13082-1-AP

antibody from Proteintech Group

Targeting: IL17A CTLA8, IL-17, IL-17A, IL17

Provider product page for 13082-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [44]
Comments [0]
Validations
Western blot [1]
Immunoprecipitation [1]
Immunohistochemistry [1]

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Product number: 13082-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#13082-1-AP, RRID:AB_10644322
Product name: IL-17 antibody
Antibody type: Polyclonal
Description: IL-17 antibody (Cat. #13082-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

IL17A protein structure - 13082-1-AP shown in red.

Submitted references Successful treatment with guselkumab of anti-p200 pemphigoid associated with plaque psoriasis.

Kitayama S, Makino T, Kataoka K, Mori S, Takemoto K, Furukawa F, Torai R, Hayashi M, Mizawa M, Ishii N, Hashimoto T, Shimizu T
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 2024 May;22(5):713-715

Porphyromonas gingivalis as a promotor in the development of the alcoholic liver disease via ferroptosis.

Yao C, Lu L, Lan D, Zhu X, Li X, Gao Y, Zhou Y, Wang Y, Xu Y, Qi S
Microbes and infection 2024 Mar-Apr;26(3):105250

Hepatocyte growth factor is protective in early stage but bone-destructive in late stage of experimental periodontitis.

Zhao X, Liu W, Wu Z, He X, Tang Y, He Q, Lin C, Chen Y, Luo G, Yu T, Wang X
Journal of periodontal research 2024 Jun;59(3):565-575

Multi-omics approaches for the understanding of therapeutic mechanism for Huang-Qi-Long-Dan Granule against ischemic stroke.

Wu C, Wu C, Peng L, Wu M, Li Z, Chen J
Pharmacological research 2024 Jul;205:107229

SLAMF3 promotes Th17 differentiation and is reversed by iguratimod through JAK1/STAT3 pathway in primary Sjögren's syndrome.

Hu P, Cai J, Yang C, Xu L, Ma S, Song H, Yang P
International immunopharmacology 2024 Jan 5;126:111282

L.acidophilus participates in intestinal inflammation induced by PM(2.5) through affecting the Treg/Th17 balance.

Xu J, Wang J, He Y, Chen R, Meng Q
Environmental pollution (Barking, Essex : 1987) 2024 Jan 15;341:122977

Sodium-glucose co-transporter 2 inhibitor canagliflozin modulates myocardial metabolism and inflammation in a swine model for chronic myocardial ischemia.

Harris DD, Sabe SA, Xu CM, Sabra M, Broadwin M, Malhotra A, Li JW, Abid MR, Sellke FW
Surgery 2024 Feb;175(2):265-270

Liver metastasis affects progression pattern during immune checkpoint inhibitors monotherapy in gastric cancer.

Motoo I, Ando T, Hamashima T, Kajiura S, Sakumura M, Ueda Y, Murayama A, Ogawa K, Tsukada K, Ueda A, Suzuki N, Nakada N, Nakashima K, Hosokawa A, Yasuda I
Frontiers in oncology 2023;13:1193533

PCSK9 inhibition ameliorates experimental autoimmune myocarditis by reducing Th17 cell differentiation through LDLR/STAT-3/ROR-γt pathway.

Yu M, Tang W, Liang W, Xie B, Gao R, Ding P, Gu X, Wang M, Wen S, Sun P
International immunopharmacology 2023 Nov;124(Pt B):110962

Staphylococcus warneri strain XSB102 exacerbates psoriasis and promotes keratinocyte proliferation in imiquimod-induced psoriasis-like dermatitis mice.

Si W, Li M, Wang K, Li J, Xu M, Zhou X, Bai J, Qu Z, Song G, Wu X, Guo Y, Hu H, Fu D, Yang Z, Wu M, Yan D, Song X, Tian Z
Archives of microbiology 2023 Nov 22;206(1):3

Rat tight junction proteins are disrupted after subchronic exposure to okadaic acid.

Huang L, Liu B, Yu XW, Pan GQ, Xu JY, Yan D, Wang YL, Guo QN
Environmental science and pollution research international 2023 May;30(22):62201-62212

SMURF1 inhibits the Th17 and Th17.1 polarization and improves the Treg/Th17 imbalance in systemic lupus erythematosus through the ubiquitination of RORγt.

Zhong W, Feng L, Tian W, Qu H, Xu H, Ning K, Liu L, Liu W, Gong X, Chen H
Molecular immunology 2023 May;157:186-194

Heparanase Contributes to Psoriatic Lesions Through Crosstalk with IL-17 Pathway.

Zhu C, Ren Y, Yao H, Feng B, Liu L, Zheng M
Indian journal of dermatology 2023 Jan-Feb;68(1):59-66

Porphyromonas gingivalis is a risk factor for the development of nonalcoholic fatty liver disease via ferroptosis.

Yao C, Lan D, Li X, Wang Y, Qi S, Liu Y
Microbes and infection 2023 Jan-Feb;25(1-2):105040

Loganin reduces neuroinflammation and promotes functional recovery after spinal cord injury through inhibiting NF-κB/NLRP3 signalling.

Huang X, Chen X, Li Q, Ni BH, Wang W
Toxicon : official journal of the International Society on Toxinology 2023 Aug 15;232:107202

Identification of a novel immune gene panel in tongue squamous cell carcinoma.

Sun J, Guo F, Tang Q, Chen G, Peng J, Shen Y, Zhang J, Hu J, Yang C
American journal of translational research 2022;14(5):2801-2824

SGLT2 inhibitor, canagliflozin, ameliorates cardiac inflammation in experimental autoimmune myocarditis.

Long Q, Li L, Yang H, Lu Y, Yang H, Zhu Y, Tang Y, Liu C, Yuan J
International immunopharmacology 2022 Sep;110:109024

The role of proteoglycan form of DMP1 in cranial repair.

Liu Y, Niu P, Zhou M, Xue H
BMC molecular and cell biology 2022 Sep 30;23(1):43

Discovery of Orally Available Retinoic Acid Receptor-Related Orphan Receptor γ-t/Dihydroorotate Dehydrogenase Dual Inhibitors for the Treatment of Refractory Inflammatory Bowel Disease.

Chen JA, Ma H, Liu Z, Tian J, Lu S, Fang W, Ze S, Lu W, Xie Q, Huang J, Wang Y
Journal of medicinal chemistry 2022 Jan 13;65(1):592-615

Human breast milk-derived exosomes through inhibiting AT II cell apoptosis to prevent bronchopulmonary dysplasia in rat lung.

Zhou Y, Liu Y, Xu G, Liu L, Li H, Li Y, Yin J, Wang X, Yu Z
Journal of cellular and molecular medicine 2022 Aug;26(15):4169-4182

SPRC Suppresses Experimental Periodontitis by Modulating Th17/Treg Imbalance.

Peng Q, Zhao B, Lin J, Liu H, Zhou R, Lan D, Yao C, Cong S, Tao S, Zhu Y, Wang R, Qi S
Frontiers in bioengineering and biotechnology 2021;9:737334

Autoimmune Hepatitis with Elevated Serum IgG4 Levels Have a High Prevalence of Cirrhosis at Diagnosis.

Xue M, Shen Y, Fan X, Shen M, Yang L
Canadian journal of gastroenterology & hepatology 2021;2021:6692511

IL-17 is expressed on beta and alpha cells of donors with type 1 and type 2 diabetes.

Rajendran S, Quesada-Masachs E, Zilberman S, Graef M, Kiosses WB, Chu T, Benkahla MA, Lee JM, von Herrath M
Journal of autoimmunity 2021 Sep;123:102708

Maiwei Yangfei decoction prevents bleomycin-induced pulmonary fibrosis in mice.

Xu Y, Peng W, Han D, Feng F, Wang Z, Gu C, Zhou X, Wu Q
Experimental and therapeutic medicine 2021 Nov;22(5):1306

Effects of Qing Chang Suppository Powder and its Ingredients on IL-17 Signal Pathway in HT-29 Cells and DSS-induced Mice.

Zhou G, Kong WS, Li ZC, Xie RF, Yu TY, Zhou X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jul;87:153573

The Prognostic Significance of Peritumoral Lymphocytes' Band-like Structure in Type II Endometrial Cancer.

Shimizu Y, Suzuki S, Ukai M, Hattori S, Yoshikawa N, Kajiyama H
Anticancer research 2021 Jan;41(1):249-258

The role of IP-10 and its receptor CXCR3 in early pregnancy.

Jiang Y, Huang F, Chai X, Yuan W, Ding H, Wu X
Molecular immunology 2021 Dec;140:59-69

Interleukin-17 is a potential player and treatment target in severe chronic spontaneous urticaria.

Sabag DA, Matanes L, Bejar J, Sheffer H, Barzilai A, Church MK, Toubi E, Maurer M, Vadasz Z
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2020 Jul;50(7):799-804

IL-17A increases MHC class I expression and promotes T cell activation in papillary thyroid cancer patients with coexistent Hashimoto's thyroiditis.

Han LT, Hu JQ, Ma B, Wen D, Zhang TT, Lu ZW, Wei WJ, Wang YL, Wang Y, Liao T, Ji QH
Diagnostic pathology 2019 Jun 4;14(1):52

Histone Acetyltransferase Mof Affects the Progression of DSS-Induced Colitis.

Yang Y, Guan J, Shaikh AS, Liang Y, Sun L, Wang M, Li D, Qiu C, Li X
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;47(5):2159-2169

Irie K, Tomofuji T, Ekuni D, Fukuhara D, Uchida Y, Kataoka K, Kobayashi S, Kikuchi T, Mitani A, Shimazaki Y, Morita M
Archives of oral biology 2018 Mar;87:72-78

IL-17 Promotes Scar Formation by Inducing Macrophage Infiltration.

Zhang J, Qiao Q, Liu M, He T, Shi J, Bai X, Zhang Y, Li Y, Cai W, Han S, Guan H, Hu D
The American journal of pathology 2018 Jul;188(7):1693-1702

MBD2 Regulates Th17 Cell Differentiation and Experimental Severe Asthma by Affecting IRF4 Expression.

Jia A, Wang Y, Sun W, Xiao B, Wei Y, Qiu L, Mu L, Xu L, Li J, Zhang X, Liu D, Peng C, Zhang D, Xiang X
Mediators of inflammation 2017;2017:6249685

Myeloid dendritic cells stimulated by thymic stromal lymphopoietin promote Th2 immune responses and the pathogenesis of oral lichen planus.

Yamauchi M, Moriyama M, Hayashida JN, Maehara T, Ishiguro N, Kubota K, Furukawa S, Ohta M, Sakamoto M, Tanaka A, Nakamura S
PloS one 2017;12(3):e0173017

Comparison of the roles of house dust mite allergens, ovalbumin and lipopolysaccharides in the sensitization of mice to establish a model of severe neutrophilic asthma.

Jia A, Wang Y, Sun W, Xiao B, Mu L, Wei Y, Xu L, Peng C, Zhang D, Shen H, Xiang X
Experimental and therapeutic medicine 2017 Sep;14(3):2126-2134

Interleukin-17A Plays the Same Role on Mice Acute Lung Injury Respectively Induced by Lipopolysaccharide and Paraquat.

Song HW, Yang C, Liu W, Liu XW, Liu Z, Gao F
Inflammation 2017 Oct;40(5):1509-1519

Disruption of Tumor Necrosis Factor Receptor-Associated Factor 5 Exacerbates Murine Experimental Colitis via Regulating T Helper Cell-Mediated Inflammation.

Shang J, Li L, Wang X, Pan H, Liu S, He R, Li J, Zhao Q
Mediators of inflammation 2016;2016:9453745

p38 mitogen-activated protein kinase inhibition modulates nucleus pulposus cell apoptosis in spontaneous resorption of herniated intervertebral discs: An experimental study in rats.

Zhu Y, Liu JT, Yang LY, Du WP, Li XC, Qian X, Yu PF, Liu JW, Jiang H
Molecular medicine reports 2016 May;13(5):4001-6

Effects of Bacillus subtilis on Epithelial Tight Junctions of Mice with Inflammatory Bowel Disease.

Gong Y, Li H, Li Y
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2016 Feb;36(2):75-85

Upregulated Expression of microRNA-16 Correlates with Th17/Treg Cell Imbalance in Patients with Rheumatoid Arthritis.

Wu YH, Liu W, Xue B, Zhang L, Liu XY, Liu B, Wang Y, Cai Y, Duan R
DNA and cell biology 2016 Dec;35(12):853-860

Interleukin-17 retinotoxicity is prevented by gene transfer of a soluble interleukin-17 receptor acting as a cytokine blocker: implications for age-related macular degeneration.

Ardeljan D, Wang Y, Park S, Shen D, Chu XK, Yu CR, Abu-Asab M, Tuo J, Eberhart CG, Olsen TW, Mullins RF, White G, Wadsworth S, Scaria A, Chan CC
PloS one 2014;9(4):e95900

Prevalence of Th17 and Treg cells in gastric cancer patients and its correlation with clinical parameters.

Li Q, Li Q, Chen J, Liu Y, Zhao X, Tan B, Ai J, Zhang Z, Song J, Shan B
Oncology reports 2013 Sep;30(3):1215-22

Reduced Il17a expression distinguishes a Ly6c(lo)MHCII(hi) macrophage population promoting wound healing.

Rodero MP, Hodgson SS, Hollier B, Combadiere C, Khosrotehrani K
The Journal of investigative dermatology 2013 Mar;133(3):783-792

Implications of Th1 and Th17 cells in pathogenesis of oral lichen planus.

Xie S, Ding L, Xiong Z, Zhu S
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2012 Jun;32(3):451-457

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: U-937 cells were subjected to SDS PAGE followed by western blot with 13082-1-AP(IL17A antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: IP Result of anti-IL17A (IP:13082-1-AP, 3ug; Detection:13082-1-AP 1:300) with U-937 cells lysate 6500ug.
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The IL-17 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human IL-17. This antibody recognizes human, mouse antigen. The IL-17 antibody has been validated for the following applications: ELISA, IHC, IP, WB analysis.
Appendix: 13082-1-AP.pdf

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