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- References [93]
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- Product number
- 13473-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13473-1-AP, RRID:AB_2287023
- Product name
- HRD1/SYVN1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated HRD1/SYVN1 antibody (Cat. #13473-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Tripartite motif 13 orchestrates endoplasmic reticulum-associated degradation and endoplasmic reticulum-phagy to modulate dendritic cell-mediated immune responses in sepsis.
Functional rescue of a disease-linked ERAD pathway mutation via alternative splicing.
Ginsenoside Rb1 Targets the HRD1-STING Axis to Mitigate Cholesterol-Induced VSMC Senescence.
Structural basis and pathological implications of the dimeric OS9-SEL1L-HRD1 ERAD Core Complex.
MCM8 promotes colorectal cancer progression by competitively inhibiting HRD1-mediated CDC42 ubiquitination and degradation.
SEL1L-HRD1 ER-associated degradation facilitates prohormone convertase 2 maturation and glucagon production in islet α cells.
Functional integrity of the SEL1L-HRD1 complex is critical for endoplasmic reticulum-associated degradation and organismal viability.
Neuronal SEL1L-HRD1 ER-associated degradation is essential for motor function and survival in mice.
eIF3f promotes tumour malignancy by remodelling fatty acid biosynthesis in hepatocellular carcinoma.
IRE1α translational suppression potentiates STING-dependent chemoresistance in pancreatic cancer.
MYC affects mitochondrial function in IgA nephropathy by promoting the degradation of MFN1 through HRD1.
INHBA promotes chemoresistance in pancreatic cancer by enhancing CTPS1 stability and mediating pyrimidine metabolism.
SEL1L-HRD1 ER-Associated Degradation Facilitates Prohormone Convertase 2 Maturation and Glucagon Production in Islet α Cells.
GRASP55 regulates sorting and maturation of the lysosomal enzyme β-hexosaminidase A.
VDAC1 is a target for pharmacologically induced insulin hypersecretion in β cells.
Neuronal SEL1L-HRD1 ERAD regulates one-carbon metabolism and is essential for motor function and survival.
The ER-associated degradation adaptor SEL1L is dispensable for ER homeostasis and the differentiation of spermatogenic cells.
Capsaicin Inhibits Ferroptosis through Facilitating SYVN1-Mediated Ubiquitination and Degradation of ACSL4.
Structural insights into the human HRD1 ubiquitin ligase complex.
Targeting EGFR-binding protein SLC7A11 enhancing antitumor immunity of T cells via inducing MHC-I antigen presentation in nasopharyngeal carcinoma.
Ubiquitination by HRD1 is essential for TLR3 trafficking and its innate immune signaling.
Targeting the SYVN1-EGFR axis: a breakthrough strategy for TKI-resistant NSCLC.
UPF1 Alleviates Myocardial Ischemia-Reperfusion Injury by Regulating SMURF2-Mediated Ubiquitination Degradation of FOXA2.
Requirements for nuclear GRP78 transcriptional regulatory activities and interaction with nuclear GRP94.
The p97-UBXD8 complex maintains peroxisome abundance by suppressing pexophagy.
The Delayed Turnover of Proteasome Processing of Myocilin upon Dexamethasone Stimulation Introduces the Profiling of Trabecular Meshwork Cells' Ubiquitylome.
Promotion of endoplasmic reticulum retrotranslocation by overexpression of E3 ubiquitin-protein ligase synoviolin 1 reduces endoplasmic reticulum stress and preserves cone photoreceptors in cyclic nucleotide-gated channel deficiency.
Attenuation of renal fibrosis in mice due to lack of bombesin receptor-activated protein homologue.
Arsenic trioxide and p97 inhibitor synergize against acute myeloid leukemia by targeting nascent polypeptides and activating the ZAKα-JNK pathway.
Pharmacological chaperones restore proteostasis of epilepsy-associated GABA(A) receptor variants.
siRNA/CS-PLGA Nanoparticle System Targeting Knockdown Intestinal SOAT2 Reduced Intestinal Lipid Uptake and Alleviated Obesity.
Regulation of hepatic inclusions and fibrinogen biogenesis by SEL1L-HRD1 ERAD.
Characterization of PANoptosis-related genes with immunoregulatory features in osteoarthritis.
GRASP55 Regulates Sorting and Maturation of the Lysosomal Enzyme β-Hexosaminidase A.
HRD1 reduction promotes cholesterol-induced vascular smooth muscle cell phenotypic change via endoplasmic reticulum stress.
Purkinje cell-specific deficiency in SEL1L-hrd1 endoplasmic reticulum-associated degradation causes progressive cerebellar ataxia in mice.
The HRD1-SEL1L ubiquitin ligase regulates stress granule homeostasis in couple with distinctive signaling branches of ER stress.
Proteomic screens of SEL1L-HRD1 ER-associated degradation substrates reveal its role in glycosylphosphatidylinositol-anchored protein biogenesis.
Biallelic Cys141Tyr variant of SEL1L is associated with neurodevelopmental disorders, agammaglobulinemia, and premature death.
Hypomorphic variants of SEL1L-HRD1 ER-associated degradation are associated with neurodevelopmental disorders.
Cholesterol-induced HRD1 reduction accelerates vascular smooth muscle cell senescence via stimulation of endoplasmic reticulum stress-induced reactive oxygen species.
HRD1-induced TMEM2 ubiquitination promotes ER stress-mediated apoptosis through a non-canonical pathway in intestinal ischemia/reperfusion.
SEL1L-HRD1 interaction is required to form a functional HRD1 ERAD complex.
Hepatitis B virus core protein stabilizes RANGAP1 to upregulate KDM2A and facilitate hepatocarcinogenesis.
Fufang Luohanguo Qingfei granules reduces influenza virus susceptibility via MAVS-dependent type I interferon antiviral signaling.
Inhibition of Ryanodine Receptor 1 Reduces Endoplasmic Reticulum (ER) Stress and Promotes ER Protein Degradation in Cyclic Nucleotide-Gated Channel Deficiency.
Large HBV Surface Protein-Induced Unfolded Protein Response Dynamically Regulates p27 Degradation in Hepatocellular Carcinoma Progression.
Exogenous H(2)S initiating Nrf2/GPx4/GSH pathway through promoting Syvn1-Keap1 interaction in diabetic hearts.
ER-associated degradation in cystinosis pathogenesis and the prospects of precision medicine.
Involvement of Proteasomal and Endoplasmic Reticulum Stress in Neurodegeneration After Global Brain Ischemia.
UFMylation of HRD1 regulates endoplasmic reticulum homeostasis.
Role of a holo-insertase complex in the biogenesis of biophysically diverse ER membrane proteins.
SEL1L-HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool.
The mechanisms to dispose of misfolded proteins in the endoplasmic reticulum of adipocytes.
The Brucella abortus Type IV Effector BspA Inhibits MARCH6-Dependent ERAD To Promote Intracellular Growth.
Perturbation of endoplasmic reticulum proteostasis triggers tissue injury in the thyroid gland.
Characterization of dietary and herbal sourced natural compounds that modulate SEL1L-HRD1 ERAD activity and alleviate protein misfolding in the ER.
Hepatic SEL1L-HRD1 ER-associated degradation regulates systemic iron homeostasis via ceruloplasmin.
The p97-UBXD8 complex regulates ER-Mitochondria contact sites by altering membrane lipid saturation and composition.
Exogenous H(2) S promotes ubiquitin-mediated degradation of SREBP1 to alleviate diabetic cardiomyopathy via SYVN1 S-sulfhydration.
Role of SYVN1 in the control of airway remodeling in asthma protection by promoting SIRT2 ubiquitination and degradation.
4-phenylbutyric acid re-trafficking hERG/G572R channel protein by modulating the endoplasmic reticulum stress-associated chaperones and endoplasmic reticulum-associated degradation gene.
Muscle-specific ER-associated degradation maintains postnatal muscle hypertrophy and systemic energy metabolism.
Pharmacological chaperones restore proteostasis of epilepsy-associated GABA(A) receptor variants.
Bombesin receptor-activated protein exacerbates cisplatin-induced AKI by regulating the degradation of SIRT2.
Endoplasmic reticulum stress induces mitochondrial dysfunction but not mitochondrial unfolded protein response in SH-SY5Y cells.
S100A16 promotes acute kidney injury by activating HRD1-induced ubiquitination and degradation of GSK3β and CK1α.
AAA-ATPase valosin-containing protein binds the transcription factor SREBP1 and promotes its proteolytic activation by rhomboid protease RHBDL4.
Sigma-1 receptor attenuates osteoclastogenesis by promoting ER-associated degradation of SERCA2.
SYVN1-MTR4-MAT2A Signaling Axis Regulates Methionine Metabolism in Glioma Cells.
Ginsenoside Rb1 alleviates colitis in mice via activation of endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 signaling pathway.
Hydrogen sulphide reduced the accumulation of lipid droplets in cardiac tissues of db/db mice via Hrd1 S-sulfhydration.
PGRMC1 acts as a size-selective cargo receptor to drive ER-phagic clearance of mutant prohormones.
Preservation of endoplasmic reticulum (ER) Ca(2+) stores by deletion of inositol-1,4,5-trisphosphate receptor type 1 promotes ER retrotranslocation, proteostasis, and protein outer segment localization in cyclic nucleotide-gated channel-deficient cone photoreceptors.
CircNR3C2 promotes HRD1-mediated tumor-suppressive effect via sponging miR-513a-3p in triple-negative breast cancer.
THADA drives Golgi residency and upregulation of PD-L1 in cancer cells and provides promising target for immunotherapy.
SEL1L degradation intermediates stimulate cytosolic aggregation of polyglutamine-expanded protein.
STING regulates BCR signaling in normal and malignant B cells.
Endoplasmic reticulum-associated degradation is required for nephrin maturation and kidney glomerular filtration function.
ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia.
Reticulon protects the integrity of the ER membrane during ER escape of large macromolecular protein complexes.
Cross-talks of glycosylphosphatidylinositol biosynthesis with glycosphingolipid biosynthesis and ER-associated degradation.
Exogenous H(2)S Induces Hrd1 S-sulfhydration and Prevents CD36 Translocation via VAMP3 Ubiquitylation in Diabetic Hearts.
Cells Deploy a Two-Pronged Strategy to Rectify Misfolded Proinsulin Aggregates.
Redundant and Antagonistic Roles of XTP3B and OS9 in Decoding Glycan and Non-glycan Degrons in ER-Associated Degradation.
The ubiquitin-proteasome system functionally links neuronal Tomosyn-1 to dendritic morphology.
AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity.
Endoplasmic Reticulum Stress Induces HRD1 to Protect Alveolar Type II Epithelial Cells from Apoptosis Induced by Cigarette Smoke Extract.
Characterization of protein complexes of the endoplasmic reticulum-associated degradation E3 ubiquitin ligase Hrd1.
PDI reductase acts on Akita mutant proinsulin to initiate retrotranslocation along the Hrd1/Sel1L-p97 axis.
A cytosolic chaperone complexes with dynamic membrane J-proteins and mobilizes a nonenveloped virus out of the endoplasmic reticulum.
A deubiquitinase negatively regulates retro-translocation of nonubiquitinated substrates.
The ERdj5-Sel1L complex facilitates cholera toxin retrotranslocation.
Tong S, Zhang T, Chen N, Liu JP, Wei ST, Hua TZ, Duan Y, Sun B, Dong N, Wu Y, Zhu XM, Yao YM
Burns & trauma 2026;14:tkaf077
Burns & trauma 2026;14:tkaf077
Functional rescue of a disease-linked ERAD pathway mutation via alternative splicing.
Wang HH, Wang Z, Lin LL, Verma SK, Gniadzik W, Wang H, Li ZJ, Whitestone E, Jiang L, Kuyumcu-Martinez MN, Sun S, Qi L
The EMBO journal 2026 May;45(9):3230-3251
The EMBO journal 2026 May;45(9):3230-3251
Ginsenoside Rb1 Targets the HRD1-STING Axis to Mitigate Cholesterol-Induced VSMC Senescence.
Niu H, Cai Y, Yu C, Lin N, Chen M, Wang L
Journal of clinical laboratory analysis 2026 Mar;40(5):e70172
Journal of clinical laboratory analysis 2026 Mar;40(5):e70172
Structural basis and pathological implications of the dimeric OS9-SEL1L-HRD1 ERAD Core Complex.
Lin LL, Maldosevic E, Zhou LE, Jomaa A, Qi L
Nature communications 2026 Jan 27;17(1)
Nature communications 2026 Jan 27;17(1)
MCM8 promotes colorectal cancer progression by competitively inhibiting HRD1-mediated CDC42 ubiquitination and degradation.
Qian S, Zeng L, Chen F, Tian Y, Zhao B, Liu Q, Zhang B
Journal of translational medicine 2026 Jan 16;24(1)
Journal of translational medicine 2026 Jan 16;24(1)
SEL1L-HRD1 ER-associated degradation facilitates prohormone convertase 2 maturation and glucagon production in islet α cells.
Zhu W, Pan L, Cui X, Russo AC, Ray R, Pederson B, Wei X, Lin LL, Torres M, Hafner H, Gregg B, Shrestha N, Liu C, Naji A, Arvan P, Sandoval DA, Lindberg I, Qi L, Reinert RB
Nature communications 2026 Feb 25;17(1)
Nature communications 2026 Feb 25;17(1)
Functional integrity of the SEL1L-HRD1 complex is critical for endoplasmic reticulum-associated degradation and organismal viability.
Zhang X, Lin LL, Pan L, Wei X, Wang HH, Li ZJ, Qi L
Proceedings of the National Academy of Sciences of the United States of America 2026 Feb 10;123(6):e2517927123
Proceedings of the National Academy of Sciences of the United States of America 2026 Feb 10;123(6):e2517927123
Neuronal SEL1L-HRD1 ER-associated degradation is essential for motor function and survival in mice.
Torres M, Lu Y, Pederson B, Wang H, Gretzinger A, Lin LL, Hwang J, Chen X, Rupp AC, Tomlinson AJ, Scott AJ, Zhao Z, Wahl DR, Myers MG Jr, Lyssiotis CA, Qi L
The Journal of clinical investigation 2026 Apr 15;136(8)
The Journal of clinical investigation 2026 Apr 15;136(8)
eIF3f promotes tumour malignancy by remodelling fatty acid biosynthesis in hepatocellular carcinoma.
Zhou S, Zhang L, You Y, Yu K, Tie X, Gao Y, Chen Y, Yao F, Zhang R, Hao X, Fang C, Li X, Li Q, Wang X
Journal of hepatology 2025 Sep;83(3):712-728
Journal of hepatology 2025 Sep;83(3):712-728
IRE1α translational suppression potentiates STING-dependent chemoresistance in pancreatic cancer.
Luo Y, Sun M, Chang L, He Z, Zhou X, Yuan Y, Sun H, Luo S, Huang J, Wu H, Liu W, Zhou Z, Mao Y, Ji Y, Liang T
Cell death & disease 2025 Oct 6;16(1):680
Cell death & disease 2025 Oct 6;16(1):680
MYC affects mitochondrial function in IgA nephropathy by promoting the degradation of MFN1 through HRD1.
Wu X, Liu L, Zhao R, Chen W
Immunologic research 2025 Nov 15;73(1):166
Immunologic research 2025 Nov 15;73(1):166
INHBA promotes chemoresistance in pancreatic cancer by enhancing CTPS1 stability and mediating pyrimidine metabolism.
Sun X, Wei Z, Liao X, Zheng D, Li F, Chen L, Gong Y, Ran S, Han X, He Z, Yu C
Cancer cell international 2025 Nov 14;25(1):403
Cancer cell international 2025 Nov 14;25(1):403
SEL1L-HRD1 ER-Associated Degradation Facilitates Prohormone Convertase 2 Maturation and Glucagon Production in Islet α Cells.
Zhu W, Pan L, Cui X, Russo AC, Ray R, Pederson B, Wei X, Lin LL, Hafner H, Gregg B, Shrestha N, Liu C, Naji A, Arvan P, Sandoval DA, Lindberg I, Qi L, Reinert RB
bioRxiv : the preprint server for biology 2025 Mar 20;
bioRxiv : the preprint server for biology 2025 Mar 20;
GRASP55 regulates sorting and maturation of the lysosomal enzyme β-hexosaminidase A.
Akaaboune SR, Javed A, Bui S, Wierenga A, Wang Y
Molecular biology of the cell 2025 Mar 1;36(3):ar30
Molecular biology of the cell 2025 Mar 1;36(3):ar30
VDAC1 is a target for pharmacologically induced insulin hypersecretion in β cells.
Roy G, Ordóñez A, Binns DD, Rodrigues-Dos-Santos K, Kwakye MB, King GC, Kuntz RL, Mukherjee N, Templin AT, Tan Z, Richardson TI, Doud EH, Mosley AL, Schueler KL, Emfinger CH, Attie AD, Keller MP, Johnson TS, Kalwat MA
Cell reports 2025 Jun 24;44(6):115834
Cell reports 2025 Jun 24;44(6):115834
Neuronal SEL1L-HRD1 ERAD regulates one-carbon metabolism and is essential for motor function and survival.
Torres M, Lu Y, Pederson B, Wang H, Gretzinger A, Lin LL, Hwang J, Rupp A, Tomlinson A, Scott AJ, Zhao Z, Wahl DR, Myers M, Lyssiotis CA, Qi L
bioRxiv : the preprint server for biology 2025 Jun 18;
bioRxiv : the preprint server for biology 2025 Jun 18;
The ER-associated degradation adaptor SEL1L is dispensable for ER homeostasis and the differentiation of spermatogenic cells.
Tushi NJ, Zhang Z, Sun S
The Journal of biological chemistry 2025 Jul;301(7):110283
The Journal of biological chemistry 2025 Jul;301(7):110283
Capsaicin Inhibits Ferroptosis through Facilitating SYVN1-Mediated Ubiquitination and Degradation of ACSL4.
Yang X, Zhang Z, Wang F, Dong X, Huang S, Ren X, Yao X, Dahms HU, Li Y, Yang J
Journal of agricultural and food chemistry 2025 Jul 23;73(29):18437-18447
Journal of agricultural and food chemistry 2025 Jul 23;73(29):18437-18447
Structural insights into the human HRD1 ubiquitin ligase complex.
Guo L, Liu G, He J, Jia X, He Y, Wang Z, Qian H
Nature communications 2025 Jul 1;16(1):6007
Nature communications 2025 Jul 1;16(1):6007
Targeting EGFR-binding protein SLC7A11 enhancing antitumor immunity of T cells via inducing MHC-I antigen presentation in nasopharyngeal carcinoma.
Wang H, Fan S, Zhan Y, Xu Y, Du Y, Luo J, Zang H, Peng S, Wang W
Cell death & disease 2025 Jan 16;16(1):21
Cell death & disease 2025 Jan 16;16(1):21
Ubiquitination by HRD1 is essential for TLR3 trafficking and its innate immune signaling.
Zhao L, He Z, Sun Y, Sun M, Liu Z, Zhou Z, Qi L, Luo Y, Ji Y, Liang T
Nature communications 2025 Dec 10;17(1):525
Nature communications 2025 Dec 10;17(1):525
Targeting the SYVN1-EGFR axis: a breakthrough strategy for TKI-resistant NSCLC.
Xie X, Tong W, Xie Y, Jiang H, Jiang A, Huang J, Liu Z, Yu J
Cell death & disease 2025 Aug 28;16(1):655
Cell death & disease 2025 Aug 28;16(1):655
UPF1 Alleviates Myocardial Ischemia-Reperfusion Injury by Regulating SMURF2-Mediated Ubiquitination Degradation of FOXA2.
Li A, Li P, Mu C, Li D, Chen K, Liang Z
Korean circulation journal 2025 Apr;55(4):305-321
Korean circulation journal 2025 Apr;55(4):305-321
Requirements for nuclear GRP78 transcriptional regulatory activities and interaction with nuclear GRP94.
Liu Z, Ha DP, Lin LL, Qi L, Lee AS
The Journal of biological chemistry 2025 Apr;301(4):108369
The Journal of biological chemistry 2025 Apr;301(4):108369
The p97-UBXD8 complex maintains peroxisome abundance by suppressing pexophagy.
Montes ID, Amirthagunanathan S, Joshi AS, Raman M
bioRxiv : the preprint server for biology 2024 Sep 26;
bioRxiv : the preprint server for biology 2024 Sep 26;
The Delayed Turnover of Proteasome Processing of Myocilin upon Dexamethasone Stimulation Introduces the Profiling of Trabecular Meshwork Cells' Ubiquitylome.
Tundo GR, Cavaterra D, Pandino I, Zingale GA, Giammaria S, Boccaccini A, Michelessi M, Roberti G, Tanga L, Carnevale C, Figus M, Grasso G, Coletta M, Bocedi A, Oddone F, Sbardella D
International journal of molecular sciences 2024 Sep 17;25(18)
International journal of molecular sciences 2024 Sep 17;25(18)
Promotion of endoplasmic reticulum retrotranslocation by overexpression of E3 ubiquitin-protein ligase synoviolin 1 reduces endoplasmic reticulum stress and preserves cone photoreceptors in cyclic nucleotide-gated channel deficiency.
Yang F, Ma H, Boye SL, Boye SE, Ding XQ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Sep 15;38(17):e70021
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Sep 15;38(17):e70021
Attenuation of renal fibrosis in mice due to lack of bombesin receptor-activated protein homologue.
Peng Z, Wang H, Zheng J, Chen H, Wang J, Weber HC, Yuan L, Qin X, Xiang Y, Liu C, Ji M, Liu H, Qu X
Clinical and experimental pharmacology & physiology 2024 Oct;51(10):e13916
Clinical and experimental pharmacology & physiology 2024 Oct;51(10):e13916
Arsenic trioxide and p97 inhibitor synergize against acute myeloid leukemia by targeting nascent polypeptides and activating the ZAKα-JNK pathway.
Xie S, Liu H, Zhu S, Chen Z, Wang R, Zhang W, Xian H, Xiang R, Xia X, Sun Y, Long J, Wang Y, Wang M, Wang Y, Yu Y, Huang Z, Lu C, Xu Z, Liu H
Cancer gene therapy 2024 Oct;31(10):1486-1497
Cancer gene therapy 2024 Oct;31(10):1486-1497
Pharmacological chaperones restore proteostasis of epilepsy-associated GABA(A) receptor variants.
Wang YJ, Seibert H, Ahn LY, Schaffer AE, Mu TW
Pharmacological research 2024 Oct;208:107356
Pharmacological research 2024 Oct;208:107356
siRNA/CS-PLGA Nanoparticle System Targeting Knockdown Intestinal SOAT2 Reduced Intestinal Lipid Uptake and Alleviated Obesity.
Liang J, Shao W, Ni P, Liu Q, Kong W, Shen W, Wang Q, Huang A, Zhang G, Yang Y, Xin H, Jiang Z, Gu A
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(40):e2403442
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(40):e2403442
Regulation of hepatic inclusions and fibrinogen biogenesis by SEL1L-HRD1 ERAD.
Song Z, Thepsuwan P, Hur WS, Torres M, Wu SA, Wei X, Tushi NJ, Wei J, Ferraresso F, Paton AW, Paton JC, Zheng Z, Zhang K, Fang D, Kastrup CJ, Jaiman S, Flick MJ, Sun S
Nature communications 2024 Oct 26;15(1):9244
Nature communications 2024 Oct 26;15(1):9244
Characterization of PANoptosis-related genes with immunoregulatory features in osteoarthritis.
Lan Z, Yang Y, Sun R, Lin X, Yan J, Chen X, Tian K, Wu G, Saad M, Wu Z, Xue D, Jin Q
International immunopharmacology 2024 Oct 25;140:112889
International immunopharmacology 2024 Oct 25;140:112889
GRASP55 Regulates Sorting and Maturation of the Lysosomal Enzyme β-Hexosaminidase A.
Akaaboune SR, Javed A, Bui S, Wierenga A, Wang Y
bioRxiv : the preprint server for biology 2024 Oct 17;
bioRxiv : the preprint server for biology 2024 Oct 17;
HRD1 reduction promotes cholesterol-induced vascular smooth muscle cell phenotypic change via endoplasmic reticulum stress.
Wang L, Ren Z, Wu L, Zhang X, Wang M, Niu H, He X, Wang H, Chen Y, Shi G, Qian X
Molecular and cellular biochemistry 2024 Nov;479(11):3021-3036
Molecular and cellular biochemistry 2024 Nov;479(11):3021-3036
Purkinje cell-specific deficiency in SEL1L-hrd1 endoplasmic reticulum-associated degradation causes progressive cerebellar ataxia in mice.
Torres M, Pederson B, Wang H, Lin LL, Wang HH, Bugarin-Lapuz A, Zhao Z, Qi L
JCI insight 2024 Nov 8;9(21)
JCI insight 2024 Nov 8;9(21)
The HRD1-SEL1L ubiquitin ligase regulates stress granule homeostasis in couple with distinctive signaling branches of ER stress.
Shi W, Ding R, Chen Y, Ji F, Ji J, Ma W, Jin J
iScience 2024 Jul 19;27(7):110196
iScience 2024 Jul 19;27(7):110196
Proteomic screens of SEL1L-HRD1 ER-associated degradation substrates reveal its role in glycosylphosphatidylinositol-anchored protein biogenesis.
Wei X, Lu Y, Lin LL, Zhang C, Chen X, Wang S, Wu SA, Li ZJ, Quan Y, Sun S, Qi L
Nature communications 2024 Jan 22;15(1):659
Nature communications 2024 Jan 22;15(1):659
Biallelic Cys141Tyr variant of SEL1L is associated with neurodevelopmental disorders, agammaglobulinemia, and premature death.
Weis D, Lin LL, Wang HH, Li ZJ, Kusikova K, Ciznar P, Wolf HM, Leiss-Piller A, Wang Z, Wei X, Weis S, Skalicka K, Hrckova G, Danisovic L, Soltysova A, Yang TT, Feichtinger RG, Mayr JA, Qi L
The Journal of clinical investigation 2024 Jan 16;134(2)
The Journal of clinical investigation 2024 Jan 16;134(2)
Hypomorphic variants of SEL1L-HRD1 ER-associated degradation are associated with neurodevelopmental disorders.
Wang HH, Lin LL, Li ZJ, Wei X, Askander O, Cappuccio G, Hashem MO, Hubert L, Munnich A, Alqahtani M, Pang Q, Burmeister M, Lu Y, Poirier K, Besmond C, Sun S, Brunetti-Pierri N, Alkuraya FS, Qi L
The Journal of clinical investigation 2024 Jan 16;134(2)
The Journal of clinical investigation 2024 Jan 16;134(2)
Cholesterol-induced HRD1 reduction accelerates vascular smooth muscle cell senescence via stimulation of endoplasmic reticulum stress-induced reactive oxygen species.
Wang L, Wang M, Niu H, Zhi Y, Li S, He X, Ren Z, Wen S, Wu L, Wen S, Zhang R, Wen Z, Yang J, Zhang X, Chen Y, Qian X, Shi G
Journal of molecular and cellular cardiology 2024 Feb;187:51-64
Journal of molecular and cellular cardiology 2024 Feb;187:51-64
HRD1-induced TMEM2 ubiquitination promotes ER stress-mediated apoptosis through a non-canonical pathway in intestinal ischemia/reperfusion.
Zhao X, Liu D, Zhao Y, Wang Z, Wang Y, Chen Z, Ning S, Wang G, Meng L, Yao J, Tian X
Cell death & disease 2024 Feb 20;15(2):154
Cell death & disease 2024 Feb 20;15(2):154
SEL1L-HRD1 interaction is required to form a functional HRD1 ERAD complex.
Lin LL, Wang HH, Pederson B, Wei X, Torres M, Lu Y, Li ZJ, Liu X, Mao H, Wang H, Zhou LE, Zhao Z, Sun S, Qi L
Nature communications 2024 Feb 16;15(1):1440
Nature communications 2024 Feb 16;15(1):1440
Hepatitis B virus core protein stabilizes RANGAP1 to upregulate KDM2A and facilitate hepatocarcinogenesis.
You HJ, Ma LH, Wang X, Wang YX, Zhang HY, Bao ES, Zhong YJ, Liu XY, Kong DL, Zheng KY, Kong FY, Tang RX
Cellular oncology (Dordrecht, Netherlands) 2024 Apr;47(2):639-655
Cellular oncology (Dordrecht, Netherlands) 2024 Apr;47(2):639-655
Fufang Luohanguo Qingfei granules reduces influenza virus susceptibility via MAVS-dependent type I interferon antiviral signaling.
Lu YH, Wang M, Lin JQ, Wang MY, Zhou LY, He SH, Yi YT, Wei X, Huang QJ, Su ZH, Yang J, Guo HW, He RR, Luo Z
Journal of ethnopharmacology 2024 Apr 24;324:117780
Journal of ethnopharmacology 2024 Apr 24;324:117780
Inhibition of Ryanodine Receptor 1 Reduces Endoplasmic Reticulum (ER) Stress and Promotes ER Protein Degradation in Cyclic Nucleotide-Gated Channel Deficiency.
Yang F, Ma H, Garg R, Lewin A, Ding XQ
Advances in experimental medicine and biology 2023;1415:353-358
Advances in experimental medicine and biology 2023;1415:353-358
Large HBV Surface Protein-Induced Unfolded Protein Response Dynamically Regulates p27 Degradation in Hepatocellular Carcinoma Progression.
Guo Y, Shao J, Zhang R, Han M, Kong L, Liu Z, Li H, Wei D, Lu M, Zhang S, Zhang C, Wei H, Chen Z, Bian H
International journal of molecular sciences 2023 Sep 7;24(18)
International journal of molecular sciences 2023 Sep 7;24(18)
Exogenous H(2)S initiating Nrf2/GPx4/GSH pathway through promoting Syvn1-Keap1 interaction in diabetic hearts.
Wang M, Tang J, Zhang S, Pang K, Zhao Y, Liu N, Huang J, Kang J, Dong S, Li H, Tian Z, Duan B, Lu F, Zhang W
Cell death discovery 2023 Oct 24;9(1):394
Cell death discovery 2023 Oct 24;9(1):394
ER-associated degradation in cystinosis pathogenesis and the prospects of precision medicine.
Venkatarangan V, Zhang W, Yang X, Thoene J, Hahn SH, Li M
The Journal of clinical investigation 2023 Oct 2;133(19)
The Journal of clinical investigation 2023 Oct 2;133(19)
Involvement of Proteasomal and Endoplasmic Reticulum Stress in Neurodegeneration After Global Brain Ischemia.
Ziakova K, Kovalska M, Pilchova I, Dibdiakova K, Brodnanova M, Pokusa M, Kalenska D, Racay P
Molecular neurobiology 2023 Nov;60(11):6316-6329
Molecular neurobiology 2023 Nov;60(11):6316-6329
UFMylation of HRD1 regulates endoplasmic reticulum homeostasis.
Luo H, Jiao QB, Shen CB, Gong WY, Yuan JH, Liu YY, Chen Z, Liu J, Xu XL, Cong YS, Zhang XW
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Nov;37(11):e23221
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Nov;37(11):e23221
Role of a holo-insertase complex in the biogenesis of biophysically diverse ER membrane proteins.
Page KR, Nguyen VN, Pleiner T, Tomaleri GP, Wang ML, Guna A, Wang TY, Chou TF, Voorhees RM
bioRxiv : the preprint server for biology 2023 Nov 29;
bioRxiv : the preprint server for biology 2023 Nov 29;
SEL1L-HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool.
Ji Y, Luo Y, Wu Y, Sun Y, Zhao L, Xue Z, Sun M, Wei X, He Z, Wu SA, Lin LL, Lu Y, Chang L, Chen F, Chen S, Qian W, Xu X, Chen S, Pan D, Zhou Z, Xia S, Hu CA, Liang T, Qi L
Nature cell biology 2023 May;25(5):726-739
Nature cell biology 2023 May;25(5):726-739
The mechanisms to dispose of misfolded proteins in the endoplasmic reticulum of adipocytes.
Wu SA, Shen C, Wei X, Zhang X, Wang S, Chen X, Torres M, Lu Y, Lin LL, Wang HH, Hunter AH, Fang D, Sun S, Ivanova MI, Lin Y, Qi L
Nature communications 2023 May 30;14(1):3132
Nature communications 2023 May 30;14(1):3132
The Brucella abortus Type IV Effector BspA Inhibits MARCH6-Dependent ERAD To Promote Intracellular Growth.
Kambarev S, Borghesan E, Miller CN, Myeni S, Celli J
Infection and immunity 2023 May 16;91(5):e0013023
Infection and immunity 2023 May 16;91(5):e0013023
Perturbation of endoplasmic reticulum proteostasis triggers tissue injury in the thyroid gland.
Zhang X, Young C, Liao XH, Refetoff S, Torres M, Tomer Y, Stefan-Lifshitz M, Zhang H, Larkin D, Fang D, Qi L, Arvan P
JCI insight 2023 Jun 22;8(12)
JCI insight 2023 Jun 22;8(12)
Characterization of dietary and herbal sourced natural compounds that modulate SEL1L-HRD1 ERAD activity and alleviate protein misfolding in the ER.
Yang J, Zhi Y, Wen S, Pan X, Wang H, He X, Lu Y, Zhu Y, Chen Y, Shi G
The Journal of nutritional biochemistry 2023 Jan;111:109178
The Journal of nutritional biochemistry 2023 Jan;111:109178
Hepatic SEL1L-HRD1 ER-associated degradation regulates systemic iron homeostasis via ceruloplasmin.
Thepsuwan P, Bhattacharya A, Song Z, Hippleheuser S, Feng S, Wei X, Das NK, Sierra M, Wei J, Fang D, Huang YM, Zhang K, Shah YM, Sun S
Proceedings of the National Academy of Sciences of the United States of America 2023 Jan 10;120(2):e2212644120
Proceedings of the National Academy of Sciences of the United States of America 2023 Jan 10;120(2):e2212644120
The p97-UBXD8 complex regulates ER-Mitochondria contact sites by altering membrane lipid saturation and composition.
Ganji R, Paulo JA, Xi Y, Kline I, Zhu J, Clemen CS, Weihl CC, Purdy JG, Gygi SP, Raman M
Nature communications 2023 Feb 6;14(1):638
Nature communications 2023 Feb 6;14(1):638
Exogenous H(2) S promotes ubiquitin-mediated degradation of SREBP1 to alleviate diabetic cardiomyopathy via SYVN1 S-sulfhydration.
Zhang S, Wang M, Li H, Li Q, Liu N, Dong S, Zhao Y, Pang K, Huang J, Ren C, Wang Y, Tian Z, Lu F, Zhang W
Journal of cachexia, sarcopenia and muscle 2023 Dec;14(6):2719-2732
Journal of cachexia, sarcopenia and muscle 2023 Dec;14(6):2719-2732
Role of SYVN1 in the control of airway remodeling in asthma protection by promoting SIRT2 ubiquitination and degradation.
Dai B, Liu S, Shen W, Chen L, Zhou Q, Han L, Zhang Q, Shan L
Biological research 2023 Dec 2;56(1):64
Biological research 2023 Dec 2;56(1):64
4-phenylbutyric acid re-trafficking hERG/G572R channel protein by modulating the endoplasmic reticulum stress-associated chaperones and endoplasmic reticulum-associated degradation gene.
Tang W, Cai D, Fu Y, Zheng Z, Huang X, Khouzam RN, Song Y, Lian J
Journal of thoracic disease 2023 Aug 31;15(8):4472-4485
Journal of thoracic disease 2023 Aug 31;15(8):4472-4485
Muscle-specific ER-associated degradation maintains postnatal muscle hypertrophy and systemic energy metabolism.
Abdon B, Liang Y, da Luz Scheffer D, Torres M, Shrestha N, Reinert RB, Lu Y, Pederson B, Bugarin-Lapuz A, Kersten S, Qi L
JCI insight 2023 Aug 3;8(17)
JCI insight 2023 Aug 3;8(17)
Pharmacological chaperones restore proteostasis of epilepsy-associated GABA(A) receptor variants.
Wang YJ, Seibert H, Ahn LY, Schaffer AE, Mu TW
bioRxiv : the preprint server for biology 2023 Apr 19;
bioRxiv : the preprint server for biology 2023 Apr 19;
Bombesin receptor-activated protein exacerbates cisplatin-induced AKI by regulating the degradation of SIRT2.
Peng L, Liu D, Liu H, Xia M, Wan L, Li M, Zhao J, Tang C, Chen G, Qu X, Dong Z, Liu H
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2022 Nov 23;37(12):2366-2385
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2022 Nov 23;37(12):2366-2385
Endoplasmic reticulum stress induces mitochondrial dysfunction but not mitochondrial unfolded protein response in SH-SY5Y cells.
Evinova A, Hatokova Z, Tatarkova Z, Brodnanova M, Dibdiakova K, Racay P
Molecular and cellular biochemistry 2022 Mar;477(3):965-975
Molecular and cellular biochemistry 2022 Mar;477(3):965-975
S100A16 promotes acute kidney injury by activating HRD1-induced ubiquitination and degradation of GSK3β and CK1α.
Sun Y, Fan Y, Wang Z, Li M, Su D, Liu Y, Liang X
Cellular and molecular life sciences : CMLS 2022 Mar 12;79(3):184
Cellular and molecular life sciences : CMLS 2022 Mar 12;79(3):184
AAA-ATPase valosin-containing protein binds the transcription factor SREBP1 and promotes its proteolytic activation by rhomboid protease RHBDL4.
Shibuya K, Ebihara K, Ebihara C, Sawayama N, Isoda M, Yamamuro D, Takahashi M, Nagashima S, Ishibashi S
The Journal of biological chemistry 2022 Jun;298(6):101936
The Journal of biological chemistry 2022 Jun;298(6):101936
Sigma-1 receptor attenuates osteoclastogenesis by promoting ER-associated degradation of SERCA2.
Wei X, Zheng Z, Feng Z, Zheng L, Tao S, Zheng B, Huang B, Zhang X, Liu J, Chen Y, Zong W, Shan Z, Fan S, Chen J, Zhao F
EMBO molecular medicine 2022 Jul 7;14(7):e15373
EMBO molecular medicine 2022 Jul 7;14(7):e15373
SYVN1-MTR4-MAT2A Signaling Axis Regulates Methionine Metabolism in Glioma Cells.
Wang L, Hu B, Pan K, Chang J, Zhao X, Chen L, Lin H, Wang J, Zhou G, Xu W, Yuan J
Frontiers in cell and developmental biology 2021;9:633259
Frontiers in cell and developmental biology 2021;9:633259
Ginsenoside Rb1 alleviates colitis in mice via activation of endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 signaling pathway.
Dong JY, Xia KJ, Liang W, Liu LL, Yang F, Fang XS, Xiong YJ, Wang L, Zhou ZJ, Li CY, Zhang WD, Wang JY, Chen DP
Acta pharmacologica Sinica 2021 Sep;42(9):1461-1471
Acta pharmacologica Sinica 2021 Sep;42(9):1461-1471
Hydrogen sulphide reduced the accumulation of lipid droplets in cardiac tissues of db/db mice via Hrd1 S-sulfhydration.
Sun Y, Zhang L, Lu B, Wen J, Wang M, Zhang S, Li Q, Shu F, Lu F, Liu N, Peng S, Zhao Y, Dong S, Lu F, Zhang W, Wang Y
Journal of cellular and molecular medicine 2021 Oct;25(19):9154-9167
Journal of cellular and molecular medicine 2021 Oct;25(19):9154-9167
PGRMC1 acts as a size-selective cargo receptor to drive ER-phagic clearance of mutant prohormones.
Chen YJ, Knupp J, Arunagiri A, Haataja L, Arvan P, Tsai B
Nature communications 2021 Oct 13;12(1):5991
Nature communications 2021 Oct 13;12(1):5991
Preservation of endoplasmic reticulum (ER) Ca(2+) stores by deletion of inositol-1,4,5-trisphosphate receptor type 1 promotes ER retrotranslocation, proteostasis, and protein outer segment localization in cyclic nucleotide-gated channel-deficient cone photoreceptors.
Yang F, Ma H, Butler MR, Ding XQ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Jun;35(6):e21579
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Jun;35(6):e21579
CircNR3C2 promotes HRD1-mediated tumor-suppressive effect via sponging miR-513a-3p in triple-negative breast cancer.
Fan Y, Wang J, Jin W, Sun Y, Xu Y, Wang Y, Liang X, Su D
Molecular cancer 2021 Feb 2;20(1):25
Molecular cancer 2021 Feb 2;20(1):25
THADA drives Golgi residency and upregulation of PD-L1 in cancer cells and provides promising target for immunotherapy.
Li C, Chi H, Deng S, Wang H, Yao H, Wang Y, Chen D, Guo X, Fang JY, He F, Xu J
Journal for immunotherapy of cancer 2021 Aug;9(8)
Journal for immunotherapy of cancer 2021 Aug;9(8)
SEL1L degradation intermediates stimulate cytosolic aggregation of polyglutamine-expanded protein.
Hattori T, Hanafusa K, Wada I, Hosokawa N
The FEBS journal 2021 Aug;288(15):4637-4654
The FEBS journal 2021 Aug;288(15):4637-4654
STING regulates BCR signaling in normal and malignant B cells.
Tang CA, Lee AC, Chang S, Xu Q, Shao A, Lo Y, Spalek WT, Pinilla-Ibarz JA, Del Valle JR, Hu CA
Cellular & molecular immunology 2021 Apr;18(4):1016-1031
Cellular & molecular immunology 2021 Apr;18(4):1016-1031
Endoplasmic reticulum-associated degradation is required for nephrin maturation and kidney glomerular filtration function.
Yoshida S, Wei X, Zhang G, O'Connor CL, Torres M, Zhou Z, Lin L, Menon R, Xu X, Zheng W, Xiong Y, Otto E, Tang CA, Hua R, Verma R, Mori H, Zhang Y, Hu CA, Liu M, Garg P, Hodgin JB, Sun S, Bitzer M, Qi L
The Journal of clinical investigation 2021 Apr 1;131(7)
The Journal of clinical investigation 2021 Apr 1;131(7)
ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia.
Ran J, Liu M, Feng J, Li H, Ma H, Song T, Cao Y, Zhou P, Wu Y, Yang Y, Yang Y, Yu F, Guo H, Zhang L, Xie S, Li D, Gao J, Zhang X, Zhu X, Zhou J
Developmental cell 2020 May 4;53(3):287-299.e5
Developmental cell 2020 May 4;53(3):287-299.e5
Reticulon protects the integrity of the ER membrane during ER escape of large macromolecular protein complexes.
Chen YJ, Williams JM, Arvan P, Tsai B
The Journal of cell biology 2020 Feb 3;219(2)
The Journal of cell biology 2020 Feb 3;219(2)
Cross-talks of glycosylphosphatidylinositol biosynthesis with glycosphingolipid biosynthesis and ER-associated degradation.
Wang Y, Maeda Y, Liu YS, Takada Y, Ninomiya A, Hirata T, Fujita M, Murakami Y, Kinoshita T
Nature communications 2020 Feb 13;11(1):860
Nature communications 2020 Feb 13;11(1):860
Exogenous H(2)S Induces Hrd1 S-sulfhydration and Prevents CD36 Translocation via VAMP3 Ubiquitylation in Diabetic Hearts.
Yu M, Du H, Wang B, Chen J, Lu F, Peng S, Sun Y, Liu N, Sun X, Shiyun D, Zhao Y, Wang Y, Zhao D, Lu F, Zhang W
Aging and disease 2020 Apr;11(2):286-300
Aging and disease 2020 Apr;11(2):286-300
Cells Deploy a Two-Pronged Strategy to Rectify Misfolded Proinsulin Aggregates.
Cunningham CN, Williams JM, Knupp J, Arunagiri A, Arvan P, Tsai B
Molecular cell 2019 Aug 8;75(3):442-456.e4
Molecular cell 2019 Aug 8;75(3):442-456.e4
Redundant and Antagonistic Roles of XTP3B and OS9 in Decoding Glycan and Non-glycan Degrons in ER-Associated Degradation.
van der Goot AT, Pearce MMP, Leto DE, Shaler TA, Kopito RR
Molecular cell 2018 May 3;70(3):516-530.e6
Molecular cell 2018 May 3;70(3):516-530.e6
The ubiquitin-proteasome system functionally links neuronal Tomosyn-1 to dendritic morphology.
Saldate JJ, Shiau J, Cazares VA, Stuenkel EL
The Journal of biological chemistry 2018 Feb 16;293(7):2232-2246
The Journal of biological chemistry 2018 Feb 16;293(7):2232-2246
AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity.
Luo H, Jiang M, Lian G, Liu Q, Shi M, Li TY, Song L, Ye J, He Y, Yao L, Zhang C, Lin ZZ, Zhang CS, Zhao TJ, Jia WP, Li P, Lin SY, Lin SC
Cell metabolism 2018 Apr 3;27(4):843-853.e6
Cell metabolism 2018 Apr 3;27(4):843-853.e6
Endoplasmic Reticulum Stress Induces HRD1 to Protect Alveolar Type II Epithelial Cells from Apoptosis Induced by Cigarette Smoke Extract.
Tan SX, Jiang DX, Hu RC, Dai AG, Gan GX, Fu DY, Kong CC, Chen YR, Wang LL, Li J
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(4):1337-1345
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(4):1337-1345
Characterization of protein complexes of the endoplasmic reticulum-associated degradation E3 ubiquitin ligase Hrd1.
Hwang J, Walczak CP, Shaler TA, Olzmann JA, Zhang L, Elias JE, Kopito RR
The Journal of biological chemistry 2017 Jun 2;292(22):9104-9116
The Journal of biological chemistry 2017 Jun 2;292(22):9104-9116
PDI reductase acts on Akita mutant proinsulin to initiate retrotranslocation along the Hrd1/Sel1L-p97 axis.
He K, Cunningham CN, Manickam N, Liu M, Arvan P, Tsai B
Molecular biology of the cell 2015 Oct 1;26(19):3413-23
Molecular biology of the cell 2015 Oct 1;26(19):3413-23
A cytosolic chaperone complexes with dynamic membrane J-proteins and mobilizes a nonenveloped virus out of the endoplasmic reticulum.
Walczak CP, Ravindran MS, Inoue T, Tsai B
PLoS pathogens 2014 Mar;10(3):e1004007
PLoS pathogens 2014 Mar;10(3):e1004007
A deubiquitinase negatively regulates retro-translocation of nonubiquitinated substrates.
Bernardi KM, Williams JM, Inoue T, Schultz A, Tsai B
Molecular biology of the cell 2013 Nov;24(22):3545-56
Molecular biology of the cell 2013 Nov;24(22):3545-56
The ERdj5-Sel1L complex facilitates cholera toxin retrotranslocation.
Williams JM, Inoue T, Banks L, Tsai B
Molecular biology of the cell 2013 Mar;24(6):785-95
Molecular biology of the cell 2013 Mar;24(6):785-95
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 13473-1-AP(HRD1 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SYVN1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SYVN1. This antibody recognizes human,mouse,rat antigen. The SYVN1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
