66385-1-Ig

antibody from Proteintech Group

Targeting: NAMPT PBEF, PBEF1

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

66385-1-Ig

Provider

Proteintech Group

Product name

NAMPT/PBEF antibody

Antibody type

Monoclonal

Description

KD/KO validated NAMPT/PBEF antibody (Cat. #66385-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

3D4D8

Vial size

20ul, 150ul

References

Submitted references

Integrated RNA-seq and scRNA-seq to explore the biological mechanisms of mitophagy-related genes in ulcerative colitis.

Ma J, Xu R, Liu Y, Shao J, Xu J, Qi Y
PloS one 2026;21(4):e0346974

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GD2-directed NAMPT inhibition using antibody-drug conjugates in neuroblastoma.

Liu J, Cheng Q, Huangfu S, Zhang Y, Jiang B, Zhang Y, Chen H
European journal of medicinal chemistry 2026 Apr 5;307:118691

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Adipocytes Promote Cisplatin Resistance through Secreting A1BG and Regulating NAMPT/PARP1 Axis-Mediated DNA Repair in Osteosarcoma.

Liang Y, Li Z, Tang L, Pan Z, Fei X, Tan C, He A, Yang Q, Cheng D
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e02926

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Nicotine Reprograms Aging-Related Metabolism and Protects Against Motor Decline in Mice.

Jia S, Jing X, Wang R, Su M, Wang P, Feng Y, Ren X, Tu L, Wei P, Lu Z, Jia Y, Hong F, Mo Z, Zou J, Huang K, Yan C, Zou Q, Wang L, Zhong G, Zeng Z, Yu Q, Su W, Yang X, Pan F, Wang J, Wang L, Kang L, Kenny PJ, Chen Z, Liu XA
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(40):e15311

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Mitochondrial NAD(+) deficiency in vascular smooth muscle impairs collagen III turnover to trigger thoracic and abdominal aortic aneurysm.

Zhang J, Tang Y, Zhang S, Xie Z, Ma W, Liu S, Fang Y, Zheng S, Huang C, Yan G, Abudupataer M, Xin Y, Zhu J, Han W, Wang W, Shen F, Lai H, Liu Y, Ye D, Yu FX, Xu Y, Pan C, Wang C, Zhu K, Zhang W
Nature cardiovascular research 2025 Mar;4(3):275-292

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Activation of the impaired NAMPT/SIRT7/SOD2 axis restores alveolar progenitor cell homeostasis in idiopathic pulmonary fibrosis and reverses pulmonary fibrosis in mice.

Zhang X, Liu X, Qiao Y, Rabata A, Liu N, Yao C, Parimon T, Chen D, Chen P, Stripp B, Gardell SJ, Jiang D, Noble PW, Liang J
bioRxiv : the preprint server for biology 2025 Jul 3;

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The mitochondrial NAD transporter SLC25A51 is a modulator of beta cell senescence and type 2 diabetes.

Kong BS, L'Yi S, Ramirez-Hernandez EG, Hong S, Weidenspointner R, Song S, Caserta C, Cho YM, Kory N
bioRxiv : the preprint server for biology 2025 Apr 11;

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NAMPT/NAD(+)/PARP1 Pathway Regulates CFA-Induced Inflammatory Pain via NF-κB Signaling in Rodents.

Dai Y, Lin J, Chen X, Ren J, Wu C, Shen H, Li X, Yu J, Jiang B, Yu L
Advanced biology 2024 May;8(5):e2400028

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Design of FK866-Based Degraders for Blocking the Nonenzymatic Functions of Nicotinamide Phosphoribosyltransferase.

Lu T, Chen F, Yao J, Bu Z, Kyani A, Liang B, Chen S, Zheng Y, Liang H, Neamati N, Liu Y
Journal of medicinal chemistry 2024 May 23;67(10):8099-8121

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NAMPT-targeting PROTAC and nicotinic acid co-administration elicit safe and robust anti-tumor efficacy in NAPRT-deficient pan-cancers.

Zhu X, Li Y, Liu H, Wang Y, Sun R, Jiang Z, Hou C, Hou X, Huang S, Zhang H, Wang H, Jiang B, Yang X, Xu B, Fan G
Cell chemical biology 2024 Jun 20;31(6):1203-1218.e17

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Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer.

Jiang Y, Wang Y, Chen G, Sun F, Wu Q, Huang Q, Zeng D, Qiu W, Wang J, Yao Z, Liang B, Li S, Wu J, Huang N, Wang Y, Chen J, Zhai X, Huang L, Xu B, Yamamoto M, Tsukamoto T, Nomura S, Liao W, Shi M
Cell metabolism 2024 Aug 6;36(8):1806-1822.e11

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Mannan-binding lectin inhibits oxidative stress-induced senescence via the NAD+/Sirt1 pathway.

Lei Y, Meng J, Shi H, Shi C, Li C, Yang Z, Zhang W, Zuo D, Wang F, Wang M
International immunopharmacology 2024 Aug 20;137:112468

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Regulation of NAD(+)/NADH Redox Involves the Protective Effects of Ginsenoside Rb1 against Oxygen-Glucose Deprivation/Reoxygenation-Induced Astrocyte Lesions.

Liu Y, Wang X, Xie J, Tang M
International journal of molecular sciences 2023 Nov 7;24(22)

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Addressing the Enzyme-independent tumor-promoting function of NAMPT via PROTAC-mediated degradation.

Zhu X, Liu H, Chen L, Wu C, Liu X, Cang Y, Jiang B, Yang X, Fan G
Cell chemical biology 2022 Nov 17;29(11):1616-1629.e12

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NAD(+) supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells.

Wang Y, Wang F, Wang L, Qiu S, Yao Y, Yan C, Xiong X, Chen X, Ji Q, Cao J, Gao G, Li D, Zhang L, Guo Z, Wang R, Wang H, Fan G
Cell reports 2021 Aug 10;36(6):109516

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Nicotinamide phosphoribosyl transferase regulates cell growth via the Sirt1/P53 signaling pathway and is a prognosis marker in colorectal cancer.

Pan JH, Zhou H, Zhu SB, Huang JL, Zhao XX, Ding H, Qin L, Pan YL
Journal of cellular physiology 2019 Apr;234(4):4385-4395