PB9280
antibody from Boster Biological Technology
Targeting: LMNA
CMD1A, HGPS, LGMD1B, LMN1, LMNL1, MADA, PRO1
Antibody data
- Antibody Data
- Antigen structure
- References [4]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- PB9280 - Provider product page
- Provider
- Boster Biological Technology
- Product name
- Anti-Lamin A+C/LMNA Antibody Picoband™
- Antibody type
- Polyclonal
- Description
- Polyclonal antibody for LAMIN A/LMNA detection. Host: Rabbit.Size: 100μg/vial. Tested applications: WB, IHC-P, ICC/IF, FCM. Reactive species: Human;Mouse;Rat. LAMIN A/LMNA information: Molecular Weight: 74139 MW; Subcellular Localization: Nucleus. Nucleus envelope. Nucleus lamina. Nucleus, nucleoplasm. Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleaveage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin- A/C, which can then be inserted into the nuclear lamina. EMD is required for proper localization of non-farnesylated prelamin-A/C; Tissue Specificity: In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Vial size
- 100μg/vial
- Concentration
- Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
- Storage
- At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquoted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
- Handling
- Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Submitted references Polysaccharides from Polygonatum kingianum Collett & Hemsl ameliorated fatigue by regulating NRF2/HO-1/NQO1 and AMPK/PGC-1α/TFAM signaling pathways, and gut microbiota.
Innate immune receptors co-recognition of polysaccharides initiates multi-pathway synergistic immune response.
Exopolysaccharides from Lactobacillus plantarum NCU116 induce c-Jun dependent Fas/Fasl-mediated apoptosis via TLR2 in mouse intestinal epithelial cancer cells.
Loss of lamin A but not lamin C expression in epithelial ovarian cancer cells is associated with metastasis and poor prognosis.
Xu X, Shan M, Chu C, Bie S, Wang H, Cai S
International journal of biological macromolecules 2024 May;266(Pt 2):131440
International journal of biological macromolecules 2024 May;266(Pt 2):131440
Innate immune receptors co-recognition of polysaccharides initiates multi-pathway synergistic immune response.
Li M, Huang X, Wen J, Chen S, Wu X, Ma W, Cui SW, Xie M, Nie S
Carbohydrate polymers 2023 Apr 1;305:120533
Carbohydrate polymers 2023 Apr 1;305:120533
Exopolysaccharides from Lactobacillus plantarum NCU116 induce c-Jun dependent Fas/Fasl-mediated apoptosis via TLR2 in mouse intestinal epithelial cancer cells.
Zhou X, Hong T, Yu Q, Nie S, Gong D, Xiong T, Xie M
Scientific reports 2017 Oct 27;7(1):14247
Scientific reports 2017 Oct 27;7(1):14247
Loss of lamin A but not lamin C expression in epithelial ovarian cancer cells is associated with metastasis and poor prognosis.
Gong G, Chen P, Li L, Tan H, Zhou J, Zhou Y, Yang X, Wu X
Pathology, research and practice 2015 Feb;211(2):175-82
Pathology, research and practice 2015 Feb;211(2):175-82
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Supportive validation
- Submitted by
- Boster Biological Technology (provider)
- Main image
- Experimental details
- Anti- Lamin A Picoband antibody, PB9280, Western blottingAll lanes: Anti Lamin A (PB9280) at 0.5ug/mlLane 1: Human Placenta Tissue Lysate at 50ugLane 2: SKOV Whole Cell Lysate at 40ugLane 3: SW620 Whole Cell Lysate at 40ugLane 4: COLO320 Whole Cell Lysate at 40ugLane 5: HELA Whole Cell Lysate at 40ugLane 6: 293T Whole Cell Lysate at 40ugLane 7: A549 Whole Cell Lysate at 40ugPredicted bind size: 74KDObserved bind size: 74KD
- Additional image