PB9280

antibody from Boster Biological Technology
Targeting: LMNA CMD1A, HGPS, LGMD1B, LMN1, LMNL1, MADA, PRO1
Provider product page for PB9280
Western blot
Immunocytochemistry
Immunohistochemistry
Flow cytometry

Antibody data

Product number
PB9280 - Provider product page
Provider
Boster Biological Technology
Product name
Anti-Lamin A+C/LMNA Antibody Picoband™
Antibody type
Polyclonal
Description
Polyclonal antibody for LAMIN A/LMNA detection. Host: Rabbit.Size: 100μg/vial. Tested applications: WB, IHC-P, ICC/IF, FCM. Reactive species: Human;Mouse;Rat. LAMIN A/LMNA information: Molecular Weight: 74139 MW; Subcellular Localization: Nucleus. Nucleus envelope. Nucleus lamina. Nucleus, nucleoplasm. Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleaveage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin- A/C, which can then be inserted into the nuclear lamina. EMD is required for proper localization of non-farnesylated prelamin-A/C; Tissue Specificity: In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Vial size
100μg/vial
Concentration
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Storage
At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquoted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
Handling
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
LMNA protein structure - PB9280 shown in red.