Antibody data
- Antibody Data
- Antigen structure
- References [11]
- Comments [0]
- Validations
- Western blot [3]
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- Product number
- ABIN2837882 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (AA 586-617), (C-Term) antibody
- Antibody type
- Polyclonal
- Description
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Epitope
- AA 586-617, C-Term
- Antibody clone number
- RB4822
- Vial size
- 80 μL
- Storage
- Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots.
- Handling
- Avoid freeze-thaw cycles.
Submitted references Acute ER stress regulates amyloid precursor protein processing through ubiquitin-dependent degradation.
Vacuolar-type H+-ATPase V1A subunit is a molecular partner of Wolfram syndrome 1 (WFS1) protein, which regulates its expression and stability.
Deglycosylation-dependent fluorescent proteins provide unique tools for the study of ER-associated degradation.
Cyclosporin A induces the unfolded protein response in keratinocytes.
Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
Correlation between decrease in protein levels of ubiquitin ligase HRD1 and amyloid-beta production.
Loss of HRD1-mediated protein degradation causes amyloid precursor protein accumulation and amyloid-beta generation.
The unfolded protein response is activated in differentiating epidermal keratinocytes.
An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid beta-protein.
WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells.
Overexpression of synoviolin in peripheral blood and synoviocytes from rheumatoid arthritis patients and continued elevation in nonresponders to infliximab treatment.
Jung ES, Hong H, Kim C, Mook-Jung I
Scientific reports 2015 Mar 5;5:8805
Scientific reports 2015 Mar 5;5:8805
Vacuolar-type H+-ATPase V1A subunit is a molecular partner of Wolfram syndrome 1 (WFS1) protein, which regulates its expression and stability.
Gharanei S, Zatyka M, Astuti D, Fenton J, Sik A, Nagy Z, Barrett TG
Human molecular genetics 2013 Jan 15;22(2):203-17
Human molecular genetics 2013 Jan 15;22(2):203-17
Deglycosylation-dependent fluorescent proteins provide unique tools for the study of ER-associated degradation.
Grotzke JE, Lu Q, Cresswell P
Proceedings of the National Academy of Sciences of the United States of America 2013 Feb 26;110(9):3393-8
Proceedings of the National Academy of Sciences of the United States of America 2013 Feb 26;110(9):3393-8
Cyclosporin A induces the unfolded protein response in keratinocytes.
Hibino M, Sugiura K, Muro Y, Shimoyama Y, Tomita Y
Archives of dermatological research 2011 Sep;303(7):481-9
Archives of dermatological research 2011 Sep;303(7):481-9
Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR
The Journal of biological chemistry 2011 Dec 2;286(48):41530-8
The Journal of biological chemistry 2011 Dec 2;286(48):41530-8
Correlation between decrease in protein levels of ubiquitin ligase HRD1 and amyloid-beta production.
Saito R, Kaneko M, Okuma Y, Nomura Y
Journal of pharmacological sciences 2010;113(3):285-8
Journal of pharmacological sciences 2010;113(3):285-8
Loss of HRD1-mediated protein degradation causes amyloid precursor protein accumulation and amyloid-beta generation.
Kaneko M, Koike H, Saito R, Kitamura Y, Okuma Y, Nomura Y
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Mar 17;30(11):3924-32
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Mar 17;30(11):3924-32
The unfolded protein response is activated in differentiating epidermal keratinocytes.
Sugiura K, Muro Y, Futamura K, Matsumoto K, Hashimoto N, Nishizawa Y, Nagasaka T, Saito H, Tomita Y, Usukura J
The Journal of investigative dermatology 2009 Sep;129(9):2126-35
The Journal of investigative dermatology 2009 Sep;129(9):2126-35
An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid beta-protein.
Maeda T, Marutani T, Zou K, Araki W, Tanabe C, Yagishita N, Yamano Y, Amano T, Michikawa M, Nakajima T, Komano H
The FEBS journal 2009 Oct;276(20):5832-40
The FEBS journal 2009 Oct;276(20):5832-40
WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells.
Yamada T, Ishihara H, Tamura A, Takahashi R, Yamaguchi S, Takei D, Tokita A, Satake C, Tashiro F, Katagiri H, Aburatani H, Miyazaki J, Oka Y
Human molecular genetics 2006 May 15;15(10):1600-9
Human molecular genetics 2006 May 15;15(10):1600-9
Overexpression of synoviolin in peripheral blood and synoviocytes from rheumatoid arthritis patients and continued elevation in nonresponders to infliximab treatment.
Toh ML, Marotte H, Blond JL, Jhumka U, Eljaafari A, Mougin B, Miossec P
Arthritis and rheumatism 2006 Jul;54(7):2109-18
Arthritis and rheumatism 2006 Jul;54(7):2109-18
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- Experimental details
- WB
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB