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- Antigen structure
- References [15]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 14951-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14951-1-AP, RRID:AB_2128158
- Product name
- KARS antibody
- Antibody type
- Polyclonal
- Description
- KARS antibody (Cat. #14951-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references VILMIR is a trans-acting long noncoding RNA that enhances the host interferon response in human epithelial cells.
Variant-specific interaction of kinectin 1 with the multi-tRNA synthetase complex regulates ER sheet organization.
A methyltransferase-independent role for METTL1 in tRNA aminoacylation and oncogenic transformation.
VILMIR is a trans-acting long noncoding RNA that enhances the host interferon response in human epithelial cells.
Characterizing the differential distribution and targets of Sumo1 and Sumo2 in the mouse brain.
Multimodal cotranslational interactions direct assembly of the human multi-tRNA synthetase complex.
Leopard-like retinopathy and severe early-onset portal hypertension expand the phenotype of KARS1-related syndrome: a case report.
Regulation of ex-translational activities is the primary function of the multi-tRNA synthetase complex.
Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation.
Deletion of Gtpbp3 in zebrafish revealed the hypertrophic cardiomyopathy manifested by aberrant mitochondrial tRNA metabolism.
Deletion of Mtu1 (Trmu) in zebrafish revealed the essential role of tRNA modification in mitochondrial biogenesis and hearing function.
Novel RNA-Affinity Proteogenomics Dissects Tumor Heterogeneity for Revealing Personalized Markers in Precision Prognosis of Cancer.
Inhibition of mitochondrial translation in fibroblasts from a patient expressing the KARS p.(Pro228Leu) variant and presenting with sensorineural deafness, developmental delay, and lactic acidosis.
Ehrlichia chaffeensis Tandem Repeat Effector Targets Differentially Influence Infection.
Novel mutations in KARS cause hypertrophic cardiomyopathy and combined mitochondrial respiratory chain defect.
John K, Smith E, Istishin A, Mahmood N, Diveley K, Tollison TS, Carpenter S, Peng X
Journal of virology 2026 Jan 20;100(1):e0138025
Journal of virology 2026 Jan 20;100(1):e0138025
Variant-specific interaction of kinectin 1 with the multi-tRNA synthetase complex regulates ER sheet organization.
Hosogane M, Siao SY, Hatano A, Huang X, Shichino Y, Watanabe Y, Iwasaki S, Matsumoto M, Nakayama K
iScience 2026 Jan 16;29(1):114303
iScience 2026 Jan 16;29(1):114303
A methyltransferase-independent role for METTL1 in tRNA aminoacylation and oncogenic transformation.
Ali RH, Orellana EA, Lee SH, Chae YC, Chen Y, Clauwaert J, Kennedy AL, Gutierrez AE, Papke DJ, Valenzuela M, Silverman B, Falzetta A, Ficarro SB, Marto JA, Fletcher CDM, Perez-Atayde A, Alcindor T, Shimamura A, Prensner JR, Gregory RI, Gutierrez A
Molecular cell 2025 Mar 6;85(5):948-961.e11
Molecular cell 2025 Mar 6;85(5):948-961.e11
VILMIR is a trans-acting long noncoding RNA that enhances the host interferon response in human epithelial cells.
John K, Smith E, Istishin A, Mahmood N, Diveley K, Tollison TS, Carpenter S, Peng X
bioRxiv : the preprint server for biology 2025 Aug 22;
bioRxiv : the preprint server for biology 2025 Aug 22;
Characterizing the differential distribution and targets of Sumo1 and Sumo2 in the mouse brain.
Suk TR, Nguyen TT, Fisk ZA, Mitkovski M, Geertsma HM, Parmasad JA, Heer MM, Callaghan SM, Benseler F, Brose N, Tirard M, Rousseaux MWC
iScience 2023 Apr 21;26(4):106350
iScience 2023 Apr 21;26(4):106350
Multimodal cotranslational interactions direct assembly of the human multi-tRNA synthetase complex.
Khan K, Long B, Gogonea V, Deshpande GM, Vasu K, Fox PL
Proceedings of the National Academy of Sciences of the United States of America 2022 Sep 6;119(36):e2205669119
Proceedings of the National Academy of Sciences of the United States of America 2022 Sep 6;119(36):e2205669119
Leopard-like retinopathy and severe early-onset portal hypertension expand the phenotype of KARS1-related syndrome: a case report.
Peluso F, Palazzo V, Indolfi G, Mari F, Pasqualetti R, Procopio E, Nesti C, Guerrini R, Santorelli F, Giglio S
BMC medical genomics 2021 Jan 21;14(1):25
BMC medical genomics 2021 Jan 21;14(1):25
Regulation of ex-translational activities is the primary function of the multi-tRNA synthetase complex.
Cui H, Kapur M, Diedrich JK, Yates JR, Ackerman SL, Schimmel P
Nucleic acids research 2021 Apr 19;49(7):3603-3616
Nucleic acids research 2021 Apr 19;49(7):3603-3616
Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation.
Guerra J, Valadao AL, Vlachakis D, Polak K, Vila IK, Taffoni C, Prabakaran T, Marriott AS, Kaczmarek R, Houel A, Auzemery B, Déjardin S, Boudinot P, Nawrot B, Jones NJ, Paludan SR, Kossida S, Langevin C, Laguette N
Science advances 2020 May;6(21):eaax3333
Science advances 2020 May;6(21):eaax3333
Deletion of Gtpbp3 in zebrafish revealed the hypertrophic cardiomyopathy manifested by aberrant mitochondrial tRNA metabolism.
Chen D, Zhang Z, Chen C, Yao S, Yang Q, Li F, He X, Ai C, Wang M, Guan MX
Nucleic acids research 2019 Jun 4;47(10):5341-5355
Nucleic acids research 2019 Jun 4;47(10):5341-5355
Deletion of Mtu1 (Trmu) in zebrafish revealed the essential role of tRNA modification in mitochondrial biogenesis and hearing function.
Zhang Q, Zhang L, Chen D, He X, Yao S, Zhang Z, Chen Y, Guan MX
Nucleic acids research 2018 Nov 16;46(20):10930-10945
Nucleic acids research 2018 Nov 16;46(20):10930-10945
Novel RNA-Affinity Proteogenomics Dissects Tumor Heterogeneity for Revealing Personalized Markers in Precision Prognosis of Cancer.
Wang L, Wrobel JA, Xie L, Li D, Zurlo G, Shen H, Yang P, Wang Z, Peng Y, Gunawardena HP, Zhang Q, Chen X
Cell chemical biology 2018 May 17;25(5):619-633.e5
Cell chemical biology 2018 May 17;25(5):619-633.e5
Inhibition of mitochondrial translation in fibroblasts from a patient expressing the KARS p.(Pro228Leu) variant and presenting with sensorineural deafness, developmental delay, and lactic acidosis.
Ruzzenente B, Assouline Z, Barcia G, Rio M, Boddaert N, Munnich A, Rötig A, Metodiev MD
Human mutation 2018 Dec;39(12):2047-2059
Human mutation 2018 Dec;39(12):2047-2059
Ehrlichia chaffeensis Tandem Repeat Effector Targets Differentially Influence Infection.
Luo T, Dunphy PS, McBride JW
Frontiers in cellular and infection microbiology 2017;7:178
Frontiers in cellular and infection microbiology 2017;7:178
Novel mutations in KARS cause hypertrophic cardiomyopathy and combined mitochondrial respiratory chain defect.
Verrigni D, Diodato D, Di Nottia M, Torraco A, Bellacchio E, Rizza T, Tozzi G, Verardo M, Piemonte F, Tasca G, D'Amico A, Bertini E, Carrozzo R
Clinical genetics 2017 Jun;91(6):918-923
Clinical genetics 2017 Jun;91(6):918-923
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 14951-1-AP(KARS antibody) at dilution of 1:400
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human placenta using 14951-1-AP(KARS antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The KARS antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human KARS. This antibody recognizes human, mouse, rat antigen. The KARS antibody has been validated for the following applications: ELISA, WB, IHC analysis.
