25349-1-AP

antibody from Proteintech Group

Targeting: SENP1

Provider product page for 25349-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [24]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 25349-1-AP - Provider product page
Provider: Proteintech Group
Product name: SENP1 antibody
Antibody type: Polyclonal
Description: KD/KO validated SENP1 antibody (Cat. #25349-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, IP, WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SENP1 protein structure - 25349-1-AP shown in red.

Submitted references Honghua Xiaoyao tablets ameliorate premenstrual syndrome by modulating HPA axis and restoring ovarian estrogen synthesis to attenuate hippocampal neuroinflammation.

Chen K, Gao S, Cai B, Ma Z, Liu X, Chen W, Lin N, Zhang Y
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120688

SENP1 promotes p27kip1 nuclear export though enhanced SUMOylation in cholangiocarcinoma leading to increased cell proliferation and chemoresistance.

Jiang K, Yang W, Huang J, Tan X, Liu Y, Tu S, Luo J
International journal of molecular medicine 2025 Sep;56(3)

SUMOylation of ZEB1 Modulates PANoptosis in Burn-Induced Early Acute Kidney Injury.

Zhang J, Huang Z, Lin Q, Zhong H, Hu W, Zhang F, Huang J
Journal of cellular and molecular medicine 2025 Oct;29(20):e70865

IDR-driven TOLLIP condensates antagonize the innate antiviral immunity by promoting the deSUMOylation of MAVS.

Hou J, Zheng S, Zhang X, Zhuang M, Zhao X, Deng J, Yang H, Xia X, Gao C, Wang PH, Zheng Y
Cell reports 2025 Mar 25;44(3):115348

SENP3 protects hepatocyte from pyroptosis during acute liver injury through deSUMOylation of HNRNPL.

Xiong X, Zhi Y, Yang N, Zhao W, Wang S, Zhu H, Tang J, Yi J, Sun X, Yang J
iScience 2025 Aug 15;28(8):113067

Sphingosine Kinase 1 Aggravates Liver Fibrosis by Mediating Macrophage Recruitment and Polarization.

Ding X, Zhang X, Cao J, Chen S, Chen Y, Yuan K, Chen B, Yang G, Li S, Yang J, Wang G, Tacke F, Lan T
Cellular and molecular gastroenterology and hepatology 2024;18(6):101406

MBNL2 promotes aging-related cardiac fibrosis via inhibited SUMOylation of Krüppel-like factor4.

Lu J, Zhao Q, Wang L, Li J, Wang H, Lv L, Yuan M, Chen Q, Zhang Z, Luo D, Sheng S, Yuan K, Liu G, Liu M, Shi Y, Guo Y, Dong Z
iScience 2024 Jul 19;27(7):110163

Sentrin-specific protease 1 maintains mitochondrial homeostasis through targeting the deSUMOylation of sirtuin-3 to alleviate oxidative damage induced by hepatic ischemia/reperfusion.

Xia K, Guo J, Yu B, Wang T, Qiu Q, Chen Q, Qiu T, Zhou J, Zheng S
Free radical biology & medicine 2024 Jan;210:378-389

Nicotinamide mononucleotide attenuates airway epithelial barrier dysfunction via inhibiting SIRT3 SUMOylation in asthma.

Liang J, Zhou C, Zhang C, Liang S, Zhou Z, Zhou Z, Wu C, Zhao H, Meng X, Zou F, Yu C, Cai S
International immunopharmacology 2024 Jan 25;127:111328

SENP1 inhibits ferroptosis and promotes head and neck squamous cell carcinoma by regulating ACSL4 protein stability via SUMO1.

Xu X, Mao Y, Feng Z, Dai F, Gu T, Zheng J
Oncology reports 2024 Feb;51(2)

Human ANP32A/B are SUMOylated and utilized by avian influenza virus NS2 protein to overcome species-specific restriction.

Sun L, Guo X, Yu M, Wang XF, Ren H, Wang X
Nature communications 2024 Dec 30;15(1):10805

SENP1 reduces oxidative stress and apoptosis in renal ischaemia-reperfusion injury by deSUMOylation of HIF-1α.

Hui Y, Xia K, Zhong J, Zhang Y, Qiu Q, Chen Z, Wang L, Liu X
Journal of cellular and molecular medicine 2024 Aug;28(16):e70043

Astragaloside IV combined with ligustrazine ameliorates abnormal mitochondrial dynamics via Drp1 SUMO/deSUMOylation in cerebral ischemia-reperfusion injury.

Chen X, Yang T, Zhou Y, Mei Z, Zhang W
CNS neuroscience & therapeutics 2024 Apr;30(4):e14725

The Cajal body marker protein coilin is SUMOylated and possesses SUMO E3 ligase-like activity.

Lett KE, McLaurin DM, Tucker SK, Hebert MD
Frontiers in RNA research 2023;1

miR‑122/SENP1 axis confers stemness and chemoresistance to liver cancer through Wnt/β‑catenin signaling.

Dai J, Hao Y, Chen X, Yu Q, Wang B
Oncology letters 2023 Sep;26(3):390

LncRNA FRMD6-AS1 promotes hepatocellular carcinoma cell migration and stemness by regulating SENP1/HIF-1α axis.

Sun W, Lei X, Lu Q, Wu Q, Ma Q, Huang D, Zhang Y
Pathology, research and practice 2023 Mar;243:154377

Mitochondrial SENP2 regulates the assembly of SDH complex under metabolic stress.

Liu Y, Liu K, Thorne RF, Shi R, Zhang Q, Wu M, Liu L
Cell reports 2023 Feb 28;42(2):112041

Lactate regulates cell cycle by remodelling the anaphase promoting complex.

Liu W, Wang Y, Bozi LHM, Fischer PD, Jedrychowski MP, Xiao H, Wu T, Darabedian N, He X, Mills EL, Burger N, Shin S, Reddy A, Sprenger HG, Tran N, Winther S, Hinshaw SM, Shen J, Seo HS, Song K, Xu AZ, Sebastian L, Zhao JJ, Dhe-Paganon S, Che J, Gygi SP, Arthanari H, Chouchani ET
Nature 2023 Apr;616(7958):790-797

Multiple-Site SUMOylation of FMDV 3C Protease and Its Negative Role in Viral Replication.

Wu X, Hu Y, Sui C, Pan L, Yoo D, Miller LC, Lee C, Cong X, Li J, Du Y, Qi J
Journal of virology 2022 Sep 14;96(17):e0061222

Momordin Ic induces G0/1 phase arrest and apoptosis in colon cancer cells by suppressing SENP1/c-MYC signaling pathway.

Xianjun F, Xirui X, Jie T, Huiwen M, Shaojun Z, Qiaoyun L, Yunxin L, Xuqun S
Journal of pharmacological sciences 2021 Aug;146(4):249-258

SCARF1 promotes M2 polarization of Kupffer cells via calcium-dependent PI3K-AKT-STAT3 signalling to improve liver transplantation.

Xu XS, Feng ZH, Cao D, Wu H, Wang MH, Li JZ, Gong JP
Cell proliferation 2021 Apr;54(4):e13022

Long noncoding RNA MCM3AP-AS1 enhances cell proliferation and metastasis in colorectal cancer by regulating miR-193a-5p/SENP1.

Zhou M, Bian Z, Liu B, Zhang Y, Cao Y, Cui K, Sun S, Li J, Zhang J, Wang X, Li C, Yao S, Yin Y, Fei B, Huang Z
Cancer medicine 2021 Apr;10(7):2470-2481

A fine-tuning mechanism underlying self-control for autophagy: deSUMOylation of BECN1 by SENP3.

Liu K, Guo C, Lao Y, Yang J, Chen F, Zhao Y, Yang Y, Yang J, Yi J
Autophagy 2020 Jun;16(6):975-990

SENP1 Interacts with HIF1α to Regulate Glycolysis of Prostatic Carcinoma Cells.

Wang C, Tao W, Ni S, Chen Q
International journal of biological sciences 2019;15(2):395-403

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 25349-1-AP( SENP1 Antibody) at dilution of 1:1000
Other comments: WB
Appendix: 25349-1-AP.pdf

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemistry of paraffin-embedded human liver tissue slide using 25349-1-AP( SENP1 Antibody) at dilution of 1:50 (under 40x lens)
Other comments: IHC
Appendix: 25349-1-AP.pdf

: Show more