Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- BS60053 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- COASY polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide corresponding to residues in Human COASY.
- Description
- COASY (coenzyme A synthase), also known as NBP (nucleotide binding protein), DPCK (dephospho-coenzyme A kinase), PPAT (pantetheine-phosphate adenylyltransferase), UKR1 or pOV-2, is a bifunctional enzyme involved in the biosynthesis of coenzyme A (CoA). COASY exhibits both Ppat activity and DPCK activity, catalyzing steps four and five, respectively, of the CoA biosynthetic pathway. Functioning as a widely expressed monomer and induced by phospholipids, COASY localizes to the outer mitochondrial membrane and facilitates the conversion of 4'-phosphopantetheine to dephospho-CoA and the subsequent generation of CoA. CoA is an important molecule in the cell, participating in carbohydrate, amino acid and fatty acid metabolism. It is the predominant acetyl and acyl group carrier and is used as a substrate by approximately 4% of all cellular enzymes. Due to alternative splicing events, an additional isoform of COASY, namely COASY b, is expressed in brain and contains an extra 29 amino acids at the N-terminus.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- Western blot (WB) analysis of COASY pAb at 1:500 dilutionLane1:HEK293T whole cell lysateLane2:Raw264.7 whole cell lysateLane3:PC12 whole cell lysate