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- Antibody Data
- Antigen structure
- References [32]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 10978-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10978-1-AP, RRID:AB_2279863
- Product name
- HSD17B2 antibody
- Antibody type
- Polyclonal
- Description
- HSD17B2 antibody (Cat. #10978-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Oyster-derived dipeptides RI, IR, and VR promote testosterone synthesis by reducing oxidative stress in TM3 cells.
Post-menopausal ovarian fibroma associated with steroid hormone synthesis: A case report.
A long non-coding RNA as a direct vitamin D target transcribed from the antisense strand of the human HSD17B2 locus.
Cytosine-phosphate-guanine oligodeoxynucleotides regulate the cell cycle, apoptosis, and steroidogenesis of mouse ovarian granulosa cells by targeting inhibin alpha (1 ~ 32) fragments.
Hypoxia-Reoxygenation Couples 3βHSD1 Enzyme and Cofactor Upregulation to Facilitate Androgen Biosynthesis and Hormone Therapy Resistance in Prostate Cancer.
Chronic exposure to polystyrene microplastics induced male reproductive toxicity and decreased testosterone levels via the LH-mediated LHR/cAMP/PKA/StAR pathway.
Cypermethrin triggers YY1-mediated testosterone biosynthesis suppression.
17β-Hydroxysteroid dehydrogenase 1:2 and breast cancer recurrence: a Danish population-based study.
Altered expression of 17‑β‑hydroxysteroid dehydrogenase type 2 and its prognostic significance in non‑small cell lung cancer.
Elevated maternal androgen is associated with dysfunctional placenta and lipid disorder in newborns of mothers with polycystic ovary syndrome.
Steroidogenesis in ovarian-like mesenchymal stroma of hepatic and pancreatic mucinous cystic neoplasms.
In breast cancer subtypes steroid sulfatase (STS) is associated with less aggressive tumour characteristics.
Aromatase in normal and diseased liver.
Expression of steroidogenic enzymes and metabolism of steroids in COS-7 cells known as non-steroidogenic cells.
17β-Hydroxysteroid Dehydrogenase Type 2 Expression Is Induced by Androgen Signaling in Endometrial Cancer.
The presence and impact of estrogen metabolism on the biology of triple-negative breast cancer.
Effects of cytokines derived from cancer-associated fibroblasts on androgen synthetic enzymes in estrogen receptor-negative breast carcinoma.
Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques.
Intratumoral estrogen production and actions in luminal A type invasive lobular and ductal carcinomas.
Expression of steroidogenic enzymes in human sebaceous glands.
Intratumoral androgen metabolism and actions in invasive lobular carcinoma of the breast.
Intratumoral localization and activity of 17β-hydroxysteroid dehydrogenase type 1 in non-small cell lung cancer: a potent prognostic factor.
Differential expression of steroidogenic enzymes according to endometriosis type.
The role of estrogen-metabolizing enzymes and estrogen receptors in human epidermis.
Immunolocalization of estrogen-producing and metabolizing enzymes in benign breast disease: comparison with normal breast and breast carcinoma.
Increased intratumoral androgens in human breast carcinoma following aromatase inhibitor exemestane treatment.
MUC1 as a discriminator between endometrium from fertile and infertile patients with PCOS and endometriosis.
Differential gene expression in normal esophagus and Barrett's esophagus.
Sex steroid-dependent and -independent action of hydroxysteroid (17beta) Dehydrogenase 2: evidence from transgenic female mice.
Epithelial cells are the major site of hydroxysteroid (17beta) dehydrogenase 2 and androgen receptor expression in fetal mouse lungs during the period overlapping the surge of surfactant.
Steroidogenic enzyme and key decidualization marker dysregulation in endometrial stromal cells from women with versus without endometriosis.
Quantitative proteome analysis of HCC cell lines with different metastatic potentials by SILAC.
Yan Y, Li M, Wei Y, Jia F, Zheng Y, Tao G, Xiong F
Food science & nutrition 2023 Oct;11(10):6470-6482
Food science & nutrition 2023 Oct;11(10):6470-6482
Post-menopausal ovarian fibroma associated with steroid hormone synthesis: A case report.
Sato N, Itakura Y, Yoshida Y, Akahira J, Fujishima F, Nakamura Y
Taiwanese journal of obstetrics & gynecology 2023 Jul;62(4):566-570
Taiwanese journal of obstetrics & gynecology 2023 Jul;62(4):566-570
A long non-coding RNA as a direct vitamin D target transcribed from the antisense strand of the human HSD17B2 locus.
Kanemoto Y, Nishimura K, Hayakawa A, Sawada T, Amano R, Mori J, Kurokawa T, Murakami Y, Kato S
Bioscience reports 2022 May 27;42(5)
Bioscience reports 2022 May 27;42(5)
Cytosine-phosphate-guanine oligodeoxynucleotides regulate the cell cycle, apoptosis, and steroidogenesis of mouse ovarian granulosa cells by targeting inhibin alpha (1 ~ 32) fragments.
Yang M, Feng J, Lan X, Tang Y, Zhang Y, Zhang H, Wang S
In vitro cellular & developmental biology. Animal 2022 Mar;58(3):243-254
In vitro cellular & developmental biology. Animal 2022 Mar;58(3):243-254
Hypoxia-Reoxygenation Couples 3βHSD1 Enzyme and Cofactor Upregulation to Facilitate Androgen Biosynthesis and Hormone Therapy Resistance in Prostate Cancer.
Qin L, Chung YM, Berk M, Naelitz B, Zhu Z, Klein E, Chakraborty AA, Sharifi N
Cancer research 2022 Jul 5;82(13):2417-2430
Cancer research 2022 Jul 5;82(13):2417-2430
Chronic exposure to polystyrene microplastics induced male reproductive toxicity and decreased testosterone levels via the LH-mediated LHR/cAMP/PKA/StAR pathway.
Jin H, Yan M, Pan C, Liu Z, Sha X, Jiang C, Li L, Pan M, Li D, Han X, Ding J
Particle and fibre toxicology 2022 Feb 17;19(1):13
Particle and fibre toxicology 2022 Feb 17;19(1):13
Cypermethrin triggers YY1-mediated testosterone biosynthesis suppression.
Liu C, Qu J, Wu M, Huang X, Li L
Ecotoxicology and environmental safety 2021 Dec 1;225:112792
Ecotoxicology and environmental safety 2021 Dec 1;225:112792
17β-Hydroxysteroid dehydrogenase 1:2 and breast cancer recurrence: a Danish population-based study.
Collin LJ, Ulrichsen SP, Ahern TP, Goodman M, McCullough LE, Waller LA, Bang Christensen K, Damkier P, Hamilton-Dutoit S, Lauridsen KL, Yacoub R, Christiansen PM, Ejlertsen B, Sørensen HT, Cronin-Fenton DP, Lash TL
Acta oncologica (Stockholm, Sweden) 2020 Mar;59(3):329-333
Acta oncologica (Stockholm, Sweden) 2020 Mar;59(3):329-333
Altered expression of 17‑β‑hydroxysteroid dehydrogenase type 2 and its prognostic significance in non‑small cell lung cancer.
Drzewiecka H, Jarmołowska-Jurczyszyn D, Kluk A, Gałęcki B, Dyszkiewicz W, Jagodziński PP
International journal of oncology 2020 Jun;56(6):1352-1372
International journal of oncology 2020 Jun;56(6):1352-1372
Elevated maternal androgen is associated with dysfunctional placenta and lipid disorder in newborns of mothers with polycystic ovary syndrome.
Sun M, Sun B, Qiao S, Feng X, Li Y, Zhang S, Lin Y, Hou L
Fertility and sterility 2020 Jun;113(6):1275-1285.e2
Fertility and sterility 2020 Jun;113(6):1275-1285.e2
Steroidogenesis in ovarian-like mesenchymal stroma of hepatic and pancreatic mucinous cystic neoplasms.
Kumata H, Murakami K, Ishida K, Miyagi S, Arakawa A, Inayama Y, Kinowaki K, Ochiai A, Kojima M, Higashi M, Moritani S, Kuwahara K, Nakatani Y, Kajiura D, Tamura G, Kijima H, Yamakawa M, Shiraishi T, Inadome Y, Murakami K, Suzuki H, Sawai T, Unno M, Kamei T, Sasano H
Hepatology research : the official journal of the Japan Society of Hepatology 2018 Nov;48(12):989-999
Hepatology research : the official journal of the Japan Society of Hepatology 2018 Nov;48(12):989-999
In breast cancer subtypes steroid sulfatase (STS) is associated with less aggressive tumour characteristics.
McNamara KM, Guestini F, Sauer T, Touma J, Bukholm IR, Lindstrøm JC, Sasano H, Geisler J
British journal of cancer 2018 May;118(9):1208-1216
British journal of cancer 2018 May;118(9):1208-1216
Aromatase in normal and diseased liver.
Murakami K, Hata S, Miki Y, Sasano H
Hormone molecular biology and clinical investigation 2018 Feb 28;41(1)
Hormone molecular biology and clinical investigation 2018 Feb 28;41(1)
Expression of steroidogenic enzymes and metabolism of steroids in COS-7 cells known as non-steroidogenic cells.
Nozaki M, Haraguchi S, Miyazaki T, Shigeta D, Kano N, Lei XF, Kim-Kaneyama JR, Minakata H, Miyazaki A, Tsutsui K
Scientific reports 2018 Feb 1;8(1):2167
Scientific reports 2018 Feb 1;8(1):2167
17β-Hydroxysteroid Dehydrogenase Type 2 Expression Is Induced by Androgen Signaling in Endometrial Cancer.
Hashimoto C, Miki Y, Tanaka S, Takagi K, Fue M, Doe Z, Li B, Yaegashi N, Suzuki T, Ito K
International journal of molecular sciences 2018 Apr 10;19(4)
International journal of molecular sciences 2018 Apr 10;19(4)
The presence and impact of estrogen metabolism on the biology of triple-negative breast cancer.
McNamara KM, Oguro S, Omata F, Kikuchi K, Guestini F, Suzuki K, Yang Y, Abe E, Hirakawa H, Brown KA, Takanori I, Ohuchi N, Sasano H
Breast cancer research and treatment 2017 Jan;161(2):213-227
Breast cancer research and treatment 2017 Jan;161(2):213-227
Effects of cytokines derived from cancer-associated fibroblasts on androgen synthetic enzymes in estrogen receptor-negative breast carcinoma.
Kikuchi K, McNamara KM, Miki Y, Moon JY, Choi MH, Omata F, Sakurai M, Onodera Y, Rai Y, Ohi Y, Sagara Y, Miyashita M, Ishida T, Ohuchi N, Sasano H
Breast cancer research and treatment 2017 Dec;166(3):709-723
Breast cancer research and treatment 2017 Dec;166(3):709-723
Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques.
Dewi FN, Wood CE, Willson CJ, Register TC, Lees CJ, Howard TD, Huang Z, Murphy SK, Tooze JA, Chou JW, Miller LD, Cline JM
Cancer prevention research (Philadelphia, Pa.) 2016 May;9(5):385-95
Cancer prevention research (Philadelphia, Pa.) 2016 May;9(5):385-95
Intratumoral estrogen production and actions in luminal A type invasive lobular and ductal carcinomas.
Takagi M, Miki Y, Miyashita M, Hata S, Yoda T, Hirakawa H, Sagara Y, Rai Y, Ohi Y, Tamaki K, Ishida T, Suzuki T, Ouchi N, Sasano H
Breast cancer research and treatment 2016 Feb;156(1):45-55
Breast cancer research and treatment 2016 Feb;156(1):45-55
Expression of steroidogenic enzymes in human sebaceous glands.
Inoue T, Miki Y, Kakuo S, Hachiya A, Kitahara T, Aiba S, Zouboulis CC, Sasano H
The Journal of endocrinology 2014 Sep;222(3):301-12
The Journal of endocrinology 2014 Sep;222(3):301-12
Intratumoral androgen metabolism and actions in invasive lobular carcinoma of the breast.
Yoda T, McNamara KM, Miki Y, Takagi M, Rai Y, Ohi Y, Sagara Y, Tamaki K, Hirakawa H, Ishida T, Suzuki T, Ohuchi N, Sasano H
Cancer science 2014 Nov;105(11):1503-9
Cancer science 2014 Nov;105(11):1503-9
Intratumoral localization and activity of 17β-hydroxysteroid dehydrogenase type 1 in non-small cell lung cancer: a potent prognostic factor.
Verma MK, Miki Y, Abe K, Suzuki T, Niikawa H, Suzuki S, Kondo T, Sasano H
Journal of translational medicine 2013 Jul 9;11:167
Journal of translational medicine 2013 Jul 9;11:167
Differential expression of steroidogenic enzymes according to endometriosis type.
Colette S, Defrère S, Van Kerk O, Van Langendonckt A, Dolmans MM, Donnez J
Fertility and sterility 2013 Dec;100(6):1642-9
Fertility and sterility 2013 Dec;100(6):1642-9
The role of estrogen-metabolizing enzymes and estrogen receptors in human epidermis.
Inoue T, Miki Y, Abe K, Hatori M, Hosaka M, Kariya Y, Kakuo S, Fujimura T, Hachiya A, Aiba S, Sasano H
Molecular and cellular endocrinology 2011 Sep 15;344(1-2):35-40
Molecular and cellular endocrinology 2011 Sep 15;344(1-2):35-40
Immunolocalization of estrogen-producing and metabolizing enzymes in benign breast disease: comparison with normal breast and breast carcinoma.
Sasaki Y, Miki Y, Hirakawa H, Onodera Y, Takagi K, Akahira J, Honma S, Ishida T, Watanabe M, Sasano H, Suzuki T
Cancer science 2010 Oct;101(10):2286-92
Cancer science 2010 Oct;101(10):2286-92
Increased intratumoral androgens in human breast carcinoma following aromatase inhibitor exemestane treatment.
Takagi K, Miki Y, Nagasaki S, Hirakawa H, Onodera Y, Akahira J, Ishida T, Watanabe M, Kimijima I, Hayashi S, Sasano H, Suzuki T
Endocrine-related cancer 2010 Jun;17(2):415-30
Endocrine-related cancer 2010 Jun;17(2):415-30
MUC1 as a discriminator between endometrium from fertile and infertile patients with PCOS and endometriosis.
Margarit L, Taylor A, Roberts MH, Hopkins L, Davies C, Brenton AG, Conlan RS, Bunkheila A, Joels L, White JO, Gonzalez D
The Journal of clinical endocrinology and metabolism 2010 Dec;95(12):5320-9
The Journal of clinical endocrinology and metabolism 2010 Dec;95(12):5320-9
Differential gene expression in normal esophagus and Barrett's esophagus.
Wang J, Qin R, Ma Y, Wu H, Peters H, Tyska M, Shaheen NJ, Chen X
Journal of gastroenterology 2009;44(9):897-911
Journal of gastroenterology 2009;44(9):897-911
Sex steroid-dependent and -independent action of hydroxysteroid (17beta) Dehydrogenase 2: evidence from transgenic female mice.
Shen Z, Saloniemi T, Rönnblad A, Järvensivu P, Pakarinen P, Poutanen M
Endocrinology 2009 Nov;150(11):4941-9
Endocrinology 2009 Nov;150(11):4941-9
Epithelial cells are the major site of hydroxysteroid (17beta) dehydrogenase 2 and androgen receptor expression in fetal mouse lungs during the period overlapping the surge of surfactant.
Plante J, Simard M, Rantakari P, Côté M, Provost PR, Poutanen M, Tremblay Y
The Journal of steroid biochemistry and molecular biology 2009 Nov;117(4-5):139-45
The Journal of steroid biochemistry and molecular biology 2009 Nov;117(4-5):139-45
Steroidogenic enzyme and key decidualization marker dysregulation in endometrial stromal cells from women with versus without endometriosis.
Aghajanova L, Hamilton A, Kwintkiewicz J, Vo KC, Giudice LC
Biology of reproduction 2009 Jan;80(1):105-14
Biology of reproduction 2009 Jan;80(1):105-14
Quantitative proteome analysis of HCC cell lines with different metastatic potentials by SILAC.
Chen N, Sun W, Deng X, Hao Y, Chen X, Xing B, Jia W, Ma J, Wei H, Zhu Y, Qian X, Jiang Y, He F
Proteomics 2008 Dec;8(23-24):5108-18
Proteomics 2008 Dec;8(23-24):5108-18
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human liver tissue were subjected to SDS PAGE followed by western blot with 10978-1-AP(HSD17B2 antibody) at dilution of 1:400
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HSD17B2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human HSD17B2. This antibody recognizes human antigen. The HSD17B2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
