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Learn22460-1-AP
antibody from Proteintech Group
Targeting: NR5A2
B1F2, FTF, FTZ-F1, FTZ-F1beta, hB1F, hB1F-2, LRH-1, LRH1
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [11]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- 22460-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- NR5A2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated NR5A2 antibody (Cat. #22460-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references NR5A2 promotes epithelial-to-mesenchymal transition in renal fibrosis by targeting MMP25 transcription.
HSD3B1 upregulation via LRH1 sustains estrogen receptor signaling and promotes endocrine resistance in breast cancer.
Hepatic FXR-FGF4 is required for bile acid homeostasis via an FGFR4-LRH-1 signal node under cholestatic stress.
Dengue virus NS1 leads to downregulation of HNF4 alpha in liver cells resulting in a decrease in coagulation factors I, V, X, and XIII, contributing to coagulopathy.
LRH-1 activation alleviates diabetes-induced podocyte injury by promoting GLS2-mediated glutaminolysis.
NR5A2 as a potential target for exercise to improve metabolic syndrome.
miR-27a-3p targets NR5A2 to regulate CYP19A1 expression and 17-β estradiol synthesis in ovine granulosa cells.
NR5A2 Is One of 12 Transcription Factors Predicting Prognosis in HNSCC and Regulates Cancer Cell Proliferation in a p53-Dependent Manner.
NR5A2 transcriptional activation by BRD4 promotes pancreatic cancer progression by upregulating GDF15.
Geniposide reduces cholesterol accumulation and increases its excretion by regulating the FXR-mediated liver-gut crosstalk of bile acids.
MicroRNA-3613-5p Promotes Lung Adenocarcinoma Cell Proliferation through a RELA and AKT/MAPK Positive Feedback Loop.
Wang X, Chang Y, Qian Y, Shan WM, Chen G, Li XW, Zhou JH
Biochimica et biophysica acta. Molecular basis of disease 2026 Mar;1872(3):168121
Biochimica et biophysica acta. Molecular basis of disease 2026 Mar;1872(3):168121
HSD3B1 upregulation via LRH1 sustains estrogen receptor signaling and promotes endocrine resistance in breast cancer.
Li X, Chung YM, Patel M, Sharifi N
The Journal of biological chemistry 2025 Jul;301(7):110405
The Journal of biological chemistry 2025 Jul;301(7):110405
Hepatic FXR-FGF4 is required for bile acid homeostasis via an FGFR4-LRH-1 signal node under cholestatic stress.
Song L, Hou Y, Xu D, Dai X, Luo J, Liu Y, Huang Z, Yang M, Chen J, Hu Y, Chen C, Tang Y, Rao Z, Ma J, Zheng M, Shi K, Cai C, Lu M, Tang R, Ma X, Xie C, Luo Y, Li X, Huang Z
Cell metabolism 2025 Jan 7;37(1):104-120.e9
Cell metabolism 2025 Jan 7;37(1):104-120.e9
Dengue virus NS1 leads to downregulation of HNF4 alpha in liver cells resulting in a decrease in coagulation factors I, V, X, and XIII, contributing to coagulopathy.
Das S, Mallik MH, Chattopadyay P, Mallick S, Karmakar D, Ghora S, Begum F, Chatterjee B, Thagriki DS, Srivastava AK, Ray U
Journal of virology 2024 Dec 17;98(12):e0141824
Journal of virology 2024 Dec 17;98(12):e0141824
LRH-1 activation alleviates diabetes-induced podocyte injury by promoting GLS2-mediated glutaminolysis.
Hu J, Zhang Z, Hu H, Yang K, Zhu Z, Yang Q, Liang W
Cell proliferation 2023 Nov;56(11):e13479
Cell proliferation 2023 Nov;56(11):e13479
NR5A2 as a potential target for exercise to improve metabolic syndrome.
Meng L, Dong F, Deng J
Aging 2023 Mar 26;15(7):2485-2502
Aging 2023 Mar 26;15(7):2485-2502
miR-27a-3p targets NR5A2 to regulate CYP19A1 expression and 17-β estradiol synthesis in ovine granulosa cells.
Gui H, Li F, Chen C, Zhu Q, Zhang C, Zhang J, Meng C, Qian Y, Cao S, Li Y
Animal reproduction science 2023 Jan;248:107160
Animal reproduction science 2023 Jan;248:107160
NR5A2 Is One of 12 Transcription Factors Predicting Prognosis in HNSCC and Regulates Cancer Cell Proliferation in a p53-Dependent Manner.
Zhang K, Xiao M, Jin X, Jiang H
Frontiers in oncology 2021;11:691318
Frontiers in oncology 2021;11:691318
NR5A2 transcriptional activation by BRD4 promotes pancreatic cancer progression by upregulating GDF15.
Guo F, Zhou Y, Guo H, Ren D, Jin X, Wu H
Cell death discovery 2021 Apr 13;7(1):78
Cell death discovery 2021 Apr 13;7(1):78
Geniposide reduces cholesterol accumulation and increases its excretion by regulating the FXR-mediated liver-gut crosstalk of bile acids.
Liu J, Li Y, Sun C, Liu S, Yan Y, Pan H, Fan M, Xue L, Nie C, Zhang H, Qian H, Ying H, Wang L
Pharmacological research 2020 Feb;152:104631
Pharmacological research 2020 Feb;152:104631
MicroRNA-3613-5p Promotes Lung Adenocarcinoma Cell Proliferation through a RELA and AKT/MAPK Positive Feedback Loop.
He T, Shen H, Wang S, Wang Y, He Z, Zhu L, Du X, Wang D, Li J, Zhong S, Huang W, Yang H
Molecular therapy. Nucleic acids 2020 Dec 4;22:572-583
Molecular therapy. Nucleic acids 2020 Dec 4;22:572-583
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- rat testis tissue were subjected to SDS PAGE followed by western blot with 22460-1-AP( NR5A2 Antibody) at dilution of 1:600
- Other comments
- WB
