Antibody data
- Antibody Data
- Antigen structure
- References [15]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 11355-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11355-1-AP, RRID:AB_2092319
- Product name
- LGP2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated LGP2 antibody (Cat. #11355-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Comparative proteomics analysis of kidney in chicken infected by infectious bronchitis virus.
HOIL1 mediates MDA5 activation through ubiquitination of LGP2.
Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis.
LGP2 Promotes Type I Interferon Production To Inhibit PRRSV Infection via Enhancing MDA5-Mediated Signaling.
PKR Binds Enterovirus IRESs, Displaces Host Translation Factors, and Impairs Viral Translation to Enable Innate Antiviral Signaling.
Immune regulator LGP2 targets Ubc13/UBE2N to mediate widespread interference with K63 polyubiquitination and NF-κB activation.
RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection.
DExH-Box helicase 58 enhances osteoblast differentiation of osteoblastic cells via Wnt/β-Catenin signaling.
Innate immune sensor laboratory of genetics and physiology 2 suppresses tumor cell growth and functions as a prognostic marker in neuroblastoma.
RNA sensor LGP2 inhibits TRAF ubiquitin ligase to negatively regulate innate immune signaling.
miR-122 does not impact recognition of the HCV genome by innate sensors of RNA but rather protects the 5' end from the cellular pyrophosphatases, DOM3Z and DUSP11.
The TAR-RNA binding protein is required for immunoresponses triggered by Cardiovirus infection.
Ambivalent role of the innate immune response in rabies virus pathogenesis.
The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA.
Characterization of retinoic acid-inducible gene-I expression in primary murine glia following exposure to vesicular stomatitis virus.
Huang M, Zheng X, Zhang Y, Wang R, Wei X
Poultry science 2024 Jan;103(1):103259
Poultry science 2024 Jan;103(1):103259
HOIL1 mediates MDA5 activation through ubiquitination of LGP2.
Cheng D, Zhu J, Liu G, Gack MU, MacDuff DA
bioRxiv : the preprint server for biology 2024 Apr 3;
bioRxiv : the preprint server for biology 2024 Apr 3;
Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis.
Jia KW, Yao RQ, Fan YW, Zhang DJ, Zhou Y, Wang MJ, Zhang LY, Dong Y, Li ZX, Wang SY, Wang M, Li YH, Zhang LX, Lei T, Gui LC, Lu S, Yang YY, Wang SX, Yu YZ, Yao YM, Hou J
Military Medical Research 2024 Apr 15;11(1):22
Military Medical Research 2024 Apr 15;11(1):22
LGP2 Promotes Type I Interferon Production To Inhibit PRRSV Infection via Enhancing MDA5-Mediated Signaling.
Zhu Z, Zhang M, Yuan L, Xu Y, Zhou H, Lian Z, Liu P, Li X
Journal of virology 2023 Jan 31;97(1):e0184322
Journal of virology 2023 Jan 31;97(1):e0184322
PKR Binds Enterovirus IRESs, Displaces Host Translation Factors, and Impairs Viral Translation to Enable Innate Antiviral Signaling.
Dobrikov MI, Dobrikova EY, McKay ZP, Kastan JP, Brown MC, Gromeier M
mBio 2022 Jun 28;13(3):e0085422
mBio 2022 Jun 28;13(3):e0085422
Immune regulator LGP2 targets Ubc13/UBE2N to mediate widespread interference with K63 polyubiquitination and NF-κB activation.
Lenoir JJ, Parisien JP, Horvath CM
Cell reports 2021 Dec 28;37(13):110175
Cell reports 2021 Dec 28;37(13):110175
RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection.
Stone AEL, Green R, Wilkins C, Hemann EA, Gale M Jr
Nature communications 2019 Aug 13;10(1):3649
Nature communications 2019 Aug 13;10(1):3649
DExH-Box helicase 58 enhances osteoblast differentiation of osteoblastic cells via Wnt/β-Catenin signaling.
Zhou L, Sun S, Xu L, Yu Y, Zhang T, Wang M
Biochemical and biophysical research communications 2019 Apr 2;511(2):307-311
Biochemical and biophysical research communications 2019 Apr 2;511(2):307-311
Innate immune sensor laboratory of genetics and physiology 2 suppresses tumor cell growth and functions as a prognostic marker in neuroblastoma.
Lin LL, Huang CC, Wu MT, Hsu WM, Chuang JH
Cancer science 2018 Nov;109(11):3494-3502
Cancer science 2018 Nov;109(11):3494-3502
RNA sensor LGP2 inhibits TRAF ubiquitin ligase to negatively regulate innate immune signaling.
Parisien JP, Lenoir JJ, Mandhana R, Rodriguez KR, Qian K, Bruns AM, Horvath CM
EMBO reports 2018 Jun;19(6)
EMBO reports 2018 Jun;19(6)
miR-122 does not impact recognition of the HCV genome by innate sensors of RNA but rather protects the 5' end from the cellular pyrophosphatases, DOM3Z and DUSP11.
Amador-Cañizares Y, Bernier A, Wilson JA, Sagan SM
Nucleic acids research 2018 Jun 1;46(10):5139-5158
Nucleic acids research 2018 Jun 1;46(10):5139-5158
The TAR-RNA binding protein is required for immunoresponses triggered by Cardiovirus infection.
Komuro A, Homma Y, Negoro T, Barber GN, Horvath CM
Biochemical and biophysical research communications 2016 Nov 11;480(2):187-193
Biochemical and biophysical research communications 2016 Nov 11;480(2):187-193
Ambivalent role of the innate immune response in rabies virus pathogenesis.
Chopy D, Pothlichet J, Lafage M, Mégret F, Fiette L, Si-Tahar M, Lafon M
Journal of virology 2011 Jul;85(13):6657-68
Journal of virology 2011 Jul;85(13):6657-68
The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA.
Li X, Ranjith-Kumar CT, Brooks MT, Dharmaiah S, Herr AB, Kao C, Li P
The Journal of biological chemistry 2009 May 15;284(20):13881-13891
The Journal of biological chemistry 2009 May 15;284(20):13881-13891
Characterization of retinoic acid-inducible gene-I expression in primary murine glia following exposure to vesicular stomatitis virus.
Furr SR, Chauhan VS, Sterka D Jr, Grdzelishvili V, Marriott I
Journal of neurovirology 2008 Nov;14(6):503-13
Journal of neurovirology 2008 Nov;14(6):503-13
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse liver tissue were subjected to SDS PAGE followed by western blot with 11355-1-AP(DHX58 antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-DHX58 (IP:11355-1-AP, 3ug; Detection:11355-1-AP 1:300) with mouse liver tissue lysate 6000ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The LGP2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human LGP2. This antibody recognizes human,mouse,rat antigen. The LGP2 antibody has been validated for the following applications: ELISA, IHC, IP, WB analysis.