16511-1-AP

antibody from Proteintech Group

Targeting: SUPT5H FLJ34157, SPT5, SPT5H

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Antibody Data

Product number

16511-1-AP

Provider

Proteintech Group

Product name

SUPT5H antibody

Antibody type

Polyclonal

Description

SUPT5H antibody (Cat. #16511-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IP, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Multiple structures of RNA polymerase II isolated from human nuclei by ChIP-CryoEM analysis.

Kujirai T, Kato J, Yamamoto K, Hirai S, Fujii T, Maehara K, Harada A, Negishi L, Ogasawara M, Yamaguchi Y, Ohkawa Y, Takizawa Y, Kurumizaka H
Nature communications 2025 May 28;16(1):4724

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FUBP3 enhances HIV-1 transcriptional activity and regulates immune response pathways in T cells.

Gibaut QMR, Li C, Cheng A, Moranguinho I, Mori LP, Valente ST
Molecular therapy. Nucleic acids 2025 Jun 10;36(2):102525

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DSS1 is required for proper Integrator-PP2A function.

Xu C, Zhou QX, Zheng H, Song A, Zhao WY, Xu TT, Xiong Y, Zhang YJ, Huang Z, Xu Y, Cheng J, Chen FX
Nature communications 2025 Jul 5;16(1):6206

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Three-step mechanism of promoter escape by RNA polymerase II.

Zhan Y, Grabbe F, Oberbeckmann E, Dienemann C, Cramer P
Molecular cell 2024 May 2;84(9):1699-1710.e6

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CDK7 kinase activity promotes RNA polymerase II promoter escape by facilitating initiation factor release.

Velychko T, Mohammad E, Ferrer-Vicens I, Parfentev I, Werner M, Studniarek C, Schwalb B, Urlaub H, Murphy S, Cramer P, Lidschreiber M
Molecular cell 2024 Jun 20;84(12):2287-2303.e10

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The PNUTS phosphatase complex controls transcription pause release.

Kelley JR, Dimitrova E, Maciuszek M, Nguyen HT, Szczurek AT, Hughes AL, Blackledge NP, Kettenbach AN, Klose RJ
Molecular cell 2024 Dec 19;84(24):4843-4861.e8

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The phosphatase PP1 sustains global transcription by promoting RNA polymerase II pause release.

Wang Z, Song A, Tao B, Miao M, Luo YQ, Wang J, Yin Z, Xiao R, Zhou X, Shang XY, Hu S, Liang K, Danko CG, Chen FX
Molecular cell 2024 Dec 19;84(24):4824-4842.e7

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Redundant pathways for removal of defective RNA polymerase II complexes at a promoter-proximal pause checkpoint.

Blears D, Lou J, Fong N, Mitter R, Sheridan RM, He D, Dirac-Svejstrup AB, Bentley D, Svejstrup JQ
Molecular cell 2024 Dec 19;84(24):4790-4807.e11

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INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase II.

Hu S, Peng L, Song A, Ji YX, Cheng J, Wang M, Chen FX
Molecular cell 2023 May 18;83(10):1588-1604.e5

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SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape.

Hu S, Peng L, Xu C, Wang Z, Song A, Chen FX
Molecular cell 2021 Nov 4;81(21):4425-4439.e6