66148-1-Ig

antibody from Proteintech Group

Targeting: IL17A CTLA8, IL-17, IL-17A, IL17

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

66148-1-Ig

Provider

Proteintech Group

Product name

IL-17 antibody

Antibody type

Monoclonal

Description

IL-17 antibody (Cat. #66148-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, WB, ELISA.

Reactivity

Human, Mouse

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

1B3D5

Vial size

20ul, 150ul

References

Submitted references

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Follicular cytokine profiles and granulosa cell integrity across ovarian response during in vitro fertilisation.

Korkmaz O, Karabulut S, Macit P
Tissue & cell 2026 Jun;100:103370

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Immunomodulatory effects of bacterial lysates on the IL-17 signaling pathway in an asthma mouse model.

Gao M, Wang X, Yin L, Wei X, Li F
The Journal of asthma : official journal of the Association for the Care of Asthma 2026 Feb;63(2):159-168

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Extracts of Portulaca oleracea and Patrinia scabiosaefolia relieve ultraviolet B-induced skin injury in solar dermatitis mice via inhibiting IL-17/CCL2 pathway and oxidative stress.

Li B, Yang J, Wang Z, He M, Chen X, Chen Y, Shen B, Chen J, Yang C, Li T, Lai C, Gao Y, Cai H
International journal of medical sciences 2025;22(4):856-872

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Identification of PRKCQ-AS1 as a Keratinocyte-Derived Exosomal lncRNA That Promotes Th17 Differentiation and IL-17 secretion in Psoriasis Through Bioinformatics, Machine Learning Algorithms, and Cell Experiments.

Gao P, Gao X, Lin L, Zhang M, Luo D, Chen C, Li Y, He Y, Liu X, Shi C, Yang R
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Atorvastatin Alleviates Sepsis-Induced Cardiomyopathy by Targeting the METTL3/IGF2BP1/CXCL2 Pathway.

Zhang L, Yin Y, Zheng L, Wang Y, Zhao J, Mu F, Jin F, Gong R, Wang J
Journal of inflammation research 2025;18:14609-14628

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Recombinant Antithrombin Alleviated Pulmonary Injury and Inflammation in LPS-Induced ARDS by Inhibiting IL17a/NF-κB Signaling.

Yang C, Fu C, Wang M, Zheng J, Gao Y, Zhu H, Li H, Li D, Guo L, Yu B, Dai Q
ImmunoTargets and therapy 2025;14:433-449

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Melatonin Ameliorates Circadian Disruption-Associated Dry Eye via Modulation of BMAL1-REV-ERBα-IL-17 Axis and Ocular Surface Microbiota Homeostasis.

Wang B, Zeng H, Yang X, Zuo X, Liang L, Zhang R, Deng W, Ju R, Wang X, Yuan J
Journal of pineal research 2025 Sep;77(5):e70076

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Cu-DHM nanozymes treat flap ischemia-reperfusion injury by amplifying immune modulation in a cascade manner and inhibiting cell apoptosis.

Zhao X, Zhang S, Wang M, Li Q, Wei X, Chen XL, Wang X
Bioactive materials 2025 Sep;51:720-739

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MiR-155-5p facilitates acute lung injury progression via Th17 cells through the ETS-1/STAT3 pathway.

Wang M, Jin XE, Xue CM, Liao QB, Pu YF, Liu GQ, Zhuang ZW, Wang YX, Ding Q, Yang XJ
Gene 2025 Sep 5;963:149605

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PPARγ accelerates OSCC progression via Th17 polarization and CEBPA/IL-17C signaling.

Wang Y, Liang J, Zhang S, Zhang Y, Cheng F, Ji N, Li J, Chen Q, Zeng X
Journal of cancer research and clinical oncology 2025 Sep 16;151(10):259

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Chronic Waterborne Exposure to Polystyrene Microplastics Induces Kupffer Cell Polarization Imbalance and Hepatic Lipid Accumulation.

Li T, Yao Z, Huang Y, Li R, Zhang L, Chen R, Gu W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Sep 15;39(17):e70980

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Unraveling Laser-Induced peripheral Pain: Proteomic profiling and electrophysiological Dynamics in mice.

Guo Y, Ren X, Li H, Tian R, Xu S, Cao Z, Gu X, Shang M, Wang H, Xing J
Brain research 2025 Sep 15;1863:149743

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Corynebacterium striatum drives neutrophilic asthma via IL-17 signaling activation.

Yu X, Li X, Wang Y, Yu X, Guo X, Wang C, Wang F
International immunopharmacology 2025 Oct 10;163:115255

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Rhein-Integrated Extracellular Matrix-Mimetic Hydrogel for Accelerated Healing of Infected Wounds within 7 Days.

Tang L, Cao J, Li N, Yu H, Zhang R, Qi S, Li Z, Li RW, Zhang Y
ACS applied materials & interfaces 2025 Oct 1;17(39):54563-54578

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Saccharomyces boulardii Alleviates Ovalbumin-Induced Pyroptosis Through Cyba and IL-17 Signaling Pathway.

Chen Z, Hu L, Yang Y, Wang Y, Li Y, Su J, Wang G, Gong S
Molecular nutrition & food research 2025 Nov;69(21):e70194

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Significance of integrated clinical and proteomic characteristics analysis for pathogenesis and management of Crohn's disease with concomitant psoriasis.

Zhang H, He C, Fan X, Song Q, Lin C, Zhou P, Song Y, Li N, Shi Y, Lin Z, Chen Q, Zheng Y, Wang S, Li Z, Zhang W, Liu Q, Qing Q, Sun Y, Huang B, Li M
EBioMedicine 2025 Nov;121:105981

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Microneedle system carrying Momordin Ic-loaded ROS-responsive hydrogel ameliorates psoriasis via targeted anti-inflammatory and reactive oxygen species (ROS)-scavenging mechanisms.

Wang C, Zhou L, Han Z, He L, Yuan J, Zhang J, Zhu Q, Wang S
International journal of pharmaceutics 2025 May 15;676:125530

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Engineering a halloysite nanotube-enhanced hydrogel 3D skin model for modulated inflammation and accelerated wound healing.

Xu R, Fu X, Lun L, Jiang W, Situ X, Huang X, Xiong Y, Liu C, Wang F
Bioactive materials 2025 Mar;45:148-161

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Potential therapeutic effect of dimethyl fumarate on Treg/Th17 cell imbalance in biliary atresia.

Liu M, Zhu Y, Meng W, Zhang C, Chen Y, Shi Q, Song S, Zheng S, Liu Y, Zhou Y, Chen G
Clinical immunology (Orlando, Fla.) 2025 Mar;272:110439

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Nervonic acid mitigates IMQ-triggered psoriasis in mice via inhibiting Th17/γδT17 cell invasion and modulating the gut microbiota.

Yang Z, Geng X, Zhang S, Gao J, Ji F, Han Y, Cui Z, Wang X, Guo S, Yan D, Zhao T, Ren F, Li X, Dong J, Tian Z, Yin Z, Song X
Journal of leukocyte biology 2025 Jun 4;117(6)

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KRAS regulates IL-17 signal activity by affect the metastasis of osteosarcoma via an IL-17A-dependent manner.

Bao X, Zhang N, Wang C, Liu S, Fan A, Zheng F, Yang C
JBMR plus 2025 Jul;9(7):ziaf056

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Discovery of STING antagonists targeting cGAS-STING pathway to alleviate IMQ-induced psoriasis-like dermatitis.

Zhang Z, Wei X, Huang Q, Shi Z, Chen X, Wu J, Wang X, Li J, Gou L, Yang J
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2025 Jul 1;210:107091

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IL-17A's role in exacerbating radiation-induced lung injury: Autophagy impairment via the PP2A-mTOR pathway.

Liu L, Yi G, Li X, Chen C, Chen K, He H, Li J, Cai F, Peng Y, Yang Z, Zhang X
Biochimica et biophysica acta. Molecular cell research 2025 Jan;1872(1):119864

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Integrating network pharmacology and transcriptomics to study the potential mechanism of Jingzhi Niuhuang Jiedu tablet in rats with accumulation of heat in the lungs and stomach.

Dai ZQ, Guo ZQ, Zhang T, Chu YF, Yan Y, Gao F, Li SL, Gu YH, Jiao JY, Lin YX, Zhao SW, Xu B, Lei HM
Journal of ethnopharmacology 2025 Jan 30;337(Pt 2):118890

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Exploring the potential anti-COPD ingredients and mechanisms of the Qingfei decoction based on UHPLC-HRMS, network pharmacology and transcriptomic analysis.

Zhang T, Guo Z, Ma T, Li S, Dai Z, Luo Y, Gao F, Zeng Q, Lu J, Wang J, Liu Y, Xu B, Lei H
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2025 Jan 15;1251:124420

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3-acetyl-11-keto-β-boswellic acid and chitosan-Ag nanoparticles for synergistic tumor-resident bacteria mediated prostate cancer therapy.

Zou B, Tian X, Gao R, Long H, Long Y, Liu B, Zhou Q
Materials today. Bio 2025 Dec;35:102374

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A Novel TLR4 Inhibitor DB03476 Rescued Renal Inflammation in Acute Kidney Injury Model.

Zhang YF, Ma YX, Wei SJ, Yang B, Ji YH, Qi ZX, Shi XY, Zhang LL, Fan XZ, Yang XJ
International journal of molecular sciences 2025 Dec 31;27(1)

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Antibiotic cocktail-induced changes in gut microbiota drive alteration of bile acid metabolism to restrain Th17 differentiation through the FXR-NLRP3 axis.

Shao-Yu Y, Niu D, Chen J, Li WY, Wang X, Meng QW, Song WJ, Yang YG, Wang H, Li RR, Li BY, Zhang LG, Hu CJ, Xu LF, Wang HH, Zhang L, Liang CZ, Du HX
Gut microbes 2025 Dec 31;17(1):2582944

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Th17 cells/IL-17A shape Pasteurella multocida serotype A infection in murine and rabbit models.

Liu X, Lu F, Zhang T, Li N, He F, Peng Y, Zhao G
Veterinary research 2025 Dec 16;56(1):229

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RPPH1 promotes the progression of High-Risk acute myeloid leukemia through NF-κB signaling and Th17 expression.

Wang M, Li W, Luo C, Cao Y, Lu Z, Zhu J, Xiang M, Liao P, Li J
Medical oncology (Northwood, London, England) 2025 Dec 1;43(1):30

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Hydroxychloroquine cures autoimmune myocarditis by inhibiting the innate immune system via the C-X-C motif chemokine ligand 16 and C-X-C motif receptor 6 axis between macrophages and T cells.

Xuan Y, Gao X, Wang J, Li H, Zhou Z, Liao M, Wen Z, Wang DW
British journal of pharmacology 2025 Aug;182(15):3649-3668

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Thalidomide mitigates Crohn's disease colitis by modulating gut microbiota, metabolites, and regulatory T cell immunity.

Tang CT, Wu Y, Tao Q, Zeng CY, Chen YX
Journal of pharmaceutical analysis 2025 Apr;15(4):101121

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NETs-CD44-IL-17A Feedback Loop Drives Th17-Mediated Inflammation in Behçet's Uveitis.

Wu Y, Ning K, Huang Z, Chen B, Chen J, Wen Y, Bu J, Hong H, Chen Q, Zhang Z, Jia R, Su W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(16):e2411524

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IL-17A deficiency inhibits lung cancer-induced osteoclastogenesis by promoting apoptosis of osteoclast precursor cells.

Wang H, Tang H, Yuan S, Liang C, Li Y, Zhu S, Chen K
PloS one 2024;19(2):e0299028

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Investigation of the therapeutic effects and mechanisms of Houpo Mahuang Decoction on a mouse model of chronic obstructive pulmonary disease.

Li S, Dai Z, Zhang T, Guo Z, Gao F, Cheng X, An J, Lin Y, Xiong X, Wang N, Jiang G, Xu B, Lei H
Frontiers in pharmacology 2024;15:1448069

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Salidroside may target PPARα to exert preventive and therapeutic activities on NASH.

Chu X, Liu S, Qu B, Xin Y, Lu L
Frontiers in pharmacology 2024;15:1433076

---

ROS-responsive drug-releasing injectable microgels for ameliorating myocardial infarction.

Wang S, Yao Y, Song L, Zhai Z, Li S, Wang Z, Shen L, Zhu Y, Liu W, Gao C
Biomaterials 2024 Jun;307:122534

---

Zhilong Huoxue Tongyu capsule alleviates myocardial fibrosis by improving endothelial cell dysfunction.

Bi T, Zhou Y, Mao L, Liang P, Liu J, Yang L, Ren G, Mazhar M, Shen H, Liu P, Spáčil R, Guo Q, Luo G, Yang S, Ren W
Journal of traditional and complementary medicine 2024 Jan;14(1):40-54

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A High MCT-Based Ketogenic Diet Suppresses Th1 and Th17 Responses to Ameliorate Experimental Autoimmune Encephalomyelitis in Mice by Inhibiting GSDMD and JAK2-STAT3/4 Pathways.

Zhang Q, Sun W, Wang Q, Zheng X, Zhang R, Zhang N
Molecular nutrition & food research 2024 Feb;68(3):e2300602

---

Tanshinone IIA, a component of the self-made Xiao-Yin decoction, ameliorates psoriasis by inhibiting IL-17/IL-23 and PTGS2/NF-κB/AP-1 pathways.

Fu L, Li M, Wang P, Chen L, Huang J, Zhang H
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 2024 Feb;30(2):e13577

---

RasGRP4 aggravates ischemia-reperfusion injury in diabetic kidneys by mediating communication between macrophages and T cells.

Zhang L, Wang Z, Wu Y, Zhang B, Wang Z, Chen S, Meng X, Yu P, Zhou S
JCI insight 2024 Dec 10;10(2)

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Immunocompatible elastomer with increased resistance to the foreign body response.

Zhou X, Lu Z, Cao W, Zhu Z, Chen Y, Ni Y, Liu Z, Jia F, Ye Y, Han H, Yao K, Liu W, Wang Y, Ji J, Zhang P
Nature communications 2024 Aug 30;15(1):7526

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Unbalanced Aryl Hydrocarbon Receptor Expression in Peripheral and Lesional T Cell Subsets of Atopic Dermatitis.

Hu YQ, Zhang JZ
Clinical, cosmetic and investigational dermatology 2023;16:3661-3671

---

Total alkaloids of Fritillaria unibracteata var. wabuensis bulbus ameliorate chronic asthma via the TRPV1/Ca(2+)/NFAT pathway.

Peng M, Li J, Zhou J, Zhang B, Liao J, Yang D, Wang Y, Yang Y, Li R, Tang X, Lu Q, Zhao Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Sep;118:154946

---

Ethanol extract of Herpetospermum caudigerum Wall ameliorates psoriasis-like skin inflammation and promotes degradation of keratinocyte-derived ICAM-1 and CXCL9.

Zhong Y, Zhang BW, Li JT, Zeng X, Pei JX, Zhang YM, Yang YX, Li FL, Deng Y, Zhao Q
Journal of integrative medicine 2023 Nov;21(6):584-592

---

A systematic pharmacology-based in vivo study to reveal the effective mechanism of Yupingfeng in asthma treatment.

Liu X, Yu Y, Wu Y, Luo A, Yang M, Li T, Li T, Mao B, Chen X, Fu J, Jiang H, Liu W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154783

---

GABA induced by sleep deprivation promotes the proliferation and migration of colon tumors through miR-223-3p endogenous pathway and exosome pathway.

Bao H, Peng Z, Cheng X, Jian C, Li X, Shi Y, Zhu W, Hu Y, Jiang M, Song J, Fang F, Chen J, Shu X
Journal of experimental & clinical cancer research : CR 2023 Dec 18;42(1):344

---

Fe-curcumin nanozyme-mediated immunosuppression and anti-inflammation in experimental autoimmune uveitis.

Jiang Z, Liang K, Gao X, Cao F, An G, Gui S, Tang W, Du L, Tao L, Wang X
Biomaterials research 2023 Dec 12;27(1):131

---

IL-17A Promotes Epithelial ADAM9 Expression in Cigarette Smoke-Related COPD.

Li D, Wang T, Ma Q, Zhou L, Le Y, Rao Y, Jin L, Pei Y, Cheng Y, Huang C, Gai X, Sun Y
International journal of chronic obstructive pulmonary disease 2022;17:2589-2602

---

Targeting A-kinase anchoring protein 12 phosphorylation in hepatic stellate cells regulates liver injury and fibrosis in mouse models.

Ramani K, Mavila N, Abeynayake A, Tomasi ML, Wang J, Matsuda M, Seki E
eLife 2022 Oct 4;11

---

Khasianine ameliorates psoriasis-like skin inflammation and represses TNF-α/NF-κB axis mediated transactivation of IL-17A and IL-33 in keratinocytes.

Yang Y, Zhang Y, Chen X, Su Z, Deng Y, Zhao Q
Journal of ethnopharmacology 2022 Jun 28;292:115124

---

IL-17A drives cognitive aging probably via inducing neuroinflammation and theta oscillation disruption in the hippocampus.

Li Y, Mao M, Zhu L, Sun Q, Tong J, Zhou Z
International immunopharmacology 2022 Jul;108:108898

---

(RS)-bambuterol and its enantiomers: Potential improvement of (R)-bambuterol in mice with colitis.

Deng L, Wang S, Guo H, Liu X, Zou X, Zhang R, Lin Y, Tan W
International immunopharmacology 2022 Feb;103:108501

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P-STAT3 and IL-17 in tumor tissues enhances the prognostic value of CEA and CA125 in patients with lung adenocarcinoma.

Chen XK, Gu CL, Fan JQ, Zhang XM
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109871

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MiR-let-7d-3p regulates IL-17 expression through targeting AKT1/mTOR signaling in CD4(+) T cells.

Wang J, Wang X, Wang L, Sun C, Xie C, Li Z
In vitro cellular & developmental biology. Animal 2020 Jan;56(1):67-74

---

Glucocorticoid-induced leucine zipper overexpression inhibits lipopolysaccharide-induced retinal inflammation in rats.

Gu R, Lei B, Shu Q, Li G, Xu G
Experimental eye research 2017 Dec;165:151-163

---

Upregulated Expression of microRNA-16 Correlates with Th17/Treg Cell Imbalance in Patients with Rheumatoid Arthritis.

Wu YH, Liu W, Xue B, Zhang L, Liu XY, Liu B, Wang Y, Cai Y, Duan R
DNA and cell biology 2016 Dec;35(12):853-860

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The IL-17 antibody from Proteintech is a mouse monoclonal antibody to a fusion protein of human IL-17. This antibody recognizes human antigen. The IL-17 antibody has been validated for the following applications: ELISA, WB analysis.

Appendix

66148-1-Ig.pdf

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