DCABH-2762

antibody from Creative Diagnostics

Targeting: PGR NR3C3, PR

No application information provided.

Antibody Data

Product number

DCABH-2762

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DCABH-2762, RRID:AB_2476651

Product name

Rabbit Anti-Human PGR monoclonal antibody, clone KG1650

Antibody type

Monoclonal

Description

The effects of progesterone are mediated by two functionally different isoforms of the progesterone receptor, PR-A and PR-B, which are transcribed from distinct, estrogen-inducible promoters within a single copy of the PR gene. The first 164 amino acids of PR-B are absent in PR-A. Progesterone-bound PR-A and PR-B have different transcription activation properties. Specifically, PR-B functions as a transcriptional activator in most cell and promoter contexts, while PR-A is transcriptionally inactive and functions as a strong ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity. An inhibitory domain (ID), which maps to the amino terminus of the receptor, exists within both PR isoforms. Interestingly, the ID is functionally active only in PR-A and is necessary for steroid hormone transrepression by PR-A, suggesting that PR-A and PR-B may have different conformations in the cell. Phosphorylation of human PR occurs on at least nine serine residues. Phosphorylation of three of the residues is hormone-inducible (Ser 102, Ser 294 and Ser 345)