PP-H2325-00
antibody from R&D Systems
Targeting: NR5A2
B1F2, FTF, FTZ-F1, FTZ-F1beta, hB1F, hB1F-2, LRH-1, LRH1
Antibody data
- Antibody Data
- Antigen structure
- References [6]
- Comments [0]
- Validations [0]
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- Product number
- PP-H2325-00 - Provider product page
- Provider
- R&D Systems
- Product name
- Human LRH-1/NR5A2 Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. This antibody specifically recognizes human LRH-1 alpha and LRH-1 beta and cross-reacts with mouse and rat LRH-1. Not yet tested in other species.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- H2325
- Vial size
- 100 ug
- Storage
- This antibody is stable for greater than six months when held at -20 °C in a manual defrost freezer or at -70 °C. Upon thawing, the antibody can be stored at 2-8 °C for at least 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Submitted references LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival.
LRH-1 regulates hepatic lipid homeostasis and maintains arachidonoyl phospholipid pools critical for phospholipid diversity.
Hepatocyte nuclear receptor SHP suppresses inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis.
Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs.
LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function.
A genome-wide screen in EpiSCs identifies Nr5a nuclear receptors as potent inducers of ground state pluripotency.
Bayrer JR, Wang H, Nattiv R, Suzawa M, Escusa HS, Fletterick RJ, Klein OD, Moore DD, Ingraham HA
Nature communications 2018 Oct 10;9(1):4055
Nature communications 2018 Oct 10;9(1):4055
LRH-1 regulates hepatic lipid homeostasis and maintains arachidonoyl phospholipid pools critical for phospholipid diversity.
Miranda DA, Krause WC, Cazenave-Gassiot A, Suzawa M, Escusa H, Foo JC, Shihadih DS, Stahl A, Fitch M, Nyangau E, Hellerstein M, Wenk MR, Silver DL, Ingraham HA
JCI insight 2018 Mar 8;3(5)
JCI insight 2018 Mar 8;3(5)
Hepatocyte nuclear receptor SHP suppresses inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis.
Zou A, Magee N, Deng F, Lehn S, Zhong C, Zhang Y
The Journal of biological chemistry 2018 Jun 1;293(22):8656-8671
The Journal of biological chemistry 2018 Jun 1;293(22):8656-8671
Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs.
Bayrer JR, Mukkamala S, Sablin EP, Webb P, Fletterick RJ
Proceedings of the National Academy of Sciences of the United States of America 2015 Feb 24;112(8):2467-72
Proceedings of the National Academy of Sciences of the United States of America 2015 Feb 24;112(8):2467-72
LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function.
Holmstrom SR, Deering T, Swift GH, Poelwijk FJ, Mangelsdorf DJ, Kliewer SA, MacDonald RJ
Genes & development 2011 Aug 15;25(16):1674-9
Genes & development 2011 Aug 15;25(16):1674-9
A genome-wide screen in EpiSCs identifies Nr5a nuclear receptors as potent inducers of ground state pluripotency.
Guo G, Smith A
Development (Cambridge, England) 2010 Oct;137(19):3185-92
Development (Cambridge, England) 2010 Oct;137(19):3185-92
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