ_0068631 promotes breast cancer progression through c-Myc by binding to EIF4A3.
Wang X, Chen M, Fang L
Molecular therapy. Nucleic acids 2021 Dec 3;26:122-134
Molecular therapy. Nucleic acids 2021 Dec 3;26:122-134
Ferroptosis inducer erastin sensitizes NSCLC cells to celastrol through activation of the ROS-mitochondrial fission-mitophagy axis.
Liu M, Fan Y, Li D, Han B, Meng Y, Chen F, Liu T, Song Z, Han Y, Huang L, Chang Y, Cao P, Nakai A, Tan K
Molecular oncology 2021 Aug;15(8):2084-2105
Molecular oncology 2021 Aug;15(8):2084-2105
AKR1B10 negatively regulates autophagy through reducing GAPDH upon glucose starvation in colon cancer.
Li W, Liu C, Huang Z, Shi L, Zhong C, Zhou W, Meng P, Li Z, Wang S, Luo F, Yan J, Wu T
Journal of cell science 2021 Apr 15;134(8)
Journal of cell science 2021 Apr 15;134(8)
Epiregulin (EREG) and Myocardin Related Transcription Factor A (MRTF-A) Form a Feedforward Loop to Drive Hepatic Stellate Cell Activation.
Wu X, Dong W, Zhang T, Ren H, Wang J, Shang L, Zhu Z, Zhu W, Shi X, Xu Y
Frontiers in cell and developmental biology 2020;8:591246
Frontiers in cell and developmental biology 2020;8:591246
Heme Oxygenase-1 Suppresses Wnt Signaling Pathway in Nonalcoholic Steatohepatitis-Related Liver Fibrosis.
Du J, Ren W, Zhang Q, Fu N, Han F, Cui P, Li W, Kong L, Zhao S, Wang R, Zhang Y, Yang L, Kong L, Nan Y
BioMed research international 2020;2020:4910601
BioMed research international 2020;2020:4910601
Single-cell RNA-sequencing analysis identifies host long noncoding RNA MAMDC2-AS1 as a co-factor for HSV-1 nuclear transport.
Wang Y, Huang L, Wang Y, Luo W, Li F, Xiao J, Qin S, Wang Z, Song X, Wang Y, Jin F, Wang Y
International journal of biological sciences 2020;16(9):1586-1603
International journal of biological sciences 2020;16(9):1586-1603
Hepatitis B Core Antigen Impairs the Polarization While Promoting the Production of Inflammatory Cytokines of M2 Macrophages via the TLR2 Pathway.
Yi H, Zhang Y, Yang X, Li M, Hu H, Xiong J, Wang N, Jin J, Zhang Y, Song Y, Wang X, Chen L, Lian J
Frontiers in immunology 2020;11:535
Frontiers in immunology 2020;11:535
Nuclear pore blockade reveals that HIV-1 completes reverse transcription and uncoating in the nucleus.
Dharan A, Bachmann N, Talley S, Zwikelmaier V, Campbell EM
Nature microbiology 2020 Sep;5(9):1088-1095
Nature microbiology 2020 Sep;5(9):1088-1095
TL1A inhibits atherosclerosis in apoE-deficient mice by regulating the phenotype of vascular smooth muscle cells.
Zhao D, Li J, Xue C, Feng K, Liu L, Zeng P, Wang X, Chen Y, Li L, Zhang Z, Duan Y, Han J, Yang X
The Journal of biological chemistry 2020 Nov 27;295(48):16314-16327
The Journal of biological chemistry 2020 Nov 27;295(48):16314-16327
Inhibition of protein phosphatase methylesterase 1 dysregulates MAP kinase signaling and attenuates muscle cell differentiation.
Labuzan SA, Lynch SA, Cooper LM, Waddell DS
Gene 2020 May 20;739:144515
Gene 2020 May 20;739:144515
p62/SQSTM1 accumulation due to degradation inhibition and transcriptional activation plays a critical role in silica nanoparticle-induced airway inflammation via NF-κB activation.
Wu Y, Jin Y, Sun T, Zhu P, Li J, Zhang Q, Wang X, Jiang J, Chen G, Zhao X
Journal of nanobiotechnology 2020 May 19;18(1):77
Journal of nanobiotechnology 2020 May 19;18(1):77
Osteopetrosis-Associated Transmembrane Protein 1 Recruits RNA Exosome To Restrict Hepatitis B Virus Replication.
Ma C, Xu W, Yang Q, Liu W, Xiang Q, Chen J, Zhang Q, Liu Y, Wu K, Wu J
Journal of virology 2020 May 18;94(11)
Journal of virology 2020 May 18;94(11)
Overexpression of NRF1-742 or NRF1-772 Reduces Arsenic-Induced Cytotoxicity and Apoptosis in Human HaCaT Keratinocytes.
Wang S, Cheng H, Wang L, Zhao R, Guan D
International journal of molecular sciences 2020 Mar 16;21(6)
International journal of molecular sciences 2020 Mar 16;21(6)
Cytoplasmic PCNA is located in the actin belt and involved in osteoclast differentiation.
Tang D, Liu X, Chen K, Li Z, Dai Y, Xu J, Zhang HT, Gao X, Liu L
Aging 2020 Jun 27;12(13):13297-13317
Aging 2020 Jun 27;12(13):13297-13317
α-Ketoglutarate Modulates Macrophage Polarization Through Regulation of PPARγ Transcription and mTORC1/p70S6K Pathway to Ameliorate ALI/ARDS.
Liu M, Chen Y, Wang S, Zhou H, Feng D, Wei J, Shi X, Wu L, Zhang P, Yang H, Lv X
Shock (Augusta, Ga.) 2020 Jan;53(1):103-113
Shock (Augusta, Ga.) 2020 Jan;53(1):103-113
Translation Efficiency and Degradation of ER-Associated mRNAs Modulated by ER-Anchored poly(A)-Specific Ribonuclease (PARN).
Duan TL, Jiao H, He GJ, Yan YB
Cells 2020 Jan 9;9(1)
Cells 2020 Jan 9;9(1)
Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis.
Feng J, Dai W, Mao Y, Wu L, Li J, Chen K, Yu Q, Kong R, Li S, Zhang J, Ji J, Wu J, Mo W, Xu X, Guo C
Journal of experimental & clinical cancer research : CR 2020 Jan 30;39(1):24
Journal of experimental & clinical cancer research : CR 2020 Jan 30;39(1):24
SSEA3 and Sialyl Lewis a Glycan Expression Is Controlled by B3GALT5 LTR through Lamin A-NFYA and SIRT1-STAT3 Signaling in Human ES Cells.
Cai BH, Lee HY, Chou CK, Wu PH, Huang HC, Chao CC, Chung HY, Kannagi R
Cells 2020 Jan 10;9(1)
Cells 2020 Jan 10;9(1)
LL-37 restored glucocorticoid sensitivity impaired by virus dsRNA in lung.
Li K, Tao N, Zheng L, Sun T
International immunopharmacology 2020 Feb;79:106057
International immunopharmacology 2020 Feb;79:106057
Tissue-Resident Alveolar Macrophages Do Not Rely on Glycolysis for LPS-induced Inflammation.
Woods PS, Kimmig LM, Meliton AY, Sun KA, Tian Y, O'Leary EM, Gökalp GA, Hamanaka RB, Mutlu GM
American journal of respiratory cell and molecular biology 2020 Feb;62(2):243-255
American journal of respiratory cell and molecular biology 2020 Feb;62(2):243-255
SOX2 Represses Hepatitis B Virus Replication by Binding to the Viral EnhII/Cp and Inhibiting the Promoter Activation.
Yang H, Mo J, Xiang Q, Zhao P, Song Y, Yang G, Wu K, Liu Y, Liu W, Wu J
Viruses 2020 Feb 29;12(3)
Viruses 2020 Feb 29;12(3)
N-myc downstream-regulated gene 2 promotes the protein stability of estrogen receptor beta via inhibition of ubiquitin-protein ligase E3A to suppress colorectal cancer.
Zhu J, Lv Y, Hao J, Shi T, Wang S, Wang K, Fan X, Guo Y, Zhang J, Li J
Journal of gastrointestinal oncology 2020 Dec;11(6):1200-1213
Journal of gastrointestinal oncology 2020 Dec;11(6):1200-1213
SARS-CoV-2 Nucleocapsid Protein Interacts with RIG-I and Represses RIG-Mediated IFN-β Production.
Chen K, Xiao F, Hu D, Ge W, Tian M, Wang W, Pan P, Wu K, Wu J
Viruses 2020 Dec 30;13(1)
Viruses 2020 Dec 30;13(1)
Eukaryotic Translation Elongation Factor 1 Delta Inhibits the Nuclear Import of the Nucleoprotein and PA-PB1 Heterodimer of Influenza A Virus.
Gao Q, Yang C, Ren C, Zhang S, Gao X, Jin M, Chen H, Ma W, Zhou H
Journal of virology 2020 Dec 22;95(2)
Journal of virology 2020 Dec 22;95(2)
Torsin ATPases influence chromatin interaction of the Torsin regulator LAP1.
Luithle N, de Bos JU, Hovius R, Maslennikova D, Lewis RT, Ungricht R, Fierz B, Kutay U
eLife 2020 Dec 15;9
eLife 2020 Dec 15;9
Interplay of m(6)A and H3K27 trimethylation restrains inflammation during bacterial infection.
Wu C, Chen W, He J, Jin S, Liu Y, Yi Y, Gao Z, Yang J, Yang J, Cui J, Zhao W
Science advances 2020 Aug;6(34):eaba0647
Science advances 2020 Aug;6(34):eaba0647
Effects of mevalonate kinase interference on cell differentiation, apoptosis, prenylation and geranylgeranylation of human keratinocytes are attenuated by farnesyl pyrophosphate or geranylgeranyl pyrophosphate.
Li M, Min W, Wang J, Wang L, Li Y, Zhou N, Yang Z, Qian Q
Experimental and therapeutic medicine 2020 Apr;19(4):2861-2870
Experimental and therapeutic medicine 2020 Apr;19(4):2861-2870
HuR stabilizes HTT mRNA via interacting with its exon 11 in a mutant HTT-dependent manner.
Zhao Q, Li C, Yu M, Sun Y, Wang J, Ma L, Sun X, Lu B
RNA biology 2020 Apr;17(4):500-516
RNA biology 2020 Apr;17(4):500-516
The CDK inhibitor p57(Kip2) enhances the activity of the transcriptional coactivator FHL2.
Kullmann MK, Podmirseg SR, Roilo M, Hengst L
Scientific reports 2020 Apr 28;10(1):7140
Scientific reports 2020 Apr 28;10(1):7140
MiR-27a-regulated FOXO1 promotes pancreatic ductal adenocarcinoma cell progression by enhancing Wnt/β-catenin signaling activity.
Ling J, Dong X, Wang L, Xue Y, Jia X, Song W, Li Q
American journal of translational research 2019;11(5):3069-3080
American journal of translational research 2019;11(5):3069-3080
Inhibition of Influenza A Virus Replication by TRIM14 via Its Multifaceted Protein-Protein Interaction With NP.
Wu X, Wang J, Wang S, Wu F, Chen Z, Li C, Cheng G, Qin FX
Frontiers in microbiology 2019;10:344
Frontiers in microbiology 2019;10:344
miR‑494‑3p regulates lipopolysaccharide‑induced inflammatory responses in RAW264.7 cells by targeting PTEN.
Zhang S, He K, Zhou W, Cao J, Jin Z
Molecular medicine reports 2019 May;19(5):4288-4296
Molecular medicine reports 2019 May;19(5):4288-4296
PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma.
Feng J, Wu L, Ji J, Chen K, Yu Q, Zhang J, Chen J, Mao Y, Wang F, Dai W, Xu L, Wu J, Guo C
Journal of experimental & clinical cancer research : CR 2019 May 17;38(1):204
Journal of experimental & clinical cancer research : CR 2019 May 17;38(1):204
Lamin A mutation impairs interaction with nucleoporin NUP155 and disrupts nucleocytoplasmic transport in atrial fibrillation.
Han M, Zhao M, Cheng C, Huang Y, Han S, Li W, Tu X, Luo X, Yu X, Liu Y, Chen Q, Ren X, Wang QK, Ke T
Human mutation 2019 Mar;40(3):310-325
Human mutation 2019 Mar;40(3):310-325
Deficiency of heat shock protein A12A promotes browning of white adipose tissues in mice.
Cheng H, Qi T, Zhang X, Kong Q, Min X, Mao Q, Cao X, Liu L, Ding Z
Biochimica et biophysica acta. Molecular basis of disease 2019 Jun 1;1865(6):1451-1459
Biochimica et biophysica acta. Molecular basis of disease 2019 Jun 1;1865(6):1451-1459
YAP mediates the positive regulation of hnRNPK on the lung adenocarcinoma H1299 cell growth.
Xu L, Zhang T, Huang W, Liu X, Lu J, Gao X, Zhang YF, Liu L
Acta biochimica et biophysica Sinica 2019 Jul 10;51(7):677-687
Acta biochimica et biophysica Sinica 2019 Jul 10;51(7):677-687
JNK activation-mediated nuclear SIRT1 protein suppression contributes to silica nanoparticle-induced pulmonary damage via p53 acetylation and cytoplasmic localisation.
Zhao X, Wu Y, Li J, Li D, Jin Y, Zhu P, Liu Y, Zhuang Y, Yu S, Cao W, Wei H, Wang X, Han Y, Chen G
Toxicology 2019 Jul 1;423:42-53
Toxicology 2019 Jul 1;423:42-53
HSPA12A Is a Novel Player in Nonalcoholic Steatohepatitis via Promoting Nuclear PKM2-Mediated M1 Macrophage Polarization.
Kong Q, Li N, Cheng H, Zhang X, Cao X, Qi T, Dai L, Zhang Z, Chen X, Li C, Li Y, Xue B, Fang L, Liu L, Ding Z
Diabetes 2019 Feb;68(2):361-376
Diabetes 2019 Feb;68(2):361-376
Matrix stiffness mediates stemness characteristics via activating the Yes-associated protein in colorectal cancer cells.
Tan F, Huang Y, Pei Q, Liu H, Pei H, Zhu H
Journal of cellular biochemistry 2019 Feb;120(2):2213-2225
Journal of cellular biochemistry 2019 Feb;120(2):2213-2225
Angiomotin-p130 inhibits β-catenin stability by competing with Axin for binding to tankyrase in breast cancer.
Yang J, Zhang X, Chen Z, Shen Y, Wang F, Wang Y, Liu Y, Liu P, Yang J
Cell death & disease 2019 Feb 21;10(3):179
Cell death & disease 2019 Feb 21;10(3):179
HSF1 phosphorylation by cyclosporin A confers hyperthermia sensitivity through suppression of HSP expression.
Shao J, Han B, Cao P, Zhang B, Liu M, Li D, Zhou N, Hao Q, Duan X, Chang Y, Nakai A, Fan Y, Tan K
Biochimica et biophysica acta. Gene regulatory mechanisms 2019 Aug;1862(8):846-857
Biochimica et biophysica acta. Gene regulatory mechanisms 2019 Aug;1862(8):846-857
Inducible LGALS3BP/90K activates antiviral innate immune responses by targeting TRAF6 and TRAF3 complex.
Xu G, Xia Z, Deng F, Liu L, Wang Q, Yu Y, Wang F, Zhu C, Liu W, Cheng Z, Zhu Y, Zhou L, Zhang Y, Lu M, Liu S
PLoS pathogens 2019 Aug;15(8):e1008002
PLoS pathogens 2019 Aug;15(8):e1008002
CRABP2 regulates invasion and metastasis of breast cancer through hippo pathway dependent on ER status.
Feng X, Zhang M, Wang B, Zhou C, Mu Y, Li J, Liu X, Wang Y, Song Z, Liu P
Journal of experimental & clinical cancer research : CR 2019 Aug 16;38(1):361
Journal of experimental & clinical cancer research : CR 2019 Aug 16;38(1):361
NAC1 Potentiates Cellular Antiviral Signaling by Bridging MAVS and TBK1.
Xia Z, Xu G, Nie L, Liu L, Peng N, He Q, Zuo Q, Zhou Y, Cao Z, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2019 Aug 15;203(4):1001-1011
Journal of immunology (Baltimore, Md. : 1950) 2019 Aug 15;203(4):1001-1011
SKP2 Promotes Hepatocellular Carcinoma Progression Through Nuclear AMPK-SKP2-CARM1 Signaling Transcriptionally Regulating Nutrient-Deprived Autophagy Induction.
Wei X, Li X, Yan W, Zhang X, Sun Y, Zhang F
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;47(6):2484-2497
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;47(6):2484-2497
LOXL1 regulates cell apoptosis and migration in human neuroglioma U87 and U251 cells via Wnt/β-catenin signaling.
Li H, He X, Peng Y, Shao B, Duan H, Yang F, Chen H, Lan Q
International journal of clinical and experimental pathology 2018;11(4):2032-2037
International journal of clinical and experimental pathology 2018;11(4):2032-2037
Calycosin alleviates allergic contact dermatitis by repairing epithelial tight junctions via down-regulating HIF-1α.
Jia Z, Wang X, Wang X, Wei P, Li L, Wu P, Hong M
Journal of cellular and molecular medicine 2018 Sep;22(9):4507-4521
Journal of cellular and molecular medicine 2018 Sep;22(9):4507-4521
Role of c-Abl-GSK3β Signaling in MPP+-Induced Autophagy-Lysosomal Dysfunction.
Ren Y, Chen J, Wu X, Gui C, Mao K, Zou F, Li W
Toxicological sciences : an official journal of the Society of Toxicology 2018 Sep 1;165(1):232-243
Toxicological sciences : an official journal of the Society of Toxicology 2018 Sep 1;165(1):232-243
Paracrine HGF/c-MET enhances the stem cell-like potential and glycolysis of pancreatic cancer cells via activation of YAP/HIF-1α.
Yan B, Jiang Z, Cheng L, Chen K, Zhou C, Sun L, Qian W, Li J, Cao J, Xu Q, Ma Q, Lei J
Experimental cell research 2018 Oct 1;371(1):63-71
Experimental cell research 2018 Oct 1;371(1):63-71
Functional interplay between liver X receptor and AMP-activated protein kinase α inhibits atherosclerosis in apolipoprotein E-deficient mice - a new anti-atherogenic strategy.
Ma C, Zhang W, Yang X, Liu Y, Liu L, Feng K, Zhang X, Yang S, Sun L, Yu M, Yang J, Li X, Hu W, Miao RQ, Zhu Y, Li L, Han J, Chen Y, Duan Y
British journal of pharmacology 2018 May;175(9):1486-1503
British journal of pharmacology 2018 May;175(9):1486-1503
SET1A-Mediated Mono-Methylation at K342 Regulates YAP Activation by Blocking Its Nuclear Export and Promotes Tumorigenesis.
Fang L, Teng H, Wang Y, Liao G, Weng L, Li Y, Wang X, Jin J, Jiao C, Chen L, Peng X, Chen J, Yang Y, Fang H, Han D, Li C, Jin X, Zhang S, Liu Z, Liu M, Wei Q, Liao L, Ge X, Zhao B, Zhou D, Qin HL, Zhou J, Wang P
Cancer cell 2018 Jul 9;34(1):103-118.e9
Cancer cell 2018 Jul 9;34(1):103-118.e9
Activation of hepatic Nogo-B receptor expression-A new anti-liver steatosis mechanism of statins.
Zhang W, Yang X, Chen Y, Hu W, Liu L, Zhang X, Liu M, Sun L, Liu Y, Yu M, Li X, Li L, Zhu Y, Miao QR, Han J, Duan Y
Biochimica et biophysica acta. Molecular and cell biology of lipids 2018 Feb;1863(2):177-190
Biochimica et biophysica acta. Molecular and cell biology of lipids 2018 Feb;1863(2):177-190
Ubiquitination Regulates the Proteasomal Degradation and Nuclear Translocation of the Fat Mass and Obesity-Associated (FTO) Protein.
Zhu T, Yong XLH, Xia D, Widagdo J, Anggono V
Journal of molecular biology 2018 Feb 2;430(3):363-371
Journal of molecular biology 2018 Feb 2;430(3):363-371
Baicalein protects human vitiligo melanocytes from oxidative stress through activation of NF-E2-related factor2 (Nrf2) signaling pathway.
Ma J, Li S, Zhu L, Guo S, Yi X, Cui T, He Y, Chang Y, Liu B, Li C, Jian Z
Free radical biology & medicine 2018 Dec;129:492-503
Free radical biology & medicine 2018 Dec;129:492-503
Hypoxia-Induced Mitogenic Factor Promotes Cardiac Hypertrophy via Calcium-Dependent and Hypoxia-Inducible Factor-1α Mechanisms.
Kumar S, Wang G, Liu W, Ding W, Dong M, Zheng N, Ye H, Liu J
Hypertension (Dallas, Tex. : 1979) 2018 Aug;72(2):331-342
Hypertension (Dallas, Tex. : 1979) 2018 Aug;72(2):331-342
DExD/H-Box Helicase 36 Signaling via Myeloid Differentiation Primary Response Gene 88 Contributes to NF-κB Activation to Type 2 Porcine Reproductive and Respiratory Syndrome Virus Infection.
Jing H, Zhou Y, Fang L, Ding Z, Wang D, Ke W, Chen H, Xiao S
Frontiers in immunology 2017;8:1365
Frontiers in immunology 2017;8:1365
PADI2-Mediated Citrullination Promotes Prostate Cancer Progression.
Wang L, Song G, Zhang X, Feng T, Pan J, Chen W, Yang M, Bai X, Pang Y, Yu J, Han J, Han B
Cancer research 2017 Nov 1;77(21):5755-5768
Cancer research 2017 Nov 1;77(21):5755-5768
Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20.
Liu G, Zhou L, Zhang H, Chen R, Zhang Y, Li L, Lu JY, Jiang H, Liu D, Qi S, Jiang YM, Yin K, Xie Z, Shi Y, Liu Y, Cao X, Chen YX, Zou D, Zhang WJ
Nature communications 2017 Mar 22;8:14824
Nature communications 2017 Mar 22;8:14824
ERK1/2-mediated Cytoplasmic Accumulation of hnRNPK Antagonizes TRAIL-induced Apoptosis through Upregulation of XIAP in H1299 Cells.
Huang WS, Xu FM, Zeng QZ, Liu XH, Gao XJ, Liu LX
Biomedical and environmental sciences : BES 2017 Jul;30(7):473-481
Biomedical and environmental sciences : BES 2017 Jul;30(7):473-481
Highly expressed lncRNA CCND2-AS1 promotes glioma cell proliferation through Wnt/β-catenin signaling.
Zhang H, Wei DL, Wan L, Yan SF, Sun YH
Biochemical and biophysical research communications 2017 Jan 22;482(4):1219-1225
Biochemical and biophysical research communications 2017 Jan 22;482(4):1219-1225
CRB3 regulates contact inhibition by activating the Hippo pathway in mammary epithelial cells.
Mao X, Li P, Wang Y, Liang Z, Liu J, Li J, Jiang Y, Bao G, Li L, Zhu B, Ren Y, Zhao X, Zhang J, Liu Y, Yang J, Liu P
Cell death & disease 2017 Jan 12;8(1):e2546
Cell death & disease 2017 Jan 12;8(1):e2546
TRAIL facilitates cytokine expression and macrophage migration during hypoxia/reoxygenation via ER stress-dependent NF-κB pathway.
Jiang Y, Chen X, Fan M, Li H, Zhu W, Chen X, Cao C, Xu R, Wang Y, Ma Y
Molecular immunology 2017 Feb;82:123-136
Molecular immunology 2017 Feb;82:123-136
TRIM52: A nuclear TRIM protein that positively regulates the nuclear factor-kappa B signaling pathway.
Fan W, Liu T, Li X, Zhou Y, Wu M, Cui X, Chen H, Qian P
Molecular immunology 2017 Feb;82:114-122
Molecular immunology 2017 Feb;82:114-122
Cluster of Differentiation 36 Deficiency Aggravates Macrophage Infiltration and Hepatic Inflammation by Upregulating Monocyte Chemotactic Protein-1 Expression of Hepatocytes Through Histone Deacetylase 2-Dependent Pathway.
Zhong S, Zhao L, Wang Y, Zhang C, Liu J, Wang P, Zhou W, Yang P, Varghese Z, Moorhead JF, Chen Y, Ruan XZ
Antioxidants & redox signaling 2017 Aug 1;27(4):201-214
Antioxidants & redox signaling 2017 Aug 1;27(4):201-214
Nuclear retention of the lncRNA SNHG1 by doxorubicin attenuates hnRNPC-p53 protein interactions.
Shen Y, Liu S, Fan J, Jin Y, Tian B, Zheng X, Fu H
EMBO reports 2017 Apr;18(4):536-548
EMBO reports 2017 Apr;18(4):536-548
CRB3 downregulation confers breast cancer stem cell traits through TAZ/β-catenin.
Li P, Wang Y, Mao X, Jiang Y, Liu J, Li J, Wang J, Wang R, She J, Zhang J, Yang J, Liu Y, Liu P
Oncogenesis 2017 Apr 24;6(4):e322
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 10298-1-AP(lamin-A antibody) at dilution of 1:800
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using LMNA antibody 10298-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-lamin-A (IP:10298-1-AP, 3ug; Detection:10298-1-AP 1:1000) with A375 cells lysate 800ug.
- Sample type
- cell line
