Antibody data
- Antibody Data
- Antigen structure
- References [18]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 13473-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13473-1-AP, RRID:AB_2287023
- Product name
- HRD1/SYVN1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated HRD1/SYVN1 antibody (Cat. #13473-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references SYVN1-MTR4-MAT2A Signaling Axis Regulates Methionine Metabolism in Glioma Cells.
Ginsenoside Rb1 alleviates colitis in mice via activation of endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 signaling pathway.
CircNR3C2 promotes HRD1-mediated tumor-suppressive effect via sponging miR-513a-3p in triple-negative breast cancer.
SEL1L degradation intermediates stimulate cytosolic aggregation of polyglutamine-expanded protein.
STING regulates BCR signaling in normal and malignant B cells.
ASK1-Mediated Phosphorylation Blocks HDAC6Â Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia.
Cross-talks of glycosylphosphatidylinositol biosynthesis with glycosphingolipid biosynthesis and ER-associated degradation.
Exogenous H2S Induces Hrd1 S-sulfhydration and Prevents CD36 Translocation via VAMP3 Ubiquitylation in Diabetic Hearts.
Cells Deploy a Two-Pronged Strategy to Rectify Misfolded Proinsulin Aggregates.
Redundant and Antagonistic Roles of XTP3B and OS9 in Decoding Glycan and Non-glycan Degrons in ER-Associated Degradation.
The ubiquitin-proteasome system functionally links neuronal Tomosyn-1 to dendritic morphology.
AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity.
Endoplasmic Reticulum Stress Induces HRD1 to Protect Alveolar Type II Epithelial Cells from Apoptosis Induced by Cigarette Smoke Extract.
Characterization of protein complexes of the endoplasmic reticulum-associated degradation E3 ubiquitin ligase Hrd1.
PDI reductase acts on Akita mutant proinsulin to initiate retrotranslocation along the Hrd1/Sel1L-p97 axis.
A cytosolic chaperone complexes with dynamic membrane J-proteins and mobilizes a nonenveloped virus out of the endoplasmic reticulum.
A deubiquitinase negatively regulates retro-translocation of nonubiquitinated substrates.
The ERdj5-Sel1L complex facilitates cholera toxin retrotranslocation.
Wang L, Hu B, Pan K, Chang J, Zhao X, Chen L, Lin H, Wang J, Zhou G, Xu W, Yuan J
Frontiers in cell and developmental biology 2021;9:633259
Frontiers in cell and developmental biology 2021;9:633259
Ginsenoside Rb1 alleviates colitis in mice via activation of endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 signaling pathway.
Dong JY, Xia KJ, Liang W, Liu LL, Yang F, Fang XS, Xiong YJ, Wang L, Zhou ZJ, Li CY, Zhang WD, Wang JY, Chen DP
Acta pharmacologica Sinica 2021 Sep;42(9):1461-1471
Acta pharmacologica Sinica 2021 Sep;42(9):1461-1471
CircNR3C2 promotes HRD1-mediated tumor-suppressive effect via sponging miR-513a-3p in triple-negative breast cancer.
Fan Y, Wang J, Jin W, Sun Y, Xu Y, Wang Y, Liang X, Su D
Molecular cancer 2021 Feb 2;20(1):25
Molecular cancer 2021 Feb 2;20(1):25
SEL1L degradation intermediates stimulate cytosolic aggregation of polyglutamine-expanded protein.
Hattori T, Hanafusa K, Wada I, Hosokawa N
The FEBS journal 2021 Aug;288(15):4637-4654
The FEBS journal 2021 Aug;288(15):4637-4654
STING regulates BCR signaling in normal and malignant B cells.
Tang CA, Lee AC, Chang S, Xu Q, Shao A, Lo Y, Spalek WT, Pinilla-Ibarz JA, Del Valle JR, Hu CA
Cellular & molecular immunology 2021 Apr;18(4):1016-1031
Cellular & molecular immunology 2021 Apr;18(4):1016-1031
ASK1-Mediated Phosphorylation Blocks HDAC6Â Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia.
Ran J, Liu M, Feng J, Li H, Ma H, Song T, Cao Y, Zhou P, Wu Y, Yang Y, Yang Y, Yu F, Guo H, Zhang L, Xie S, Li D, Gao J, Zhang X, Zhu X, Zhou J
Developmental cell 2020 May 4;53(3):287-299.e5
Developmental cell 2020 May 4;53(3):287-299.e5
Cross-talks of glycosylphosphatidylinositol biosynthesis with glycosphingolipid biosynthesis and ER-associated degradation.
Wang Y, Maeda Y, Liu YS, Takada Y, Ninomiya A, Hirata T, Fujita M, Murakami Y, Kinoshita T
Nature communications 2020 Feb 13;11(1):860
Nature communications 2020 Feb 13;11(1):860
Exogenous H2S Induces Hrd1 S-sulfhydration and Prevents CD36 Translocation via VAMP3 Ubiquitylation in Diabetic Hearts.
Yu M, Du H, Wang B, Chen J, Lu F, Peng S, Sun Y, Liu N, Sun X, Shiyun D, Zhao Y, Wang Y, Zhao D, Lu F, Zhang W
Aging and disease 2020 Apr;11(2):286-300
Aging and disease 2020 Apr;11(2):286-300
Cells Deploy a Two-Pronged Strategy to Rectify Misfolded Proinsulin Aggregates.
Cunningham CN, Williams JM, Knupp J, Arunagiri A, Arvan P, Tsai B
Molecular cell 2019 Aug 8;75(3):442-456.e4
Molecular cell 2019 Aug 8;75(3):442-456.e4
Redundant and Antagonistic Roles of XTP3B and OS9 in Decoding Glycan and Non-glycan Degrons in ER-Associated Degradation.
van der Goot AT, Pearce MMP, Leto DE, Shaler TA, Kopito RR
Molecular cell 2018 May 3;70(3):516-530.e6
Molecular cell 2018 May 3;70(3):516-530.e6
The ubiquitin-proteasome system functionally links neuronal Tomosyn-1 to dendritic morphology.
Saldate JJ, Shiau J, Cazares VA, Stuenkel EL
The Journal of biological chemistry 2018 Feb 16;293(7):2232-2246
The Journal of biological chemistry 2018 Feb 16;293(7):2232-2246
AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity.
Luo H, Jiang M, Lian G, Liu Q, Shi M, Li TY, Song L, Ye J, He Y, Yao L, Zhang C, Lin ZZ, Zhang CS, Zhao TJ, Jia WP, Li P, Lin SY, Lin SC
Cell metabolism 2018 Apr 3;27(4):843-853.e6
Cell metabolism 2018 Apr 3;27(4):843-853.e6
Endoplasmic Reticulum Stress Induces HRD1 to Protect Alveolar Type II Epithelial Cells from Apoptosis Induced by Cigarette Smoke Extract.
Tan SX, Jiang DX, Hu RC, Dai AG, Gan GX, Fu DY, Kong CC, Chen YR, Wang LL, Li J
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(4):1337-1345
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(4):1337-1345
Characterization of protein complexes of the endoplasmic reticulum-associated degradation E3 ubiquitin ligase Hrd1.
Hwang J, Walczak CP, Shaler TA, Olzmann JA, Zhang L, Elias JE, Kopito RR
The Journal of biological chemistry 2017 Jun 2;292(22):9104-9116
The Journal of biological chemistry 2017 Jun 2;292(22):9104-9116
PDI reductase acts on Akita mutant proinsulin to initiate retrotranslocation along the Hrd1/Sel1L-p97 axis.
He K, Cunningham CN, Manickam N, Liu M, Arvan P, Tsai B
Molecular biology of the cell 2015 Oct 1;26(19):3413-23
Molecular biology of the cell 2015 Oct 1;26(19):3413-23
A cytosolic chaperone complexes with dynamic membrane J-proteins and mobilizes a nonenveloped virus out of the endoplasmic reticulum.
Walczak CP, Ravindran MS, Inoue T, Tsai B
PLoS pathogens 2014 Mar;10(3):e1004007
PLoS pathogens 2014 Mar;10(3):e1004007
A deubiquitinase negatively regulates retro-translocation of nonubiquitinated substrates.
Bernardi KM, Williams JM, Inoue T, Schultz A, Tsai B
Molecular biology of the cell 2013 Nov;24(22):3545-56
Molecular biology of the cell 2013 Nov;24(22):3545-56
The ERdj5-Sel1L complex facilitates cholera toxin retrotranslocation.
Williams JM, Inoue T, Banks L, Tsai B
Molecular biology of the cell 2013 Mar;24(6):785-95
Molecular biology of the cell 2013 Mar;24(6):785-95
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 13473-1-AP(HRD1 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SYVN1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SYVN1. This antibody recognizes human,mouse,rat antigen. The SYVN1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.