orb48920

antibody from Biorbyt
Targeting: IL17A CTLA8, IL-17, IL-17A, IL17
Provider product page for orb48920
Western blot

Antibody data

Product number
orb48920 - Provider product page
Provider
Biorbyt
Product name
IL17A antibody
Antibody type
Polyclonal
Description
Rabbit polyclonal to IL17A.IL-17A is a cystine-linked homodimeric pro-inflammatory cytokine produced by Th17 cells, a distinct CD4+ T cell lineage. IL-17A stimulates the production of the pro-inflammatory cytokines IL-1beta, TNF-alpha, and IL-6. IL-17A also induces production of the neutrophil chemoattractants IL-8, CXCL1, and CXCL6 thereby bridging adaptive and innate immunity. IL-17A is intimately involved in mucosal immunity against bacterial infections and has a putative role in some autoimmune disorders. IL-17A effects appear to be exerted primarily through binding to the IL-17RA. IL-17A binding induces production of cytokines, chemokines and other proteins through activation of the Erk1/2 MAP kinase, PI3K/Akt, p38, and NF-kB pathways.
Reactivity
Human
Conjugate
Unconjugated
Isotype
IgG
Vial size
50 ul
Storage
Store at -20°C. Avoid freeze / thaw cycles.
IL17A protein structure - orb48920 shown in red.