BS4158

antibody from Bioworld Technology, Inc
Targeting: PGR NR3C3, PR
Provider product page for BS4158
Western blot
Immunohistochemistry

Antibody data

Product number
BS4158 - Provider product page
Provider
Bioworld Technology, Inc
Proper citation
Bioworld Technology Cat#BS4158, RRID:AB_1663275
Product name
PR (phospho S190) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic phosphopeptide derived from human PR around the phosphorylation site of Serine 190.
Description
The effects of progesterone are mediated by two functionally different isoforms of the progesterone receptor, PR-A and PR-B, which are transcribed from distinct, estrogen inducible promoters within a single copy of the PR gene. The PR-A and PR-B proteins are 90 kDa and 118 kDa respectively; the first 164 amino acids of PR-B are absent in PR-A. Progesterone bound PR-A and PR-B have different transcription activation properties. Specifically, PR-B functions as a transcriptional activator in most cell and promoter contexts, while PR-A is transcriptionally inactive and functions as a strong ligand dependent transdominant repressor of steroid hormone receptor transcriptiona activity. An inhibitory domain (ID), which maps to the amino terminus of the receptor, exists within both PR isoforms.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PGR protein structure - BS4158 shown in red.