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Blocking/NeutralizingAntibody data
- Antibody Data
- Antigen structure
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- Validations
- Blocking/Neutralizing [1]
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- Product number
- MAB5848 - Provider product page
- Provider
- R&D Systems
- Product name
- Canine IL-17 Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects canine IL-17 in direct ELISAs. In direct ELISAs, approximately 25% cross-reactivity with recombinant human (rh) IL-17A is observed and no cross-reactivity with rhIL-17F or recombinant mouse IL-17A is observed.
- Reactivity
- Canine
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
NP_001159350- Isotype
- IgG
- Antibody clone number
- 665909
- Vial size
- 500 ug
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
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Supportive validation
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- R&D Systems (provider)
- Main image
- Experimental details
- IL-6 Secretion Induced by IL-17 and Neutralization by Canine IL-17 Antibody. Recombinant Canine IL-17 (Catalog # 5848-CL) induces IL-6 secretion in the NIH-3T3 mouse embryonic fibroblast cell line in a dose-dependent manner (orange line). IL-6 Secretion elicited by Recombinant Canine IL-17 (5 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-Canine IL-17 Monoclonal Antibody (Catalog # MAB5848). The ND50 is typically 5-30 ng/mL.
