12296-1-AP

antibody from Proteintech Group

Targeting: SFXN1 FLJ12876, SLC56A1

Provider product page for 12296-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [17]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 12296-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#12296-1-AP, RRID:AB_2185814
Product name: SFXN1 antibody
Antibody type: Polyclonal
Description: KD/KO validated SFXN1 antibody (Cat. #12296-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SFXN1 protein structure - 12296-1-AP shown in red.

Submitted references AAV9-mediated gene therapy restores liver function in the MEGDHEL mouse model.

Wei T, Lin Y, Ouyang W, Lei Y, Yang X, Chen L, He X, Fang Q, Zheng X, Tong H, Tu B, Zeng J, Lyu J, Du M, Gui S
Biochimica et biophysica acta. Molecular cell research 2025 Oct;1872(7):120014

PLK1-mediated phosphorylation of PHGDH reprograms serine metabolism in advanced prostate cancer.

Rao X, Allison DB, Flight RM, Lin P, He D, Li Z, Zhang Y, Wang R, Li C, Wang J, Wang X, Peng J, Fong KW, Shao Q, Wang C, Ali ES, Moseley HN, Liu X
bioRxiv : the preprint server for biology 2025 May 24;

Sideroflexins enable mitochondrial transport of polar neutral amino acids.

Block S, Chi F, Rosen PC, Pineda SS, Darnell AM, Abbott KL, Pena IA, Heiman M, Yilmaz ÖH, Kory N, Vander Heiden MG
bioRxiv : the preprint server for biology 2025 Jul 2;

α-Linolenic Acid Alleviates Diabetic Cardiomyopathy by Activating AMPK-STAT3 Pathway to Inhibit Ferritinophagy and Enhance SLC7A11-GPX4 Antioxidant Axis.

Zhang Z, Bai X, Du Q, Yang J
Molecules (Basel, Switzerland) 2025 Dec 24;31(1)

FBLN1 regulates ferroptosis in acute respiratory distress syndrome by reducing free ferrous iron by inhibiting the TGF-β/Smad pathway.

Yuan Y, Wang Y, Yan Y, Kim E, Bai J, Zhao Y, Ma Q, Gu W, Song H
PloS one 2024;19(12):e0314750

RNAi screens identify HES4 as a regulator of redox balance supporting pyrimidine synthesis and tumor growth.

He J, Wang A, Zhao Q, Zou Y, Zhang Z, Sha N, Hou G, Zhou B, Yang Y, Chen T, Zhao Y, Jiang Y
Nature structural & molecular biology 2024 Sep;31(9):1413-1425

Downregulation of the (pro)renin receptor alleviates ferroptosis-associated cardiac pathological changes via the NCOA 4-mediated ferritinophagy pathway in diabetic cardiomyopathy.

Zhang X, Dong X, Jie H, Li S, Li H, Su Y, Li L, Kang L, Dong B, Zhang Y
International immunopharmacology 2024 Sep 10;138:112605

SFXN1-mediated immune cell infiltration and tumorigenesis in lung adenocarcinoma: A potential therapeutic target.

Li Y, Yang W, Liu C, Zhou S, Liu X, Zhang T, Wu L, Li X, Zhang J, Chang E
International immunopharmacology 2024 May 10;132:111918

Comprehensive analysis the prognostic and immune characteristics of mitochondrial transport-related gene SFXN1 in lung adenocarcinoma.

Liu W, Du Q, Mei T, Wang J, Huang D, Qin T
BMC cancer 2024 Jan 17;24(1):94

SFXN1 as a potential diagnostic and prognostic biomarker of LUAD is associated with (18)F-FDG metabolic parameters.

Zhang YH, Liu XS, Gao Y, Yuan LL, Huang ZM, Zhang Y, Liu ZY, Yang Y, Liu XY, Ke CB, Pei ZJ
Lung cancer (Amsterdam, Netherlands) 2024 Feb;188:107449

Ferritinophagy activation and sideroflexin1-dependent mitochondrial iron overload contribute to patulin-induced cardiac inflammation and fibrosis.

Sun WC, Wang NN, Li R, Sun XC, Liao JW, Yang G, Liu S
The Science of the total environment 2023 Sep 20;892:164472

Loss of SFXN1 mitigates lipotoxicity and predicts poor outcome in non-viral hepatocellular carcinoma.

Yagi K, Shimada S, Akiyama Y, Hatano M, Asano D, Ishikawa Y, Ueda H, Watanabe S, Akahoshi K, Ono H, Tanabe M, Tanaka S
Scientific reports 2023 Jun 9;13(1):9449

YAP1 alleviates sepsis-induced acute lung injury via inhibiting ferritinophagy-mediated ferroptosis.

Zhang J, Zheng Y, Wang Y, Wang J, Sang A, Song X, Li X
Frontiers in immunology 2022;13:884362

The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism.

Acoba MG, Alpergin ESS, Renuse S, Fernández-Del-Río L, Lu YW, Khalimonchuk O, Clarke CF, Pandey A, Wolfgang MJ, Claypool SM
Cell reports 2021 Mar 16;34(11):108869

Effect of selectively knocking down key metabolic genes in Müller glia on photoreceptor health.

Shen W, Lee SR, Mathai AE, Zhang R, Du J, Yam MX, Pye V, Barnett NL, Rayner CL, Zhu L, Hurley JB, Seth P, Hirabayashi Y, Furuya S, Gillies MC
Glia 2021 Aug;69(8):1966-1986

Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers.

Soula M, Weber RA, Zilka O, Alwaseem H, La K, Yen F, Molina H, Garcia-Bermudez J, Pratt DA, Birsoy K
Nature chemical biology 2020 Dec;16(12):1351-1360

The liver connexin32 interactome is a novel plasma membrane-mitochondrial signaling nexus.

Fowler SL, Akins M, Zhou H, Figeys D, Bennett SA
Journal of proteome research 2013 Jun 7;12(6):2597-610

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human brain tissue were subjected to SDS PAGE followed by western blot with 12296-1-AP(SFXN1 antibody) at dilution of 1:400
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The SFXN1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SFXN1. This antibody recognizes human,mouse,rat antigen. The SFXN1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 12296-1-AP.pdf

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