19374-1-AP

antibody from Proteintech Group

Targeting: USP10 KIAA0190, UBPO

Provider product page for 19374-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [36]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 19374-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#19374-1-AP, RRID:AB_10858617
Product name: USP10 antibody
Antibody type: Polyclonal
Description: USP10 antibody (Cat. #19374-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

USP10 protein structure - 19374-1-AP shown in red.

Submitted references Co-targeting MRPS7-23 synergistically enhances cisplatin efficacy to suppress nasopharyngeal carcinoma growth and metastasis.

Cao Z, Pan C, Liu Z, Quan Q, Li M, Huang Y, Liang C, Chen Y, Fan T, Chen P, Kai F, Zhu S, Li S, Su X, Wang F, Fu L, Zhang B
International journal of biological sciences 2026;22(2):970-994

DCLK1 drives malignant progression and chemoresistance of bladder cancer by deubiquitinating HDAC6.

Du A, Zhou Y, Deng X, Yuan D, Li K, Luo Y, Tan S, Dai X, Yu B, Jiang K, Tan X, Zhu J
Molecular cancer 2026 Jan 30;25(1)

MGMT upregulation mediates Temozolomide resistance conferred USP5 dependency.

Bhardwaj S, Sanjay, Sharma D, Taneja L, Yadav BK, Yadav AK
Scientific reports 2026 Jan 24;16(1):6118

USP10 regulates HIF2α stability by deubiquitinating HIF2α regardless of VHL status in kidney cancer.

Xu S, Huang W, Ma B, Li X
Translational andrology and urology 2026 Feb 28;15(2):55

Engineered Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Mitigate Liver Fibrosis by Delivering USP10 to Reprogram Macrophage Phenotype.

Tian S, Zhou X, Zheng L, Liu J, Zhang M, Ma S, Zheng X, Guo G, Ju R, Yang F, Liu Y, Li B, Hu Y, Xia E, Su R, Sun K, Cui L, Guo C, Zhou X, Wang J, Shang Y, Han Y
Biomaterials research 2025;29:0244

Perilipin 5 alleviates ferroptosis of cardiomyocytes by targeting USP10-p53-TfR proteasome-dependent degradation.

Zhao J, Shui J, Xu Q, Wang X, Shen Y, Liu C, Shen J
Frontiers in medicine 2025;12:1573230

USP10 protects against pressure overload-induced mitochondrial morphofunctional defects and pathological cardiac hypertrophy through stabilizing cytoplasmic Mfn2.

Li R, Gao F, Chen Y, Zhao J, Shi R, Li M, Zuo Z, Chang P, De D, Chen L, Fu F, Ding M
Redox biology 2025 Sep;85:103745

M6A-mediated uc003pes.1 stability regulates proliferation and migration of human coronary artery smooth muscle cells via scaffolding STAT1 and USP10.

Jiang R, Jia Q, Li C, He S, Zhou H, Ren M, Liang L, Jia E
Biochimica et biophysica acta. Molecular cell research 2025 Oct;1872(7):120023

Brusatol suppresses malignant progression of glioma via modulating the miR-574-5p/USP10/PLK1 axis.

Ma B, Wang L, Li J, Zhang B, Wang Y, Li N, Shen D, Han C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157142

Acacetin ameliorates pressure overload-induced cardiac remodeling by targeting USP10 and inhibiting maladaptive cardiomyocyte autophagy.

Ge G, Zhao W, Zhong Z, Huang Y, Hua Y, Chen K, Yu Y, Wu T, Lu Y, Yadav N, Zhang F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156588

USP10 promotes the progression and attenuates gemcitabine chemotherapy sensitivity via stabilizing PLK1 in PDAC.

Du X, Yu R, Yan C, Dong P, Wei C, Wang B, Zhang C, He Y, Wei Y, Han L, Sun J
Cell death & disease 2025 Jun 14;16(1):449

The deubiquitinase USP24 suppresses ferroptosis in triple-negative breast cancer by stabilizing DHODH protein.

Yang L, An X, Yang S, Lin X, Chen Z, Xue Q, Chen X, Wang Y, Yan D, Chen S, Fan Y, Tang D, Yu W, Liu J, Chen X
Cell death & disease 2025 Jul 26;16(1):564

ERβ/circAHNAK Axis Inhibits USP10-FMR1 Deubiquitination to Prevent m⁶A-Mediated ADAM17 Decay and Promote Angiogenesis in Clear Cell Renal Cell Carcinoma.

Xu C, Zhang S, Liu Y, Lv J, Cao Y, Chen Y, Sun H, Zhang B, Dai S, Li J, Li X, Shi B, Sun Q, Zhu M, Gu J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(48):e09654

Cholesterol-activated stress granules reduce the membrane localization of DRD2 and promote prolactinoma dopamine agonists resistance.

Peng Y, Yin H, Pei X, Zhang Y, Wang C, Zheng X, Liang H, Yang H, Li S
Acta neuropathologica communications 2025 Apr 25;13(1):84

PRDM16 suppresses pyroptosis to attenuate the progression of AKI caused by rhabdomyolysis via upregulation of USP10.

Han B, Zheng Q, Li H, Wang Y, Zhang D
Cellular and molecular life sciences : CMLS 2025 Apr 2;82(1):138

USP10 promotes pancreatic ductal adenocarcinoma progression by attenuating FOXC1 protein degradation to activate the WNT signaling pathway.

Wang J, Gan L, Liu F, Yang Q, Deng Q, Jiang D, Zhang C, Zhang L, Wang X
International journal of biological sciences 2024;20(13):5343-5362

DCAF7 Acts as A Scaffold to Recruit USP10 for G3BP1 Deubiquitylation and Facilitates Chemoresistance and Metastasis in Nasopharyngeal Carcinoma.

Li QJ, Fang XL, Li YQ, Lin JY, Huang CL, He SW, Huang SY, Li JY, Gong S, Liu N, Ma J, Zhao Y, Tang LL
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(36):e2403262

The Long Non-Coding RNA NR3C2-8:1 Promotes p53-Mediated Apoptosis through the miR-129-5p/USP10 Axis in Amyotrophic Lateral Sclerosis.

Pang D, Yu Y, Zhao B, Huang J, Cui Y, Li T, Li C, Shang H
Molecular neurobiology 2024 Oct;61(10):7466-7480

FOXQ1, deubiquitinated by USP10, alleviates sepsis-induced acute kidney injury by targeting the CREB5/NF-κB signaling axis.

Zhao Q, Zhang R, Wang Y, Li T, Xue J, Chen Z
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167331

CaMKII Exacerbates Doxorubicin-Induced Cardiotoxicity by Promoting Ubiquitination Through USP10 Inhibition.

Yang Y, Wang Z, Wang N, Yang J, Yang L
Cancer medicine 2024 Nov;13(21):e70286

Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity.

Yang Z, Johnson BA, Meliopoulos VA, Ju X, Zhang P, Hughes MP, Wu J, Koreski KP, Clary JE, Chang TC, Wu G, Hixon J, Duffner J, Wong K, Lemieux R, Lokugamage KG, Alvarado RE, Crocquet-Valdes PA, Walker DH, Plante KS, Plante JA, Weaver SC, Kim HJ, Meyers R, Schultz-Cherry S, Ding Q, Menachery VD, Taylor JP
Cell reports 2024 Mar 26;43(3):113965

The divergent effects of G3BP orthologs on human stress granule assembly imply a centric role for the core protein interaction network.

Yao Z, Liu Y, Chen Q, Chen X, Zhu Z, Song S, Ma X, Yang P
Cell reports 2024 Aug 27;43(8):114617

Hypoxia-induced long non-coding RNA LINC00460 promotes p53 mediated proliferation and metastasis of pancreatic cancer by regulating the miR-4689/UBE2V1 axis and sequestering USP10.

Zhang R, Wang X, Ying X, Huang Y, Zhai S, Shi M, Tang X, Liu J, Shi Y, Li F, Wang W, Deng X
International journal of medical sciences 2023;20(10):1339-1357

Glycolytic Pfkp acts as a Lin41 protein kinase to promote endodermal differentiation of embryonic stem cells.

Cao L, Wang R, Liu G, Zhang Y, Thorne RF, Zhang XD, Li J, Xia Y, Guo L, Shao F, Gu H, Wu M
EMBO reports 2023 Mar 6;24(3):e55683

Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication.

Yang Z, Johnson BA, Meliopoulos VA, Ju X, Zhang P, Hughes MP, Wu J, Koreski KP, Chang TC, Wu G, Hixon J, Duffner J, Wong K, Lemieux R, Lokugamage KG, Alvardo RE, Crocquet-Valdes PA, Walker DH, Plante KS, Plante JA, Weaver SC, Kim HJ, Meyers R, Schultz-Cherry S, Ding Q, Menachery VD, Taylor JP
bioRxiv : the preprint server for biology 2023 Jun 30;

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

Cao YF, Xie L, Tong BB, Chu MY, Shi WQ, Li X, He JZ, Wang SH, Wu ZY, Deng DX, Zheng YQ, Li ZM, Xu XE, Liao LD, Cheng YW, Li LY, Xu LY, Li EM
Cell death and differentiation 2023 Feb;30(2):527-543

Inhibition of Pard3 promotes breast cancer metastasis via the USP28 mediated deubiquitination of Snail1.

Liu Z, Yu Y, Zhou S, Zhang X, Zhou Z
Heliyon 2023 Dec;9(12):e22599

USP10 promotes intrahepatic cholangiocarcinoma cell survival and stemness via SNAI1 deubiquitination.

Zhu W, Ye B, Yang S, Li Y
Journal of molecular histology 2023 Dec;54(6):703-714

USP10 promotes the progression of triple-negative breast cancer by enhancing the stability of TCF4 protein.

Yang JR, Lu YB, Su HX, Xiao Y, Pan Q, Su F, Zhang XB, Zhu KL, Guan QL, Ling XL
Biochemical pharmacology 2023 Dec;218:115864

Limonin stabilises sirtuin 6 (SIRT6) by activating ubiquitin specific peptidase 10 (USP10) in cardiac hypertrophy.

Liu LB, Huang SH, Qiu HL, Cen XF, Guo YY, Li D, Ma YL, Xu M, Tang QZ
British journal of pharmacology 2022 Sep;179(18):4516-4533

High-fidelity reconstitution of stress granules and nucleoli in mammalian cellular lysate.

Freibaum BD, Messing J, Yang P, Kim HJ, Taylor JP
The Journal of cell biology 2021 Mar 1;220(3)

Isoquercitrin protects HUVECs against high glucose‑induced apoptosis through regulating p53 proteasomal degradation.

Liu L, Huang S, Xu M, Gong Y, Li D, Wan C, Wu H, Tang Q
International journal of molecular medicine 2021 Jul;48(1)

Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia.

Lei H, Xu HZ, Shan HZ, Liu M, Lu Y, Fang ZX, Jin J, Jing B, Xiao XH, Gao SM, Gao FH, Xia L, Yang L, Liu LG, Wang WW, Liu CX, Tong Y, Wu YZ, Zheng JK, Chen GQ, Zhou L, Wu YL
Nature communications 2021 Jan 4;12(1):51

Translational Repression of G3BP in Cancer and Germ Cells Suppresses Stress Granules and Enhances Stress Tolerance.

Lee AK, Klein J, Fon Tacer K, Lord T, Oatley MJ, Oatley JM, Porter SN, Pruett-Miller SM, Tikhonova EB, Karamyshev AL, Wang YD, Yang P, Korff A, Kim HJ, Taylor JP, Potts PR
Molecular cell 2020 Aug 20;79(4):645-659.e9

G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules.

Yang P, Mathieu C, Kolaitis RM, Zhang P, Messing J, Yurtsever U, Yang Z, Wu J, Li Y, Pan Q, Yu J, Martin EW, Mittag T, Kim HJ, Taylor JP
Cell 2020 Apr 16;181(2):325-345.e28

Methods for the characterization of stress granules in virus infected cells.

Panas MD, Kedersha N, McInerney GM
Methods (San Diego, Calif.) 2015 Nov 15;90:57-64

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 19374-1-AP(USP10 antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of Hela cells, using USP10 antibody 19374-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line