23865-1-AP

antibody from Proteintech Group

Targeting: USP39 CGI-21, SAD1, SNRNP65

Provider product page for 23865-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [24]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 23865-1-AP - Provider product page
Provider: Proteintech Group
Product name: USP39 antibody
Antibody type: Polyclonal
Description: KD/KO validated USP39 antibody (Cat. #23865-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

USP39 protein structure - 23865-1-AP shown in red.

Submitted references USP39 inhibits MLKL phosphorylation and deubiquitination to suppress necroptosis of nucleus pulposus cells and attenuate intervertebral disc degeneration.

Zhu Z, Lin X, Kong F, Wang Z, Liang Y, Ji C, Chen H, Sun K, Wang C, Xu X, Shi J
Journal of orthopaedic translation 2026 Jan;56:101039

Enhanced packaging of U6 small nuclear RNA and splicing-related proteins into extracellular vesicles during HIV infection.

Huang Y, Abdelgawad A, Gololobova O, Liao Z, Cong X, Batish M, Zheng L, Witwer KW
Science advances 2025 Mar 14;11(11):eadq6557

USP39 phase separates into the nucleolus and drives lung adenocarcinoma progression by promoting GLI1 expression.

Cheng S, Qiu Z, Zhang Z, Li Y, Zhu Y, Zhou Y, Yang Y, Zhang Y, Yang D, Zhang Y, Liu H, Dai Z, Sun SL, Liu S
Cell communication and signaling : CCS 2025 Jan 30;23(1):56

USP39 Depletion Plays Repressive Roles in Laryngeal Squamous Cell Carcinoma Development.

Xie W, Zhang L, Hu X, Zhong Y, Li Z
Cell biology international 2025 Aug;49(8):1003-1014

Polystyrene microspheres could inhibit the ferroptosis of prostate cancer cells via USP39/IGF2BP3/MAPK4 axis.

Lu S, Wu R, Li W, Fu Z, Ding X, Luan Y, Tianbao H, Huang Y
Journal of translational medicine 2025 Aug 11;23(1):891

Adipose stem cell exosomes, stimulated by pro-inflammatory factors, enhance immune evasion in triple-negative breast cancer by modulating the HDAC6/STAT3/PD-L1 pathway through the transporter UCHL1.

Zhu Q, Zhang K, Cao Y, Hu Y
Cancer cell international 2024 Nov 20;24(1):385

Histone lactylation promotes malignant progression by facilitating USP39 expression to target PI3K/AKT/HIF-1α signal pathway in endometrial carcinoma.

Wei S, Zhang J, Zhao R, Shi R, An L, Yu Z, Zhang Q, Zhang J, Yao Y, Li H, Wang H
Cell death discovery 2024 Mar 8;10(1):121

Lactate modulates RNA splicing to promote CTLA-4 expression in tumor-infiltrating regulatory T cells.

Ding R, Yu X, Hu Z, Dong Y, Huang H, Zhang Y, Han Q, Ni ZY, Zhao R, Ye Y, Zou Q
Immunity 2024 Mar 12;57(3):528-540.e6

USP39 regulates pyruvate handling in non-small cell lung cancer.

Becirovic T, Zhang B, Vakifahmetoglu-Norberg H, Kaminskyy VO, Kochetkova E, Norberg E
Cell death discovery 2024 Dec 18;10(1):502

USP39-Mediated Non-Proteolytic Control of ETS2 Suppresses Nuclear Localization and Activity.

Choi Y, Lee Y, Kim JS, Zhang P, Kim J
Biomolecules 2023 Oct 1;13(10)

Lysine 2-hydroxyisobutyrylation of NAT10 promotes cancer metastasis in an ac4C-dependent manner.

Liao L, He Y, Li SJ, Yu XM, Liu ZC, Liang YY, Yang H, Yang J, Zhang GG, Deng CM, Wei X, Zhu YD, Xu TY, Zheng CC, Cheng C, Li A, Li ZG, Liu JB, Li B
Cell research 2023 May;33(5):355-371

USP39 facilitates breast cancer cell proliferation through stabilization of FOXM1.

Zhang Z, Liu W, Bao X, Sun T, Wang J, Li M, Liu C
American journal of cancer research 2022;12(8):3644-3661

DNAAF5 promotes hepatocellular carcinoma malignant progression by recruiting USP39 to improve PFKL protein stability.

Liu Y, Wu Q, Sun T, Huang J, Han G, Han H
Frontiers in oncology 2022;12:1032579

The Deubiquitinase USP39 Promotes Esophageal Squamous Cell Carcinoma Malignancy as a Splicing Factor.

Zhu X, Ma J, Lu M, Liu Z, Sun Y, Chen H
Genes 2022 May 3;13(5)

Ubiquitin-specific peptidase 39 promotes human glioma cells migration and invasion by facilitating ADAM9 mRNA maturation.

Xiao Y, Ma W, Hu W, Di Q, Zhao X, Ma X, Chen X, Sun P, Wu H, Wu Z, Chen W
Molecular oncology 2022 Jan;16(2):388-404

The LINC00623/NAT10 signaling axis promotes pancreatic cancer progression by remodeling ac4C modification of mRNA.

Feng Z, Li K, Qin K, Liang J, Shi M, Ma Y, Zhao S, Liang H, Han D, Shen B, Peng C, Chen H, Jiang L
Journal of hematology & oncology 2022 Aug 17;15(1):112

MiR-1281, a p53-responsive microRNA, impairs the survival of human osteosarcoma cells upon ER stress via targeting USP39.

Jiang J, Ma B, Li X, Jin W, Han C, Wang L, Wang H
American journal of cancer research 2018;8(9):1764-1774

Identification of a 35S U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP) complex intermediate in spliceosome assembly.

Chen Z, Gui B, Zhang Y, Xie G, Li W, Liu S, Xu B, Wu C, He L, Yang J, Yi X, Yang X, Sun L, Liang J, Shang Y
The Journal of biological chemistry 2017 Nov 3;292(44):18113-18128

Knockdown of ubiquitin-specific peptidase 39 inhibited the growth of osteosarcoma cells and induced apoptosis in vitro.

Gan Z, Han K, Lin S, Hu H, Shen Z, Min D
Biological research 2017 Apr 12;50(1):15

Knockdown of USP39 by lentivirus-mediated RNA interference suppresses the growth of oral squamous cell carcinoma.

Li KY, Zhang J, Jiang LC, Zhang B, Xia CP, Xu K, Chen HY, Yang QZ, Liu SW, Zhu H
Cancer biomarkers : section A of Disease markers 2016;16(1):137-144

Ubiquitin-specific protease 39 is overexpressed in human lung cancer and promotes tumor cell proliferation in vitro.

Lin Z, Xiong L, Lin Q
Molecular and cellular biochemistry 2016 Nov;422(1-2):97-107

Lentivirus-mediated inhibition of USP39 suppresses the growth of gastric cancer cells via PARP activation.

Wang X, Yu Q, Huang L, Yu P
Molecular medicine reports 2016 Jul;14(1):301-6

Overexpression of USP39 predicts poor prognosis and promotes tumorigenesis of prostate cancer via promoting EGFR mRNA maturation and transcription elongation.

Huang Y, Pan XW, Li L, Chen L, Liu X, Lu JL, Zhu XM, Huang H, Yang QW, Ye JQ, Gan SS, Wang LH, Hong Y, Xu DF, Cui XG
Oncotarget 2016 Apr 19;7(16):22016-30

Reduced USP39 expression inhibits malignant proliferation of medullary thyroid carcinoma in vitro.

An Y, Yang S, Guo K, Ma B, Wang Y
World journal of surgical oncology 2015 Aug 25;13(1):255

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: K-562 cells were subjected to SDS PAGE followed by western blot with 23865-1-AP(USP39 antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The USP39 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human USP39. This antibody recognizes human antigen. The USP39 antibody has been validated for the following applications: ELISA, WB, IF analysis.
Appendix: 23865-1-AP.pdf

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