Antibody data
- Antibody Data
- Antigen structure
- References [44]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 11776-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11776-1-AP, RRID:AB_2298317
- Product name
- NAMPT/PBEF antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated NAMPT/PBEF antibody (Cat. #11776-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat, zebrafish and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat, Zebrafish
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Integrated transcriptome and metabolome study reveal the therapeutic effects of nicotinamide riboside and nicotinamide mononucleotide on nonalcoholic fatty liver disease.
NAD(+) supplementation improves mitochondrial functions and normalizes glaucomatous trabecular meshwork features.
NMNATs expression inhibition mediated NAD(+) deficiency plays a critical role in doxorubicin-induced hepatotoxicity in mice.
METTL3-dependent N6-methyladenosine modification is involved in berberine-mediated neuroprotection in ischemic stroke by enhancing the stability of NEAT1 in astrocytes.
Mitochondrial aldehyde dehydrogenase-2 coordinates the hydrogen sulfide - AMPK axis to attenuate high glucose-induced pancreatic β-cell dysfunction by glutathione antioxidant system.
Nicotinamide mononucleotide pretreatment improves long-term isoflurane anesthesia-induced cognitive impairment in mice.
The use of a systems approach to increase NAD(+) in human participants.
Puromycin-induced kidney injury and subsequent regeneration in adult zebrafish.
Decoding the Intercellular Cross-Talking Between Immune Cells and Renal Innate Cells in Diabetic Kidney Disease by Bioinformatics.
Huangqi-Danshen decoction protects against cisplatin-induced acute kidney injury in mice.
TRAF3IP2 drives mesenchymal stem cell senescence via regulation of NAMPT-mediated NAD biosynthesis.
Miquelianin in Folium Nelumbinis extract promotes white-to-beige fat conversion via blocking AMPK/DRP1/mitophagy and modulating gut microbiota in HFD-fed mice.
NAD(+) rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis.
SZC-6, a small-molecule activator of SIRT3, attenuates cardiac hypertrophy in mice.
Targeting NAD metabolism regulates extracellular adenosine levels to improve the cytotoxicity of CD8+ effector T cells in the tumor microenvironment of gastric cancer.
NAMPT encapsulated by extracellular vesicles from young adipose-derived mesenchymal stem cells treated tendinopathy in a "One-Stone-Two-Birds" manner.
The Adipokine Visfatin Modulates Cancer Stem Cell Properties in Triple-Negative Breast Cancer.
The NAMPT Inhibitor FK866 in Combination with Cisplatin Reduces Cholangiocarcinoma Cells Growth.
Jian-Pi-Yi-Shen formula alleviates renal fibrosis by restoring NAD+ biosynthesis in vivo and in vitro.
NAMPT mediates PDGF-induced pulmonary arterial smooth muscle cell proliferation by TLR4/NF-κB/PLK4 signaling pathway.
Comparative Proteomics Reveals Prolonged Corneal Preservation Impaired Ocular Surface Immunity Accompanied by Fibrosis in Human Stroma.
High-Dosage NMN Promotes Ferroptosis to Suppress Lung Adenocarcinoma Growth through the NAM-Mediated SIRT1-AMPK-ACC Pathway.
Circular RNA triple functional domain promotes osteoarthritis' development by modulating the microRNA-136-5p/Nicotinamide phosphoribosyltransferase axis.
NAD(+) Anabolism Disturbance Causes Glomerular Mesangial Cell Injury in Diabetic Nephropathy.
Glucose-6-phosphate dehydrogenase exerts antistress effects independently of its enzymatic activity.
Astrocyte-derived exosomal nicotinamide phosphoribosyltransferase (Nampt) ameliorates ischemic stroke injury by targeting AMPK/mTOR signaling to induce autophagy.
Inhibition of Pre-B Cell Colony Enhancing Factor Reduces Lung Injury in Rats Receiving Cardiopulmonary Bypass.
Impaired Nicotinamide Adenine Dinucleotide Biosynthesis in the Kidney of Chronic Kidney Disease.
Nicotinamide improves NAD(+) levels to protect against acetaminophen-induced acute liver injury in mice.
Hyperglycemia-reduced NAD(+) biosynthesis impairs corneal epithelial wound healing in diabetic mice.
NAD(+) Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion.
CD38 and MGluR1 as possible signaling molecules involved in epileptogenesis: A potential role for NAD(+) homeostasis.
Nicotinamide Riboside Enhances Mitochondrial Proteostasis and Adult Neurogenesis through Activation of Mitochondrial Unfolded Protein Response Signaling in the Brain of ALS SOD1(G93A) Mice.
Trimetazidine Inhibits Renal Tubular Epithelial Cells to Mesenchymal Transition in Diabetic Rats via Upregulation of Sirt1.
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) with OT-82 induces DNA damage, cell death, and suppression of tumor growth in preclinical models of Ewing sarcoma.
NAMPT and NAPRT, Key Enzymes in NAD Salvage Synthesis Pathway, Are of Negative Prognostic Value in Colorectal Cancer.
NAMPT overexpression alleviates alcohol-induced hepatic steatosis in mice.
Dietary Antioxidant Trans-Cinnamaldehyde Reduced Visfatin-Induced Breast Cancer Progression: In Vivo and In Vitro Study.
Corneal Denervation Causes Epithelial Apoptosis Through Inhibiting NAD+ Biosynthesis.
Exogenous H(2)S switches cardiac energy substrate metabolism by regulating SIRT3 expression in db/db mice.
NMNAT3 is involved in the protective effect of SIRT3 in Ang II-induced cardiac hypertrophy.
Effect of curcumin on visfatin and zinc-α2-glycoprotein in a rat model of non-alcoholic fatty liver disease.
Hepatic NAD(+) deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing.
Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage.
Zhang J, Chen F
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jun;175:116701
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jun;175:116701
NAD(+) supplementation improves mitochondrial functions and normalizes glaucomatous trabecular meshwork features.
Liu Y, Bu Q, Hu D, Chen C, Zhu J, Zhou Q, Li Z, Pan X
Experimental cell research 2024 Jul 1;440(1):114137
Experimental cell research 2024 Jul 1;440(1):114137
NMNATs expression inhibition mediated NAD(+) deficiency plays a critical role in doxorubicin-induced hepatotoxicity in mice.
Cheng F, Zhang Y, Xiong H, Zhao M, Wang Q, Zhu Y, Li Y, Tang R, Li J
Toxicology and applied pharmacology 2024 Jan;482:116799
Toxicology and applied pharmacology 2024 Jan;482:116799
METTL3-dependent N6-methyladenosine modification is involved in berberine-mediated neuroprotection in ischemic stroke by enhancing the stability of NEAT1 in astrocytes.
Hu J, Duan H, Zou J, Ding W, Wei Z, Peng Q, Li Z, Duan R, Sun J, Zhu J
Aging 2024 Jan 4;16(1):299-321
Aging 2024 Jan 4;16(1):299-321
Mitochondrial aldehyde dehydrogenase-2 coordinates the hydrogen sulfide - AMPK axis to attenuate high glucose-induced pancreatic β-cell dysfunction by glutathione antioxidant system.
Karunakaran U, Elumalai S, Chung SM, Maedler K, Won KC, Moon JS
Redox biology 2024 Feb;69:102994
Redox biology 2024 Feb;69:102994
Nicotinamide mononucleotide pretreatment improves long-term isoflurane anesthesia-induced cognitive impairment in mice.
Xu J, Chen X, Liu S, Wei Z, Xu M, Jiang L, Han X, Peng L, Gu X, Xia T
Behavioural brain research 2024 Feb 26;458:114738
Behavioural brain research 2024 Feb 26;458:114738
The use of a systems approach to increase NAD(+) in human participants.
Henderson JD, Quigley SNZ, Chachra SS, Conlon N, Ford D
npj aging 2024 Feb 1;10(1):7
npj aging 2024 Feb 1;10(1):7
Puromycin-induced kidney injury and subsequent regeneration in adult zebrafish.
Koun S, Park HJ, Jung SM, Cha JJ, Cha DR, Kang YS
Animal cells and systems 2023;27(1):112-119
Animal cells and systems 2023;27(1):112-119
Decoding the Intercellular Cross-Talking Between Immune Cells and Renal Innate Cells in Diabetic Kidney Disease by Bioinformatics.
Zhou M, Lu F, Jiang L, Chen C, Chen S, Geng L, Sun R, Li Q, Duan S, Zhang B, Mao H, Xing C, Yuan Y
Journal of inflammation research 2023;16:3049-3062
Journal of inflammation research 2023;16:3049-3062
Huangqi-Danshen decoction protects against cisplatin-induced acute kidney injury in mice.
Liu X, Gao L, Huang X, Deng R, Wu S, Peng Y, Lu J
Frontiers in pharmacology 2023;14:1236820
Frontiers in pharmacology 2023;14:1236820
TRAF3IP2 drives mesenchymal stem cell senescence via regulation of NAMPT-mediated NAD biosynthesis.
Huang X, Liu B, Liang Y, Mai C, Shen Y, Huang X, Chen J, Liang X, Hu B, Li W, Li X, Zhang Y
Heliyon 2023 Sep;9(9):e19505
Heliyon 2023 Sep;9(9):e19505
Miquelianin in Folium Nelumbinis extract promotes white-to-beige fat conversion via blocking AMPK/DRP1/mitophagy and modulating gut microbiota in HFD-fed mice.
Wang Z, Yang T, Zeng M, Wang Z, Chen Q, Chen J, Christian M, He Z
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Nov;181:114089
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Nov;181:114089
NAD(+) rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis.
Zhan R, Meng X, Tian D, Xu J, Cui H, Yang J, Xu Y, Shi M, Xue J, Yu W, Hu G, Li K, Ge X, Zhang Q, Zhao M, Du J, Guo X, Xu W, Gao Y, Yao C, Chen F, Chen Y, Shan W, Zhu Y, Ji L, Pan B, Yu Y, Li W, Zhao X, He Q, Liu X, Huang Y, Liao S, Zhou B, Chui D, Chen YE, Sun Z, Dong E, Wang Y, Zheng L
Neuron 2023 Nov 15;111(22):3634-3649.e7
Neuron 2023 Nov 15;111(22):3634-3649.e7
SZC-6, a small-molecule activator of SIRT3, attenuates cardiac hypertrophy in mice.
Li ZY, Lu GQ, Lu J, Wang PX, Zhang XL, Zou Y, Liu PQ
Acta pharmacologica Sinica 2023 Mar;44(3):546-560
Acta pharmacologica Sinica 2023 Mar;44(3):546-560
Targeting NAD metabolism regulates extracellular adenosine levels to improve the cytotoxicity of CD8+ effector T cells in the tumor microenvironment of gastric cancer.
Liu HY, Wang FH, Liang JM, Xiang YY, Liu SH, Zhang SW, Zhu CM, He YL, Zhang CH
Journal of cancer research and clinical oncology 2023 Jul;149(7):2743-2756
Journal of cancer research and clinical oncology 2023 Jul;149(7):2743-2756
NAMPT encapsulated by extracellular vesicles from young adipose-derived mesenchymal stem cells treated tendinopathy in a "One-Stone-Two-Birds" manner.
Wu G, Su Q, Li J, Xue C, Zhu J, Cai Q, Huang J, Ji S, Cheng B, Ge H
Journal of nanobiotechnology 2023 Jan 5;21(1):7
Journal of nanobiotechnology 2023 Jan 5;21(1):7
The Adipokine Visfatin Modulates Cancer Stem Cell Properties in Triple-Negative Breast Cancer.
Chiang YF, Huang KC, Chen HY, Huang TC, Ali M, Chang HY, Shieh TM, Shih YH, Wang KL, Huang YJ, Chung CP, Hsia SM
Biomedicines 2023 Jan 20;11(2)
Biomedicines 2023 Jan 20;11(2)
The NAMPT Inhibitor FK866 in Combination with Cisplatin Reduces Cholangiocarcinoma Cells Growth.
Pant K, Richard S, Peixoto E, Yin J, Seelig DM, Carotenuto P, Salati M, Franco B, Roberts LR, Gradilone SA
Cells 2023 Feb 28;12(5)
Cells 2023 Feb 28;12(5)
Jian-Pi-Yi-Shen formula alleviates renal fibrosis by restoring NAD+ biosynthesis in vivo and in vitro.
Gao L, Huang X, Deng R, Wu S, Peng Y, Xiong G, Lu J, Liu X
Aging 2023 Dec 28;16(1):106-128
Aging 2023 Dec 28;16(1):106-128
NAMPT mediates PDGF-induced pulmonary arterial smooth muscle cell proliferation by TLR4/NF-κB/PLK4 signaling pathway.
Li D, Chen Y, Wang Y, Liu J, Chai L, Zhang Q, Qiu Y, Chen H, Shen N, Shi X, Li M
European journal of pharmacology 2023 Dec 15;961:176151
European journal of pharmacology 2023 Dec 15;961:176151
Comparative Proteomics Reveals Prolonged Corneal Preservation Impaired Ocular Surface Immunity Accompanied by Fibrosis in Human Stroma.
Wu PS, Liu HY, Wong TH, Lin JT, Hu FR, Lin MH
Journal of proteome research 2023 Dec 1;22(12):3730-3741
Journal of proteome research 2023 Dec 1;22(12):3730-3741
High-Dosage NMN Promotes Ferroptosis to Suppress Lung Adenocarcinoma Growth through the NAM-Mediated SIRT1-AMPK-ACC Pathway.
Zhang M, Cui J, Chen H, Wang Y, Kuai X, Sun S, Tang Q, Zong F, Chen Q, Wu J, Wu S
Cancers 2023 Apr 23;15(9)
Cancers 2023 Apr 23;15(9)
Circular RNA triple functional domain promotes osteoarthritis' development by modulating the microRNA-136-5p/Nicotinamide phosphoribosyltransferase axis.
Yang J, Li Q, Wang T, Lv K
Bioengineered 2022 Mar;13(3):6070-6079
Bioengineered 2022 Mar;13(3):6070-6079
NAD(+) Anabolism Disturbance Causes Glomerular Mesangial Cell Injury in Diabetic Nephropathy.
Li X, Li Y, Li F, Chen Q, Zhao Z, Liu X, Zhang N, Li H
International journal of molecular sciences 2022 Mar 22;23(7)
International journal of molecular sciences 2022 Mar 22;23(7)
Glucose-6-phosphate dehydrogenase exerts antistress effects independently of its enzymatic activity.
Jin X, Li X, Li L, Zhong B, Hong Y, Niu J, Li B
The Journal of biological chemistry 2022 Dec;298(12):102587
The Journal of biological chemistry 2022 Dec;298(12):102587
Astrocyte-derived exosomal nicotinamide phosphoribosyltransferase (Nampt) ameliorates ischemic stroke injury by targeting AMPK/mTOR signaling to induce autophagy.
Deng Y, Duan R, Ding W, Gu Q, Liu M, Zhou J, Sun J, Zhu J
Cell death & disease 2022 Dec 20;13(12):1057
Cell death & disease 2022 Dec 20;13(12):1057
Inhibition of Pre-B Cell Colony Enhancing Factor Reduces Lung Injury in Rats Receiving Cardiopulmonary Bypass.
Lu C, Yang W, Zhou J, Zhang Z, Gong Y, Hu F, Yu W, Dong X
Drug design, development and therapy 2021;15:51-60
Drug design, development and therapy 2021;15:51-60
Impaired Nicotinamide Adenine Dinucleotide Biosynthesis in the Kidney of Chronic Kidney Disease.
Liu X, Luo D, Huang S, Liu S, Zhang B, Wang F, Lu J, Chen J, Li S
Frontiers in physiology 2021;12:723690
Frontiers in physiology 2021;12:723690
Nicotinamide improves NAD(+) levels to protect against acetaminophen-induced acute liver injury in mice.
Xu J, Zhang L, Jiang R, Hu K, Hu D, Liao C, Jiang S, Yang Y, Huang J, Tang L, Li L
Human & experimental toxicology 2021 Nov;40(11):1938-1946
Human & experimental toxicology 2021 Nov;40(11):1938-1946
Hyperglycemia-reduced NAD(+) biosynthesis impairs corneal epithelial wound healing in diabetic mice.
Li Y, Li J, Zhao C, Yang L, Qi X, Wang X, Zhou Q, Shi W
Metabolism: clinical and experimental 2021 Jan;114:154402
Metabolism: clinical and experimental 2021 Jan;114:154402
NAD(+) Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion.
Lv H, Lv G, Chen C, Zong Q, Jiang G, Ye D, Cui X, He Y, Xiang W, Han Q, Tang L, Yang W, Wang H
Cell metabolism 2021 Jan 5;33(1):110-127.e5
Cell metabolism 2021 Jan 5;33(1):110-127.e5
CD38 and MGluR1 as possible signaling molecules involved in epileptogenesis: A potential role for NAD(+) homeostasis.
Khodaverdian S, Dashtban-Moghadam E, Dabirmanesh B, Mirnajafi-Zadeh J, Taleb M, Khajeh K, Fathollahi Y
Brain research 2021 Aug 15;1765:147509
Brain research 2021 Aug 15;1765:147509
Nicotinamide Riboside Enhances Mitochondrial Proteostasis and Adult Neurogenesis through Activation of Mitochondrial Unfolded Protein Response Signaling in the Brain of ALS SOD1(G93A) Mice.
Zhou Q, Zhu L, Qiu W, Liu Y, Yang F, Chen W, Xu R
International journal of biological sciences 2020;16(2):284-297
International journal of biological sciences 2020;16(2):284-297
Trimetazidine Inhibits Renal Tubular Epithelial Cells to Mesenchymal Transition in Diabetic Rats via Upregulation of Sirt1.
Yang Y, Wang Y, He Z, Liu Y, Chen C, Wang Y, Wang DW, Wang H
Frontiers in pharmacology 2020;11:1136
Frontiers in pharmacology 2020;11:1136
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) with OT-82 induces DNA damage, cell death, and suppression of tumor growth in preclinical models of Ewing sarcoma.
Gibson AE, Yeung C, Issaq SH, Collins VJ, Gouzoulis M, Zhang Y, Ji J, Mendoza A, Heske CM
Oncogenesis 2020 Sep 10;9(9):80
Oncogenesis 2020 Sep 10;9(9):80
NAMPT and NAPRT, Key Enzymes in NAD Salvage Synthesis Pathway, Are of Negative Prognostic Value in Colorectal Cancer.
Li XQ, Lei J, Mao LH, Wang QL, Xu F, Ran T, Zhou ZH, He S
Frontiers in oncology 2019;9:736
Frontiers in oncology 2019;9:736
NAMPT overexpression alleviates alcohol-induced hepatic steatosis in mice.
Xiong X, Yu J, Fan R, Zhang C, Xu L, Sun X, Huang Y, Wang Q, Ruan HB, Qian X
PloS one 2019;14(2):e0212523
PloS one 2019;14(2):e0212523
Dietary Antioxidant Trans-Cinnamaldehyde Reduced Visfatin-Induced Breast Cancer Progression: In Vivo and In Vitro Study.
Chiang YF, Chen HY, Huang KC, Lin PH, Hsia SM
Antioxidants (Basel, Switzerland) 2019 Dec 6;8(12)
Antioxidants (Basel, Switzerland) 2019 Dec 6;8(12)
Corneal Denervation Causes Epithelial Apoptosis Through Inhibiting NAD+ Biosynthesis.
Li Y, Ma X, Li J, Yang L, Zhao X, Qi X, Zhang X, Zhou Q, Shi W
Investigative ophthalmology & visual science 2019 Aug 1;60(10):3538-3546
Investigative ophthalmology & visual science 2019 Aug 1;60(10):3538-3546
Exogenous H(2)S switches cardiac energy substrate metabolism by regulating SIRT3 expression in db/db mice.
Sun Y, Tian Z, Liu N, Zhang L, Gao Z, Sun X, Yu M, Wu J, Yang F, Zhao Y, Ren H, Chen H, Zhao D, Wang Y, Dong S, Xu C, Lu F, Zhang W
Journal of molecular medicine (Berlin, Germany) 2018 Apr;96(3-4):281-299
Journal of molecular medicine (Berlin, Germany) 2018 Apr;96(3-4):281-299
NMNAT3 is involved in the protective effect of SIRT3 in Ang II-induced cardiac hypertrophy.
Yue Z, Ma Y, You J, Li Z, Ding Y, He P, Lu X, Jiang J, Chen S, Liu P
Experimental cell research 2016 Oct 1;347(2):261-73
Experimental cell research 2016 Oct 1;347(2):261-73
Effect of curcumin on visfatin and zinc-α2-glycoprotein in a rat model of non-alcoholic fatty liver disease.
Li C, Li J, Chen Y, Zhong X, Kang M
Acta cirurgica brasileira 2016 Nov;31(11):706-713
Acta cirurgica brasileira 2016 Nov;31(11):706-713
Hepatic NAD(+) deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing.
Zhou CC, Yang X, Hua X, Liu J, Fan MB, Li GQ, Song J, Xu TY, Li ZY, Guan YF, Wang P, Miao CY
British journal of pharmacology 2016 Aug;173(15):2352-68
British journal of pharmacology 2016 Aug;173(15):2352-68
Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage.
Tummala KS, Gomes AL, Yilmaz M, Graña O, Bakiri L, Ruppen I, Ximénez-Embún P, Sheshappanavar V, Rodriguez-Justo M, Pisano DG, Wagner EF, Djouder N
Cancer cell 2014 Dec 8;26(6):826-839
Cancer cell 2014 Dec 8;26(6):826-839
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse heart tissue were subjected to SDS PAGE followed by western blot with 11776-1-AP(NAMPT antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-NAMPT (IP:11776-1-AP, 3ug; Detection:11776-1-AP 1:1000) with mouse heart tissue lysate 4000ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Visfatin antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Visfatin. This antibody recognizes human,mouse,rat, zebrafish antigen. The Visfatin antibody has been validated for the following applications: ELISA, IHC, WB, IP analysis.