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- Antibody Data
- Antigen structure
- References [84]
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- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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- Product number
- 11776-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11776-1-AP, RRID:AB_2298317
- Product name
- NAMPT/PBEF antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated NAMPT/PBEF antibody (Cat. #11776-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat, zebrafish and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat, Zebrafish
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Glycogen Synthase Kinase 3 β Hepatocyte Deletion Attenuates Ferroptosis and Metabolic Dysfunction-associated Steatohepatitis in Mice.
METTL1-deficient mesenchymal stem cells protect against metabolic-associated fatty liver disease by increasing NAMPT secretion.
SIRT1 mediates brain metabolic and developmental consequences of methionine synthase deficiency in inborn errors of cobalamin metabolism.
Administration of Nicotinamide Mononucleotide Mitigates the HIV Nef-Induced Metabolic and Pathological Changes in the Heart.
Curcumin inhibits colorectal cancer progression by regulating MDH2-mediated glycolysis and NAD(+) metabolism.
Swietenine alleviated cardiomyocyte inflammation in diabetic cardiomyopathy by regulating NAMPT/SIRT1.
Targeting NAD(+) Salvage Suppresses PBMC Inflammation to Improve Cognitive Function in Vascular Cognitive Impairment.
NMN/NAD(+)/SIRT1 axis activates NAMPT to ameliorate H(2)O(2)-triggered the impairment of progesterone synthesis in ovarian granulosa cells.
NAD(+) sensing by PARP7 regulates the C/EBPβ-dependent transcription program during adipogenesis.
Circadian rhythm disruption impairs ovarian follicular development via NAD(+) metabolic reprogramming.
NAMPT improves high-fat diet-induced nonalcoholic fatty liver disease (NAFLD) via the SIRT1-C/EBPβ-STEAP4-NRF2 axis.
Dual Single-Atom Engineered NADH Oxidase-Mimic Boosts In Situ NAD(+) Biotransformation for Targeted Myocardial Ischemia/Reperfusion Protection.
The role of the gut microbiota and the nicotinate/nicotinamide pathway in rotenone-induced neurotoxicity.
NAMPT Impairs Vascular Permeability in Periodontitis by Influencing FASN-mediated Lipogenesis.
The eNAMPT-Integrin α5β1 Axis Mediates Neutrophil-Endothelial Cell Interactions Driving Inflammation in Ulcerative Colitis.
Alisol A ameliorates vascular cognitive impairment via AMPK/NAMPT/SIRT1-mediated regulation of cholesterol and autophagy.
Nicotinamide metabolic dysregulation plays a key role in Benzo[a]pyrene-induced adverse birth outcomes: Evidence from multi-omics profiling, experimental and epidemiological validation.
The β2-adrenoceptor agonist formoterol reverses metabolic dysfunction in the diabetic proximal tubule.
NAMPT modulates muscle fiber type transition in PAD myopathy via the cGMP-PKG signaling pathway.
Hyperosmolarity-Induced Oxidative Stress Leads to Senescence in Human Corneal Epithelial Cells (HCEPC) via DNA Damage, Metabolic Disturbance and Mitophagy Decline.
Mitochondrial NAD(+) deficiency in vascular smooth muscle impairs collagen III turnover to trigger thoracic and abdominal aortic aneurysm.
Targeting NAMPT-OPA1 for treatment of senile osteoporosis.
Uncovering Hippo pathway-related biomarkers in acute myocardial infarction via scRNA-seq binding transcriptomics.
Apoptotic vesicles derived from bone marrow mesenchymal stem cells increase angiogenesis in a hind limb ischemia model via the NAMPT/SIRT1/FOXO1 axis.
Buyang Huanwu Decoction improves energy metabolism disorders after cerebral ischemia-reperfusion by regulating the SIRT1/AMPK signaling pathway to promote glycolysis and the tricarboxylic acid cycle.
Erythropoietin (EPO) Alleviates Chronic Stress-Induced Depression by Modulating SIRT1-Mediated Mitochondrial Function.
Enhanced tumor suppression in patient-derived temozolomide-resistant glioblastoma cells using a combination treatment of Olaparib and FK866.
Targeting NAD+ Metabolism Vulnerability in FH-Deficient Hereditary Leiomyomatosis and Renal Cell Carcinoma with the Novel NAMPT Inhibitor OT-82.
Exosomal NAMPT from Engineered Mesenchymal Stem Cells Mitigates Aortic Stenosis via Metabolic and Anti-Inflammatory Pathways.
Intestinal Fut2 deficiency exacerbated alcohol-related liver disease by disrupting nicotinamide metabolism.
Ring Finger Protein 2 Promotes Oxidative Stress and Mitochondrial Dysfunction in Doxorubicin-Induced Cardiotoxicity Via the Mercaptopyruvate Sulfurtransferase/Hydrogen Sulfide Pathway.
Tetramethylpyrazine: A fermented alcohol product that mitigates alcoholic liver disease in mice.
Thermal proteome profiling (TPP) reveals NAMPT as the anti-glioma target of phenanthroindolizidine alkaloid PF403.
Regulatory effect and mechanism of CircSEC24A in IL-1β-induced osteoarthritis.
NAD(+) Metabolism Reprogramming Drives SIRT1-Dependent Deacetylation Inducing PD-L1 Nuclear Localization in Cervical Cancer.
Signature Proteins in Small Extracellular Vesicles of Granulocytes and CD4(+) T-Cell Subpopulations Identified by Comparative Proteomic Analysis.
Integrated transcriptome and metabolome study reveal the therapeutic effects of nicotinamide riboside and nicotinamide mononucleotide on nonalcoholic fatty liver disease.
NAD(+) supplementation improves mitochondrial functions and normalizes glaucomatous trabecular meshwork features.
NMNATs expression inhibition mediated NAD(+) deficiency plays a critical role in doxorubicin-induced hepatotoxicity in mice.
METTL3-dependent N6-methyladenosine modification is involved in berberine-mediated neuroprotection in ischemic stroke by enhancing the stability of NEAT1 in astrocytes.
Mitochondrial aldehyde dehydrogenase-2 coordinates the hydrogen sulfide - AMPK axis to attenuate high glucose-induced pancreatic β-cell dysfunction by glutathione antioxidant system.
Nicotinamide mononucleotide pretreatment improves long-term isoflurane anesthesia-induced cognitive impairment in mice.
The use of a systems approach to increase NAD(+) in human participants.
Regulatory roles of NAMPT and NAD(+) metabolism in uterine leiomyoma progression: Implications for ECM accumulation, stemness, and microenvironment.
NAMPT Overexpression Drives Cell Growth in Polycystic Liver Disease through Mitochondrial Metabolism Regulation.
The regulatory relationship between NAMPT and PD-L1 in cancer and identification of a dual-targeting inhibitor.
Puromycin-induced kidney injury and subsequent regeneration in adult zebrafish.
Decoding the Intercellular Cross-Talking Between Immune Cells and Renal Innate Cells in Diabetic Kidney Disease by Bioinformatics.
Huangqi-Danshen decoction protects against cisplatin-induced acute kidney injury in mice.
TRAF3IP2 drives mesenchymal stem cell senescence via regulation of NAMPT-mediated NAD biosynthesis.
Miquelianin in Folium Nelumbinis extract promotes white-to-beige fat conversion via blocking AMPK/DRP1/mitophagy and modulating gut microbiota in HFD-fed mice.
NAD(+) rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis.
SZC-6, a small-molecule activator of SIRT3, attenuates cardiac hypertrophy in mice.
Targeting NAD metabolism regulates extracellular adenosine levels to improve the cytotoxicity of CD8+ effector T cells in the tumor microenvironment of gastric cancer.
NAMPT encapsulated by extracellular vesicles from young adipose-derived mesenchymal stem cells treated tendinopathy in a "One-Stone-Two-Birds" manner.
The Adipokine Visfatin Modulates Cancer Stem Cell Properties in Triple-Negative Breast Cancer.
The NAMPT Inhibitor FK866 in Combination with Cisplatin Reduces Cholangiocarcinoma Cells Growth.
High Concentrations of Nucleotides Prevent Capillary Regression during Hindlimb Unloading by Inhibiting Oxidative Stress and Enhancing Mitochondrial Metabolism of Soleus Muscles in Rats.
Jian-Pi-Yi-Shen formula alleviates renal fibrosis by restoring NAD+ biosynthesis in vivo and in vitro.
NAMPT mediates PDGF-induced pulmonary arterial smooth muscle cell proliferation by TLR4/NF-κB/PLK4 signaling pathway.
Comparative Proteomics Reveals Prolonged Corneal Preservation Impaired Ocular Surface Immunity Accompanied by Fibrosis in Human Stroma.
High-Dosage NMN Promotes Ferroptosis to Suppress Lung Adenocarcinoma Growth through the NAM-Mediated SIRT1-AMPK-ACC Pathway.
Circular RNA triple functional domain promotes osteoarthritis' development by modulating the microRNA-136-5p/Nicotinamide phosphoribosyltransferase axis.
NAD(+) Anabolism Disturbance Causes Glomerular Mesangial Cell Injury in Diabetic Nephropathy.
Glucose-6-phosphate dehydrogenase exerts antistress effects independently of its enzymatic activity.
Astrocyte-derived exosomal nicotinamide phosphoribosyltransferase (Nampt) ameliorates ischemic stroke injury by targeting AMPK/mTOR signaling to induce autophagy.
Inhibition of Pre-B Cell Colony Enhancing Factor Reduces Lung Injury in Rats Receiving Cardiopulmonary Bypass.
Impaired Nicotinamide Adenine Dinucleotide Biosynthesis in the Kidney of Chronic Kidney Disease.
Nicotinamide improves NAD(+) levels to protect against acetaminophen-induced acute liver injury in mice.
Hyperglycemia-reduced NAD(+) biosynthesis impairs corneal epithelial wound healing in diabetic mice.
NAD(+) Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion.
CD38 and MGluR1 as possible signaling molecules involved in epileptogenesis: A potential role for NAD(+) homeostasis.
Nicotinamide Riboside Enhances Mitochondrial Proteostasis and Adult Neurogenesis through Activation of Mitochondrial Unfolded Protein Response Signaling in the Brain of ALS SOD1(G93A) Mice.
Trimetazidine Inhibits Renal Tubular Epithelial Cells to Mesenchymal Transition in Diabetic Rats via Upregulation of Sirt1.
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) with OT-82 induces DNA damage, cell death, and suppression of tumor growth in preclinical models of Ewing sarcoma.
NAMPT and NAPRT, Key Enzymes in NAD Salvage Synthesis Pathway, Are of Negative Prognostic Value in Colorectal Cancer.
NAMPT overexpression alleviates alcohol-induced hepatic steatosis in mice.
Dietary Antioxidant Trans-Cinnamaldehyde Reduced Visfatin-Induced Breast Cancer Progression: In Vivo and In Vitro Study.
Corneal Denervation Causes Epithelial Apoptosis Through Inhibiting NAD+ Biosynthesis.
Exogenous H(2)S switches cardiac energy substrate metabolism by regulating SIRT3 expression in db/db mice.
NMNAT3 is involved in the protective effect of SIRT3 in Ang II-induced cardiac hypertrophy.
Effect of curcumin on visfatin and zinc-α2-glycoprotein in a rat model of non-alcoholic fatty liver disease.
Hepatic NAD(+) deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing.
Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage.
Warasnhe K, Sano A, Guo Q, Satthawiwat N, Dai X, Classon PA, Meroueh C, Kim Lee HS, Valenzuela-Pérez L, Victorelli S, Bamidele AO, Hirsova P, Povero D, Ibrahim SH
Cellular and molecular gastroenterology and hepatology 2026;20(1):101633
Cellular and molecular gastroenterology and hepatology 2026;20(1):101633
METTL1-deficient mesenchymal stem cells protect against metabolic-associated fatty liver disease by increasing NAMPT secretion.
Du J, Zhang Y, Wang C, Wang Y, Zhang H, Zhao D, Lin J
Stem cells translational medicine 2026 Mar 23;15(4)
Stem cells translational medicine 2026 Mar 23;15(4)
SIRT1 mediates brain metabolic and developmental consequences of methionine synthase deficiency in inborn errors of cobalamin metabolism.
Matmat K, Hassan Z, Pourié G, Atlasi Y, Seal SV, Jeandel M, Arnold C, Luharia S, Umoret R, Safar R, Heinken A, Alberto JM, Baspinar O, Paoli J, Hergalant S, Rouyer P, Camadro JM, Lignières L, Coelho D, Guéant JL, Guéant-Rodriguez RM
Cell reports. Medicine 2026 Mar 17;7(3):102643
Cell reports. Medicine 2026 Mar 17;7(3):102643
Administration of Nicotinamide Mononucleotide Mitigates the HIV Nef-Induced Metabolic and Pathological Changes in the Heart.
Kondrachuk O, Nakhungu E, Ogundipe G, Tailor N, Ciccone P, Hong K, Gadiraju A, Kimura Y, Zi A, Yusuf S, Alkousa A, Nguyen S, Rajkumar R, Do J, Rappaport J, Gupta MK
Cells 2026 Mar 1;15(5)
Cells 2026 Mar 1;15(5)
Curcumin inhibits colorectal cancer progression by regulating MDH2-mediated glycolysis and NAD(+) metabolism.
Zhao Y, Qin H, Sun W, Chen Y, Wang R, Li C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2026 Jul;213:116074
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2026 Jul;213:116074
Swietenine alleviated cardiomyocyte inflammation in diabetic cardiomyopathy by regulating NAMPT/SIRT1.
Huang Y, Zhang T, Lu Z, Li S, Wei R, Li W, Shan Y, Liu Y, Zhang C, Yang T, Yan M
International immunopharmacology 2026 Jan 1;168(Pt 1):115823
International immunopharmacology 2026 Jan 1;168(Pt 1):115823
Targeting NAD(+) Salvage Suppresses PBMC Inflammation to Improve Cognitive Function in Vascular Cognitive Impairment.
Li Z, Zhang HY, Feng R, Qi WX, Wang YT, Li Q, Zhang K
Stroke 2026 Feb;57(2):478-492
Stroke 2026 Feb;57(2):478-492
NMN/NAD(+)/SIRT1 axis activates NAMPT to ameliorate H(2)O(2)-triggered the impairment of progesterone synthesis in ovarian granulosa cells.
Wang Y, Li Q, Li Y, Ma Z, Xu H, Chen K, Li J, Lan D, Fu W
Journal of ovarian research 2026 Feb 28;19(1)
Journal of ovarian research 2026 Feb 28;19(1)
NAD(+) sensing by PARP7 regulates the C/EBPβ-dependent transcription program during adipogenesis.
Stokes MS, Kim YJ, Kim Y, Koul S, Chiu SP, Liu C, Dasovich M, Zuniga J, Nandu T, Huang D, Mathews TP, Solmonson A, Camacho CV, Kraus WL
Cell reports 2026 Feb 24;45(2):116929
Cell reports 2026 Feb 24;45(2):116929
Circadian rhythm disruption impairs ovarian follicular development via NAD(+) metabolic reprogramming.
Ying YY, Chen X, Yao SY, Chen RX, Ying Y, Qiu H, Xu QQ, Li ZY, Ye CQ, Qian YL, Liang HQ, Sun X, Zhang D
EBioMedicine 2026 Apr;126:106200
EBioMedicine 2026 Apr;126:106200
NAMPT improves high-fat diet-induced nonalcoholic fatty liver disease (NAFLD) via the SIRT1-C/EBPβ-STEAP4-NRF2 axis.
Zhao J, Li Q, Wang Y, Liu B, Gui S, Zheng Y, Chen X
Journal of molecular cell biology 2026 Apr 3;17(10)
Journal of molecular cell biology 2026 Apr 3;17(10)
Dual Single-Atom Engineered NADH Oxidase-Mimic Boosts In Situ NAD(+) Biotransformation for Targeted Myocardial Ischemia/Reperfusion Protection.
Liu J, Guo X, Wang N, Zhang X, Wang X, Li G, Hou X, Yu L, Chen Y, Li R
Advanced materials (Deerfield Beach, Fla.) 2026 Apr 21;:e19122
Advanced materials (Deerfield Beach, Fla.) 2026 Apr 21;:e19122
The role of the gut microbiota and the nicotinate/nicotinamide pathway in rotenone-induced neurotoxicity.
Sai Y, Ge W, Zhong L, Zhang Q, Xiao J, Shan Y, Ye W, Liu H, Liu S, Ye F, Wang X, Tang H, Zhao Y, Dan G
Current research in toxicology 2025;8:100212
Current research in toxicology 2025;8:100212
NAMPT Impairs Vascular Permeability in Periodontitis by Influencing FASN-mediated Lipogenesis.
Xiao Y, Ma J, Li Z, Gou H, Chen X, Zhou Y, Shen M, Li L, Xu Y
International journal of biological sciences 2025;21(6):2707-2724
International journal of biological sciences 2025;21(6):2707-2724
The eNAMPT-Integrin α5β1 Axis Mediates Neutrophil-Endothelial Cell Interactions Driving Inflammation in Ulcerative Colitis.
Di Y, Ji W, Xiong W, Song W, Chen G, Li D, Qi F
Journal of inflammation research 2025;18:18307-18321
Journal of inflammation research 2025;18:18307-18321
Alisol A ameliorates vascular cognitive impairment via AMPK/NAMPT/SIRT1-mediated regulation of cholesterol and autophagy.
Xu P, Zhou W, Wang S, Wang L, Bai Y, Xing S, Xue W, Li M, Shi J, Wu H
Theranostics 2025;15(18):9415-9446
Theranostics 2025;15(18):9415-9446
Nicotinamide metabolic dysregulation plays a key role in Benzo[a]pyrene-induced adverse birth outcomes: Evidence from multi-omics profiling, experimental and epidemiological validation.
Zhao N, Song W, Sun T, Wu W, Feng Y, Ma N, Wang S
Journal of hazardous materials 2025 Sep 28;498:140000
Journal of hazardous materials 2025 Sep 28;498:140000
The β2-adrenoceptor agonist formoterol reverses metabolic dysfunction in the diabetic proximal tubule.
Cleveland KH, Scholpa NE, Schnellmann RG
The Journal of pharmacology and experimental therapeutics 2025 Oct;392(10):103698
The Journal of pharmacology and experimental therapeutics 2025 Oct;392(10):103698
NAMPT modulates muscle fiber type transition in PAD myopathy via the cGMP-PKG signaling pathway.
Yang Q, Shi Y, Li W, Xiong X, Chen Q, Zheng M
Biology direct 2025 Nov 27;20(1):113
Biology direct 2025 Nov 27;20(1):113
Hyperosmolarity-Induced Oxidative Stress Leads to Senescence in Human Corneal Epithelial Cells (HCEPC) via DNA Damage, Metabolic Disturbance and Mitophagy Decline.
Zhang Y, Fan T
Antioxidants (Basel, Switzerland) 2025 Nov 19;14(11)
Antioxidants (Basel, Switzerland) 2025 Nov 19;14(11)
Mitochondrial NAD(+) deficiency in vascular smooth muscle impairs collagen III turnover to trigger thoracic and abdominal aortic aneurysm.
Zhang J, Tang Y, Zhang S, Xie Z, Ma W, Liu S, Fang Y, Zheng S, Huang C, Yan G, Abudupataer M, Xin Y, Zhu J, Han W, Wang W, Shen F, Lai H, Liu Y, Ye D, Yu FX, Xu Y, Pan C, Wang C, Zhu K, Zhang W
Nature cardiovascular research 2025 Mar;4(3):275-292
Nature cardiovascular research 2025 Mar;4(3):275-292
Targeting NAMPT-OPA1 for treatment of senile osteoporosis.
Bai CW, Tian B, Zhang MC, Qin Q, Shi X, Yang X, Gao X, Zhou XZ, Shan HJ, Bai JY
Aging cell 2025 Mar;24(3):e14400
Aging cell 2025 Mar;24(3):e14400
Uncovering Hippo pathway-related biomarkers in acute myocardial infarction via scRNA-seq binding transcriptomics.
Li X, He X, Zhang Y, Hao X, Xiong A, Huang J, Jiang B, Tong Z, Huang H, Yi L, Chen W
Scientific reports 2025 Mar 26;15(1):10368
Scientific reports 2025 Mar 26;15(1):10368
Apoptotic vesicles derived from bone marrow mesenchymal stem cells increase angiogenesis in a hind limb ischemia model via the NAMPT/SIRT1/FOXO1 axis.
Chen J, Shen Z, Chen B, Liu S, Mei Y, Li K, Peng Z, Feng C, Wang W, Lu S
Stem cell research & therapy 2025 Mar 1;16(1):105
Stem cell research & therapy 2025 Mar 1;16(1):105
Buyang Huanwu Decoction improves energy metabolism disorders after cerebral ischemia-reperfusion by regulating the SIRT1/AMPK signaling pathway to promote glycolysis and the tricarboxylic acid cycle.
Hu Z, Deng N, Li Y, Bai Y, Lan X, Xiong T, Ding H, Liu X, Deng C
Chinese medicine 2025 Jul 7;20(1):108
Chinese medicine 2025 Jul 7;20(1):108
Erythropoietin (EPO) Alleviates Chronic Stress-Induced Depression by Modulating SIRT1-Mediated Mitochondrial Function.
Luo Y, Ali T, Hu Y, Gong Q, Zheng C, Li L, Li S, Hao L
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2025 Jul 21;20(1):73
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2025 Jul 21;20(1):73
Enhanced tumor suppression in patient-derived temozolomide-resistant glioblastoma cells using a combination treatment of Olaparib and FK866.
Sha X, Li J, Fang Y, Feng J, Feng Y, Wang J, Si Y, Li F, Cheng S, Ding W
BMC cancer 2025 Jul 15;25(1):1174
BMC cancer 2025 Jul 15;25(1):1174
Targeting NAD+ Metabolism Vulnerability in FH-Deficient Hereditary Leiomyomatosis and Renal Cell Carcinoma with the Novel NAMPT Inhibitor OT-82.
Najera SS, Ricketts CJ, Schmidt LS, Medina JI, Saito K, Ileva L, Brender JR, James AM, Peer CJ, Gouker B, Karim BO, Chernova O, Wells C, Wei MH, Yang Y, Zhang X, Klumpp-Thomas C, Travers J, Chen L, Wilson KM, Issaq SH, Figg WD, Difilippantonio S, Kalen JD, Krishna MC, Thomas CJ, Ceribelli M, Heske CM, Crooks DR, Meier JL
Molecular cancer therapeutics 2025 Feb 4;24(2):200-213
Molecular cancer therapeutics 2025 Feb 4;24(2):200-213
Exosomal NAMPT from Engineered Mesenchymal Stem Cells Mitigates Aortic Stenosis via Metabolic and Anti-Inflammatory Pathways.
Kundu DK, Kiedrowski M, Gadd J, Gao M, Evan M, Wang Y, Yin L, Ohanyan V, Chilian WM, Dong F
International journal of molecular sciences 2025 Dec 25;27(1)
International journal of molecular sciences 2025 Dec 25;27(1)
Intestinal Fut2 deficiency exacerbated alcohol-related liver disease by disrupting nicotinamide metabolism.
Chen L, Yin Z, Shang L, Yuan H, Gao W, Wang S, Wang S, Hou X, Yang S, Chu H
Clinical and translational medicine 2025 Aug;15(8):e70447
Clinical and translational medicine 2025 Aug;15(8):e70447
Ring Finger Protein 2 Promotes Oxidative Stress and Mitochondrial Dysfunction in Doxorubicin-Induced Cardiotoxicity Via the Mercaptopyruvate Sulfurtransferase/Hydrogen Sulfide Pathway.
Zhong Y, Fan D, Zhang P, Mao X, Liu B, Wang C, Li Q
Journal of the American Heart Association 2025 Aug 19;14(16):e041440
Journal of the American Heart Association 2025 Aug 19;14(16):e041440
Tetramethylpyrazine: A fermented alcohol product that mitigates alcoholic liver disease in mice.
Pu Q, Gao H, Xiao D, Wang M, Yang Z, He Q, Liu M, Zhu X, Pan T, Ma Z, Wang J, Liu Y
Free radical biology & medicine 2025 Aug 16;236:160-175
Free radical biology & medicine 2025 Aug 16;236:160-175
Thermal proteome profiling (TPP) reveals NAMPT as the anti-glioma target of phenanthroindolizidine alkaloid PF403.
Li F, Zhang Z, Shi Q, Wang R, Ji M, Chen X, Li Y, Liu Y, Yu S
Acta pharmaceutica Sinica. B 2025 Apr;15(4):2008-2023
Acta pharmaceutica Sinica. B 2025 Apr;15(4):2008-2023
Regulatory effect and mechanism of CircSEC24A in IL-1β-induced osteoarthritis.
Wang Y, Chen X, Chen Y, Sun Q, Wang H
Archives of physiology and biochemistry 2025 Apr;131(2):188-198
Archives of physiology and biochemistry 2025 Apr;131(2):188-198
NAD(+) Metabolism Reprogramming Drives SIRT1-Dependent Deacetylation Inducing PD-L1 Nuclear Localization in Cervical Cancer.
Lu X, Jin P, Tang Q, Zhou M, Xu H, Su C, Wang L, Xu F, Zhao M, Yin Y, Zhang J, Jia Z, Peng X, Zhou J, Wang L, Chen Y, Wang M, Yang M, Chen D, Chen Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2412109
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2412109
Signature Proteins in Small Extracellular Vesicles of Granulocytes and CD4(+) T-Cell Subpopulations Identified by Comparative Proteomic Analysis.
Vázquez-Mera S, Miguéns-Suárez P, Martelo-Vidal L, Rivas-López S, Uller L, Bravo SB, Domínguez-Arca V, Muñoz X, González-Barcala FJ, Nieto Fontarigo JJ, Salgado FJ
International journal of molecular sciences 2024 Oct 9;25(19)
International journal of molecular sciences 2024 Oct 9;25(19)
Integrated transcriptome and metabolome study reveal the therapeutic effects of nicotinamide riboside and nicotinamide mononucleotide on nonalcoholic fatty liver disease.
Zhang J, Chen F
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jun;175:116701
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jun;175:116701
NAD(+) supplementation improves mitochondrial functions and normalizes glaucomatous trabecular meshwork features.
Liu Y, Bu Q, Hu D, Chen C, Zhu J, Zhou Q, Li Z, Pan X
Experimental cell research 2024 Jul 1;440(1):114137
Experimental cell research 2024 Jul 1;440(1):114137
NMNATs expression inhibition mediated NAD(+) deficiency plays a critical role in doxorubicin-induced hepatotoxicity in mice.
Cheng F, Zhang Y, Xiong H, Zhao M, Wang Q, Zhu Y, Li Y, Tang R, Li J
Toxicology and applied pharmacology 2024 Jan;482:116799
Toxicology and applied pharmacology 2024 Jan;482:116799
METTL3-dependent N6-methyladenosine modification is involved in berberine-mediated neuroprotection in ischemic stroke by enhancing the stability of NEAT1 in astrocytes.
Hu J, Duan H, Zou J, Ding W, Wei Z, Peng Q, Li Z, Duan R, Sun J, Zhu J
Aging 2024 Jan 4;16(1):299-321
Aging 2024 Jan 4;16(1):299-321
Mitochondrial aldehyde dehydrogenase-2 coordinates the hydrogen sulfide - AMPK axis to attenuate high glucose-induced pancreatic β-cell dysfunction by glutathione antioxidant system.
Karunakaran U, Elumalai S, Chung SM, Maedler K, Won KC, Moon JS
Redox biology 2024 Feb;69:102994
Redox biology 2024 Feb;69:102994
Nicotinamide mononucleotide pretreatment improves long-term isoflurane anesthesia-induced cognitive impairment in mice.
Xu J, Chen X, Liu S, Wei Z, Xu M, Jiang L, Han X, Peng L, Gu X, Xia T
Behavioural brain research 2024 Feb 26;458:114738
Behavioural brain research 2024 Feb 26;458:114738
The use of a systems approach to increase NAD(+) in human participants.
Henderson JD, Quigley SNZ, Chachra SS, Conlon N, Ford D
npj aging 2024 Feb 1;10(1):7
npj aging 2024 Feb 1;10(1):7
Regulatory roles of NAMPT and NAD(+) metabolism in uterine leiomyoma progression: Implications for ECM accumulation, stemness, and microenvironment.
Chiang YF, Huang KC, Huang TC, Chen HY, Ali M, Al-Hendy A, Huang PS, Hsia SM
Redox biology 2024 Dec;78:103411
Redox biology 2024 Dec;78:103411
NAMPT Overexpression Drives Cell Growth in Polycystic Liver Disease through Mitochondrial Metabolism Regulation.
Pant K, Gradilone SA
The American journal of pathology 2024 Aug;194(8):1528-1537
The American journal of pathology 2024 Aug;194(8):1528-1537
The regulatory relationship between NAMPT and PD-L1 in cancer and identification of a dual-targeting inhibitor.
Yang Y, Li Z, Wang Y, Gao J, Meng Y, Wang S, Zhao X, Tang C, Yang W, Li Y, Bao J, Fan X, Tang J, Yang J, Wu C, Qin M, Wang L
EMBO molecular medicine 2024 Apr;16(4):885-903
EMBO molecular medicine 2024 Apr;16(4):885-903
Puromycin-induced kidney injury and subsequent regeneration in adult zebrafish.
Koun S, Park HJ, Jung SM, Cha JJ, Cha DR, Kang YS
Animal cells and systems 2023;27(1):112-119
Animal cells and systems 2023;27(1):112-119
Decoding the Intercellular Cross-Talking Between Immune Cells and Renal Innate Cells in Diabetic Kidney Disease by Bioinformatics.
Zhou M, Lu F, Jiang L, Chen C, Chen S, Geng L, Sun R, Li Q, Duan S, Zhang B, Mao H, Xing C, Yuan Y
Journal of inflammation research 2023;16:3049-3062
Journal of inflammation research 2023;16:3049-3062
Huangqi-Danshen decoction protects against cisplatin-induced acute kidney injury in mice.
Liu X, Gao L, Huang X, Deng R, Wu S, Peng Y, Lu J
Frontiers in pharmacology 2023;14:1236820
Frontiers in pharmacology 2023;14:1236820
TRAF3IP2 drives mesenchymal stem cell senescence via regulation of NAMPT-mediated NAD biosynthesis.
Huang X, Liu B, Liang Y, Mai C, Shen Y, Huang X, Chen J, Liang X, Hu B, Li W, Li X, Zhang Y
Heliyon 2023 Sep;9(9):e19505
Heliyon 2023 Sep;9(9):e19505
Miquelianin in Folium Nelumbinis extract promotes white-to-beige fat conversion via blocking AMPK/DRP1/mitophagy and modulating gut microbiota in HFD-fed mice.
Wang Z, Yang T, Zeng M, Wang Z, Chen Q, Chen J, Christian M, He Z
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Nov;181:114089
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Nov;181:114089
NAD(+) rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis.
Zhan R, Meng X, Tian D, Xu J, Cui H, Yang J, Xu Y, Shi M, Xue J, Yu W, Hu G, Li K, Ge X, Zhang Q, Zhao M, Du J, Guo X, Xu W, Gao Y, Yao C, Chen F, Chen Y, Shan W, Zhu Y, Ji L, Pan B, Yu Y, Li W, Zhao X, He Q, Liu X, Huang Y, Liao S, Zhou B, Chui D, Chen YE, Sun Z, Dong E, Wang Y, Zheng L
Neuron 2023 Nov 15;111(22):3634-3649.e7
Neuron 2023 Nov 15;111(22):3634-3649.e7
SZC-6, a small-molecule activator of SIRT3, attenuates cardiac hypertrophy in mice.
Li ZY, Lu GQ, Lu J, Wang PX, Zhang XL, Zou Y, Liu PQ
Acta pharmacologica Sinica 2023 Mar;44(3):546-560
Acta pharmacologica Sinica 2023 Mar;44(3):546-560
Targeting NAD metabolism regulates extracellular adenosine levels to improve the cytotoxicity of CD8+ effector T cells in the tumor microenvironment of gastric cancer.
Liu HY, Wang FH, Liang JM, Xiang YY, Liu SH, Zhang SW, Zhu CM, He YL, Zhang CH
Journal of cancer research and clinical oncology 2023 Jul;149(7):2743-2756
Journal of cancer research and clinical oncology 2023 Jul;149(7):2743-2756
NAMPT encapsulated by extracellular vesicles from young adipose-derived mesenchymal stem cells treated tendinopathy in a "One-Stone-Two-Birds" manner.
Wu G, Su Q, Li J, Xue C, Zhu J, Cai Q, Huang J, Ji S, Cheng B, Ge H
Journal of nanobiotechnology 2023 Jan 5;21(1):7
Journal of nanobiotechnology 2023 Jan 5;21(1):7
The Adipokine Visfatin Modulates Cancer Stem Cell Properties in Triple-Negative Breast Cancer.
Chiang YF, Huang KC, Chen HY, Huang TC, Ali M, Chang HY, Shieh TM, Shih YH, Wang KL, Huang YJ, Chung CP, Hsia SM
Biomedicines 2023 Jan 20;11(2)
Biomedicines 2023 Jan 20;11(2)
The NAMPT Inhibitor FK866 in Combination with Cisplatin Reduces Cholangiocarcinoma Cells Growth.
Pant K, Richard S, Peixoto E, Yin J, Seelig DM, Carotenuto P, Salati M, Franco B, Roberts LR, Gradilone SA
Cells 2023 Feb 28;12(5)
Cells 2023 Feb 28;12(5)
High Concentrations of Nucleotides Prevent Capillary Regression during Hindlimb Unloading by Inhibiting Oxidative Stress and Enhancing Mitochondrial Metabolism of Soleus Muscles in Rats.
Nakanishi R, Hashimoto N, Takuwa M, Xing J, Uemura M, Un Nisa B, Tanaka M, Hirabayashi T, Tanaka M, Fujino H
Acta histochemica et cytochemica 2023 Dec 28;56(6):95-104
Acta histochemica et cytochemica 2023 Dec 28;56(6):95-104
Jian-Pi-Yi-Shen formula alleviates renal fibrosis by restoring NAD+ biosynthesis in vivo and in vitro.
Gao L, Huang X, Deng R, Wu S, Peng Y, Xiong G, Lu J, Liu X
Aging 2023 Dec 28;16(1):106-128
Aging 2023 Dec 28;16(1):106-128
NAMPT mediates PDGF-induced pulmonary arterial smooth muscle cell proliferation by TLR4/NF-κB/PLK4 signaling pathway.
Li D, Chen Y, Wang Y, Liu J, Chai L, Zhang Q, Qiu Y, Chen H, Shen N, Shi X, Li M
European journal of pharmacology 2023 Dec 15;961:176151
European journal of pharmacology 2023 Dec 15;961:176151
Comparative Proteomics Reveals Prolonged Corneal Preservation Impaired Ocular Surface Immunity Accompanied by Fibrosis in Human Stroma.
Wu PS, Liu HY, Wong TH, Lin JT, Hu FR, Lin MH
Journal of proteome research 2023 Dec 1;22(12):3730-3741
Journal of proteome research 2023 Dec 1;22(12):3730-3741
High-Dosage NMN Promotes Ferroptosis to Suppress Lung Adenocarcinoma Growth through the NAM-Mediated SIRT1-AMPK-ACC Pathway.
Zhang M, Cui J, Chen H, Wang Y, Kuai X, Sun S, Tang Q, Zong F, Chen Q, Wu J, Wu S
Cancers 2023 Apr 23;15(9)
Cancers 2023 Apr 23;15(9)
Circular RNA triple functional domain promotes osteoarthritis' development by modulating the microRNA-136-5p/Nicotinamide phosphoribosyltransferase axis.
Yang J, Li Q, Wang T, Lv K
Bioengineered 2022 Mar;13(3):6070-6079
Bioengineered 2022 Mar;13(3):6070-6079
NAD(+) Anabolism Disturbance Causes Glomerular Mesangial Cell Injury in Diabetic Nephropathy.
Li X, Li Y, Li F, Chen Q, Zhao Z, Liu X, Zhang N, Li H
International journal of molecular sciences 2022 Mar 22;23(7)
International journal of molecular sciences 2022 Mar 22;23(7)
Glucose-6-phosphate dehydrogenase exerts antistress effects independently of its enzymatic activity.
Jin X, Li X, Li L, Zhong B, Hong Y, Niu J, Li B
The Journal of biological chemistry 2022 Dec;298(12):102587
The Journal of biological chemistry 2022 Dec;298(12):102587
Astrocyte-derived exosomal nicotinamide phosphoribosyltransferase (Nampt) ameliorates ischemic stroke injury by targeting AMPK/mTOR signaling to induce autophagy.
Deng Y, Duan R, Ding W, Gu Q, Liu M, Zhou J, Sun J, Zhu J
Cell death & disease 2022 Dec 20;13(12):1057
Cell death & disease 2022 Dec 20;13(12):1057
Inhibition of Pre-B Cell Colony Enhancing Factor Reduces Lung Injury in Rats Receiving Cardiopulmonary Bypass.
Lu C, Yang W, Zhou J, Zhang Z, Gong Y, Hu F, Yu W, Dong X
Drug design, development and therapy 2021;15:51-60
Drug design, development and therapy 2021;15:51-60
Impaired Nicotinamide Adenine Dinucleotide Biosynthesis in the Kidney of Chronic Kidney Disease.
Liu X, Luo D, Huang S, Liu S, Zhang B, Wang F, Lu J, Chen J, Li S
Frontiers in physiology 2021;12:723690
Frontiers in physiology 2021;12:723690
Nicotinamide improves NAD(+) levels to protect against acetaminophen-induced acute liver injury in mice.
Xu J, Zhang L, Jiang R, Hu K, Hu D, Liao C, Jiang S, Yang Y, Huang J, Tang L, Li L
Human & experimental toxicology 2021 Nov;40(11):1938-1946
Human & experimental toxicology 2021 Nov;40(11):1938-1946
Hyperglycemia-reduced NAD(+) biosynthesis impairs corneal epithelial wound healing in diabetic mice.
Li Y, Li J, Zhao C, Yang L, Qi X, Wang X, Zhou Q, Shi W
Metabolism: clinical and experimental 2021 Jan;114:154402
Metabolism: clinical and experimental 2021 Jan;114:154402
NAD(+) Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion.
Lv H, Lv G, Chen C, Zong Q, Jiang G, Ye D, Cui X, He Y, Xiang W, Han Q, Tang L, Yang W, Wang H
Cell metabolism 2021 Jan 5;33(1):110-127.e5
Cell metabolism 2021 Jan 5;33(1):110-127.e5
CD38 and MGluR1 as possible signaling molecules involved in epileptogenesis: A potential role for NAD(+) homeostasis.
Khodaverdian S, Dashtban-Moghadam E, Dabirmanesh B, Mirnajafi-Zadeh J, Taleb M, Khajeh K, Fathollahi Y
Brain research 2021 Aug 15;1765:147509
Brain research 2021 Aug 15;1765:147509
Nicotinamide Riboside Enhances Mitochondrial Proteostasis and Adult Neurogenesis through Activation of Mitochondrial Unfolded Protein Response Signaling in the Brain of ALS SOD1(G93A) Mice.
Zhou Q, Zhu L, Qiu W, Liu Y, Yang F, Chen W, Xu R
International journal of biological sciences 2020;16(2):284-297
International journal of biological sciences 2020;16(2):284-297
Trimetazidine Inhibits Renal Tubular Epithelial Cells to Mesenchymal Transition in Diabetic Rats via Upregulation of Sirt1.
Yang Y, Wang Y, He Z, Liu Y, Chen C, Wang Y, Wang DW, Wang H
Frontiers in pharmacology 2020;11:1136
Frontiers in pharmacology 2020;11:1136
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) with OT-82 induces DNA damage, cell death, and suppression of tumor growth in preclinical models of Ewing sarcoma.
Gibson AE, Yeung C, Issaq SH, Collins VJ, Gouzoulis M, Zhang Y, Ji J, Mendoza A, Heske CM
Oncogenesis 2020 Sep 10;9(9):80
Oncogenesis 2020 Sep 10;9(9):80
NAMPT and NAPRT, Key Enzymes in NAD Salvage Synthesis Pathway, Are of Negative Prognostic Value in Colorectal Cancer.
Li XQ, Lei J, Mao LH, Wang QL, Xu F, Ran T, Zhou ZH, He S
Frontiers in oncology 2019;9:736
Frontiers in oncology 2019;9:736
NAMPT overexpression alleviates alcohol-induced hepatic steatosis in mice.
Xiong X, Yu J, Fan R, Zhang C, Xu L, Sun X, Huang Y, Wang Q, Ruan HB, Qian X
PloS one 2019;14(2):e0212523
PloS one 2019;14(2):e0212523
Dietary Antioxidant Trans-Cinnamaldehyde Reduced Visfatin-Induced Breast Cancer Progression: In Vivo and In Vitro Study.
Chiang YF, Chen HY, Huang KC, Lin PH, Hsia SM
Antioxidants (Basel, Switzerland) 2019 Dec 6;8(12)
Antioxidants (Basel, Switzerland) 2019 Dec 6;8(12)
Corneal Denervation Causes Epithelial Apoptosis Through Inhibiting NAD+ Biosynthesis.
Li Y, Ma X, Li J, Yang L, Zhao X, Qi X, Zhang X, Zhou Q, Shi W
Investigative ophthalmology & visual science 2019 Aug 1;60(10):3538-3546
Investigative ophthalmology & visual science 2019 Aug 1;60(10):3538-3546
Exogenous H(2)S switches cardiac energy substrate metabolism by regulating SIRT3 expression in db/db mice.
Sun Y, Tian Z, Liu N, Zhang L, Gao Z, Sun X, Yu M, Wu J, Yang F, Zhao Y, Ren H, Chen H, Zhao D, Wang Y, Dong S, Xu C, Lu F, Zhang W
Journal of molecular medicine (Berlin, Germany) 2018 Apr;96(3-4):281-299
Journal of molecular medicine (Berlin, Germany) 2018 Apr;96(3-4):281-299
NMNAT3 is involved in the protective effect of SIRT3 in Ang II-induced cardiac hypertrophy.
Yue Z, Ma Y, You J, Li Z, Ding Y, He P, Lu X, Jiang J, Chen S, Liu P
Experimental cell research 2016 Oct 1;347(2):261-73
Experimental cell research 2016 Oct 1;347(2):261-73
Effect of curcumin on visfatin and zinc-α2-glycoprotein in a rat model of non-alcoholic fatty liver disease.
Li C, Li J, Chen Y, Zhong X, Kang M
Acta cirurgica brasileira 2016 Nov;31(11):706-713
Acta cirurgica brasileira 2016 Nov;31(11):706-713
Hepatic NAD(+) deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing.
Zhou CC, Yang X, Hua X, Liu J, Fan MB, Li GQ, Song J, Xu TY, Li ZY, Guan YF, Wang P, Miao CY
British journal of pharmacology 2016 Aug;173(15):2352-68
British journal of pharmacology 2016 Aug;173(15):2352-68
Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage.
Tummala KS, Gomes AL, Yilmaz M, Graña O, Bakiri L, Ruppen I, Ximénez-Embún P, Sheshappanavar V, Rodriguez-Justo M, Pisano DG, Wagner EF, Djouder N
Cancer cell 2014 Dec 8;26(6):826-839
Cancer cell 2014 Dec 8;26(6):826-839
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse heart tissue were subjected to SDS PAGE followed by western blot with 11776-1-AP(NAMPT antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-NAMPT (IP:11776-1-AP, 3ug; Detection:11776-1-AP 1:1000) with mouse heart tissue lysate 4000ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Visfatin antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Visfatin. This antibody recognizes human,mouse,rat, zebrafish antigen. The Visfatin antibody has been validated for the following applications: ELISA, IHC, WB, IP analysis.
