681202

antibody from BioLegend
Targeting: NR5A2 B1F2, FTF, FTZ-F1, FTZ-F1beta, hB1F, hB1F-2, LRH-1, LRH1
Provider product page for 681202

Antibody data

Product number
681202 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#681202, RRID:AB_2566455
Product name
Purified anti-NR5A2
Antibody type
Monoclonal
Antigen
Partial human NR5A2 recombinant protein (1-200 a.a.) expressed in E. coli.
Description
The nuclear receptor subfamily 5 group A member 2, also known as NR5A2, is a 54 kD nuclear receptor protein. NR5A2 is a member of the FTZ-F1 sub-family and is highly expressed in the pancreas and to a lesser extent in the liver. NR5A2 contains a DNA binding domain, a hormone ligand-binding domain, and two zinc finger domains. It also binds to DNA as a monomer. NR5A2 is known to regulate the transcription of the liver enzyme cholesterol 7-alpha-hydrolase, which converts cholesterol to bile acids and also activates the hepatitis B virus enhancer II to contribute to the liver-specific expression of this virus. NR5A2 has been suggested to regulate pancreas-specific gene expression and to play a role in embryonic development. There are at least 3 alternatively spliced isoforms of NR5A2: isoforms 1 and 2 are present in fetal and adult liver and in liver cancer cells HepG2 as well.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antibody clone number
1D12B67
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
2°C-8°C
Handling
Ambient RT
NR5A2 protein structure - 681202 shown in red.