10245-1-AP

antibody from Proteintech Group

Targeting: S100A6 2A9, CABP, CACY, PRA

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

10245-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#10245-1-AP, RRID:AB_2183801

Product name

S100A6 antibody

Antibody type

Polyclonal

Description

KD/KO validated S100A6 antibody (Cat. #10245-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Characterization of macrophages in ischemia-reperfusion injury-induced acute kidney injury based on single-cell RNA-Seq and bulk RNA-Seq analysis.

Wang Q, Liu Y, Zhang Y, Zhang S, Zhao M, Peng Z, Xu H, Huang H
International immunopharmacology 2024 Mar 30;130:111754

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Lineage tracing reveals transient phenotypic adaptation of tubular cells during acute kidney injury.

Buse M, Cheng M, Jankowski V, Lellig M, Sterzer V, Strieder T, Leuchtle K, Martin IV, Seikrit C, Brinkkoettter P, Crispatzu G, Floege J, Boor P, Speer T, Kramann R, Ostendorf T, Moeller MJ, Costa IG, Stamellou E
iScience 2024 Mar 15;27(3):109255

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S100A6 drives lymphatic metastasis of liver cancer via activation of the RAGE/NF-kB/VEGF-D pathway.

Chen T, Ruan Y, Ji L, Cai J, Tong M, Xue Y, Zhao H, Cai X, Xu J
Cancer letters 2024 Apr 10;587:216709

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WT1(+) glomerular parietal epithelial progenitors promote renal proximal tubule regeneration after severe acute kidney injury.

Hong X, Nie H, Deng J, Liang S, Chen L, Li J, Gong S, Wang G, Zuo W, Hou F, Zhang F
Theranostics 2023;13(4):1311-1324

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ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes.

Nixon-Abell J, Ruggeri FS, Qamar S, Herling TW, Czekalska MA, Shen Y, Wang G, King C, Fernandopulle MS, Sneideris T, Watson JL, Pillai VVS, Meadows W, Henderson JW, Chambers JE, Wagstaff JL, Williams SH, Coyle H, Lu Y, Zhang S, Marciniak SJ, Freund SMV, Derivery E, Ward ME, Vendruscolo M, Knowles TPJ, St George-Hyslop P
bioRxiv : the preprint server for biology 2023 Mar 24;

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S100A6 promotes the development of thyroid cancer and inhibits apoptosis of thyroid cancer cells through the PI3K/AKT/mTOR pathway.

Chen B, Zheng D, Liu C, Bhandari A, Hirachan S, Shen C, Mainali S, Li H, Jiang W, Xu J, Zhang X, Tang K, Zhang W
Pathology, research and practice 2023 Feb;242:154325

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Candidate therapeutic agents in a newly established triple wild-type mucosal melanoma cell line.

Shi C, Gu Z, Xu S, Ju H, Wu Y, Han Y, Li J, Li C, Wu J, Wang L, Li J, Zhou G, Ye W, Ren G, Zhang Z, Zhou R
Cancer communications (London, England) 2022 Jul;42(7):627-647

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Cellular architecture of human brain metastases.

Gonzalez H, Mei W, Robles I, Hagerling C, Allen BM, Hauge Okholm TL, Nanjaraj A, Verbeek T, Kalavacherla S, van Gogh M, Georgiou S, Daras M, Phillips JJ, Spitzer MH, Roose JP, Werb Z
Cell 2022 Feb 17;185(4):729-745.e20

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c-Myc Upregulated by High Glucose Inhibits HaCaT Differentiation by S100A6 Transcriptional Activation.

Zhang J, Yang P, Liu D, Gao M, Wang J, Wang X, Liu Y, Zhang X
Frontiers in endocrinology 2021;12:676403

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Genetic screening of ANXA11 revealed novel mutations linked to amyotrophic lateral sclerosis.

Teyssou E, Muratet F, Amador MD, Ferrien M, Lautrette G, Machat S, Boillée S, Larmonier T, Saker S, Leguern E, Cazeneuve C, Marie Y, Guegan J, Gyorgy B, Cintas P, Meininger V, Le Forestier N, Salachas F, Couratier P, Camu W, Seilhean D, Millecamps S
Neurobiology of aging 2021 Mar;99:102.e11-102.e20

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Single-cell reconstruction of the adult human heart during heart failure and recovery reveals the cellular landscape underlying cardiac function.

Wang L, Yu P, Zhou B, Song J, Li Z, Zhang M, Guo G, Wang Y, Chen X, Han L, Hu S
Nature cell biology 2020 Jan;22(1):108-119

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ZEB1 and IL-6/11-STAT3 signalling cooperate to define invasive potential of pancreatic cancer cells via differential regulation of the expression of S100 proteins.

Al-Ismaeel Q, Neal CP, Al-Mahmoodi H, Almutairi Z, Al-Shamarti I, Straatman K, Jaunbocus N, Irvine A, Issa E, Moreman C, Dennison AR, Emre Sayan A, McDearmid J, Greaves P, Tulchinsky E, Kriajevska M
British journal of cancer 2019 Jul;121(1):65-75

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Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis.

Smith BN, Topp SD, Fallini C, Shibata H, Chen HJ, Troakes C, King A, Ticozzi N, Kenna KP, Soragia-Gkazi A, Miller JW, Sato A, Dias DM, Jeon M, Vance C, Wong CH, de Majo M, Kattuah W, Mitchell JC, Scotter EL, Parkin NW, Sapp PC, Nolan M, Nestor PJ, Simpson M, Weale M, Lek M, Baas F, Vianney de Jong JM, Ten Asbroek ALMA, Redondo AG, Esteban-Pérez J, Tiloca C, Verde F, Duga S, Leigh N, Pall H, Morrison KE, Al-Chalabi A, Shaw PJ, Kirby J, Turner MR, Talbot K, Hardiman O, Glass JD, De Belleroche J, Maki M, Moss SE, Miller C, Gellera C, Ratti A, Al-Sarraj S, Brown RH Jr, Silani V, Landers JE, Shaw CE
Science translational medicine 2017 May 3;9(388)

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S100A6 promotes cell proliferation in human nasopharyngeal carcinoma via the p38/MAPK signaling pathway.

Li A, Shi D, Xu B, Wang J, Tang YL, Xiao W, Shen G, Deng W, Zhao C
Molecular carcinogenesis 2017 Mar;56(3):972-984

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S100A6 as a potential serum prognostic biomarker and therapeutic target in gastric cancer.

Zhang J, Zhang K, Jiang X, Zhang J
Digestive diseases and sciences 2014 Sep;59(9):2136-44

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Protein profiling the differences between diabetic and normal mouse cumulus cells.

Jiang GJ, Ma JY, Zhang GL, Mo FF, Zhang DW, Gao SH, Li XL
Molecular reproduction and development 2014 Dec;81(12):1080-5

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Ca(2+) /S100 proteins regulate HCV virus NS5A-FKBP8/FKBP38 interaction and HCV virus RNA replication.

Tani J, Shimamoto S, Mori K, Kato N, Moriishi K, Matsuura Y, Tokumitsu H, Tsuchiya M, Fujimoto T, Kato K, Miyoshi H, Masaki T, Kobayashi R
Liver international : official journal of the International Association for the Study of the Liver 2013 Aug;33(7):1008-18

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S100 proteins regulate the interaction of Hsp90 with Cyclophilin 40 and FKBP52 through their tetratricopeptide repeats.

Shimamoto S, Kubota Y, Tokumitsu H, Kobayashi R
FEBS letters 2010 Mar 19;584(6):1119-25

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Proteomic analysis of lung tissue of rats exposed to cigarette smoke and radon.

Xu NY, Zhang SP, Dong L, Nie JH, Tong J
Journal of toxicology and environmental health. Part A 2009;72(11-12):752-8

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Radon-induced proteomic profile of lung tissue in rats.

Xu NY, Zhang SP, Nie JH, Li JX, Tong J
Journal of toxicology and environmental health. Part A 2008;71(6):361-6

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

HeLa cells were subjected to SDS PAGE followed by western blot with 10245-1-AP(S100A6 antibody) at dilution of 1:800

Sample type

cell line

Immunocytochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunofluorescent analysis of MCF-7 cells, using S100A6 antibody 10245-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human lung cancer using 10245-1-AP(S100A6 antibody) at dilution of 1:50 (under 10x lens)

Sample type

tissue