Antibody data
- Antibody Data
- Antigen structure
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- Product number
- orb48920 - Provider product page
- Provider
- Biorbyt
- Product name
- IL17A antibody
- Antibody type
- Polyclonal
- Description
- Rabbit polyclonal to IL17A.IL-17A is a cystine-linked homodimeric pro-inflammatory cytokine produced by Th17 cells, a distinct CD4+ T cell lineage. IL-17A stimulates the production of the pro-inflammatory cytokines IL-1beta, TNF-alpha, and IL-6. IL-17A also induces production of the neutrophil chemoattractants IL-8, CXCL1, and CXCL6 thereby bridging adaptive and innate immunity. IL-17A is intimately involved in mucosal immunity against bacterial infections and has a putative role in some autoimmune disorders. IL-17A effects appear to be exerted primarily through binding to the IL-17RA. IL-17A binding induces production of cytokines, chemokines and other proteins through activation of the Erk1/2 MAP kinase, PI3K/Akt, p38, and NF-kB pathways.
- Reactivity
- Human
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 50 ul
- Storage
- Store at -20°C. Avoid freeze / thaw cycles.
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