13585-1-AP

antibody from Proteintech Group

Targeting: PRDX6 1-Cys, aiPLA2, AOP2, KIAA0106, MGC46173, NSGPx, p29, PRX

Provider product page for 13585-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [56]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [2]

Submit

Product number: 13585-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#13585-1-AP, RRID:AB_2168637
Product name: PRDX6 antibody
Antibody type: Polyclonal
Description: KD/KO validated PRDX6 antibody (Cat. #13585-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PRDX6 protein structure - 13585-1-AP shown in red.

Submitted references Integrated RNA-seq and scRNA-seq to explore the biological mechanisms of mitophagy-related genes in ulcerative colitis.

Ma J, Xu R, Liu Y, Shao J, Xu J, Qi Y
PloS one 2026;21(4):e0346974

Ferroptosis as a novel alternative cell death model in Hashimoto´s thyroiditis.

Sacristán-Gómez P, Delgado-Martín S, Serrano-Somavilla A, Sánchez de la Blanca N, Sampedro-Nuñez M, Sebastian-Valles F, Martínez-Ruiz A, Marazuela M, Martínez-Hernández R
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2026 May;198:119276

The natural flavonoid dihydromyricetin targets senescent cells via PRDX2 and alleviates age-related diseases.

Xu Q, Li G, Zhang H, Jiang Z, Gao X, Li Z, Langhi Prata LGP, Kirkland JL, Zhang G, Sun Y
Nature communications 2026 Mar 6;17(1)

Protocol for dissecting the aggregation-prone protein interactome with optogenetic-induced aggregation and biotin labeling proximity assay.

Teixeira M, Musiol D, Lambert JP, Oueslati A
STAR protocols 2026 Mar 20;7(1):104303

Li L, Pang J, Chen J, Pan Y, Liang L, Bai X, He Y, Yang H
Medicine 2026 Jan 23;105(4):e47262

Sirtuin 5-mediated desuccinylation of PRDX6 inhibits ferroptosis and alleviates sepsis-associated acute kidney injury.

Lin W, Dong C, Jiang Q, Lou Y, Wang L, He Z
Redox report : communications in free radical research 2026 Dec 31;31(1):2657075

SESN2 suppresses ferroptosis in polycystic ovary syndrome by maintaining PRDX6 K209 lactylation.

Li YY, Xu N, Gu XY, Yu B, Luan YY, Yin CH
Free radical biology & medicine 2026 Apr 9;251:75-90

Clinical value and molecular role of PRDXs family in prostate cancer.

Yao Y, Zheng Q, Qian C, Gu P, Zhang M, Zhang Z
Frontiers in oncology 2025;15:1713670

Air pollution decreases postsynaptic PSD-95 and NMDA receptor subunits in synaptosomes from mouse cerebral cortex.

Godoy-Lugo JA, Hicks D, Durra S, Massey ER, Shkirkova K, Sauri AI, Kerstiens E, Chen S, Zhao L, Sioutas C, Mack WJ, Finch CE, Thorwald MA
Environmental pollution (Barking, Essex : 1987) 2025 Oct 15;383:126845

RRM2-mediated inhibition of GPX4 ubiquitination: A novel mechanism for ferroptosis suppression and reduced cisplatin sensitivity in small cell lung cancer.

You L, Su Z, Xie J, He Y, Zhi S, Zheng S, Wang M, Li D, Liu Z
Cellular signalling 2025 Nov;135:112034

The ER thioredoxin-related transmembrane protein TMX2 controls redox-mediated tethering of ER-mitochondria contacts.

Chen J, Yap MC, Bassot A, Pascual DM, Makio T, Zimmermann J, Mast H, Bhat R, Fleury SG, Fan Y, Buzatto AZ, Moore J, Ballanyi K, Li L, Overduin M, Lemieux MJ, Lemieux H, Mancini GMS, Morgan B, Marcogliese PC, Simmen T
Cell reports 2025 Nov 25;44(11):116486

Malformin C preferentially kills glioblastoma stem-like cells via concerted induction of proteotoxic stress and autophagic flux blockade.

Phillips E, van Enk S, Kildgaard S, Schlue S, Göttmann M, Jennings V, Bethke F, Müller G, Herold-Mende C, Pastor-Flores D, Schneider M, Helm D, Ostenfeld Larsen T, Goidts V
Molecular oncology 2025 Mar;19(3):785-807

Targeting the PTN/PTPRZ1-ROS Pathway to Promote Bone Regeneration.

Zhao K, Guo Y, He Y, Wu Y, Hu Z, Chi X, Deng X
Biomedicines 2025 Mar 12;13(3)

MOTS-c attenuates lung ischemia-reperfusion injury via MYH9-Dependent nuclear translocation and transcriptional activation of antioxidant genes.

Li X, Zhan F, Qiu G, Lu P, Shen Z, Qi Y, Wu M, Chu M, Feng J, Wen Z, Yao X, Wang A, Jin W, Zhang X, Liao J, Zhang J, Song M, Wang W, Wang X
Redox biology 2025 Jul;84:103681

Combining light-induced aggregation and biotin proximity labeling implicates endolysosomal proteins in early α-synuclein oligomerization.

Teixeira M, Sheta R, Musiol D, Ranjakasoa V, Loehr J, Lambert JP, Oueslati A
iScience 2025 Jul 18;28(7):112823

Peroxiredoxin 6 maintains mitochondrial homeostasis and promotes tumor progression through ROS/JNK/p38 MAPK signaling pathway in multiple myeloma.

Gao D, Lv Y, Hong F, Wu D, Wang T, Gao G, Lin Z, Yang R, Hu J, He A, Zhang P
Scientific reports 2025 Jan 2;15(1):70

Inhibited peroxidase activity of peroxiredoxin 1 by palmitic acid exacerbates nonalcoholic steatohepatitis in male mice.

Yin W, Xu H, Bai Z, Wu Y, Zhang Y, Liu R, Wang Z, Zhang B, Shen J, Zhang H, Chen X, Ma D, Shi X, Yan L, Zhang C, Jiang H, Chen K, Guo D, Niu W, Yin H, Zhang WJ, Luo C, Xie X
Nature communications 2025 Jan 11;16(1):598

Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma.

Bischoff ME, Shamsaei B, Yang J, Secic D, Vemuri B, Reisz JA, D'Alessandro A, Bartolacci C, Adamczak R, Schmidt L, Wang J, Martines A, Venkat J, Tcheuyap VT, Biesiada J, Behrmann CA, Vest KE, Brugarolas J, Scaglioni PP, Plas DR, Patra KC, Gulati S, Landero Figueroa JA, Meller J, Cunningham JT, Czyzyk-Krzeska MF
Cancer discovery 2025 Feb 7;15(2):401-426

5-Methoxytryptophan attenuates hypobaric hypoxia induced acute lung injury by alleviating lipid peroxidation via targeting peroxiredoxin 6.

Lai X, Wan X, Bao X, Yang Q, Zhang W, Tan Y, Cai X, Wang Z, Li Y, Liu C, Deng Z, Zheng P, Tian D, Chen M, Yin H, Xu G, Huang Q, Zhang Z, Xia H, Deng F
Redox biology 2025 Dec;88:103922

Deficiency of PLA2G6 Induces Ferroptosis in Dopaminergic Neurons and Contributes to Parkinson's Disease Pathogenesis via Disruption of PRDX6/FTH1/GPX4 Axis.

Li T, Liu J, Huang X, Xie Y, Hu Y, Xu Q, Tang B, Tan J, Guo J
Molecular neurobiology 2025 Dec;62(12):15916-15927

Exploring Functionally Enhanced BLP-Trained Macrophage Subpopulations in S. Aureus Infection: Underlying Mechanisms and Therapeutic Significance.

Wan Y, Hong Y, Ji X, Xiang J, Liu J, Liang L, Ren M, Chen W, Xu T, Li Z, Shi T, Jiang Y, Liang H, Liu J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(47):e17142

Semenogelin I-derived peptide SgI-52 binds membrane Peroxiredoxin 6 and induces oxidative stress in asthenozoospermic sperm.

Yang Y, Lu C, Wu Z, Gao H, Li H, Deng R, Li X, He D, Zhao H
Reproductive biology and endocrinology : RB&E 2025 Dec 30;24(1):14

ALDH2 protects against dopaminergic neuronal cell ferroptosis by enhancing the enzyme activity of PRDX6 in Parkinson's disease.

Li X, Peng SJ, Wang Y, Chen X, Wu TT, Feng Y, Wang XX, Yin H, Wu YC
NPJ Parkinson's disease 2025 Dec 2;11(1):350

Snhg18 regulates Yap subcellular localization to maintain bone homeostasis.

Huang J, Weng Y, Feng Y, Wu D, Chen Y, Li Z, Jiang X, Wang H, Wang Z
Nature communications 2025 Aug 14;16(1):7543

Central role of Sigma-1 receptor in ochratoxin A-induced ferroptosis.

Chen W, Han L, Yang R, Wang H, Yao S, Deng H, Liu S, Zhou Y, Shen XL
Archives of toxicology 2024 Oct;98(10):3323-3336

Glycyrrhizin regulates antioxidation through Nrf2 signaling pathway in rat temporomandibular joint osteoarthritis.

Hu Z, Zhao J, Liu X, Li Y, Jiang H, Fang W, Long X
Journal of oral rehabilitation 2024 Mar;51(3):611-622

Loss of peroxiredoxin 6 alters lipid composition and distribution resulting in increased sensitivity to ferroptosis.

Lagal DJ, Ortiz-Alcántara Á, Pedrajas JR, McDonagh B, Bárcena JA, Requejo-Aguilar R, Padilla CA
The Biochemical journal 2024 Dec 23;481(24):1997-2015

PRDX6 augments selenium utilization to limit iron toxicity and ferroptosis.

Fujita H, Tanaka YK, Ogata S, Suzuki N, Kuno S, Barayeu U, Akaike T, Ogra Y, Iwai K
Nature structural & molecular biology 2024 Aug;31(8):1277-1285

Derivation and transcriptional reprogramming of border-forming wound repair astrocytes after spinal cord injury or stroke in mice.

O'Shea TM, Ao Y, Wang S, Ren Y, Cheng AL, Kawaguchi R, Shi Z, Swarup V, Sofroniew MV
Nature neuroscience 2024 Aug;27(8):1505-1521

PRDX6 alleviated heart failure by inhibiting doxorubicin-induced ferroptosis through the JAK2/STAT1 pathway inactivation.

Xiong J, Zhou R, Deng X
In vitro cellular & developmental biology. Animal 2024 Apr;60(4):354-364

Glycyrrhetinic acid inhibits non-small cell lung cancer via promotion of Prdx6- and caspase-3-mediated mitochondrial apoptosis.

Guo Q, Zhao M, Wang Q, Lu T, Luo P, Chen L, Xia F, Pang H, Shen S, Cheng G, Dai C, Meng Y, Zhong T, Qiu C, Wang J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Apr;173:116304

The PRX-1/TLR4 axis promotes hypoxia-induced radiotherapy resistance in non-small cell lung cancer by targeting the NF-κB/p65 pathway.

Hao J, Song Z, Su J, Li L, Zou L, Zou K
Cellular signalling 2023 Oct;110:110806

Peroxiredoxin-6 Released by Astrocytes Contributes to Neuroapoptosis During Ischemia.

Hou JY, Zhou XL, Wang XY, Liang J, Xue Q
Neuroscience 2023 Feb 21;512:59-69

Curcumin strengthens a spontaneous self-protective mechanism-SP1/PRDX6 pathway, against di-n-butyl phthalate-induced testicular ferroptosis damage.

Bu H, Wang B, Wu Y, Li P, Cui Y, Jiang X, Yu X, Liu B, Tang M
Environmental science and pollution research international 2023 Dec;30(58):122165-122181

Endoplasmic Reticulum Protein TXNDC5 Interacts with PRDX6 and HSPA9 to Regulate Glutathione Metabolism and Lipid Peroxidation in the Hepatic AML12 Cell Line.

Bidooki SH, Sánchez-Marco J, Martínez-Beamonte R, Herrero-Continente T, Navarro MA, Rodríguez-Yoldi MJ, Osada J
International journal of molecular sciences 2023 Dec 5;24(24)

Construction and validation of a novel ferroptosis-related prognostic signature for lung adenocarcinoma.

Yang L, Fan X, Zhou C, Wang Z, Cui Z, Wu X, Xu Z, Yang J, Zhang X
Translational lung cancer research 2023 Aug 30;12(8):1766-1781

Comparative Analysis of Proteomic of Curcumin Reversing Multidrug Resistance in HCT-8/VCR Cells.

Li L, Yu L, Cao X, Zhang C, Liu Q, Chen J
Journal of oncology 2022;2022:3605436

PRDX6 alleviates lipopolysaccharide-induced inflammation and ferroptosis in periodontitis.

Yang WY, Meng X, Wang YR, Wang QQ, He X, Sun XY, Cheng N, Zhang L
Acta odontologica Scandinavica 2022 Oct;80(7):535-546

NPM1 promotes cell proliferation by targeting PRDX6 in colorectal cancer.

Wang D, Li Y, Liu Y, Cheng S, Liu F, Zuo R, Ding C, Shi S, Liu G
The international journal of biochemistry & cell biology 2022 Jun;147:106233

Notch3 regulates ferroptosis via ROS-induced lipid peroxidation in NSCLC cells.

Li Z, Xiao J, Liu M, Cui J, Lian B, Sun Y, Li C
FEBS open bio 2022 Jun;12(6):1197-1205

Chronic angiotensin receptor activation promotes hepatic triacylglycerol accumulation during an acute glucose challenge in obese-insulin-resistant OLETF rats.

Godoy-Lugo JA, Thorwald MA, Hui DY, Nishiyama A, Nakano D, Soñanez-Organis JG, Ortiz RM
Endocrine 2022 Jan;75(1):92-107

Knocking Down Peroxiredoxin 6 Aggravates Cerebral Ischemia-Reperfusion Injury by Enhancing Mitophagy.

Hong T, Zhou Y, Peng L, Wu X, Li Y, Li Y, Zhao Y
Neuroscience 2022 Feb 1;482:30-42

Identification of a Novel Ferroptosis-Related Gene Prognostic Signature in Bladder Cancer.

Sun J, Yue W, You J, Wei X, Huang Y, Ling Z, Hou J
Frontiers in oncology 2021;11:730716

Hypothermic oxygenated perfusion with defatting cocktail further improves steatotic liver grafts in a transplantation rat model.

Lin F, Zhen F, Yan X, Shaojun Y, Guizhu P, Yanfeng W, Qifa Y
Artificial organs 2021 Sep;45(9):E304-E316

Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance.

Huang H, Zhang S, Li Y, Liu Z, Mi L, Cai Y, Wang X, Chen L, Ran H, Xiao D, Li F, Wu J, Li T, Han Q, Chen L, Pan X, Li H, Li T, He K, Li A, Zhang X, Zhou T, Xia Q, Man J
Nature communications 2021 Jun 17;12(1):3720

Peroxiredoxins are involved in the pathogenesis of multiple sclerosis and neuromyelitis optica spectrum disorder.

Uzawa A, Mori M, Masuda H, Ohtani R, Uchida T, Aoki R, Kuwabara S
Clinical and experimental immunology 2020 Nov;202(2):239-248

Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways.

Ma Z, Lu Y, Yang F, Li S, He X, Gao Y, Zhang G, Ren E, Wang Y, Kang X
Toxicology and applied pharmacology 2020 Jun 15;397:115014

Novel [1,2,3]triazolo[4,5-d]pyrimidine derivatives containing hydrazone fragment as potent and selective anticancer agents.

Xu C, Zhou W, Dong G, Qiao H, Peng J, Jia P, Li Y, Liu H, Sun K, Zhao W
Bioorganic chemistry 2020 Dec;105:104424

Identification of PRDX6 as a regulator of ferroptosis.

Lu B, Chen XB, Hong YC, Zhu H, He QJ, Yang B, Ying MD, Cao J
Acta pharmacologica Sinica 2019 Oct;40(10):1334-1342

The role of cytochrome P450 2E1 on ethanol-mediated oxidative stress and HIV replication in human monocyte-derived macrophages.

Gong Y, Rao PSS, Sinha N, Ranjit S, Cory TJ, Kumar S
Biochemistry and biophysics reports 2019 Mar;17:65-70

4-tert-octylphenol injures motility and viability of human sperm by affecting cAMP-PKA/PKC-tyrosine phosphorylation signals.

Huang S, Cao S, Zhou T, Kong L, Liang G
Environmental toxicology and pharmacology 2018 Sep;62:234-243

Luteolin ameliorates rat myocardial ischaemia-reperfusion injury through activation of peroxiredoxin II.

Wei B, Lin Q, Ji YG, Zhao YC, Ding LN, Zhou WJ, Zhang LH, Gao CY, Zhao W
British journal of pharmacology 2018 Aug;175(16):3315-3332

Nucleophosmin Regulates Intracellular Oxidative Stress Homeostasis via Antioxidant PRDX6.

Liu GY, Shi JX, Shi SL, Liu F, Rui G, Li X, Gao LB, Deng XL, Li QF
Journal of cellular biochemistry 2017 Dec;118(12):4697-4707

Peroxiredoxin 6 Is a Crucial Factor in the Initial Step of Mitochondrial Clearance and Is Upstream of the PINK1-Parkin Pathway.

Ma S, Zhang X, Zheng L, Li Z, Zhao X, Lai W, Shen H, Lv J, Yang G, Wang Q, Ji J
Antioxidants & redox signaling 2016 Mar 20;24(9):486-501

Functional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs.

Sahu N, Stephan JP, Cruz DD, Merchant M, Haley B, Bourgon R, Classon M, Settleman J
Nature communications 2016 Aug 3;7:12351

MNRR1 (formerly CHCHD2) is a bi-organellar regulator of mitochondrial metabolism.

Aras S, Bai M, Lee I, Springett R, Hüttemann M, Grossman LI
Mitochondrion 2015 Jan;20:43-51

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: A549 cells were subjected to SDS PAGE followed by western blot with 13585-1-AP(PRDX6 antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of Hela cells, using PRDX6 antibody 13585-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human brain using 13585-1-AP(PRDX6 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human brain using 13585-1-AP(PRDX6 antibody) at dilution of 1:50 (under 40x lens)
Sample type: tissue